In German, there is a well-known saying: “Der April macht, was er will!” — loosely translated as “April does whatever it wants.” While this usually refers to unpredictable weather, it can sometimes describe other situations just as well.As an analytical application specialist at KNAUER, I was genuinely excited when, at the end of 2023, my colleague and product manager Mareike Myrach and I were assigned the project of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1454">Liquid Handler LH 8.1</a>. At that time, we had no prior hands-on experience with the system, but we quickly got up to speed — largely because learning by doing turned out to be surprisingly intuitive.Following an intensive phase of testing, method development, and optimization, the Liquid Handler LH 8.1 was officially introduced by KNAUER in April 2025. Returning to the April proverb — this time, April behaved quite differently. Rather than being unpredictable, everything came together smoothly (even if not weather-wise!). All documentation was finalized, product configurations defined, and specifications locked in. It was a very satisfying milestone.&nbsp;<h3>What makes the Liquid Handler LH 8.1 stand out?</h3>Let’s take a closer look at some of its key features.<h4>Flexible configuration tailored to your workflow</h4>The KNAUER LH 8.1 is a highly customizable XYZ autosampler designed to adapt to a wide range of laboratory requirements. It supports numerous modules and accessories, allowing users to build a system that fits their specific applications.Core components include the injection valve, the Robotic Cooler, and the fast wash station — all essential for efficient operation. Beyond these, we are continuously exploring additional enhancements.&nbsp;For example, how about seasonal upgrade kits?<ul><li>LH 8.1 Easter edition</li><li>LH 8.1 Christmas edition</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_1_Left_LH_8_1_Upgrade_Kit_7b9a711bab.jpg" alt="KNAUER: Fig. 1: Left: LH 8.1 Upgrade Kit “Easter”, right: LH 8.1 Upgrade Kit “Christmas” (limited availability — only 1 in stock!)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_1_Left_LH_8_1_Upgrade_Kit_7b9a711bab.jpg 234w," sizes="100vw" width="1263" height="843"><h4>Flexible sample storage and high-throughput capability</h4>For laboratories focused on high-throughput analysis, the Robotic Cooler module is indispensable. Each unit can accommodate up to three sample racks, with 130 vials per rack — totaling 390 vials per module.Depending on the rail length, multiple Robotic Coolers can be installed and operated independently. On the longest rail configuration, up to three modules can be used simultaneously, increasing the total capacity of a single LH 8.1 system to as many as 1,170 vials (1.5 mL each).Naturally, the system is not limited to standard vials. It can store a variety of sample types within a temperature range of 4–40 °C.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_2_Left_Tray_with_common_samples_middle_tray_with_special_samples_right_very_very_special_samples_b1d2e3daea.jpg" alt="KNAUER: Fig. 2: Left: tray with standard samples, middle: tray with specialized samples, right: very special samples" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_2_Left_Tray_with_common_samples_middle_tray_with_special_samples_right_very_very_special_samples_b1d2e3daea.jpg 245w," sizes="100vw" width="1176" height="402"><h4>True zero sample loss</h4>Have you ever encountered the concept of “sandwich injections” in liquid chromatography? It may sound unusual at first. Replace the bread with standard HPLC solvents and the filling with your sample, separated by small air gaps — and you have a liquid “sandwich.”The LH 8.1 takes this concept even further. It allows sampling from virtually any container type. Whether it’s a standard vial or something more unconventional — like a filled chocolate egg — the system can handle it. The result? A rather creative “egg sandwich.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_3_Left_Exemplary_sandwich_build_up_right_aspiration_from_double_coated_chocolate_sample_container_8e9f9fa243.jpg" alt="KNAUER: Fig. 3: Left: example of sandwich configuration, right: aspiration from a chocolate-based sample container" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_3_Left_Exemplary_sandwich_build_up_right_aspiration_from_double_coated_chocolate_sample_container_8e9f9fa243.jpg 245w," sizes="100vw" width="1218" height="751"><blockquote>Please note: using such unconventional containers may significantly increase both carryover and... enjoyment.</blockquote><h4>Carryover and injection precision</h4>When evaluating HPLC injectors, injection precision is one of the most critical parameters. After optimizing the injection conditions, we achieved excellent performance.To ensure ease of use, all optimized parameters have been integrated into the software drivers. This allows users to benefit from high precision without complex programming.<h5>Injection precision (RSD):</h5><ul><li>Full loop injection: ≤ 0.10%</li><li>Sandwich injection (&gt;5 µL): ≤ 0.15%</li></ul>Another key parameter is sample carryover, evaluated using recommended washing protocols. During testing, we measured carryover using chlorhexidine as a standard compound to allow comparison with other autosamplers. Additionally, caffeine was tested due to its widespread use and accessibility in laboratories.Taking advantage of the LH 8.1’s flexibility, we also explored sampling from unconventional containers.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_4_Exemplary_sample_take_up_for_the_determination_of_carry_over_47706172c7.jpg" alt="KNAUER: Fig. 4: Left: injection of diluted caffeine sample for quantification, right: injection of concentrated sample for carryover assessment" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_4_Exemplary_sample_take_up_for_the_determination_of_carry_over_47706172c7.jpg 224w," sizes="100vw" width="1248" height="870"><h5>Measured carryover values:</h5><ul><li>Chlorhexidine: &lt; 0.005%</li><li>Caffeine: &lt; 0.002%</li></ul>Returning to the beginning of this article — you may have noticed that not only “April does whatever it wants,” but sometimes KNAUER blog authors do as well.Despite the seasonal theme, we hope you discovered a few hidden “Easter eggs” throughout the text — and didn’t take everything too seriously.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_5_KNAUER_blog_authors_72de1a0c72.jpg" alt="KNAUER: Fig. 5: KNAUER blog authors" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_5_KNAUER_blog_authors_72de1a0c72.jpg 237w," sizes="100vw" width="1150" height="757"><blockquote><ul><li>More reputable information: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1454">KNAUER Liquid Handler LH 8.1</a></li><li>For further information on this topic, please contact our author: kramer@knauer.net, m.myrach@knauer.net</li></ul></blockquote>

Seasonal update on liquid handling

🎤 Presenter: Chris Topper (Clemson University)💾 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_13_Topper_db3de8f032.pdf">PDF presentation</a><h3>Abstract</h3>Extracellular vesicles (EVs) are small membrane-bound particles that are naturally released by cells into the extracellular environment. Exosomes constitute a subset of EVs with a characteristic size range of 30 – 150 nm. Exosomes are produced by nearly every cell type in the body and can be found in virtually all biological fluids. They share the same integral membrane proteins as their originating cell and thus can be used as biomarkers to identify and monitor disease.Monoclonal antibodies (mAbs) such as IgG are primarily produced by culturing Chinese hamster ovary (CHO) cells and then passing the culture media through a Protein A (ProA) affinity chromatography column to isolate the antibodies. The waste effluent from this process, however, contains valuable EVs that are ultimately discarded. Therefore, the isolation of exosomes from CHO cell waste streams presents an opportunity for by-product valorization.We describe a two-dimensional liquid chromatography platform employing columns packed with capillary-channeled polymer (C-CP) fibers to isolate both IgG and exosomes from CHO cell supernatant. The first dimension utilizes ProA to isolate and quantify IgG, while hydrophobic interaction chromatography (HIC) is used in the second dimension to isolate and quantify exosomes from the 1D effluent. Thus, we demonstrate a convenient framework for characterizing any CHO cell culture into both its IgG and exosome production traits, providing practical insights into the co-production of these two, disparate biotherapeutics, as well as a means for extracting valuable EVs during the production of mAbs, converting waste into dollars.

Two-Dimensional Liquid Chromatography Isolation and Quantitation of IgG and Exosomes from Cell Culture Media (Chris Topper, MDCW 2026)

News from LabRulezLCMS Library - Week 16, 2026

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Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

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<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>For decades, analyzing proteins has required laborious and time-consuming sodium dodecyl sulfate (SDS) polyacrylamide gels resulting in inconsistent results and limited quantification. Advances in capillary-based separations now offer a faster, more reproducible way to assess protein size, purity and quantity with minimal hands-on time. In this webinar, our expert speakers will highlight the limitations of traditional gels, explore an advanced &nbsp;streamlined approach and demonstrate how capillary electrophoresis technology can improve data quality and free up valuable lab resources. Real-time interaction, through a live Q&amp;A session, will help you translate these insights into action within your own workflow.<h5>Attend this webinar to:</h5><ul><li>Understand modern advancements and how they compare to long-standing techniques</li><li>Learn how an automated separation method can overcome common SDS-gel challenges to improve speed, reproducibility and quantification</li><li>Gain knowledge, with a live demonstration of Agilent’s ProteoAnalyzer system, on how you can modernize your protein analysis strategy</li></ul>For Research Use Only. Not for use in diagnostic procedures.&nbsp;<blockquote>Presenter: Kyle Luttgeharm, PhD (Product Manager, Agilent Technologies)Presenter:&nbsp;Samina Kaufmann (Product Specialist for Sample QC, Agilent Technologies)</blockquote></div></div></div>

Agilent Technologies: A Modern Approach for Reliable Protein Denaturing Electrophoresis

A Modern Approach for Reliable Protein Denaturing Electrophoresis

See how Agilent ProteoAnalyzer improves protein analysis with capillary electrophoresis—faster, reproducible results vs SDS gels, plus a live demo and Q&A.

Approach for Reliable Protein Denaturing Electrophoresis

<h5>Overview</h5><ul><li>During this presentation we will review:</li><li>The differences of fully porous polar C18 and core-shell biphenyl LC column chemistries</li><li>Analyte properties affect LC column retention and selectivity</li><li>LC-MS/MS methods for analysis of antipsychotics, antidepressants and anticonvulsants</li><li>Column solution for LC-MS screening of 48 TDM drug analytes for toxicology applications</li></ul><h5>Key Learning Points</h5><ul><li>Review selectivity and retention on polar C18 and biphenyl column chemistries for antipsychotic, antidepressant and anticonvulsant drugs</li><li>Learn how analyte properties for these drug classes affect LC column choice</li><li>Take a deep dive into optimized LC separations for screening and confirmation of antipsychotic, antidepressant and anticonvulsant drugs</li></ul><h5>Who Should Attend</h5><ul><li>Clinical and forensic toxicologists who want to know which columns to choose for their LC-MS/MS methods for TDM (prescribed) drugs in clinical research and forensic toxicology applications</li></ul><blockquote>Presenter: Stephanie J. Marin, Ph.D (Sr. Global Market Development Manager) Stephanie J. Marin is the Applied Markets Global Market Development Manager at Phenomenex. She received her Ph.D. in chemistry from Arizona State University, and has expertise in sample preparation, liquid chromatography and mass spectrometry. Dr Marin has worked in marketing, product development, method development and method validation, in addition to customer facing roles in technical support, service, education and training. She has over 10 years of experience developing and validating clinical methods from her tenure at the ARUP Institute for Clinical and Experimental Pathology. She has also held positions as an Applications Chemist at Hamilton Company and Biotage, Marketing Manager at Selerity Technologies and as a Group Leader in analytical services for specialty chemicals and polymers at Rohm and Haas (now Dow). She was also a supervisor at an EPA certified laboratory. She is the author of over 30 peer reviewed publications and book chapters and over 100 abstracts presented at national and international meetings.</blockquote>

Phenomenex: LC Columns for Prescribed (TDM) Drug Methods

LC Columns for Prescribed (TDM) Drug Methods

Explore LC column choices for LC-MS/MS screening of TDM drugs. Compare polar C18 vs. biphenyl chemistries and optimize separations for toxicology applications.

<h4>Streamline method workflow for developing and implementing a highly multiplexed targeted metabolite panel covering the gut microbiome</h4>Join our webinar to learn how leveraging empirical databases can streamline the creation of highly-multiplexed LC-MSn acquisition methods, drastically reducing costly standards and lengthy optimization routines, and boosting your laboratory productivity by over 10X.Developing highly-multiplexed LC-MSn acquisition methods to perform analytical quantitation is extremely important. The large scale of targets enables researchers to better determine the biological "big picture" that can be used to assess many different biological conditions. Creating and refining instrument methods to succeed at robust and reproducible quantitation across a wide dynamic range of expression levels is difficult as metabolites cover a range of molecular classes. Each molecular class may require different instrument settings often requiring costly standards and lengthy optimization methods. The focus of this webinar is to demonstrate a new approach to leverage empirical databases to streamline method creation that can reduce the need of standards and lengthy method optimization routines. &nbsp;The demonstrated workflow can truncate previous method optimization steps over 10X boosting laboratory productivity.<blockquote>Presenter: Wes Rogers (Product Management Specialist, Thermo Fisher Scientific)Wes is a Product Management Specialist at Thermo Fisher Scientific for the Thermo Scientific Stellar MS. Before this role, Wes spent the last 3 years as a LC-MS Field Application Scientist at Thermo Fisher Scientific, supporting customers on small and large molecules applications. Prior to joining Thermo Fisher Scientific, Wes spent the majority of his career in sports anti-doping at LGC.Presenter:&nbsp;Marynka Ulaszewska (Product Manager, Thermo Fisher Scientific)Marynka is an analytical chemist with over twelve years of experience in the application of mass spectrometry for both quantitative and qualitative methods in food safety, clinical sciences, and environmental areas. She has dedicated her scientific career to biomarker discovery in human metabolomics, focusing on human nutrition, cardiovascular diseases, and the fascinating interplay between microbiome structure/function and the regulation of host physiology. Currently, she serves as the Product Manager for mzCloud and spectral libraries solutions</blockquote>

Thermo Fisher Scientific: Multiplex targeted metabolite panel development for the gut microbiome

Multiplex targeted metabolite panel development for the gut microbiome

Streamline targeted metabolite panel development for gut microbiome with multiplex LC-MSn methods using empirical databases to save time and costs.

Targeted Metabolite Panel Development for Gut Microbiome

Join our upcoming webinar to explore the innovative approach of Multi-Attribute Monitoring (MAM) for mRNA medicines using online partial RNase T1 digest and LC-MS. Mark Dickman from the University of Sheffield showcases a novel workflow to enhance the precision and efficiency of mRNA analysis.Learn about the methodology, applications and benefits of mRNA attribute monitoring with LC-MS and the use of novel software additions with Thermo Scientific™ BioPharma Finder™ software.Don't miss this opportunity to stay ahead in the rapidly evolving field of mRNA therapeutics.<h5>Key Learning Objectives:</h5><ul><li>Understand the principles and methodology of Multi-Attribute Monitoring (MAM) for mRNA medicines using online partial RNase T1 digest and LC-MS.</li><li>Learn how to apply RNase T1 digest and LC-MS techniques to enhance precision and efficiency in mRNA medicine analysis.</li><li>Gain insights into the benefits of MAM for ensuring better quality control and regulatory compliance in the development and production of mRNA therapeutics.</li></ul><h5>Who Should Attend:</h5><ul><li>Laboratory managers</li><li>Chromatography and mass spectrometry scientists</li><li>mRNA researchers</li><li>Biologics production scientists</li><li>QC analysts</li></ul><blockquote>Presenter: Mark J. Dickman (Professor, University of Sheffield)Presenter:&nbsp;Alexandra Taylor (Contributing Editor, C&amp;EN Media Group)</blockquote>

C&EN: Multi-Attribute Monitoring of mRNA Medicines Using Online Partial RNase T1 digest and LC-MS

Multi-Attribute Monitoring of mRNA Medicines Using Online Partial RNase T1 digest and LC-MS

Join webinar to explore innovative approach of Multi-Attribute Monitoring (MAM) for mRNA medicines using online partial RNase T1 digest and LC-MS.

Multi-Attribute Monitoring of mRNA by LC-MS & RNase T1

<h4>Part 1: Understanding the difference between single and triple quadrupole mass spectrometry</h4>Are you evaluating your next LC-MS investment or wondering which system best fits your workflows? Join the webinar with Aidan Harrison and gain clarity on the capabilities of single quadrupole (SQ), triple quadrupole (TQ), and QTRAP® mass spectrometers.In this session, we break down the fundamentals of mass spectrometry and dive into scan modes such as SIM, MRM, and MRM³. You’ll also discover how the hybrid power of QTRAP technology helps you go beyond quantification—offering qualitative confidence in even the most complex samples. Whether you're handling routine analyses or pushing detection limits in trace-level workflows, this webinar will help you make a confident, informed decision.<h5>What you’ll learn:</h5><ul><li>Key differences between SQ, TQ, and QTRAP platforms</li><li>How SIM, MRM, and MRM³ scan modes impact sensitivity and selectivity</li><li>When QTRAP technology adds value in method development and confirmation</li><li>Why QTRAP is ideal for analysts balancing quantitation with structural elucidation</li><li>Practical considerations based on matrix complexity, LOQ/LOD, and throughput</li></ul><blockquote>Presenter: Aidan Harrison (Senior Technical Specialist, SCIEX)With deep technical experience and a passion for simplifying the complex, Aidan helps labs unlock the full potential of their mass spectrometry systems.</blockquote>

SCIEX: Choosing the right MS: single quadrupole, triple quadrupole or QTRAP?

Understanding the difference between single and triple quadrupole mass spectrometry

Webinar on SQ vs TQ vs QTRAP LC-MS/MS. Explore SIM, MRM, and MRM³ fundamentals and learn how QTRAP boosts both quantitation and qualitative insight.

Difference between SQ and QQQ MS

<h4>Stop doing your calculations in Excel. Learn how to set up calculations in the Custom Calculator and Intelligent Reporter.</h4>&nbsp;Explore the differences between the two portions of software and understand where and when to use each. Customize individual injection reports. Explore how to create a sequence report with separate sections for standards and samples so statistics like average and standard deviation can be calculated across injections in a sequence.OpenLab CDS streamlines your lab operations with a single, secure data system that combines chromatography and mass spectrometry into one software platform. Control your Agilent GC, LC, single quadrupole GC/MS, LC/MS instruments as well as other vendors’ instruments in the lab, and save substantial time managing software and training staff. New tools in OpenLab CDS provide time-saving steps in the analysis, interpretation, and reporting workflows, so you can identify key information and improve turnaround time. Optional built-in technical controls provide peace of mind for analytical labs that need the highest level of data integrity.Agilent is offering our valued customers an opportunity to increase their knowledge of OpenLab CDS in a series of live / interactive webinars. Each participant will have their own virtual image with the software loaded, configured and accessed through the web in the safety of your socially distant location. The Agilent expert will lead this virtual seminar and walk participants through a series of interactive laboratories that will allow each attendee to USE the software instead of just view a demonstration. A series of three different sessions each 2 hours in length will be offered. Each will be focused on a different aspect of the software. Feel free to attend all or just one of these seminars.<blockquote>Presenter: Richard Mutkoski (Laboratory Informatics Application Engineer, Agilent Technologies, Inc.)Richard Mutkoski has been a field representative for over 27 years for both hardware and software. In his current role as an informatics application engineer, Rich presents technical solutions of the OpenLab suite of products to customers worldwide. Prior to his tenure at Agilent Rich spent 15 years in a variety of pharma QA/QC and R&amp;D positions, providing him a unique understanding of those workflows, bottlenecks, and challenges.</blockquote>

Agilent: OpenLab CDS Seminars - Remote Sessions

Seminar 3 – OpenLab CDS – Custom Calculator and Reporting

Learn how to set up calculations in the Custom Calculator and Intelligent Reporter.

OpenLab CDS – Custom Calculator and Reporting

Transferring analytical methods between laboratories is essential in regulated industries, but often deceptively complex. Although reproducibility should be straightforward in theory, inconsistencies in execution across labs can result in unreliable data, potentially triggering false positives or negatives. These missteps pose serious risks: from product recalls and delayed approvals to regulatory citations and costly batch rejections.<h5>In this webinar, we'll discuss:</h5><ul><li>Comparative testing as a proven strategy for assessing method transfer success, examine its strengths and weaknesses</li><li>The importance of continuous monitoring for long-term robustness and data integrity</li><li>Innovative digital tools that can simplify and accelerate both method transfer and post-transfer monitoring</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.Presenter:&nbsp;Zoe Chung (Principal Product Marketing Manager, Waters Corporation)Zoe Chung is a Product Marketing Manager at Waters, where she specializes in Empower Software Solutions. With over eight years of experience in marketing—and the last four focused on cloud-native technologies in the life sciences sector—Zoe brings a deep understanding of how digital innovation can transform scientific workflows. Her passion lies in advancing the next generation of software tools that enhance scientific productivity, unlock new ways to utilize data, and accelerate scientific discovery. At Waters, Zoe plays a key role in communicating the evolving capabilities of the Empower portfolio. She helps customers understand how to leverage cloud applications to gain faster, deeper insights from their chromatography data. Zoe is a dynamic advocate for modernizing lab informatics and is dedicated to helping organizations harness the full potential of their data through smarter, more connected solutions.</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About Data-Driven Approaches to Minimize Risk and Promote Data Quality

Empower Tips: Ask Me Anything About Data-Driven Approaches to Minimize Risk and Promote Data Quality

Streamline method transfer with comparative testing, monitoring and Empower software—cut errors and protect data integrity. Live Q&A with Waters experts.

Empower Tips Data-Driven Approaches to Minimize Risk

<div>The accurate, precise and reproducible measurement of amino acids is critical in the detection and monitoring of inherited metabolic disorders such as PKU, MSUD, UCDs etc. Waters' Kairos Amino Acid offers mass spectrometry based detection that is accurate, precise and enables the quantification of 40+ amino acids.&nbsp;In this webinar, Marijn Van Hulle from Waters will provide an overview of the existing Kairos Amino Acid kit as well as a preview of upcoming optimziations to the kit's method. Additionally, Kiara Theron from McMaster Children's Hospital will present the outcome of her validation studies of the Kairos Amino Acid Kit in plasma, urine &amp; CSF patient samples.<h4>Learning points:</h4><ul><li>Description of the kit &amp; overview of the AccQTag derivatization chemistry</li><li>Advantages of the status quo Kairos Amino Acid Kit&nbsp;</li><li>Overview of the optimization changes for the Kairos Amino Acid Kit</li><li>Validation of the Kairos Amino Acid kit in plasma at McMaster Children's Hospital</li></ul><h4>Who should attend:</h4><ul><li>Lab Scientists/Managers/Directors in General Hospitals or Children Hospitals and Reference Labs interested in developing and validating an LDT for Amino Acid analysis for routine clinical care&nbsp;</li></ul><blockquote>Presenter: Kiara Theron (Research Assistant &amp; Master's student at McMaster University Pathology &amp; Molecular Medicine, McMaster Children's Hospital)Kiara Theron is a second year Master’s student in McMaster’s Medical Sciences graduate program. She is currently working under Dr. Murray Potter at McMaster Children’s Hospital to optimize and validate LC-MS/MS methods for biochemical monitoring in patients with inherited metabolic disorders. Her more recent work has focussed on amino acid analysis for these patients as part of which she optimized and validated the Kairos Amino Acid kit for plasma, and urine, and CSF samples against the lab's predecessor method which was based on the MassTrak Amino Acid Kit.Presenter: Marijn Van Hulle (Global Director for Clinical Applications &amp; Support, Water Corporation)Marijn Van Hulle is the Global Director for Clinical Applications &amp; Support. He oversees field applications, global escalations of chemistry, IVD kit and consumables support, method transfers, and the application notes pipeline in collaboration with R&amp;D. Marijn joined Waters in 2004 as an LC-MS application specialist in the Benelux after earning his PhD in analytical chemistry from Ghent University. He has (co)authored nine Waters application notes and four peer-reviewed papers.</blockquote></div>

Waters Corporation: Optimization and Validation of the Kairos Amino Acid Kit in a hospital laboratory

Optimization and Validation of the Kairos Amino Acid Kit in a hospital laboratory

In this webinar, Waters will provide overview of the existing Kairos Amino Acid kit as well as a preview of upcoming optimziations to the kit's method.

Kairos Amino Acid Kit in a hospital laboratory

Time is a critical resource in laboratory operations. However, challenges such as redundant sample data management, manual data handling and transferring of results as well as time-consuming approval processes are common in many labs.In our upcoming webinar on October 21, we will explore how digitalizing laboratory workflows address these issues head-on. Based on a best-practice example we will demonstrate how the ready-to-use interfaces of the 1LIMS Laboratory Information Management System, OMNIS Software, and some lab devices facilitate process optimization through seamless connectivity and integration. As we will demonstrate with our example workflow, time savings of more than one minute per analysis are feasible.In a Q&amp;A session at the end of this webinar, we will be happy to answer any questions you can have about digitalizing laboratory workflows. Don’t miss this opportunity and learn more about how to make your routine analysis more efficient.<h4>Key takeaways of this webinar:</h4><ul><li>Understand why connectivity is key to integrating your laboratory operations</li><li>Understand how seamless integration enables better planning and resource management</li><li>How to maximize efficiency of your laboratory operations</li><li>How to transform your laboratory into a fully integrated, digital ecosystem&nbsp;</li></ul><h4>Who should attend?</h4><ul><li>Laboratory managers, IT managers, and anyone interested in making their laboratory processes more efficient.</li></ul><blockquote>Presenter: Simon Böhm, PhD (Head of Comptence Center Software, Metrohm International Headquarters)Simon Böhm is Head of Competence Center Software at Metrohm International Headquarters in Herisau, Switzerland. He joined Metrohm Germany in 2017 as Product Specialist for titration. After being involved in rolling out OMNIS at customer sites in Germany, he took the opportunity to become global Product Manager at Metrohm International Headquarters and bring in his extensive experience. Simon studied chemistry at the University of Constance and earned his PhD from the ETH Zurich in physical chemistry.Presenter: Philipp Osterwalder (Co-founder and CEO, 1LIMS Lab and Quality Solution)Philipp Osterwalder is a skilled laboratory technician with further expertise as a biomedical analyst. While studying to become an environmental engineer specialising in eco-technology and ecological analytics, he founded 1LIMS as co-founder and current CEO to digitalize laboratories with a simple, flexible, smart solution. Today, 1LIMS is an international competence centre in lab process optimisation, laboratory digitalisation and automation, focusing on holistic expertise using lean Six Sigma.</blockquote>

Metrohm: Time is money - how digitalized workflows enhance laboratory efficiency

Time is money - how digitalized workflows enhance laboratory efficiency

Discover how OMNIS and 1LIMS integration boosts lab efficiency, saves time, and enables full digital connectivity.

How digitalized workflows enhance laboratory efficiency

<div>In the race of accelerated drug discovery, the integration of artificial intelligence (AI) and machine learning (ML) with advanced screening technologies is transforming the way we identify hits. Join us for an insightful session exploring how AI/ML-driven enrichment is improving efficiency of affinity selection mass spectrometry (ASMS) approach in terms of timelines and costs.This webinar will showcase how cutting-edge computational approaches are being applied to ASMS screening workflows to accelerate hit identification, uncovering novel binders with greater precision. Our expert speakers will walk through real-world applications, share performance metrics and discuss how these innovations can help re-shape early-stage discovery.Whether you're a scientist, data analyst or decision-maker in biotech or pharma, this session will provide actionable insights into harnessing AI/ML for smarter, faster and highly confident hit discovery.<h4>Attend this webinar to:</h4><ul><li>Understand how AI/ML technologies are integrated into ASMS workflows</li><li>Evaluate the impact of AI/ML-driven enrichment on screening efficiency</li><li>Gain knowledge of real-world application of AI/ML in hit discovery</li></ul><blockquote>Presenter: Ghislaine Marchand (Group Leader Biophysics, Evotec)Ghislaine Marchand leads the biophysics group at Evotec Toulouse, bringing over 25 years of expertise in the pharmaceutical industry. She began her career at Sanofi, where she held various R&amp;D positions spanning pharmacokinetics, anti-infective research and high-throughput screening.Presenter: Benedikt Bauer (Group Leader In Silico R&amp;D at Evotec)Benedikt Bauer leads a multidisciplinary data science group at Evotec Hamburg, driving the design and implementation of advanced analytics and machine learning models integrated into operational workflows. Since joining Evotec close to a decade ago, Benedikt has shaped various data related aspects of the company, from data management over data engineering to data science. His primary focus is on coordinating closely with biologists to identify scientific challenges where data science can deliver meaningful impact – bridging experimental insights with computational innovation.</blockquote></div>

Technology Networks: Changing the Landscape of Screening: AI-Powered ASMS Ligand Identification

Changing the Landscape of Screening: AI-Powered ASMS Ligand Identification

Discover how AI/ML-driven enrichment enhances ASMS screening efficiency and precision in hit discovery.

Related content

News from LabRulezLCMS Library - Week 16, 2026

Two-Dimensional Liquid Chromatography Isolation and Quantitation of IgG and Exosomes from Cell Culture Media (Chris Topper, MDCW 2026)

Seasonal update on liquid handling