Meeting EU Drinking Water Standards: The Critical Role of Sample Prep in Trace Contaminant Analysis

Although modern agriculture needs to be based on accurate real-time data on soil, plant, and environmental conditions, affordable, sufficiently sensitive, and robust monitoring devices for this purpose are currently missing. According to scientists, low-cost sensors based on new smart materials and printing technologies offer a suitable solution. The results of multidisciplinary research thus far and proposals for the development of these devices have been presented by researchers from Czechia, Great Britain, Spain, and the USA in a review article in the prestigious journal <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1">Nature Communications</a>.“Sensor technologies for monitoring plant health are still in their infancy. Only simple sensors capable of monitoring basic parameters such as pH, soil moisture, or temperature are commonly available on the market. However, if farmers are to face current challenges, including climate change, and ensure sufficient food for humanity, they need much more effective tools that will enable them to monitor, for example, various pathogens, including bacteria and fungi. In our opinion, a suitable solution is a combination of new smart materials and printing for the production of inexpensive, durable, and scalable materials,” said the article’s first author, David Panáček from CATRIN, who worked on the study during his internship at Imperial College London.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152">Sensors for monitoring plant health, for example, lag behind similar devices used in human medicine. According to the authors, advances in materials science, which will enable the development of scalable sensor technologies, play a key role in this potential shift. “Printing techniques, including inkjet printing, screen printing, aerosol printing, 3D printing, and direct laser writing, offer flexible ways to produce flexible sensors, large-area sensors, and sensors integrated directly into plants. The review article summarizes recent advances in printable low-dimensional materials for agricultural sensors, analyzes their physico-chemical properties in relation to sensor performance, and discusses key challenges and future opportunities requiring interdisciplinary integration,” said one of the corresponding authors, Michal Otyepka.The research brought together materials scientists, chemists, biologists, sensing experts, and printing technology specialists. Materials research and the use of graphene-based smart materials were led by scientists from CATRIN at Palacký University and VŠB-Technical University of Ostrava. Plant biologists from CATRIN contributed their knowledge of plant development, their responses to stress conditions, and the monitoring of their properties. Researchers from Imperial College London took care of the electronics, while representatives from<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/36"> CEITEC – VUT</a> focused on printing technologies. The team also included leading experts in sensing from the Catalan Institute of Nanoscience and Nanotechnology in Barcelona, and Joseph Wang of the University of California San Diego, the “father of sensing and electrochemistry,” also contributed his extensive knowledge.“This is a groundbreaking study on this topic, which has managed to attract some truly big names in their respective fields. Last but not least, the study demonstrates that interdisciplinarity at CATRIN gives rise to completely new and promising research topics, such as plant sensing and its use for studying plant-environment interactions and smart agriculture,” added another corresponding author, Nuria De Diego.

Current sensors are not good enough. Scientists propose a new way to monitor plant health

In this episode of the Concentrating on Chromatography podcast, host David Oliva interviews Ainslie Chen about her cutting-edge research on hemoglobin variant testing using liquid chromatography-high resolution mass spectrometry (LC-HR-MS). Ainslie discusses her novel method for separating and identifying hemoglobin subunits with mass shifts less than 1 Da, overcoming critical limitations in conventional clinical assays.Hear firsthand how her team developed an LC-HR-MS workflow using a C4 reversed-phase column, tackled technical challenges (including why C18 columns fell short), and achieved unprecedented sensitivity for variant detection in both adult and neonatal samples. The conversation touches on the potential of mass spectrometry to revolutionize clinical diagnostics, the importance of reproducibility, barriers to adoption in routine labs, and how teamwork drives scientific innovation.Perfect for analytical chemists, clinical laboratorians, and anyone interested in the future of protein variant analysis, this episode also features Ainslie’s advice for early-career scientists and insights from her first ACS poster presentation.<h4>Key Highlights:</h4><ul><li>Motivation behind improving hemoglobinopathy testing &nbsp;</li><li>Technical advantages of LC-HR-MS over gene sequencing and CE &nbsp;</li><li>The crucial role of the C4 column in resolving challenging samples &nbsp;</li><li>Critical parameters for reproducible LC-HR-MS workflows &nbsp;</li><li>Barriers and outlook for clinical adoption of advanced mass spectrometry &nbsp;</li><li>The value of teamwork and mentorship in scientific research &nbsp;</li><li>Direct insights from recent ACS conference experiences</li></ul><h3>Video transcription</h3>In this interview, Ainslie Chen discusses her research on improving the detection and identification of hemoglobin variants using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). The work addresses limitations of conventional hemoglobinopathy testing, which often struggles to resolve very small mass differences between closely related hemoglobin subunits. Because even a single amino-acid substitution can significantly alter hemoglobin structure and function, high analytical resolution is essential for accurate diagnosis of conditions such as anemia and sickle cell disease.Chen explains why her team selected LC-HRMS over established clinical techniques like capillary electrophoresis and gene sequencing. While sequencing offers excellent accuracy, it is time-consuming, costly, and requires extensive sample preparation, making it impractical for routine clinical workflows. Capillary electrophoresis enables subunit separation but lacks the resolving power needed to distinguish variants differing by less than one Dalton. In contrast, high-resolution mass spectrometry provides both structural specificity and sensitivity, enabling confident identification of subtle hemoglobin variants with minimal sample preparation.A key methodological insight from the project was the use of a C4 reversed-phase LC column instead of the more common C18 column. Chen describes how the shorter carbon chain and larger pore size of C4 columns improved protein elution and reduced denaturation, leading to more reproducible separations. Critical parameters for reproducibility included consistent mobile-phase composition (0.1% formic acid in water and acetonitrile), controlled temperature (60 °C for LC, ~320 °C capillary temperature), and stable chromatographic conditions.Beyond hemoglobin analysis, Chen highlights the broader potential of high-resolution mass spectrometry in proteoform analysis and clinical diagnostics, including emerging applications in cancer detection. She acknowledges current barriers to clinical adoption—such as energy demands and instrument infrastructure—but points to advances like miniaturized mass spectrometers as promising steps toward wider use. The interview concludes with advice for young scientists: don’t hesitate to reach out to mentors, embrace collaboration, and view analytical chemistry as a versatile tool that bridges medicine, biology, environmental science, and beyond.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Unlocking Hemoglobin Variant Detection: LC-HR-MS Breakthrough with Ainslie Chen

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Video

Environment

Scientific article

Interview

Science and research

The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Thermo Scientific Accucore C8 HPLC Columns

Improve separation speed and resolution while maintaining low backpressures using Thermo Scientific™ Accucore™ C8 LC Columns. 

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Thermo Scientific Accucore aQ C18 Polar Endcapped HPLC Columns

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Separate polar compounds with improved speed and resolution using Thermo Scientific™ Accucore™ aQ C18 Polar Endcapped LC columns. Rugged 2.6μm solid-core particles enable fast, high-efficiency separations at low backpressures.The polar endcapped C18 stationary phase provides optimal retention of polar analytes and is fully compatible with 100% aqueous mobile phases. Robust bonding technology and automated packing procedures ensure excellent reproducibility and long column lifetimes.<h5>Alternative Selectivity</h5><ul><li>Polar endcapped C18 stationary phase provides optimum retention of polar analytes</li><li>Accucore aQ Columns are compatible with highly aqueous mobile phases.</li><li>Polar encapping allows use in 100% aqueous mobile phases without loss of performance or stability.</li></ul><h5>Fast Separations</h5><ul><li>2.6μm core-enhanced technology particles enable operation at high flow rates without generating excessive backpressures.</li></ul><h5>Excellent Peak Shapes for Enhanced Resolution and Sensitivity</h5><ul><li>Solid-core 2.6μm particles and narrow particle size distribution reduce band broadening and improve separation efficiencies.</li><li>High surface coverage of silica minimizes secondary interactions and peak tailing.</li></ul><h5>Low Backpressures</h5><ul><li>Solid-core 2.6μm particles for less backpressure compared to UHPLC sub-2μm particles</li><li>Compatible with conventional HPLC instrumentation and UHPLC platforms</li></ul><h5>Excellent Reproducibility and Robustness</h5><ul><li>Advanced bonding technology</li><li>Automated packing process</li></ul><h4>Specifications</h4><ul><li>Endcapped: Polar</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Particle Shape: Spherical Solid Core</li><li>Stationary Phase: C18</li><li>Surface Area: 130 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L1</li><li>Carbon Load: 9%</li><li>Phase: Reversed Phase</li><li>Pore Size: 80 Å</li><li>pH: 2 to 9</li></ul>

Thermo Scientific Accucore Polar Premium HPLC Columns

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Achieve fast, high-resolution separations of polar and nonpolar analytes using Thermo Scientific™ Accucore™ Polar Premium LC columns. Rugged 2.6μm solid-core particles enable fast, high-efficiency separations at low backpressures.&nbsp;The robust amide-embedded C18 stationary phase provides unique selectivity complementary to conventional C18 columns, is stable from pH 1.5–10, and is fully compatible with highly aqueous mobile phases. Robust bonding technology and automated packing procedures ensure excellent reproducibility and long column lifetimes.<h5>Alternative Selectivity</h5><ul><li>Polar embedded reverse phase material offers complementary selectivity to standard C18 columns.</li></ul><h5>Stable over Wide pH Range</h5><ul><li>Specially designed bonded phase is stable from pH 1.5–10.5.</li></ul><h5>Compatible with Highly Aqueous Mobile Phases</h5><ul><li>Rugged amide-embedded C18 phase will not undergo phase collapse in 100% aqueous mobile phase.</li></ul><h5>Fast Separations</h5><ul><li>2.6μm core-enhanced technology particles enable operation at high flow rates without generating excessive backpressures.</li></ul><h5>Excellent Peak Shapes for Enhanced Resolution and Sensitivity</h5><ul><li>Solid-core 2.6μm particles and narrow particle size distribution reduce band broadening and improve separation efficiencies.</li><li>High surface coverage of silica minimizes secondary interactions and peak tailing.</li></ul><h5>Low Backpressures</h5><ul><li>Solid-core 2.6μm particles for less backpressure compared to UHPLC sub-2μm particles</li><li>Compatible with conventional HPLC instrumentation and UHPLC platforms</li></ul><h5>Excellent Reproducibility and Robustness</h5><ul><li>Advanced bonding technology</li><li>Automated packing process</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Particle Shape: Spherical Solid Core</li><li>Stationary Phase: Polar Embedded</li><li>Surface Area: 90 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L60</li><li>Carbon Load: 9%</li><li>Phase: Reversed Phase</li><li>Pore Size: 150 Å</li><li>pH: 1.5 to 10.5</li></ul>

Thermo Scientific Accucore Phenyl-Hexyl HPLC Columns

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Offer unique selectivity for aromatic and moderately polar analytes with Thermo Scientific™ Accucore™ Phenyl-Hexyl LC Columns.Based on Core Enhanced Technology, Accucore columns provide fast, high-resolution separations without the elevated backpressures required by sub-2μm particles.<ul><li>Fast separations with excellent resolution and sensitivity</li><li>Lower backpressures so that UHPLC is not required</li><li>Mixed-Mode Selectivity for Aromatic and Moderately Polar Analytes</li><li>Enhanced Pi-pi Interactions with Aromatics</li><li>Moderate Hydrophobicity</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>For Use With: HPLC</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Particle Shape: Spherical Solid Core</li><li>Stationary Phase: Phenyl/Hexyl</li><li>Surface Area: 130 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L11</li><li>Carbon Load: 5%</li><li>Phase: Reversed Phase</li><li>Pore Size: 80 Å</li><li>pH: 2 to 8</li></ul>

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer confidently and routinely characterize, quantify, and confirm in a single analysis using a single mass spectrometer.

Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.<h5>Superior Quantitation</h5><ul><li>Advanced quadrupole technology (AQT) improves precursor selection and transmission for more-accurate quantitation of low-abundance analytes in complex matrices</li><li>Sophisticated data-independent acquisition (DIA) and parallel reaction monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence</li><li>An advanced active beam guide (AABG) reduces noise and extends maintenance intervals</li></ul><h5>Enhanced Analysis of Intact Proteins</h5><ul><li>Optional intact protein mode provides superior trapping of large molecules for improved analysis of intact proteins and protein complexes</li><li>Optional enhanced resolution ensures maximum ID confidence in top-down proteomics and lipidomics</li></ul><h5>High-Confidence Results</h5><ul><li>HR/AM and full-scan capabilities capture all sample data, all of the time, enabling retrospective data analysis without need to re-run samples</li><li>Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices</li><li>Better than 1-ppm mass accuracy in full- and all-ion fragmentation (AIF) scan modes ensures confident compound identification</li><li>Fast scanning at 12 Hz and spectral multiplexing suited to UHPLC applications</li><li>Rapid polarity switching maximizes information obtained</li><li>AIF and multiple dissociation techniques — in-source CID and HCD — aid in compound identification</li><li>Mass range to 6000 m/z enhances detection of singly charged small molecules and biomolecules</li><li>More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan</li></ul>

Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer

Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS offers ultra-high mass range native MS with top-down capabilities, extreme sensitivity, and resolution up to 80,000 m/z.

<h3>Go beyond what you thought possible with native mass spectrometry</h3>The Thermo Scientific™ Q Exactive™ UHMR is the first hybrid quadrupole-Orbitrap™ mass spectrometer designed specifically for ultra-high mass range (UHMR) native MS and top-down protein analysis. It combines exceptional sensitivity, ultra-high resolution at high m/z, and unique pseudo-MS³ capabilities, enabling detailed characterization of intact protein assemblies and complex biological systems.<h3>🔬 Breakthrough in Native Mass Spectrometry</h3>Native mass spectrometry preserves the non-covalent structure and interactions of proteins and protein complexes, making it an indispensable tool for structural biology and biopharma. The Q Exactive UHMR system enables direct mass analysis of intact macromolecules, including membrane proteins, virus capsids, and ribosomal particles—with unrivaled detail.<ul><li>Ultra-high mass range detection up to 80,000 m/z</li><li>Native top-down analysis of protein complexes and assemblies</li><li>High sensitivity for precious or low-abundance samples</li><li>Resolve mass differences even in heterogeneous megaDalton assemblies</li></ul><h3>⚙️ Technological Innovations</h3>The Q Exactive UHMR system integrates multiple hardware advancements to overcome the historical limitations of native MS:<ul><li>In-source trapping for efficient desolvation and controlled dissociation</li><li>Advanced quadrupole mass filter with selection up to 25,000 m/z</li><li>Reduced RF frequencies across the ion path for better high-mass transmission</li><li>Pseudo-MS³ capability: fragment large complexes into subunits, then sequence them in HCD cell</li></ul><h3>🧬 Applications and Capabilities</h3><h4>Confident characterization of complex biological systems:</h4><ul><li>Virus capsid analysis: Differentiation and sequencing of 3–4 MDa hepatitis B virus capsids</li><li>Ribosome studies: Resolution of substoichiometric proteins in E. coli 70S particles</li><li>Membrane proteins: Gentle liberation from micelles and native top-down sequencing (e.g., AmtB trimer)</li><li>Chaperonin complexes: Native top-down analysis of GroEL tetradecamer</li></ul><h4>Detect and resolve small differences in high-mass species:</h4><ul><li>Post-translational modifications</li><li>Ligand binding</li><li>Protein truncations and isoforms</li></ul><h3>💡 Software for Confident Data Interpretation</h3>Maximize the power of native MS with industry-leading software:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837">BioPharma Finder™ Software </a>– For intact mass confirmation, top-down analysis, and PTM localization</li><li>ProSightPC™ Software – Advanced top-down proteomics with integrated UniProt database search</li></ul><h3>🧪 Who Is It For?</h3>Ideal for research groups and industry labs focused on:<ul><li>Structural biology</li><li>Biotherapeutic development</li><li>Native and top-down proteomics</li><li>Protein-ligand interaction studies</li></ul><h3>🧭 Summary of Key Features</h3><ul><li>Mass range: Up to 80,000 m/z</li><li>Quadrupole isolation: Up to 25,000 m/z</li><li>Sensitivity: Orders of magnitude higher at high m/z</li><li>Fragmentation: HCD, pseudo-MS3 for native top-down</li><li>In-source trapping: Yes, optimized for membrane protein assemblies</li><li>Software: BioPharma Finder, ProSightPC</li><li>Compatible analyses: Native MS, top-down, intact mass, charge detection</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp" alt="Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/thumbnail_Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp 156w," sizes="100vw" width="650" height="650">

Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer

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Designed to unravel complex chemical structures while delivering the highest versatility and comprehensive workflow support for unknown compound ID and small molecule analysis, the Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ mass spectrometer empowers you to collect more meaningful data.Combining industry-leading mass analyzer technology analysis with intelligent acquisition, intuitive software and remote, hands free calibration, discover a new level of improved confidence in structure elucidation, with on-the-fly identification of small molecules to reveal more chemical structures with ease.The Orbitrap IQ-X Tribrid MS seamlessly integrates with industry-leading solutions to provide a complete workflow solution, including Thermo Scientific™ Vanquish™ Duo UHPLC Systems, Thermo Scientific™ FAIMS Pro Duo interface for differential ion mobility, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759">Thermo Scientific™ Compound Discoverer™ data analysis software</a>, and the most comprehensive spectral libraries available on <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764">Thermo Scientific™ mzCloud™</a>, enabling an intelligent MSⁿ data acquisition strategy to easily conduct small molecule structural elucidation, identification, and characterization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp 238w," sizes="100vw" width="1447" height="949"><h5>Other benefits of this mass spectrometry system include:</h5><ul><li>A combination of the best of quadrupole, linear ion trap and Thermo Scientific™ Orbitrap™ mass analyzer technology for acquisition of the richest MSⁿ data per sample.</li><li>Spend more time on results, less time on instrument set-up with the new Auto-Ready ion source for remote, hands free calibration, combined with the Thermo Scientific™ EASY-IC™ (Internal Calibration) source to deliver superior mass accuracy in every scan, mass calibration can be fully automated, increasing productivity.</li><li>Real-Time Library Search provides higher confidence small molecule analysis using on-the-fly spectral matching for decision-based triggering of MSⁿ scan events that increase certainty.</li><li>Expanded <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1763">Thermo Scientific™ AcquireX workflow</a> capabilities provide easy and intelligent acquisitions to find more compounds by integrating independent experiments into an automated workflow for efficient and comprehensive sample and study characterization.</li><li>Flexible fragmentation choices for structural determination of lipids, metabolites, and other small molecules utilizing Collision induced dissociation (CID), Higher-energy collisional dissociation (HCD) and optional Ultraviolet Photodissociation (UVPD).</li><li>Improved unknown analysis and fine isotope detection with optional 1,000,000 (1M) FWHM resolution at m/z 200.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1880" height="822"><h3>Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer Specifications</h3><ul><li>Dimensions (D x W x H): 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li>Dynamic Range: &gt;5000 within a single scan</li><li>Mass Accuracy:&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li>Polarity Switching: One Full Cycle in 1.1 sec</li><li>Scan Rates:&nbsp;<ul><li>OTMSⁿ: Up to 40 Hz</li><li>ITMSⁿ: Up to 45 Hz</li></ul></li><li>Weight (Metric): 318 kg (700 lb.)</li><li>Mass Range: Full MS Mass Range: 50 to 2000 m/z to MSⁿ Mass Range: 40 to 2000 m/z</li><li>Max. Resolution: Up to 500,000 at m/z 200</li><li>Resolution:&nbsp;<ul><li>7500 to 500,000 (FWHM) at m/z 200</li><li>1M Option: up to 1,000,000 (FWHM) at m/z 200</li></ul></li><li>Type: Orbitrap IQ-X Tribrid MS IC</li><li>Unit Size: Each</li></ul>

Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer

With enhanced performance and usability, the Orbitrap Eclipse Tribrid MS makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.

Introducing the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer, our newest generation instrument designed with your most difficult analytical challenges in mind. With enhanced performance and usability, the Orbitrap Eclipse Tribrid mass spectrometer makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.Obtain high confidence insights for very complex molecules with the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer. It combines industry-leading versatility and usability with the exceptional performance afforded by its built-in intelligence and revolutionary Thermo Scientific™ Tribrid™ architecture to deliver an instrument designed to address the most difficult analytical challenges.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp 245w," sizes="100vw" width="596" height="310"><h5>This newest Tribrid platform includes:</h5><ul><li>Advanced Ion Management Technology (AIM+) with the new QR5 segmented quadrupole mass filter</li><li>Real-Time Search</li><li>Enhanced Vacuum Technology</li><li>Optional Proton Transfer Charge Reduction (PTCR)</li><li>Optional High Mass Range MSⁿ (HMRⁿ) mode</li></ul><h5>Collectively, these features make this instrument uniquely suited for:</h5><ul><li>Accurate and high-throughput full-proteome quantitation</li><li>Characterization of complex mixtures of protein or small molecule-based pharmaceuticals</li><li>Deciphering higher-order protein structures</li></ul>The Orbitrap Eclipse Tribrid MS makes it easy to tackle these difficult analyses and collect the high-quality data required to drive the right decisions, pushing your science beyond today's discovery.With its built-in intelligence and versatility, the Orbitrap Eclipse Tribrid MS makes it easy to produce the high quality data required to drive the right decisions.<ul><li>Exceptional precursor selectivity and sensitivity with the next generation quadrupole mass filter</li><li>Unmatched depth and accuracy of TMT analysis with novel Real-Time Search</li><li>High Mass Range MSⁿ (HMRⁿ) option for comprehensive analysis of native protein complexes</li><li>Unique Proton Transfer Charge Reduction (PTCR) option for simplifying complex top-down spectra</li><li>Full experimental flexibility with revolutionary instrument control</li><li>A wide range of optional functionalities for unprecedented versatility</li><li>Common user interface with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/401">Thermo Scientific™ Orbitrap Exploris™ 480</a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=TSQ">TSQ™ triple quadrupole mass spectrometers</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1452" height="710"><h3>Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer Specifications</h3><ul><li>Dimensions (D x W x H): 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li>Dynamic Range: &gt;5000 with a single OTMS spectrum</li><li>Mass Accuracy:&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li>Model: Tribrid MS</li><li>Polarity Switching: One Full Cycle in &lt; 1.1 sec</li><li>Scan Rates:&nbsp;<ul><li>OTMSⁿ: Up to 40 Hz</li><li>ITMSⁿ: Up to 45 Hz</li></ul></li><li>Weight (Metric): 180 kg (400 lb.)</li><li>Mass Range:&nbsp;<ul><li>Standard mass range: 50 to 2000 m/z</li><li>Mid mass range: 200 to 6000 m/z</li><li>Optomenal HMRⁿ mass range: 500 to 8000 m/z</li></ul></li><li>Max. Resolution: Up to 500,000 at m/z 200</li><li>Type: Orbitrap LC-MS</li><li>Unit Size: Each</li></ul>

Thermo Scientific Chromeleon CDS Enterprise

Chromeleon CDS Enterprise is a scalable, cloud-ready chromatography data system for multi-site labs. Ensures compliance, connectivity, uptime, and productivity.

A Chromatography Data System (CDS), networked or enterprise, is vital for compliant, efficient and reliable operation of any modern chromatography laboratory – it will manage all the analytical processes from instrument control, to raw data storage and processing, right through to generating the final results.Delivering these capabilities across a network brings a unique set of challenges. <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ CDS</a> has been designed and optimized to overcome these challenges. The Chromeleon software architecture can connect multiple sites and locations to a central data center with the same performance as a fully local operation. With its forward-looking architecture Chromeleon CDS is cloud-ready today.Chromeleon software supports your chromatography operation throughout your enterprise – from research to routine quality testing – connecting people, instruments and other laboratory software, while delivering proven productivity gains for faster return on investment (ROI).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/Thermo-Chromeleon-CDS-Enterprise-2.jpg" alt="Thermo Scientific Chromeleon CDS Enterprise" width="null" height="null"><h3>Chromeleon CDS brings…</h3><h4>…compliance</h4><ul><li>Highest degree of data integrity and traceability with comprehensive security tools</li><li>eReports and eSignatures ensure regulatory compliance</li><li>Automated software and instrument qualification routines and qualification monitoring</li><li>Supports GLP, GMP and 21 CFR Part 11 regulatory requirements</li><li>Complete audit trails with versioning and advanced review functions</li></ul><h4>…connectivity</h4><ul><li>Built for scalable network deployment</li><li>Utilize instruments suiting your business’s needs</li><li>Easily interface with relevant laboratory software (including LIMS/ELN)</li><li>Chromeleon SDK available for custom integrations</li><li>Cloud-ready with central management and simplified deployment</li></ul><h4>…confidence</h4><ul><li>Unique network failure protection ensures 24/7 laboratory uptime</li><li>Future proof and scalable software solution</li><li>Access to up-to-date laboratory performance information</li><li>XVault technology enables operation even during network outages</li><li>Automatic instrument and software qualification checks</li></ul><h4>…productivity</h4><ul><li>Increased efficiency via toolset providing ‘right first time’ analysis</li><li>Reduced data processing time using built-in smart tools</li><li>eWorkflow™ procedures, Smart Startup, IRC and SST automation</li><li>SmartLink, Cobra Wizard and batch processing tools for fast, reliable data review</li><li>Fully customizable Report Designer and structured reporting templates</li></ul>

Thermo Scientific Vanquish Duo UHPLC Systems

A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance.

<h3>Optimize your productivity</h3>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;At the same time, advancements and innovations are needed to improve operational efficiency and performance. How do you accomplish this? It’s easy with the Thermo Scientific™ Vanquish™ High-throughput LC systems built for enhanced productivity. Vanquish High-throughput LC systems combine individual Vanquish components and software wizards to deliver increased throughput or detector utilization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"><h3>Two flow paths for maximized productivity</h3>Your laboratory may be facing increased pressure to improve working efficiency and deal with limiting resources, such as budget, space, or manpower. Vanquish High-throughput LC systems are designed to overcome these limitations by providing multiple flow paths for parallelization of specific stages of the LC run.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"><h4>Unique dual technology</h4>The Vanquish platform contains two unique dual modules. Vanquish dual pumps merge two individual, low pressure mixing pumps in one housing enabling separate eluents and gradients for each pump.Vanquish dual split samplers possess two independently controlled injection units including separate injection valves and injection needles. Used in Dual LC and LC-MS workflows only, this enables high throughput and extensive sample characterization workflows.<h3>Two configurations to best serve your needs</h3>Vanquish High-throughput workflows are configured with Thermo Scientific™ Vanquish™ Core system, Thermo Scientific™ Vanquish™ Flex system or Thermo Scientific™ Vanquish™ Horizon system modules. Both workflows make use of two pumps to increase instrument productivity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"><h4>Vanquish Duo UHPLC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li>Sampler: Dual split sampler</li><li>Detector: Two out of the complete detector portfolio</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4>Vanquish Tandem LC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li>Sampler: Split sampler</li><li>Detector: One out of the complete detector portfolio and/or one mass spectrometer</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3>Vanquish Duo UHPLC systems</h3>A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance. The unique Vanquish Duo UHPLC system will:<ul><li>Improve return on investment by reducing cost per sample</li><li>Increase sample throughput without changing validated methods</li><li>Increase capacity without sacrificing bench space</li><li>Accelerate your method development process</li><li>Analyze the same set of samples with multiple methods, reducing sample preparation time and maximizing sample knowledge</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg 245w," sizes="100vw" width="1678" height="512"><h4>What can you do with a Vanquish Duo UHPLC system?</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: What can you do with a Vanquish Duo UHPLC system?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg 245w," sizes="100vw" width="1604" height="658"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two independent assays run simultaneously from a single sample on one LC instrument to deepen your sample knowledge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg 245w," sizes="100vw" width="1372" height="385"><h4>Complete control with just a few clicks</h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a> delivers industry-leading ease-of-use for the Vanquish Duo system. Independently control the two channels of the Vanquish Duo system from a single interface with full traceability of all actions that is 21 CFR Part 11 compliant.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Easy-to-use and intuitive system control of the Dual LC workflow within Chromeleon CDS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg 245w," sizes="100vw" width="1190" height="632"><h3>See the Vanquish Duo UHPLC system</h3>The Vanquish Duo UHPLC system has been built to utilize a wide range of analytical detectors, including mass spectrometry (MS), diode array detection (DAD), charged aerosol detection (CAD), variable wavelength detection (VWD), and fluorescence detection (FLD).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: See the Vanquish Duo UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg 174w," sizes="100vw" width="939" height="841"><h5>1. Vanquish Solvent Monitor</h5>Use the Vanquish Solvent Monitor to increase your regulatory compliance, productivity, and safety of your laboratory. That device guarantees that your HPLC systems will never run dry and the waste will not spill over during your analysis, reducing loss of valuable measurement time and sample material.<h5>2. Vanquish User Interface</h5>With the Vanquish User Interface, you are the master of your LC instrument. The display always shows you the key parameters of your instrument such as flow and pressure and guides you in a visual step-by-step video tutorial through key maintenance tasks.<h5>3. Versatile detection capabilities</h5>Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitate multiple detector methodologies. Vanquish Duo UHPLC systems can be used with any two detectors out of the broad detector portfolio including MS, DAD, VWD, FLD and CAD.<h5>4. Compatible with your software infrastructure</h5>A Vanquish Duo UHPLC system can be operated in various software environments including the latest Chromeleon software feature release, Chromeleon CDS long-term, and extended support version and Waters Empower.<h5>5. Versatile column management</h5>Greater column capacity (two 30 cm columns or a greater number of shorter columns per compartment), plus class-leading temperature range and temperature stability.<h5>6. Delivering powerful separations</h5>Run samples with two similar or different columns to increase throughput or maximize output. Setup with optional second compartment for independent column temperatures.<h5>7. Easier operation</h5>Patented tool-free Thermo Scientific™ Viper™ Fingertight Fittings with near-zero dead volume operation and ergonomic design.<h5>8. Unique Thermo Scientific™ SmartInject technology</h5>Superior retention time precision and enhanced column protection with intelligent SmartInject technology on both flow paths.<h5>9. Two proprietary injection valves</h5>Two separate injection valves with no shared fluidics allowing full application flexibility, including individual eluents, wash liquids and loop sizes.<h5>10. Easier sample handling</h5>Automated barcode reader to eliminate tedious rack configuration.<h5>11. Higher sample capacity</h5>High sample capacity is standard (four plates versus two plates on industry average). Increase capacity further with the optional Thermo Scientific™ Vanquish™ Charger module.<h5>12. Accurate flow for more data confidence</h5>The flow is delivered by a dual pump offering two truly individual devices in a single housing with ternary gradient proportioning.<h5>13. Simple maintenance</h5>Module maintenance is reduced to a minimum and can be worked on without instrument de-stacking, plus smart light bars on the front of the system provide instant system status update.<h5>14. Keep the lab tidy</h5>The built-in drawer stores accessories, related documents, or any other useful material for the system.<h3>Thermo Scientific LC portfolio overview</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660">

Products from Thermo Fisher Scientific - page 2

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