We are pleased to announce that a maintenance release is now available for KnowItAll 2025.Maintenance releases are an important way to introduce improvements and bug fixes between major releases to make sure users get the most out of KnowItAll solutions.Late 2024, we announced the KnowItAll 2025 major release featuring the new LC Expert tool, KnowItAll Data Control, KnowItAll Drug Classification Models, and various advances for spectral analysis workflows. This is the first update available after that release.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Know_It_All_LC_Expert_Streamline_component_identification_with_the_power_of_the_new_Know_It_All_LC_Expert_s_automated_workflow_84a090a7c2.jpg" alt="Wiley: NEW! KnowItAll LC Expert: Streamline component identification with the power of the new KnowItAll LC Expert’s automated workflow." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Know_It_All_LC_Expert_Streamline_component_identification_with_the_power_of_the_new_Know_It_All_LC_Expert_s_automated_workflow_84a090a7c2.jpg 245w," sizes="100vw" width="1735" height="960"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Know_It_All_drug_classification_models_25277cc5e0.jpg" alt="Wiley: NEW! KnowItAll drug classification models." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Know_It_All_drug_classification_models_25277cc5e0.jpg 245w," sizes="100vw" width="603" height="324">We encourage users to ensure they are using the most recent version of the software for best performance.<blockquote>Current users can <a target="_blank" rel="noopener noreferrer" href="https://get.knowitall.com/Download?_gl=1*18h0vjr*_gcl_au*Mjk3ODY0Mzg1LjE3MTMyNzcyMDEuMTkwNDkyNDI4NS4xNzEzMzY3NDc0LjE3MTMzNjc0Nzk.">download the most recent version here</a>.</blockquote><h4>Learn more about KnowItAll 2025:&nbsp;&nbsp;</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/whats-new-in-knowitall-2025/">What's New&nbsp;</a> &nbsp;&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/knowitall-version-history/">Version History</a></li></ul><h4>About KnowItAll</h4>KnowItAll Software offers solutions to analyze and manage multiple types of spectral and chemical data in multiple file and instrument formats. KnowItAll's integrated toolsets eliminate the need for multiple software packages and increase overall lab efficiency and staff proficiency. Combined with Wiley’s comprehensive, high-quality spectral reference libraries, it provides an unparalleled solution for fast, reliable spectral analysis.<h4>About Wiley</h4>Wiley (NYSE: WLY) is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at <a target="_blank" rel="noopener noreferrer" href="https://www.wiley.com/en-ie">Wiley.com</a>.&nbsp;

KnowItAll 2025 Maintenance Release 2025.1 Available

SIELC has developed the first and only HPLC software that is accessible via the cloud - <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1250">HPLC.cloud</a>.<h4>&nbsp;Special Features:</h4><ul><li>Cloud Integration: Real-time data streaming and storage on HPLC.cloud ensure your experiment data is always backed up and accessible.</li><li>Remote Access: Control and monitor your system from anywhere — lab, office, or on the go — using a PC, tablet, or phone.</li><li>Data Security: All your results are stored in a centralized, secure location — so no data is ever lost.</li><li>Sync Capabilities: Chromatograms are synced with HPLC.cloud every second, providing real-time experiment updates.</li></ul><h4>Key Functionality:</h4><ul><li>Real-time Chromatogram Streaming: Watch live data as it’s being collected.</li><li>Sequence Building and Recording: Build, record, and store experiment sequences.</li><li>Method Storage: Save and reuse methods for consistency and efficiency.</li><li>Data Accessibility: Store all your sample and result data securely in the cloud, accessible anytime.</li><li>Remote Control: Start, stop, or modify analyses from any internet-connected device.</li><li>Comprehensive Data Analysis: Calibrate, analyze, and quantify directly within the cloud interface.</li><li>Mobile and PC Access: Use on PC, tablet, or smartphone for maximum flexibility.</li><li>Online Data Search: Easily search and access your data from anywhere.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SIELC_SIELC_Software_HPLC_cloud_1_441d304d5d.jpg" alt="SIELC: SIELC Software – HPLC.cloud" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SIELC_SIELC_Software_HPLC_cloud_1_441d304d5d.jpg 225w," sizes="100vw" width="801" height="554">No software installation. No USBs. No data loss.

How to Use HPLC Cloud - A Complete Guide

News from LabRulezLCMS Library - Week 20, 2025

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Organomation NITRO-GEN+ Nitrogen Generator

The NITRO-GEN+ Nitrogen Generator is designed to satisfy the needs of the LC-MS and sample preparation fields.

The NITRO-GEN+ Nitrogen Generator is designed to satisfy the needs of the LC-MS and sample preparation fields. The NITRO-GEN+ is compatible with all Organomation nitrogen evaporators up to 100 sample positions, along with most LC-MS analyzers on the market. It relies on Pressure Swing Adsorption (PSA) technology to separate nitrogen from the air. The unit uses molecular sieves to remove oxygen, water, and trace hydrocarbons, leaving a stream of high purity nitrogen gas. Nitrogen is produced by utilizing a combination of this Carbon Molecular Sieve technology along with high and low pressure compressors.This unique technology allows the nitrogen to be produced at a low pressure and an ambient temperature, eliminating the need for high pressure cylinders which can be dangerous for the technicians handling them. The low pressure also ensures a longer compressor life, which reduces the time and money spent on regular maintenance. The generator's simple installation and operation combined with its superior reliability makes the NITRO-GEN+ a staple in any laboratory.<h4>Standard features</h4><ul><li>Integrated low noise, oil free compressors</li><li>On-demand supply 24/7</li><li>Proprietary carbon molecular sieve technology</li><li>Complete "plug and play" LC-MS solution</li><li>Two-year complete product warranty or 8,000 hour run-time warranty</li></ul><h4>Compatible features</h4><ul><li>All Organomation evaporators up to 100 sample positions</li><li>Most LC-MS analyzers on the market</li></ul><h4>Specification</h4><h5>Key Features:</h5><ul><li>Flow Rate: Up to 35 L/min</li><li>Nitrogen Purity:<ul><li>Up to 99% at ≤ 25 L/min</li><li>Up to 98% at &gt; 25 L/min</li></ul></li><li>Dewpoint: -58 °F (-50 °C)</li><li>Output Pressure: 0 – 116 PSI (0 – 8 bar)</li><li>Warm-Up Time: 20 minutes</li><li>Technology: Carbon molecular sieve (CMS)</li></ul><h5>Electrical &amp; Safety:</h5><ul><li>Power Supply:<ul><li>110–120 V, 60 Hz</li><li>220–240 V, 50 Hz</li></ul></li><li>Total Wattage: 1800 W</li><li>Protection Rating:<ul><li>Electrical: IP20</li><li>Mechanical Impact: IK08</li></ul></li><li>Noise Level: 55 dBA at 1 meter</li></ul><h5>Dimensions &amp; Weight:</h5><ul><li>Size (W × D × H): 18.9 × 33 × 25 in (48 × 83.8 × 63.5 cm)</li><li>Weight: 198 lbs (90 kg)</li></ul><h5>Connections &amp; Certifications:</h5><ul><li>Outlet Connection: 6 mm OD compression or 1/4"</li><li>Certifications: CE, FCC, MET (UL and CSA compliant)</li></ul><h5>Environmental Specifications:</h5><ul><li>Operating Temperature: 59–95 °F (15–35 °C)</li><li>Relative Humidity:<ul><li>0–80% (non-condensing)</li><li>0–99% (with condensation drain)</li></ul></li><li>Altitude: &lt; 2000 m (800–1150 hPa)</li></ul>Warranty: 2 years or 8,000-hour runtime (whichever comes first)

Organomation NITRO-GEN Nitrogen Generator

The NITRO-GEN generator was developed with Organomation’s nitrogen evaporators in mind to provide nitrogen generation for sample concentration.

The NITRO-GEN generator was developed with Organomation’s nitrogen evaporators in mind to provide nitrogen generation for sample concentration. The generator is lightweight and easy to set up, requiring only a source of compressed air to run. This unit is an ideal choice for labs with an in-house compressed air source.The generator uses a hollow-fiber membrane to convert compressed air to a stream of 95-99% pure nitrogen gas. The hollow-fiber membrane consists of a series of narrow, semipermeable tubes in a porous membrane. As compressed air travels through the fibers, oxygen and water vapor permeate the membrane and are vented off, leaving a steam of high purity nitrogen gas. At up to 99% purity, the resulting nitrogen gas stream can be used in a variety of sample preparation applications.<h4>NITRO-GEN</h4>The NITRO-GEN produces up to 20 L/min of nitrogen gas and is recommended for evaporation of up to 48 sample positions.&nbsp;<h4>Standard features</h4><ul><li>Adjustable outlet pressure regulator, 0-100 psi</li><li>Dual Stage clean air filtration system</li><li>Requires an oil-less compressed air source</li></ul><h4>Advantages</h4><ul><li>Quick Start-Up Time - Nitrogen is produced instantly, no heat up time</li><li>Saves Energy - No electrical power needed</li><li>Engineered Design - Life expectancy is more than 10 years</li><li>Low Maintenance - Serviceable clean air filter</li><li>Compact and Lightweight - Small footprint conserves valuable bench space</li><li>Reduced CO2 Emissions - No heaters, less energy required</li></ul><h4>Specification</h4><h5>Key Features:</h5><ul><li>Flow Rate: Up to 20 L/min</li><li>Technology: Hollow-fiber membrane</li><li>Output Pressure: Adjustable 0 – 100 PSI</li><li>Electrical Requirements: None (no power required)</li><li>Noise Level: &lt; 40 dBA (virtually silent when connected to an instrument)</li></ul><h5>Inlet Air Requirements:</h5><ul><li>Maximum Inlet Pressure: 150 PSI (10.3 bar)</li><li>Particulate Filtration: ≤ 0.01 µm</li><li>Oil Vapor Content: &lt; 0.01 mg/m³ (&lt; 0.01 ppm)</li><li>Relative Humidity: &lt; 100% (non-condensing)</li><li>Air Quality: Clean, contaminant-free air</li></ul><h5>Environmental Conditions:</h5><ul><li>Operating Temperature: 36–122 °F (2–50 °C)</li><li>Ambient Pressure: Atmospheric</li></ul><h5>Dimensions &amp; Weight:</h5><ul><li>Size (W × D × H): 9.5 × 8 × 19.5 in (241 × 203 × 495 mm)</li><li>Weight: 13.25 lbs (6 kg)</li></ul>Warranty: 1 year

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How to Use HPLC Cloud - A Complete Guide

News from LabRulezLCMS Library - Week 20, 2025

KnowItAll 2025 Maintenance Release 2025.1 Available