When every peptide bond matters, fragmentation is where discovery begins. The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958">Thermo Scientific Orbitrap Excedion Pro mass spectrometer</a> brings EASY-ETD and HCD together on a single, ultra-high-performance Orbitrap platform—delivering clarity across proteomics, biopharma, and structural biology.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg 245w," sizes="100vw" width="1024" height="512"><h3>Two fragmentation technologies, one hybrid advantage</h3><h4>EASY-ETD — gentle by design, powerful by nature</h4>EASY-ETD transfers electrons to peptide/protein ions, breaking the backbone while preserving labile PTMs and fragile linkages, generating c- and z-ions ideal for confident site localization. Especially valuable for: phosphorylation, glycosylation, deamidation, isomer discrimination (Asp/IsoAsp; Leu/IsoLeu), and ADC linker–payload integrity.<h5>Example — isomer discrimination with diagnostic ions</h5>In a UHPLC-HRAM ddMS² peptide-mapping experiment on NISTmAb, EThcD (EASY-ETD + supplemental HCD) produced the ETD-diagnostic c+57 and z–57 ions and unambiguously identified isoAsp in a 23-aa, 3+ deamidated peptide present at 0.18%, with &lt;8 ppm mass error for both signatures (Figure 1). This shows how electron-based fragmentation retains the information needed to resolve subtle isomerization that collision-only methods can miss.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 1: EASY-ETD/EThcD reveals isoAsp with signature ions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg 245w," sizes="100vw" width="1024" height="550">EThcD full-MS² spectrum from a NISTmAb tryptic peptide-mapping run. Zoom-in panels highlight z6–57 and c17+57 confirming isoAsp at 0.18% with &lt;8 ppm error.<h4>HCD — High-Energy Confidence for every workflow</h4>HCD generates rich b- and y-ion spectra for robust sequencing and quantitative reproducibility. With the Excedion Pro’s ultra-high-field Orbitrap (MS² up to 70 Hz) and—on the BioPharma edition—an extended mass range to m/z 12,000, HCD supports full sequence coverage, consistent DIA/DDA quantitation, and confident identification of oxidation, deamidation, and truncation variants. Together, EASY-ETD and HCD provide orthogonal fragmentation—comprehensive coverage and high-confidence confirmation in one analysis.<h3>Why combine EASY-ETD and HCD?</h3><ul><li>PTM localization: EASY-ETD preserves fragile sites; HCD confirms sequence context.</li><li>ADC characterization: EASY-ETD keeps linker–payload intact; HCD supports quant and variant checks.</li><li>Isomer detection: EASY-ETD resolves Asp/IsoAsp; HCD adds complementary evidence.</li><li>Quant proteomics: EASY-ETD maintains structural integrity; HCD delivers reproducible intensity.</li><li>Throughput: Electron-driven fragmentation + fast collision MS² (up to 70 Hz).</li></ul><h3>Applications that push the limits</h3><h4>Biopharma Characterization</h4><ul><li>Map DARs and conjugation sites in ADCs with confidence</li><li>Detect low-level PTMs impacting efficacy</li><li>Combine native intact MS and EThcD mapping for complete characterization</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 2. EThcD maps ADC conjugation without cleaving the payload." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg 245w," sizes="100vw" width="1024" height="372">EThcD MS² spectrum of ADYEK(188-MCC-DM1)HK (light chain, z=3). Colored arrows mark c and z fragments used to localize the conjugation site at K188; complementary y/c ions provide sequence context. Data acquired on the Orbitrap Excedion Pro BioPharma platform.<h4>Advanced proteomics</h4><ul><li>Expand sequence coverage in complex proteomes with complementary ion types</li><li>Support Hybrid-DIA for accurate quantitation with fewer false positives</li><li>Profile labile PTMs that collision-only methods may miss</li></ul><h4>Structural biology &amp; HDX-MS</h4><ul><li>Preserve H/D labeling and delicate interactions</li><li>Enable low-flow DIA-HDX with high sensitivity and throughput</li></ul><h3>Hardware that makes it possible</h3><ul><li>OptaMax Plus Ion Source — enhanced spray stability and ease of use</li><li>Advanced Quadrupole Technology (AQT) — ultra-selective precursor isolation</li><li>Ion-Routing Multipole (IRM) — HCD, ETD, and EThcD in a single module</li><li>Electrodynamic Ion Funnel (EDIF) — optimized transmission for labile compounds</li><li>Ultra-high-field Orbitrap analyzer — high mass accuracy and throughput; BioPharma edition supports m/z 12,000</li></ul><h3>Answering the “How” behind advanced fragmentation</h3><ul><li>How does EASY-ETD improve peptide analysis vs standard ETD? Optimized ion routing with optional supplemental activation (EThcD) yields efficient electron transfer and improved sequence coverage—especially for labile or larger peptides. &nbsp;</li><li>Can HCD and EASY-ETD be used in one workflow? Yes—EThcD provides complementary c/z and b/y information in a single MS² event, ideal for PTM localization and conjugation analysis. &nbsp;</li><li>What’s the benefit for biopharma labs? More insight per sample. EASY-ETD localizes modifications or conjugation sites while HCD supports robust quantitation—accelerating analytical development and QC.</li></ul><h3>From complexity to confidence</h3>The Orbitrap Excedion Pro lets scientists choose the right fragmentation energy for every molecule—uncovering fine-structure detail without sacrificing throughput. From intact ADCs to complex proteomes, EASY-ETD + HCD deliver the most complete view of molecular structure available on a hybrid Orbitrap platform.Learn more about <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958">Orbitrap Excedion Pro Mass Spectrometers</a><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#OrbitrapExcedionPro #Orbitrap #MassSpectrometry</blockquote>

Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation

A quick reminder that an important ISC2026 deadline is just around the corner - now is the time to act! Register and complete your payment on time to secure the best rate. Authors of oral presentations are kindly requested to complete their payment to ensure their contributions are included in the program.<blockquote><ul><li>Early-bird registration &amp; payment deadline: May 15, 2026</li><li>Payment deadline for authors of oral presentations: May 15, 2026</li></ul></blockquote><h3>REGISTRATION</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal">Register NOW and do not miss the deadline</a></blockquote><h4>REGISTRATION FEES in EUR including VAT&nbsp;</h4><h5>Early-Bird Registration (until 15 May 2026)</h5><ul><li>Industry: 850</li><li>Academic, Government: 650</li><li>Student*: 290</li><li>Student* + 3 short courses: 390</li><li>Short Courses**: 190</li><li>Accompanying Persons: 190</li><li>Gala Dinner: 100</li></ul><h5>Late Registration (until 25 August 2026)</h5><ul><li>Industry: 1,000</li><li>Academic, Government: 780</li><li>Student*: 340</li><li>Student* + 3 short courses: -</li><li>Short Courses**: 230</li><li>Accompanying Persons: 190</li><li>Gala Dinner: 100</li></ul><h5>Onsite Registration (from 26 August 2026)</h5><ul><li>Industry: 1,150</li><li>Academic, Government: 890</li><li>Student*: 390</li><li>Student* + 3 short courses: -</li><li>Short Courses**: 270</li><li>Accompanying Persons: 190</li><li>Gala Dinner: 100</li></ul>*The student fee applies only to full-time students. This does not include individuals who are employed and pursuing a PhD or other degree part-time. Participants registering under this category are required to upload a valid proof of full time student status (e.g., confirmation from the university or a student ID) directly in the registration form.**The price covers up to 3 short courses for a single flat rate.All the above fees are in EUR and include a local VAT of 21 %.<h5>FULL REGISTRATION FEES INCLUDE:&nbsp;</h5><ul><li>Access to oral and poster sessions&nbsp;</li><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li><li>Electronic Book of Abstracts&nbsp;</li><li>Prague public transportation pass&nbsp;</li></ul><h5>ACCOMPANYING PERSON FEES INCLUDE:&nbsp;</h5><ul><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li></ul>The accompanying persons do not have access to the scientific programme.&nbsp;<h4>Short Courses - New Addition</h4>Our short course program continues to grow! In addition to the existing courses, we’ve added a new course on LC-MS data analysis using mzmine, offering even more hands-on learning opportunities.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/short-courses/">Explore all available courses on the website.</a></blockquote><h4>Exhibition &amp; Sponsorship Opportunities</h4>The ISC 2026 exhibition is filling up, but a few final spots are still available for companies interested in showcasing their products and connecting with the community.<h4>Stay Updated</h4>The ISC 2026 website is regularly updated with the latest information on the program, speakers, and symposium activities - make sure to check it out.Don’t miss these key deadlines - we’re looking forward to seeing you at ISC 2026 in Prague!Best regards,The ISC 2026 Organizing Committee

ISC 2026 Early-Bird Registration & Payment Deadline

We are pleased to announce the following awards that will be presented at RIVA 2026.<h4>MARCEL GOLAY AWARD</h4>The Marcel Golay award was instituted in honor of Marcel Jules Eduard Golay, the inventor of capillary columns.Dr. Golay, one of the pioneers of gas chromatography, introduced the theory of dispersion in open tubular columns (capillary columns) and demonstrated their efficacy at the second International Symposium on Gas Chromatography in 1958. Dr. Golay joined PerkinElmer in 1962 as a senior scientist, and invented the Golay infrared sensor, which at the time was the most sensitive infrared sensor available.Golay’s invention helped establish PerkinElmer as a major source of infrared technology. He also extended the theory of preparative columns and examined the properties of various chromatography sampling systems. The open tubular gas chromatography column is the most popular analytical gas chromatography column in use today. Dr. Golay worked as was a senior scientist at PerkinElmer up until his death in 1989. The Marcel Golay award is presented to a scientist in recognition of a lifetime of achievement in capillary chromatography.Carlo Bicchi is Full Professor at the Faculty of Pharmacy of the University of Turin since 1990. His research focuses on the development of advanced analytical technologies for the study of biologically active specialized metabolites in plant matrices, including essential oils, terpenoids, phenolic compounds, and alkaloids, as well as on aroma profiling and fingerprinting of major industrial food crops such as coffee, cocoa, hazelnuts, olive oil, and tea. His work encompasses all aspects of sample preparation, advanced chromatographic techniques, and chemometric methods for profiling and fingerprinting. Prof. Bicchi has actively promoted the development of analytical sciences through international collaboration, mentoring, and participation in scientific boards, conferences, and editorial activities.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Carlo_Bicchi_a0672a9dbb.jpg" alt="ISCC &amp; GCxGC Symposium: Carlo Bicchi" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Carlo_Bicchi_a0672a9dbb.jpg 156w," sizes="100vw" width="285" height="285"><h4>GIORGIO NOTA AWARD</h4>The Giorgio Nota Award was instituted in honor of Giorgio Nota, who first introduced open tubular LC.The Giorgio Nota award is presented to a scientist in recognition of a lifetime of achievement in capillary liquid chromatography.The Giorgio Nota Award 2026 is sponsored by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/325">Waters</a>.Fernando Mauro Lanças is a full Professor at the Institute of Chemistry of the University of São Paulo at São Carlos, Brazil, where he &nbsp;founded and currently coordinates the Chromatography Laboratory. His commitment to promoting and disseminating the culture of chromatography in Latin America, as founder of the Latin American Congress of Chromatography (COLACRO), the Brazilian Symposium on Chromatography (SIMCRO), and the International Institute of Chromatography (IIC), has made it possible to build a lasting bridge between Latin America and the rest of the world, fostering scientific collaboration, advancing research excellence, and strengthening the global chromatographic community. His primary research interest is currently focused on the complete miniaturization and automation of sustainable sample preparation – chromatography – mass spectrometry techniques and the practical implementation of the Unified Chromatography concept.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Fernando_Mauro_Lancas_e1e0ff9e6a.jpg" alt="ISCC &amp; GCxGC Symposium: Fernando Mauro Lanças" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Fernando_Mauro_Lancas_e1e0ff9e6a.jpg 156w," sizes="100vw" width="285" height="285"><h4>GC×GC LIFETIME ACHIEVEMENT AWARD</h4>The award honors an experienced GC×GC scientist who has made significant contributions to the field.The Scientific Achievement Award &nbsp;was instituted in 2011 and recognizes GC×GC scientists who have 15 or more years of continuous contributions in the field.The 2026 GC×GC Lifetime Achievement Award is sponsored by SepSolve Analytical, Markes International and LECO.Prof. James Harynuk is currently a Full Professor at the University of Alberta, Canada. His research focuses on developing advanced analytical tools to tackle challenges such as complex samples, faster analysis times, and lower detection limits. He specializes in multidimensional gas-phase separations, including GC×GC, heart-cut GC (GC-GC), and advanced data handling tools. Applications of his work span health research, metabolite profiling, forensic science, petrochemicals, and environmental science.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_James_Harynuk_c40ab9f6cc.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. James Harynuk" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_James_Harynuk_c40ab9f6cc.jpg 156w," sizes="100vw" width="285" height="285">Christopher Reddy is senior scientist at the Department of Marine Chemistry and Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. Reddy received his B.S. degree in chemistry from Rhode Island College and his Ph.D. in chemical oceanography from the Graduate School of Oceanography at the University of Rhode Island. His research focuses on the environmental fate of organic pollutants in the ocean, often using advanced analytical techniques such as GC×GC and compound-specific isotope analysis. Drawing on lessons from past pollution, he works to design safer, more environmentally friendly materials.&nbsp; Robert K. Nelson is an organic geochemist invece di research specialist in the Department of Marine Chemistry &amp; Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. He earned a B.A. in biology from Central Connecticut State University and he later expanded his scientific training through additional coursework in organic chemistry at the University of Massachusetts Dartmouth and in physical chemistry at Northeastern University, strengthening his expertise in chemistry as applied to environmental sciences. With an extensive career in organic geochemistry and environmental analysis, Nelson is widely recognized for his contributions to the study of petroleum hydrocarbons and anthropogenic contaminants in the marine environment.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg" alt="ISCC &amp; GCxGC Symposium: Christopher Reddy, Robert K. Nelson" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg 234w," sizes="100vw" width="768" height="512"><h4>JOHN PHILLIPS AWARD</h4>Comprehensive two-dimensional gas chromatograpy, or GC×GC, was invented by the late Professor John Bruce Phillips of Southern Illinois University at Carbondale and his then graduate student, Dr. Zaiyou Liu. The Phillips Prize will be awarded every other year to individuals who have made outstanding contributions to the field of GC×GC analysis. The Phillips Award first given in 2004 recognizes individuals who have typically worked in the GC×GC field for less than 10 years but have demonstrated good leadership through their scientific peer-reviewed work.The 2026 John Phillips Award sponsored by LECO consists of a cash prize and a scroll with the winner’s name.Dr. Meriem Gaida obtained Ph.D. in Analytical Chemistry from the University of Liège (Belgium) in August 2023, specializing in separation science with expertise in GC×GC-ToFMS. Her research focused on advanced analytical strategies for complex chemical profiling and data interpretation, and she further expanded her expertise as a visiting researcher at the University of Washington (USA). After completing her doctorate, she joined SepSolve Analytical Ltd. (UK) as an Applications Specialist, where she developed and optimized customized GC×GC-ToFMS solutions for industrial and academic clients, providing technical support, method development, and training. In September 2024, she moved to LUZI AG (Switzerland), where she currently serves as Product Safety Science Manager, overseeing regulatory compliance, safety assessments of fragrance ingredients, and product safety documentation in line with European regulations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Dr_Meriem_Gaida_fa7cd655a2.jpg" alt="ISCC &amp; GCxGC Symposium: Dr. Meriem Gaida" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Dr_Meriem_Gaida_fa7cd655a2.jpg 156w," sizes="100vw" width="400" height="400"> Petr Vozka is an Associate Professor of Chemistry and Biochemistry at California State University, Los Angeles, where he directs the Complex Chemical Composition Analysis Laboratory (C3AL). He earned a B.S. in Chemistry and Chemical Technologies, and an M.S. in Chemistry and Technology of Fuels and Environment from the University of Chemistry and Technology, Prague, followed by a Ph.D. from Purdue University focused on analytical chemistry of liquid transportation fuels. His research group develops and applies advanced separation and detection strategies, especially comprehensive two-dimensional gas chromatography (GC×GC) coupled with mass spectrometry, to resolve and quantify highly complex mixtures that challenge conventional methods. Application areas include alternative and sustainable fuels, microplastics and related environmental matrices, and forensic analyses such as chemical imaging of fingerprints.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Petr_Vozka_952f1c6248.jpg" alt="ISCC &amp; GCxGC Symposium: Petr Vozka" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Petr_Vozka_952f1c6248.jpg 186w," sizes="100vw" width="768" height="644"><h4>Fritz Pregl Medal of the Austrian Society of Analytical Chemistry awarded to Prof. Christian Huber</h4>The Fritz Pregl award of the Austrian Society of Analytical Chemistry (ASAC) was established in 1955. Since then, it is awarded at irregular intervals primarily at national and international scientific events and symposia.The medal’s namesake, Friedrich Michael Raimund PREGL, received the Nobel Prize in Chemistry in 1923 for his groundbreaking work in the field of microchemical methods, which are closely linked to microanalytical applications. Fritz Pregl is the doyen of Austrian analysts. In his honor, the ASAC established the Pregl Medal, which is awarded to individuals who have made significant and outstanding contributions in the field of analytical chemistry, particularly organic trace analysis.Prof. Christian Huber is currently professor of chemistry for biosciences at the Paris Lodron University in Salzburg, Austria. After finishing his masters and Ph.D. at the university of Innsbruck he continued as an assistant professor at this university.In 1996 Prof. Huber spent several months researching at Yale university in the group of Prof. Csaba Horvath. A year later he was appointed Associate Professor in Innsbruck. From 2002 he held the position of Professor of Analytical Chemistry at the Department of Chemistry, Division of Instrumental Analysis and Bioanalysis, Saarland University, Saarbrücken, Germany. From there he moved to Salzburg in 2008. Prof. Huber is a worldwide known researcher with a strong focus on separation sciences in particular for the analysis of large bio-molecules. According to Google Scholar his work has been cited more than 13500 times with an h-index of 63. In recognition of his contributions to HPLC and HPLC-MS, Prof. Huber will receive the Pregl Award Medal from the Austrian Society of Analytical Chemistry.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_Christian_Huber_31e539d0d9.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. Christian Huber" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_Christian_Huber_31e539d0d9.jpg 156w," sizes="100vw" width="285" height="285">

Awards at the 44th International Symposium on Capillary Chromatography and 21st GCxGC Symposium

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

ISCC & GC×GC Symposium bring together global experts to discuss advances in capillary and multidimensional chromatography, mass spectrometry, and analytical technologies for complex sample analysis.

International Symposium on Capillary Chromatography (ISCC) and GCxGC Symposium

Mestrelab Mnova MSChrom software

Mnova MSChrom (Formerly MS) provides a common interface for different vendor data and automates all functionality such as data importing and display, integration, background subtraction, display of extracted mass chromatograms, molecule match, enumeration of molecular formulae, etc.

<h3>Process, analyze and report your LC-MS and GC-MS data from your different instruments</h3>
Mnova MSChrom (Formerly MS) provides a common interface for different vendor data and automates all functionality such as data importing and display, integration, background subtraction, display of extracted mass chromatograms, molecule match, enumeration of molecular formulae, etc.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Effortlessly_analyze_and_report_LCMS_and_GCMS_data_from_a_wide_range_of_instruments_b7f5482cde.jpg" alt="Mestrelab Research: Mnova MSChrom - Effortlessly analyze and report LCMS and GCMS data from a wide range of instruments."/>
<blockquote>
<h4><a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwslf">Visit MestreLab Research MSChrom product page to learn more!</a></h4>
</blockquote>
<h3>MSChrom Highlights</h3>
<ul>
<li>Common interface to visualize your data from different vendors.</li>
<li>Automate all functionality such as data importing and display, integration, background subtraction, display of extracted mass chromatograms, molecule match, enumeration of molecular formula, etc.</li>
<li>Verify proposed structures by automatically matching molecular ion and isotope peaks, and potentially the MS/MS fragmentation peaks.</li>
<li>Predict the isotope clusters of a molecular formula with various adducts/losses and compare with observed mass spectrum.</li>
<li>Process and report MS data on your computer, improves the efficiency and save time for more complex problems.</li>
<li>Improve your efficiency by automating and customizing the analysis and reporting in batch mode or in real-time using Mnova scripts.</li>
<li>Make your analytical results searchable using Mnova DB!</li>
<li>Calculate MS peak purity. The Mnova MS peak purity shows the curves associated to the most abundant mass peaks under the selected chromatogram peak.</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Opens_the_power_of_the_technique_to_all_non_expert_users_9ccef334fa.jpg" alt="Mestrelab Research: Mnova MSChrom - Opens the power of the technique to all non-expert users."/>
<h3>Mnova MSChrom Features</h3>
<h4>Background Subtraction</h4>
<ul>
<li>This new feature is designed to facilitate background subtraction in your datasets, offering the capability to apply mass spectra and UV subtraction to lower impurities and noisy common peaks obtained from your analytical system, etc. to achieve more precise data analysis.</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Sample_2_and_blank_1_used_to_apply_MS_Background_Subtraction_and_the_result_3_6a554048a8.jpg" alt="Mestrelab Research: Mnova MSChrom - Sample, 2, and blank, 1, used to apply MS Background Subtraction and the result, 3."/>
<h4>New Enhanced Peak Picking Algorithm and Blind Regions</h4>
<ul>
<li>Now, MSChrom includes a new Enhanced Peak Picking Algorithm providing an alternative to the Classic algorithm used in previous versions of MSChrom. Within Enhanced peak picking algorithm new settings are available to reproduce your best results in terms of detection and integration, including Baseline Correction, smoothing features, and a new functionality based on Saturated levels, where users can set an abundance threshold to identify those overloaded peaks due to detector saturation, and perform corrections on them.
</li>
<li>Introducing the new Blind Regions tool-a highly beneficial addition. This tool enables the selective exclusion of those undesired regions from chromatograms during analytical processes as peak picking or any general data treatment. Blind Regions will remain ignored saving time, resources, providing better reproducible results. It proves especially helpful in cases where challenges arise in specific regions (solvent front in LC, column bleeding in GC, etc.) or, for instance, when opting to discard the limits of the chromatogram.
</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Chromatographic_Peak_Detection_Settings_panel_and_Blind_Regions_table_displayed_after_peak_picking_9f4b2b6def.jpg" alt="Mestrelab Research: Mnova MSChrom - Chromatographic Peak Detection Settings panel and Blind Regions table displayed after peak picking process and applying two blind regions on the chromatogram."/>
<h4>Combine NMR and LC-MS or GC-MS Data in the Same Document</h4>
<ul>
<li>Automatically open analytical data from instruments like Agilent, Bruker, JEOL, Thermo, and Waters, along with data in mzData or mzXML formats (<a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gs6">refer to supported formats here</a>).</li>
<li>Integrate peaks in TIC, MS, and UV/ELSD traces, either automatically or manually.</li>
<li>Choose mass spectra based on TIC peaks, with or without background subtraction, and display them in either centroid or profile mode.</li>
<li>Manually co-add mass spectra, and seamlessly analyze and report NMR and MS data together in the same document</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Combine_NMR_and_LC_MS_or_GC_MS_Data_in_the_Same_Document_a575d33699.jpg" alt="Mestrelab Research: Mnova MSChrom - Combine NMR and LC-MS or GC-MS Data in the Same Document."/>
<h4>Effortlessly Generate EMC/EIC, UV Traces, and UV Spectra</h4>
<ul>
<li>Create Extracted Mass/Ion Chromatograms (EMC/EIC) within a specified mass range or at a particular m/z value.</li>
<li>Generate UV Traces effortlessly by selecting a wavelength from a DAD trace.</li>
<li>Easily extract UV spectra at chosen retention times from a PDA total absorbance chromatogram.</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Effortlessly_Generate_EMC_EIC_UV_Traces_and_UV_Spectra_e80492edfa.jpg" alt="Mestrelab Research: Mnova MSChrom - Effortlessly Generate EMC/EIC, UV Traces, and UV Spectra."/>
<h4>Automatic Molecule Matching for Structure Confirmation</h4>
<ul>
<li>Beyond its extensive NMR structure confirmation tools within the NMR plugin, Mnova MSChrom introduces the molecular match feature, an invaluable resource for verifying structures through LC/GC/MS analysis.</li>
<li>This functionality is exceptionally swift and user-friendly, ensuring accessibility for all users, including those new to the field.</li>
<li>Import chemical structures and let the software automatically confirm matches with your experimental data. Customize match criteria by selecting adducts, losses, mass accuracy, score thresholds, etc.</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Automatic_Molecule_Matching_for_Structure_Confirmation_04d66572d1.jpg" alt="Mestrelab Research: Mnova MSChrom - Automatic Molecule Matching for Structure Confirmation."/>
<h4>Isotope Cluster Prediction for Elemental Composition Verification</h4>
<ul>
<li>The feature enables users to propose one or multiple molecular formulas and anticipate their mass peaks using a predefined list of adducts or losses.</li>
<li>Mnova MSChrom generates a list of molecular ion and isotopic peaks, automatically aligning them with experimental peaks, if present.</li>
<li>Customize the display by choosing the desired prediction, along with the corresponding adduct or loss, for comparison on the spectrum.</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Isotope_Cluster_Prediction_for_Elemental_Composition_Verification_7f75f9d6c3.jpg" alt="Mestrelab Research: Mnova MSChrom - Isotope Cluster Prediction for Elemental Composition Verification."/>
<h3>Mnova MSChrom Market and Users</h3>
<ul>
<li>Teaching MS and Chromatography to chemistry departments</li>
<li>Research in organic, medicinal and environmental chemistry</li>
<li>Quality control in chemical and pharmaceutical companies</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_users_507a260da1.jpg" alt="Mestrelab Research: Mnova MSChrom users."/>
<h3>Frequently Asked Questions</h3>
<h5>How can I know if my data is compatible with Mnova?</h5>
Mnova MS supports most of the different MSChrom data formats. You can check it on the MSChrom supported format table <a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gs6">here</a>. Please let us know if your MSChrom data format is not in the list.
<h5>How much does the MSChrom module cost?</h5>
You can find the cost of this module in our online store. You can also check out for any combo option if you have or you need Mnova NMR. For any questions about pricing you can always contact us directly at sales@mestrelab.com
<h5>I have Mnova NMR and I am wondering if I could add my MS data to my NMR reports.</h5>
Yes. You can open NMR and MS data in the same document, and cut/paste the MSChrom display to the same page of NMR data if needed. Or you can create a display template to automatically format the reports.
<h5>Can I use my MSChrom data for verification purposes?</h5>
Yes. Run Molecule Match in Mnova MSChrom to verify the elemental composition automatically, or run Mnova Verify to verify a proposed structure against your MS data (Mnova Verify needs a separate license).
<h5>Can I use it to process my High Resolution MSChrom data?</h5>
Yes. Both high resolution and low resolution MS data can be used by Mnova MSChrom. Just make sure you set the proper mass tolerance parameters when you do Molecular Match.
<h5>Can I try Mnova MSChrom?</h5>
Yes, you can download a 45-day trial license of any of our products. The Mnova MSChrom module is included within the main Mnova installer. Download Mnova and try it now!
<h3>Case Studies</h3>
<h4>Automated analysis and reporting LC/MS and NMR together for compound registration – A case study</h4>
A pharma company does quality control of their compounds using both NMR and LC/MS before registration, and generates the analysis reports in their own format. Based on their requirement, we developed a Mnova script (R_NMR_MS.qs) that does all of this automatically.
<blockquote>
<a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gs9">read more</a>
</blockquote>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_MS_Chrom_Automated_analysis_and_reporting_LC_MS_and_NMR_together_for_compound_registration_A_case_study_8003aab1ff.jpg" alt="Mestrelab Research: Mnova MSChrom - Automated analysis and reporting LC-MS and NMR together for compound registration – A case study."/>

Mestrelab Mnova Gears – Chrom Best Method software

Chrom Best Method is a vendor agnostic tool that can seamlessly screen and compare several chromatographic methods, then suggest the one that is more likely to yield a pure compound.

<h3>Automated solution for selection of the optimal separation method</h3>
Data processing and comparison between different chromatographic methods can quickly form a bottleneck when large amounts of data is generated, particularly when multiple different instruments are involved.
Chrom Best Method is a vendor-agnostic tool that can seamlessly screen and compare several chromatographic methods, then suggest the one that is more likely to yield a pure compound. Chrom Best Method automates LC-MS data processing, target and impurity identification, method scoring, and report generation, to provide quick, smart, and robust answers, whilst still allowing for full review and overriding of results to accommodate users’ needs.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_Find_the_best_separation_conditions_for_your_compounds_with_Chrom_Best_Method_7d0d3f9805.jpg" alt="Mestrelab Research: Save time and money – find the best separation conditions for your compounds with Chrom Best Method!"/>
<blockquote>
<h3><a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskj">Visit MestreLab Research Mnova Gears – Chrom Best Method product page to learn more!</a></h3>
</blockquote>
<h3>Chrom Best Method Benefits</h3>
<ul>
<li>Effective, vendor-neutral analysis and comparison of your LC-MS data from different instruments in one software package.</li>
<li>Seamless evaluation of several methods for many targets in a single run, which accommodates HT experimentation.</li>
<li>Meaningful method scores based on your criteria, preferences, and operational requirements.</li>
<li>Substantial reduction in the time spent on manual analysis and creation of reports.</li>
<li>Effective result visualization and interpretation, enabling quick and confident decision making.</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_2_8cff8a724b.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Best Method software"/>
<h3>Chrom Best Method Features</h3>
<ul>
<li>Automated data preparation, analysis, and reporting of results</li>
<li>Comprehensive method scoring that generates meaningful results</li>
<li>Powerful target peak assignment options and detection of impurities</li>
<li>Multiple ways to provide target information (using a structure, dataset file name, mapping file, or parameters)</li>
<li>Flexible ion matching and analysis options that fit multiple-use cases</li>
<li>Optimized algorithm for chiral screening</li>
<li>Possibility to screen methods on different targets in a single run</li>
<li>Manual review by exception of scoring and ability to override results</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_ccc0c0e0ad.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Best Method software."/>
<h3>Purification Workflow</h3>
<h4>More Automation</h4>
Looking for an enterprise-level solution for improving your purification and data management procedures? Check the <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskm">Fraction Analysis</a> and <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskq">Quality Control</a> bricks that also run in full automation with Mgears. You have the complete flexibility to combine and adapt these solutions to your standard procedures to reap even more benefits to your organization.
<a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gsh">Contact us</a> for more information.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_4_f25f63daa7.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Best Method software"/>
<h3>Markets</h3>
Academic, Government &amp; Industrial
<h4>Who should be using Chrom Best Method?</h4>
Organic chemists, analysts, QC experts, and researchers using quantitative chromatographic methods for quality control, concentration/purity determination, or monitoring/optimization of reactions in one of the following markets and applications:
<ul>
<li>Pharmaceutical / Drug development industry
</li>
<li>Food &amp; Beverage industries
</li>
<li>Personal care and Cosmetics
</li>
<li>Fine chemical synthesis industries
</li>
<li>Polymer industries
</li>
<li>Academic research laboratories
</li>
<li>Contract Research Organizations (CROs) offering purification services
</li>
<li>Compound purification for subsequent use in studies or commercialization
</li>
<li>Isolation of unknown impurities in finished products, natural products, or in the environment for structural disclosure, study, etc.
</li>
<li>Chiral separation to remove unwanted enantiomers obtained during organic synthesis
</li>
</ul>

Mestrelab Mnova Gears software

This comprehensive software suite, designed for building automation workflows, caters to your analytical data needs, spanning NMR, LC/GC-MS, and more.

<h3>Mnova Gears | Real-Time &amp; Batch processes</h3><h4>Automation Workflows for All Your Analytical Data Processes</h4>Are you tired of the monotony of routine data processing? Mnova Gears (also known as Mgears) is here to free up your time for innovation and more engaging tasks. This comprehensive software suite, designed for building automation workflows, caters to your analytical data needs, spanning NMR, LC/GC-MS, and more. Simply set your analysis samples and SOPs, launch the process, and let Mnova Gears handle the rest. From data retrieval to processing and analysis, Mnova Gears effortlessly applies the methods and formulas you provide, presenting the results in comprehensive reports.Experience the flexibility, seamless integration with your existing architecture, and the customizable nature of Mnova Gears. Like Mnova, it remains vendor-neutral, adapting to your unique requirements. Elevate your analytical data processes—automate with Mnova Gears!<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_Gears_Design_your_data_workflows_and_let_Mgears_do_the_rest_5771003702.jpg" alt="Mestrelab Research: Mnova Gears - Design your data workflows and let Mgears do the rest!"><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwsl4">Visit Mestrelab Research Mnova Gears product page to learn more!</a></h4></blockquote><h4>What’s new in Mnova Gears 2.5?</h4>Mnova Gears 2.5 has been released with Mnova 15 introducing a range of new capabilities:<ul><li>New file copy option that copies the input files to the output folder without the need to open, process, or analyze them.</li><li>Ability to add chromatogram blind regions.</li><li>Improved data selection and auto-detection.</li><li>Capability to manage input data organized in multiple subfolders and generate sorted reports for each subfolder.</li><li>Heat map data visualization.</li><li>And other improvements that you can check in the complete changelog.</li></ul>Upgrade to Mgears 2.5 now to explore these features and to unlock the full potential of data automation.Also be sure you check our newest Mgears brick designed for <a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskt">Affinity Selection Mass Spectrometry</a> analyses.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_Gears_Increase_your_efficiency_using_automated_analysis_workflows_c9d3fb13e6.jpg" alt="Mestrelab Research: Mnova Gears - Increase your efficiency using automated analysis workflows!"><h3>Mnova Gears products and how they relate to one another!</h3><h4><a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwsl4">Mnova Gears</a></h4><ul><li>Automation of multiple sample analysis</li><li>Batch and real time mode to generate documents for analysis</li></ul><h4><a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2020-10-22/25htxg">Mnova MyGears</a></h4><ul><li>Automation of single sample analysis</li><li>Automation workflows on an open Mnova document</li></ul><h4><a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gsd">Mnova Gears Bricks</a></h4><ul><li>Build automation workflows using the following Gears bricks</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_Gears_1_b99a72ab8c.jpg" alt="Mestrelab Research: Mnova Gears products and how they relate to one another."><blockquote><h4>Want to run a 45-day FREE trial?</h4><h4><a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gsh">CONTACT AN EXPERT</a></h4></blockquote><h3>Intuitive 5-Step workflow!</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_Gears_Intuitive_5_Step_workflow_9191e59a96.jpg" alt="Mestrelab Research: Mnova Gears - Intuitive 5-Step workflow."><h4>Mnova Gears Benefits</h4><ul><li>Automate routine processes and workflows, saving valuable specialist time.</li><li>Create and manage end-to-end workflows seamlessly within a single tool.</li><li>Streamline multiple analytical workflows on a common, user-friendly platform.</li><li>Customize workflows by selecting components tailored to specific needs.</li><li>Enjoy flexibility and configurability, allowing seamless integration with existing infrastructure.</li><li>Collaborate with different systems in an unified environment due to vendor independence.</li><li>Leverage the familiarity with the Mnova interface to deploy and adopt automation solutions by your team without an extensive learning curve.</li><li>Benefit from expedited product support and development, consolidating all your automation analyses in one software suite.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_Gears_Mnova_Gears_Benefits_3186347cb7.jpg" alt="Mestrelab Research: Mnova Gears - Mnova Gears Benefits"><h4>Mnova Gears Features</h4><h5>Powerful Automation Capabilities for Comprehensive Data Tasks</h5><ul><li>A user-friendly platform equipped with all essential controls for customizing data processes, covering input data, processing and analysis methods, design, and output generation.</li><li>A wide array of default features and options is available to maximize adaptation to customer needs.</li><li>Acceptance of templates and scripts for further customization; you can even construct your own automation bricks using scripting.</li><li>Details of your customization are stored in a settings file, easily shareable and importable.</li></ul><h5>Automatic Reporting and Archiving</h5><ul><li>Diverse output formats, including CSV, PDF, HTML, JSON, and Mnova formats.</li><li>Seamless adaptation to data organization standards by specifying requirements for correct data archiving (in a folder, database, ELN, etc.).</li><li>Easy workflows to automatically update historic data to new standards, ensuring consistency across years and sites.</li><li>Continuous support and updates: Contact the support team for specific import/export format requests.</li></ul><h5>A User-Friendly Result Viewer with Graphical Dashboards for Rapid and Easy Data Review</h5><ul><li>Effortless exploration of results with the Mgears Results Viewer, featuring graphical dashboards.</li><li>At-a-glance and by-exception reviews for quick and effective data analysis.</li><li>Smooth navigation through sample lists or well plates, facilitating the review of data and analyzed spectra.</li><li>Identification of samples not meeting specifications using graphics and warning flags, saving time on extensive scrutiny.</li><li>Swift recalculations and result updates.</li></ul><h4>Multi-Technique and Multi-Application Analytical Workflows</h4><ul><li>Multiple techniques supported: NMR, LC-MS, GC-MS, Chromatography, etc.</li><li>Mnova Gears has already proven its prowess with a broad range of applications spanning from discovery, R&amp;D, to manufacturing and quality control.</li><li>Available applications include structure verification, purity determination, mixture analysis, chemical reaction optimization, and affinity selection mass spectrometry analysis. Explore the <a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gsd">full list of applications</a> for comprehensive coverage.</li></ul><h3>Markets</h3><h5>Academic, Government &amp; Industrial</h5><h4>PRACTICAL APPLICATIONS</h4><ul><li>Quality Control (NMR, Mass Spectrometry, etc)</li><li>Natural Product Dereplication by NMR</li><li>Reaction Monitoring by NMR</li><li>Quantitative NMR</li><li>Targeted mixtures analysis by NMR</li><li>Multi-technique reporting</li><li>Protein-ligand Interaction</li><li>Product ID confirmation</li><li>Structure verification</li><li>DNA Profiling by LCMS</li><li>Ligand-based drug screenings</li><li>Reaction Optimization (HTE)</li><li>Determination of solubility, lipophilicity</li><li>System Suitability testing (NMR, LCMS)</li><li>Compound separation and purification workflows</li></ul>

Mestrelab Mnova Gears – Fraction Analysis software

The tool will evaluate the number and size of peaks present in each fraction, match and assign your target peak, calculate its purity, then score and report the results automatically.

<h3>Automated evaluation of collected elution fractions for decision making</h3>
To pool or not to pool? This may be a tricky question when more than one fraction has been collected for your sample during preparative chromatography.
Fraction Analysis will help you answer it quickly by automating the analysis of fractions and suggesting the most appropriate action to take. The tool will evaluate the number and size of peaks present in each fraction, match and assign your target peak, calculate its purity, then score and report the results automatically. After Fraction Analysis, you will be able to quickly review the results dashboard and pass the selected fraction to downstream quality control processes.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_Gears_Fraction_Analysis_software_Improve_your_chromatography_outcome_by_taking_informed_decisions_on_pooling_b5ede04d20.jpg" alt="Mestrelab Research: Mnova Gears - Fraction Analysis software: Improve your chromatography outcome by taking informed decisions on pooling, or otherwise, the eluate fractions!"/>
<blockquote>
<h3><a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskm">Visit MestreLab Research Mnova Gears – Fraction Analysis product page to learn more!</a></h3>
</blockquote>
<h3>Fraction Analysis Benefits</h3>
<ul>
<li>Huge time savings on spectral data analysis and preparation of professional-looking reports with the results</li>
<li>Reduce the risk of pooling a pure eluate fraction with a poor-quality one</li>
<li>Bring insight into the results and decide whether to stick to the suggested action or manually override it</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_2_8cff8a724b.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Fraction Analysis software."/>
<h3>Fraction Analysis Features</h3>
<ul>
<li>Automated data ingestion, processing, analysis, and report generation</li>
<li>Powerful scoring based on peak number, size, and target mass purity</li>
<li>Flexible analysis options</li>
<li>Color coded dashboards and tables with analysis results</li>
<li>Automatic, data-driven suggestion for subsequent action (to keep and QC, or dispose of or review the elution fraction)</li>
<li>Possibility to override the automatically generated results</li>
<li>Summary CSV output with results that can be used as input files for the next-stage analysis</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_Gears_Fraction_Analysis_software_1_d59b34f8a9.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears - Fraction Analysis software."/>
<h3>Purification Workflow</h3>
<h4>More Automation</h4>
Looking for an enterprise-level solution for improving your purification and data management procedures? Check the <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskj">Best Method</a> and <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskq">Quality Control</a> bricks that also run in full automation, and learn more about our automated databasing solution with Mgears. You have the complete flexibility to combine and adapt these solutions to your standard procedures to reap even more benefits for your organization.
<a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gsh">Contact us</a> for more information.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_4_f25f63daa7.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Fraction Analysis software."/>
<h3>Markets</h3>
Academic, Government &amp; Industrial
<h4>Who should be using Fraction Analysis?</h4>
Organic chemists, analysts, QC experts, and researchers using quantitative chromatographic methods for quality control, concentration/purity determination, or monitoring/optimization of reactions in one of the following markets and applications:
<ul>
<li>Pharmaceutical/Drug development industry</li>
<li>Food &amp; Beverage industries</li>
<li>Personal care and Cosmetics</li>
<li>Fine chemical synthesis industries</li>
<li>Polymer industries</li>
<li>Academic research laboratories</li>
<li>Contract Research Organizations (CROs) offering purification services</li>
<li>Compound purification for subsequent use in studies or commercialization</li>
<li>Isolation of unknown impurities in finished products, natural products, or in the environment for structural disclosure, study, etc.</li>
<li>Chiral separation to remove unwanted enantiomers obtained during organic synthesis</li>
</ul>

Mestrelab Mnova Gears – Chrom QC software

This automation tool will run end-to-end QC workflows for you and deliver decision-enabling reports with all the results you’ll need.

<h3>Automated workflow for high throughput quality control using LC/GC-MS</h3>
Compound quality control can be challenging and time consuming when manual input for processing or result interpretation is needed. If you are an organic chemist, medicinal chemist, formulation scientist, or a quality specialist and want to analyze your compound libraries to assert compound identity and assess purity, Chrom QC is your best ally. This automation tool will run end-to-end QC workflows for you and deliver decision-enabling reports with all the results you’ll need.
Chrom QC runs on the Gears automation engine, which means that any LC/GC-MS format can be handled independently from the instrument software packages. Data is automatically retrieved from your directories (in batches or real time), matched to the corresponding molecular structures, formulae, masses, etc., and analyzed to confirm compound identity and determine purities. Custom csv, html, mnova, and PDF reports can also be automatically generated, and results can be sent directly to your database! Even better, all of this can be achieved with only minimal setup effort!
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_QC_software_All_your_purity_analyses_in_a_single_software_package_ff88cd29f6.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software: All your purity analyses in a single software package!"/>
<blockquote>
<h3><a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskq">Visit MestreLab Research Mnova Gears – Chrom QC product page to learn more!</a></h3>
</blockquote>
<h3>Chrom QC Benefits</h3>
<ul>
<li>Quality control all your compounds using one software package that supports all the major proprietary LC-MS data formats – make your quality control independent of the devices used!</li>
<li>Streamline your lot and batch release programs by automating data processing, analysis, and report generation</li>
<li>High-quality data in a timely manner to enhance your lab productivity</li>
<li>Effective result visualization with possible manual review</li>
<li>Save your compound results in your Mnova databases on-the-fly</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_2_8cff8a724b.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software."/>
<h3>Chrom QC Features</h3>
<ul>
<li>Support to the majority of <a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gs6">LC/GC-MS data formats</a></li>
<li>Automatic detection and matching of input data files with provided information</li>
<li>Flexible peak identification methods using molecular structures, formulae and masses, or peak size</li>
<li>Possible extraction of multiple traces for purity and concentration calculations</li>
<li>Automated reporting with customization options and use of design templates (html, mnova, PDF, csv)</li>
<li>Color-coded plate view to enable review-by-exception of the results</li>
<li>Manual peak selection tool for result correction</li>
<li>Automatic result archiving and databasing</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_QC_software_d27c9333ee.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software."/>
<h3>Purification Workflow</h3>
<h4>More Automation</h4>
Looking for an enterprise-level solution for improving your purification and data management procedures? Check the <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskj">Best Method</a> and <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskm">Fraction Analysis</a> bricks that also run in full automation, and learn more about our automated databasing solution with Mgears. You have the complete flexibility to combine and adapt these solutions to your standard procedures to reap even more benefits for your organization.
<a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gsh">Contact us</a> for more information.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_4_f25f63daa7.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software."/>
<h3>Markets</h3>
Academic, Government &amp; Industrial
<h4>Who should be using Chrom QC?</h4>
Organic chemists, analysts, QC experts, and researchers using quantitative chromatographic methods for quality control, concentration/purity determination, or monitoring/optimization of reactions in one of the following markets and applications:
<ul>
<li>Pharmaceutical/Drug development industry</li>
<li>Food &amp; Beverage industries</li>
<li>Personal care and Cosmetics</li>
<li>Fine chemical synthesis industries</li>
<li>Polymer industries</li>
<li>Academic research laboratories</li>
<li>Contract Research Organizations (CROs)</li>
<li>Quality control of synthesized or acquired compounds prior to registration</li>
<li>Quality control of compound collections prior to use in biological assays</li>
<li>Quality control of finished compounds prior release to the market (drugs, food additives, preservatives, etc.)</li>
<li>Quality control for formulation optimization and definition of storage recommendations</li>
</ul>

SciY Mnova Gears – Chrom Reaction Optimization software

With this new  Automated Software Solution for Chemical Reaction Optimization from Mnova Gears, determining the ideal reaction conditions becomes an easy, hassle-free, and quick task.

<h3>Automated Software Solution for Chemical Reaction Optimization</h3>With this new Automated Software Solution for Chemical Reaction Optimization from Mnova Gears, determining the ideal reaction conditions becomes an easy, hassle-free, and quick task. Chrom Reaction Optimization allows you to track a defined set of chemicals across multiple parallel reactions to compare their levels and conclude on the best experimental conditions to employ.Set up your workflow from data pick-up to results drop-off, and scale it up as needed. Results are matched to the designed experimental points and are delivered in many formats including graphical visuals to enable quick and informed decision making.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Automate_data_processes_to_quickly_find_the_safest_most_efficient_c5ed26927d.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Automate data processes to quickly find the safest, most efficient, cost-effective synthetic schemes for your reactions."><blockquote><h3><a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwsl1">Visit Mnova Gears – Chrom Reaction Optimization product page to learn more!</a></h3></blockquote><h3>Chrom Reaction Optimization Highlights</h3><ul><li>Seamless handling of large chromatography datasets removing bottleneck related to high throughput experimentation approaches</li><li>Robust and repetitive data management workflows that will replace the tedious manual processing required for each sample</li><li>Huge time saving by enabling review-by-exception strategy</li><li>Control over results quality and easy detection and correction of errors that may occur during processing and analysis</li><li>Quick and confident decision making based on global and graphical reports with the analysis results</li><li>Structured analytical data reporting and archiving to comply with standards</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_features_a3c019c8e9.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software features."><h3>Chrom Reaction Optimization Features</h3><h4>Fully customizable and reusable analysis methods</h4><h5>Reaction optimization input, data processing, analysis, reporting and results archiving is fully customizable to fit your needs.</h5>Reaction optimization runs with the Mnova Gears platform and therefore benefits from the huge flexibility in input configuration which allows you to adapt analysis to your own data organization and formats. Input can come from disk directories or from the instrument in real time acquisition, and can be organized in many different ways. Mgears can be set to recognize and pick up the data for the analysis.<h5>On the other hand, analysis options can be customized:</h5><ul><li>Components to track/ignore</li><li>Compound matching options using structure or retention times</li><li>Analysis thresholds and controls, etc</li></ul>All analysis options can be saved, shared, and re-used in the future which allows huge time savings and robustness in the process.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Fully_customizable_and_reusable_analysis_methods_ad6b3b966c.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Fully customizable and reusable analysis methods."><h4>Flag system for warnings about non-conformances</h4>Analysis criteria can be defined by experts and colored flags configured to get warnings when sample analysis does not fulfill the specified requirements. For instance, a sample can be flagged when no peaks are detected, when component peaks overlap, and/or when RT variation exceeds an acceptable threshold.Detecting these non-conformances is crucial to keep control over results quality. You can review the flagged sample in the Result Viewer to investigate the problem, easily correct peak assignments if needed, and re-analyze samples to update the results.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Flag_system_for_warnings_about_non_conformances_60517716c1.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Flag system for warnings about non-conformances."><h4>Graphical summary of results and automatic global reports</h4>Chrom Reaction Optimization simplifies decision making by generating global and graphical reports with the analysis results. Reports are generated in multiple formats, including a dynamic html format that allows data sorting (increasing or decreasing order) and export to new reports.Quantities of reaction starting materials, products, and other declared compounds are graphically represented in charts making it easier to decide on the best reaction conditions at a glance!<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Graphical_summary_of_results_and_automatic_global_reports_c5976ac1f6.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Graphical summary of results and automatic global reports."><h3>Markets</h3>Academic, Government &amp; Industrial<h4>Who should be using Chrom Reaction Optimization?</h4>This Automated Software Solution for Chemical Reaction Optimization is suitable for all Organic, medicinal, and process chemists, in the following market fields:<ul><li>(bio)Pharmaceutical / Drug development and manufacturing</li><li>Food &amp; Bev industries / Synthesis of additives, flavors, etc.</li><li>Personal care and Cosmetics industry / Synthesis of preservatives, fragrances, emulsifiers, etc.</li><li>Agrochemical industry/ Synthesis of herbicides, insecticides, etc.</li><li>Polymers industry / Synthesis of new polymers</li><li>Other fine chemicals industries</li></ul>

Products from category Software and libraries from SciY/Mestrelab Research - page 2

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