The human body is the most sophisticated atomic engineer. This idea underpins a breakthrough technology developed by an international research team led by scientists from the Czech Advanced Technology and Research Institute (CATRIN) at Palacký University Olomouc and the Centre for Energy and Environmental Technologies (CEET) at VSB – Technical University of Ostrava. By drawing inspiration from the way enzymes function in the human body, the researchers have created a novel material that could fundamentally change the industrial production of hydrogen peroxide and other important chemicals. The new approach simplifies the production process, eliminates the need for toxic organic solvents and expensive precious metals, and requires only sunlight, oxygen and water to operate. The results <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-025-67189-3">were published by the prestigious journal Nature Communications</a>, which ranked the study among the 50 most significant scientific discoveries of the year.Hydrogen peroxide is one of the most important industrial chemicals. It is widely used not only in the chemical industry but also in pharmaceuticals, medicine, the textile industry and water-treatment technologies. The global hydrogen peroxide market is estimated to exceed USD 5 billion annually. Conventional production involves a multistep process that relies on toxic organic solvents and costly palladium-based catalysts. In addition, both the starting chemicals and the resulting waste products can have negative impacts on human health and the environment.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Cesti_vedci_vyvinuli_material_pro_vyrobu_chemikalii_z_vody_a_slunce_Inspirovali_se_lidskymi_enzymy_2_c4d5ecbafb.webp" alt="CATRIN: Czech scientists develop a material for producing chemicals from water and sunlight, inspired by human enzymes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Cesti_vedci_vyvinuli_material_pro_vyrobu_chemikalii_z_vody_a_slunce_Inspirovali_se_lidskymi_enzymy_2_c4d5ecbafb.webp 208w," sizes="100vw" width="1600" height="1200">“Our aim was to develop a material that enables the efficient, environmentally friendly and affordable production of hydrogen peroxide. When designing this photocatalyst, we were inspired by the structure and behaviour of enzymes in the human body. The result is a technology that does not require toxic organic solvents or expensive precious metals and instead uses a low-cost material based on carbon, nitrogen and copper. It operates in water using only sunlight and oxygen from the air,” said Radek Zbořil, leader of research teams at CATRIN and CEET.In developing the new photocatalyst, the Czech scientists mimicked the function of cytochrome c oxidase—an enzyme that enables human cells to obtain energy by transferring electrons to oxygen. This process relies on copper atoms embedded in the enzyme’s structure, and it was precisely this mechanism that the researchers sought to reproduce.“We very precisely replicated the chemical environment of metals within the enzyme’s structure and anchored copper atoms onto the surface of extremely small carbon nanoparticles with photocatalytic properties. When exposed to light, highly efficient electron transfer occurs between the carbon nanoparticles, the copper atoms and oxygen molecules. This process closely resembles an enzymatic reaction and enables high hydrogen peroxide production,” explained the first author of the study, Lukáš Zdražil, who is affiliated with both CATRIN and CEET.Producing hydrogen peroxide using sunlight and water has been a long-standing goal of research teams worldwide, as it eliminates the use of toxic organic solvents and avoids the formation of hazardous by-products. Until now, however, research in this area has largely remained at an academic level, mainly due to the use of noble metals and often complex photocatalyst designs. Laboratory studies have also resulted in relatively low hydrogen peroxide yields, which could not compete with existing industrial processes.“The new photocatalyst achieves hydrogen peroxide production rates up to two orders of magnitude higher than all previously reported systems, bringing us much closer to industrial requirements. In addition, the material is completely non-toxic, easily recyclable and reusable,” added Zdražil.The Czech teams are now focusing on potential applications of this technology in decentralised production units. Such systems could enable efficient, local production of hydrogen peroxide, for example for use in agriculture, pharmaceutical manufacturing or environmental applications. The combination of solar energy and materials inspired by enzymatic systems may also lead to further promising advances.“I believe that mimicking the structures and functions of iron- and copper-based enzymes could pave the way for other innovative technologies in the chemical industry and pharmaceuticals, such as the production of epoxides, alcohols or phenols,” concluded Zbořil.

 Czech scientists develop a material for producing chemicals from water and sunlight, inspired by human enzymes

<h4>"Education is central to how I approach research"</h4>Analytical scientist Dr Bob Pirok of the Van ‘t Hoff Institute for Molecular Sciences has been awarded the 19th annual ‘Emerging Leader in Chromatography Award’ by LCGC International, a well-known global publisher in the field of separation science. Pirok will receive the award at the upcoming Pittcon 2026 conference held 7-11 March in San Antonio, Texas.With the Emerging Leader in Chromatography Award, LGCG International recognises the achievements and aspirations of talented early-career separation scientists who have made strides toward the advancement and applications of chromatography techniques. Pirok is honoured for his work in the development of comprehensive two-dimensional liquid chromatography (LC×LC), automated method development, and chemometric data analysis.Already in his early career, Pirok has emerged as a prominent figure in addressing long-standing challenges in LC×LC, which include method complexity, data interpretation, and experimental optimisation. His research is characterised by close interaction between theory, instrumentation, and application, as well as sustained collaboration with academic and industrial partners. On a mission to transform advanced chromatographic techniques into practical and robust analytical tools, Pirok has authored or co-authored more than 50 peer-reviewed publications and established an internationally visible research program at the interface of separation science, statistics, and artificial intelligence. All this within a few years of receiving his PhD in 2019.<h4>Automated method development</h4>Central to Pirok’s research is the novel modular AutoLC platform, which enables prototype automated method development. With a capacity to run unsupervised (i.e. without human input), it is able to tackle samples of unknown composition by autonomous analysis of (2D-)LC(-MS) data. It is flexible, able to support different optimization strategies and capable of integrating tools developed by scientists in the global chromatographic community.Accessibility and sustainability are key motivations behind AutoLC, says Pirok: “State-of-the-art separation technology is often overly sophisticated. We aim to make it more robust, automated, and usable beyond a small group of specialists, as efficiently as possible. By providing more detailed and reliable molecular information, such technologies can better inform molecular design and accelerate the development of new materials and applications.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HIMS_From_left_to_right_Bob_Pirok_Prof_Peter_Schoenmakers_Ph_D_candidate_Gerben_van_Henten_and_postdoc_researcher_Tijmen_Bos_in_the_Auto_LC_lab_at_the_Van_t_Hoff_Institute_for_Molecular_Sciences_a4fe9bc6f7.jpg" alt="HIMS: From left to right: Bob Pirok, Prof. Peter Schoenmakers, PhD candidate Gerben van Henten, and postdoc researcher Tijmen Bos in the AutoLC lab at the Van ‘t Hoff Institute for Molecular Sciences. The AutoLC workflow builds on concepts originally introduced by Schoenmakers in 1978, which have now been adapted and extended within a modern, automated framework by the AutoLC team. Schoenmakers, who retired in 2022, was awarded the 2023 LCGC Lifetime Achievement Award." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HIMS_From_left_to_right_Bob_Pirok_Prof_Peter_Schoenmakers_Ph_D_candidate_Gerben_van_Henten_and_postdoc_researcher_Tijmen_Bos_in_the_Auto_LC_lab_at_the_Van_t_Hoff_Institute_for_Molecular_Sciences_a4fe9bc6f7.jpg 245w," sizes="100vw" width="700" height="425">He is especially grateful to his students who continuously challenge assumptions and push the technology further. “They show why research and education belong together”, he says. “In fact, education is central to how I approach research. Many of the ideas behind AutoLC grew directly from discussions with students, in the lab, in courses, or while trying to explain complex concepts in a clear and accessible way. Seeing students grow into independent scientists, capable of questioning methods and building new ones, is one of the most rewarding aspects of my work.”&nbsp;<blockquote><h5>About Bob Pirok</h5>Bob Pirok (Den Helder, 1987) completed his MSc in analytical chemistry at the University of Amsterdam, followed by doctoral research conducted in close collaboration with industrial partners including Shell, DSM, and Heineken. After earning his PhD in 2019 with Prof. Peter Schoenmakers, Pirok was appointed tenure-track assistant professor at the Van ’t Hoff Institute for Molecular Sciences. There, he co-founded the Chemometrics and Advanced Separations Team (CAST) and was appointed associate professor in 2025.Pirok is also a visiting researcher at Gustavus Adolphus College in the United States and Stellenbosch University in South Africa. Pirok has received the Shimadzu Young Scientist Award (2015), the Csaba Horváth Young-Scientist Award (HPLC 2017), and the Journal of Chromatography Young-Scientist Award (2018). He is a driving force within the University of Amsterdam’s analytical chemistry programs, where he teaches courses in chemometrics, statistics, and separation science and supervises many MSc and BSc students. Pirok serves on the Early Career Board of Analytical Chemistry and is active in professional networks such as the European Chemistry Thematic Network.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HIMS_Bob_Pirok_speaking_at_the_Balaton_2025_symposium_in_Siofok_Hungary_in_September_2025_106d7cffb5.jpg" alt="HIMS: Bob Pirok speaking at the Balaton 2025 symposium in Siófok, Hungary, in September 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HIMS_Bob_Pirok_speaking_at_the_Balaton_2025_symposium_in_Siofok_Hungary_in_September_2025_106d7cffb5.jpg 204w," sizes="100vw" width="857" height="655"></blockquote>

Bob Pirok receives LCGC Emerging Leader award

Join analytical chemist Dr. M. Farooq Wahab from the University of Texas at Arlington as he breaks down the science behind chromatographic peak shapes in this episode of the Concentrating on Chromatography podcast. Perfect for undergraduate chemists and researchers alike, this conversation covers:<ul><li>What makes an ideal chromatographic peak shape and why it matters &nbsp;</li><li>Common reasons your HPLC peaks might show tailing, fronting, or distortion &nbsp;</li><li>Practical tips for diagnosing and troubleshooting peak shape problems &nbsp;</li><li>How to use visual and digital tools (like Excel) to analyze your chromatogram data beyond basic numbers &nbsp;</li><li>The importance of baseline correction, denoising, and signal processing in chromatography &nbsp;</li><li>Advice for students and early researchers aiming to excel in analytical chemistry</li></ul>Dr. Wahab shares lively insights from his research and decades of experience, revealing the underlying physics, chemistry, and engineering behind the peaks you see—and why peaks tell the story of your chromatography.Whether new to HPLC or looking to deepen your understanding, this episode demystifies a critical topic that impacts every chromatographer.<h3>Video Transcription</h3>The interview with Dr. M. Farooq Wahab focuses on why chromatographic peak shape matters and how it can be used as a practical diagnostic tool. He explains that the ideal peak is a narrow, symmetric Gaussian shape because it’s easier to detect and integrate reliably, but real peaks often show tailing, fronting, broadening, or splitting, which can compromise quantitation and interpretation.Dr. Wahab groups the main causes of distorted peaks into three buckets: thermodynamic effects (overloading the column’s capacity), kinetic effects (multiple interaction sites causing slow desorption and tailing), and fluid-dynamic/packing effects (non-uniform packed beds leading to fronting, tailing, or split peaks). He also highlights chemical interactions with metal surfaces in LC hardware—especially strong binding of phosphate-containing compounds to iron/steel—that can cause severe tailing or even complete loss of the analyte, sometimes requiring cleaning with chelators like EDTA.He cautions that single-number metrics such as tailing factor or asymmetry are convenient but can hide important details, so analysts should assess the full peak profile, using more advanced evaluations (e.g., Gaussian/derivative-style tests) when needed. For troubleshooting, he recommends “back to basics” benchmarking: run the manufacturer’s QC method on a new column to separate instrument issues from method/column/operator errors.Finally, the discussion broadens to data handling and career advice. Dr. Wahab argues for reproducible, transparent data analysis (sharing code/supporting files) and encourages students to use accessible tools like Excel (and carefully verified AI help) to explore peak diagnostics, denoising, and baseline correction—often best understood via frequency-domain thinking. He closes by advising young scientists to build skills across the “four pillars” of analytical chemistry: chemistry, physics, mathematics, and scientific computation, and to pursue science with passion and realistic expectations.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

HPLC Peak Shapes Explained: Why Your Chromatography Peaks Are Not Perfect & How to Fix Them

Article

Video

Scientists

Interview

Science and research

The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

The University of Amsterdam is one of the largest comprehensive universities in Europe. With some 40,000 students, 6,000 staff, 3,000 PhD candidates, and an annual budget of more than 850 million euros, it is also one of Amsterdam’s biggest employers.

There is an inseparable link between the university and its host city. The freedom and creativity with which Amsterdam has long been associated have worked their way into the fabric of the university. This is a place where individuality, authenticity and diversity are celebrated as sources of stimulation, inspiration and innovation.

Professional and personal development, challenges and collaboration are undertaken in a versatile and multidimensional (inter)national ecosystem with leading stakeholders. Staff at the UvA make a meaningful contribution to uncovering solutions to some of the world’s most significant problems and to developing the next generation of talent.

University of Amsterdam

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Tosoh Bioscience

Separation Science

Merck

Thermo Fisher Scientific

Waters Corporation

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 4: Thursday, 13 February</h3><h4>Greener Solvents - Making Big Moves for More Sustainability in the Lab!</h4>Laboratories consume significantly more energy and water and generate more waste than offices or households. This is more reason for laboratories to tackle sustainability concerns now. This training supports labs to become greener by addressing the class of chemicals that are used in the largest volumes in the lab: solvents! According to the 12 Principles of Green Chemistry, solvents are more sustainable when they are biobased or when they are less dangerous and hazardous.This training highlights several of these greener solvent alternatives and how they can be implemented in the lab. Due to the large volume in which solvents are used, changing to a greener alternative will significantly reduce the carbon footprint of a lab. A further opportunity to reduce the carbon footprint of a lab and to tremendously reduce waste, are returnable containers for solvents, which will be covered in the second part of the training.By attending this webinar, you will learn:<ul><li>The 12 Principles of Green Chemistry</li><li>What greener solvents are and how they can be implemented in your lab</li><li>How returnable containers for solvents reduce the carbon footprint and amount of waste in the lab</li></ul>Who should attend: This webinar will provide valuable insights for everybody who is working with solvents in the lab and would like to become more sustainable. This includes lab technicians, lab managers, and scientists in chemistry and analytical chemistry labs.<blockquote>Presenter: Frank Michel, (Scientific Education &amp; Sustainability, Chemistry Franchise, Merck)Presenter: John Cooper, (Global Product Manager Sustainable Solvents, Milwaukee, Wisconsin, USA, an affiliate of Merck)</blockquote><h4>Tips and Tricks for LC-MS Troubleshooting</h4>LC-MS is an excellent tool for chemical analysis. Moreover, the evolution in HPLC particle technology, HPLC instrument design, and MS detection resulted in improved performance and sensitivity. This raised the bar on requirements for the purity of the solvents and additives in the mobile phase. This training provides valuable tips and tricks on how to get the best performance out of your LC-MS instrument regarding sensitivity and how to limit instrument downtime by different approaches. Typical examples of LC-MS issues, such as ghost peaks or noisy and elevated baselines, and how to prevent them will be presented. Advanced LC-MS solvents and additives for improved LC-MS performance and their proper handling will be discussed in detail.By attending this webinar, you will learn:<ul><li>The importance of the choice of consumables and solvents for LC-MS</li><li>Approaches to improve sensitivity and robustness of LC-MS</li></ul>Who should attend: This webinar will be especially valuable for scientists, lab managers, and lab technicians working with LC-MS in any application area.<blockquote>Presenter: Frank Michel, (Scientific Education &amp; Sustainability, Chemistry Franchise, Merck)</blockquote>

Merck: Webinar Series & Expert Roundtable

Webinar Series & Expert Roundtable (Day 4)

Part 1: Greener Solvents - Making Big Moves for More Sustainability in the Lab! and Part 2: Tips and Tricks for LC-MS Troubleshooting.

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 5: Friday, 14 February</h3><h4>Roundtable Expert Discussion</h4>Our experts will come together to discuss the best practices to streamline your analytical workflows and enhance your efficiency. We will cover some questions asked during the week, as well as answer new questions during the roundtable discussion. &nbsp;<blockquote>Presenter: Ernie Hillier (Independent Pharmaceutical Consultant, EJH Consulting)</blockquote>

Webinar Series & Expert Roundtable (Day 5)

Webinar Series & Expert Roundtable (Day 5) - Roundtable Expert Discussion

<h5>A New Chapter for Regulated Labs Begins Now</h5>Are You Ready to Revolutionize Your LC-MS/MS Workflows?Imagine a workflow that’s not only faster and more efficient but also equipped with compliance-enabled capabilities to meet the demands of regulated environments.Are you ready to make that change for the better?We’re excited to invite you to a webinar that will unlock the future of LC-MS/MS data processing in regulated pharmaceutical environments.In this session, we’ll demonstrate how waters_Connect for Quantitation 3.0 is streamlining workflows, boosting efficiency, and, enhancing data integrity, and compliance. Whether you're in a regulated or non-regulated lab, don’t miss the chance to explore how these advancements can redefine your laboratory’s potential.What you will discover:<ul><li>Efficiency-driven processing that reduces data review time by up to 50%</li><li>Built-in guidance with application-focused workflows and software</li><li>Data integrity tools for secure, traceable, and compliant workflows</li><li>Seamless connectivity for mixed-platform environments</li></ul>Don’t just take our word for it - join our webinar to see waters_connect for Quantitation 3.0 in action.<blockquote>Presenter: Nat Martin (Principal Consulting Product Owner, Waters Corporation)With over nine years at Waters Corporation, Nat is the Principal Consulting Product Owner for waters_connect for Quantitation. Drawing on extensive experience as a chemist and research scientist, including a key role in the discovery of osimertinib (Tagrisso) at AstraZeneca, Nat brings deep expertise in both scientific innovation and product development.</blockquote>

Waters Corporation: Maximize LC-MS/MS Efficiency & Accuracy: A Glimpse into the Future for Regulated Pharma

Dominate Your LC-MS/MS Data, Maximize Efficiency and Bolster Regulatory Compliance with waters_connect for Quantitation 3.0

How groundbreaking software is transforming LC-MS/MS workflows, delivering faster, more accurate quantitation, and future-proofing your laboratory operations.

Dominate Your LC-MS/MS Data with Quantitation 3.0

<h5>By attending this discussion, you will:</h5><ul><li>Discover how automated control algorithms enhance precision and reduce titration times without compromising accuracy.</li><li>Understand how advanced drift management tools ensure reliable results, even in demanding conditions.</li><li>Explore how modern titration systems address safety and sustainability goals with features such as remote operation and support for greener solvents.</li></ul><h5>Event Overview</h5>For nearly a century, Karl Fischer titration has been the trusted method for determining water content in products ranging from pharmaceuticals to processed snacks. However, even reliable techniques face challenges. For example, antibiotics can be difficult to analyze due to their limited solubility in conventional solvents, often requiring additional heating steps to ensure accurate measurements. Environmental factors, such as humidity, can further complicate workflows by introducing drift and reducing precision.Join us for an expert discussion exploring how the latest innovations in Karl Fischer titration technology tackle these issues head-on. Panelists Nicolas Monney (Application Chemist, Mettler-Toledo) and Matteo Stefanoni (Senior Scientist, Mettler-Toledo) will answer questions related to advancements such as high-resolution sensors, low-dead-volume burets, and modular designs that improve accuracy, safety, and workflow efficiency. Learn how the EVA KF Titrator’s Fast Feedback Algorithm redefines titration workflows by adapting in real time to reaction conditions.<h5>Who Should Attend:</h5><ul><li>Scientists, lab managers, and analysts working in water determination across industries, including pharmaceuticals, food, biopharma, and materials science.</li><li>Professionals seeking practical solutions to improve accuracy, efficiency, and reproducibility in Karl Fischer titration workflows.</li><li>Anyone facing challenges with complex samples, drift, or evolving regulatory requirements in moisture analysis.</li></ul><h5>Share Your Challenges Across Industries</h5>Water determination plays a pivotal role in advancing quality and innovation. Do you struggle with reactive compounds, complex sample matrices, or meeting regulatory demands? This event offers the chance to have your specific questions addressed by experts.Submit your questions through the webinar registration form, and our panel will address selected challenges during the broadcast.<blockquote>Presenter: Nicolas Monney (Application chemist, Mettler-Toledo)Nicolas Monney holds a Ph.D. in Physical Chemistry. His research focused on studying electron transfer through proteins using low-temperature spectroscopy and ab-initio simulations.Nicolas began his career at Mettler-Toledo nearly ten years ago, taking on the role of Applications Specialist for Titration. In this role, he develops innovative titration applications and collaborates closely with the R&amp;D department to facilitate the development of new products. Additionally, he supports the sales force of Mettler-Toledo and its partners on titration projects worldwidePresenter: Matteo Stefanoni (Senior Scientist, Mettler-Toledo International)Matteo is a scientist with a strong academic background and experience in the fields of chemistry and material science. He earned his Master’s degree in Chemistry from the University of Milano and a PhD from ETH Zürich, focusing on electrochemistry. After completing his doctoral studies, Matteo spent two years as a postdoctoral researcher, further enhancing his expertise in the field. Currently, Matteo serves as a Senior Scientist at Mettler-Toledo, where he has spent the last five years developing advanced control algorithms for automatic titration instruments. Notably, he has dedicated four of those years to developing an innovative model-based control algorithm for Karl Fischer titration analysis, significantly improving the efficiency of this analytical technique.</blockquote>

Separation Science: Rethinking Karl Fischer Titration: How Smarter Algorithms Tackle Complex Water Determinations

Rethinking Karl Fischer Titration: How Smarter Algorithms Tackle Complex Water Determinations

Join us for an expert discussion exploring how the latest innovations in Karl Fischer titration technology tackle issues.

KF Titration: Smarter Algorithms Tackle Water Determinations

The presentation focuses on advancements in proteomics and metabolomics, emphasizing robust, large-scale, and high-throughput analysis. Key points include the development of assays that operate 24/7 with minimal carryover and high dynamic range, essential for precision medicine.The presentation highlights the importance of translating findings from human samples to preclinical and clinical models, aiding in target identification and biomarker discovery. It discusses the use of microflow and capillary flow rates to improve sensitivity and the application of multiple technologies to analyze plasma and other biofluids. Case studies, such as those involving respiratory distress syndrome patients, demonstrate the identification of proteins and pathways affected by treatments.The presentation underscores the need for standardization in sample preparation and the integration of various proteomics technologies to enhance disease understanding and biomarker validation.Learning points :<ul><li id="isPasted">Advancements in Proteomics and Metabolomics: Learn about the latest technologies and methodologies that enable large-scale, high-throughput, and robust proteomics and metabolomics analyses, essential for precision medicine.&nbsp;</li><li>Translational Research Applications: Understand how findings from human samples can be translated to preclinical and clinical models, aiding in target identification, biomarker discovery, and disease mechanism elucidation.&nbsp;</li><li>Standardization and Integration: Explore the importance of standardizing sample preparation and integrating multiple proteomics techniques to improve the accuracy and reliability of biomarker validation and disease understanding.&nbsp;</li></ul>Who should attend?<ul><li id="isPasted">Translational Scientists and Researchers: Those involved in drug development, target identification, and precision medicine will benefit from understanding the latest advancements in proteomics and metabolomics for translating findings from human samples to preclinical and clinical models.&nbsp;</li><li>Clinical and Preclinical Model Developers: Professionals working on developing and validating clinical and preclinical models to better understand disease mechanisms and identify new biomarkers will find the presentation valuable.&nbsp;</li><li>Biomarker Discovery and Validation Experts: Individuals focused on the discovery and validation of biomarkers in biofluids and tissues, particularly those looking to standardize sample preparation and integrate multiple proteomics technologies, will gain important insights.</li></ul><h5>Additional Webinars</h5>Take advantage of our growing library of convenient and educational recorded webinars and resources. <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/about-us/events/industrial/analytical-innovations-webinars.html?cid=E.24CMD.EL112.21227.01">Visit our webinars page</a><blockquote>Presenter: Dr. Alexander Boychenko (Head of R&amp;D Laboratory Precision Medicine Markers Bayer)Alexander Boychenko is leading Omics Research within the Translational Sciences team of the ​Pharmaceuticals division at Bayer Group. He is focused on implementing innovative analytical ​technologies and developing novel methodologies for proteomics, metabolomics, and ligand-binding ​assays (LBA) to comprehensively characterize human and animal model phenotypes, enabling disease ​understanding and novel biomarker discovery. He holds a Ph.D. in Analytical Chemistry from Kharkiv ​National University, Ukraine. During his post-doctoral work at the University of Groningen, The ​Netherlands, he combined LC-MS and immunoassays to discover and validate protein biomarkers in ​biofluids for cancer screening. Before joining Research and Early Development at Bayer AG, he ​developed and introduced new liquid chromatography-mass spectrometry products at Thermo Fisher ​Scientific. Alexander is a subject matter expert in LC-MS, biological data interpretation, and precision ​medicine. He utilizes his passion for applying technical expertise to develop new medicines.​</blockquote>

Thermo Fisher Scientific: iHUPO 2024 Reloaded Webinar series

Tandem Micro-Flow LC-MS Proteome Analysis of Urine and Plasma to Unravel Disease ​Mechanisms and Biomarker Discovery ​​​​

The presentation focuses on advancements in proteomics and metabolomics, emphasizing robust, large-scale, and high-throughput analysis.

Tandem Micro-Flow LC-MS for Proteome Analysis in Biomarkers

The presentations on Orbitrap Astral highlight significant advancements in proteomics and metabolomics. The first presentation from Alexey Chernobrovkin focuses on the integration of high throughput and high sensitivity mass spectrometry, demonstrating how the latest generation of mass spectrometers, coupled with advanced LC systems like the Vanquish Neo, can significantly increase sample processing speeds while maintaining robust protein coverage. This setup allows for efficient and reproducible results in quantitative proteomics, even with high sample loads, making it ideal for large-scale screening and clinical applications.&nbsp;The second presentation from Giada Marino delves into the predictive capabilities of machine learning models in retention time prediction for LC-MS experiments. It showcases the development and application of models like DeepLC, which use neural networks to predict retention times, collision cross sections, and fragment densities. These predictions enhance the identification and quantification of biomolecules, offering a more comprehensive understanding of proteomic and metabolomic profiles. The integration of modifications and transfer learning further improves the accuracy and applicability of these predictions across different experimental setups.&nbsp;Learning points :<ul><li id="isPasted">High Throughput and Sensitivity: The integration of high-throughput mass spectrometry with advanced LC systems like the Vanquish Neo significantly enhances sample processing speeds and maintains robust protein coverage. This setup is ideal for large-scale proteomics and clinical applications, enabling the processing of up to 200 samples per day.&nbsp;</li><li>Machine Learning for Retention Time Prediction: The development and application of machine learning models, such as DeepLC, improve the prediction of retention times, collision cross sections, and fragment densities. These predictions enhance the identification and quantification of biomolecules, providing a more comprehensive understanding of proteomic and metabolomic profiles.&nbsp;</li><li>Optimization and Flexibility in Chromatography: The use of optimized LC setups and tailored columns ensures maximum performance and reproducibility in quantitative proteomics. The flexibility to choose the right column for specific project needs, coupled with extensive QC and optimization, allows for efficient and reliable results in various experimental conditions.</li></ul>Who should attend?<ul><li id="isPasted">Proteomics and Metabolomics Researchers: Scientists working in the fields of proteomics and metabolomics will gain insights into the latest advancements in mass spectrometry and chromatography, enhancing their research capabilities.&nbsp;</li><li>Clinical Laboratory Professionals: Those involved in clinical diagnostics and large-scale screening will benefit from understanding how high-throughput and high-sensitivity mass spectrometry can improve sample processing and data accuracy.&nbsp;</li><li>Data Scientists and Bioinformaticians: Professionals focused on developing and applying predictive models in biological research will learn about the integration of machine learning for retention time prediction, enhancing their analytical toolkit.&nbsp;</li></ul><h5>Additional Webinars</h5>Take advantage of our growing library of convenient and educational recorded webinars and resources. <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/about-us/events/industrial/analytical-innovations-webinars.html?cid=E.24CMD.EL112.21227.01">Visit our webinars page</a><blockquote>Presenter: Alexey Chernobrovkin (Principal Scientist, Pelago Bioscience AB)​<div>Alexey Chernobrovkin, Principal Scientist at Pelago Bioscience. With a background in ​applied physics (MSc, MIPT, Moscow), got his PhD in Bioinformatics (Institute of ​Biomedical Chemistry, Moscow) and thenmoved for a postdoc at Karolinska Institutet, ​Stockholm in the group of prof. Roman Zubarev. At Pelago Bioscience AC leads ​development of MS-based platform for proteome-wide deconvolution of targets and ​mechanism of action (MoA) of bioactive compounds.​Presenter: Giada Marino​ (Senior Research Scientist, Evotec)<div>Dr. Giada Marino is a Senior Research Scientist at Evotec working on high sensitivity ​and high throughput proteomics applications. Giada has more than 10 years of ​experience in proteomics and mass spectrometry. After a postdoc in Chris Overall ​lab at UBC (Vancouver, Canada) focusing on N-terminomics applications, she managed ​the mass spectrometry core facility in the Biology Department at the Ludwig-Maximilian ​University working on a wide range of protein and peptide mass spectrometry projects.​</div></div></blockquote>

Breakthroughs in Proteomics and Metabolomics

The presentations on Orbitrap Astral highlight significant advancements in proteomics and metabolomics.

Join our upcoming webinar, and discover a comprehensive solution for PFAS analysis, from sample preparation to reporting, tailored to meet European regulatory standards. PFAS encompass several chemical classes, making their extraction and analysis complex. This webinar will introduce a cutting-edge automated sample preparation method to overcome the challenges of PFAS extraction and concentration. Utilizing automated dispersive liquid-liquid microextraction (DLLME), we present a simple, cost-effective, and versatile technique to enhance PFAS detection sensitivity compatible with LC-MS and GC-MS systems. &nbsp;<h5>Discover:</h5><ul><li id="isPasted">Technique for extracting and analyzing various PFAS classes&nbsp;</li><li>An introduction to automated dispersive liquid-liquid microextraction (DLLME)</li><li>How to enhance PFAS detection sensitivity</li></ul><h5>Who should attend:</h5><ul><li id="isPasted">Scientists involved in water quality/contaminant monitoring.</li><li>Regulatory professionals focused on water standards.</li><li>Analytical chemists specializing in PFAS detection and analysis.</li><li>Laboratory professionals seeking efficient and cost-effective sample preparation methods</li></ul>This session includes a recording from the Thermo Fisher Scientific event "Live from the Lab. After the presentation, our product application specialists will be available live to answer your questions in real-time.&nbsp;Register now to secure your spot to join our specialists live or to watch the recording at your convenience.<blockquote>Presenter: Aristide Ganci (Product Manager EFS, Thermo Fisher Scientific)Aristide is an experienced environmental and food testing chemist now specialising in developing LC- and GC-MS analytical workflows to support laboratories in the food and beverages industry. He gained his environmental analytical chemistry PhD for researching POPs at the University of Birmingham, UK.Presenter: Valérie Thibert (Senior Product Applications Specialist, Thermo Fisher Scientific)Valérie holds a PhD from the University Pierre et Marie Curie in France in Analytical Chemistry and has wide ranging experience in clinical toxicology and environmental and food contaminant analysis. Today her work focuses on helping customers in environmental and food safety laboratories with their LC-MS methods needs.Presenter: Jeff Stubbs (Senior Business Development Manager – Environment and Food, Thermo Fisher Scientific)Jeff began his career at Northumbrian Water over 20 years ago, performing routine analysis and developing and validating methods. Jeff has utilised his extensive water industry and commercial experience to work with environmental and food testing laboratories, understand their challenges and create long-term successful collaborative partnerships.</blockquote>

Thermo Fisher Scientific: Detecting PFAS in drinking water for regulations in Europe

Detecting PFAS in drinking water for regulations in Europe

Discover a comprehensive solution for PFAS analysis, from sample preparation to reporting, tailored to meet European regulatory standards. 

The power of metabolomics can provide vast insights into biological systems, delivering information about the biochemistry of a person, plant or animal, as well as the microbiome, the exposome, and lifestyle factors. To deliver on this promise, it is critical to identify putative metabolites with confident annotation while determining which analytes are transitioned into a targeted method. The challenge is in determining the species metabolome when a large section remains uncharacterized and with no reference standards to perform validation.This webcast will describe how the Patti lab has developed comprehensive LC-MSn techniques to confidently profile biological samples using novel untargeted data acquisition schemes and software. Discovery results obtained using Thermo Scientific Orbitrap-based mass spectrometers enable methods to filter between 5,000 and 20,000 features into ~1,500 unique features comprised of knowns, known unknowns, and unknowns. The goal is now to leverage the unique innovations of the Thermo Scientific Stellar mass spectrometer to perform targeted quantitation on the set of identified metabolites using fast gradients to handle increased study size.The speakers will describe key instrumental features such as fast and sensitive MS, MS2, and MS3 acquisition to expedite highly multiplexed targeted data acquisition methods using higher energy collisional dissociation (HCD) and collisional induced dissociation (CID), as well as novel automated instrument control features that deliver fast, sensitive, and reproducible data acquisition to verify putative biomarkers.You will learn:<ul><li>How to acquire and process untargeted data to identify putative metabolite biomarkers</li><li>How to leverage the untargeted data to automate highly multiplexed LC-MSn acquisition on the Stellar mass spectrometer</li><li>The analytical capabilities of Stellar mass spectrometer to acquire fast and sensitive targeted-MS2 and -MS3 to expand quantitative assessment to a wider range of molecular species</li></ul><blockquote>Presenter: Gary Patti (Senior Director Center for Mass Spectrometry &amp; Metabolic Tracing, Washington University)Gary Patti, PhD, is the Michael and Tana Powell Professor at Washington University in St. Louis, in the departments of chemistry, genetics, and medicine, the Senior Director of the Center for Mass Spectrometry &amp; Metabolic Tracing, Director of the Clinical Research Core in Medicine, and CSO and Co-Founder of Panome Bio.Presenter: Bashar Amer (Metabolomics Vertical Marketing Manager, Thermo Fisher Scientific)Bashar Amer, PhD, a Metabolomics Vertical Marketing Manager and Metabolomics scientist on Thermo Fisher Scientific's vertical marketing team, specializes in LC-MS and GC-MS technologies. His work involves developing end-to-end metabolomics workflows using innovative Thermo Scientific Orbitrap- and linear ion trap-based mass spectrometers and advanced software solutions.Moderator: Alison Halliday (Freelance Science, Writer)Alison Halliday, PhD, is a freelance science writer, focusing on life sciences, bio medicine and health stories. Following her doctorate at the University of Newcastle and postdoctoral research into human molecular genetics at University College London, she moved into science communications. With more than 25 years of experience spanning academia, industry and non-profit sectors – including a decade at Cancer Research UK – she has collaborated with Nature Research Custom Media since 2019.</blockquote>

Thermo Fisher Scientific: Targeted metabolic profiling at untargeted scale

Targeted metabolic profiling at untargeted scale

comprehensive LC-MSn techniques to confidently profile biological samples using novel untargeted data acquisition schemes and software.

<div><div>Let's go back to the Basics of Chromatography, Mass Spectrometry, Data Analysis and Trouble-shooting: understanding the importance of the basics will enable you to be more effective in your daily laboratory life.This journey started in 2024 and we are now pleased to invite you to join us to go deeper in fundamentals, troubleshooting and application specific topics.<h3>EPISODE 1: SPE Troubleshooting - Keys to Success!</h3>What will you learn?<ul><li>What are the critical steps in a SPE protocol</li><li>How to overcome the most common challenges</li></ul>What's next?<ul><li>Check out the full Webinar Series Episodes List <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/eventRegistration/EventLobbyServlet?target=reg20.jsp&amp;eventid=4817889&amp;sessionid=1&amp;key=B9182AE813B3F8A30217606156F96B75&amp;groupId=5901784&amp;sourcepage=register">here</a></li></ul>Not sure to be able to attend live sessions?&nbsp;<ul><li>Register today and watch the webinars on-demand</li></ul><blockquote>Presenter: Xavier Rodriguez (Principal Applications Specialist, Chemistry, Europe, Waters Corporation)Xavier is part of the European Market Development Team. He works as an Application Specialist with focus on sample prep and has more than 20 years of experience in solving sample prep challenges.</blockquote></div></div>

Waters Corporation: Back to Basics Advanced Webinar Series 2025

Back to Basics Advanced - Troubleshooting: Sample Prep

What are the critical steps in a SPE protocol and how to overcome the most common challenges 

Christian Rohrer, Director Sales and Support at Tosoh Bioscience GmbH, will present the next edition of Tosoh Tuesday, a webinar series held by Chromatography Experts.&nbsp;On Tuesday February 18, Andrea Krumm, Product Manager at Tosoh Bioscience, explores the versatility of hydrophobic interaction chromatography (HIC) for analyzing small and large proteins, as well as nucleic acid-based molecules.&nbsp;Discover how the availability of diverse stationary phases extends HIC beyond ADC analysis, unlocking its potential for a broader range of applications.After the webinar, ask your questions during the live Q&amp;A session.&nbsp;<blockquote>Presenter: Christian Rohrer (Director Sales and Support at Tosoh Bioscience GmbH)Presenter: Andrea Krumm (Product Manager at Tosoh Bioscience)</blockquote>

Tosoh Bioscience: Tosoh Tuesday - Analytical HIC for Diverse Biomolecules: Selectivity is Key!

Tosoh Tuesday - Analytical HIC for Diverse Biomolecules: Selectivity is Key!

Learn how analytical HIC extends beyond ADCs to analyze proteins and nucleic acid molecules, offering unique selectivity and versatile applications.

Related content

HPLC Peak Shapes Explained: Why Your Chromatography Peaks Are Not Perfect & How to Fix Them

Bob Pirok receives LCGC Emerging Leader award

Czech scientists develop a material for producing chemicals from water and sunlight, inspired by human enzymes