<p><strong>When every peptide bond matters, fragmentation is where discovery begins. The </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958"><strong>Thermo Scientific Orbitrap Excedion Pro mass spectrometer</strong></a><strong> brings EASY-ETD and HCD together on a single, ultra-high-performance Orbitrap platform—delivering clarity across proteomics, biopharma, and structural biology.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg 245w," sizes="100vw" width="1024" height="512"></p><h3><strong>Two fragmentation technologies, one hybrid advantage</strong></h3><h4><strong>EASY-ETD — gentle by design, powerful by nature</strong></h4><p>EASY-ETD transfers electrons to peptide/protein ions, breaking the backbone while <strong>preserving labile PTMs and fragile linkages</strong>, generating <strong>c- and z-ions</strong> ideal for confident site localization.<br><strong>Especially valuable for:</strong> phosphorylation, glycosylation, deamidation, <strong>isomer discrimination</strong> (Asp/IsoAsp; Leu/IsoLeu), and <strong>ADC linker–payload integrity</strong>.</p><h5><strong>Example — isomer discrimination with diagnostic ions</strong></h5><p>In a UHPLC-HRAM ddMS² peptide-mapping experiment on <strong>NISTmAb</strong>, <strong>EThcD</strong> (EASY-ETD + supplemental HCD) produced the ETD-diagnostic <strong>c+57</strong> and <strong>z–57</strong> ions and <strong>unambiguously identified isoAsp</strong> in a <strong>23-aa, 3+</strong> deamidated peptide present at <strong>0.18%</strong>, with <strong>&lt;8 ppm</strong> mass error for both signatures (<strong>Figure 1</strong>). This shows how electron-based fragmentation retains the information needed to resolve subtle isomerization that collision-only methods can miss.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 1: EASY-ETD/EThcD reveals isoAsp with signature ions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg 245w," sizes="100vw" width="1024" height="550"></p><p>EThcD full-MS² spectrum from a NISTmAb tryptic peptide-mapping run. Zoom-in panels highlight <strong>z6–57</strong> and <strong>c17+57</strong> confirming <strong>isoAsp</strong> at 0.18% with <strong>&lt;8 ppm</strong> error.</p><h4><strong>HCD — High-Energy Confidence for every workflow</strong></h4><p><strong>HCD</strong> generates rich <strong>b- and y-ion</strong> spectra for robust sequencing and quantitative reproducibility. With the Excedion Pro’s <strong>ultra-high-field Orbitrap</strong> (MS² up to <strong>70 Hz</strong>) and—on the <strong>BioPharma edition</strong>—an <strong>extended mass range to m/z 12,000</strong>, HCD supports <strong>full sequence coverage</strong>, consistent <strong>DIA/DDA</strong> quantitation, and confident identification of oxidation, deamidation, and truncation variants. Together, EASY-ETD and HCD provide <strong>orthogonal fragmentation</strong>—comprehensive coverage and high-confidence confirmation in one analysis.</p><h3><strong>Why combine EASY-ETD and HCD?</strong></h3><ul><li><strong>PTM localization:</strong> EASY-ETD preserves fragile sites; HCD confirms sequence context.</li><li><strong>ADC characterization:</strong> EASY-ETD keeps linker–payload intact; HCD supports quant and variant checks.</li><li><strong>Isomer detection:</strong> EASY-ETD resolves Asp/IsoAsp; HCD adds complementary evidence.</li><li><strong>Quant proteomics:</strong> EASY-ETD maintains structural integrity; HCD delivers reproducible intensity.</li><li><strong>Throughput:</strong> Electron-driven fragmentation + fast collision MS² (<strong>up to 70 Hz</strong>).</li></ul><h3><strong>Applications that push the limits</strong></h3><h4><strong>Biopharma Characterization</strong></h4><ul><li>Map <strong>DARs</strong> and conjugation sites in <strong>ADCs</strong> with confidence</li><li>Detect <strong>low-level PTMs</strong> impacting efficacy</li><li>Combine <strong>native intact MS</strong> and <strong>EThcD mapping</strong> for complete characterization</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 2. EThcD maps ADC conjugation without cleaving the payload." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg 245w," sizes="100vw" width="1024" height="372"></p><p>EThcD MS² spectrum of <strong>ADYEK(188-MCC-DM1)HK</strong> (light chain, z=3). Colored arrows mark <strong>c</strong> and <strong>z</strong> fragments used to localize the conjugation site at <strong>K188</strong>; complementary <strong>y/c</strong> ions provide sequence context. Data acquired on the <strong>Orbitrap Excedion Pro BioPharma</strong> platform.</p><h4><strong>Advanced proteomics</strong></h4><ul><li>Expand <strong>sequence coverage</strong> in complex proteomes with complementary ion types</li><li>Support <strong>Hybrid-DIA</strong> for accurate quantitation with fewer false positives</li><li>Profile <strong>labile PTMs</strong> that collision-only methods may miss</li></ul><h4><strong>Structural biology &amp; HDX-MS</strong></h4><ul><li>Preserve <strong>H/D labeling</strong> and delicate interactions</li><li>Enable <strong>low-flow DIA-HDX</strong> with high sensitivity and throughput</li></ul><h3><strong>Hardware that makes it possible</strong></h3><ul><li><strong>OptaMax Plus Ion Source</strong> — enhanced spray stability and ease of use</li><li><strong>Advanced Quadrupole Technology (AQT)</strong> — ultra-selective precursor isolation</li><li><strong>Ion-Routing Multipole (IRM)</strong> — <strong>HCD, ETD, and EThcD</strong> in a single module</li><li><strong>Electrodynamic Ion Funnel (EDIF)</strong> — optimized transmission for labile compounds</li><li><strong>Ultra-high-field Orbitrap analyzer</strong> — high mass accuracy and throughput; <strong>BioPharma edition</strong> supports <strong>m/z 12,000</strong></li></ul><h3><strong>Answering the “How” behind advanced fragmentation</strong></h3><ul><li><strong>How does EASY-ETD improve peptide analysis vs standard ETD?</strong><br>Optimized ion routing with optional supplemental activation (<strong>EThcD</strong>) yields efficient electron transfer and improved sequence coverage—especially for labile or larger peptides.<br>&nbsp;</li><li><strong>Can HCD and EASY-ETD be used in one workflow?</strong><br>Yes—<strong>EThcD</strong> provides complementary <strong>c/z</strong> and <strong>b/y</strong> information in a single MS² event, ideal for PTM localization and conjugation analysis.<br>&nbsp;</li><li><strong>What’s the benefit for biopharma labs?</strong><br><strong>More insight per sample.</strong> EASY-ETD localizes modifications or conjugation sites while HCD supports robust quantitation—accelerating analytical development and QC.</li></ul><h3><strong>From complexity to confidence</strong></h3><p>The <strong>Orbitrap Excedion Pro</strong> lets scientists choose the right fragmentation energy for every molecule—uncovering fine-structure detail without sacrificing throughput. From intact ADCs to complex proteomes, <strong>EASY-ETD + HCD</strong> deliver the most complete view of molecular structure available on a hybrid Orbitrap platform.</p><p>Learn more about <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958"><strong>Orbitrap Excedion Pro Mass Spectrometers</strong></a></p><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#OrbitrapExcedionPro #Orbitrap #MassSpectrometry</p></blockquote>

Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation

<p><strong>A quick reminder that an important ISC2026 deadline is just around the corner - now is the time to act! Register and complete your payment on time to secure the best rate. Authors of oral presentations are kindly requested to complete their payment to ensure their contributions are included in the program.</strong></p><blockquote><ul><li><strong>Early-bird registration &amp; payment deadline:</strong> May 15, 2026</li><li><strong>Payment deadline for authors of oral presentations: </strong>May 15, 2026</li></ul></blockquote><h3><strong>REGISTRATION</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal"><strong>Register NOW and do not miss the deadline</strong></a></p></blockquote><h4><strong>REGISTRATION FEES in EUR including VAT&nbsp;</strong></h4><h5><strong>Early-Bird Registration (until 15 May 2026)</strong></h5><ul><li><strong>Industry: </strong>850</li><li><strong>Academic, Government: </strong>650</li><li><strong>Student*:</strong> 290</li><li><strong>Student* + 3 short courses: </strong>390</li><li><strong>Short Courses**: </strong>190</li><li><strong>Accompanying Persons: </strong>190</li><li><strong>Gala Dinner:</strong> 100</li></ul><h5><strong>Late Registration (until 25 August 2026)</strong></h5><ul><li><strong>Industry: </strong>1,000</li><li><strong>Academic, Government: </strong>780</li><li><strong>Student*:</strong> 340</li><li><strong>Student* + 3 short courses: </strong>-</li><li><strong>Short Courses**: </strong>230</li><li><strong>Accompanying Persons: </strong>190</li><li><strong>Gala Dinner:</strong> 100</li></ul><h5><strong>Onsite Registration (from 26 August 2026)</strong></h5><ul><li><strong>Industry: </strong>1,150</li><li><strong>Academic, Government: </strong>890</li><li><strong>Student*:</strong> 390</li><li><strong>Student* + 3 short courses: </strong>-</li><li><strong>Short Courses**: </strong>270</li><li><strong>Accompanying Persons: </strong>190</li><li><strong>Gala Dinner:</strong> 100</li></ul><p><i><strong>*</strong>The student fee applies only to full-time students. This does not include individuals who are employed and pursuing a PhD or other degree part-time. Participants registering under this category are required to upload a valid proof of full time student status (e.g., confirmation from the university or a student ID) directly in the registration form.</i></p><p><i><strong>**</strong>The price covers up to 3 short courses for a single flat rate.</i></p><p><i>All the above fees are in EUR and include a local VAT of 21 %.</i></p><h5><strong>FULL REGISTRATION FEES INCLUDE:&nbsp;</strong></h5><ul><li>Access to oral and poster sessions&nbsp;</li><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li><li>Electronic Book of Abstracts&nbsp;</li><li>Prague public transportation pass&nbsp;</li></ul><h5><strong>ACCOMPANYING PERSON FEES INCLUDE:&nbsp;</strong></h5><ul><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li></ul><p><i>The accompanying persons do not have access to the scientific programme.&nbsp;</i></p><h4><strong>Short Courses - New Addition</strong></h4><p>Our short course program continues to grow! In addition to the existing courses, we’ve added a new course on <strong>LC-MS data analysis using mzmine</strong>, offering even more hands-on learning opportunities.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/short-courses/"><strong>Explore all available courses on the website.</strong></a></p></blockquote><h4><strong>Exhibition &amp; Sponsorship Opportunities</strong></h4><p>The ISC 2026 exhibition is filling up, but a few final spots are still available for companies interested in showcasing their products and connecting with the community.</p><h4><strong>Stay Updated</strong></h4><p>The ISC 2026 website is regularly updated with the latest information on the program, speakers, and symposium activities - make sure to check it out.</p><p>Don’t miss these key deadlines - we’re looking forward to seeing you at ISC 2026 in Prague!</p><p>Best regards,</p><p>The ISC 2026 Organizing Committee</p>

ISC 2026 Early-Bird Registration & Payment Deadline

<p><strong>We are pleased to announce the following awards that will be presented at RIVA 2026.</strong></p><h4><strong>MARCEL GOLAY AWARD</strong></h4><p>The <strong>Marcel Golay award</strong> was instituted in honor of Marcel Jules Eduard Golay, the inventor of capillary columns.</p><p>Dr. Golay, one of the <strong>pioneers of gas chromatography</strong>, introduced the theory of dispersion in open tubular columns (capillary columns) and demonstrated their efficacy at the second International Symposium on Gas Chromatography in 1958. Dr. Golay joined PerkinElmer in 1962 as a senior scientist, and invented the Golay infrared sensor, which at the time was the most sensitive infrared sensor available.</p><p>Golay’s invention helped establish PerkinElmer as a major source of infrared technology. He also extended the theory of preparative columns and examined the properties of various chromatography sampling systems. The open tubular gas chromatography column is the most popular analytical gas chromatography column in use today. Dr. Golay worked as was a senior scientist at PerkinElmer up until his death in 1989. The Marcel Golay award is presented to a scientist in recognition of a lifetime of achievement in capillary chromatography.</p><p><strong>Carlo Bicchi</strong> is Full Professor at the Faculty of Pharmacy of the University of Turin since 1990. His research focuses on the development of advanced analytical technologies for the study of biologically active specialized metabolites in plant matrices, including essential oils, terpenoids, phenolic compounds, and alkaloids, as well as on aroma profiling and fingerprinting of major industrial food crops such as coffee, cocoa, hazelnuts, olive oil, and tea. His work encompasses all aspects of sample preparation, advanced chromatographic techniques, and chemometric methods for profiling and fingerprinting. Prof. Bicchi has actively promoted the development of analytical sciences through international collaboration, mentoring, and participation in scientific boards, conferences, and editorial activities.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Carlo_Bicchi_a0672a9dbb.jpg" alt="ISCC &amp; GCxGC Symposium: Carlo Bicchi" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Carlo_Bicchi_a0672a9dbb.jpg 156w," sizes="100vw" width="285" height="285"></p><h4><strong>GIORGIO NOTA AWARD</strong></h4><p>The <strong>Giorgio Nota Award</strong> was instituted in honor of Giorgio Nota, who first introduced open tubular LC.</p><p>The Giorgio Nota award is presented to a scientist in recognition of a lifetime of achievement in capillary liquid chromatography.</p><p>The <strong>Giorgio Nota Award 2026 is sponsored by </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/325"><strong>Waters</strong></a>.</p><p><strong>Fernando Mauro Lanças</strong> is a full Professor at the Institute of Chemistry of the University of São Paulo at São Carlos, Brazil, where he &nbsp;founded and currently coordinates the Chromatography Laboratory. His commitment to promoting and disseminating the culture of chromatography in Latin America, as founder of the Latin American Congress of Chromatography (COLACRO), the Brazilian Symposium on Chromatography (SIMCRO), and the International Institute of Chromatography (IIC), has made it possible to build a lasting bridge between Latin America and the rest of the world, fostering scientific collaboration, advancing research excellence, and strengthening the global chromatographic community. His primary research interest is currently focused on the complete miniaturization and automation of sustainable sample preparation – chromatography – mass spectrometry techniques and the practical implementation of the Unified Chromatography concept.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Fernando_Mauro_Lancas_e1e0ff9e6a.jpg" alt="ISCC &amp; GCxGC Symposium: Fernando Mauro Lanças" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Fernando_Mauro_Lancas_e1e0ff9e6a.jpg 156w," sizes="100vw" width="285" height="285"></p><h4><strong>GC×GC LIFETIME ACHIEVEMENT AWARD</strong></h4><p>The award honors an experienced GC×GC scientist who has made significant contributions to the field.</p><p>The Scientific Achievement Award &nbsp;was instituted in 2011 and recognizes GC×GC scientists who have 15 or more years of continuous contributions in the field.</p><p>The <strong>2026 GC×GC Lifetime Achievement Award</strong> is sponsored by <strong>SepSolve Analytical, Markes International and LECO</strong>.</p><p><strong>Prof. James Harynuk</strong> is currently a Full Professor at the University of Alberta, Canada. His research focuses on developing advanced analytical tools to tackle challenges such as complex samples, faster analysis times, and lower detection limits. He specializes in multidimensional gas-phase separations, including GC×GC, heart-cut GC (GC-GC), and advanced data handling tools. Applications of his work span health research, metabolite profiling, forensic science, petrochemicals, and environmental science.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_James_Harynuk_c40ab9f6cc.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. James Harynuk" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_James_Harynuk_c40ab9f6cc.jpg 156w," sizes="100vw" width="285" height="285"></p><p><strong>Christopher Reddy</strong> is senior scientist at the Department of Marine Chemistry and Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. Reddy received his B.S. degree in chemistry from Rhode Island College and his Ph.D. in chemical oceanography from the Graduate School of Oceanography at the University of Rhode Island. His research focuses on the environmental fate of organic pollutants in the ocean, often using advanced analytical techniques such as GC×GC and compound-specific isotope analysis. Drawing on lessons from past pollution, he works to design safer, more environmentally friendly materials.&nbsp;<br><br><strong>Robert K. Nelson</strong> is an organic geochemist invece di research specialist in the Department of Marine Chemistry &amp; Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. He earned a B.A. in biology from Central Connecticut State University and he later expanded his scientific training through additional coursework in organic chemistry at the University of Massachusetts Dartmouth and in physical chemistry at Northeastern University, strengthening his expertise in chemistry as applied to environmental sciences. With an extensive career in organic geochemistry and environmental analysis, Nelson is widely recognized for his contributions to the study of petroleum hydrocarbons and anthropogenic contaminants in the marine environment.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg" alt="ISCC &amp; GCxGC Symposium: Christopher Reddy, Robert K. Nelson" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg 234w," sizes="100vw" width="768" height="512"></p><h4><strong>JOHN PHILLIPS AWARD</strong></h4><p>Comprehensive two-dimensional gas chromatograpy, or GC×GC, was invented by the late <strong>Professor John Bruce Phillips </strong>of Southern Illinois University at Carbondale and his then graduate student, Dr. Zaiyou Liu. The Phillips Prize will be awarded every other year to individuals who have made outstanding contributions to the field of GC×GC analysis. The Phillips Award first given in 2004 recognizes individuals who have typically worked in the GC×GC field for less than 10 years but have demonstrated good leadership through their scientific peer-reviewed work.</p><p>The <strong>2026 John Phillips Award sponsored by LECO</strong> consists of a cash prize and a scroll with the winner’s name.</p><p><strong>Dr. Meriem Gaida </strong>obtained Ph.D. in Analytical Chemistry from the University of Liège (Belgium) in August 2023, specializing in separation science with expertise in GC×GC-ToFMS. Her research focused on advanced analytical strategies for complex chemical profiling and data interpretation, and she further expanded her expertise as a visiting researcher at the University of Washington (USA). After completing her doctorate, she joined SepSolve Analytical Ltd. (UK) as an Applications Specialist, where she developed and optimized customized GC×GC-ToFMS solutions for industrial and academic clients, providing technical support, method development, and training. In September 2024, she moved to LUZI AG (Switzerland), where she currently serves as Product Safety Science Manager, overseeing regulatory compliance, safety assessments of fragrance ingredients, and product safety documentation in line with European regulations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Dr_Meriem_Gaida_fa7cd655a2.jpg" alt="ISCC &amp; GCxGC Symposium: Dr. Meriem Gaida" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Dr_Meriem_Gaida_fa7cd655a2.jpg 156w," sizes="100vw" width="400" height="400"><br><br><strong>Petr Vozka </strong>is an Associate Professor of Chemistry and Biochemistry at California State University, Los Angeles, where he directs the Complex Chemical Composition Analysis Laboratory (C3AL). He earned a B.S. in Chemistry and Chemical Technologies, and an M.S. in Chemistry and Technology of Fuels and Environment from the University of Chemistry and Technology, Prague, followed by a Ph.D. from Purdue University focused on analytical chemistry of liquid transportation fuels. His research group develops and applies advanced separation and detection strategies, especially comprehensive two-dimensional gas chromatography (GC×GC) coupled with mass spectrometry, to resolve and quantify highly complex mixtures that challenge conventional methods. Application areas include alternative and sustainable fuels, microplastics and related environmental matrices, and forensic analyses such as chemical imaging of fingerprints.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Petr_Vozka_952f1c6248.jpg" alt="ISCC &amp; GCxGC Symposium: Petr Vozka" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Petr_Vozka_952f1c6248.jpg 186w," sizes="100vw" width="768" height="644"></p><h4><strong>Fritz Pregl Medal of the Austrian Society of Analytical Chemistry awarded to Prof. Christian Huber</strong></h4><p>The <strong>Fritz Pregl award of the Austrian Society of Analytical Chemistry (ASAC)</strong> was established in 1955. Since then, it is awarded at irregular intervals primarily at national and international scientific events and symposia.</p><p>The medal’s namesake, Friedrich Michael Raimund PREGL, received the Nobel Prize in Chemistry in 1923 for his groundbreaking work in the field of microchemical methods, which are closely linked to microanalytical applications. Fritz Pregl is the doyen of Austrian analysts. In his honor, the ASAC established the Pregl Medal, which is awarded to individuals who have made significant and outstanding contributions in the field of analytical chemistry, particularly organic trace analysis.</p><p><strong>Prof. Christian Huber</strong> is currently professor of chemistry for biosciences at the Paris Lodron University in Salzburg, Austria. After finishing his masters and Ph.D. at the university of Innsbruck he continued as an assistant professor at this university.</p><p>In 1996 Prof. Huber spent several months researching at Yale university in the group of Prof. Csaba Horvath. A year later he was appointed Associate Professor in Innsbruck. From 2002 he held the position of Professor of Analytical Chemistry at the Department of Chemistry, Division of Instrumental Analysis and Bioanalysis, Saarland University, Saarbrücken, Germany. From there he moved to Salzburg in 2008. Prof. Huber is a worldwide known researcher with a strong focus on separation sciences in particular for the analysis of large bio-molecules. According to Google Scholar his work has been cited more than 13500 times with an h-index of 63. In recognition of his contributions to HPLC and HPLC-MS, Prof. Huber will receive the Pregl Award Medal from the Austrian Society of Analytical Chemistry.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_Christian_Huber_31e539d0d9.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. Christian Huber" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_Christian_Huber_31e539d0d9.jpg 156w," sizes="100vw" width="285" height="285"></p>

Awards at the 44th International Symposium on Capillary Chromatography and 21st GCxGC Symposium

Article

Product

Events

Video

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

ISCC & GC×GC Symposium bring together global experts to discuss advances in capillary and multidimensional chromatography, mass spectrometry, and analytical technologies for complex sample analysis.

International Symposium on Capillary Chromatography (ISCC) and GCxGC Symposium

Thermo Scientific mzCloud Mass Spectral Library

mzCloud is a high-resolution, accurate-mass MSⁿ spectral library that helps identify unknown compounds when no reference standards are available, especially in complex studies.

<div colctrl-id="1-1"><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><h3><strong>Confident identification for unknown small molecules</strong></h3></div></div><div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Mass spectral libraries and databases may be required to identify unknown compounds when reference standards are not available. This is particularly true for studies in areas such as metabolomics, forensic toxicology, food &amp; beverage, environmental emerging contaminants or extractables &amp; leachables.</strong></p></div></div></div></div><div><p>In these situations, a mass spectral library, particularly a high-resolution and accurate-mass MS<sup>n</sup> fragmentation library, such as the mzCloud mass spectral library, can provide the information required to confidently identify unknown compounds.</p><h3><strong>Key benefits</strong></h3><h5><strong>Confidence for unknown identification</strong></h5><p>Comprehensive curation of all library content with extensive, fully annotated and searchable fragmentation spectra to provide confidence in your results.</p><h5><strong>Know more unknowns&nbsp;&nbsp;&nbsp;&nbsp;</strong></h5><p>Identify unknowns with automated deconvolution and library searching against extensive fragmentation spectra covering a wide chemical space, including small molecule applications.</p><h5><strong>From spectra to structure&nbsp;&nbsp;</strong></h5><p>With solutions to cover infusion or LC-MS, nominal or high-resolution data, you can be sure that your MS<sup>n</sup> spectra will provide you with actionable results, even when there is no spectral library match.</p><h5><strong>Flexibility for research and routine applications</strong></h5><p>Search for free online at <a target="_blank" rel="noopener noreferrer" href="http://www.mzcloud.org/" aria-label="mzCloud.org - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="http://www.mzcloud.org/$mzcloud.org"><span style="white-space:nowrap;">mzCloud.org</span></a>, or directly access through the Thermo Scientific Compound Discoverer and Mass Frontier software packages. Not online? mzVault provides you with the ability to perform offline spectral library searching.</p><figure class="image"><img style="aspect-ratio:1398/1002;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_ecc79fe9bf.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: mzCloud is easily and freely accessed online. Anyone can search, review, and use its extensive information. Note that the numbers above were correct at time of publication. For the most up to date numbers visit mzCloud.org." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_ecc79fe9bf.jpg 218w," sizes="100vw" width="1398" height="1002"></figure><h3><strong>What is in the mzCloud mass spectral library?</strong></h3><div style="height:auto;" id="whatismzcloud"><div><div><div><div><p>mzCloud is an extensively curated, high-quality mass spectral fragmentation library that contains significant amounts of spectra and metadata for each entry. Each entry also includes exhaustive high-resolution <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html?open=multi-stage-fragmentation#multi-stage-fragmentation">MS/MS and multi-stage MS<sup>n</sup> spectra</a>, which have been acquired at various collision energies and using different fragmentation techniques.</p><p><strong>Each raw mass spectrum</strong> has been filtered to remove noise, recalibrated to ensure absolute mass accuracy, fully annotated and <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html?open=content-curation#content-curation">curated</a> to ensure quality and consistency.</p><p>Finally, the contents of the library are <strong>updated weekly</strong> to provide coverage of a wide chemical space, ensuring relevance to all small-molecule application areas.</p></div><div><figure class="image"><img style="aspect-ratio:740/410;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_2_77a6795676.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: Example of the Mass Frontier software utilizing the contents of mzCloud to identify an unknown compound through a sub-structural search; the experimental fragmentation spectrum (top left) is searched against the mzCloud mass spectral database, with corresponding spectral hits shown in a given spectral tree (top, middle), with supporting spectral information (bottom left) and the identified precursor structure from the matched fragmentation spectra (bottom right), and the library compound structure from which the fragment originated (top right)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_2_77a6795676.jpg 245w," sizes="100vw" width="740" height="410"></figure></div><div><p>Distinguishing among types of databases is important, as the contents and quality of the contents typically differs significantly and may have an impact upon the reliability of the data and the confidence in any results obtained.</p><ul><li><strong>Chemical database</strong>: A collection of chemical information with, at minimum, a name and a formula. It may also include structures, elemental composition, retention time information, and additional biological or chemical metadata.</li><li><strong>Accurate-mass (AM) database</strong>: An AM database contains accurate mass formulas.</li><li><strong>Accurate-mass retention-time (AMRT) database</strong>: An AMRT database contains accurate mass and retention time(s) for specific analytical methods.</li><li><strong>Library</strong>: A library is a database (AM or AMRT) that, in addition to the above, also contains reference mass spectral data, MS/MS, and/or MS<sup>n</sup> data on compounds.</li></ul><h3><strong>Multi-stage fragmentation in the mzCloud mass spectral library</strong></h3><div style="height:auto;" id="multistagefragmentation"><div><div><div><div><figure class="image"><img style="aspect-ratio:740/420;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_3_792a9d9a59.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: A schematic representation of a spectral tree within mzCloud. The MS spectra are acquired for a given compound in multiple polarities (ESI +/-), and for a range of adducts. Each precursor is exhaustively fragmented using different fragmentation techniques (CID, HCD) and at multiple collision energies to produce collections of fragmentation spectra at each fragmentation level (MS2, MS3, MS4 etc.), generating a comprehensive spectral tree of information for each library entry." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_3_792a9d9a59.jpg 245w," sizes="100vw" width="740" height="420"></figure><p>mzCloud is an<strong> all-encompassing mass spectral library </strong>with content based on a wide chemical space (therefore covering all small-molecule application areas), and acquiring high-resolution and accurate-mass data at various collision energies, for multiple adducts, using CID and HCD. Approximately 10–20 collision energies are included for every precursor ion; this multi-stage, multidimensional MS<sup>n</sup> spectral data are arranged into spectral trees, which are both extensive and comprehensive, typically containing many hundreds to thousands of spectra for each compound, with many exceeding MS<sup>4</sup> fragmentation steps.</p><p>The extensive data for each library entry is critical for accurate compound identifications, matching experimentally obtained data to that of the library contents, with fit confidence and data visualization <strong>provided in the</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong> Compound Discoverer</strong></a><strong> and </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1757"><strong>Mass Frontier</strong></a><strong> data analysis software.</strong> Additional tools in Compound Discoverer and Mass Frontier software, including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1762"><strong>mzLogic</strong></a>, use the extensive fragmentation information to confidently identify unknowns that cannot be identified based upon the spectral library compound entries alone.</p><h3><strong>Content curation in the mzCloud mass spectral library</strong></h3><div style="height:auto;" id="contentcuration"><div><div><div><div><figure class="image"><img style="aspect-ratio:740/342;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_4_c7064c2ca2.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: An example of the mass spectral content curation tool available within the Mass Frontier software. It contains all the functionality used to manually curate the content contained within mzCloud. The power of mzCloud lies in both the extent and high quality of its content, which helps make confident compound identifications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_4_c7064c2ca2.jpg 245w," sizes="100vw" width="740" height="342"></figure><p>Despite the fact that <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=orbitrap"><strong>Thermo Scientific Orbitrap-based mass analyzers</strong></a> routinely deliver sub 3-ppm mass errors, there is a small amount of inaccuracy in any experimental data used to search against a library; these errors would be compounded if the library itself also contained data with mass errors. The compounded errors would mean that any identifications could be harder to make or have lower confidence due to match scores being higher.</p><p>Curating the content within mzCloud guards against error and variability in the reference spectra against which data is compared. <strong>The process of curation involves:</strong></p><ul><li>Averaging multiple, individually acquired spectra</li><li>The removal of mass spectral noise</li><li>Recalibration of the mass spectra based upon the predicted formulas for the fragment ion elemental compositions, based upon the known elemental composition and structure of the precursor ion</li><li>Annotation of all fragment ions with the fragment structure</li><li>Addition of large amounts of metadata, including the source of the data and all original raw data files</li></ul><p>This curation process is performed <strong>for every spectra</strong> - every collision energy, every fragmentation type, every MS<sup>n</sup> level and for each precursor ion. As such, the spectral data in mzCloud is of <strong>exceedingly high quality </strong>and offers significant advantages over crowd-sourced libraries due to the high levels of control.</p><figure class="image"><img style="aspect-ratio:740/350;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_5_0c3fdc4c6c.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: A recalibrated fragmentation spectrum showing no error on the highlighted peak at m/z 213.05462, along with all of the annotation that is provided for each spectra, at each collision energy, for each fragmentation type at each MSn level." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_5_0c3fdc4c6c.jpg 245w," sizes="100vw" width="740" height="350"></figure><div><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><h3><strong>How can I use the mzCloud mass spectral library?</strong></h3><p>Accelerate your small molecule unknown identification studies with <strong>mzCloud</strong>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1762"><strong>mzLogic</strong></a>, and the other data analysis and mass spectral prediction tools available in<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Compound Discoverer</strong></a> software and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1757"><strong>Mass Frontier</strong></a><strong> </strong>software.</p><p><img style="aspect-ratio:860/261;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_7_a8cefb0028.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: Connectivity of mzCloud and mzVault to Mass Frontier." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_7_a8cefb0028.jpg 245w," sizes="100vw" width="860" height="261"></p><p>The content within mzCloud is accessible through Compound Discoverer and Mass Frontier software packages, provided you have an internet connection. No internet? No problem – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1760"><strong>mzVault</strong></a>, provides you with the MS and MS/MS content of mzCloud in an offline format.</p><div style="height:auto;" id="accessmzcloud"><div><div><div><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><p><img style="aspect-ratio:860/242;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_6_ae3c0a28e1.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: Connectivity of mzCloud and mzVault to Compound Discoverer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_6_ae3c0a28e1.jpg 245w," sizes="100vw" width="860" height="242"></p><p>Due to security concerns or local firewalls, not everyone can connect processing PCs to the internet. With that in mind, the contents of mzCloud are combined into an offline version twice a year. The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1760"><strong>mzVault</strong></a><strong> </strong>software application helps you access this information. In addition to accessing the offline version of mzCloud, the mzVault application can store and search your high-quality custom in-house (offline) MS/MS spectral libraries.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific Proteome Discoverer Software

Identify and quantify peptides and proteins in complex biological samples using Thermo Scientific™ Proteome Discoverer™ software. 

<h3><strong>Comprehensive, extensible, and intelligent platform</strong></h3><p><strong>Thermo Scientific Proteome Discoverer Software is the ultimate toolbox for protein research, offering customizable workflows tailored to the complexities of modern proteomics. It simplifies the identification and quantification of proteins in complex biological samples, supporting a wide range of workflows, including peptide and protein identification, post-translational modifications (PTM) analysis, isobaric mass tagging, and label-free quantitation (LFQ). It handles data from diverse acquisition methods, such as data-independent acquisition (DIA), data-dependent acquisition (DDA), and wide window acquisition (WWA), ensuring comprehensive coverage.</strong></p><p><strong>Advanced tools </strong>like INFERYS™ Rescoring and the CHIMERYS™ intelligent search algorithm by MSAID significantly increase identification rates, protein coverage, and the discovery of unique peptides and PTMs. The software enhances protein quantitation for isobaric mass tags and LFQ, supporting multiple database search algorithms and dissociation techniques. Whether analyzing glycopeptides, top-down proteomics, proteoforms, or MS-based structural biology like chemical cross-linking (XL-MS), Proteome Discoverer Software enables scientists to extract deeper biological insights from their data.</p><figure class="image"><img style="aspect-ratio:1131/598;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Proteome_Discoverer_Software_7_2221d76acd.jpg" alt="Thermo Scientific Proteome Discoverer Software: Proteome Discoverer software in peer reviewed articles." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Proteome_Discoverer_Software_7_2221d76acd.jpg 245w," sizes="100vw" width="1131" height="598"></figure><h3><strong>Key benefits</strong></h3><h5><strong>Customize your data analysis</strong></h5><p>Use the node-based workflow editor to customize your data analysis for maximum coverage and confidence. Integrate database search results from multiple search engines such as SEQUEST™ HT, Mascot, MSAmanda, Byonic™ from Protein Metrics, and<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1756"><strong>Thermo Scientific ProSightPD</strong></a> software. Increase confidence in peptide identification and quantification using INFERYS Rescoring and enable a deeper mining of your DIA, DDA, or WWA data using the CHIMERYS intelligent search algorithm.</p><h5><strong>Perform relative quantitation</strong></h5><p>Measure and report the relative expression levels of isotopically labeled peptides for:</p><ul><li>TMT SPS MS3</li><li>Glycopeptide identification and quantification</li><li>Phosphopeptide identification and quantification</li><li>Top-down proteomics</li><li>Cross-linking</li></ul><p>Confidently and efficiently interpret your data with integrated statistical and visualization tools for a faster time to meaningful results.</p><h5><strong>Extensible workflow tools</strong></h5><p>Utilize third-party nodes and build in customization with the scripting node, while maintaining full integration into the Proteome Discoverer software framework to leverage visualization, statistical analysis, and biological interpretation tools to take your analysis to the next level.</p><figure class="image"><img style="aspect-ratio:1160/533;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Proteome_Discoverer_Software_4_4d8ae8fcd2.jpg" alt="Thermo Scientific Proteome Discoverer Software: Extensibility - Connect to external tools via the Scripting Node; Integration with MSstatsTMT via custom script." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Proteome_Discoverer_Software_4_4d8ae8fcd2.jpg 245w," sizes="100vw" width="1160" height="533"></figure><h3><strong>Comprehensive tools for proteomic studies</strong></h3><p>With a wide range of database search options and the ability to combine the output from multiple algorithms, Proteome Discoverer software increases confidence in results and decision making through cross-validation. Augment searches with intelligent<strong> INFERYS Rescoring</strong> to increase confidence in peptide identification and quantitation. Whether you acquire your data in <strong>DIA, DDA, or WWA mode, CHIMERYS</strong> <strong>intelligent search algorithm </strong>helps you dig deeper into your data to substantially increase the number of unique peptide identifications, improve protein coverage, extend quantitation capabilities, and uncover new insights.</p><p>Complete sequence coverage and confident identification of post-translational modifications (PTMs) is realized with support for multiple dissociation techniques including collision-induced dissociation (CID), higher-energy collision-induced dissociation (HCD) and electron-transfer dissociation (ETD) in tandem with built-for-purpose search engines.</p><h3><strong>Customizable data analysis workflows</strong></h3><p><strong>Automate and simplify data analysis</strong> through customizable workflows including full support for multiple quantitative workflows. Enjoy experimental flexibility for quantitation by employing isobaric mass tagging with TMT and TMTpro reagent or other isotopic labeling strategies or utilize label-free quantitation techniques. Map quantitative data to biological information through study management and leverage fast, robust algorithms for peak selection and peptide quantification to extract the maximum possible information from quantitative proteomics studies.</p><p>Refine acquisition strategies by generating inclusion and exclusion lists that can be directly imported into instrument methods. Confidently and easily facilitate data comparison, exchange, and verification in compliance with data standards developed by the HUPO Proteomics Standards Initiative (PSI).</p><figure class="image"><img style="aspect-ratio:1232/459;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Proteomics_Software_Solution_98e62449c5.jpg" alt="Thermo Scientific Proteome Discoverer Software: The workflow system in Proteome Discoverer allows for customizable workflows to analyze complex proteomics data. The workflow system is composed of nodes that can connect in linear or branched pathways. While these workflows are highly customizable, pre-defined workflows for common workflows such as TMT, LFQ, PTM identification and cross-linked peptide ID are included." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Proteomics_Software_Solution_98e62449c5.jpg 245w," sizes="100vw" width="1232" height="459"></figure><h5><strong>Interactive enrichment table from graphical results to find overrepresented pathways</strong></h5><figure class="image"><img style="aspect-ratio:1344/924;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Proteome_Discoverer_Software_3_c01db3165a.jpg" alt="Thermo Scientific Proteome Discoverer Software: Interactive enrichment tables allow for the selection of up- or down-regulated proteins or peptides in any view, including volcano plots, PCA plots, and heat maps, and the visualization of corresponding Reactome pathways from the checked proteins to help derive biological interpretation of results. In addition to Reactome pathways, KEGG and Wikipathways as well as gene ontology terms and protein families can be visualized in the enrichment table." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Proteome_Discoverer_Software_3_c01db3165a.jpg 227w," sizes="100vw" width="1344" height="924"></figure><h5><strong>Pathway maps</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Proteome_Discoverer_Software_5_c087bb9d6f.jpg" alt="Thermo Scientific Proteome Discoverer Software: Pathways can also be directly visualized, providing biological context and background literature references using pathway maps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Proteome_Discoverer_Software_5_c087bb9d6f.jpg 245w," sizes="100vw" width="1119" height="584"></p><h5><strong>Interactive data visualization</strong></h5><figure class="image"><img style="aspect-ratio:973/879;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Proteome_Discoverer_Software_6_2b32110442.jpg" alt="Thermo Scientific Proteome Discoverer Software: Interactive data visualization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Proteome_Discoverer_Software_6_2b32110442.jpg 173w," sizes="100vw" width="973" height="879"></figure>

Thermo Scientific™ SimGlycan™ Software

SimGlycan software processes and interprets the multi-stage/sequential (MSn) data produced by Thermo Scientific™ Mass Spectrometers, a capability essential to determining glycan heterogeneity and isomeric forms.

<p><strong>Speed the characterization of complex glycans using SimGlycan™ software from PREMIER Biosoft. SimGlycan software processes and interprets the multi-stage/sequential (MS<sup>n</sup>) data produced by Thermo Scientific™ Mass Spectrometers, a capability essential to determining glycan heterogeneity and isomeric forms.</strong></p><p>The software automatically matches experimental mass spectra against a comprehensive database and generates a scored list of candidate structures.</p><h3><strong>Comprehensive Analyses</strong></h3><ul><li>Supports all Thermo Scientific ion trap and Orbitrap™-based instruments performing glycan characterization</li><li>Processes MS<sup>n</sup> data to resolve glycan heterogeneity, branching patterns, and isobaric structures. Up to seven levels of MS fragmentation can be needed to differentiate between glycan structural isomers</li><li>Includes a database of over 22500 glycans to process and verify structures</li><li>Provides a wealth of relevant biological information for the probable glycan structure, including glycan class, reaction, pathway, and enzyme</li><li>Searches for glycans with various chemical derivatives used for reducing end modifications, even if the derivative is not available in the database</li><li>Characterizes Na, Li, Mg, K, and formate adducts, and adduct combinations such as Na + H, Li + H, etc.</li><li>Identifies complex glycosaminoglycan structures, even when modified with substituents such as sulfate, phosphate, and ethanolamine</li><li>Determines cross-ring and double glycosidic cleavages, through a combination of permethyl derivatization and MS<sup>n</sup> data</li></ul><h3><strong>Powerful Reporting</strong></h3><ul><li>Creates reports that include glycan characteristics such as ID, sequence, name, composition, mass, precursor ion <i>m/z</i>, class, reaction, pathway, glycan image and theoretical fragments with corresponding mass and <i>m/z</i> values</li><li>Exports images of glycan structures, fragments, and spectra as JPEG or PNG files</li></ul>

Thermo Scientific LC-MS Data Processing Software

 Thermo Scientific LC-MS software streamlines data analysis with application-specific tools for -omics, pharma, and quant. Gain reliable insights to support decisions.

Thermo Scientific Ardia Platform

Built using cloud technology, the Ardia Platform centralizes information, including scientific data and results, maximizes instrument utilization, and accelerates data analysis to help scientists get closer to the truth.

<h3><strong>Bring your laboratory into a new era of connectivity with the Ardia Platform</strong></h3><p data-start="64" data-end="714"><strong>Digital transformation is a journey driven by the desire to fundamentally improve laboratory working practices by leveraging the latest advances in IT. The Thermo Scientific™ Ardia™ Platform allows the laboratory to harness the same technology.&nbsp;</strong></p><p data-start="64" data-end="714">In an era where laboratories are uncompromising in their pursuit of efficiency, the demand for software that seamlessly connects data, instruments, and scientists is on the rise.</p><p data-start="64" data-end="714">Built using cloud technology, the Ardia Platform centralizes information, including scientific data and results, maximizes instrument utilization, and accelerates data analysis to help scientists get closer to the truth.</p><figure class="image"><img style="aspect-ratio:1440/1127;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_2_4c83f21ef8.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_2_4c83f21ef8.jpg 200w," sizes="100vw" width="1440" height="1127"></figure><h5><strong>Centralize</strong></h5><p>Revolutionize data management by bringing together all your data sources, formats, and applications into one platform. With centralized data, you gain unprecedented control, accessibility, and efficiency, enabling you to make data‑driven decisions with confidence.</p><h5><strong>Unify</strong></h5><p>Say goodbye to the complexities of managing data scattered across various systems and locations. The Ardia Platform integrates with a growing list of software tools and applications for direct data access and automated data transfer, allowing you to harness the power of a unified platform and help eliminate data silos.</p><h5><strong>Streamline</strong></h5><p>Eliminate time‑consuming manual data transfers with automated workflows via the Ardia Platform’s Data Sync tool. Automatically transfer data to and from your repository for applications that are not yet connected so users can focus on what matters most.</p><h5><strong>Collaborate</strong></h5><p>Collaboration goes beyond just centralizing data and integrating software. With a single platform, you can easily share, access, and collaborate on data. Real‑time data updates, shared dashboards, and collaborative tools facilitate efficient teamwork, accelerating project timelines and driving innovation</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_57590fecf7.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_57590fecf7.jpg 245w," sizes="100vw" width="1022" height="450"></p><h3><strong>Data management</strong></h3><p>Securing, managing, and effectively utilizing large volumes of scientific data stored across multiple devices in different formats can be challenging and time-consuming.<br>The Ardia Platform offers robust data management capabilities that address these challenges. With automated central data storage, including backup and archival capabilities, and comprehensive access controls, users can securely access, view, and organize information from various applications more effectively.</p><blockquote><p><strong>webinar: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4962"><strong>Take control of your data and instruments</strong></a></p></blockquote><div><div data-message-author-role="assistant" data-message-id="ba34c04b-e6ae-4d15-ac9e-9e3606bb4933" dir="auto" data-message-model-slug="gpt-4o"><div><div><h4><strong>Centralize your data and enable accessibility and security</strong></h4><h5><strong>Manage</strong></h5><p data-start="64" data-end="990">The Ardia Platform provides secure, single‑point data management with automated transfer of data and results from <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Xcalibur™</strong></a><strong>,</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong> Compound Discoverer™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1782"><strong>Proteome Discoverer™</strong></a><strong>,</strong> and<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837"><strong>BioPharma Finder™ software</strong></a>, as well as third‑party application data via the Ardia Platform’s Data Sync functionality.<br>With single‑point data storage, users can enhance data accessibility, improve data organization and discovery, and reduce or eliminate data duplication.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_3_0ea16b74db.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_3_0ea16b74db.jpg 245w," sizes="100vw" width="1440" height="544"></p><h5><strong>Secure</strong></h5><p data-start="64" data-end="990">Keep data secure and controlled with user login access, system‑generated audit trails, and embedded user and data management tools, customizable to your organization’s specific needs. Streamline your operations and ensure disaster resilience through built‑in capabilities, such as tracking actions and simplifying data backup and archiving.</p></div></div></div></div><h3><strong>Ardia Platform’s Data Viewer</strong></h3><p>The intuitive, web‑based Ardia Platform’s Data Viewer tool provides a <strong>single location</strong> for review of chromatography and mass spectrometry data, delivering consistency across software products integrated with the Ardia Platform.<br>With a new user interface, it’s easy to display chromatograms and spectra, quickly create extracted ion chromatograms, perform peak integration, export spectral data to the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong>mzCloud™</strong></a> library for easy compound annotation, and view diagnostic channels like pump pressure for troubleshooting.<br>Expedite data review with user‑friendly features that include the ability to import a mass list, export plots in .svg format for high‑resolution visualizations, and quickly display linked data‑dependent acquisitions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_4_9d3c486827.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_4_9d3c486827.jpg 245w," sizes="100vw" width="1918" height="1012"></p><h3><strong>Instrument management</strong></h3><p>Managing a set of individual instruments is often a manual, time-consuming task. Bringing them together in one place, the Ardia Platform’s Instrument application enables monitoring and management of all connected instruments to maximize utilization and eliminate paper records.<br>This can significantly improve productivity by minimizing downtime, reducing delays, and improving lab efficiency.</p><h4><strong>Effective instrument management to drive laboratory productivity</strong></h4><h5><strong>Monitor</strong></h5><p>Easily view all connected systems from a central location with instrument cards providing real‑time status and data acquisition information for a holistic laboratory view to enable fast, informed decisions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_5_f985768d28.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_5_f985768d28.jpg 245w," sizes="100vw" width="1692" height="809"></p><h5><strong>Record</strong></h5><p>Digitize, standardize, and centralize instrument logbooks with automated event logging, plus manual entry tools to record maintenance activities, custom notes, and images. Automatic tracking of instrument module movements between systems assists laboratories in maintaining accurate and complete records, helping to ensure instruments are controlled and working properly, instilling confidence in result reliability. Instrument support is accelerated via in‑app service ticket and support package generation for immediate delivery to Thermo Fisher Scientific technical support.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_6_1a2b159f68.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_6_1a2b159f68.jpg 200w," sizes="100vw" width="873" height="680"></p><h5><strong>Schedule</strong></h5><p>Increase laboratory efficiency by optimizing instrument utilization. The Ardia Platform’s Instruments Scheduler tool provides a single point to plan work, view system availability, reserve time, and set maintenance windows on all connected instruments to minimize downtime.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_7_01ca77bc6d.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_7_01ca77bc6d.jpg 245w," sizes="100vw" width="1483" height="548"></p><h5><strong>Utilize</strong></h5><p>The Ardia Platform’s Data Insights application provides out‑of‑the‑box dashboards for key laboratory insights on resource availability, instrument status, and instrument performance in a centralized location. Track and monitor system metrics such as injection quantity, time, volume, type or status, and % utilization across systems and geographical locations. With interactive dashboards that can be filtered by system, system type, location, project, or time, you can easily focus on the metrics that matter most.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Ardia_Platform_8_3a6b276497.jpg" alt="Thermo Scientific Ardia Platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Ardia_Platform_8_3a6b276497.jpg 245w," sizes="100vw" width="1920" height="937"></p>

Thermo Scientific™ BioPharma Finder™ Software for the Characterization of Biotherapeutics

Simplify comprehensive biotherapeutic attribute characterization with advanced capabilities to increase throughput and confidence in a connected environment.

<div><div container-id="cq-colctrl-lt7" comp-id="A1"><div><p><strong>Discover how the features of Thermo Scientific BioPharma Finder Software are engineered to support the world of complex biopharmaceutical characterization. Featuring novel data processing algorithms and easy-to-interpret data visualization tools, the software supports users looking to confidently characterize biopharmaceuticals.</strong></p><p>Power BioPharma Finder&nbsp;Software with the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"> <strong>Thermo Scientific Ardia Platform</strong></a> to automate file centralization during acquisition, expand file access, enable report creation and result sharing, and remove data management barriers from your daily routine.</p><div><h3><strong>Key benefits</strong></h3></div><div><ul><li><strong>Confident characterization: </strong>Explore a solution for confident animo acid sequence characterization with the <strong>Peptide Mapping Analysis</strong> module featuring a novel MS<sup>2</sup> prediction algorithm.</li><li><strong>Customized Nucleotide sequence support:</strong> Leverage the ability to create customized nucleotide sequences to support confirmation with the <strong>Oligonucleotide Analysis </strong>module featuring an improved MS<sup>2</sup> fragmentation model (available in BioPharma Finder Software version 5.3).</li><li><strong>Efficient data handling:</strong> Move through vast amounts of data with remarkable efficiency using the <strong>Intact Mass Analysis</strong> module. With innovative deconvolution algorithms and features, you can generate multi-consensus reports effortlessly, providing a comprehensive view of your results.</li><li><strong>Unparalleled Modification Exploration and Flexibility: </strong>The <strong>Top-Down Analysis</strong> module empowers you to search through an extensive range of modifications, even at the per-peak level. With multiple fragmentation modes and a cross-array processing algorithm, you have the flexibility to explore your samples in greater detail.</li><li><strong>Seamless integration: </strong>See how easy it is to move from sophisticated characterization using BioPharma Finder Software to confident quantitation in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS software</strong></a> with benefits added by the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"><strong>Ardia Platform</strong></a> including connecting instrument data, supporting global access and centralizing BioPharma Finder reports.</li></ul><h3><strong>Learn more about BioPharma Finder Software</strong></h3><div><p>The<strong> right combination </strong>of data and software makes all the difference in accurately characterizing molecules, especially for large molecule.</p><h4><strong>Peptide mapping analysis</strong></h4><p>Characterization of a macromolecule comprised of an amino acid sequence can involve a lot of moving targets. Techniques for confident confirmation typically include comparisons of data collected against theoretical knowledge of the sequence. The best processing tools will also give users the ability to model probable sequences against the data collected with easy-to-use tools to increase the confidence of the identification and supply the summary reports with easy-to-interpret results.</p><div><h5><strong>Featured in the Peptide Mapping Analysis</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_b88e243207.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Processing with the novel MS2 algorithm in the Peptide Mapping Analysis module, generates a predictive model that includes Kinetical predictions that are compared with the measured spectra to increase confidence in the identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_b88e243207.jpg 245w," sizes="100vw" width="1160" height="540"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_2_6dda72b394.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  These processing tools, when combined, produce intuitive result review tools including comprehensive coverage maps, deep dive spectral comparison views and graphical sample comparison options." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_2_6dda72b394.jpg 245w," sizes="100vw" width="1160" height="600"></p><div><h5><strong>Detect and quantify host cell proteins</strong></h5></div><div><p>The sensitivity of the detection algorithm and prediction analytics allow for high confidence even for low abundance targets to support residuals applications like Host Cell Protein (HCP) analysis.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_3_e493898dc1.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Detect and quantify host cell proteins." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_3_e493898dc1.jpg 245w," sizes="100vw" width="1160" height="600"></p></div><h4><strong>Oligonucleotide analysis</strong></h4><div><p><strong>Sequence confirmation </strong>for oligonucleotides can be daunting. Take the question out of sequence confirmation with our enhanced MS<sup>2</sup> predictive algorithms that can iteratively create the best array of possibilities without iterating into infinity. Summarize your characterization with visual tools, generate easy-to-interpret results and enhance collaboration by saving and sharing reports in a connected environment.&nbsp;&nbsp;</p><h5><strong>Featured in the Oligonucleotide Analysis module</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_4_f709ce5528.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  The oligonucleotide sequence editor provides an easy-to-use interface for quickly and easily building and visualizing customized oligonucleotide sequences. Build out multiple expected sequences from custom building block subunits, a wide selection of modifications from the predefined list or with user-defined custom modifications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_4_f709ce5528.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_5_f204e2cd40.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  Eliminate alternative possibilities based on the entered sequence with the random sequence generator and leverage the in silico digest tools to support confident sequence verification - all using an updated MS2 prediction algorithm (available in BioPharma Finder Software version 5.3)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_5_f204e2cd40.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_6_f7f2d9e029.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  Perform mRNA mapping with selected in silico mRNA digestion or define the cleavage locations manually. Dig into the identity of fragments and expected or unexpected modifications and assess the overall coverage with intuitive visual coverage maps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_6_f7f2d9e029.jpg 245w," sizes="100vw" width="1160" height="600"></p></div><h4><strong>Intact mass analysis</strong></h4><div><div container-id="cq-colctrl-lt2" comp-id="B1"><div><p>Intact analysis on its face is a simple mathematical calculation used to deconvolute a series of m/z values into components but throw in the complexity of large molecule targets with modifications in a mixture of other like-molecules and mass accuracy becomes harder to achieve. No matter your data resolution,<strong> leverage innovative software tools engineered</strong> to filter and process through complex spectra with the <strong>Intact Analysis module.</strong> Discover how to quickly acquire and process batches of samples supported by a central data location on the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"><strong>Ardia Platform</strong></a> and speed through large batch-to-batch comparison studies to create summaries with connected multi-consensus reports.</p><div><h5><strong>Featured in the Intact Analysis module</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_7_72cfbd44c3.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  Accurately determine molecular weights utilizing the Sliding Window algorithm coupled with our optimized Xtract (for high resolution) and Respect (for lower resolution) deconvolution algorithms. Achieve comprehensive detection, even for co-eluting, low-intensity components in complex mixtures and account for any shifts in retention time." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_7_72cfbd44c3.jpg 245w," sizes="100vw" width="1160" height="323"></p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_8_d0c92fbca9.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  Use the expanded sequence matching capabilities for oligonucleotides which includes the ability to perform Terminal Truncation Searching from either the 3' or 5' terminus, facilitating the identification of impurities with greater ease. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_8_d0c92fbca9.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_9_d345484402.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  The intact mass analysis of heavily modified oligonucleotides presents analytical and data processing challenges due to the frequent usage of sulfur modifications. Pairing Thermo Scientific Orbitrap mass spectrometers with BioPharma Finder Software allows for confident intact mass identification of phosphorothioate conversion of oligonucleotides with less than 5 ppm error." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_9_d345484402.jpg 245w," sizes="100vw" width="1160" height="600"></p></div></div></div><h4><strong>Top-down analysis</strong></h4><div><div container-id="cq-colctrl-lt2" comp-id="B1"><div><p><strong>Higher order structure characterization</strong> requires a combination of some of the most variable sample treatment techniques, variable data acquisition techniques, and combined or complex data processing techniques. Looking to gently pry apart large complexes without reducing them to their smallest parts and understand them is an art and a science that can be supported by the <strong>Top-Down Analysis module</strong>. Explore the tools offered to help refine the field of predicted possibilities without restricting them, the support for multi fragmentation mode data, and the easy-to-use multi-consensus summaries to understand your molecule.</p><div><h5><strong>Featured in the Top-Down Analysis module</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_10_7e7ef85413.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  With the ProSightBP processing tool users can set variable or static sites for modification, select peak specific deconvolution parameters and even select peak specific sequence searching then let ProSightBP create the predictions. Combine the data from multi fragmentation modes including CID, HCD, ETD, EThcD, and UVPD resulting in confident identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_10_7e7ef85413.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_11_e3c9f5084b.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  Combining the predictive power of ProSight BP against the deconvoluted accurate mass with the sequence coverage from ETD and UVPD fragmentation reveals a comprehensive set of results to support confident molecule characterization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_11_e3c9f5084b.jpg 245w," sizes="100vw" width="1160" height="600"></p></div></div></div></div><h4><strong>Connecting to the Ardia Platform</strong></h4><div><p>Living in a world connected by networks that enable people to share everything doesn’t have to stop in the lab. With the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"><strong> Ardia Platform</strong></a> see how easy it can be to automatically centralize files, connect into those files from anywhere and process them with <strong>BioPharma Finder Software</strong> or any connected application.&nbsp;&nbsp;</p><div><h5><strong>Featured enhancements through connection</strong></h5><div><div container-id="cq-colctrl-lt2" comp-id="B1"><div><p><strong>Faster data review</strong></p><ul><li>Review a result generated by<strong> another colleague</strong> without having to import the results, open it from the shared secured Ardia Platform data repository, make comments or changes, and the software will automatically generate a new version to record the changes.</li></ul><p><strong>Better data management with centralized secured data</strong></p><ul><li>All results are <strong>securely </strong>saved in one place, no more finding the “right” computer or hard drive that contains the experiment and data.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_12_b6a814cd90.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  Keep data secure and controlled. Gain insights into file history, method history, and manage user access with control." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_12_b6a814cd90.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_13_1e3b879f18.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software:  Save and review individual reports without having to open BioPharma Finder Software for oligonucleotide, peptide mapping and intact mass applications. Utilize default reporting templates to speed development of customized reports and effectively modify templates to achieve desired result summary with the help of the customizable report designer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_13_1e3b879f18.jpg 245w," sizes="100vw" width="1160" height="600"></p><p>Enable collaboration on a global scale in a secure fashion to collaborate, compare, track, and finalize peptide results and workbooks using dynamic versioning history. Accelerate method optimization and review through a shared secure environment.</p></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific SII for Empower Software

Incorporate and operate Thermo Scientific UHPLC, HPLC, GC, and IC instruments within other vendors' software platforms with the Thermo Scientific™ SII for Empower 3 Software plug-in.

<div id="product-description"><p><strong>Incorporate and operate Thermo Scientific UHPLC, HPLC, GC, and IC instruments within other vendors' software platforms with the Thermo Scientific™ Standard Instrument Integration (SII) for Empower 3 Software plug-in. The SII for Empower 3 plug-in is based on the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</strong></a><strong> and offers unique and smart features that deliver maximum ease-of-use, reliability, and performance. It also enables Thermo Scientific™ chromatography systems to be operated and controlled by </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627"><strong>Waters™ Empower™ 3 CDS software</strong></a><strong>.</strong></p></div><div><p>While <strong>Chromeleon CDS</strong> is the recommended software for control of <strong>Thermo Scientific UHPLC, HPLC, GC, and IC </strong>instruments due to its maximum ease of use, reliability, and performance, other vendors' CDS software can also incorporate and operate these instruments with the <strong>SII for Empower™ 3 Software</strong> plug-in.</p><p>The SII for Empower™ Software installs and uses portions of<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS</strong></a>, such as the Services Manager, Instrument Configuration Manager, Instrument View, and Instrument Method Editor, to deliver flawless integration of Thermo Scientific LC, IC, and GC instrumentation into Empower™ 3 CDS without loss of functionality. Instrument control, data acquisition, and data processing are performed completely under Empower™ 3 Software.</p><p><strong>Configure your instruments</strong><br>Up to four instruments can be configured per Empower™ node using the standard Chromeleon Instrument Configuration Manager.</p><p><strong>Control your instruments</strong><br>SII for Empower™ Software provides a complete set of commands because they are present under native <strong>Chromeleon CDS </strong>control. For the user, this means that all the Chromeleon CDS tools and advanced features, such as preparing the next sample during an ongoing analysis, can be implemented to increase productivity and receive more data with fewer injections.</p><p><strong>SII for Empower™ controls the following systems:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;manufacturerItems=3&amp;search=Vanquish"><strong>Thermo Scientific™ Vanquish™ HPLC and UHPLC systems</strong></a></li><li><strong>Thermo Scientific™ UltiMate™ 3000 HPLC systems</strong></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/410"><strong>Thermo Scientific™ Dionex™ ICS-6000 HPIC™ system</strong></a></li><li><strong>Thermo Scientific™ Dionex™ ICS-5000 HPIC™ system</strong></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/408"><strong>Thermo Scientific™ Dionex™ Integrion™ HPIC™ system</strong></a></li><li><strong>Thermo Scientific™ Dionex™ Aquion™ system</strong></li><li><strong>Thermo Scientific™ TRACE™ 1300 GC systems</strong></li></ul><p>Monitoring instrument status within Empower™ can be performed using the <strong>Empower™ Control Panel. </strong>Here, an enhanced SII Instrument View is easily accessed to provide further options to control and monitor the instrument and its modules.</p><p><strong>Instrument Methods</strong><br>Setting up an instrument method is simple, intuitive, and fast due to the <strong>SII for Empower™ Instrument Method Wizard and Editor</strong>, both of which are integrated into the Instrument <strong>Method Editor of Empower™</strong>. The wizard guides the user through all modules, enabling the entry of all necessary information, while the editor allows the review and modification of all aspects of a method.</p><p><strong>Process your data</strong><br>Complete data processing takes place inside<strong> Empower™ Software</strong>, which allows you to use all functionalities as you would normally, for example, overlay of chromatograms or other channels like pressure traces. The Empower™ user experience <strong>does not change </strong>for any data processing aspect.</p></div>

Thermo Scientific LC-MS Data Acquisition Software

Acquire the highest quality data possible to unlock the information, knowledge, and value in your samples with Thermo Scientific LC-MS Data Acquisition Software.

Thermo Scientific™ Chromeleon™ XPS Open Access Software

Thermo Scientific™ Chromeleon™ XPS provides streamlined and easy-to-use interface for Thermo Scientific™ Chromeleon™ CDS, while maintaining full capabilities of the CDS software.

<p><strong>In modern laboratories, chromatography techniques and the use of mass spectrometry (MS) detection are in high demand. Until recently, MS detectors were regarded as sophisticated detection tools that could be operated only by a highly trained specialist. Nowadays mass spectrometers are increasingly used as straightforward detectors for chromatography.</strong></p><p>Alongside this move into routine use of MS is the continued deskilling of staff in the laboratory world, causing highly experienced chromatographers to be in short supply. The result is a substantial number of regular scientists and process operators that need to generate chromatographic results using advanced instrumentation themselves.</p><p>The solution is an Open Access tool enabling users to simply walk up and use a very straightforward interface to exploit the full power of the chromatography data system (CDS), without actually using the CDS software itself. <strong>Thermo Scientific™ Chromeleon™ XPS </strong>provides this <strong>streamlined and easy-to-use</strong> interface for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ CDS</strong></a>, while maintaining <strong>full capabilities</strong> of the CDS software, like instrument control, data processing, reporting and compliance tools.</p><h3><strong>Workflow</strong></h3><p>Users can walk up to <strong>any chromatography instrument</strong> connected to the CDS, with or without MS detection, and start to run their analysis with only a <strong>few mouse-clicks.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5e8f8c3dec.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: First, select the analysis to perform (A) and which instrument should be used (B). The instrument overview shows the current instrument status’ and displays the estimated wait time until each instrument is available and the number of sample positions still available.  The instrument list is filtered depending on the analysis selected and the users privileges to only show appropriate instruments." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5e8f8c3dec.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_2_a8b64a52ae.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: Next, enter the sample names (C) and any other parameters (D) required for the analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_2_a8b64a52ae.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_3_4b4367ffae.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: Place the sample vials in the indicated positions and select Submit." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_3_4b4367ffae.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_4_0386d31c9a.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: The sequence is submitted and will run. The operator is shown the expected start and finish time of the analyses." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_4_0386d31c9a.jpg 245w," sizes="100vw" width="625" height="263"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5_1b51ab8dd2.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: At the end of the run, the results are automatically printed and/or exported and a link to the exported report can be distributed via email." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5_1b51ab8dd2.jpg 245w," sizes="100vw" width="814" height="309"></p><h3><strong>Configuration and management</strong></h3><p>Running samples is as easy as described above once Chromeleon XPS software is set up, configured and managed by an experienced chromatographer.</p><ul><li>All the methods required for the analysis must be created; the instrument method with all instrument control and data acquisition parameters, the processing method with all data processing parameters and the report template with all required results, to be reported.&nbsp;</li><li>A Chromeleon eWorkflow is created using these methods. An eWorkflow is an electronic procedure that automates all steps of the laboratory process related to a chromatographic analysis</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_6_a3b2219e42.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: The lab manager can customize Chromeleon XPS to show or hide individual toolbar buttons (A), which eWorkflows are visible to users (B) and which instruments they can access (C)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_6_a3b2219e42.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_7_d647111f5d.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: In addition, it is possible to define various system options, such as which email notifications to send." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_7_d647111f5d.jpg 193w," sizes="100vw" width="659" height="533"></p><p>Chromeleon XPS Open Access software lets <strong>any user</strong> run samples on their own by delivering a <strong>clean, streamlined walk-up interface</strong> that utilizes the<strong> full power</strong> of Chromeleon CDS. Users can access<strong> all instruments controlled by </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS</strong></a><strong>, including MS</strong>, and automatically receive results or notifications about run completion or failure. The management console contains advanced customization options to fulfill any organization’s requirements, included fully regulated environments.</p><p><strong>Chromeleon XPS software provides error-free execution of any chromatography analysis with minimal training requirements for users.</strong></p>

Thermo Scientific LCQUAN Quantitative Software

LCQUAN is a robust, 21 CFR Part 11-compliant software for LC-MS/MS bioanalysis, providing complete tools for data acquisition, review, and secure management in drug development workflows.

<h4><strong>21 CFR Part 11-compliant software for quantitative LC-MS/MS data acquisition and management</strong></h4><p><strong>Thermo Scientific™ LCQUAN™ quantitative software is a robust, regulatory-compliant data system tailored for bioanalytical laboratories conducting LC-MS/MS assays. Developed in close collaboration with pharmaceutical industry experts, LCQUAN provides all the tools needed to acquire, process, review, and securely manage quantitative data across global drug development workflows.</strong></p><h3><strong>Key Features</strong></h3><h4><strong>Regulatory Compliance</strong></h4><ul><li>Fully compliant with FDA 21 CFR Part 11 requirements for electronic records and signatures</li><li>Enables secure submission of electronic documents to regulatory agencies, including the FDA</li></ul><h4><strong>Comprehensive Workflow</strong></h4><ul><li>Guides users step-by-step through acquisition, method development, data review, processing, reporting, and export</li><li>Supports import of sequence information from external systems</li><li>Streamlines interaction with Thermo Scientific™ Watson LIMS™ for GLP-compliant bioanalytical studies</li></ul><h4><strong>Secure Data Management</strong></h4><ul><li>Enables data processing on networked systems, including secure remote disks</li><li>Centralized, workbook-style data storage for easy archiving and retrieval</li><li>Multi-level user privileges—from full system access to read-only modes</li></ul><h4><strong>Seamless LIMS Integration</strong></h4><ul><li>Bi-directional communication with Watson LIMS facilitates study tracking, chromatogram review, auditing, and compliance</li><li>Optimized for regulated pharmaceutical workflows from discovery through clinical trials</li></ul><h4><strong>Proven Platform</strong></h4><ul><li>Part of an integrated Thermo Scientific LC-MS/MS solution suite, including TSQ Series mass spectrometers and FAIMS interface technology</li><li>Ensures high sensitivity, robustness, and reproducibility for regulated bioanalytical assays</li></ul>

Products focused on Software from Thermo Fisher Scientific distributed by Thermo Fisher Scientific (EMEA) - page 1

Related content

Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation

Awards at the 44th International Symposium on Capillary Chromatography and 21st GCxGC Symposium

ISC 2026 Early-Bird Registration & Payment Deadline