Ultrashort chain per- and polyfluoroalkyl substances (USC-PFAS),defined as those with three or fewer carbon atoms, are characterisedby their significant mobility within the environment, high water solubility,and low affinity for organic matter. These properties contributeto their widespread presence in environmental waters and wastewaters,as well as drinking waters. The environmental concerns associatedwith USC-PFAS include their persistence, potential for groundwatercontamination, and challenges in remediation due to their resistance to conventional treatment methods.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_Czech_Republic_Enviromail_29_Unstoppable_Ultrashort_PFAS_in_the_environment_and_water_sources_2_093d51b263.jpg" alt="EnviroMail™29/Europe: Unstoppable? Ultrashort PFAS in the environment and water sources: Figure 1: Illustrative picture" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_Czech_Republic_Enviromail_29_Unstoppable_Ultrashort_PFAS_in_the_environment_and_water_sources_2_093d51b263.jpg 245w," sizes="100vw" width="602" height="247"><h4>Occurence, uses and sources</h4>Ultrashort chain PFAS have been poorly characterised compared with their longer chain counterparts, and understanding of their intended and unintended transformation processes is limited. Sources of USCPFAS include degradation of precursor compounds, atmospheric degradation of hydrofluorocarbons and hydrochlorofluorocarbons used as refrigerants, and intentional direct use in products like batteries. Crucially, TFA, a major ultrashort-chain PFAS, is also formed through the environmental breakdown of fluorinated pesticides and pharmaceuticals. They are also byproducts from historical electrochemical fluorination (ECF) manufacture of longer chain PFAS. USC-PFAS are also found in urban and industrial waste, as well as aqueous film-forming foams (AFFFs) used in firefighting.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_Czech_Republic_Enviromail_29_Unstoppable_Ultrashort_PFAS_in_the_environment_and_water_sources_5698c634d6.jpg" alt="EnviroMail™29/Europe: Unstoppable? Ultrashort PFAS in the environment and water sources: Figure 2: PFSA and PFCA categorization based on carbon chain length – ultrashort-chain, short-chain and long-chain." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_Czech_Republic_Enviromail_29_Unstoppable_Ultrashort_PFAS_in_the_environment_and_water_sources_5698c634d6.jpg 245w," sizes="100vw" width="1496" height="629"><h4>Fate and transport</h4>Carbon chain length plays a key role in determining the physicochemical characteristics of different PFAS chemicals. Long chain PFAS for instance are more hydrophobic, a property that has been leveraged by removal techniques using carbonaceous materials like granular activated carbon (GAC). By contrast, short and ultrashort chain PFAS are hydrophilic, with characteristically low pKa values (i.e. more acidic), high water solubilities and decreased log Koc values (i.e. less adsorptive to organic carbon). These attributes mean that USC-PFAS dissociate freely in aqueous environments and are less prone to sorption onto natural solids. The outcome is that USCPFAS are highly mobile in the aquatic environment and can travel far from contamination source areas.<h4>The global regulatory landscape</h4>Awareness about the persistence and bioaccumulative nature of C8-C14 PFAS began to attract widespread concern near the turn of the millennium, and inclusion of PFOS, PFOA and PFHxS on the persistent organic pollutants (POPs) list of the Stockholm Convention soon ensued. Consequentially, manufacturers began adopting short and ultrashort chain alternatives.However, with the change from C8 to C4 and shorter fluorinated carbon chains came the sacrifice to lower technical performance, and greater quantities were needed for equivalent performance. Hence, while it is generally accepted that short and ultrashort chain PFAS have lower toxicological profiles, environmental risks are not necessarily obviated since USC-PFAS presence, and continuous, cumulative, release suggests that adverse risks may lie ahead.Global regulations of USC-PFAS vary by region and are often included under broader PFAS regulations. For example, the European Union has specific guidelines and limits for the total concentration of PFAS compounds in drinking water (as set out in EU Directive 2020/2184). The EU's Drinking Water Directive established a limit of 0.5 μg/L for 'PFAS Total,' although ongoing discussions concern the specific methodology for incorporating trifluoroacetic acid (TFA). Furthermore, TFA was recently added to the priority list for the initial proposed sum of 24 PFAS in surface water. <a target="_blank" rel="noopener noreferrer" href="https://www.consilium.europa.eu/en/press/press-releases/2025/09/23/water-pollution-council-and-parliament-reach-provisional-deal-to-update-priority-substances-in-surface-and-ground-waters/">LINK</a><h4>PFAS sampling containers</h4>Only tested and verified sampling containers are recommended to ensure reliable results in PFAS analysis; these containers are available upon request from ALS laboratories.<h4>Targeted analytical services are becoming more accessible</h4>Testing for USC-PFAS is challenging due to several analytical factors. Background contamination and matrix noise can interfere with the detection of these compounds, particularly trifluoroacetic acid (TFA). Furthermore, sample preparation presents a significant challenge because of the constant risk of cross-contamination. To mitigate this risk, the sample preparation procedure was specifically designed to be as simple and straightforward as possible.Other USC-PFAS compounds generally have lower ambient background concentrations, which makes achieving lower Limits of Reporting (LOR) more readily achievable. ALS has successfully developed a testing method that includes USC-PFAS compounds in environmental water matrices, achieving a total LOR of 50 ng/L for TFA and even lower LORs for other USC compounds. The full list of analyzed USC-PFAS is summarized in table 1:<h5>USC-PFAS Compounds / CAS No.</h5><ul><li>Trifluoroacetic acid (TFA), Perfluoroethanoic acid (PFEtA): 76-05-1</li><li>Trifluoromethane sulfonic acid (TFMS), Perfluoromethane sulfonic acid (PFMeS): 1493-13-6</li><li>Perfluoroethane sulfonic acid (PFEtS): 354-88-1</li><li>Perfluoropropanoic acid (PFPrA): 422-64-0</li><li>Perfluoropropane sulfonic acid (PFPrS): 423-41-6</li><li>Trifluoromethane sulfinic acid: 34642-42-7</li><li>Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI): 90076-65-6</li></ul>&nbsp;

EnviroMail™29/Europe: Unstoppable? Ultrashort PFAS in the environment and water sources

<h4>Why Consider HILIC in Modern Oligonucleotide Analysis?</h4>Oligonucleotides play a central role in gene therapies, molecular diagnostics, and cutting-edge biomedical research. Before these molecules reach application, however, they must be carefully characterized to confirm purity, identity, and performance.Analyzing therapeutic oligonucleotides is far from straightforward. Their polarity, structural diversity, and modifications demand highly selective and MS-compatible separation methods. Although ion-pair reversed-phase LC (IP-RP-LC) remains the established standard for LC-MS workflows, hydrophilic interaction liquid chromatography (HILIC) is rapidly emerging as a powerful complementary technique.When IP-RP approaches reach practical or performance limits, HILIC offers an attractive alternative, delivering strong retention and efficient separation of highly polar oligonucleotides — without relying on ion-pairing reagents.<h4>How Does HILIC Separate Oligonucleotides?</h4>HILIC essentially reverses conventional reversed-phase logic. It combines:<ul><li>A polar stationary phase</li><li>An organic-rich mobile phase</li></ul>In this configuration, the stationary phase retains a thin, water-enriched layer on its surface. Polar analytes — such as oligonucleotides — partition into this aqueous layer while the acetonitrile-rich mobile phase passes through.This mechanism allows:<ul><li>Retention of short or highly polar oligonucleotides</li><li>Separation of modified sequences</li><li>LC-MS compatibility without ion-pairing reagents</li></ul>The key to performance lies in carefully tuning the parameters that govern HILIC selectivity and retention.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_Key_Parameter_of_HILIC_Mode_fb364c9a8b.webp" alt="KNAUER: Figure 1 - Key Parameter of HILIC Mode." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_Key_Parameter_of_HILIC_Mode_fb364c9a8b.webp 245w," sizes="100vw" width="945" height="433"><h4>What Controls Retention in HILIC?</h4>Several interaction mechanisms contribute to analyte behavior in HILIC:<h5>Hydrophilic Partitioning – The Primary Mechanism</h5>Polar molecules distribute into the thin water layer formed on the stationary phase surface. The greater the polarity of the analyte, the stronger its affinity for this layer, leading to increased retention.<h5>Hydrogen Bonding – Fine-Tuning Effects</h5>Functional groups such as –OH, –NH₂, and –COOH can form hydrogen bonds with the stationary phase, subtly influencing retention time and selectivity.<h5>Electrostatic Contributions – The Role of Charge</h5>Some HILIC materials (e.g., bare silica) exhibit surface charges. Depending on mobile phase pH and buffer composition, electrostatic interactions can either enhance or suppress analyte retention.<h5>Dipole and Ion–Dipole Interactions – Added Selectivity</h5>Highly polar or zwitterionic compounds — including phosphorylated species and sugars — may engage in dipole–dipole or ion–dipole interactions, further refining separation behavior.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Hydrophilic_Partitioning_on_Water_enriched_Layer_41ab9ac902.webp" alt="KNAUER: Figure 2 - Hydrophilic Partitioning on Water-enriched Layer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Hydrophilic_Partitioning_on_Water_enriched_Layer_41ab9ac902.webp 245w," sizes="100vw" width="945" height="409"><h4>How to Develop a HILIC Method for Oligonucleotides</h4>Like any chromatographic method, successful HILIC development follows a structured approach:<h5>Step 1: Define the Analytes</h5>Understand oligonucleotide length, polarity, charge, and modifications.<h5>Step 2: Select a Suitable Column</h5>Choose a polar stationary phase (e.g., amide or zwitterionic) appropriate for the oligonucleotide’s chemical properties.<h5>Step 3: Optimize the Mobile Phase</h5><ul><li>Start with 70–95% acetonitrile</li><li>Use a volatile buffer (e.g., ammonium formate or ammonium acetate, typically 5–20 mM)</li><li>Adjust pH (commonly between 6–8, with testing up to pH 9 if column stability allows)</li></ul>Small pH shifts can significantly alter selectivity and MS response.<h5>Step 4: Design the Gradient</h5>Employ a gradient that increases water content to modulate retention and separate oligonucleotides by size or chemical modification.<h5>Step 5: Match Injection Conditions</h5>Samples should be injected in a solvent similar to the starting mobile phase (high organic content) to prevent peak distortion.<h5>Step 6: Evaluate Performance</h5>Assess:<ul><li>Resolution</li><li>Retention time stability</li><li>Peak shape</li><li>Reproducibility</li></ul>Balancing separation performance with MS ionization efficiency is essential.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Table_1_HILIC_Method_Step_Procedure_for_Oligos_f3b9ea6b08.webp" alt="KNAUER: Table 1 - HILIC Method Step Procedure for Oligos." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Table_1_HILIC_Method_Step_Procedure_for_Oligos_f3b9ea6b08.webp 245w," sizes="100vw" width="945" height="357"><h4>Practical Tips for High-Performance HILIC</h4><h5>Maintain a Stable Water Layer</h5>A minimum of ~5% water is necessary at the start of the run. Too little water can eliminate retention entirely. Adjust water content carefully to fine-tune retention.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_Water_Adjustment_Principle_for_HILIC_c0d8616f20.webp" alt="KNAUER: Figure 3 - Water Adjustment Principle for HILIC." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_Water_Adjustment_Principle_for_HILIC_c0d8616f20.webp 245w," sizes="100vw" width="951" height="374"><h5>Use High Organic Content</h5>HILIC typically operates best with 70–95% acetonitrile. Polar analytes are retained more effectively under these conditions.<h5>Include a Volatile Buffer</h5>Use low concentrations (5–20 mM) of ammonium formate or acetate to:<ul><li>Stabilize pH</li><li>Reduce peak tailing</li><li>Maintain MS compatibility</li></ul><h5>Control Injection Solvent</h5>Avoid high-water sample solvents. They disrupt the partitioning mechanism and distort peaks.<h5>Allow Proper Column Equilibration</h5>HILIC columns require longer equilibration times than reversed-phase columns — typically 10–20 column volumes after major gradient or solvent changes.<h5>Consider Temperature</h5>Operating at 30–50 °C can:<ul><li>Improve peak shape</li><li>Reduce mobile phase viscosity</li><li>Stabilize retention behavior</li></ul><h4>From Alternative to Essential? Final Perspective</h4>HILIC-MS is steadily advancing as a strong, ion-pair-free option for oligonucleotide analysis. While IP-RP-LC still dominates in sensitivity for many applications, HILIC is closing the gap and offering valuable flexibility — particularly for highly polar or challenging sequences.Although HILIC follows different chromatographic principles than reversed-phase separations, once optimized, it can deliver robust and highly selective results.Rather than being a niche method, HILIC is becoming a strategic tool in modern oligonucleotide workflows — especially when MS compatibility and method versatility are priorities.If you are developing or refining an oligonucleotide LC-MS method, HILIC may be worth integrating into your analytical toolbox.<blockquote>For additional information or discussion, feel free to contact: <a>sales@knauer.net<svg><use></use></svg></a>For direct scientific inquiries, reach out to the author at: <a>kindler@knauer.net<svg><use></use></svg></a></blockquote>Stay tuned for more insights in the “Oligos Made Easy” series.

Oligos Made Easy - Part 4: HILIC

News from LabRulezLCMS Library - Week 09, 2026

Article

Application

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For more than 40 years, ALS has provided testing and technical solutions to clients all over the world in a wide range of industries. We have built our global reputation by embracing the latest technologies and innovative methodologies to deliver high quality testing services to clients. ALS is able to leverage a multifaceted international team while remaining agile enough to provide local expertise and personalized solutions to every one of our clients.

ALS Czech Republic

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

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Waters Corporation

By attending this presentation, you will learn how to:
<ul>
<li>Improve PFAS analysis in biological samples with a simple yet effective novel sample prep technique</li>
<li>Achieve cleaner extracts for a wide range of PFAS compounds without compromising recovery</li>
<li>Implement an automated, robust, and reproducible sample prep method for PFAS analysis in biological samples with the Extrahera™ Sample Prep Workstation</li>
</ul>
Event Overview
PFAS analysis in biological samples can be quite challenging due to the complexity of sample matrices and the wide range of compound classes, each with different chemical characteristics. The ubiquitous nature of these compounds further complicates the sample preparation process.
In this webinar, Adam Senior from Biotage and Joe Homan from NMS Labs will present a novel sample prep method using the ISOLUTE® PLD+ for PFAS that overcomes some of these challenges. They will compare this method’s efficiency and effectiveness to other available techniques, illustrating how to achieve cleaner extracts for a wide range of PFAS compounds. Lastly, they will demonstrate how to automate sample preparation for PFAS analysis to achieve better reproducibility and enhance productivity.
What you need to know:
Date: 25 June, 2024
Start times:
Broadcast #1: 25 June - 7:30 am IST (New Delhi) / 10 am SGT (Singapore) / 10 am CST (Beijing) / 11 am JST (Tokyo) / 12 pm AEST (Melbourne) / 2 pm NZST (Auckland)
Broadcast #2: 25 June - 10 am BST (London) / 11 am CEST (Paris/Berlin) / 2:30 pm IST (New Delhi) / 5 pm SGT (Singapore)
Broadcast #3: 25 June - 10 am PDT (Los Angeles) / 12 pm CDT (Chicago) / 1 pm EDT (New York)
<blockquote>
Presenter: Adam Senior (Senior R&amp;D Analytical Scientist, Biotage)
</blockquote>
<blockquote>
Adam is an analytical chemist with more than 20 years of experience in method development in diverse applications. He is a Senior Scientist in the Research and Development group at Biotage. Adam is involved in the development and validation of LC-MS/MS sample preparation assays. His recent work has focused on the analysis of PFAS compounds in biological matrices, which led to the development of a new sample prep solution for this application.
</blockquote>
<blockquote>
Joseph Homan (Principal R&amp;D Scientist II, NMS Labs)
</blockquote>
<blockquote>
Joseph Homan is Principal R&amp;D Scientist II at NMS Labs in Horsham, Pennsylvania. He leads clinical and forensic analytical test development and validation. He explores, recommends, and implements scientific innovations, and optimizes current instrumentation and methodologies to improve quality, efficiency, profitability, and service.
</blockquote>

Separation Science: Overcoming Sample Prep Challenges with PFAS Analysis in Biological Fluids

Overcoming Sample Prep Challenges with PFAS Analysis in Biological Fluids

Discover a novel sample prep method to achieve cleaner extracts for a wide range of PFAS compounds.

Sample Prep for PFAS Analysis in Biological Fluids

Size, Polydispersity, Particle concentration and Zeta potential are crucial parameters for understanding the quality of LNP samples. The DynaPro ZetaStar instrument obtains all this critical quality attributes for you in mere seconds which makes it the perfect analytical equipment for evaluating LNP characteristics. In this webinar, we will showcase how the ZetaStar instrument can be utilized in Research and Development for better understanding how formulation, solvent conditions, storage, and stress can alter the properties of LNP.

Waters Corporation: Enhanced LNP quality assessment during Research and Development by DLS/SLS/ELS with the DynaPro ZetaStar Instrument

Enhanced LNP quality assessment during Research and Development by DLS/SLS/ELS with the DynaPro ZetaStar Instrument

LNP assessment by DLS/SLS/ELS with DynaPro ZetaStar

To advance research for precision oncology, it is essential to identify molecular changes that underly tumorigenesis.
Now you can tailor tumor genomic profiling assays by customizing next-generation sequencing (NGS) cancer panels to fit your laboratory’s specific requirements, including the assessment of new and emerging biomarkers, the immuno-oncology biomarkers (tumor mutational burden (TMB) and microsatellite instability (MSI)), and homologous recombination deficiency (HRD).
Agilent SureDesign, a user-friendly panel design software powered by machine learning, offers fast and easy design of Agilent SureSelect Cancer Custom panels to enable detection of key classes of somatic alterations. 
In this webinar, you will learn about:
<ul>
<li>The range of available tumor genomic profiling assays (comprehensive, tumor-specific, customized) in the Agilent SureSelect Cancer product portfolio</li>
<li>Designing customized cancer panels with SureDesign, by leveraging globally curated, cancer-specific genes and curating your own gene list</li>
<li>Achieving high-quality results from samples such as formalin-fixed, paraffin-embedded (FFPE) tissues </li>
<li>Improving lab efficiency by streamlining library preparation and target enrichment with automation, reducing hands-on time to as little as 15 minutes </li>
<li>Integrated workflows incorporating NGS sample and library QC, compatibility across multiple sequencing platforms, and informatics options</li>
</ul>
<blockquote>
Presenter: Danielle Fletcher (Field Applications Scientist, Agilent Technologies)
</blockquote>
<blockquote>
Danielle is a member of Agilent’s European custom design service. This team assists customers by creating custom NGS target enrichment panels as well as CGH and GE microarrays designs.
</blockquote>
<blockquote>
Presenter: Michael Ruvolo, Ph.D. (Director, R&amp;D, Agilent Technologies)
</blockquote>
<blockquote>
Mike is the director of NGS content development at Agilent Technologies.
</blockquote>
<blockquote>
He and his team are responsible for assay development using SureSelect NGS target enrichment technology.
</blockquote>

Agilent: Democratizing Tumor Genomic Profiling With Tailored Content

Democratizing Tumor Genomic Profiling With Tailored Content

Agilent SureDesign, a panel design software powered by machine learning, offers fast and easy design of Agilent SureSelect Cancer Custom panels.

Tumor Genomic Profiling With Tailored Content

Analyzing low-level analytes in complex biological matrices while maintaining superior sensitivity over the length of the study is a challenge for many researchers. Thus, triple quadrupole mass spectrometers are widely used in quantitative bioanalysis for their accuracy and precise measurement of pharmaceutical drugs in these complex matrices.
In this presentation, our speaker will introduce technology advancements that help ensure the highest levels of performance are maintained. He will share data that demonstrates how triple quadrupole mass spectrometers provide not only exceptional sensitivity but additional stability to support challenging bioanalytical workflows.
Attend this webinar to discover:
<ul>
<li>Technology innovations to support robust long-term bioanalysis</li>
<li>Best practices to achieve accurate and precise measurements by LC-MS in bioanalysis</li>
<li>How to preserve long-term method sensitivity in complex matrices</li>
</ul>
<blockquote>
Presenter: Rahul Baghla (Manager, Global Scientific Marketing, SCIEX)
</blockquote>

Technology Networks: Ensure Accuracy and Precision in Pharmaceutical Bioanalysis

Ensure Accuracy and Precision in Pharmaceutical Bioanalysis

Triple quadrupole mass spectrometers provide exceptional sensitivity and additional stability to support challenging bioanalytical workflows.

Accuracy and Precision in Pharmaceutical Bioanalysis

ZONTAL and Mestrelab by SciY are leaders in their respective areas of data digitalisation and complex analytical data processing. In this talk we explore how the two products can be seamlessly integrated to add convenience and value. Specifically, we look at how ZONTAL can harness the power of Mnova automated structure verification on data ingestion, and also how end users can use the familiar Mnova desktop application to directly search, access and save to the ZONTAL platform via Mnova Hub. These integrations enhance both products and enable them to be used with even greater efficiency when dealing with complex analytical data like NMR or LCMS.
Agenda
<ul>
<li>An introduction to Sciy</li>
<li>Getting value from scientific data – FAIR data</li>
<li>Getting value from scientific data – getting information and learning from complex data</li>
<li>Examples of seamless integration</li>
<li>Ingestion processing for automated structure elucidation</li>
<li>Ad hoc processing by users in a favoured desktop application</li>
</ul>
Key Learning Points
<ul>
<li>Why a FAIR data platform is important</li>
<li>How we can connect a FAIR data platform to end user applications to solve real laboratory problems</li>
</ul>
<blockquote>
Presenter: Dr. Christof Gaenzler (Director PreSales and Product Marketing)
</blockquote>
<blockquote>
Dr. Gaenzler holds a Doctorate in Molecular Biology from the University of Heidelberg and contributed to the development of the first HPV vaccines during his time at the German Cancer Center in Heidelberg. During his career outside of academia Dr. Gaenzler served as Senior Consultant and PreSales Manager at TIBCO Spotfire, and as the Senior Principal Product Marketing Manager for Biology at PerkinElmer Informatics. Currently, Dr. Gaenzler brings his expertise to ZONTAL as the Director of PreSales and Product Marketing.
</blockquote>
<blockquote>
Presenter: Gary Sharman, PhD (Senior Scientific Director)
</blockquote>
<blockquote>
Gary studied Natural sciences at the University of Cambridge before completing a PhD with prof Dudley Williams on structural and mechanistic studies by NMR and MS. He spent 20 years in the pharmaceutical industry, working in analytical chemistry at AstraZeneca and Eli Lilly, where he developed a particular interest in data flows and visualisations. He moved to Mestrelab in 2020, where his role centres around automation, data processing and customisation.
</blockquote>

Mestrelab Research: SciY Mestrelab Mnova & ZONTAL Join Forces for Next-Level Data Integration

SciY Mestrelab Mnova & ZONTAL Join Forces for Next-Level Data Integration

In this talk we explore how the two products can be seamlessly integrated to add convenience and value.

SciY Mestrelab Mnova & ZONTAL Data Integration

Together with ALS Czech Republic, we bring you an exclusive webinar series offering insights into the world of per- and polyfluoroalkyl substances (PFAS). The three-part series will bring together regulatory experts from REGARTIS and environmental laboratories professionals of ALS Czech Republic to address PFAS from environmental risks to the evolving regulatory landscape and analytical challenges.
First, we will explore their uses, environmental hazards, and restriction efforts. The second part will be focused on analytics, helping attendees understand PFAS testing in various matrices and the implications of their widespread environmental presence. Finally, the series will offer a discussion on regulatory processes, compliance strategies, and the technical aspects of PFAS analysis, such as sampling rules and possible matrices types. The core aim of the series is to provide chemical industry stakeholders with the knowledge to effectively manage PFAS compliance and analysis both.
<h3>Compliance and technical readiness</h3>
<ul>
<li>Ing. Jana Trávníčková, Ph.D.</li>
<li>Ing. Jana Kováčová, Ph.D.</li>
</ul>
In the final part of the series, co-hosted by REGARTIS and ALS Czech Republic, the focus will shift to the regulatory framework surrounding PFAS. This session will examine the background of PFAS restriction proposals, their reasonings, and the specific PFAS compounds involved.
Key topics will include the current status of PFAS restrictions and strategic preparation for forthcoming regulations, particularly regarding flame retardants. Additionally, ALS Czech Republic will introduce the technical aspects of PFAS analysis, including sample types and matrices, sampling rules, and logistical considerations when transporting samples for PFAS analyses. This part aims to equip attendees with the knowledge to navigate the evolving landscape of PFAS regulations and analytical methodologies.
<blockquote>
Presenter: Ing. Jana Trávníčková, Ph.D., (Regulatory Queen, Customer Happiness Manager – REGARTIS)
</blockquote>
<blockquote>
Jana studied chemistry at FCH VUT in Brno. She has been advising in the field of chemical European and national legislation since 2014. She can advise you on everything related to REACH, especially the authorization of SVHC substances, RoHS II, and the Regulation on Conflict Materials. She can also advise you on meeting the requirements of REACH in the area of safety data sheet management and CLP requirements.
</blockquote>
<blockquote>
Presenter: Ing. Jana Kováčová, Ph.D., (PFAS Section Supervisor – ALS Czech Republic)
</blockquote>
<blockquote>
Jana has been working in the field of analytical chemistry for more than 15 years. She defended her master&#39;s and doctoral studies at the University of Chemical Technology in Prague (UCT Prague), where her research focused on the development of analytical methods for determining pesticide residues in food and water. Jana joined ALS Czech Republic in the year 2020 as a validation specialist and focused her attention on optimising methods for the analysis of PFAS in environmental samples. At the beginning of 2022, she became the supervisor of the PFAS Section in Prague ALS Laboratories.
</blockquote>

ALS Czech Republic: PFAS: Strategic Approaches for Chemical Industry Compliance

PFAS: Strategic Approaches for Chemical Industry Compliance - Compliance and technical readiness

Examine the background of PFAS restriction proposals, their reasonings, and the specific PFAS compounds involved.

PFAS: Compliance and technical readiness

CVS (Cyclic Voltammetric Stripping) is the preferred method for monitoring the concentration of suppressors, brighteners, and levelers used in the production of high-quality printed circuit boards (PCBs) and in advanced packaging of semiconductors. Automating this monitoring can help manufacturers to significantly save time and effort while helping them to keep pace with increasing numbers of samples.
In her webinar, Barbara Zumbrägel, Product Manager Voltammetry at Metrohm International Headquarters, will present the latest technology to take fully automated quality control in PCB manufacturing with CVS to the next level of performance, efficiency, and convenience. Following the webinar, Barbara will be available for a Q&amp;A Session to answer any questions you may have.
Key learnings of this webinar:
<ul>
<li>How automated sample transfer and dosing can make your determination of suppressors, brighteners, and levelers more efficient</li>
<li>How to handle the increasing number of auxiliary solutions with an automated pipetting system</li>
<li>How to optimize your workflow by customizing methods in the viva software to meet the specific requirements of your analysis protocol</li>
</ul>
Who should attend?
<ul>
<li>Lab technicians and lab managers from the PCB, PWB, and semiconductor manufacturing industries</li>
</ul>
<blockquote>
Presenter: Barbara Zumbrägel (Product Manager Voltammetry, Metrohm International Headquarters)
</blockquote>
<blockquote>
Barbara Zumbrägel earned her diploma in chemistry from Technische Universität Clausthal, Germany, and joined Metrohm International Headquarters in 1999 as a product and application specialist for voltammetry. Since 2003, she has also played a significant role in the ongoing development of the Metrohm portfolio of CVS products and applications. In 2006, Barbara was promoted to Product Manager Voltammetry.
</blockquote>

Metrohm: Next level of CVS automation - how to increase the efficiency of your routine analysis

Next level of CVS automation - how to increase the efficiency of your routine analysis

Fully automated quality control in PCB manufacturing with CVS for the next level performance, efficiency, and convenience.

CVS automation - how to increase the efficiency

Embark on a transformative journey with Waters and Scitara in our upcoming webinar, where we illuminate the pathway to authentic digital evolution within laboratory environments. Together, we will navigate the critical landscape of connectivity, seamlessly integrating Waters technologies into the broader lab ecosystem through the innovative Scitara DLX platform.
Join us for an enriching discussion on the strategic advantages of platform integration over point-to-point solutions, the transformative capabilities of Scitara DLX as a robust data conduit within the Waters ecosystem, and the symbiotic relationship between FAIR data principles and AI in platform integration. Discover how this synergy empowers Waters and its customers to unlock unparalleled efficiency, innovation, and collaboration across laboratory workflows.
<blockquote>
Presenter: David Levy (Vice President of Strategy, Partnerships, Scitara)
</blockquote>
<blockquote>
David Levy has 30 years of product and global account management experience in strategic and domestic international software development, product/project management, and sales in the life science marketplace. He has introduced several game-changing products to market while working for Waters Corporation, NuGenesis Technologies Corp., CambridgeSoft Inc., and PerkinElmer Inc. He is currently the Head of Strategy and Partnerships at Scitara Corporation.
</blockquote>
<blockquote>
Presenter: Ben Dearnaley (Product Owner, Cloud Data Analytics, Waters Corporation)
</blockquote>
<blockquote>
Ben has worked at Waters for 17 years, and 14 years in Pharma prior to that.His area of interest as both a customer and at Waters has been on how to leverage Empower meta-data into analytics and Business Intelligence which helps Empower stakeholders understand better how their Laboratories are working, such as understanding system and resource utilisation, laboratory workflows and potential data integrity issues. Ben was a key individual involved with EDS365, and is now working as a Cloud Product Owner with a focus on bringing Empower analytics into the Cloud.
</blockquote>

Waters Corporation: Empowering Digital Transformation: Uniting Waters Technologies with the Lab Ecosystem via Scitara DLX

Empowering Digital Transformation: Uniting Waters Technologies with the Lab Ecosystem via Scitara DLX

Integrating Waters technologies into the broader lab ecosystem through the innovative Scitara DLX platform.

Uniting Waters Tech with Lab Ecosystem via Scitara DLX

UV-Vis spectroscopy is a well-established technique in many laboratories. For decades, laboratories have adapted to pain points associated with UV-Vis workflows such as daily instrument warm-up, yearly lamp replacement, and slow and cumbersome temperature control systems.
Dr. Mathieu Rault, Cary 3500 Product Manager for Agilent Technologies, will present the Agilent Cary 3500 UV-Vis spectrophotometer series, developed from the ground-up to address these pain points and go beyond traditional user experiences. The Cary 3500 UV-Vis solution is a modular system that offers laboratories several benefits such as scalability, flexibility, and cost efficiency, as well as high analytical performances when measuring liquid and solid samples.
Each module has been designed and optimized depending on the sample type and analytical objectives. The modular design and software remove the burden of performing optical alignment procedures and the time and effort to recalibrate the instrument each time a module is changed. Swapping modules is quick, simple, and easy, allowing users to address specific application needs with tailored UV-Vis solutions.
Dr. Rault will also highlight UV-Vis applications for liquid and solid samples to illustrate the benefits of the instrument’s modular design.
Key learning objectives
<ul>
<li>Explore the benefits of using a modular UV-Vis spectrophotometer system in a laboratory setting to gain flexibility and increase cost efficiency</li>
<li>Understand how modular UV-Vis spectroscopy can benefit liquid sample analysis, such as offering simultaneous measurement of up to seven samples, small volume measurement, and characterization of solid samples.</li>
<li>Discover how the Cary 3500 smart modular design solution will help laboratories to achieve more, while reducing traditional UV-Vis spectroscopy pain points</li>
</ul>
Who should attend?
<ul>
<li>Pharma/biopharma QA/QC laboratory analysts and laboratory managers.</li>
<li>Chemical and energy laboratory analysists and laboratory managers.</li>
<li>Academia – PhD/ Post doctoral / Principal investigators.</li>
</ul>
Three sessions available
<ul>
<li>Thursday 27th June 2024 / 09:00 EDT / 14:00 BST / 15:00 CEST</li>
<li>Thursday 27th June 2024 / 12:00 PDT / 14:00 CDT / 15:00 EDT</li>
<li>Friday 28th June 2024 / 08:30 IST / 12:00 JST / 13:00 AEST</li>
</ul>
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
<blockquote>
Presenter: Mathieu Rault (Global Cary 3500 Product Manager, Agilent Technologies, Australia)
</blockquote>
<blockquote>
Presenter: Carrie Haslam (Associate Editor, SelectScience)
</blockquote>

SelectScience: Modular UV-Vis Spectroscopy: A Smart and Scalable Approach to High-Performance Analysis

Modular UV-Vis Spectroscopy: A Smart and Scalable Approach to High-Performance Analysis

 Agilent Cary 3500 UV-Vis spectrophotometer series was developed from the ground-up to address UV-Vis pain points and go beyond traditional user experiences.

Smart and Scalable High-Performance UV-Vis Analysis

The bioprocessing industry has identified an urgent need to intensify downstream operations, making them smaller, faster, and more cost-effective. While numerous technologies and techniques exist to intensify individual unit operations, implementing an integrated next-generation bioprocess presents significant challenges. Our collaboration with Transcenta has culminated in the development of a state-of-the-art, highly automated bioprocessing train for the manufacture of monoclonal antibodies and other biologics.
This webinar will detail the bioprocessing template, operational paradigm, and the complexities involved in qualifying such an advanced manufacturing method.
In this webinar, you will learn:
<ul>
<li>What constitutes an intensified bioprocess,</li>
<li>Transcenta&#39;s template for next-generation bioprocess capability,</li>
<li>The installation and qualification of a multi-column chromatography system and a flow-through polishing system,</li>
<li>Strategies for managing and qualifying long-duration bioprocessing challenges, such as bioburden control.</li>
</ul>
An on-demand version of this webinar will be available after the live event using the same link. Register now and access the webinar at your convenience.
<blockquote>
Presenter: Jerome Dalin (Associate Director – Alliance Management, BioContinuum™ Business Franchise)
</blockquote>
<blockquote>
Jerome Dalin holds an MSc/Engineering degree in Industrial Manufacturing and Biological Engineering. He began his career at Sanofi Pasteur 21 years ago, focusing on vaccine process development in France, Canada &amp; USA. In 2013, Jerome joined our company to manage bioprocessing sales and later transitioned to the Strategy organization to lead global initiatives for vaccines and the Factory of the Future. In his current role, Jerome is at the helm of Alliance Management, driving the development of the BioContinuum™ platform across the biopharmaceutical industry.
</blockquote>
<blockquote>
Presenter: Kara Pizzelli (Downstream Process Strategic Product Manager, Biocontinuum™ Business Franchise)
</blockquote>
<blockquote>
Kara Pizzelli holds a MSc degree in Chemical Engineering. Her career started at our company 25 years ago focusing on the optimization and scale-up of the unit operations from Clarification to Bulk Drug Filtration for customers in the US. Kara more recently managed the global Clarification business, owning the strategy and innovation, before taking on the role of DSP Strategic Product Manager in the Biocontinuum™ Business Franchise in 2023.
</blockquote>
<blockquote>
Presenter: Chris Hwang (EVP, CTO, Transcenta)
</blockquote>
<blockquote>
Chris Hwang holds a Ph.D. in Biochemical Engineering from MIT and has over 30 years of experience in the biopharmaceutical industry. He began his career at Genzyme and later at Sanofi, supporting and leading CMC development as well as process and technology development. He also served as project lead for the Integrated Continuous Biomanufacturing platform program. Chris joined HJB/Transcenta in 2016, where he is responsible for CMC development and developing and industrializing highly intensified biomanufacturing platforms to increase facility output, enhance process control, and reduce the cost of goods to expand patient access to innovative biologics.
</blockquote>
<blockquote>
Presenter: Jewell Zhou (Lead Scientist – CMC Process Development, Downstream Platform, Transcenta)
</blockquote>
<blockquote>
Jewell Zhou holds a Msc/Engineer degree in Biology and Bioprocessing Engineering. He joined the HJB company in 2018 as a scientist to develop downstream purification process for CMC. Since 2020, he joined the HJB HiCB group and started to build and support continuous purification platform for advanced antibody manufacturing. In his current role, Jewell is working on HICB/Transcenta platform development and supporting continuous manufacturing control strategy.
</blockquote>
<blockquote>
Presenter: Dr. Paul Beckett (Senior Strategic Product Manager – Clarification and Chromatography GTM Lead)
</blockquote>
<blockquote>
Paul holds a bachelor’s degree in biochemistry from Imperial College London and has a master’s degree and doctorate in biochemical engineering from University College London. Paul has worked in the pharmaceutical industry for 20 years and has held a number of roles in this capacity, including managing bioprocesses for early phase clinical material, CMC regulatory affairs consultancy and programme management of the next generation bioprocessing initiative. His current role is the global GTM lead for the chromatography and clarification technologies at our company.
</blockquote>

Merck: Collaborative Bioprocessing: Next-Gen mAb Downstream Manufacturing Enhanced by Transcenta Partnership

Collaborative Bioprocessing: Next-Gen mAb Downstream Manufacturing Enhanced by Transcenta Partnership

This webinar will detail the bioprocessing template, operational paradigm, and the complexities involved in qualifying such an advanced manufacturing method.

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