<p><strong>This workflow confirms and quantifies 31 drugs of abuse in oral fluid (including THC) in a 4.5‑minute LC run on the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1149"><strong>Thermo Scientific Stellar mass spectrometer</strong></a><strong> using full scan + targeted MS2 (tMS2) with both HCD and CID fragmentation. With 1 µL injection and 0.1% formic acid in water/methanol mobile phases, the method supports ~13 samples/hour (up to ~320/day continuous operation) while maintaining confirmation performance via ion ratios.</strong></p><blockquote><h5><strong>Method at a glance</strong></h5><ul><li><strong>What matrix is tested?</strong> Oral fluid</li><li><strong>How many drugs?</strong> 31 drugs of abuse (panel includes THC)</li><li><strong>Run time?</strong> 4.5 minutes</li><li><strong>Throughput?</strong> ~13 samples/hour → up to ~320 samples/day (24‑hour operation)</li><li><strong>Injection volume?</strong> 1 µL</li><li><strong>Mobile phases?</strong> 0.1% formic acid in water (A) and 0.1% formic acid in methanol (B)</li><li><strong>MS acquisition?</strong> Full scan + targeted MS2 (tMS2)</li><li><strong>Fragmentation?</strong> Compound‑optimized <strong>HCD</strong> and <strong>CID</strong> in the same targeted list</li><li><strong>Confirmation strategy?</strong> Ion ratios with ±20% tolerance (typical confirmatory approach)</li></ul></blockquote><h3><strong>Why oral fluid—and why speed matters</strong></h3><p>Oral fluid is attractive for clinical and forensic toxicology because collection is simple and the matrix aligns well with high‑volume workflows (workplace/occupational, roadside, and other settings). The challenge is building a method that’s simultaneously:</p><ul><li><strong>Broad enough</strong> for today’s drug panels</li><li><strong>Sensitive enough</strong> to reach required cutoffs</li><li><strong>Fast enough</strong> to keep sample queues under control</li><li><strong>Confirmation‑ready</strong> (consistent product ions and ion ratios)</li></ul><p>A <strong>4.5‑minute</strong> method is a practical lever here: compress runtime, raise throughput, and still keep confirmation quality by optimizing MS/MS conditions per compound.</p><h3><strong>The LC method</strong></h3><p>A short, efficient separation is the foundation of the workflow:</p><ul><li><strong>UHPLC system:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744"><strong>Thermo Scientific Vanquish Horizon UHPLC</strong></a></li><li><strong>Column:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/424"><strong>Thermo Scientific Accucore Biphenyl</strong></a>, 50 × 2.1 mm, 2.6 µm</li><li><strong>Mobile phase A:</strong> 0.1% formic acid in water</li><li><strong>Mobile phase B:</strong> 0.1% formic acid in methanol</li><li><strong>Injection volume:</strong> <strong>1 µL</strong></li><li><strong>Gradient runtime:</strong> <strong>4.5 minutes</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_4_5_Minute_Oral_Fluid_LC_MS_Method_to_Detect_31_Drugs_of_Abuse_Using_Stellar_MS_fd3f3e8ea4.jpg" alt="Thermo Fisher Scientific: 4.5-Minute Oral Fluid LC MS Method to Detect 31 Drugs of Abuse Using Stellar MS: Figure 1: Thermo Scientific Vanquish Horizon UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_4_5_Minute_Oral_Fluid_LC_MS_Method_to_Detect_31_Drugs_of_Abuse_Using_Stellar_MS_fd3f3e8ea4.jpg 120w," sizes="100vw" width="747" height="969"></p><h3><strong>The MS method (Full scan + targeted MS<sup>2</sup> with HCD + CID)</strong></h3><h5><strong>Acquisition approach</strong></h5><p>This method uses a “two‑layer” strategy for quantitation + confirmation:</p><ol><li><strong>Full scan</strong> (broad coverage, context, quantitative support)</li><li><strong>Targeted MS<sup>2</sup> (tMS2)</strong> (confirmation‑focused product ions, ion ratios)</li></ol><h5><strong>The key differentiator: HCD and CID in one targeted list</strong></h5><p>Instead of forcing every analyte into a single fragmentation style, the method uses both:</p><ul><li><strong>HCD</strong> (beam‑type fragmentation)</li><li><strong>CID</strong> (resonance‑type fragmentation)</li></ul><h5><strong>Why that improves method development:</strong></h5><p>Drugs of abuse span multiple chemistries. A single collision approach often works “okay” for most compounds—but one or two analytes can become persistent problems (weak qualifiers, unstable ion ratios, excess noise). Having both <strong>HCD and CID</strong> available in one method lets you optimize per compound and move faster.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_4_5_Minute_Oral_Fluid_LC_MS_Method_to_Detect_31_Drugs_of_Abuse_Using_Stellar_MS_3_e4a95651a2.jpg" alt="Thermo Fisher Scientific: 4.5-Minute Oral Fluid LC MS Method to Detect 31 Drugs of Abuse Using Stellar MS: Figure 2: Thermo Scientific Stellar mass spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_4_5_Minute_Oral_Fluid_LC_MS_Method_to_Detect_31_Drugs_of_Abuse_Using_Stellar_MS_3_e4a95651a2.jpg 245w," sizes="100vw" width="645" height="377"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_4_5_Minute_Oral_Fluid_LC_MS_Method_to_Detect_31_Drugs_of_Abuse_Using_Stellar_MS_5_88276eec6a.jpg" alt="Thermo Fisher Scientific: 4.5-Minute Oral Fluid LC MS Method to Detect 31 Drugs of Abuse Using Stellar MS: Figure 3: Full scan &amp; targeted MS2 methods, HCD and collision energies used." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_4_5_Minute_Oral_Fluid_LC_MS_Method_to_Detect_31_Drugs_of_Abuse_Using_Stellar_MS_5_88276eec6a.jpg 245w," sizes="100vw" width="768" height="279"></p><h3><strong>Why CID + HCD flexibility improves confirmation</strong></h3><p>In this workflow, <strong>HCD</strong> performed well for most compounds. But for <strong>buprenorphine</strong>, HCD produced one dominant product ion with additional low m/z noise and noticeable residual precursor. Using <strong>CID</strong> generated two high‑intensity product ions and delivered <strong>consistent ion ratios</strong> across the calibration range.</p><p>When your confirmation hinges on stable ion ratios, the ability to switch fragmentation mode (not just collision energy) is a method‑development advantage—especially for “problem analytes.”</p><h3><strong>Controllable ionization</strong></h3><p>Oral fluid methods often deal with limited sample volume and matrix effects. This workflow pairs low injection volume with ionization control using the Thermo Scientific OptaMax Plus HESI source.</p><ul><li>The OptaMax Plus HESI source supports high probe temperature capability (up to 650 °C).</li><li>In this study, a vaporizer temperature of 500 °C was used to help achieve sensitivity and improve relative peak areas across drugs of abuse.</li></ul><p><strong>Why this matters:</strong> If you’re injecting only 1 µL, ionization stability and efficiency can be the difference between “meets cutoff” and “misses at LOQ.”</p><h3><strong>Sample preparation</strong></h3><p>Oral fluid panels become more challenging when THC is included because most drugs of abuse are basic, while THC is largely neutral, and that can stress extraction chemistry.</p><p>In this workflow, oral fluid calibrators and samples were extracted using a mixed‑mode approach designed to recover THC alongside other drugs:</p><ul><li>Calibrators prepared across eight levels (broad dynamic range)</li><li>Extraction performed using mixed‑mode chemistry tips (SCX/WAX) in a dispersive SPE‑style workflow</li><li>Steps automated on a liquid handling platform to support high‑throughput consistency</li><li>Samples dried and reconstituted prior to LC‑MS analysis</li><li>Only 1 µL injected per run</li></ul><p>Even if your lab uses different automation or consumables, the method structure (fast LC + full scan + targeted MS2 with dual fragmentation) transfers well.</p><blockquote><h5><strong>Throughput math</strong></h5><ul><li><strong>4.5 minutes per injection</strong> → 60 / 4.5 = <strong>13.3 injections/hour</strong></li><li>That’s <strong>~13 samples/hour</strong> in typical phrasing</li><li>Over 24 hours: 13.3 × 24 = <strong>~320 samples/day</strong> (continuous operation)</li></ul><p>If you run a single shift, just scale accordingly (e.g., ~106/day for an 8‑hour shift, excluding QC and overhead).</p></blockquote><h3>Performance summary</h3><h5><strong>Sensitivity and linearity</strong></h5><ul><li><strong>Linearity</strong> from LOQs as low as <strong>0.25 ng/mL</strong> up to <strong>1,000 ng/mL</strong> (panel-dependent)</li><li>For THC specifically: <strong>LOQ at 1 ng/mL</strong>, with a dynamic range extending to <strong>1,000 ng/mL</strong> in this evaluation</li><li>Across the panel, LOQs were reported as <strong>lower than recommended confirmation cutoffs</strong> referenced in SAMHSA guidance and NSC Tier 1 cutoffs (study-specific outcome)</li></ul><h5><strong>Confirmation via ion ratios</strong></h5><ul><li>Ion ratios evaluated using <strong>±20% tolerance</strong> (typical confirmatory acceptance framework)</li><li>The workflow produced <strong>consistent ion ratios across calibrator levels</strong> for the full panel in this evaluation</li></ul><h5><strong>Case sample comparison (real-world relevance)</strong></h5><p>When compared against a validated triple quadrupole method for case study samples, the Stellar MS workflow:</p><ul><li>Confirmed the positive hits observed by the reference method</li><li>Reported a few additional positives for select analytes, attributed to lower LOQs</li><li>Highlighted an operational efficiency point: <strong>1 µL injection</strong> in this method versus <strong>20 µL injection</strong> in the compared method</li></ul><h3><strong>FAQ</strong></h3><div><div><ol><li><strong>How long does the LC‑MS run take for the 31‑drug oral fluid panel?</strong><br><strong>4.5 minutes per injection</strong> using a short UHPLC gradient.<br>&nbsp;</li><li><strong>How many drugs of abuse can Stellar MS detect in this workflow?</strong><br><strong>31 drugs of abuse</strong>, including <strong>THC</strong>, using full scan + targeted MS2.<br>&nbsp;</li><li><strong>What MS/MS approach is used?</strong><br>A combined strategy: <strong>full scan</strong> plus <strong>targeted MS2 (tMS2)</strong> for confirmation.<br>&nbsp;</li><li><strong>Why use both HCD and CID?</strong><br>Because some analytes fragment better—and produce more stable confirmation ions/ion ratios—under one mode versus the other. Using both increases flexibility and speeds method optimization.<br>&nbsp;</li><li><strong>What injection volume is used?</strong><br><strong>1 µL</strong> of extracted sample.<br>&nbsp;</li><li><strong>What mobile phases are used?</strong><br><strong>0.1% formic acid in water (A)</strong> and <strong>0.1% formic acid in methanol (B)</strong>.<br>&nbsp;</li><li><strong>How many samples can you run per day?</strong><br>At 4.5 minutes/injection, throughput is <strong>~13 samples/hour</strong> or <strong>up to ~320/day</strong> with continuous operation (actual throughput depends on QC and scheduling).</li></ol></div></div><h3><strong>What makes this workflow “easy” to develop on Stellar MS</strong></h3><p>Here’s the short list of features that directly reduce method‑development friction:</p><ul><li><strong>HCD or CID</strong> in one method → optimize per compound, not compromise</li><li><strong>Fast MS2 acquisition speeds</strong> (up to 140 Hz for MS2) → more data points across narrow peaks</li><li><strong>Fast polarity switching</strong> (true 5 ms) → supports mixed panels efficiently</li><li><strong>Adaptive RT</strong> (real‑time retention time window adjustment) → helps reduce reinjections when retention times drift (e.g., column aging) and supports method transfer from longer to shorter gradients</li><li><strong>OptaMax Plus HESI</strong> source control → supports sensitivity at low injection volumes</li></ul><p><i>If you’re building a fast oral fluid confirmation workflow—or updating an existing DOA panel—this 4.5‑minute method shows how Stellar MS can combine <strong>speed, confirmation-ready MS2, and fragmentation flexibility (HCD + CID)</strong> in a single targeted workflow. Reach out to learn how to adapt the targeted list, collision settings, and scheduling strategy to your lab’s cutoffs and throughput goals.</i></p><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#MassSpectrometry #OralFluid #DrugsOfAbuse #MethodDevelopment #HighThroughput</p></blockquote>

4.5-Minute Oral Fluid LC MS Method to Detect 31 Drugs of Abuse Using Stellar MS

<h2><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/"><strong>ISC 2026</strong></a></h2><p><strong>The </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/314"><strong>International Symposium on Chromatography (ISC)</strong></a><strong> represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/644"><strong>35th International Symposium on Chromatography</strong></a></h4><p>📆<strong>6. - 10. September 2026</strong></p><p>📍<strong>Prague, Czech Republic</strong></p><h3><strong>REGISTRATION</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal"><strong>Register HERE for the ISC 2026</strong></a></p><p><strong>Late Registration until 25 August 2026</strong></p></blockquote><h3><strong>INDUSTRY ACTIVITIES</strong></h3><h4><strong>Activity 1: Discussion Session: Industry &amp; Education</strong></h4><ul><li>Monday, 7 September 2026 | 16:30-17:50</li><li><strong>Place:</strong> Club A</li><li><strong>Moderators:</strong> Tony Edge and Deirdre Cabooter&nbsp;</li></ul><h5><strong>Concept:</strong></h5><p>This discussion session will explore the relationship between education in separation science in academia and the expectations of industry, focusing on how universities and companies can better collaborate to prepare graduates for successful careers in analytical laboratories and R&amp;D environments.<br>The goal of the session is to provide perspectives from both academia and industry on how education in chromatography and related separation techniques can evolve to better reflect current technological, methodological, and regulatory challenges.</p><h5><strong>Discussion Topics:</strong></h5><ul><li><strong>Bridging academia and industry: </strong>how both sectors perceive current cooperation and where improvements are possible&nbsp;</li><li><strong>Graduate preparedness:</strong> which skills and competencies are often missing when entering industrial roles, and in which areas graduates typically excel&nbsp;</li><li><strong>Approaches to teaching separation science:</strong> how chromatography and related analytical techniques are taught across different universities and regions&nbsp;</li><li><strong>Industry support for education: </strong>examples of collaboration such as internships, industrial placements, joint teaching activities, or access to instrumentation&nbsp;</li><li><strong>Experiences with academia–industry partnerships: </strong>what models of cooperation have proven effective in practice&nbsp;</li><li><strong>Future perspectives</strong>: how education in separation science should adapt to emerging trends such as automation, digitalization, sustainability, and regulatory requirements&nbsp;</li></ul><h5><strong>Format:</strong></h5><p>Moderated panel discussion with short introductory remarks from invited speakers representing both academia and industry, followed by an interactive discussion with the audience.</p><h5><strong>Panelists:</strong></h5><ul><li>Shimadzu&nbsp;</li><li>Novartis&nbsp;</li><li>Jelle De Vos, RIC Group&nbsp;</li><li>Davy Guillarme, University of Geneva&nbsp;</li><li>Caterina Temporini, University of Pavia&nbsp;</li></ul><h4><strong>Activity 2: Career Presentation&nbsp;</strong></h4><ul><li>Monday, 7 September 2026 | 18:00-19:00</li><li><strong>Place: </strong>Club A</li><li><strong>Moderators: </strong>Adrian Clarke and Martina Catani</li></ul><h5><strong>Concept:</strong></h5><p>This session will provide an overview of career opportunities in separation science across industry, highlighting the wide range of professional pathways available to graduates and experienced scientists working in chromatography and related analytical disciplines.</p><p>Participating companies will introduce their organizations, present typical roles involving separation techniques, and share insights into the skills and competencies they seek in candidates. The session is intended to support students, early-career researchers, and experienced professionals interested in exploring career options in industry sectors.</p><h5><strong>Discussion Topics:&nbsp;</strong></h5><ul><li>Overview of career paths involving chromatography and separation science&nbsp;</li><li>Entry-level opportunities for graduates and PhD holders&nbsp;</li><li>Positions for experienced scientists and technical specialists&nbsp;</li><li>Roles in R&amp;D, analytical development, quality control, regulatory science, application support, and instrument development&nbsp;</li><li>Skills and competencies valued by employers in separation science&nbsp;</li><li>Internships, graduate programs, and early-career development opportunities&nbsp;</li><li>Mobility between academia and industry&nbsp;</li></ul><h5><strong>Format:</strong></h5><p>Short presentation providing:</p><ul><li>overview of different carrier paths&nbsp;</li><li>introduction to the company and its activities related to separation science&nbsp;</li><li>examples of typical roles and career progression paths&nbsp;</li><li>information about current or expected hiring needs&nbsp;</li><li>advice for candidates interested in pursuing careers in industry&nbsp;</li><li>the session should include time for informal discussion, allowing participants to interact with company representatives and learn more about specific opportunities.&nbsp;</li></ul><h4><strong>Activity 3: Job Fair</strong></h4><ul><li>Monday, 7 September and Tuesday, 8 September 2026 | 12:30-14:00</li><li><strong>Place: </strong>Club A</li><li><strong>Main organizer:</strong> Adrian Clarke</li></ul><h5><strong>Concept:</strong></h5><p>The ISC 2026 Job Fair provides a structured opportunity for direct interaction between companies active in separation science and conference participants seeking career opportunities. The session is designed to facilitate efficient, focused conversations between employers and candidates interested in positions related to chromatography and analytical science.</p><p>Participating candidates will submit their CV in advance allowing companies to review profiles prior to the event and identify potential matches based on expertise, experience, and career interests.</p><h5><strong>Format:</strong></h5><p>The Job Fair will follow a structured rotation format:</p><ul><li>Each participating company will be assigned a dedicated table&nbsp;</li><li>One company representative will meet candidates individually&nbsp;</li><li>Each candidate will have 5 minutes per meeting to introduce their background and interests&nbsp;</li><li>Participants will rotate between companies at timed intervals&nbsp;</li><li>Session timing will be managed by the organizer, with a signal indicating when to move to the next meeting&nbsp;</li></ul><h5><strong>Candidates:</strong></h5><p>Participants interested in joining the Job Fair are asked to:</p><ul><li>submit their CV before August 23rd &nbsp;</li><li>indicate areas of expertise and career interests&nbsp;</li><li>specify whether they are seeking internships, entry-level roles, or experienced positions&nbsp;</li><li>specify if you cannot be available on a certain day e.g. owing to poster presentation&nbsp;</li><li>send these materials to: <a href="mailto:careers@isc2026.org">careers@isc2026.org</a>&nbsp;</li></ul><h5><strong>Companies:</strong></h5><p>Confirmed participating companies to date include:</p><ul><li>Novartis&nbsp;</li><li>RIC Group&nbsp;</li><li>Shimadzu&nbsp;</li><li>further companies to be added&nbsp;</li></ul><p>Potential employers please register your interest to <a href="mailto:careers@isc2026.org">careers@isc2026.org</a> to participate in the speed-dating (first come first served basis).</p><p>“<strong>Jobs position</strong>” board will be available in the Careers fair in the foyer in the symposium venue and attendees can visit the company booths in the exhibition hall or discuss with recruiting companies during the conference.</p><blockquote><p>Recruiters please send an email with your open positions to <a href="careers@isc2026.org">careers@isc2026.org</a> by the <strong>23rd August</strong> and bring the job adverts to post on the jobs board (there will also be the possibility to upload the open positions to the Symposium app).</p></blockquote><h4><strong>Activity 4: Discussion Session: Artificial Intelligence in Separation Science: From Concept to Practice</strong></h4><ul><li>Tuesday, 8 September 2026 | 16:30-18:00</li><li>Place: Club A</li><li><strong>Moderators:</strong> Bob Pirok</li></ul><h5><strong>Concept:</strong></h5><p>Artificial intelligence (AI) and data-driven approaches are increasingly influencing analytical chemistry, offering new possibilities for method development, data interpretation, process optimization, and decision support. This discussion session will explore how AI is currently being applied in separation science, with a particular focus on practical implementation in industry environments.</p><p>The session aims to provide a realistic overview of the current state of AI adoption, highlighting both successful applications and remaining challenges. Contributions from industry and academia will help clarify where AI already delivers value, where expectations may exceed current capabilities, and what developments are needed to enable broader implementation.</p><h5><strong>Discussion Topics:&nbsp;</strong></h5><ul><li>Current applications of AI and machine learning in separation science&nbsp;</li><li>Use of AI in chromatographic method development and optimization&nbsp;</li><li>Data analysis, peak detection, and automated interpretation of complex datasets&nbsp;</li><li>AI-supported troubleshooting and predictive maintenance of analytical instruments&nbsp;</li><li>Integration of AI into regulated environments (e.g., pharmaceutical industry)&nbsp;</li><li>Data requirements, data quality, and standardization challenges&nbsp;</li><li>Comparison between academic developments and real-world industrial implementation&nbsp;</li><li>Barriers to adoption, including regulatory considerations, validation requirements, and transparency of models&nbsp;</li><li>Future outlook: digital laboratories, autonomous method development, and AI-assisted decision-making in analytical workflows&nbsp;</li></ul><h5><strong>Format:</strong></h5><p>Moderated panel discussion with short introductory remarks from invited speakers representing both academia and industry, followed by an interactive discussion with the audience.</p><h4><strong>Activity 5: Discussion Session: Sustainability in Separation Science</strong></h4><ul><li>Wednesday, 9 September 2026 | 16:30-18:00</li><li><strong>Place:</strong> Club A</li><li><strong>Moderators:</strong> Gertrud Morlock</li></ul><h5><strong>Concept:</strong></h5><p>Sustainability has become an increasingly important priority in analytical science, driving the development of greener methods, reduced solvent consumption, improved energy efficiency, and more responsible laboratory practices. While academic research frequently proposes innovative sustainable approaches, their implementation in industry is often influenced by additional considerations such as robustness, regulatory compliance, cost efficiency, scalability, and long-term reliability.</p><p>This discussion session aims to explore how sustainability principles are applied in real industrial environments and how collaboration between academia and industry can help translate promising research concepts into practical, validated solutions.</p><p>By bringing together perspectives from both sectors, the session will highlight opportunities to better align research priorities with industrial needs and identify realistic pathways toward more sustainable separation workflows.</p><h5><strong>Discussion Topics:&nbsp;</strong></h5><ul><li>Reduction of solvent consumption and the transition to more environmentally friendly mobile phases&nbsp;</li><li>Miniaturized and more efficient separation and extraction techniques&nbsp;</li><li>Energy consumption and efficiency of laboratory processes and analytical instrumentation&nbsp;</li><li>Lifecycle considerations for columns, consumables, and laboratory waste&nbsp;</li><li>Metrics and approaches for measuring and evaluating the “greenness” of analytical methods&nbsp;</li><li>Regulatory constraints and requirements that may limit the implementation of greener analytical workflows&nbsp;</li></ul><h5><strong>Format:</strong></h5><p>Moderated panel discussion with short introductory contributions from invited speakers representing industry, academia, and technology providers, followed by interactive discussion with the audience.</p><h5><strong>Panelists:</strong></h5><ul><li>Sébastien Rolle, Shimadzu&nbsp;</li><li>Ken Cook, Thermo Fisher Scientific&nbsp;</li><li>Andreas Otto, Agilent&nbsp;</li><li>Janusz Pawliszyn, University of Waterloo&nbsp;</li><li>Giorgia Purcaro, University of Liège&nbsp;</li></ul>

Industry program at ISC 2026

<p><strong>We are delighted to invite food scientists from academia and industry, representatives of (inter)national agencies, control authorities, governmental and commercial laboratories to attend </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/928"><strong>RAFA 2026</strong></a><strong> (12th Symposium on Recent Advances in Food Analysis), that takes place 3–6 November 2026 in Prague..</strong></p><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://rafa.easyevent.eu/tickets/"><strong>SUBMIT ABSTRACT</strong></a> <strong>FOR POSTER PRESENTATION by August 31, 2026</strong></p><p>Do not miss the opportunity to present your latest results at <strong>RAFA 2026</strong>.</p></blockquote><h5><strong>Next deadlines:</strong></h5><ul><li><strong>August 31, 2026</strong>: 2nd window – &nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/sponsors_exhibitors_media_partners_info.html"><strong>Application for participation as a Sponsor or Exhibitor</strong></a></li><li><strong>September 30, 2026:&nbsp;</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/registration.html"><strong>Registration at the regular rate</strong></a></li><li><strong>Abstract submission</strong> – <strong>Last minute posters </strong>(<i>May not appear in the RAFA 2026 program</i>)</li></ul></li></ul><p>Since its first edition in 2003, RAFA has grown into a <strong>prestigious international event</strong>, typically welcoming <strong>up to 850 participants</strong> from more than <strong>60 countries</strong> worldwide, with the support of more than 50 sponsors, exhibitors, media and supporting partners.</p><p>RAFA 2026 will provide an overview of contemporary trends in the <strong>ANALYTICAL &amp; BIOANALYTICAL STRATEGIES IN FOOD QUALITY AND SAFETY CONTROL</strong> and discuss the <strong>CHALLENGES AND NOVEL APPROACHES IN FOOD AND NATURAL PRODUCTS ANALYSIS</strong>.</p><p>View the <a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/invited_speakers.html"><strong>list of distinguished speakers</strong></a> who have accepted our invitation to RAFA 2026 and will present current hot topics and future perspectives in food analysis!</p><blockquote><p>👉More details on the <a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/scientific_programme.html"><strong>RAFA 2026 preliminary program</strong></a> can be found HERE.</p><p>👉OUR <a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/about_sponsors_exhibitors_partners.html"><strong>SPONSORS, EXHIBITORS, MEDIA and SUPPORTING PARTNERS</strong></a></p></blockquote><p>You are kindly invited to join and contribute to our exciting scientific program and unforgettable social events!</p><p><strong>We look forward to meeting you again in Prague!</strong></p><ul><li>Prof. Jana Pulkrabova &amp; Dr. Stefan van Leeuwen, Symposium Chairs</li><li>Prof. Michele Suman, Symposium Co-chair</li><li>Prof. Jana Hajslova &amp; Prof. Michel Nielen, Symposium Honorary Chairs</li></ul>

RAFA 2026 - Deadline for Abstract Submission for poster presentation is coming

Article

Product

Events

Application

Food

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RAFA provides an overview of contemporary trends in ANALYTICAL & BIOANALYTICAL STRATEGIES IN FOOD QUALITY AND SAFETY CONTROL and discusses CHALLENGES / NOVEL APPROACHES IN FOOD AND NATURAL PRODUCTS ANALYSIS.

Recent Advances in Food Analysis (RAFA)

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Separation Science

Agilent Technologies

Technology Networks

SCIEX

Waters Corporation

<h4><strong>Virtual event: Pharma conclave series 2024</strong></h4><p>SCIEX offers the platform for the experts to take the stage and drive technological progress</p><p><strong>Welcome to Pharma conclave series 2024</strong> – where our customers’ expertise meets innovation, transforming your knowledge and empowering you to revolutionize your work processes. Join us in discovering techniques that will enhance your skills to accelerate your daily operations in the development of new drugs.</p><p>From the research of new markers to the drug development moving into non and GLP bioanalysis. Confidently plan your next lab expansion with the knowledge gained from industry leaders and pioneers.</p><ul><li>May 16 <strong>Event 1: Pharma omics</strong></li><li>September 17 <strong>Event 2: Impurities</strong></li><li>October 23-24 <strong>Event 3: Pharma</strong></li></ul><p><strong>10:00 a.m.–12:00 p.m. CET</strong></p><h3><strong>Event 3: Pharma</strong></h3><p><strong>The pharma connection</strong></p><p>From discovery to QA/QC. All the process to bring a new treatment to the patients is following a path to connect the different stages until the magic happens.</p><p>Join to see how the scientists are generating the needed tricks to connect the initial though with the final formulation.</p><h3><strong>Day 1</strong></h3><h5><strong>10:00 - 10:30 - Metabolomics screening kits for use in clinical trials</strong></h5><ul><li>Heike Wiese, Nuvisan</li></ul><h5><strong>10:30 – 11:00&nbsp;- Sphingolipid biomarkers in neurodegenerative drug development</strong></h5><ul><li>Jose Carlos Gonzalez, AMSbiopharma</li></ul><h5><strong>11:00 – 11:30 - Parallel setup of a series of micro LC methods, coupled with the low-resolution mass spec (API7500) for &nbsp;TG2 inhibitors</strong></h5><ul><li>Davide Massari and Chiara Olmi, ERBC Group</li></ul><h5><strong>11:30 – 12:00&nbsp;- PFAS analysis and mass spectrometry: Beyond environmental, food and packaging. What about cosmetic and pharmaceutical products?</strong></h5><ul><li>Emiliano De Dominicis, Merieux</li></ul><blockquote><p><strong>Presenter:</strong> Bruno Manadas, PhD</p></blockquote><blockquote><p>Dr Manadas is a prominent Cell Biology researcher at CNC-UC since 2017. With expertise in biochemistry, psychology, and biotechnology, he's authored 130+ publications and led multiple projects. As head of CNC's Mass Spectrometry node and Associate Editor for Frontiers, he's contributed significantly to neuroscience and psychiatry. Bruno's research focuses on cell biology mechanisms, translational biomarker research, and MS-based approaches for studying protein oxidation. He played a pivotal role in establishing the hospital biobank and teaches at the Portuguese Catholic University.</p></blockquote><blockquote><p><strong>Presenter:</strong> Dorte Bekker-Jensen</p></blockquote><blockquote><p>Dorte is heading the Applications Development team in Proteomics Research at Evosep. She has long-term experience within proteomics and has focused on technology development by developing simple and automated workflows for high-throughput applications.</p></blockquote><blockquote><p><strong>Presenter:</strong> Stefan Ledinger</p></blockquote><blockquote><p>Stefan has 20 years of experience in the life sciences and diagnostic industries. For the last dozen years, he has been serving various functions within biocrates life sciences ag. Most recently, he has been responsible for the market development for metabolomics solutions in the pharmaceutical and biotech industries. He currently serves as Global Head of Sales. Stefan holds degrees in business administration and bioengineering, combining commercial know-how with a passion for science.</p></blockquote><blockquote><p><strong>Presenter:</strong> Markus Langsdorf</p></blockquote><blockquote><p>Markus has 14 years of experience in life sciences industries. As he joined biocrates in 2010, he worked for 11 years as application support specialist for biocrates’ metabolomics profiling solutions. 3 years ago he changed his position withing the company to his new function as product manager. Markus studied chemistry and graduated with a PhD in Analytical Chemistry.</p></blockquote>

Pharma conclave series 2024: Pharma (Day1)

From discovery to QA/QC. The process to bring a new treatment to the patients.

<h4><strong>Virtual event: Pharma conclave series 2024</strong></h4><p>SCIEX offers the platform for the experts to take the stage and drive technological progress</p><p><strong>Welcome to Pharma conclave series 2024</strong> – where our customers’ expertise meets innovation, transforming your knowledge and empowering you to revolutionize your work processes. Join us in discovering techniques that will enhance your skills to accelerate your daily operations in the development of new drugs.</p><p>From the research of new markers to the drug development moving into non and GLP bioanalysis. Confidently plan your next lab expansion with the knowledge gained from industry leaders and pioneers.</p><ul><li>May 16 <strong>Event 1: Pharma omics</strong></li><li>September 17 <strong>Event 2: Impurities</strong></li><li>October 23-24 <strong>Event 3: Pharma</strong></li></ul><p><strong>10:00 a.m.–12:00 p.m. CET</strong></p><h3><strong>Event 3: Pharma</strong></h3><p><strong>The pharma connection</strong></p><p>From discovery to QA/QC. All the process to bring a new treatment to the patients is following a path to connect the different stages until the magic happens.</p><p>Join to see how the scientists are generating the needed tricks to connect the initial though with the final formulation.</p><h3><strong>Day 2</strong></h3><h5><strong>10:00 - 10:30&nbsp;- Metabolomics: From target engagement to metabolic phenotyping. Applications in drug discovery</strong></h5><ul><li>Filippos Michopoulos, Astrazeneca</li></ul><h5><strong>10:30 - 11:00&nbsp;- Development of an LC-MS Method to Quantify Endogenous Urea in Mouse Plasma and BAL.</strong></h5><ul><li>Benjamin Smith, Cyprotex</li></ul><h5><strong>11:00 - 11:30&nbsp;- Optimization of extraction &amp; LC-MS conditions for the bioanalysis of antibody drug conjugates with diverse chemistries</strong></h5><ul><li>John Perkins, KCAS</li></ul><h5><strong>11:30 - 12:00&nbsp;- Preparation of rodent whole blood and plasma microsamples for LC-MS/MS bioanalysis in toxicology studies</strong></h5><ul><li>Birgitte Støvring, Scantox</li></ul><blockquote><p><strong>Presenter:</strong> Bruno Manadas, PhD</p></blockquote><blockquote><p>Dr Manadas is a prominent Cell Biology researcher at CNC-UC since 2017. With expertise in biochemistry, psychology, and biotechnology, he's authored 130+ publications and led multiple projects. As head of CNC's Mass Spectrometry node and Associate Editor for Frontiers, he's contributed significantly to neuroscience and psychiatry. Bruno's research focuses on cell biology mechanisms, translational biomarker research, and MS-based approaches for studying protein oxidation. He played a pivotal role in establishing the hospital biobank and teaches at the Portuguese Catholic University.</p></blockquote><blockquote><p><strong>Presenter:</strong> Dorte Bekker-Jensen</p></blockquote><blockquote><p>Dorte is heading the Applications Development team in Proteomics Research at Evosep. She has long-term experience within proteomics and has focused on technology development by developing simple and automated workflows for high-throughput applications.</p></blockquote><blockquote><p><strong>Presenter:</strong> Stefan Ledinger</p></blockquote><blockquote><p>Stefan has 20 years of experience in the life sciences and diagnostic industries. For the last dozen years, he has been serving various functions within biocrates life sciences ag. Most recently, he has been responsible for the market development for metabolomics solutions in the pharmaceutical and biotech industries. He currently serves as Global Head of Sales. Stefan holds degrees in business administration and bioengineering, combining commercial know-how with a passion for science.</p></blockquote><blockquote><p><strong>Presenter:</strong> Markus Langsdorf</p></blockquote><blockquote><p>Markus has 14 years of experience in life sciences industries. As he joined biocrates in 2010, he worked for 11 years as application support specialist for biocrates’ metabolomics profiling solutions. 3 years ago he changed his position withing the company to his new function as product manager. Markus studied chemistry and graduated with a PhD in Analytical Chemistry.</p></blockquote>

Pharma conclave series 2024: Pharma (Day 2)

<p><strong>We invite you to join a hybrid event on October 15<sup>th</sup> to explore the latest solutions and workflows for overcoming environmental and food contaminant testing challenges.</strong></p><p>This event will be broadcast live from the laboratory at Thermo Fisher Scientific Customer Solutions Center (CSC) in Paris. You can join in person at one of our many 'satellite' venues worldwide, where we will offer an extended agenda, or participate remotely through the live broadcast.</p><p>During the live stream broadcast, you will meet our Customer Solution Centre specialist team and leading industry expert, John Quick, as they discuss innovative solutions to meet the ever-evolving testing demands. There will be plenty of time to ask these experts your questions.</p><p>The following sessions will be streamed all over Europe and beyond:</p><ul><li><strong>Detecting PFAS in drinking water to meet regulations across Europe</strong> – New automated sample preparation high-resolution MS solution to achieve parts per trillion detection limits.<br><i>Aristide Ganci,&nbsp;Senior Product Application Specialist, Thermo Fisher Scientific; Valérie Thibert, Senior Product Application Specialist, Thermo Fisher Scientific; Bénédicte Gauriat, Senior Product Application Specialist, Thermo Fisher Scientific</i></li><li><strong>New ready-to-go pesticide residue solution for faster, more confident results</strong><br><i>Zoe Julian, Product Marketing Specialist, Manager; Bénédicte Gauriat, Senior Product Application Specialist, Thermo Fisher Scientific; Julie Moriceau, Senior Product Application Specialist, Thermo Fisher Scientific</i></li><li><strong>Low-level contaminant testing in environmental water matrices</strong>&nbsp;– High-Resolution Accurate Mass GC-MS approach to meet future regulations<br><i>John Quick, Principal Scientist, ALS Environmental Ltd</i></li></ul><p>After the live stream concludes, 'satellite' locations offer a unique program onsite. Take this unique opportunity to connect with industry professionals, or join us to explore, network, and collaborate on your future projects. Scroll below to the venue of your choice to discover the individual agenda.</p><p>Participation is free of charge, registration is required.</p><p>For any questions about this event or regarding your registration, please email <a href="mailto:CMDEvents@thermofisher.com">CMDEvents@thermofisher.com</a>.</p><h3><strong>Preliminary agenda</strong></h3><h5><strong>10:15 Live streaming of this event to ‘satellite’ locations and online audience</strong></h5><h5><strong>10:30 Introduction</strong></h5><ul><li>Jeff Stubbs (Business Development Manager, Environment and Food Safety, Thermo Fisher Scientific)</li></ul><h5><strong>10:55 Detecting PFAS in drinking water to meet regulations across Europe - New automated sample preparation high-resolution MS solution to achieve ppt detection limits</strong></h5><ul><li>A Ganci, V Thibert and B Gauriat (Senior Product Application Specialists, Thermo Fisher Scientific)</li></ul><h5><strong>11:35 Break</strong></h5><h5><strong>12:05 New ready-to-go pesticide residue solution for faster, more confident results</strong></h5><ul><li>Z Julian, Product Marketing, B Gauriat, and J Moriceau (Senior Product Application Specialists Thermo Fisher Scientific)</li></ul><h5><strong>12:45 Low-level contaminant testing in environmental water matrices – high-resolution GCMS approach to meet future regulations</strong></h5><ul><li>John Quick (Principal Scientist, ALS Environmental Ltd)</li></ul><h5><strong>13:15 Closing comments</strong></h5><h5><strong>13:30 End of live streaming</strong></h5><div><div container-id="cq-colctrl-lt7" comp-id="B1"><div><div><div><div><div><div><blockquote><h3>How to attend?</h3><p>3 ways of attending:</p><p><strong>Customer Solution Centre (in-person event):&nbsp;</strong><br>Join the heart of the event at our Customer Solution Center in Paris, where the main agenda will be hosted and live-streamed worldwide to our ‘Satellite’ locations and our audience.</p><p><strong>Join a ‘Satellite’ location (in-person event):&nbsp;</strong><br>Our in-person ‘Satellite’ events will broadcast the main agenda live-streamed from our Customer Solution Center in Paris and supplement the day with local presentations, lab tours, or workshops. Take this opportunity to meet your Thermo Fisher representatives and industry experts from the region. Discover the individual agenda for your ‘Satellite’ location of interest.</p><p><strong>Online attendees (remote):&nbsp;</strong><br>Unable to travel to a ‘Satellite’ event? Not a problem! You can register to attend conveniently online from your desk or anywhere else through the live stream from our Customer Solutions Center in Paris.</p></blockquote></div></div></div></div></div></div></div></div>

Thermo Scientific: Solutions for environmental and food contaminant testing

Solutions for environmental and food contaminant testing

New and advancing workflows to meet and exceed European regulations.

<p><strong>Food allergies are a public health and regulatory challenge, with an estimated 1–2% of adults affected by food allergies. Risk analysis and management of allergens within the food and beverage industry rely on accurate allergen analysis.</strong></p><p>High-performance liquid chromatography high-resolution mass spectrometry (HPLC-HRMS) could be the future of food allergen analysis.</p><p>In this webinar, our expert speaker will discuss how HPLC-HRMS can detect a wide range of allergens in a single run, reducing the time and effort involved in food analysis. He’ll also highlight how integrating HPLC with HRMS approaches enhances accuracy and makes allergen detection more reliable, ensuring robust food safety and compliance with regulatory standards.</p><h4>Attend this webinar to:</h4><ul><li><strong>Learn how to multiplex allergen detection</strong><br>&nbsp;</li><li><strong>Improve the accuracy and speed of your food analysis</strong><br>&nbsp;</li><li><strong>Discover a complete workflow including sample preparation and data analysis</strong></li></ul><blockquote><p><strong>Presenter: </strong>Prof. Jens Brockmeyer (Head of Department, Food Chemistry, University of Stuttgart, Germany)</p></blockquote>

Technology Networks: Moving Towards the Next Generation of Food Allergen Analysis

Moving Towards the Next Generation of Food Allergen Analysis

How HPLC-HRMS can detect a wide range of allergens in a single run, reducing the time and effort involved in food analysis.

<p><strong>Clinical blood analysis is crucial for monitoring health and diagnosing diseases, with blood-based biomarkers playing a key role.</strong></p><p>However, current detection methods often lack sufficient coverage. Mass spectrometry-based proteomics provides a robust solution for in-depth plasma proteome analysis, but precise sample preparation is essential.</p><p>This webinar will guide you on maximizing plasma proteome coverage and optimizing sample preparation, whether using plasma or serum. Dr. König and Dr. Wendt will discuss developing an optimized, automated workflow for comprehensive plasma biomarker discovery, showcasing results from two complementary techniques: LC-MS and Olink.</p><h4>Attend this webinar to:</h4><ul><li><strong>Discover how to efficiently prepare blood-derived samples, including plasma and serum</strong></li><li><strong>Explore how to implement a fully automatable, reproducible and standardized plasma workflow with scalable throughput</strong></li><li><strong>Achieve comprehensive plasma proteome characterization, addressing the dynamic range challenge for deeper insights</strong></li><li><strong>Learn to apply LC-MS-based proteomics combined with affinity-based methods to discover novel disease biomarkers</strong></li></ul><blockquote><p><strong>Presenter: </strong>Dr. Ann-Christine König (Proteomics Core Facility Manager, Helmholtz Zentrum Munich)<br><br><strong>Presenter:&nbsp;</strong>Dr. Fabian Wendt (Product and Application Manager, Mass Spectrometry, Tecan)</p></blockquote>

Technology Networks: Unlocking the Plasma Proteome: Advanced Profiling and Biomarker Discovery

Unlocking the Plasma Proteome: Advanced Profiling and Biomarker Discovery

Maximizing plasma proteome coverage and optimizing sample preparation, whether using plasma or serum.

Unlocking the Plasma Proteome: Advanced Profiling

<p><strong>Join us as we introduce our path to visualize molecules from tissue at single cell resolution using DESI MS imaging, with the commercial DESI XS ionization source coupled to Xevo G3 QToF Mass Spectrometer.</strong></p><p>This webinar will explain how to easily transition to high resolution MS Imaging with a traditional entry level commercial DESI MS imaging toolkit.</p><h4>Learn how to:</h4><ul><li><strong>Understand High spatial resolution MS Imaging is now accessible to all labs and applications</strong></li><li><strong>Access single cell DESI Imaging with the combination of DESI XS and Xevo G3 QToF</strong></li><li><strong>Leverage both high sensitivity and high speed of acquisition with the Xevo G3 QToF without compromising MS Imaging data quality</strong></li><li><strong>Utilize HDI 1.8 Imaging software for microscope mode analysis for effective use of time in MS Imaging experiments</strong></li><li><strong>Obtain comprehensive and detailed spatial information with limited sample preparationAdd MSI analysis into a multi-modal imaging workflow with ease</strong></li></ul><blockquote><p><strong>Presenter:&nbsp;</strong>Dr Jamie Reilly (Postdoctoral Researcher, University of Galway)</p><p>Dr. Jamie Reilly is a postdoctoral researcher in NUIG Galway. Prior to joining the CELLIMAGE project, Jamie undertook his PhD in Regenerative Medicine in REMEDI, where he used bioinformatics to analyze molecular pathways in cellular and animal models of autism spectrum disorder (ASD). Jamie attended Trinity College Dublin (TCD) for his undergraduate degree in Genetics, and has a Masters in Biotechnology from Queens University Belfast.</p><p><strong>Presenter:&nbsp;</strong>Dr. Mark Towers (Principal Scientist - MS Technology, Waters)</p><p>Mark Towers gained his PhD from the University of Reading in Bioanalytical chemistry on the Development of applications and techniques for UV-Liquid-MALDI-MS. Mark joined Waters over 10 years ago into the Scientific operations team as a senior scientist, working on high resolution mass spectrometry and imaging.</p><p>Mark’s primary area of focus has been surface analysis by desorption electrospray ionisation (DESI) with over 7 years experience and matrix assisted laser desorption ionisation for over 14 years, principally but not limited to tissue sections for the detection and distribution mapping of a wide range of molecules.</p><p><strong>Presenter: </strong>Dr. Joanne Ballantyne (Director, MS Imaging program, Waters Corporation)</p><p>Joanne completed a PhD in Mass Spectrometry at UMIST in Manchester 2002, in collaboration with UK Ministry of Defence's Science and Technology Lab (Dstl). This was followed by a post-doc at NIH in Bethesda, USA, working in OMICS for the NIMH. After returning to the UK, and time as a MALDI applications chemist at Shimadzu Biotech, Joanne joined Waters Corporation in 2007 as a member of the OMICS Application team in Manchester and progressed to managing the team. Following this Joanne spent a number of years in Business Development and Field Marketing for discovery applications in the Northern European region. At the end of 2018 Joanne joined the Product Management group with responsibility for the SYNAPT and MS Imaging technologies. After gaining ILM7 accreditation in strategic leadership, Joanne is now Director of the MS Imaging program.</p></blockquote>

Waters Corporation: Towards Single Cell Imaging Session 1

Towards Single Cell Imaging Session 1

How to easily transition to high resolution MS Imaging with a traditional entry level commercial DESI MS imaging toolkit.

<p><strong>This session will provide a comprehensive introduction to the user interface, ensuring you can navigate with ease. Discover the various acquisition modes available and learn how to select the best one for your specific application.</strong></p><p>Additionally, we will explore the innovative Intelligent Reflex feature, highlighting its benefits in boosting your productivity.</p><p>Whether you’re new to MassHunter or looking to refine your skills, this webinar is designed to enhance your understanding and efficiency.</p><blockquote><p><strong>Presenter:</strong> Christian Hegmanns (Application Specialist LC/MS, Agilent Technologies, Waldbronn, Germany)</p><p>Christian Hegmanns is a state-certified food chemist and works at Agilent as an LC/MS application specialist.</p><p>With over 10 years of experience in the field of instrumental analysis, Christian develops customer-oriented solutions for a variety of applications with a focus on food analysis.</p></blockquote>

Agilent Technologies: MassHunter Masterclass Months

MassHunter Acquisition Q-TOF Part I – Basic Overview

Join us for an insightful webinar where we delve into the essentials of MassHunter Acquisition Q-TOF. 

<p><strong>This webinar will guide you through optimizing your Q-TOF for superior data quality by selecting the most suitable tune mode for your samples.</strong></p><p>We will delve into various MS acquisition modes, including MS only, All Ions (QRAI), Auto MS/MS (directed MS/MS; targeted MS/MS), and PRM mode.</p><p>Learn how to fine-tune method settings to enhance your data quality and achieve the best analytical results. Whether you’re a seasoned user or new to QTOF, this session will provide valuable insights to elevate your mass spectrometry.</p><blockquote><p><strong>Presenter:</strong> &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)</p><p>Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</p></blockquote>

MassHunter Acquisition Q-TOF Part II – Advance Settings

Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.

<div><div><p><strong>Therapeutic synthetic oligonucleotides represent unique analytical challenges in late-stage development. To meet the stringent regulatory requirements, highly specific and sensitive methods such as liquid chromatography-mass spectrometry (LC/MS) must be used. However, neither chromatography nor mass spectrometry data systems have the capabilities, both in function and in data integrity, for the typical QC analyst end user to run a highly complex method such as purity, assay, and impurity profiling for therapeutic oligos such as anti-sense oligonucleotides.</strong></p><p>In this presentation, we present a paradigm shift in software with Oligo Analysis Accelerator for OpenLab CDS. This application streamlines the analytical workflow by using a fit-for-purpose user interface while leveraging existing data integrity and compliance architecture within OpenLab CDS.</p><h4>By attending this webinar, you will:</h4><ul><li><strong>Understand the fundamentals of ion-pair reversed-phase LC/MS for oligonucleotides</strong></li><li><strong>Discover how a single quadrupole detector is used for impurity profiling of anti-sense oligonucleotides</strong></li><li><strong>Learn how fit-for-purpose software for LC/MS analysis in QC lot release can save time and enhance quality</strong></li></ul><h5>Who should attend</h5><ul><li>Analytical chemists interested in cutting-edge software for large molecule late-stage development</li><li>Analytical research and development labs interested in developing robust methods for single-stranded oligo therapeutics</li><li>Process scientists who rely on in-process control purity results to optimize synthesis and purification for oligos</li><li>Quality assurance and quality control personnel supporting oligo testing labs</li></ul><blockquote><p><strong>Presenter:</strong> Brian Rivera (Software Product Manager, Agilent Technologies)</p><p>Brian Rivera is a software product manager at Agilent Technologies with 20 years of experience in HPLC analysis of large molecules.</p></blockquote></div></div>

Separation Sciences: Boost Efficiency in Oligonucleotide QC with Software Designed for the Job

Boost Efficiency in Oligonucleotide QC with Software Designed for the Job

In this presentation, we present a paradigm shift in software with Oligo Analysis Accelerator for OpenLab CDS.

Oligonucleotide QC with Software Designed for the Job

<p id="isPasted"><strong>Biotherapeutics offer targeted therapies for treating a wide range of diseases with greater specificity and efficacy. However, unlike traditional small-molecule drugs, biotherapeutics are typically larger and more complex, requiring advanced techniques for their production, purification, and characterization.</strong></p><p>Therapeutic proteins, first introduced many years ago, have continually advanced in complexity. Since the introduction of monoclonal antibodies, we now have antibody drug conjugates, bispecific antibodies, fragments and fusion proteins, all of which are in various stages of development.&nbsp;</p><p>To keep pace with biotherapeutics advances, analytical techniques must also advance.&nbsp;</p><h5><strong>In this webinar, we will present chromatography findings on:</strong></h5><ul><li><strong>New workflows for intact and peptide mapping characterization of proteins</strong></li><li><strong>Advanced column chemistries for charge variant analysis with pH and salt gradients&nbsp;</strong></li><li><strong>Rapid desalting SEC column for high throughput analysis, ADC analysis with HIC and reversed phase chemistries</strong></li><li><strong>New digestion workflows coupled to a new peptide mapping column for sequence verification and post translation modification analysis</strong></li></ul><p>This live webinar will be an excellent opportunity to boost your R&amp;D capabilities and strengthen your QC analytical methods for the characterization of biotherapeutics and gene therapies. Dr. Ken Cook will be presenting and answering your questions live.</p><p>With over 20 years of innovation, Thermo Fisher Scientific is a leader in biomolecule separation and characterization, supported by a wealth of published research.</p><p id="isPasted"><strong fr-original-style="">Who should attend?&nbsp;</strong></p><ul><li><strong fr-original-style="">Pharmaceutical and Biotech Researchers</strong>: Researchers involved in the development and characterization of biotherapeutics and gene therapies, including those working with therapeutic proteins.</li><li><strong fr-original-style="">Quality Control (QC) Analysts</strong>: Analysts responsible for ensuring the quality and consistency of biotherapeutic products, who will benefit from advanced methods in characterization and validation.</li><li>&nbsp;<strong fr-original-style="">R&amp;D Managers</strong>: Managers who oversee research and development teams working with biotherapeutics, looking to enhance their workflows and methodologies.</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Ken Cook (Application Scientists Manager, Thermo Fisher Scientific)</p><p>Dr. Ken Cook began his career in academia as a Biochemistry lecturer focused on protein chemistry and metabolism. With over 30 years of industry experience at Dionex, and later Thermo Fisher Scientific, his vast knowledge supporting and developing solutions within chromatography has established him as a bio-separations expert.</p><p>Currently, Dr. Cook focuses on supporting and developing solutions for bio-pharmaceutical applications, particularly in the characterization of protein and oligonucleotide-based biotherapeutics. His work involves ongoing collaborations with both the biopharmaceutical industry and academic institutions.</p><p>His expertise includes peptide mapping using LC/HRMS, charged variant analysis with novel MS coupling, glycan analysis, aggregate analysis, and on-line process monitoring. He also has a growing interest and notable success in gene therapy characterization.</p><p>Given his immense experience, it is an honour to have Dr Cook share his knowledge.</p></blockquote>

Thermo Fisher Scientific: Innovations in Protein Characterization

Innovations in Protein Characterization

Boost your R&D capabilities and strengthen your QC analytical methods for the characterization of biotherapeutics and gene therapies.

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