<p><strong>As demand for GLP-1 receptor agonists like semaglutide continues to rise, analytical laboratories must ensure accurate impurity profiling, regulatory compliance, and long-term method robustness. A new Thermo Fisher Scientific application note presents a powerful stability-indicating HPLC-UV method for semaglutide analysis using the Thermo Scientific </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743"><strong>Vanquish Flex UHPLC system</strong></a><strong> and Thermo Scientific </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1981"><strong>Hypersil GOLD Peptide column</strong></a><strong>.</strong></p><h3><strong>Built for peptide impurity challenges</strong></h3><p>Peptide-related impurities are notoriously difficult to separate due to their structural similarity to the parent compound. To address this, semaglutide samples were subjected to thermal and oxidative stress conditions, generating controlled degradation levels to fully challenge the method.</p><p>The result? A robust analytical workflow capable of resolving closely eluting impurities with confidence.</p><h3><strong>Optimized for maximum resolution</strong></h3><p>Careful optimization of column temperature and gradient conditions significantly improved separation. Increasing the column temperature to 55 °C enhanced resolution between semaglutide and critical impurities, demonstrating the importance of precise thermal control.</p><p>Gradient refinement further improved selectivity while maintaining strong sensitivity which is critical for reliable impurity detection in peptide therapeutics.</p><h3><strong>Superior performance with TFA</strong></h3><p>The study also compared mobile phase additives. While formic acid (FA) is common in LC-MS workflows, trifluoroacetic acid (TFA) delivered sharper peaks and improved chromatographic resolution for HPLC-UV analysis. Peak width at 50% height decreased from 0.83 min with FA to 0.32 min with TFA, dramatically enhancing sensitivity.</p><h3><strong>Proven reproducibility for routine QC</strong></h3><p>Method robustness was confirmed across three different column lots, with %RSD values ≤1.3% for all critical performance parameters.</p><p>This level of consistency supports reliable transfer into quality control and regulated laboratory environments.</p><h3><strong>Advance your semaglutide analysis</strong></h3><p>Whether you are developing generic GLP-1 formulations, supporting regulatory submissions, or optimizing peptide impurity methods, this application note provides practical, data-driven guidance.</p><p>Download the application note, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_004312_pb_glp_1_semaglutide_vanquish_flex_stability_an004312_na_en_10c32c66a3.pdf"><strong>Stability-indicating HPLC-UV method development for GLP-1 receptor analogue semaglutide</strong></a> to explore the full method details, chromatographic data, and reproducibility results.</p><blockquote><ul><li>Stay up to date on the latest GLP-1 analytical technologies and applications. <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/global/forms/industrial/biopharmaceutical-resources-promotions-information-request.html"><strong>Sign up to receive updates</strong></a><strong> </strong>directly in your inbox.</li><li>Explore additional GLP-1 workflows, applications, and solutions on our dedicated <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/pharma-biopharma/biopharma-analytical-solutions.html#industry-insights"><strong>GLP-1 resource hub</strong></a>.</li><li><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#StabilityIndicatingMethod #GLP1 #UHPLC #Semaglutide</li></ul></blockquote>

Stability-Indicating HPLC-UV Method for Semaglutide Impurity Analysis

<p><strong>In-source fragmentation can complicate LC-MS/MS data interpretation because ions may fragment before they reach the collision cell. Instead of obtaining a clean spectrum generated from an isolated precursor ion, the analyst may encounter a mixture containing the protonated molecule, adduct ions, and fragments produced directly in the ion source.</strong></p><p>NIST26 provides tools for recognizing these spectra and searching them against MS/MS libraries. The workflow described by James Little of Mass Spec Interpretation Services shows how chromatogram search results, filtered and unfiltered scores, and the NIST Library Search window can be combined to identify compounds even when the molecular ion is weak or absent.</p><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/in_source_fragmentation_32d33b2c54.pdf"><strong>Download PDF handout here</strong></a></p></blockquote><h4><strong>What is in-source fragmentation?</strong></h4><p>In-source fragmentation occurs when analyte ions fragment within the ion source before conventional tandem mass spectrometry takes place. A typical in-source spectrum therefore contains a mixture of precursor and fragment ions.</p><p>For example, the protonated molecule [M+H]⁺ may remain visible while several fragment ions are simultaneously present. This is fundamentally different from a conventional MS/MS experiment, where a particular precursor is isolated and subsequently fragmented to produce a comparatively clean product-ion spectrum.</p><p>Terms used for these ions include:</p><ul><li>In-source fragment ions</li><li>Source-induced fragments</li><li>In-source fragmentation products</li><li>Source fragmentation ions</li><li>In-source CID products</li></ul><p>The presentation recommends <strong>“in-source fragment ions”</strong> as the clearest and most explicit terminology.</p><h4><strong>Why in-source fragmentation matters for library searching</strong></h4><p>When a reference standard is infused during the generation of NIST library data, MS2 spectra can be acquired not only for molecular-ion adducts but also for fragment ions observed at high resolution.</p><p>This becomes particularly important for compounds whose intact protonated molecule is weak or essentially absent. In such cases, searching exclusively for [M+H]⁺ could prevent a useful library match even though abundant and characteristic fragment ions are available.</p><p>The spectrum illustrated on page 3 of the presentation demonstrates this concept: the same spectrum contains fragment ions at <i>m/z</i> 311 and 333 together with [M+H]⁺ at <i>m/z</i> 377, [M+Na]⁺ at <i>m/z</i> 399, and [M+K]⁺ at <i>m/z</i> 415.</p><h4><strong>Cholesterol: when the protonated molecule is not enough</strong></h4><p>Cholesterol provides a useful example. In positive-ion electrospray, essentially no significant intensity is observed for the [M+H]⁺ ion of cholesterol. Instead, loss of water produces an abundant dehydrated ion.</p><p>Consequently, a major cholesterol MS/MS spectrum in the NIST library is based on <strong>[M+H−H₂O]⁺ at </strong><i><strong>m/z</strong></i><strong> 369.3506</strong> rather than the intact [M+H]⁺ precursor.</p><p>This illustrates an important principle: a useful MS/MS library spectrum does not necessarily have to originate from the intact protonated molecule. Stable and abundant ions generated through predictable in-source fragmentation can also provide valuable information for compound identification.</p><h4><strong>How NIST26 handles small neutral losses</strong></h4><p>For relatively small losses, NIST26 can associate the resulting ion with the correct molecular structure directly in the Chromatogram window.</p><p>This applies to losses such as:</p><ul><li>H₂O</li><li>NH₃</li><li>Other small neutral molecules</li><li>Adduct formation such as [M+Na]⁺</li></ul><p>For cholesterol, for example, a chromatogram search result for [M+H−H₂O]⁺ can therefore still be displayed together with the correct cholesterol structure.</p><p>The presentation provides oxosorbicillinol as another example. Its chromatogram result is associated with the precursor type [M+H−H₂O]⁺ while retaining the identity and structure of oxosorbicillinol.</p><h4><strong>What happens with larger fragment losses?</strong></h4><p>The situation becomes more complicated when fragmentation involves a larger mass loss.</p><p>For large fragment losses, the correct parent structure is <strong>not displayed directly for the corresponding entry in the Chromatogram results list</strong>. Structures are shown there primarily for conventional molecular/adduct ions such as M+H and M+Na and for the small neutral losses discussed above.</p><p>To investigate larger in-source fragments and obtain proposed structures, the spectrum therefore needs to be transferred to the <strong>NIST Library Search window</strong>.</p><h4><strong>Using Score and Score (Unfiltered) to find candidates</strong></h4><p>A useful strategy for recognizing possible in-source fragmentation spectra is to compare the standard <strong>Score</strong> with <strong>Score (Unfiltered)</strong>.</p><p>The presentation recommends adding <strong>Score (Unfiltered)</strong> as a displayed property in the lower Chromatogram window and using a reasonably high value, such as <strong>&gt;800</strong>, in the filter settings. Results can then be sorted by Score (Unfiltered), placing the highest-scoring candidates at the top.</p><p>The analyst should pay particular attention to entries where:</p><p><strong>Score is much lower than Score (Unfiltered).</strong></p><p>Such a large discrepancy can indicate a potentially useful in-source fragmentation spectrum that deserves further investigation.</p><p>The example shown in the presentation is particularly striking:</p><ul><li><strong>Score: 22</strong></li><li><strong>Score (Unfiltered): 928</strong></li></ul><p>Despite the extremely low conventional Score, the very high unfiltered score indicates that the spectrum contains potentially valuable information that can be explored through a dedicated library search.</p><h4><strong>Finding in-source candidates in the chromatogram</strong></h4><p>NIST26 also provides a visual way to recognize potential candidates.</p><p>Possible in-source spectra are indicated by <strong>blue dots in the Chromatogram TIC plot</strong>. Selecting one of these candidates with the mouse changes the marker from blue to <strong>green</strong>, indicating the currently active spectrum linked to the corresponding entry in the results list.</p><p>This makes it possible to move visually through the chromatogram while simultaneously inspecting candidate spectra and their associated scores. The TIC example on pages 7–8 shows how these potential in-source spectra are distributed across the chromatographic run.</p><h4><strong>How to send an in-source spectrum to Library Search</strong></h4><p>Once a promising candidate has been identified, the workflow is straightforward:</p><ol><li>Identify a potential in-source spectrum in the Chromatogram window.</li><li>Check its <strong>Score</strong> and <strong>Score (Unfiltered)</strong> values.</li><li>Select the candidate in the chromatogram.</li><li>Right-click the corresponding entry.</li><li>Select <strong>Library Search</strong>.</li><li>Examine the resulting candidates in the NIST Library Search window.</li></ol><p>Sending the spectrum to Library Search is especially important when larger fragment losses are involved because plausible structures cannot be obtained directly from the Chromatogram results list in these cases.</p><h4><strong>Interpreting the Library Search results</strong></h4><p>Once the in-source spectrum has been transferred to Library Search, several potential identities may be returned with high scores.</p><p>The example on page 9 demonstrates this clearly. Searching an in-source spectrum produces several high-scoring candidate spectra, with the leading result reaching a score of <strong>928</strong>. Multiple library spectra for related candidate compounds may appear because different precursor types, collision energies, or fragmentation pathways can produce compatible spectral patterns.</p><p>The purpose of the search is therefore not simply to accept the first result automatically. Instead, the resulting candidate list provides structures and identities that can be evaluated in the context of the experimental data.</p><h4><strong>Check the Library Search settings</strong></h4><p>Correct search settings are important when working with in-source spectra.</p><p>The presentation illustrates several settings that should be checked before interpreting the results. The search is configured for <strong>Identity</strong> and <strong>MS/MS</strong>, with the precursor ion <i>m/z</i> taken from the spectrum. The illustrated high-resolution library search tolerances are <strong>20 ppm for precursor ions</strong> and <strong>40 ppm for product ions</strong>.</p><p>Another important point is the <strong>MS/MS Hit List Filter</strong>. In the workflow shown in the presentation, <strong>Enable Filtering (Tandem Only)</strong> is switched off.</p><p>Analysts should therefore verify the Library Search options rather than relying on default settings, as inappropriate filtering could remove potentially useful matches from consideration.</p><h4><strong>Practical workflow at a glance</strong></h4><p>For routine investigation of potential in-source fragmentation in NIST26, the presentation suggests the following approach:</p><ol><li>Review the Chromatogram TIC for possible in-source spectra.</li><li>Add <strong>Score (Unfiltered)</strong> to the displayed result properties.</li><li>Apply a relatively high Score (Unfiltered) threshold, with <strong>&gt;800</strong> suggested as a reasonable starting point.</li><li>Sort results by Score (Unfiltered), highest first.</li><li>Look for unusually large differences between <strong>Score</strong> and <strong>Score (Unfiltered)</strong>.</li><li>Select promising candidates marked in the TIC.</li><li>Send spectra involving substantial fragment losses to <strong>NIST Library Search</strong>.</li><li>Verify the MS/MS search and filtering settings.</li><li>Examine the high-scoring library candidates and proposed structures.</li></ol><p>This workflow provides a practical way to extract identification information from spectra that could otherwise appear problematic because the dominant ion is an in-source fragment rather than the expected molecular-ion adduct.</p><h4><strong>Conclusion</strong></h4><p>In-source fragmentation does not necessarily make an LC-MS spectrum unusable. In some cases, particularly for compounds such as cholesterol, a fragment generated before conventional MS/MS can actually be the dominant and analytically useful ion.</p><p>NIST26 addresses this challenge by combining chromatogram-level searching with high-resolution MS/MS library data. Small neutral losses and common adducts can be associated directly with the parent structure, while more substantial fragmentation can be investigated by transferring the spectrum to the Library Search window. Comparing <strong>Score</strong> with <strong>Score (Unfiltered)</strong> provides an additional practical way to recognize promising in-source candidates.</p><p>By understanding these relationships and using the appropriate search settings, analysts can obtain meaningful structural candidates from spectra that might otherwise be overlooked during LC-MS/MS data interpretation.</p>

In-Source Fragmentation Searches in NIST26 Chromatogram Window

<h3><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/"><strong>ISC 2026</strong></a></h3><p><strong>The </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/314"><strong>International Symposium on Chromatography (ISC)</strong></a><strong> represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.</strong></p><h4><strong>35th International Symposium on Chromatography</strong></h4><p>📆<strong>6. - 10. September 2026</strong></p><p>📍<strong>Prague, Czech Republic</strong></p><h3><strong>REGISTRATION</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal"><strong>Register HERE for the ISC 2026</strong></a></p><p><strong>Late Registration until 25 August 2026</strong></p></blockquote><h3><strong>VENDOR SEMINARS</strong></h3><p>Discover the vendor seminars taking place during ISC 2026 in Prague, where leading analytical technology companies will present the latest developments in chromatography, mass spectrometry, and biopharmaceutical analysis. The programme covers stationary phase selectivity, UHPLC and ion chromatography innovations, superficially porous particle columns, virtual GC-MS method modelling, and advanced LC-MS workflows for emerging therapeutics.</p><h4><strong>Lunch seminar Avantor</strong></h4><h5><strong>Stationary Phase Selectivity: A Powerful Tool for Challenging Separations</strong></h5><ul><li>Monday, 7 September 2026&nbsp;</li><li>13:00-14:00</li><li><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://form.jotform.com/262112522534345"><strong>REGISTER HERE</strong></a></li></ul><p>Stationary phase chemistry is one of the most influential variables in chromatographic method development, providing a powerful means of controlling selectivity and achieving successful separations. While the wide range of commercially available stationary phase chemistries provides extensive opportunities to optimise selectivity, navigating these choices can be challenging, often leading to suboptimal column selection and missed opportunities to improve separation performance or speed of analysis.</p><p>This seminar will explore why stationary phase selectivity is one of the most powerful tools available to chromatographers for method development. Approaches for characterizing selectivity, including the Tanaka and Neue methodologies, will be discussed as practical tools for understanding and differentiating column chemistries. These concepts will then be used to demonstrate how stationary phase design can be rationalized and how a deeper understanding of selectivity can guide more effective column selection.</p><p>Application examples will highlight the impact of stationary phase chemistry across a range of analytes, including small molecules and peptides. The seminar will also examine how rational stationary phase selection can be incorporated into streamlined workflows for reversed-phase LC, HILIC and SFC method development.</p><p>Attendees will gain a deeper understanding of how strategic column selection can enhance resolution, reduce method development time, and enhance overall method performance. The concepts presented will provide a practical framework for scientists seeking a more structured, efficient, and knowledge-driven approach to method development.</p><blockquote><p><strong>Dr Matt James</strong></p><p>Matt James is a Senior Research Scientist at Avantor Sciences. Matt gained his PhD at University of Bristol and over the last 15 years, he has worked within the Technical Support, Applications and R&amp;D teams within Hichrom, now part of Avantor. Recent focuses have been HPLC/UHPLC method transfer and translation, the use of solid core phases, development of next generation LC stationary phases and the development of LC methods for key applications, such as the analysis of nitrosamines and PFAS by LC-MS/MS.</p></blockquote><h4><strong>Lunch seminar Shimadzu</strong></h4><h5><strong>Three New Reasons to Rethink Your Workflow</strong></h5><ul><li><strong>Dr. Gesa Schad</strong>, Shimadzu Europa GmbH</li><li><strong>Dr. Waldemar Weber</strong>, Shimadzu Europa GmbH</li><li>Monday, 7 September 2026&nbsp;</li><li>13:00-14:00</li><li><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.shimadzu.eu/forms/vendor-seminar-registartion_isc2026.html"><strong>REGISTER HERE</strong></a></li></ul><p>Join us for an engaging seminar introducing three new analytical solutions designed to help laboratories work smarter, respond faster, improve robustness, and achieve greater confidence in their results. As analytical demands continue to grow, laboratories need technologies that not only deliver strong performance, but also enhance efficiency, flexibility, and ease of operation. This seminar will highlight how the latest innovations can streamline workflows, support complex applications, and create new opportunities for productivity across the laboratory.</p><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=nexera+IC"><strong>Nexera IC</strong></a><strong> – new compact ion chromatograph&nbsp;</strong></h5><ul><li>This new ion chromatography solution is designed to deliver reliable, high-sensitivity analysis for a anions and cations. With a focus on stability, ease of operation, and workflow efficiency, it helps laboratories achieve consistent results while supporting applications in environmental, food, chemical, and pharmaceutical testing.</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=x4"><strong>Nexera X4</strong></a><strong> – No more compromise in UHPLC analysis</strong></h5><ul><li>This next-generation UHPLC platform is designed for laboratories that demand both ultra-high performance and robust operation, without compromise. Combining improved usability with dependable, consistent results, it helps optimize throughput, improve data quality, and simplify daily workflows across both routine and advanced analyses.</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-TQ+RX"><strong>GCMS-TQ RX Series</strong></a><strong> – Enhanced Sensitivity and Reliability in GC-MS/MS Analysis&nbsp;</strong></h5><ul><li>Our new advanced triple quadrupole GC-MS/MS systems are engineered to provide highly sensitive, selective, and dependable analysis for complex samples. Designed to support challenging applications such as trace-level detection and regulatory testing, they enable laboratories to strengthen analytical confidence, improve reproducibility, and manage demanding workflows more effectively.</li></ul><p>Join us to explore the latest innovations and gain valuable insights into our technologies. Register today to secure your place.</p><h4><strong>Lunch seminar Advanced Materials Technology</strong></h4><h5><strong>Advantages of Superficially Porous Particle Columns for HPLC and LC-MS</strong></h5><ul><li><strong>Stephanie Schuster, Joshua McBee, Conner McHale, Peter Pellegrinelli</strong> (Advanced Materials Technology, 3521 Silverside Rd., Wilmington, DE 19810)</li><li>Tuesday, 8 September 2026&nbsp;</li><li>13:00-14:00</li><li><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://halocolumns.com/isc-2026-vendor-lunch-seminar/"><strong>REGISTER HERE</strong></a></li></ul><p><br>Superficially porous particle (SPP) columns have existed in one form or another since the late 1960s. However, the benefits of the particle with the solid silica core surrounded by the porous silica shell were not realized for small molecules until 2006 when the first sub-3-µm superficially porous particle columns were introduced. This particle technology enabled efficiencies similar to sub-2-µm fully porous particles (FPPs) without the need for ultra-high pressure capable instrumentation. As a result of the high efficiencies and lower back pressure, the columns may be run at faster flow rates to enable high throughput separations. Additionally, the SPP columns are rugged and offer long column lifetimes. This presentation will highlight comparisons between SPP columns and FPP columns for separations of pharmaceuticals, pesticides, and oligonucleotides.</p><h4><strong>Lunch seminar Restek</strong></h4><h5><strong>Virtual Chromatographic Modelling Software For Optimising Separation Of Isobaric Compounds in GC-MS Methods</strong></h5><ul><li><strong>Sebastian Prisacariu, Anna Pulte</strong></li><li>Tuesday, 8 September 2026&nbsp;</li><li>13:00-14:00</li><li><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://form.jotform.com/262112099571355"><strong>REGISTER HERE</strong></a></li></ul><p>There is a constant balance for high-throughput laboratories between method run times for large panel analyses and resolution of analytes across these panels to allow sufficient data quality. Developing such methods is often time consuming and expensive for laboratories, as dedicated resources are required to test methods iteratively. Chromatographic modelling tools are becoming increasingly popular for method setup and refinement in high-throughput laboratories looking to minimise instrument and analyst downtime. These tools traditionally offer column phase and method condition suggestions based on the separation of a list of analytes, which can then be modified to improve specific separations as necessary.</p><p>When developing gas chromatography (GC) methods, shortening cycle time often comes at the cost of compounds co-eluting, with the expectation that a mass selective detector, such as a mass spectrometer (MS) will allow resolution through ion-selective quantitation. An issue arises when the method attempts to analyse isobaric compounds, which cannot be distinguished by MS, and as a result labs must rely upon physical separation via column phase chemistry.</p><p>As GC-MS techniques continue to be adopted by laboratories, there is a need for more tools that consider mass data for analytes when optimising large panel separations. The virtual chromatographic modelling tool used in this study is built with mass spectrum data for compounds included in libraries. When operating in “MS mode”, the software identifies isobaric compounds and prioritises their separation when making recommendations regarding column phase and method conditions. For those using non-mass selective detection methods, the tool is easily toggled to “FID mode” for users interested in resolving all compounds, regardless of specific mass, allowing for flexibility in instrumentation. Results help labs save time and resources in method development and refinement by considering the instrumentation involved in the model.</p><h4><strong>Lunch seminar Thermo Fisher Scientific</strong></h4><h5><strong>ASOs, ADCs, and Other Therapeutics: Advanced Characterization with Novel Reversed-Phase Columns and Integrated LC–MS Platform</strong></h5><ul><li>Tuesday, 8 September 2026&nbsp;</li><li>13:00-14:00</li><li><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://forms.cloud.microsoft/pages/responsepage.aspx?id=LXJ9toqqd0ehaevremo7Zz9X1b58h7ZKmlE1n_EPKh5URFJOMFFMVlZWOEc2NUQzWUlTTVY2UEhSTy4u&amp;route=shorturl"><strong>REGISTER HERE</strong></a></li></ul><p>Biotherapeutics are becoming increasingly structurally diverse, placing greater demands on analytical platforms that can support efficient development and regulatory readiness. Reversed-phase chromatography (RPC) remains a widely adopted and adaptable technique, supporting applications that range from oligonucleotide analysis to detailed protein characterization and post-translational modification assessment.</p><p>This seminar explores the integration of a macroporous, monodisperse reversed-phase column with a next-generation bioinert LC system for the analysis of two emerging classes of biotherapeutics. Antisense oligonucleotides were examined under optimized chromatographic conditions, using a design-of-experiments strategy to evaluate how ion-pairing reagents influence both LC separation and downstream MS performance. The platform was further applied to antibody–drug conjugates, combining RPC with Orbitrap mass spectrometry to support multi-level characterization. Intact, sub-unit, and bottom-up analyses enabled drug-to-antibody ratio determination alongside detailed PTM profiling — including glycosylation, oxidation, and deamidation — under native and stress conditions. Collectively, these studies demonstrate a streamlined and adaptable workflow for comprehensive biotherapeutic characterization.</p><blockquote><p><strong>Sara Carillo, Ph.D. &nbsp;</strong>(Bioanalytical Research Lead, Characterization and Comparability Laboratory National Institute for Bioprocessing Research and Training (NIBRT), Dublin, Ireland)</p><p>Sara Carillo completed her Ph.D. in chemical sciences in 2013 at the University of Naples Federico II, where she focused on the structural characterization of polysaccharides and glycoconjugates from Gram-negative bacteria using NMR and mass spectrometry techniques. In 2015, she joined the CCL group at NIBRT, led by Prof. Jonathan Bones. She began her postdoctoral research investigating the effects of extractables and leachables from single-use bioreactors on both the CHO cell N-glycome and the monoclonal antibodies they produce. She currently serves as Bioanalytical Research Lead at NIBRT, where her work centers on developing new mass spectrometry–based analytical approaches to enable deeper and more accessible understanding of biomanufacturing processes and the structural complexity of biopharmaceuticals.</p><p><strong>Sukhdev Bangar</strong> (Senior Product Marketing Manager, Thermo Fisher Scientific, Hemel Hempstead, UK)</p><p>Sukhdev graduated from De Montfort University (UK) with a BSc. in Pharmaceutical Sciences. After which he worked in the Pharmaceutical industry at GSK &amp; Astra Zeneca performing LC &amp; LC-MS analyses. From 2005 till 2023 Sukhdev worked various roles at Waters Corporation; LC-MS applications, Pharma LC-MS Demo group leader and HPLC Product manager. In his current role at Thermo Fisher Scientific he is responsible for marketing activities for the Vanquish analytical LC’s product portfolio. In this role, he represents the voice of the customer helping shape the future of Vanquish LC systems.&nbsp;</p></blockquote>

Vendor Seminars at ISC 2026

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Thermo Fisher Scientific

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer

Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows.

<h4><strong>Superior performance in your routine quantitative analyses</strong></h4><p><strong>Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows. &nbsp;With solutions for today’s needs and technologies to overcome tomorrow’s challenges, explore what the adaptable, flexible, and proven Xevo TQ-XS Tandem Quadrupole Mass Spectrometer coupled with ACQUITY UPLC can afford your laboratory’s productivity and capabilities. &nbsp;</strong></p><div><div><div><div><ul><li><strong>Expanding your efficiencies</strong>: Maximize your laboratory’s potential in high sensitivity quantitative analysis by extending your capabilities, confidently and productively</li><li><strong>Performance that’s proven</strong>: Trust the proven Xevo TQ-XS to meet the analytical demands of your challenging applications , injection after injection</li><li><strong>Digesting your data</strong>: Reduce the burden in data handling with flexible and adaptable software solutions to meet your application and quality system needs</li><li><strong>Supporting your success</strong>: Have confidence that you will exceed your analytical requirements using Waters end to end solutions with flexible service and application focused training and support</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Quantitative analysis where <strong>high sensitivity instrument performance</strong> is required (e.g.,&nbsp;to reach <strong>low level concentrations (ppt)</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: The Xevo TQ-XS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg 245w," sizes="100vw" width="1024" height="545"></p><div><div><h3><strong>Expand your analytical capabilities with enhanced sensitivity</strong></h3><p>Delivering the next step in reliable sensitivity, the <strong>Xevo TQ-XS</strong> enables your laboratory to expand your analytical capacity and productivity. Whether seeking more sensitivity to detect your analytes routinely, looking to extend your scope of analytes with increased confidence or revise your workflow to reduce time and costs, explore what <strong>Xevo TQ-XS</strong>, coupled with <strong>ACQUITY UPLC</strong> and <strong>ACQUITY Premier Systems</strong> can offer your lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Vancomycin: Xevo TQ-XS versus Xevo TQ-S. On average, the analyte area counts on Xevo TQ-XS were >10x higher than area counts on Xevo TQ-S for Vancomycin." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg 245w," sizes="100vw" width="1024" height="295"></p></div></div><div><div><h3><strong>Proven performance you can trust for your challenging analyses</strong></h3><p>Whether looking to streamline your methods or advance your laboratory’s performance, explore how <strong>Xevo TQ-XS</strong>, coupled with <strong>LC (UPLC), GC (APGC) or SFC (UPC2)</strong> can benefit your challenging applications. Trust the proven <strong>Xevo TQ-XS</strong> to meet your <strong>analytical demands</strong>, injection after injection.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Representative liraglutide LLOQ (0.5 ng/mL) chromatogram, extracted from plasma, demonstrating sensitivity and selectivity with Xevo TQ-XS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg 245w," sizes="100vw" width="1024" height="536"></p></div></div><div><div><h3><strong>Software solutions to overcome a common bottleneck</strong></h3><p>While quantitation of targeted analytes can be a routine experiment, the volume of data acquired and generated for processing, review and management can be significant. <strong>Waters</strong>’ informatics platforms offer extensive toolsets to support efficient and compliant <strong>data handling</strong> to support your <strong>21 CFR 11 and ISO 17025</strong> environments.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: With the Xevo TQ-XS System, you’ll get robust results you can trust with the most demanding sample matrices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg 234w," sizes="100vw" width="1024" height="683"></p></div></div><div><div><h3><strong>Accelerating your success with award winning service</strong></h3><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with Waters comprehensive analytical solutions with expert training (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services.html"><strong>APS</strong></a>) and flexible and cost-effective solutions to advance your business with system service <strong>(</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services/flexchoice-instrument-service-coverage.html"><strong>FlexCHOICE</strong></a>), trade-ins and technological upgrades (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/FlexUP-Technology-Renewal-Program-%7C-Upgrade-Lab-Instruments/nav.htm?cid=135071972"><strong>FlexUP</strong></a>).</p></div></div></div></div></div></div>

Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry

From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.

<h3><strong>Defining Compact Performance</strong></h3><ul><li><strong>Robust Sensitivity Beyond Expectations</strong></li></ul><p><strong>From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.</strong></p><h4><strong>Reliable performance</strong></h4><p>Achieve your objectives in full with operational performance you can rely on. A Xevo TQ-S micro study analyzing mycotoxins in wheat flour (a complex matrix that can contaminate LC/MS instrumentation) showed consistent performance over 5 days of continuous use with 1000 injections and only 5-9% relative standard deviation (RSD) for peak areas.</p><h4><strong>Maximizing uptime</strong></h4><p>Get the most from your instrument and avoid time-consuming repair visits. Customers using the Xevo TQ-S micro will on average not need an unplanned service visit during the warranty period and for 3 years after.<strong>*</strong>&nbsp;</p><p><strong>*</strong>Source Waters internal service data on unplanned service visits for Xevo TQ-S micro issues that occur globally. Note that warranty period used is 1 year and planned visits for regular scheduled Performance Maintenance are recommended to ensure trouble-free operation</p><h4><strong>Achieve more with less</strong></h4><ul data-spread="false"><li>The Xevo TQ-S micro is 2-3X narrower than other instruments in its class, reducing laboratory space overhead costs.</li><li>Use of the Xevo TQ-S micro provides up to 34% lower electricity power consumption and associated heat production than other instruments in its class.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: With benchspace at a premium, choose an instrument designed to maximize performance per square inch." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg 245w," sizes="100vw" width="1024" height="300"></p><h4><strong>Flexibility to meet your analytical needs&nbsp;</strong></h4><p>With the most commonly used atmospheric pressure ionization source of ESI as standard, simply change chromatographic inlet or ionization source to extend your analytical capacity and meet changing demands.</p><h3><strong>Reliable Performance</strong></h3><h4><strong>Keeping Variability to a Minimum</strong></h4><p>Be confident that you will have reliable data over multi-day studies. Two experiments using the Xevo TQ-S micro provide evidence for the longer-term stability of this instrument. By monitoring peak areas whilst running continuous injections, you can see that the Xevo TQ-S micro won’t let you down.</p><p><strong>Experiment 1</strong> – 4 mycotoxins in wheat flour showed consistent performance over 5 days of continuous use with 1,000 injections and only 5-9% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 1 showing data for mycotoxins in wheat flour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg 245w," sizes="100vw" width="1221" height="647"></p><p><strong>Experiment 2</strong> – Acetaminophen in protein precipitated plasma also showed consistent performance over 6 ½ days of continuous use with 2,400 injections and only 4% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 2 - Acetominophen in protein precipitated plasma." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg 245w," sizes="100vw" width="1220" height="649"></p><p><strong>Less than 1%</strong> of Waters tandem quadrupole mass spectrometers require a detector replacement on an annual basis.<strong>*</strong></p><p><strong>*</strong>Source: Waters internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022.</p><h3><strong>Improving Efficiency</strong></h3><h4><strong>Lower Operational Costs and Improved Sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it. Many of our customers are actively working to address environmental sustainability while balancing the need to continually reduce operational costs. The Xevo TQ-S micro consumes less electricity than other instruments in its class and therefore produces less heat – lessening the need for air conditioning and lowering costs.</p><p><strong>Table 1:</strong> Instrument / Power Consumption / Heat Output</p><ul><li><strong>Waters Xevo TQ-S micro</strong> / 1250 W / 4,263 Btu/h</li><li><strong>Competitor B</strong> / 1452 W / 4,950 Btu/h</li><li><strong>Competitor A</strong> / 1600 W / 5,456 Btu/h</li><li><strong>Competitor C</strong> / 1960 W / 6,500 Btu/h</li></ul><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/account/sign-in.html"><strong>Xevo TQ-S micro Site Preparation Guide</strong></a><br>Note that power stated for scroll pump configuration. Option for rotary pump configuration is available</p><p>Power and heat outputs for mid tier TQ products, conversion factor 1W = 3.41 Btu/h</p></blockquote><h3><strong>Ultimate Productivity</strong></h3><h4><strong>Achieve More with Flexible Software Solutions</strong></h4><p>The Xevo TQ-S micro is available on both the waters_connect™ and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements.</p><ul data-spread="false"><li><strong>waters_connect™:</strong> Our modern, app-based software platform delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time.</li><li><strong>MassLynx™: </strong>A well-established software package delivering market-leading versatility and flexibility for all application areas.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Flexibility</strong></h3><h4><strong>Choose the Optimal Separation and Ionization Technique for Your Application</strong></h4><p>Waters' market-leading separation technologies include the ACQUITY™ UPLC™ family of LC systems and APGC™. Application flexibility is further enhanced by the range of quickly interchangeable ion source options made possible by universal ion source architecture.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: UPLC/MRM data on Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg 245w," sizes="100vw" width="1024" height="384"></p><h3><strong>Optimal Support</strong></h3><h4><strong>Ensure Your Success with World-Renowned Services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ-S micro, you can:</strong></p><h4><strong>Get up and running quickly&nbsp;</strong></h4><p>Get onsite training and consultation to integrate the Xevo TQ-S micro into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet your lab’s unique requirements</strong></h4><p>Protect your high-performance instrument investment with comprehensive &nbsp;portfolio of service plans such as Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitate compliance</strong></h4><p>Simplify the process of qualification, validation, and recordkeeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce total cost of ownership</strong></h4><p>FlexCAPITAL™<strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage your existing technology</strong></h4><p>With the FlexUP™ technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ-S micro – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>**</strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer

Quantitate with Absolute Power: up to 15× higher sensitivity, 6× longer uptime, and 50% less energy use. The Xevo TQ Absolute XR delivers eXtreme Robustness in a compact design.

<h4><strong>Quantitate with Absolute Power and eXtreme Robustness</strong></h4><p><strong>Gain absolute confidence to make powerful decisions and reach lower limits of quantitation, maintaining optimum sensitivity for longer, with the Xevo TQ Absolute XR instrument.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg" alt="Waters: Xevo TQ Absolute XR Triple Quadrupole MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg 245w," sizes="100vw" width="1603" height="900"></p><p>Engineered for maximum productivity in a compact, sustainable design, the Waters Xevo TQ Absolute XR instrument features the new <strong>StepWave XR ion guide</strong> for enhanced resilience against contamination, even with high-throughput, complex sample matrices. That means more uptime, fewer interventions, and lab performance you can trust, all while aligning with your environmental, social, and governance (ESG) goals.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg" alt="Waters: StepWave XR ion guide" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg 245w," sizes="100vw" width="936" height="388"></p><h4><strong>Overview</strong></h4><ul><li><strong>Absolute confidence: </strong>Experience up to six times more robustness<sup>1</sup> with the new StepWave XR ion guide, designed for superior resilience to contamination. The Xevo TQ Absolute XR Mass Spectrometer ensures consistent, reliable performance, even under the most challenging analytical conditions.</li><li><strong>Absolute performance: </strong>Push quantitation limits further and meet stringent regulatory requirements with up to 15x greater sensitivity<sup>2</sup> for difficult-to-ionize negative mode compounds, setting a new benchmark in high-performance quantitation.</li><li><strong>Absolute efficiency: </strong>Reduce your laboratory’s environmental impact and operational costs with a mass spectrometer that consumes up to 50% less electricity and gas while generating 50% less heat than other high-performance TQ instruments.</li><li><strong>Absolute productivity: </strong>Streamline data analysis with waters_connect software, featuring Exception Focused Review (XFR) functionality to accelerate workflows, cutting data review time by up to 50% for more efficient, accurate results.</li><li><strong>Absolute versatility:</strong> Choose from our differentiated range of source options to find the technology most suited to your applications including DESI XS, APGC, and UniSpray.</li></ul><p><i><strong><sup>1</sup></strong>In a well-controlled experiment, performance was maintained for up to six times the duration on the Xevo TQ Absolute XR compared to the Xevo TQ Absolute; more than 12,000 samples of pesticides in fish feed matrix were analyzed</i></p><p><i><strong><sup>2</sup></strong>Compared to previous generation high performance tandem mass spectrometer, the Xevo TQ-XS.</i></p><ul><li><strong>Recommended Use: </strong>Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.</li></ul><h5><strong>Ensure Absolute confidence with eXtreme Robustness</strong></h5><p>The Xevo TQ Absolute XR Mass Spectrometer analyzes up to six times more samples before service maintenance is required. Get the answer right first time and reduce unplanned downtime! This is one example of multiresidue pesticide analysis in a complex matrix (fish feed), for more examples please visit the brochure.</p><h5><strong>Accelerated Multiresidue Pesticides study</strong></h5><p>Fish feed, an example of a complex, challenging matrix, was tested using QuEChERS extraction without cleanup and without a divert-to-waste step. The Xevo TQ Absolute instrument demonstrated robust performance, operating effectively for approximately 1,500–2,000 injections (~3 months of continuous use1) before any signs of quadrupole charging appeared. The Xevo TQ Absolute XR mass spectrometer further extends this robustness, maintaining stable performance beyond 12,000 injections. Both instruments successfully handled over 400 MRMs in under 6 minutes, with no need for instrument venting for cleaning during the study.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg" alt="Waters: The Xevo TQ Absolute mass spectrometer began to show signs of quadrupole charging after approximately 1,500–2,000 injections of fish feed matrix (represented here by fluazinam; equivalent to ~3 months of use*). In contrast, the Xevo TQ Absolute XR system maintained system performance well beyond 12,000 injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg 234w," sizes="100vw" width="1280" height="853"></p><h5><strong>Achieve Absolute performance with improved sensitivity</strong></h5><p>To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg" alt="Waters: The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg 245w," sizes="100vw" width="1280" height="676"></p><h5><strong>Realize Absolute efficiency and lower operational costs</strong></h5><p>Many businesses are trying to actively address environmental sustainability while also reducing operational costs – and the Xevo TQ Absolute XR instrument helps make that possible.</p><p>With lower electricity consumption, gas consumption, and BTU/hr output, it lessens the demand for air conditioning and drives down energy costs. The minimized LC-MS/MS footprint of the Xevo TQ Absolute XR Mass Spectrometer delivers more analytical power per square foot, enabling lab managers to maximize space and drive greater operational efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg" alt="Waters: The Xevo TQ Absolute XR instrument offers strong performance with less energy consumption in a compact form factor compared to today’s average high-end and high-end MS/MS systems, per data from published vendor site installation guides." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg 245w," sizes="100vw" width="1280" height="622"></p><h5><strong>Achieve Absolute productivity with flexible software options</strong></h5><p>Unlock the full potential of the instrument when paired with our next-generation solution software. From automated data processing to the time-saving Exception Focused Review (XFR) feature, you’ll streamline data review time by up to 50% and spend more time advancing your science.</p><p>Built on a secure, traceable platform, waters_connect for Quantitation is built to accelerate your LC-MS/MS workflows. giving you the absolute confidence to scale, adapt, and lead in any environment.</p><p>For labs that need proven versatility across applications, the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635"><strong>Waters MassLynx Software</strong></a> continues to deliver time-tested flexibility and control.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg" alt="Waters: The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute XR provides absolute productivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg 234w," sizes="100vw" width="1024" height="682"></p><h5><strong>Accelerating your success with award-winning service</strong></h5><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with the Waters comprehensive analytical solutions with expert training (<strong>APS</strong>) and flexible and cost-effective solutions to advance your business with system service (<strong>FlexCHOICE</strong>), trade-ins and technological upgrades (<strong>FlexUP</strong>).</p><h5><strong>Cover more applications from our range of complementary technologies</strong></h5><p>Choose from our comprehensive range of ionization technologies providing differentiated application coverage to get the most from your analyses.</p><ul><li><strong>UniSpray</strong> - Absolute potential unlocked. Enable your lab to improve process efficiency through potential gains in sensitivity, precision and reduced matrix effects, relative to the equivalent electrospray ionization source option.3</li><li><strong>APGC </strong>- The next generation of GC is already here with Atmospheric Pressure Gas Chromatography offering labs absolute power - a powerful alternative to electron ionization technology, enabling low limits of detection, confident compound identification, and confirmation.</li><li><strong>DESI XS</strong> - With a combination of mass spectrometry imaging (MSI) and tandem quadrupole mass spectrometry, a remarkable technique emerges to perform sensitive, fast, and quantitative MSI directly on sample surfaces.&nbsp;</li></ul>

Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry

From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S cronos provides reliable performance at an attractive price point.

<h3><strong>Transform your Quantitative Capabilities</strong></h3><ul><li><strong>Affordable Reliable Performance</strong></li></ul><p><strong>From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S cronos provides reliable performance at an attractive price point.</strong></p><h4><strong>Reliable Performance</strong></h4><p>Achieve your objectives in full with operational performance you can rely on. A Xevo TQ-S cronos study analyzing mycotoxins in cereal (a complex matrix that can contaminate LC/MS instrumentation) showed consistent performance over 5 days of continuous use with 1,000 injections and only 3-8% relative standard deviation (RSD) for peak areas.</p><h4><strong>Affordable Performance</strong></h4><p>Cover your key applications with a robust and cost-efficient instrument that delivers reliable results. The Xevo TQ-S cronos can be applied to key demanding applications such as the quantification of nitrosamines in drug products and quantification of pesticides in fruits, vegetables, and cereals.</p><h4><strong>Cover a Wider Variety of Compounds in One Analysis</strong></h4><p>Choose the UniSpray source option to include ESI and non-ESI amenable compounds in one injection rather than changing chromatographic inlet or ionization source to extend your analytical capacity and meet changing demands.</p><h4><strong>Achieve More with Less</strong></h4><ul data-spread="false"><li>The Xevo TQ-S cronos is 2-3X narrower than most other instruments in its class, reducing laboratory space overhead costs.</li><li>Use of the Xevo TQ-S cronos provides up to 35% lower electrical power consumption and associated heat production than other instruments in its class.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_03f4497b5f.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry - With benchspace at a premium, choose an instrument designed to maximize performance per square inch..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_03f4497b5f.jpg 245w," sizes="100vw" width="1024" height="281"></p><h3><strong>Reliable Performance</strong></h3><h4><strong>Keeping Variability to a Minimum</strong></h4><p>Be confident that you will have reliable data over multi-day studies. Two experiments using the Xevo TQ-S cronos provide evidence for the longer-term stability of this instrument. By monitoring peak areas whilst running continuous injections, you can see that the Xevo TQ-S cronos won't let you down.</p><p><strong>Experiment 1:</strong> 4 mycotoxins in wheat flour showed consistent performance over 5 days of continuous use with 1,000 injections and only 3-8% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_47b4a3d71b.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Experiment 1 showing data for mycotoxins in wheat flour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_47b4a3d71b.jpg 245w," sizes="100vw" width="1201" height="637"></p><p><strong>Experiment 2:</strong> Sulfadimethoxine in protein-precipitated plasma also showed consistent performance over 3 days of continuous use with 1,780 injections and only 4% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Sulfadimethoxine_in_protein_precipitated_plasma_25675e4fc5.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Experiment 2 - Sulfadimethoxine in protein precipitated plasma." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Sulfadimethoxine_in_protein_precipitated_plasma_25675e4fc5.jpg 245w," sizes="100vw" width="1200" height="636"></p><p><strong>Less than 1%</strong> of Waters tandem quadrupole mass spectrometers require a detector replacement on an annual basis.<strong>*</strong></p><p><strong>*</strong>Source: Waters internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022</p><h3><strong>Improving Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with its customers: to leave the world a better place than we found it. Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. The Xevo TQ-S cronos consumes less electricity than most other instruments in its class and therefore produces less heat – lessening the need for air conditioning and lowering costs.</p><h5><strong>Table 1: Instrument / Power Consumption (W) / Heat Output (Btu/h)</strong></h5><ul><li><strong>Competitor B</strong> / 1,100 / 3,700</li><li><strong>Waters Xevo TQ-S cronos*</strong> / 1,230 / 4,194</li><li><strong>Competitor A</strong> / 1,600 / 5,456</li><li><strong>Competitor C</strong> / 1,960 / 6,500</li></ul><blockquote><p><strong>*</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/account/sign-in.html"><strong>Xevo TQ-S cronos Site Preparation Guide</strong></a></p><p>Power and heat outputs for entry tier TQ products, conversion factor 1W = 3.41 Btu/h</p></blockquote><h3><strong>Ultimate Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ-S cronos is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements.</p><p><strong>waters_connect: </strong>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><p><strong>MassLynx:</strong> Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Flexibility</strong></h3><h4><strong>Choose the Optimal Separation and Ionization Technique for Your Application</strong></h4><p>Waters' market-leading separation technologies include the ACQUITY™ UPLC™ family of LC systems. Application flexibility is further enhanced by the range of quickly interchangeable ion source options made possible by universal ion source architecture.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: UPLC/MRM data on Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg 245w," sizes="100vw" width="1024" height="384"></p><p data-pm-slice="1 1 []"><strong>UniSpray™</strong> A novel ionization technique, exclusive to Waters, with wide compound coverage and potential sensitivity benefits. With applicability over a broad range of analytes and a simplified probe design, you can spend less time changing sources and performing maintenance, and more time analyzing your samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Uni_Spray_9cedf20611.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: UniSpray." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Uni_Spray_9cedf20611.jpg 235w," sizes="100vw" width="1465" height="974"></p><h3><strong>Optimal Support</strong></h3><h4><strong>Ensure Your Success with World-Renowned Services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ-S cronos, you can:</strong></p><h4><strong>Get up and running quickly&nbsp;</strong></h4><p>Get onsite training and consultation to integrate the Xevo TQ-S cronos into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet your lab’s unique requirements</strong></h4><p>Protect your high-performance instrument investment with comprehensive &nbsp;portfolio of service plans such as Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitate compliance</strong></h4><p>Simplify the process of qualification, validation, and recordkeeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce total cost of ownership</strong></h4><p>FlexCAPITAL™<strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage your existing technology</strong></h4><p>With the FlexUP™ technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ-S cronos – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>**</strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.

<h3><strong>Quantitate with Absolute Power</strong></h3><ul><li><strong>Harness Absolute Power for Confident, Fast Decisions</strong></li></ul><p><strong>The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.</strong></p><h4><strong>Absolute&nbsp;Performance</strong></h4><p>Achieve lower limits of quantitation to meet regulatory requirements with up to <strong>15x more sensitivity</strong> for challenging negative ionizing compounds than the previous product.</p><h4><strong>Absolute Efficiency &nbsp;</strong></h4><p>Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses <strong>up to 50% less electricity and gas and produces 50% less heat</strong> than most other high performance TQ mass spectrometry instruments on the market.</p><h4><strong>Absolute&nbsp;Productivity</strong></h4><p>Boost your productivity with flexible software solutions, including waters_connect,™ the modern, intuitive informatics solution that can<strong> save up to 50% of your data review time </strong>while facilitating data integrity.&nbsp;</p><h4><strong>Absolute Confidence</strong></h4><p>Ensure consistent robustness and reproducibility so you can <strong>maintain performance and productivity </strong>over a longer time period.</p><h3><strong>Absolute Performance</strong></h3><h4><strong>Increased sensitivity with lower limits of quantitation</strong></h4><p>One of the largest challenges facing many labs is the need to achieve lower limits of quantitation and meet regulatory requirements, particularly for challenging negative ionizing compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: *Xevo TQ Absolute shows up to 15x better ion response as compared to the Xevo TQ-XS and up to 6x better ion response than another leading high-performance LC-MS/MS instrument." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/thumbnail_Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp 245w," sizes="100vw" width="1024" height="540"></p><p>Ensure you have the confidence in your data to make decisions fast with an instrument that provides Absolute Performance. <strong>Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds</strong> than the previous product, so you can make decisions quickly and efficiently.</p><h3><strong>Absolute Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it.&nbsp;</p><p>Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. During development of the Xevo TQ Absolute, Waters has addressed these challenges by providing an instrument with lower electricity consumption, gas consumption, and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p>The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, enabling laboratory managers to fully optimize their facilities and increase efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute Efficiency." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg 206w," sizes="100vw" width="1050" height="794"></p><p>*Source: <a target="_blank" rel="noopener noreferrer" href="https://sciex.com/content/dam/SCIEX/pdf/customer-docs/site-planning-guide/7500-site-planning-guide-en.pdf">https://sciex.com/</a></p><h3><strong>Absolute Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions&nbsp;</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ Absolute is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements</p><h5><strong>waters_connect</strong></h5><p>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><h5><strong>MassLynx</strong></h5><p>Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Absolute Confidence</strong></h3><h4><strong>Tackle your toughest challenges</strong></h4><p>Analytical laboratories face several challenges that are constantly changing, so it’s important to have Absolute Confidence that your analytical instrumentation can keep pace.&nbsp;</p><p>The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility, so you can maintain performance and productivity over a longer time period.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: New source shield technology featured in the Xevo TQ Absolute Mass Spectrometer minimizes contamination and increases uptime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/thumbnail_Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Better by design</strong></h4><p>Optimal probe positioning guidance ensures you can achieve the best possible performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument. A new source shield maximizes uptime by minimizing contamination of the source from sample matrix or mobile phase salts.</p><h3><strong>Absolute Support</strong></h3><h4><strong>Ensure your success with world-renowned services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute support." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/thumbnail_Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp 234w," sizes="100vw" width="1024" height="682"></p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ Absolute, you can:</strong></p><h4><strong>Get Up And Running Quicly</strong></h4><p>Get the onsite training and consultation you need to integrate the Xevo TQ Absolute into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet Your Lab’s Unique Requirements&nbsp;</strong></h4><p>Protect your high-performance instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitates Compliance</strong></h4><p>Simplify the process of qualification, validation, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce Total Cost Of Ownership</strong></h4><p>FlexCAPITAL<strong>** </strong>is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage Your Existing Technology</strong></h4><p>With the FlexUP technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ Absolute – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>** </strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Products from category Mass detectors focused on LC/QQQ distributed by Waters Corporation (Europe) - page 1

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