Thermo Scientific Vanquish Charged Aerosol Detectors

Expand your detection range and achieve accurate quantitation in High-Performance Liquid Chromatography (HPLC) with the near-universal Charged Aerosol Detector (CAD). Featuring a wide linear and dynamic range along with a uniform response independent of chemical structure, Thermo Scientific™ Vanquish™ CAD systems allow you to measure virtually all non-volatile and many semi-volatile analytes at low-nanogram to sub-nanogram concentrations. Confidently quantify both trace impurities and highly concentrated active compounds in a single analysis.

Key Benefits

• Standard-free quantitation of unknowns – uniform response enables reliable single-calibrant quantitation
• Superior sensitivity – 10× lower LODs compared to ELSD, LOQs as low as 1–20 ng on-column
• Wide dynamic range – linear up to 2 orders of magnitude, dynamic up to 4 orders
• Compatible with gradient elution – maintain uniform response using inverse gradient, unlike RID
• Integrated diverter valve – prevents contamination, directs unwanted matrix to waste, and improves quantitation of early-eluting compounds
• Compliance and data integrity – full qualification of method parameters, audited flow path control, and seamless integration with Thermo Scientific Chromeleon™ CDS

Thermo Scientific Vanquish Charged Aerosol Detectors

Technical Features

• Detection mode: Records up to 4 unique power values for optimal linear response
• Gas requirements: Nitrogen (recommended) or compressed air
• Dynamic range: Up to 4 orders of magnitude
• Data collection rate: Up to 200 Hz
• Compatibility: Designed for Thermo Scientific™ Vanquish™ HPLC and UHPLC systems; integration with other systems possible
• Outputs: Digital and analog output options available
• Safety features: Overpressure relief, leak sensing, high-temperature shutoff, flood prevention, and diagnostic monitoring

Thermo Scientific Vanquish Charged Aerosol Detectors

Product Portfolio

• Vanquish CAD HP – broad temperature range (ambient, 10–100 °C), versatile high-performance configuration
• Vanquish CAD FP – fixed-point operation at defined set temperatures (ambient, 35 °C, 50 °C, 70 °C)
• Vanquish CAD H – heating-enabled design (ambient +5 to +100 °C)
• Vanquish CAD F – fixed-temperature options (35 °C, 50 °C, 70 °C)
• Vanquish CAD HP, Analog Output – full performance with analog signal output
• Vanquish CAD HP, Digital Output – full performance with digital data output

Thermo Scientific Vanquish Charged Aerosol Detectors