<h3>How long does it actually take to install all the capillaries and fittings on a conventional HPLC system?</h3><h4>The Small Components That Matter Most</h4>When people think about HPLC systems, they often focus on pumps, detectors, columns, or software. Capillaries and fittings are usually seen as minor components because they are relatively inexpensive and physically small. However, every chromatographer eventually discovers that these tiny parts can have a major influence on system performance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Connecting_a_U_HPLC_system_can_be_difficult_at_some_poorly_accessible_locations_3b837b441b.webp" alt="KNAUER: Connecting a (U)HPLC system can be difficult at some poorly accessible locations" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Connecting_a_U_HPLC_system_can_be_difficult_at_some_poorly_accessible_locations_3b837b441b.webp 208w," sizes="100vw" width="720" height="540">Even decades ago, chromatographers recognized the importance of proper connections. In the 1980s, long before UHPLC became common, John Dolan wrote about minimizing dead volume through correct fitting installation. Today, with UHPLC systems operating at extremely high pressures and using columns with very small particle sizes, dead volume is even less tolerable than before. The topic remains just as relevant today as it was back then.Interestingly, despite what many users assume, the chromatographic column itself is often not the primary source of HPLC or UHPLC problems. In my experience, poor connections are far more commonly responsible for issues such as peak broadening, leaks, or loss of efficiency.<h4>The Early Days of HPLC Capillaries</h4>Anyone who has been working with HPLC for many years will probably remember the era of rigid 1/16" stainless steel tubing. Whenever PEEK tubing was unsuitable, stainless steel capillaries were the standard choice.Setting up a system back then was far from convenient. You first had to locate an appropriate length of tubing somewhere in a drawer full of capillaries. Usually, this meant finding a several-meter-long piece and cutting it yourself using a dedicated capillary cutter. After cutting, you needed to ensure the tubing end was smooth and undamaged, hoping that the previous person using the cutter had not accidentally crushed the inner diameter.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Standard_1_16_Capillary_and_needed_tools_and_the_drawer_we_all_know_pretty_well_943d7ed0b2.jpg" alt="KNAUER: Standard 1/16” Capillary and needed tools and the drawer we all know pretty well" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Standard_1_16_Capillary_and_needed_tools_and_the_drawer_we_all_know_pretty_well_943d7ed0b2.jpg 245w," sizes="100vw" width="1277" height="456">Once cut, the tubing often required additional preparation. You might need to deburr the capillary using a grater, shape it carefully with bending tools, and then finally install it using separate fittings and ferrules. And of course, everyone remembers the frustration of dropping a ferrule onto the laboratory floor, where it effectively disappeared forever.At the same time, laboratories often accumulated drawers filled with pre-assembled capillaries that had fixed fittings attached. Reusing these assemblies was risky. If the fitting geometry did not perfectly match the receiving port, users could unintentionally introduce dead volume into the system. The result was often degraded chromatographic performance, broad peaks, and frustrating troubleshooting sessions involving the entire laboratory team. In worse cases, excessive force could damage threads or receiving ports while attempting to stop leaks.During that period, assembling and connecting a complete HPLC system could easily consume half a day of work.<h4>The Improvement: Flexible and Pre-Cut Capillaries</h4>Later, laboratories gradually adopted pre-cut tubing and flexible capillaries, which represented a significant improvement over manually preparing stainless steel tubing.With these newer capillaries, users simply selected the correct length and installed the tubing directly. Flexible capillaries adapted naturally to the required shape, eliminating much of the manual bending and shaping work. Installation became faster, easier, and far less stressful.Still, these systems had limitations. Although the capillary itself improved, the fitting technology remained largely unchanged. Many of these capillaries were still effectively single-use components. If a connection was installed incorrectly because the tubing was not fully inserted into the receiving port before tightening, the result was often another unusable capillary destined for the growing “capillary drawer.” Sustainability was certainly not a strong point of these systems.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_A_typical_capillary_drawer_It_was_tricky_to_open_and_close_it_sometimes_530dd2087c.webp" alt="KNAUER: A typical capillary drawer. It was tricky to open and close it sometimes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_A_typical_capillary_drawer_It_was_tricky_to_open_and_close_it_sometimes_530dd2087c.webp 208w," sizes="100vw" width="1024" height="768">Even with these advancements, system setup still required considerable time and effort.<h4>The Real Breakthrough: Modern Tool-Free Connection Systems</h4>A major breakthrough finally arrived when manufacturers introduced a completely redesigned fitting and capillary concept aimed specifically at simplifying UHPLC connections.These newer systems came with fittings pre-installed directly on the capillary. Unlike traditional ferrule-based systems, the fittings automatically adjusted to different port depths and sealed directly at the bottom of the port. This dramatically reduced the amount of torque required and eliminated the need for complicated installation techniques.Perhaps the biggest advantage was convenience. These capillaries could be connected and disconnected more than 100 times without tools, while remaining entirely finger-tight. And best of all, ferrules no longer disappeared onto the laboratory floor.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_The_little_things_that_do_the_click_3a0469d516.jpg" alt="KNAUER: The little things that do the “click”" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_The_little_things_that_do_the_click_3a0469d516.jpg 245w," sizes="100vw" width="1866" height="1022">The system I currently use includes an especially useful feature: a patented torque-limiting mechanism that prevents both under-tightening and over-tightening. Once the correct torque is reached, the fitting produces a tactile “click,” providing immediate feedback that the connection is secure and properly installed every time.<h4>From Half a Day to Fifteen Minutes</h4>Thanks to these modern connection systems and pre-configured startup kits, installing an HPLC or UHPLC system today is dramatically faster than it used to be.What once consumed hours of work can now be completed in less than 15 minutes. The improvements in usability, reproducibility, and sustainability over recent years have been remarkable.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_e62b80154b.webp" alt="KNAUER: Trouble-free connection systom for HPLC and UHPLC" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_e62b80154b.webp 221w," sizes="100vw" width="690" height="487"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_2_71c24acdf5.webp" alt="KNAUER: Trouble-free connection systom for HPLC and UHPLC" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_2_71c24acdf5.webp 224w," sizes="100vw" width="1920" height="1339">And while today’s solutions already represent a huge leap forward, the evolution of HPLC connection technology is certainly not over yet. Looking ahead, it will be exciting to see how future innovations continue to simplify chromatography workflows even further.<blockquote>If you want to learn more about KNAUER´s capillaries, fittings and (U)HPLC system start-up kits and are interested in details and numbers, I highly recommend our brand <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/r75ev6rjivdbid246k60zrs3gjpvwdi5b8em_fad0f92fd9.pdf">new tech note "Benefits of KNAUER´s trouble-free analytical capillaries in terms of HPLC and UHPLC system performance</a>" and a visit to our <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2402">products online</a>.</blockquote>

Let´s Connect a whole (U)HPLC system without tools and trouble

News from LabRulezLCMS Library - Week 21, 2026

If you’ve reviewed your laboratory’s operational budget recently, you have likely noticed a troubling trend: the cost of keeping your instruments running is climbing, and nitrogen gas is a major culprit.According to Organomation’s newly released <a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/nitrogen-usage-survey-2025-download">Nitrogen Usage 2025 Survey Report</a>, you are not alone in this frustration. In fact, 35% of laboratories ranked high costs as their number one frustration with their current nitrogen supply — overshadowing safety, logistics, and maintenance concerns.With 96% of labs expecting their nitrogen demand to increase or remain steady over the next three years, waiting for prices to drop isn’t a viable strategy. To protect your budget, you need to understand why prices are surging and, more importantly, how to insulate your lab from the volatility.<h3>The "Perfect Storm" Driving Prices Up</h3>As a chemist, you know that nitrogen is abundant in the atmosphere. However, the industrial process of separating, purifying, compressing, and transporting it is energy-intensive and tied heavily to global markets. Three key factors are driving the 2025 price surge:<h4>1. Rising Energy Costs</h4>While nitrogen itself is free, the energy required to produce high-purity nitrogen gas (via fractional distillation) is not. Industrial gas manufacturing is heavily reliant on energy prices. In 2025, U.S. natural gas prices for industrial sectors have seen significant volatility, with some forecasts showing double-digit percentage increases for power plants due to export demands and tightening domestic supply. When the cost of energy rises,<a target="_blank" rel="noopener noreferrer" href="https://www.reuters.com/markets/commodities/energy/high-rising-natural-gas-costs-may-spur-fresh-climb-us-coal-use-2025-12-03/"> gas suppliers pass those costs directly to the consumer</a>.<h4>2. The Logistics Premium</h4>If you rely on high-pressure cylinders or liquid dewars, you aren't just paying for gas; you are paying for diesel, driver wages, and truck maintenance. Logistics frustrations were a top complaint in our 2025 survey, particularly for labs using liquid dewars.<ul><li>Delivery Fees &amp; Surcharges: Fuel surcharges are now a standard line item on many invoices, fluctuating weekly with the oil market.</li><li>Cylinder Rental: The "rent" for holding steel cylinders often creeps up annually, regardless of how much gas you actually consume.</li></ul><h4>3. Hidden Waste (The "Boil-Off" Tax)</h4>For labs using liquid nitrogen dewars, the "price per liter" is deceptive. Liquid nitrogen constantly boils off to maintain its temperature. If your lab uses dewars for gaseous applications (like evaporation), you are paying for gas that vanishes into the room before it ever reaches your instrument. Our survey found that while dewars nominally cost $2.06/liter, the effective cost is often higher due to this inevitable waste.<h3>The Data: Cylinders vs. Generators</h3>The most striking finding from our 2025 Survey Report was the massive price disparity between supply methods. When we analyzed the average cost per liter across 78 laboratories, the data was clear:<h5>Nitrogen Source: Average Cost Per Liter</h5><ul><li>Gas Cylinders: $2.79</li><li>Liquid Dewars: $2.06</li><li>Lab-Scale Generator: $0.70</li></ul>Laboratories relying on cylinders are paying nearly 400% more per liter than those generating their own gas. Over the course of a year, this difference can amount to thousands of dollars in operational waste.<h3>How to Reduce the Price Tag: A Two-Step Strategy</h3>You cannot control the global energy market or supply chain logistics. However, you can control how you source and use your nitrogen.<h4>Step 1: Cut the Cord (Switch to Generation)</h4>The single most effective way to lower your nitrogen spend is to stop buying it in tanks. While the upfront cost of equipment can sometimes be a hurdle for capital budgets, new financial models are making this transition accessible for labs of all sizes.<h5>Why Generation Wins on Cost</h5>A nitrogen generator, like the Organomation NITRO-GEN, separates nitrogen from your lab's existing compressed air supply using a hollow-fiber membrane. Once installed, your "cost per liter" drops to essentially zero—you are only paying for the electricity to run the compressor.<ul><li>Rapid ROI: Most labs see a return on investment in 12 to 18 months by<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/how-much-could-i-save-switching-to-a-nitrogen-generator"> generating nitrogen</a>. After this break-even point, your nitrogen supply becomes a fixed asset rather than a monthly liability.</li><li>Operational Freedom: Weighing under 20 lbs and wall-mountable, the NITRO-GEN <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1902">N2 generator</a> produces up to 20 L/min of gas, sufficient to support blowdown evaporators with up to 48 sample positions.</li></ul><h5>Overcoming the "Sticker Shock" with Lease-to-Own</h5>Historically, the barrier to entry for nitrogen generators has been the initial purchase price. To solve this, Organomation has introduced a Lease-to-Own program designed to align equipment costs with your operating budget rather than your capital reserves.This program transforms a large capital expenditure into a manageable monthly operating expense. Unlike standard rental agreements where payments are lost forever, this program allows you to build equity.<ul><li>Immediate Savings: You can install the unit and stop paying cylinder rental fees immediately, often letting the operational savings offset the lease payments.</li><li>Path to Ownership: At the end of the lease term, you own the equipment outright—often for a nominal final payment (as low as $1).</li><li>Preserve Capital: By spreading the cost over time, you keep your cash reserves available for other critical research needs or staffing.</li></ul>By leveraging a lease-to-own model, you can "cut the cord" on gas contracts today without waiting for next year’s capital budget approval.<h4>Step 2: Optimize Your Usage (Stop Wasting Gas)</h4>Even with a cheap supply, wasting gas is bad science and bad business. especially if you use nitrogen for sample concentration (blowdown evaporation).<ul><li>Use Individual Flow Control: Many basic evaporators blow gas into every position, regardless of whether a sample is present. High-quality units (like the<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products?category=3&amp;manufacturerItems=540&amp;search=N-EVAP"> N-EVAP</a>) feature individual needle valves for each sample position. Rule of thumb: If you are running 10 samples in a 24-position unit, ensure the other 14 needles are closed.</li><li>Check for Leaks: It sounds basic, but a loose fitting on a regulator can waste cylinders of gas over a weekend. A simple "snoop test" (soapy water) on your connections every quarter is a zero-cost maintenance habit that saves money.</li><li>Optimize Bath Temperature: In nitrogen blowdown evaporation, gas flow and temperature work together. If your water bath is too cool, you have to blow gas for longer to <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/optimum-temperature-for-nitrogen-evaporation-instruments">achieve dryness</a>. Ensuring your bath is at the optimal temperature for your solvent (e.g., 35-40°C for DCM) reduces the total time the gas needs to run.</li></ul><h3>Conclusion</h3>The era of "cheap" delivered gas is likely behind us. As the 2025 survey data shows, labs sticking to the status quo of cylinders and dewars are facing rising costs and logistical headaches. By transitioning to on-demand generation and optimizing your evaporation workflows, you can insulate your lab from market volatility and keep your budget focused on research, not utility bills.<blockquote>Want to see the full data? Download the<a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/nitrogen-usage-survey-2025-download"> Laboratory Nitrogen Usage Report </a>to benchmark your lab’s spending against industry peers.Curious about your potential savings? Try our <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/how-much-could-i-save-switching-to-a-nitrogen-generator">Nitrogen Generator Savings Calculator </a>to see exactly how much you could save by making the switch.</blockquote>

Why Nitrogen Is Costing Labs More Than Ever — And How to Reduce the High Price Tag

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

ECOM ECP201L Preparative HPLC Pump

Preparative HPLC pump with a flow rate range of up to 1000 ml/min.

<div style="display:block;" aria-labelledby="tab_item-0">The ECP201L Preparative Pump is an innovative, powerful, and cost-effective unit for preparative liquid chromatography where high pressure is needed.&nbsp;The pump with 4 low-pressure valves delivers a flow rate of up to 1000 ml/min at a very&nbsp;high output pressure of up to 15 MPa (2176 psi).<h3>Main features and benefits</h3><ul><li>Durability&nbsp;– The pump is constructed for high pressure and flow rates. This makes it suitable for day-to-day long-term use in production</li><li>Wide application possibilities – The unit is used for pharmaceutical separations and plant extract purification, such as cannabinoids, peptides, and oligonucleotides. Also, it has much wider use in other chemical production, such as dosing into chemical reactors, and in various laboratory uses. Another advantage is the usability of the same device for separation method development.</li><li>Smart controls and diagnostics&nbsp;– It is easy to operate, especially with ECOMAC and Clarity software. This makes unit management powerful and convenient. The basic version of the ECOMAC software is available free of charge. It is also used for service and diagnostics.</li><li>Other useful features<ul style="list-style-type:circle;"><li>A new learning algorithm for pulsation suppression</li><li>A leakage sensor</li><li>A seal wash kit for longer piston seal life</li><li>Also available in configurations made of&nbsp;certified bio-inert materials</li></ul></li></ul><h4>Parameters</h4><ul><li>Flow rate: 1– 1000 ml/min</li><li>Maximum operating pressure: 15 MPa up to 1000 ml/min</li><li>Flow rate setting: 1 ml/min steps</li><li>Repeatability of flow rate adjusting:&nbsp;± 1 %</li><li>Accuracy of flow rate setting:&nbsp;± 2 %</li><li>Wetted materials:&nbsp;stainless steel, PEEK, TefzelTM, PE, ceramic, seals</li><li>Communication:&nbsp;RS232,Ethernet (LAN),USB,Remote digital I/O</li><li>Power supply:&nbsp;100-240V VAC</li><li>Power input: 500 VA</li><li>Dimensions W x H x D:&nbsp;276 x 153 x 620 mm (10.87 x 6.14 x 24.40 in)</li><li>Weight:&nbsp;26 kg (57.32 lb)</li><li>Pressure Compensation Learning:&nbsp;yes&nbsp;</li></ul></div>

ECOM PREPBOX A3L8E Chromatography Separation System

PREPBOX is a compact alternative to modular preparative systems. It is assembled according to the customer's wishes.

<div style="display:block;" aria-labelledby="tab_item-0">Complete preparative modular system with one basic gradient pump and optionally secondary pump for repetitive sampling or with injection valve. Also switching valve for&nbsp;<abbr title="Countercurrent Chromatography">CCC</abbr> applications. PDA four channel detector up to 800&nbsp;nm.&nbsp;It is assembled according to the customer's wishes. It is used for high-capacity systems or with centrifugal chromatography systems like in pharmaceutical purification of cannabis extracts (<abbr title="Cannabidiol">CBD</abbr>, <abbr title="Cannabinol">CBN</abbr>, <abbr title="Cannabigerol">CBG</abbr>, <abbr title="Cannabichromene">CBC</abbr>, <abbr title="Tetrahydrocannabinol">THC</abbr>...).ECOMAC SW installed at internal PC controls the system. Fractions are collected by means of&nbsp;10 position valve&nbsp; It is necessary to purchase an operating system for the PREPBOX&nbsp;- in most cases we recommend Windows OS&nbsp;(P/N:&nbsp;ABB90000) or Linux&nbsp;(on request). The system also supports the Clarity software. It is also possible to purchase a wireless mouse and keyboard set&nbsp;(P/N:&nbsp;EPC-0028) and a computer monitor&nbsp;(P/N:&nbsp;EPC-0027).<h5>TOY18DAD 800L Detector</h5>It is UV-VIS diode array detector, which allow measuring absorbance of four wavelengths in range of 200-800&nbsp;nm simultaneously in one cell just as scanning of whole spectra.<h5>ECP201L Preparative HPLC Pump</h5>Preparative pump suited for preparative liquid chromatography with very high pressure up to 15&nbsp;MPa&nbsp;at flow rate of 1000&nbsp;ml/min. Advantage of this pump is a very stable run even at low flow rates.<h5>ECP2300 Preparative Gradient Pump</h5>Preparative HPLC pump suited for&nbsp;preparative&nbsp;applications in liquid chromatography with a pressure up to 15 MPa at flow rate of 300&nbsp;ml/min.&nbsp;New sophisticated unit allows achieving a precise&nbsp;low-pressure gradient, i.e. gradual changes of solvent composition by mixing&nbsp;up to four liquids&nbsp;at the pump entry.<h3>Parameters</h3><ul><li>Interface: 5x USB, HDMI, 2X RS232, LAN, VGA</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 490 W</li><li>Dimensions W x H x D: 405x490x525 mm (15.94x19.29x20.67 in)</li><li>Weight: 55 kg</li></ul></div>

ECOM COMPACT SEMI-PREPARATIVE SYSTEM (10 ml/min, ECS08)

A highly effective Compact semi-preparative system containing UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector.

A highly effective Compact semi-preparative system containing&nbsp;UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector. The detector allows absorbance measuring at four wavelengths at the same time or scanning through entire spectrum.The system is controlled by a built-in PC and touchscreen.A modular solution allows configuring the unit according to customer needs. This system contains a detector with a wavelength range of 200 –&nbsp; 800 nm, a pump with a flow rate up to 10 ml/min and a fraction collector.<h3>Main parts</h3><h5>TOY18DAD800L DETECTOR</h5>It is a UV-VIS diode array detector, which allows measuring the absorbance of&nbsp;four wavelengths in a range of 200–800 nm simultaneously in one cell&nbsp;just as scanning of whole spectra. Standardly is assembled with preparative cell PLCC07L, but other cells are available.<h5>ECF2096 FRACTION COLLECTOR</h5>Fractions are collected according to chosen method, which is simply created using a touch screen. Racks for 8, 21,40 ml tubes, 60 ml vials or 12 funnels, 30 mm.<h5>AUTOMATIC INJECT VALVE</h5>The valve is driven by a step motor and it is automatically switched by software. The system also allows manual sample injection by opening the column.<h5>SYSTEM PC INFO</h5>Installed industrial PC with Intel Atom 4 core processor. OS Linux, Touch screen 12,1“ 1024 x 786, SW QUEEN controls: gradient, flow rate, wavelengths, fractions collection etc. Remote administration is available. Possibility of measuring at four wavelengths at the same time or scanning through entire spectra. Furthermore, the possibility of displaying 3D data.&nbsp;<h5>ECP2010 ANALYTICAL GRADIENT PUMP</h5>Modified for the compact system,&nbsp;analytical gradient pump with degasser&nbsp;and with flow rate up to 10 ml/min&nbsp;(40 MPa, 5082 PSI).&nbsp;Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions. Four gradient valves allow changing mobile phases without bottles alternation.&nbsp;<h3>COMPACT PREPARATIVE SYSTEM &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</h3><ul><li>Interface: 3xUSB, 2xLAN, RS232</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 400 W</li><li>Dimensions (W x H x D): 500 x 678 x 482 mm (19.69 x 26.69 x 18.98")</li><li>Weight: 55 kg (121.30 lb)</li></ul><h5>Detector</h5><ul><li>Wavelength range: 200 - 800 nm &nbsp; (256 elements on CCD)</li><li>Number of channels (Signals): 4</li><li>Scan: 200 - 800 nm,up to &nbsp;20 Hz, step 1 nm</li><li>Typical spectral half-width: 10 mn</li><li>Accuracy of adjustment / Reproducibility: ± 1 nm / ±0.5 nm</li><li>Noise level at test cell (254 nm, TC 0.75s): ± 5 x 10-5 AU</li><li>Drift at test cell (254 nm after 1 h): 1 x 10-3 AU/hr</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK</li><li>Time constant (T63): 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1 s</li></ul><h5>Fraction collector</h5><ul><li>Available racks (two racks per unit)<ul><li>EC08 48 tubes of 8 ml</li><li>EC21 36 tubes of 21 ml</li><li>EC40 24 tubes of 40 ml</li><li>EC60 20 vials of 60 ml</li><li>F12A 12 funnels, 30 mm</li></ul></li><li>Maximum flow rate for tubes 8 ml: max. 50 ml/min</li><li>Maximum flow rate for tubes 21, 40 ml: max. 300 ml/min</li><li>Maximum flow rate for vials 60 ml: max. 300 ml/min</li><li>Maximum flow rate for funnels: max. 500 ml/min</li><li>Wetted materials: FEP, Tefzel®, PPS, KEL-F, PTFE, PEEK, SS 316, SIMAX glass</li><li>Input tubing: OD 1/8“ x ID 1/16“ FEP</li></ul><h5>Pump</h5><ul><li>Flow rate: 0.02 - 10.00 ml/min</li><li>Maximum operating pressure: 40 MPa (5082 PSI)</li><li>Repeatability of flow rate adjusting: ± 0.5 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials: stainless steel, sapphire, KEL-F, seals*</li><li>Output capillary outer diameter: 1/16”</li><li>Input tubing outer diameter: 1/8”</li><li>Gradient valves control module - OPTIONALLY: Up to four valves</li></ul>

ECOM COMPACT PREPARATIVE SYSTEM (50 ml/min, ECS58)

A highly effective Compact preparative system containing UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector.

A highly effective Compact preparative system containing&nbsp;UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector. The detector allows absorbance measuring at four wavelengths at the same time or scanning through entire spectrum.The system is controlled by a built-in PC and touchscreen.A modular solution allows configuring the unit according to customer needs. This system contains a detector with a wavelength range of 200 –&nbsp; 800 nm, a pump with a flow rate up to 10 ml/min and a fraction collector.<h3>Main parts</h3><h5>TOY18DAD800L DETECTOR</h5>It is a UV-VIS diode array detector, which allows measuring the absorbance of&nbsp;four wavelengths in a range of 200–800 nm simultaneously in one cell&nbsp;just as scanning of whole spectra. Standardly is assembled with preparative cell PLCC07L, but other cells are available.<h5>ECF2096 FRACTION COLLECTOR</h5>Fractions are collected according to chosen method, which is simply created using a touch screen. Racks for 8, 21,40 ml tubes, 60 ml vials or 12 funnels, 30 mm.<h5>AUTOMATIC INJECT VALVE</h5>The valve is driven by a step motor and it is automatically switched by software. The system also allows manual sample injection by opening the column.<h5>SYSTEM PC INFO</h5>Installed industrial PC with Intel Atom 4 core processor. OS Linux, Touch screen 12,1“ 1024 x 786, SW QUEEN controls: gradient, flow rate, wavelengths, fractions collection etc. Remote administration is available. Possibility of measuring at four wavelengths at the same time or scanning through entire spectra. Furthermore, the possibility of displaying 3D data.&nbsp;<h5>ECP2050 PREPARATIVE GRADIENT PUMP</h5>Modified for the compact system,&nbsp;quaternary gradient pumps&nbsp;with flow rate up to&nbsp;50 ml/min&nbsp;(30 MPa, 4351 PSI).&nbsp;Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.<h3>COMPACT PREPARATIVE SYSTEM &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</h3><ul><li>Interface: 3xUSB, 2xLAN, RS232</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 400 W</li><li>Dimensions (W x H x D): 500 x 678 x 482 mm (19.69 x 26.69 x 18.98")</li><li>Weight: 55 kg (121.30 lb)</li></ul><h5>Detector</h5><ul><li>Wavelength range: 200 - 800 nm &nbsp; (256 elements on CCD)</li><li>Number of channels (Signals): 4</li><li>Scan: 200 - 800 nm,up to &nbsp;20 Hz, step 1 nm</li><li>Typical spectral half-width: 10 mn</li><li>Accuracy of adjustment / Reproducibility: ± 1 nm / ±0.5 nm</li><li>Noise level at test cell (254 nm, TC 0.75s): ± 5 x 10-5 AU</li><li>Drift at test cell (254 nm after 1 h): 1 x 10-3 AU/hr</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK</li><li>Time constant (T63): 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1 s</li></ul><h5>Fraction collector</h5><ul><li>Available racks (two racks per unit)<ul><li>EC08 48 tubes of 8 ml</li><li>EC21 36 tubes of 21 ml</li><li>EC40 24 tubes of 40 ml</li><li>EC60 20 vials of 60 ml</li><li>F12A 12 funnels, 30 mm</li></ul></li><li>Maximum flow rate for tubes 8 ml: max. 50 ml/min</li><li>Maximum flow rate for tubes 21, 40 ml: max. 300 ml/min</li><li>Maximum flow rate for vials 60 ml: max. 300 ml/min</li><li>Maximum flow rate for funnels: max. 500 ml/min</li><li>Wetted materials: FEP, Tefzel®, PPS, KEL-F, PTFE, PEEK, SS 316, SIMAX glass</li><li>Input tubing: OD 1/8“ x ID 1/16“ FEP</li></ul><h5>Pump</h5><ul><li>Flow rate: 0.1 – 50 ml/min</li><li>Maximum operating pressure: 30 MPa (4351 PSI)</li><li>Flow rate setting: 0.1 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 0.5 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials: stainless steel, PEEK, TefzelTM, PE, ceramic, seals *</li><li>Output capillary outer diameter: 1/8”</li><li>Input tubing outer diameter: 1/8”</li><li>Gradient valves control module - OPTIONALLY: Up to six valves</li></ul>

ECOM COMPACT PREPARATIVE SYSTEM (250 ml/min, ECS28)

A highly effective Compact preparative system containing UV-VIS DAD detector, preparative gradient pump, an automatic inject valve, and a fraction collector. 

A highly effective Compact semi-preparative system containing&nbsp;UV-VIS DAD detector, preparative gradient pump, an automatic inject valve, and a fraction collector. The detector allows absorbance measuring at four wavelengths at the same time or scanning through entire spectrum.The system is controlled by a built-in PC and touchscreen.A modular solution allows configuring the unit according to customer needs. This system contains a detector with a wavelength range of 200 –&nbsp; 800 nm, a pump with a flow rate up to 10 ml/min and a fraction collector.<h3>Main parts</h3><h5>TOY18DAD800L DETECTOR</h5>It is a UV-VIS diode array detector, which allows measuring the absorbance of&nbsp;four wavelengths in a range of 200–800 nm simultaneously in one cell&nbsp;just as scanning of whole spectra. Standardly is assembled with preparative cell PLCC07L, but other cells are available.<h5>ECF2096 FRACTION COLLECTOR</h5>Fractions are collected according to chosen method, which is simply created using a touch screen. Racks for 8, 21,40 ml tubes, 60 ml vials or 12 funnels, 30 mm.<h5>AUTOMATIC INJECT VALVE</h5>The valve is driven by a step motor and it is automatically switched by software. The system also allows manual sample injection by opening the column.<h5>SYSTEM PC INFO</h5>Installed industrial PC with Intel Atom 4 core processor. OS Linux, Touch screen 12,1“ 1024 x 786, SW QUEEN controls: gradient, flow rate, wavelengths, fractions collection etc. Remote administration is available. Possibility of measuring at four wavelengths at the same time or scanning through entire spectra. Furthermore, the possibility of displaying 3D data.&nbsp;<h5>ECP2200 PREPARATIVE GRADIENT PUMP</h5>Modified for the compact system,&nbsp;quaternary gradient pumps&nbsp;with flow rate up to&nbsp;250 ml/min&nbsp;(30 MPa at 100 ml/min and then linearly down up to 15 MPa at 250 ml/min).&nbsp;Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.<h3>COMPACT PREPARATIVE SYSTEM &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</h3><ul><li>Interface: 3xUSB, 2xLAN, RS232</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 400 W</li><li>Dimensions (W x H x D): 500 x 678 x 482 mm (19.69 x 26.69 x 18.98")</li><li>Weight: 55 kg (121.30 lb)</li></ul><h5>Detector</h5><ul><li>Wavelength range: 200 - 800 nm (256 elements on CCD)</li><li>Number of channels (Signals): 4</li><li>Scan: 200 - 800 nm,up to &nbsp;20 Hz, step 1 nm</li><li>Typical spectral half-width: 10 mn</li><li>Accuracy of adjustment / Reproducibility: ± 1 nm / ±0.5 nm</li><li>Noise level at test cell (254 nm, TC 0.75s): ± 5 x 10-5 AU</li><li>Drift at test cell (254 nm after 1 h): 1 x 10-3 AU/hr</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK</li><li>Time constant (T63): 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1 s</li></ul><h5>Fraction collector</h5><ul><li>Available racks (two racks per unit)<ul><li>EC08 48 tubes of 8 ml</li><li>EC21 36 tubes of 21 ml</li><li>EC40 24 tubes of 40 ml</li><li>EC60 20 vials of 60 ml</li><li>F12A 12 funnels, 30 mm</li></ul></li><li>Maximum flow rate for tubes 8 ml: max. 50 ml/min</li><li>Maximum flow rate for tubes 21, 40 ml: max. 300 ml/min</li><li>Maximum flow rate for vials 60 ml: max. 300 ml/min</li><li>Maximum flow rate for funnels: max. 500 ml/min</li><li>Wetted materials: FEP, Tefzel®, PPS, KEL-F, PTFE, PEEK, SS 316, SIMAX glass</li><li>Input tubing: OD 1/8“ x ID 1/16“ FEP</li></ul><h5>Pump</h5><ul><li>Flow rate: 0.5 – 250 ml/min</li><li>Maximum operating pressure: 30 MPa (4351 PSI) up to 100 ml/min then &nbsp;linearly down up to</li><li>Flow rate setting: 0.1 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 1 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials: stainless steel, PEEK, TefzelTM, PE, ceramic, seals *</li><li>Output capillary outer diameter: 1/8”</li><li>Input tubing outer diameter: 1/8”</li><li>Gradient valves control module - OPTIONALLY: Up to six valves</li></ul>

<div style="display:block;" aria-labelledby="tab_item-0">Complete preparative modular system with one basic gradient pump and optionally secondary pump for repetitive sampling or with injection valve. Also switching valve for&nbsp;<abbr title="Countercurrent Chromatography">CCC</abbr> applications. PDA four channel detector up to 800&nbsp;nm.&nbsp;It is assembled according to the customer's wishes. It is used for high-capacity systems or with centrifugal chromatography systems like in pharmaceutical purification of cannabis extracts (<abbr title="Cannabidiol">CBD</abbr>, <abbr title="Cannabinol">CBN</abbr>, <abbr title="Cannabigerol">CBG</abbr>, <abbr title="Cannabichromene">CBC</abbr>, <abbr title="Tetrahydrocannabinol">THC</abbr>...).ECOMAC SW installed at internal PC controls the system. Fractions are collected by means of&nbsp;10 position valve&nbsp; It is necessary to purchase an operating system for the PREPBOX&nbsp;- in most cases we recommend Windows OS&nbsp;(P/N:&nbsp;ABB90000) or Linux&nbsp;(on request). The system also supports the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity software</a>. It is also possible to purchase a wireless mouse and keyboard set&nbsp;(P/N:&nbsp;EPC-0028) and a computer monitor&nbsp;(P/N:&nbsp;EPC-0027).<h5>TOY18DAD 800L Detector</h5>It is UV-VIS diode array detector, which allow measuring absorbance of four wavelengths in range of 200-800&nbsp;nm simultaneously in one cell just as scanning of whole spectra.<h5>ECP2300 Preparative Gradient Pump</h5>Two peparative HPLC pump suited for&nbsp;preparative&nbsp;applications in liquid chromatography with a pressure up to 15 MPa at flow rate of 300&nbsp;ml/min.&nbsp;New sophisticated unit allows achieving a precise&nbsp;low-pressure gradient, i.e. gradual changes of solvent composition by mixing&nbsp;up to four liquids&nbsp;at the pump entry.<h4>Complete preparative modular system with:</h4><ul><li>one basic gradient pump</li><li>for sampling secondary pump or injection valve</li><li>optionally switching valve for CCC</li><li>PDA detector up to 800 nm</li><li>10 positions valve for fractions collecting</li><li>PC board with ECOMAC SW</li></ul><h3>Parameters</h3><ul><li>Interface: 5x USB, HDMI, 2X RS232, LAN, VGA</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 4900 W</li><li>Dimensions W x H x D: 405x490x525 mm (15.94x19.29x20.67 in)</li><li>Weight: 50 kg</li></ul></div>

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