<h3>A Dedicated Solution for Oligonucleotide Analysis</h3>Oligonucleotides have become key players in modern pharmaceutical and biological research, particularly in the development of highly targeted and personalized therapies. As increasing numbers of oligonucleotide-based drugs enter clinical trials or receive regulatory approval, analytical laboratories face growing demands for both throughput and data quality. These molecules present unique chromatographic challenges due to their long, highly polar structures and subtle variations in nucleobase sequence or functionalization.<h3>Sepapure oliGO – Designed for Oligonucleotide Separations</h3>Selecting the optimal chromatographic approach for oligonucleotide analysis can be complex. Many laboratories rely on ion-pair reversed-phase (IP-RP) chromatography because of its speed, robustness, and compatibility with mass spectrometry. However, commonly used ion-pair reagents can degrade conventional silica-based stationary phases.<a target="_blank" rel="noopener noreferrer" href="https://www.knauer.net/columns-oligonucleotide-columns">Sepapure oliGO</a> addresses this limitation through a hybrid silica matrix combined with specialized surface end-capping, ensuring resistance to aggressive IP-RP reagents. Its functionalized surface enables both strong reversed-phase interactions and controlled ionic contributions, effectively creating a mixed-mode separation mechanism. This design results in improved durability compared with standard mixed-mode columns, making Sepapure oliGO a robust choice for routine oligonucleotide workflows.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_Sepapure_oli_GO_columns_with_laser_etched_column_information_23f545be81.jpg" alt="KNAUER: Figure 1 - Sepapure oliGO columns with laser-etched column information." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_Sepapure_oli_GO_columns_with_laser_etched_column_information_23f545be81.jpg 223w," sizes="100vw" width="1186" height="828"><h3>Method Transfer and Comparative Performance</h3>In collaboration with BianoGMP GmbH, KNAUER’s application team evaluated Sepapure oliGO against a widely used reference column. The study compared oligonucleotides of varying lengths and purities, including a fully thiolated 43-mer DNA. Particular attention was paid to potential interactions between thiolated oligonucleotides and stainless-steel hardware, which have been reported to cause peak tailing.The results demonstrated that direct method transfer between the reference column and Sepapure oliGO was generally feasible without significant adjustment. Chromatographic resolution remained comparable, while retention times were slightly shorter on Sepapure oliGO. Furthermore, the anticipated benefits of expensive bioinert hardware were not confirmed under the tested conditions, suggesting that such effects may primarily influence very fast (U)HPLC separations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Overlayed_chromatogram_of_crude_product_of_a_43mer_thiolate_oligonucleotide_7ae9613efd.jpg" alt="KNAUER: Figure 2: Overlayed chromatogram of crude product of a 43mer thiolate oligonucleotide. Light blue - reference column and dark blue – Sepapure oliGO." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Overlayed_chromatogram_of_crude_product_of_a_43mer_thiolate_oligonucleotide_7ae9613efd.jpg 245w," sizes="100vw" width="1223" height="453"><h3>Low Backpressure for Reliable Operation</h3>Sepapure oliGO can be applied effectively in both HPLC and (U)HPLC workflows. Its low operating backpressure minimizes risks associated with clogging, excessive system wear, and performance deterioration over time. Typical IP-RP separations using 3 µm particles generated pressures around 200 bar, enabling laboratories without ultra-high-pressure systems to perform high-quality oligonucleotide analysis.<h3>Best Practices for Column Performance</h3>To maintain optimal performance, users should observe recommended operating conditions, including a broad pH range of 1.5–10 and temperatures up to 60 °C. Employing a guard column can prevent coarse synthesis by-products from reaching the analytical column. If pressure increases are observed, backflushing at low flow rates can restore performance.When the system is idle, thorough flushing to remove salts is essential. For storage, the column should be kept in a 1:1 mixture of methanol–water or acetonitrile–water. Gradient transitions are recommended when switching between standard RP eluents and IP-RP reagents. Regeneration procedures developed for RP columns are also suitable for Sepapure oliGO.<h3>Beyond Analytical Separations</h3>For large-scale purification, ion-exchange chromatography (AEX) may offer advantages. Scalable preparative systems are available to support purification workflows, ranging from compact laboratory setups to pilot-scale platforms with flow rates up to 800 mL/min. Bioinert configurations can be integrated where required, allowing laboratories to tailor purification solutions to their specific oligonucleotide applications.<blockquote><ul><li>If you're planning to set up or optimize your oligonucleotide workflow, feel free to contact us at sales@knauer.net. Stay tuned for more exciting insights into the Oligonucleotide world in our “Oligos Made Easy” series.</li><li>For more in-depth discussion or questions, reach out to the author at folmert@knauer.net&nbsp;</li></ul></blockquote>

Oligos Made Easy - Part 8: Sepapure oliGO

Visit the LabRulez booth at <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871">analytica 2026</a> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"><h3>Would you like to learn how the LabRulez portals work?</h3>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/">LabRulezLCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/">LabRulezGCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/">LabRulezICPMS</a><ul><li>A unique online solution for your marketing</li><li>A targeted audience from the analytical chemistry community</li><li>Modern technologies and a unique concept</li><li>Design optimized for most smart devices – PC, mobile, and tablet</li><li>Advanced statistical tools fully available to users</li></ul><h3>Services Offered</h3><h4>News + Company Updates</h4><ul><li>Publish news related to your instrumentation, applications, services, events, job openings, and more</li><li>News is shared both on our portals and across our social media channels</li></ul><h4>Library – All Documents in One Place</h4><ul><li>Applications, posters, presentations, technical articles, brochures, specifications</li><li>Fast and advanced search capabilities</li><li>Over 32,000 documents currently available in our database</li></ul><h4>Webinars</h4><ul><li>Upcoming and on-demand webinars from the field of analytical chemistry</li><li>More than 5,500 webinars covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4>Careers</h4><ul><li>Targeted job listings in analytical chemistry</li><li>Clear filtering by specialization or location</li><li>Increased visibility for job postings</li></ul><h4>Companies</h4><ul><li>Company profile with key information and contacts</li><li>Integration of all your activities on our portal: News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li>Connection to your Products listed on LabRulez portals</li></ul><h4>Products and Services</h4><ul><li>Comprehensive overview of instrumental techniques and services</li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4>Marketplace</h4><ul><li>Buying and selling pre-owned analytical equipment</li><li>We purchase analytical instrumentation of all brands and ages</li><li>Sell your equipment through LabRulez</li><li>Request and purchase complete systems, modules, or spare parts with warranty and service</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"><h3>What Will Be on Display at Our Booth?</h3>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar">LabRulezLCMS Marketplace</a></h4>Spare parts for LC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378">Vacuum turbo pumps for LC/MS</a></li></ul>Spare parts for HPLC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397">Degassers for HPLC/UHPLC</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve">Automatic valves for HPLC</a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377">HPLC lamps</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48">HPLC columns</a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar">LabRulezGCMS Marketplace</a></h4>Spare parts for GC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo">Turbo pumps for GC/MS</a></li></ul>Spare parts for GC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC">EPC modules</a></li></ul>Sample injection<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432">Autosampler 7693A for GC</a></li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7">GC columns </a>and selected accessories</li></ul>

LabRulez at analytica 2026

News from LabRulezLCMS Library - Week 13, 2026

Article

Product

Events

Application

Science and research

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Technology Networks

Bruker

Thermo Fisher Scientific

SelectScience

Listeria monocytogenes, a foodborne pathogen, poses a particular risk to vulnerable populations such as infants, the elderly, immunocompromised individuals, and pregnant women. Timely and accurate identification helps to prevent outbreaks of listeriosis and is essential for ensuring food safety and protection of public health.
In this webinar, Dr. Helene Oberreuter, food microbiologist and senior government councilor, will highlight a validated workflow for the differentiation of Listeria monocytogenes serogroups by FT-IR spectroscopy. The workflow consists of species identification by MALDI-TOF mass spectrometry (MALDI Biotyper®) followed by serogroup differentiation with the IR Biotyper® using a classifier which is based on an artificial neural network.
Key learning objectives
<ul>
<li>Explore the use of FT-IR spectroscopy in food pathogen detection
</li>
<li>Discover a validated workflow for serogroup differentiation
</li>
<li>Learn how to apply an artificial neural network to pathogen classification
</li>
<li>Gain insights into the preselection of samples by FT-IR for whole genome sequencing
</li>
</ul>
<blockquote>
Presenter: Dr. Helene Oberreuter (Food Microbiologist and Senior Government Councilor, CVUA Stuttgart, Germany)
</blockquote>
<blockquote>
Presenter: Lawrence Howes (SelectScience)
</blockquote>
Who should attend?
Those working in food microbiology laboratories, reference laboratories and centers for food pathogens, state and public health laboratories, and centers for disease control and prevention
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Bruker - Validated differentiation of Listeria monocytogenes by FT-IR spectroscopy using an artificial neural network based classifier

Validated differentiation of Listeria monocytogenes by FT-IR spectroscopy using an artificial neural network based classifier

Validated workflow for the differentiation of Listeria monocytogenes serogroups by FT-IR spectroscopy.

Differentiation of Listeria monocytogenes-FT-IR spectroscopy

MALDI Imaging allows for interrogation of the spatial distribution of metabolites and lipids in tissue, as well as expanding targeted analysis to small molecules, glycans, and targeted proteins. Recent technical developments enable imaging for maximum biological information at robust (sub)cellular resolution. However, imaging entire tissue sections with high spatial resolution entails large number of pixels and requires extensive acquisition times. Thus, researchers are seeking for alternative high-speed chemical imaging techniques, which are conducted prior to MALDI Imaging to narrow down the regions of interest (ROIs) on large sample areas. Infrared Laser Imaging (ILIM) allows non-destructive, label free biochemical imaging of complete tissue sections within minutes – thus represents the ideal complementary analytical tool to make MALDI Imaging faster and smarter.
Webinar Overview
This webinar will introduce how breakthrough IR Laser Imaging performance is combined with best-in-class MALDI Imaging. Bruker’s new end-to-end workflow for IR Guided MALDI Imaging enhances sample throughput and provides increased analytical depth by offering maximized spatial resolution and collision cross section (CCS)-enabled label analysis for large-scale MALDI Imaging studies in biological and pharmaceutical research.
What to Expect:
Live presentation from Bruker’s experts to see the how tissue imaging has become faster than ever, the seamless integration of Infrared Laser Imaging (ILIM) into existing MALDI Imaging workflows and highlighting user stories, how IR Guided MALDI Imaging paves the way for deeper spatial multiomics of complex biological systems.
Who Should Attend:
<ul>
<li>MALDI Imaging users wanting to expand their workflows for increased sample throughput and analytical depth.</li>
<li>Scientists &amp; researchers interested in conducting multimodal imaging approaches for increased biological insight.</li>
<li>Anyone interested in learning more about Infrared Laser Imaging and MALDI Imaging capabilities.</li>
</ul>
<blockquote>
Presenter: Wojciech Kazmierski ( Country Manager, Bruker Optics, Poznan, Poland)
</blockquote>
<blockquote>
Presenter: Arne Behrens, Ph.D. (Application Scientist Imaging, Bruker Daltonics, Bremen, Germany)
</blockquote>
<blockquote>
Presenter: Domenic Dreisbach (Business Development Multimodal Imaging, Bruker Optics, Ettlingen, Germany)
</blockquote>

Bruker: Make MALDI Imaging faster and smarter with Infrared Laser Imaging

Make MALDI Imaging faster and smarter with Infrared Laser Imaging

IR Laser Imaging combined with best-in-class MALDI Imaging.

MALDI Imaging with Infrared Laser Imaging

<h4>Bruker LabCast Part I</h4>
<a href="https://lcms.labrulez.com/webinar/4126">Part II</a>
Learn about MALDI Imaging with neofleX™, the newest benchtop mass spectrometer from Bruker. From entry-level researchers to experienced mass spectrometry users, this instrument will help you accomplish your research goals. The continued innovation of neofleX™ brings together intuitive software, and modern hardware for seamless automation and use for all users. Depth of analysis and fast results are not compromised in this benchtop system.
During this webinar, you&#39;ll learn:
<ul>
<li>The multiomics capabilities of MALDI Imaging</li>
<li>Ease-of-use on a benchtop mass spectrometer</li>
<li>Analytical figures of merit of the neofleX™</li>
</ul>
Who should attend:
<ul>
<li>Researchers interested in expanding their spatial biology toolkit</li>
<li>Researchers who want translational research tools</li>
<li>Anyone who wants to expand their instrument knowledge</li>
<li>Researchers focused on maximizing multiomics capabilites</li>
</ul>
<blockquote>
Presenter: Joshua Fischer, Ph.D., (Imaging Applications Scientist, Bruker Scientific, Nashua, NH, USA)
</blockquote>
<blockquote>
Dr. Joshua Fischer is an Application Scientist at Bruker focusing on MALDI Imaging. Dr. Fischer completed his Ph.D. at Purdue University and is an expert on MALDI Imaging and MALDI-FT-ICR systems.
</blockquote>
<blockquote>
Presenter: Daniel Castro, Ph.D., (Imaging Application Scientist, Bruker Scientific, Billerica, MA, USA)
</blockquote>
<blockquote>
Dr. Daniel Castro is an Application Scientist at Bruker focusing on MALDI Imaging. Dr. Castro completed his Ph.D. at the University of Illinois-Urbana-Champaign, and is an expert in high-throughput MALDI measurements and MALDI Imaging.
</blockquote>
<blockquote>
Presenter: Kate Stumpo, Ph.D., (Senior Market Manager, Bruker Scientific, Billerica, MA, USA)
</blockquote>
<blockquote>
Dr. Kate Stumpo is a Market Manager which entails messaging and marketing for MALDI Imaging. Dr. Stumpo completed her Ph.D. at Texas A&amp;M University, and is an expert in MALDI applications, including MALDI Imaging.
</blockquote>

Bruker: A complete imaging solution with automated workflows using neofleX™

A complete imaging solution with automated workflows using neofleX™

Learn about MALDI Imaging with neofleX™, the newest benchtop mass spectrometer from Bruker.

Imaging solution with automated workflows using neofleX™

At ASMS 2024, Bruker&#39;s Life Science division unveiled a range of cutting-edge products, including the timsTOF Ultra 2 with significant increases in sensitivity for deep proteome analysis. Additionally, the new neofleX™ MALDI-TOF benchtop system was showcased, offering improved sensitivity and accuracy for proteomics and metabolomics research with automated workflow using SCiLS™ autopilot. The new OmniScape™ and Bruker ProteoScape™ software solutions are being highlighted for their advanced data analysis capabilities. OmniScape improves the speed and quality of annotations for top-down sequencing, while Bruker ProteoScape™ now includes the Spectronaut® core module for directDIA+ workflows. Additionally, the Bruker ProteoScape™ package includes GlycoScape™, a real-time glycopeptide analysis workflow.
Key Learnings:
<ul>
<li>timsTOF Ultra 2 for unmatched robustness, unparalleled duty cycle, and single-cell sensitivity</li>
<li>Analytical merits, and applications of the new benchtop MALDI-TOF neofleX™</li>
<li>Multiomics capabilities of MALDI Imaging</li>
<li>OmniScape™ improves the speed and quality of annotations for top-down spectra</li>
<li>Bruker ProteoScape™ Package includes the Spectronaut core module for directDIA+ workflows</li>
<li>GlycoScape™ - a real-time glycopeptide analysis workflow - will be included in the Bruker ProteoScape™ package </li>
<li>MetaboScape® - All-in-one software solution for compound identification in small molecule research</li>
</ul>
<blockquote>
Presenter: Adam Rainczuk, Application Specialist
</blockquote>
<blockquote>
Presenter: Tosapol (Paul) Anukunwithaya, Application Specialist
</blockquote>
<blockquote>
Presenter: Wen Donq (Gaelin) Looi, Application Specialist
</blockquote>

Bruker: Advancing Multiomics, Biopharma, and MS Imaging - Latest MS Technologies 

Advancing Multiomics, Biopharma, and MS Imaging - Latest MS Technologies 

Bruker unveiled a range of cutting-edge products, including the timsTOF Ultra 2 for deep proteome analysis.

Multiomics, Biopharma, and MS Imaging - Latest MS Tech

Analytik Jena and Bruker have collaborated to bridge the gap between mass spectrometry’s powerful, label-free detection capabilities and modular automated uHTS sample preparation.
Join Dr. Christian Klinner, Analytik Jena, Arndt Asperger, Bruker Daltonics, Amanda Weaver, Biodesix, and Kahler Pascuale Bugtong, Aether Biomachines as they discuss how the CyBio Well Vario pipetting device by Analytik Jena enhances MALDI spotting and sample optimization, seamlessly integrating with Bruker MS solutions to overcome application-specific bottlenecks.
Key learning objectives
<ul>
<li>Learn how to increase your MALDI throughput, MALDI spotting of 1536 samples in &lt;10 minutes</li>
<li>Discover how to successfully overcome hardware, software and labware challenges</li>
<li>Gain insights into a walk away automation solution for MALDI-TOF-MS</li>
</ul>
Who should attend?
Users looking to automate their MALDI-TOF sample prep
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
<blockquote>
Presenter: Christian Klinner, PhD (Application specialist for the liquid handling &amp; automation, Business Segment – Life Science Solution, Analytik Jena GmbH+Co. KG)
</blockquote>
<blockquote>
Dr. Christian Klinner received his PhD in Natural Sciences from the Friedrich-Schiller University Jena. He joined Analytik Jena GmbH+Co. KG in 2017, and is responsible for the applicative support for the liquid handling devices in the business segment life science solution.
</blockquote>
<blockquote>
Presenter: Arndt Asperger, PhD (Senior applications scientist, Bruker Daltonics GmbH &amp; Co. KG)
</blockquote>
<blockquote>
Dr. Arndt Asperger is a senior applications scientist at Bruker Daltonics GmbH &amp; Co. KG, Bremen, Germany. He is an analytical chemist by training, and received his PhD from Leipzig University. Asperger joined Bruker in 2002 and has been working in various positions related to MALDI-MS applications and applications development.
</blockquote>
<blockquote>
Presenter: Amanda Weaver (Senior scientist in applied research and technology, Biodesix)
</blockquote>
<blockquote>
Amanda Weaver is a senior scientist in the applied research and technology group in the Biodesix corporate laboratory in Colorado. Her training has been focused in the regulated laboratory on automation, new methods evaluation, tests and assays developed on the MALDI-ToF and QQQ mass spectrometers, ddPCR, and NGS platforms. Currently, her key responsibilities are in early technology assessment and assay feasibility, verification, and validation, as well as external collaborator projects.
</blockquote>
<blockquote>
Presenter: Kahler Pascuale (K.P.) Bugtong (Senior automation engineer, Aether Biomachines)
</blockquote>
<blockquote>
Kahler Pascuale (K.P.) Bugtong has more than 10 years of experience in molecular biology, having worked at several biotech and clinical diagnostics companies. Before transitioning to automation, he worked at the bench, contributing to diverse projects such as NGS and ELISA assay development, and the manufacturing of DNA microarrays. At Aether, Bugtong is a senior automation engineer, responsible for supporting Aether’s laboratory automation efforts.
</blockquote>
<blockquote>
Moderator: Carrie Haslam (Associate Editor, SelectScience)
</blockquote>

SelectScience: Revolutionize drug discovery with high throughput mass spectrometry and automated pipetting

Revolutionize drug discovery with high throughput mass spectrometry and automated pipetting

The CyBio Well Vario pipetting by Analytik Jena enhances MALDI spotting and sample optimization with Bruker MS solutions.

Drug discovery with HTS MS and automated pipetting

MALDI mass spectrometry imaging has emerged as a powerful technology platform for spatially resolved analysis and visualization of a wide range of molecules – including drugs, metabolites, peptides and more – in pharmaceutical R&amp;D, clinical research and basic science. Advances in MALDI workflows are making the technique more accessible.
In this webinar, our speaker will discuss how new MALDI workflows can be used to analyze lipids in degenerative disease and Alzheimer’s models, providing more depth to lipid analysis and contextualizing lipid distribution by enabling comparison to multiple protein markers. He’ll also highlight how the new workflow can be applied to the study of tumor subtypes and the tumor microenvironment.
Attend this webinar to:
<ul>
<li>Explore the multiomics applications of spatial mass spectrometry – from cancer research to understanding neurodegeneration</li>
<li>Discover how MALDI mass spectrometry imaging is becoming more accessible</li>
<li>Learn how to apply the simplified MALDI imaging workflow to your research</li>
</ul>
<blockquote>
Presenter: Prof. Dr. Carsten Hopf (Head of the Center of Mass Spectrometry and Optical Spectroscopy at Mannheim Technical University)
</blockquote>
<blockquote>
Carsten Hopf obtained his PhD in biochemistry from Tübingen University/Max-Planck-Institute for Developmental Biology. As an EMBO fellow in neuroscience, he then worked at the Johns Hopkins University School of Medicine for three years, before joining Cellzome AG, a proteomics-focused drug discovery platform company in Heidelberg in 2001. There, for 13 years, he served in multiple roles in platform technology, assay development, drug discovery and business development, and eventually as part of Cellzome’s leadership team till 2014. Since 2005, Carsten Hopf is a professor of bioanalytics, proteomics and drug discovery at Mannheim University of Applied Sciences. He currently heads the Center of Mass Spectrometry and Optical Spectroscopy (CeMOS) as well as the M2Aind partnership for innovation in health industry in Mannheim, and he serves on boards of biomedical clusters. He is also an associated professor in the Medical and Biosciences Faculties of Heidelberg University and co-chair for “imaging” of the German Society for MS (DGMS).
</blockquote>

Technology Networks: Applying Spatial Multiomics to Degenerative Diseases and Cancer

Applying Spatial Multiomics to Degenerative Diseases and Cancer

Our speaker will discuss how new MALDI workflows can be used to analyze lipids in degenerative disease and Alzheimer’s models.

Spatial Multiomics in Degenerative Diseases and Cancer

<h4>Rebroadcast of the Live from the Lab: Solutions for Multi-Omics Research from June 13, 2024</h4>
Single-cell spatial metabolomics and lipidomics using AP-SMALDI and Orbitrap technology
In this session, Max A. Müller (TransMIT GmbH) discusses the importance of investigating single cells using mass spectrometry imaging. He explains how single cells come in various shapes and sizes, and how studying them at a bulk level may not provide accurate insights due to differences between cell phenotypes. Mass spectrometry imaging allows for high-resolution analysis, capturing the intricate details of single cells.
Max delves into the technical aspects of mass spectrometry imaging, including the use of a specialized objective lens and the importance of high lateral resolution and mass resolving power. He showcases several examples, such as investigating schistosomiasis and its impact on liver tissue, exploring the biochemical processes of apoptosis in intestinal organoids, and analyzing microglial cells in the central nervous system.
Don&#39;t miss this opportunity to learn from Max&#39;s expertise and gain insights into the cutting-edge field of mass spectrometry imaging.
Can&#39;t attend the webinar broadcast? No problem! Register anyway and you will automatically receive the link to the recording.
<blockquote>
Presenter: Dr. Max A. Müller (TransMIT GmbH)
</blockquote>

Thermo Fisher Scientific: Single-cell spatial metabolomics and lipidomics using AP-SMALDI and Orbitrap technology

Single-cell spatial metabolomics and lipidomics using AP-SMALDI and Orbitrap technology

Single-cell spatial metabolomics and lipidomics

Multiomic and multimodal spatial data from one tissue sample provides actionable information for disease related insights.
Leverage mass spectrometry in the post-genomic era to move beyond the biological determinants of DNA and RNA.Contextualize biological information with proteins and downstream molecules using an innovative benchtop system optimized for ease-of-use.
During this webinar, you will learn:
<ul>
<li>The multiomics capabilities of MALDI Imaging
</li>
<li>The benefits of spatial biology for disease based research
</li>
<li>Ease-of-use of neofleX, a benchtop mass spectrometer for spatial biology
</li>
</ul>
Who should attend:
<ul>
<li>Translational researchers who want advanced spatial biology tools with ease-of-use workflows
</li>
<li>Researchers focused on maximizing spatial multiomics capabilites
</li>
<li>Anyone interested in benchtop mass spectrometers with no compromise on quality register here
</li>
</ul>
<blockquote>
Presenter: Mengzhe Zhang, Ph.D. Candidate, Bernd Bodenmiller Lab, University of Zurich, Zurich, Switzerland
</blockquote>
<blockquote>
Presenter: Janina Oetjen, Ph.D., Imaging Applications Scientist, Bruker Daltonics, Bremen, Germany
</blockquote>
<blockquote>
Presenter: Kate Stumpo, Ph.D., Senior Market Manager, Bruker Scientific, Billerica, MA, USA
</blockquote>

Bruker:  LabCast: Spatial profiling to transform molecular pathway awareness using neofleX

 LabCast: Spatial profiling to transform molecular pathway awareness using neofleX

The multiomics capabilities of MALDI Imaging.

 LabCast: Spatial profiling to transform molecular pathway

MALDI Top-Down Sequencing (MALDI-TDS) delivers N- and C-terminal sequence readout for intact proteins or protein subunits within minutes.
Leverage the novel neofleX™ MALDI-TDS workflow for verification of therapeutic antibodies, antigens and other protein expression products regarding sequence, terminal status and modifications and, thereby, enable instant decision making in strain development and production in biopharma or other branches of industry.
During this webinar, you will learn:
<ul>
<li>Overview of neofleX technology and its benefits to life sciences applications
</li>
<li>neofleX top-down workflow: Protein sequence verification with shortest time-to-result
</li>
<li>OmniScape™ software: From data to sequencing results with just a few mouse clicks
</li>
</ul>
Who should attend:
<ul>
<li>Characterization team leaders in biopharma companies and CROs
</li>
<li>Mass spectrometry core lab managers
</li>
<li>Researchers who are interested in fast protein characterization methods
</li>
<li>Anyone who needs to deliver instant sequence verification for protein expression products
</li>
<li>Anyone who would like to learn about the latest MALDI-TOF/TOF technology
</li>
</ul>
<blockquote>
Presenter: Jan Hendrik Kobarg, Ph.D. (Product Manager, MALDI-TOF, Bruker Daltonics, Bremen, Germany)
</blockquote>
<blockquote>
Jan Kobarg, Ph.D., is the product manager for the MALDI-TOF instrument portfolio at Bruker. The latest addition to the portfolio is the neofleX™ MALDI-TOF Benchtop instrument.
</blockquote>
<blockquote>
Presenter: Arndt Asperger, Ph.D. (Senior Applications Scientist, Bruker Daltonics, Bremen, Germany)
</blockquote>
<blockquote>
Arndt is analytical chemist by training and got his Ph.D. from Leipzig University. He joined Bruker in 2002 and has been working in various application related positions with a focus on pharma/biopharma.
</blockquote>

Bruker: LabCast: Simple and fast top-down protein characterization using neofleX benchtop MALDI-TOF/TOF

LabCast: Simple and fast top-down protein characterization using neofleX benchtop MALDI-TOF/TOF

Overview of neofleX technology and its benefits to life sciences applications.

LabCast: Simple and fast top-down protein characterization

Fragmentation-based molecular annotations are the gold standard in high-confidence biomarker identification using mass spectrometry.
The new iprm-PASEF workflow integrates CCS-enabled MALDI Imaging of lipids with a targeted MS/MS imaging approach that allows spatial fragmentation and analysis of multiple targets in a single acquisition. The workflow includes a fully integrated pipeline within our software ecosystem to generate accurate identifications with spatial fidelity.
Key Learning Objectives:
<ul>
<li>Fragmentation based MALDI Imaging capabilities
</li>
<li>iprm-PASEF workflow for the timsTOF fleX
</li>
<li>Fragmentation based annotation pipeline using SCiLS™ Lab
</li>
</ul>
Who should attend:
<ul>
<li>Researchers interested in expanding their spatial biology toolkit
</li>
<li>Researchers focused on maximizing confidence of molecular annotations for MALDI Imaging
</li>
<li>Anyone who wants to expand their MALDI Imaging workflows
</li>
</ul>
<blockquote>
Presenter: Michael Becker, Ph.D. (Principal Scientist DMPK, Boehringer Ingelheim Pharma GmbH &amp; Co KG, Mainz, Germany)
</blockquote>
<blockquote>
Dr. Michael Becker is the head of the Mass Spectrometry Imaging lab at Boehringer Ingelheim. He received his Ph.D. in Neurobiology, and transitioned into the imaging field more than 15 years ago. He uses MSI to study drugs and drug-induced changes in tissue. To do so, he tries to push the sensitivity, reproducibility and specificity of the method.
</blockquote>
<blockquote>
Presenter: Arne Behrens, Ph.D. (Application Specialist in MALDI Imaging, Bruker Daltonics GmbH &amp; Co. KG, Bremen, Germany)
</blockquote>
<blockquote>
Dr. Arne Behrens is an Imaging Applications Scientist  at Bruker in Bremen with more than 6 years of experience on the timsTOF fleX platform. He received his Ph.D. in Analytical Chemistry and is an expert for CCS-enabled MALDI Imaging applications.
</blockquote>
<blockquote>
Presenter: Björn Wendik, Ph.D. (Business Development Manager, Bruker Daltonics GmbH &amp; Co. KG, Bremen, Germany)
</blockquote>
<blockquote>
Björn studied biology at the University of Würzburg and University of Freiburg with focus on developmental biology. In Freiburg he did his Ph.D. working on motoneuron development and pancreas formation. He became an expert on life cell imaging, timelapse studies and 3d-image software analyses. He continued his work as lecturer at the University of Freiburg where he also took care of parts of the Imaging core facility. When stepping into industry, he worked as a specialist for confocal microscopy and from there moved on into multispectral imaging, antibody based multi- and hiplexing and tissue analysis platforms. With this expertise, Björn started as a Business Development Manager for the MALDI Imaging at Bruker in July 2023.
</blockquote>

Bruker: Confidence in spatial identifications using iprm-PASEF on the timsTOF fleX

Confidence in spatial identifications using iprm-PASEF on the timsTOF fleX

The new iprm-PASEF workflow integrates CCS-enabled MALDI Imaging of lipids with a targeted MS/MS imaging approach.

LCMS webinars focusing on MALDI - page 3