<p><strong>The human body is the most sophisticated atomic engineer. This idea underpins a breakthrough technology developed by an international research team led by scientists from the Czech Advanced Technology and Research Institute (CATRIN) at Palacký University Olomouc and the Centre for Energy and Environmental Technologies (CEET) at VSB – Technical University of Ostrava. By drawing inspiration from the way enzymes function in the human body, the researchers have created a novel material that could fundamentally change the industrial production of hydrogen peroxide and other important chemicals. The new approach simplifies the production process, eliminates the need for toxic organic solvents and expensive precious metals, and requires only sunlight, oxygen and water to operate. The results </strong><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-025-67189-3"><strong>were published by the prestigious journal </strong><i><strong>Nature Communications</strong></i></a><strong>, which ranked the study among the 50 most significant scientific discoveries of the year.</strong></p><p>Hydrogen peroxide is one of the most important industrial chemicals. It is widely used not only in the chemical industry but also in pharmaceuticals, medicine, the textile industry and water-treatment technologies. The global hydrogen peroxide market is estimated to exceed USD 5 billion annually. Conventional production involves a multistep process that relies on toxic organic solvents and costly palladium-based catalysts. In addition, both the starting chemicals and the resulting waste products can have negative impacts on human health and the environment.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Cesti_vedci_vyvinuli_material_pro_vyrobu_chemikalii_z_vody_a_slunce_Inspirovali_se_lidskymi_enzymy_2_c4d5ecbafb.webp" alt="CATRIN: Czech scientists develop a material for producing chemicals from water and sunlight, inspired by human enzymes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Cesti_vedci_vyvinuli_material_pro_vyrobu_chemikalii_z_vody_a_slunce_Inspirovali_se_lidskymi_enzymy_2_c4d5ecbafb.webp 208w," sizes="100vw" width="1600" height="1200"></p><p><i>“Our aim was to develop a material that enables the efficient, environmentally friendly and affordable production of hydrogen peroxide. When designing this photocatalyst, we were inspired by the structure and behaviour of enzymes in the human body. The result is a technology that does not require toxic organic solvents or expensive precious metals and instead uses a low-cost material based on carbon, nitrogen and copper. It operates in water using only sunlight and oxygen from the air,”</i> said<strong> Radek Zbořil, leader of research teams at CATRIN and CEET</strong>.</p><p>In developing the new photocatalyst, the Czech scientists mimicked the function of cytochrome c oxidase—an enzyme that enables human cells to obtain energy by transferring electrons to oxygen. This process relies on copper atoms embedded in the enzyme’s structure, and it was precisely this mechanism that the researchers sought to reproduce.</p><p><i>“We very precisely replicated the chemical environment of metals within the enzyme’s structure and anchored copper atoms onto the surface of extremely small carbon nanoparticles with photocatalytic properties. When exposed to light, highly efficient electron transfer occurs between the carbon nanoparticles, the copper atoms and oxygen molecules. This process closely resembles an enzymatic reaction and enables high hydrogen peroxide production,”</i> explained the first author of the study, <strong>Lukáš Zdražil, who is affiliated with both CATRIN and CEET</strong>.</p><p>Producing hydrogen peroxide using sunlight and water has been a long-standing goal of research teams worldwide, as it eliminates the use of toxic organic solvents and avoids the formation of hazardous by-products. Until now, however, research in this area has largely remained at an academic level, mainly due to the use of noble metals and often complex photocatalyst designs. Laboratory studies have also resulted in relatively low hydrogen peroxide yields, which could not compete with existing industrial processes.</p><p><i>“<strong>The new photocatalyst achieves hydrogen peroxide production rates up to two orders of magnitude higher than all previously reported systems</strong>, bringing us much closer to industrial requirements. In addition, the material is completely non-toxic, easily recyclable and reusable,”</i> added Zdražil.</p><p>The Czech teams are now focusing on potential applications of this technology in decentralised production units. Such systems could enable efficient, local production of hydrogen peroxide, for example for use in agriculture, pharmaceutical manufacturing or environmental applications. The combination of solar energy and materials inspired by enzymatic systems may also lead to further promising advances.</p><p><i>“I believe that mimicking the structures and functions of iron- and copper-based enzymes could pave the way for other innovative technologies in the chemical industry and pharmaceuticals, such as the production of epoxides, alcohols or phenols,”</i> concluded Zbořil.</p>

 Czech scientists develop a material for producing chemicals from water and sunlight, inspired by human enzymes

<h3><strong>Mastering Ion-Pair Reversed-Phase Chromatography for Oligonucleotide Analysis</strong></h3><h4><strong>Why Purity Is Critical in the Oligonucleotide Era</strong></h4><p>Oligonucleotides — short, synthetic strands of DNA or RNA — are central to modern biotechnology. They power gene therapies, advanced diagnostics, and cutting-edge molecular research. However, before these molecules can be used in clinical or research settings, their purity and structural integrity must be thoroughly verified. High-resolution chromatographic analysis plays a crucial role in ensuring quality and safety.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_Separation_Example_of_Oligonucleotides_5577514561.jpg" alt="KNAUER: Figure 1 - Separation Example of Oligonucleotides." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_Separation_Example_of_Oligonucleotides_5577514561.jpg 245w," sizes="100vw" width="1024" height="368"></p><h4><strong>Understanding Ion-Pair Reversed-Phase (IP-RP) Chromatography</strong></h4><p>For scientists involved in oligonucleotide synthesis and characterization, Ion-Pair Reversed-Phase Chromatography (IP-RP) is one of the most effective analytical tools available.</p><p>Unlike separation techniques that rely solely on charge differences, IP-RP combines:</p><ul><li>Ionic interactions</li><li>Hydrophobic interactions</li></ul><p>This dual retention mechanism enables exceptional resolution — even for oligonucleotides that differ by only a single nucleotide or subtle chemical modification. Whether assessing synthesis efficiency or purifying therapeutic-grade material, IP-RP provides reliable, reproducible separations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Overview_of_IP_RP_Mode_prinicple_ecd54b6e9c.jpg" alt="KNAUER: Figure 2 - Overview of IP-RP Mode prinicple." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Overview_of_IP_RP_Mode_prinicple_ecd54b6e9c.jpg 245w," sizes="100vw" width="1024" height="456"></p><h4><strong>The Principle Behind Ion-Pairing</strong></h4><p>Oligonucleotides possess a highly negatively charged phosphate backbone. In a traditional reversed-phase system, such hydrophilic, charged molecules would show little retention.</p><p>IP-RP overcomes this limitation by introducing a positively charged ion-pairing reagent into the mobile phase. The cation associates with the negatively charged oligonucleotide, forming a transient ion pair with increased hydrophobic character. This modified complex can now interact with the hydrophobic stationary phase.</p><p>Retention strength depends on:</p><ul><li>The hydrophobicity of the ion-pair reagent</li><li>The strength of ionic interaction</li><li>The applied organic gradient</li></ul><p>During gradient elution (commonly using acetonitrile), analytes are released in a controlled manner according to size, sequence, and chemical modifications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_Ion_Pair_Reversed_Phase_Principle_9a4fcd12f2.jpg" alt="KNAUER: Figure 3 - Ion-Pair Reversed Phase Principle." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_Ion_Pair_Reversed_Phase_Principle_9a4fcd12f2.jpg 245w," sizes="100vw" width="1024" height="393"></p><h4><strong>Choosing the Right Ion-Pair Reagent</strong></h4><p>Successful IP-RP separation depends heavily on selecting an appropriate ion-pair reagent. Two key factors determine retention behavior:</p><ol><li>Alkyl chain length</li><li>Charge density</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_4_Ion_Pair_Classification_eaad172a4e.jpg" alt="KNAUER: Figure 4 - Ion-Pair Classification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_4_Ion_Pair_Classification_eaad172a4e.jpg 245w," sizes="100vw" width="1024" height="398"></p><h4><strong>Strong Cationic Ion-Pair Reagents</strong></h4><p>Ion-pair reagents with longer alkyl chains provide stronger hydrophobic interactions and increased retention. A widely used example is tetrabutylammonium (TBA⁺), frequently applied for strongly retained anionic analytes.</p><p>These reagents are particularly useful when high retention strength is required.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Table_1_Strong_Cationic_Ion_Pair_Reagents_8dbf00c57e.jpg" alt="KNAUER: Table 1 - Strong Cationic Ion-Pair Reagents." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Table_1_Strong_Cationic_Ion_Pair_Reagents_8dbf00c57e.jpg 245w," sizes="100vw" width="1024" height="396"></p><h4><strong>Volatile (Weaker) Ion-Pair Reagents</strong></h4><p>Short-chain ion-pair reagents generate weaker retention but offer a significant advantage: compatibility with LC–MS detection.</p><p>Triethylammonium (TEA⁺) is among the most commonly used reagents for oligonucleotide analysis, particularly when mass spectrometric detection is involved. Other options, such as diisopropylethylammonium (DIEA⁺), are also widely applied, often combined with HFIP to enhance MS performance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Table_2_Weak_Cationic_Ion_Pair_Reagents_6332a4975e.jpg" alt="KNAUER: Table 2 - Weak Cationic Ion-Pair Reagents." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Table_2_Weak_Cationic_Ion_Pair_Reagents_6332a4975e.jpg 245w," sizes="100vw" width="1024" height="283"></p><h4><strong>Building an IP-RP Method for Oligonucleotides</strong></h4><p>Developing a robust IP-RP method follows a logical sequence:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Table_3_IP_RP_Method_Step_Procedure_for_Oligos_c2216c24a0.jpg" alt="KNAUER: Table 3 - IP-RP Method Step Procedure for Oligos." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Table_3_IP_RP_Method_Step_Procedure_for_Oligos_c2216c24a0.jpg 245w," sizes="100vw" width="1024" height="304"></p><h5><strong>1. Characterize the Analyte</strong></h5><p>Oligonucleotides typically contain 10–50+ nucleotides and exhibit high negative charge density. This necessitates a suitable cationic partner such as TEA⁺ or DIEA⁺.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_5_Cationic_Ion_Pair_Principle_for_Oligonucleotides_cb2dfb7457.jpg" alt="KNAUER: Figure 5 - Cationic Ion-Pair Principle for Oligonucleotides." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_5_Cationic_Ion_Pair_Principle_for_Oligonucleotides_cb2dfb7457.jpg 245w," sizes="100vw" width="512" height="320"></p><h5><strong>2. Select the Column</strong></h5><p>Use a reversed-phase column with:</p><ul><li>Large pore size (≈300 Å)</li><li>Appropriate internal diameter</li></ul><p>These parameters support the so-called “ON–OFF” retention mechanism — a bind-and-elute behavior where analytes are strongly retained until the gradient triggers rapid elution.</p><h5><strong>3. Optimize the Mobile Phase</strong></h5><p>A typical starting condition includes:</p><ul><li>10 mM TEA buffer at pH ~7</li><li>Acetonitrile as organic modifier</li></ul><p>Gradient programs from approximately 5% to 50% organic solvent over 15–30 minutes are commonly effective for complex oligonucleotide mixtures.</p><h5><strong>4. Adjust Retention Strength if Needed</strong></h5><p>To increase retention:</p><ul><li>Raise ion-pair concentration (up to ~100 mM if required)</li><li>Select a more hydrophobic ion-pair reagent</li></ul><h5><strong>5. Validate the Method</strong></h5><p>Ensure robustness, sensitivity, and reproducibility by carefully evaluating:</p><ul><li>UV chromatograms</li><li>MS traces</li><li>Peak shape and resolution</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_6_UV_MS_traces_of_IP_RP_Oligonucleotide_Analysis_81faf4e9f0.jpg" alt="KNAUER: Figure 6 - UV-MS traces of IP-RP Oligonucleotide Analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_6_UV_MS_traces_of_IP_RP_Oligonucleotide_Analysis_81faf4e9f0.jpg 245w," sizes="100vw" width="1024" height="365"></p><h4><strong>Why IP-RP Is Considered the Gold Standard</strong></h4><p>Ion-Pair Reversed-Phase Chromatography uniquely combines the resolving power of reversed-phase LC with the ability to retain highly polar, charged biomolecules.</p><p>Its advantages include:</p><ul><li>Tunable selectivity</li><li>Compatibility with UV and MS detection</li><li>Scalability from analytical to preparative workflows</li><li>Applicability from research to pharmaceutical production</li></ul><p>By transforming highly charged oligonucleotides into hydrophobic ion-pair complexes, IP-RP enables precise and reproducible separations that would otherwise be impossible in conventional reversed-phase systems.</p><p>For these reasons, IP-RP is widely regarded as the benchmark technique for oligonucleotide analysis.</p><h4><strong>Final Thoughts</strong></h4><p>Mastering IP-RP is less intimidating than it may seem. A successful method comes down to:</p><ul><li>Selecting the right ion-pair reagent</li><li>Choosing a suitable column</li><li>Optimizing gradient conditions</li><li>Fine-tuning temperature and concentration parameters</li></ul><p>With thoughtful method development, IP-RP delivers sharp peaks, clean separations, and reliable performance — fully compatible with modern mass spectrometry workflows and ready to meet the demands of advanced oligonucleotide analysis.</p>

Oligos Made Easy - Part 3: IP-RP

<h4><strong>"Education is central to how I approach research"</strong></h4><p><strong>Analytical scientist Dr Bob Pirok of the Van ‘t Hoff Institute for Molecular Sciences has been awarded the 19th annual ‘Emerging Leader in Chromatography Award’ by LCGC International, a well-known global publisher in the field of separation science. Pirok will receive the award at the upcoming Pittcon 2026 conference held 7-11 March in San Antonio, Texas.</strong></p><p>With the Emerging Leader in Chromatography Award, LGCG International recognises the achievements and aspirations of talented early-career separation scientists who have made strides toward the advancement and applications of chromatography techniques. Pirok is honoured for his work in the <strong>development of comprehensive two-dimensional liquid chromatography (LC×LC), automated method development, and chemometric data analysis</strong>.</p><p>Already in his early career, Pirok has emerged as a prominent figure in addressing long-standing challenges in LC×LC, which include method complexity, data interpretation, and experimental optimisation. His research is characterised by close interaction between theory, instrumentation, and application, as well as sustained collaboration with academic and industrial partners. On a mission to transform advanced chromatographic techniques into practical and robust analytical tools, Pirok has <strong>authored or co-authored more than 50 peer-reviewed publications</strong> and established an internationally visible research program at the interface of separation science, statistics, and artificial intelligence. All this within a few years of receiving his PhD in 2019.</p><h4><strong>Automated method development</strong></h4><p>Central to Pirok’s research is the novel <strong>modular AutoLC platform</strong>, which enables prototype automated method development. With a capacity to run unsupervised (i.e. without human input), it is able to tackle samples of unknown composition by autonomous analysis of <strong>(2D-)LC(-MS) data</strong>. It is flexible, able to support different optimization strategies and capable of integrating tools developed by scientists in the global chromatographic community.</p><p>Accessibility and sustainability are key motivations behind AutoLC, says Pirok: “<i><strong>State-of-the-art separation technology is often overly sophisticated. We aim to make it more robust, automated, and usable beyond a small group of specialists, as efficiently as possible. By providing more detailed and reliable molecular information, such technologies can better inform molecular design and accelerate the development of new materials and applications.</strong></i>”</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HIMS_From_left_to_right_Bob_Pirok_Prof_Peter_Schoenmakers_Ph_D_candidate_Gerben_van_Henten_and_postdoc_researcher_Tijmen_Bos_in_the_Auto_LC_lab_at_the_Van_t_Hoff_Institute_for_Molecular_Sciences_a4fe9bc6f7.jpg" alt="HIMS: From left to right: Bob Pirok, Prof. Peter Schoenmakers, PhD candidate Gerben van Henten, and postdoc researcher Tijmen Bos in the AutoLC lab at the Van ‘t Hoff Institute for Molecular Sciences. The AutoLC workflow builds on concepts originally introduced by Schoenmakers in 1978, which have now been adapted and extended within a modern, automated framework by the AutoLC team. Schoenmakers, who retired in 2022, was awarded the 2023 LCGC Lifetime Achievement Award." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HIMS_From_left_to_right_Bob_Pirok_Prof_Peter_Schoenmakers_Ph_D_candidate_Gerben_van_Henten_and_postdoc_researcher_Tijmen_Bos_in_the_Auto_LC_lab_at_the_Van_t_Hoff_Institute_for_Molecular_Sciences_a4fe9bc6f7.jpg 245w," sizes="100vw" width="700" height="425"></p><p>He is especially grateful to his students who continuously challenge assumptions and push the technology further. “<i>They show why research and education belong together</i>”, he says. “<i>In fact, education is central to how I approach research. Many of the ideas behind AutoLC grew directly from discussions with students, in the lab, in courses, or while trying to explain complex concepts in a clear and accessible way. Seeing students grow into independent scientists, capable of questioning methods and building new ones, is one of the most rewarding aspects of my work.</i>”&nbsp;</p><blockquote><h5><strong>About Bob Pirok</strong></h5><p>Bob Pirok (Den Helder, 1987) completed his MSc in analytical chemistry at the University of Amsterdam, followed by doctoral research conducted in close collaboration with industrial partners including Shell, DSM, and Heineken. After earning his PhD in 2019 with Prof. Peter Schoenmakers, Pirok was appointed tenure-track assistant professor at the Van ’t Hoff Institute for Molecular Sciences. There, he co-founded the Chemometrics and Advanced Separations Team (CAST) and was appointed associate professor in 2025.</p><p>Pirok is also a visiting researcher at Gustavus Adolphus College in the United States and Stellenbosch University in South Africa. Pirok has received the Shimadzu Young Scientist Award (2015), the Csaba Horváth Young-Scientist Award (HPLC 2017), and the Journal of Chromatography Young-Scientist Award (2018). He is a driving force within the University of Amsterdam’s analytical chemistry programs, where he teaches courses in chemometrics, statistics, and separation science and supervises many MSc and BSc students. Pirok serves on the Early Career Board of Analytical Chemistry and is active in professional networks such as the European Chemistry Thematic Network.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HIMS_Bob_Pirok_speaking_at_the_Balaton_2025_symposium_in_Siofok_Hungary_in_September_2025_106d7cffb5.jpg" alt="HIMS: Bob Pirok speaking at the Balaton 2025 symposium in Siófok, Hungary, in September 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HIMS_Bob_Pirok_speaking_at_the_Balaton_2025_symposium_in_Siofok_Hungary_in_September_2025_106d7cffb5.jpg 204w," sizes="100vw" width="857" height="655"></p></blockquote>

Bob Pirok receives LCGC Emerging Leader award

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The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

The University of Amsterdam is one of the largest comprehensive universities in Europe. With some 40,000 students, 6,000 staff, 3,000 PhD candidates, and an annual budget of more than 850 million euros, it is also one of Amsterdam’s biggest employers.

There is an inseparable link between the university and its host city. The freedom and creativity with which Amsterdam has long been associated have worked their way into the fabric of the university. This is a place where individuality, authenticity and diversity are celebrated as sources of stimulation, inspiration and innovation.

Professional and personal development, challenges and collaboration are undertaken in a versatile and multidimensional (inter)national ecosystem with leading stakeholders. Staff at the UvA make a meaningful contribution to uncovering solutions to some of the world’s most significant problems and to developing the next generation of talent.

University of Amsterdam

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

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Thermo Fisher Scientific

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SCIEX

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join us for a free e-learning opportunity! This comprehensive online workshop is designed to provide in-depth guidance on setting up quantitation studies using Thermo Scientific Proteome Discoverer Software.</strong></p><p>During the session, we will cover a range of quantitation experiments, including Label-Free Quantitation (LFQ), Stable Isotope Labeling by Amino acids in Cell culture (SILAC), and Tandem Mass Tag (TMT) labeling. These examples will help illustrate the following key points:</p><ul><li><strong>Selecting the appropriate study factor type: </strong>Learn how to choose the right factors for your study to ensure accurate and reliable results.</li><li><strong>Assigning biological and technical replicates:</strong> Understand how to properly assign replicates to accommodate both nested and non-nested experiments, ensuring robust data analysis.</li><li><strong>Optimally grouping samples: </strong>Gain insights into the best practices for grouping samples, especially when dealing with multi-batch TMT experiments, to maximize the efficiency and accuracy of your quantitation studies.</li></ul><p>This workshop is intended for both novice and intermediate users, providing valuable insights and practical knowledge to enhance your proficiency with Proteome Discoverer Software.</p><p>After the presentation, there will be ample time allocated for addressing any questions from attendees, ensuring you leave with a clear understanding of the topics covered. Don't miss this opportunity to advance your skills and knowledge in proteomics quantitation studies!</p><p><strong>Can’t join the live broadcast on July 2? Please register anyway to automatically receive an email with the link to the recording.</strong></p><blockquote><p><strong>Presenter: </strong>Michaela Scigelova (Product Support, Thermo Fisher Scientific)</p><p>Michaela provides customer support to Thermo Scientific Proteome Discoverer software users.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Quantitation study design in Proteome Discoverer software

Quantitation study design in Proteome Discoverer software

This workshop is designed to provide guidance on setting up quantitation studies using Thermo Scientific Proteome Discoverer Software.

<h4><strong>SCIEX OS software summer school - part 2</strong></h4><p><strong>Ready to take your SCIEX OS skills to the next level?</strong></p><p>Join us for part 2 of our live summer school series and continue building your confidence in SCIEX OS software. These short, 30-minute sessions are designed to fit into your day and give you actionable insights, fast.</p><ul><li>Practical, focused 30-minute sessions</li><li>Live Q&amp;A with SCIEX experts</li><li>Build confidence using SCIEX OS software</li><li>Designed for busy scientists and lab professionals</li></ul><h5><strong>Agenda:</strong></h5><ul><li>23 July, 11:00 am CET: MS tuning</li><li>6 August, 11:00 am CET:&nbsp;Compound optimization</li><li><strong>20 August, 11:00 am CET: Data acquisition (setting up your method)</strong></li><li>3 September, 11:00 am CET: Data processing (quantitation)</li></ul>

SCIEX: SCIEX OS software summer school – part 2 

SCIEX OS software summer school – part 2: Data acquisition (setting up your method)

Join us for part 2 of our live summer school series and continue building your confidence in SCIEX OS software. 

SCIEX OS software Data acquisition (setting up your method)

<h4><strong>Overview</strong></h4><ul><li>Review the definition of PFAS, importance of analysis, understanding EPA Method 1633, and simplified extraction methods.&nbsp;</li><li>Break down analytical challenges, stacked SPE extraction method, experimental setup, efficiency, and comparison of methods.&nbsp;</li><li>Walk through products and technologies, and case studies</li></ul><h4><strong>Key Learning Points</strong></h4><p>During this presentation you will review:</p><ul><li>EPA Method 1633: Gain insights into the methodology for detecting PFAS in soils and biomaterials.&nbsp;</li><li>Simplified extraction techniques: Learn about the application and benefits of simplified extraction methods, specifically using stacked SPE cartridges.&nbsp;</li><li>The contributions and technologies offered by Phenomenex to advance PFAS analysis.&nbsp;</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Anyone interested in PFAS testing or in enhancing the recovery and reproducibility of their PFAS SPE extraction methods for soils and biomaterials.</li></ul><blockquote><p><strong>Speaker: </strong>Duilio Romanello (Senior Technical Specialist)<br><br>Duilio Romanello graduated with his Bachelors of Science in Pharmaceutical Chemistry and Technology from University of Bologna. Duilio then joined Phenomenex in 2008 as an Inside Technical Sales Consultant becoming Team Leader in Italy for GC/SPE in 2010 and then for the Env/Food Team. Since 2016 he has been covering the role of Account Manager for the South of Italy working remotely and acting as GC Specialist. Since November 2023 he is Senior Technical Specialist for the Technical team at Phenomenex.</p></blockquote>

Phenomenex: Uncovering PFAS in Alternative Matrices 

Uncovering PFAS in Alternative Matrices 

Explore EPA Method 1633, stacked SPE for PFAS extraction, and Phenomenex tools to improve recovery and reproducibility in soil and biomaterial analysis.

<div><p><strong>Endocannabinoids (eCBs) are endogenous lipid messengers that interact with cannabinoid receptors CB1/CB2 and play a critical role in the central nervous system, often altered in neurological disorders. The low concentration in tissue posts a challenge to ionize and spatially analyze these compounds. Applying a laser-induced post-ionization (MALDI-2) approach improves sensitivity and limit of detection. After optimization, this method was applied to a mouse model of mild traumatic brain injury.</strong></p><p><strong>Key Learning Objectives:</strong></p><ul><li>Gain an understanding of the benefits that MALDI Imaging brings to neuropharmacology applications</li><li>Learn applications where MALDI-2 enhances sensitivity</li><li>Understand the technological benefits of MALDI-2</li></ul><h5><strong>Who should attend:</strong></h5><ul><li>Researchers in pharmacology that want to add a spatial dimension to their research</li><li>Investigators that want to expand their technological understanding of MALDI</li></ul><blockquote><p><strong>Presenter:</strong> Eduardo Sommella, Ph.D., Assoicate Professor, Department of Pharmacy, University of Salerno, Naples, Italy</p><p>Eduardo Sommella is Associate Professor in Medicinal Chemistry at the Department of Pharmacy of the University of Salerno (Italy), and coordinator of the Mass Spectrometry Platform. His work focuses on the development and application of multi-omics-mass spectrometry-based approaches for drug discovery and clinical-diagnostics fields.</p></blockquote></div>

Bruker: Visualizing the Spatial Landscape of the Brain Endocannabinoidome by MALDI-2 Imaging 

Visualizing the Spatial Landscape of the Brain Endocannabinoidome by MALDI-2 Imaging 

Explore how MALDI-2 enhances endocannabinoid imaging in brain tissue. Learn how it boosts sensitivity for neuropharmacology and brain injury research.

Visualizing the Spatial Landscape by MALDI-2 Imaging 

<p><strong>Food testing laboratories are under constant pressure to boost productivity, speed up turnaround times, and manage ever-growing sample volumes. However, conventional methods are often too time-consuming and labor-intensive, creating bottlenecks that may hinder progress.</strong></p><p>Looking for a more efficient way forward? In this latest session of Digital Classrooms, discover how Shimadzu’s innovative solutions are transforming food analysis. Learn how AOC-6000 Plus enables automated GCMS workflows for FAME analysis and automated LCMS workflows for pesticide analysis. Plus, explore Peakintelligence software—a world-first AI-assisted algorithm that simplifies chromatography peak detection and accelerates data analysis for a streamlined workflow.</p><p>Take the next step towards faster, smarter, and simpler food testing. Register now to unlock your laboratory’s full potential!</p><h5><strong>Learning Objectives:</strong></h5><ul><li>Discover Shimadzu's latest AI and automation solutions for advanced laboratory workflows</li><li>Understand how Shimadzu’s AI and automation technologies enhance laboratory throughput and efficiency compared to manual approaches</li><li>Explore practical applications of these solutions in FAME and pesticide analysis</li></ul><blockquote><p><strong>Presenter: </strong>Dr Chia Chee Geng (Senior Application Specialist, Shimadzu (Asia Pacific) Pte Ltd)</p><p>Chee Geng attained his Bachelor of Science (Chemistry) and Doctorate (Biochemistry) from the National University of Singapore (NUS). His wide exposure in the various fields of sciences enables him to communicate effectively with a larger group of scientists from different backgrounds. After graduating from NUS, he joined the industry as an Analytical Chemist, involved in projects that deal with small molecules traces analysis in the complex sample matrix, requiring hands-on experience in various kinds of mass spectrometry (Ion Trap, Q-Trap, timsTOF, Triple Quad). He is also experienced in optimizing and designing high throughput sample preparations process for LC and GC analysis via automation, in order to improve efficiency in routine workflow. Dr CCG loves learning the latest advancement in technology in the market, looking forward to sharing what he knows with the interested target audience.</p><p><strong>Presenter: </strong>Dr Yap Siew Qi (Senior Product Specialist (LCMS), Shimadzu (Asia Pacific) Pte Ltd)</p><p>Siew Qi is the Senior Product Specialist at Shimadzu Asia Pacific, specializing in LCMS. She earned her Ph.D. in Chemistry from the National University of Singapore in 2016, where her research focused on Pt (IV) complexes as prodrugs of cisplatin, utilizing various analytical techniques to assess their efficacy in cancer treatment. Since joining Shimadzu in 2017, she has held several roles, including Consumables Technical Specialist, Application Chemist and Product Specialist, where she has contributed to product development and customer engagement. Currently, as a Senior Product Specialist, she leads initiatives to enhance LCMS solutions for clients. With a solid foundation in analytical chemistry and a commitment to innovation, Siew Qi continues to drive advancements in her field.</p></blockquote>

Shimadzu: Faster, Smarter Analysis For FAMEs And Pesticides

Faster, Smarter Analysis For FAMEs And Pesticides

Discover how Shimadzu automates FAME and pesticide testing using GCMS, LCMS, and AI to boost food lab productivity and reduce turnaround times.

<p><strong>Understand Microelectrode Technology to Maximize Its Measurement Potential</strong></p><p><strong>Are you curious about how to precisely measure key parameters, such as pH and conductivity, in challenging small samples, including cell and tissue fluids, microfluidic devices, and other high-value samples? Join our upcoming webinar to discover how microelectrodes, thanks to their design, enable reliable measurements in small volumes and confined spaces where traditional electrodes are too large or intrusive.</strong></p><p>This session will provide an in-depth understanding of microelectrode technology and show you how to harness its full potential for pH and conductivity measurements.</p><p>Want to know how this webinar can benefit you? Check out the Benefit Block below to see why this is a must-attend event.</p><p>Boost Your Research Potential: Learn advanced techniques that will transform your experimental outcomes from ordinary to extraordinary.<br>Discover Emerging Innovations: Discover the latest breakthroughs and innovations in microelectrode technology that are shaping the future.<br>Connect with Fellow Experts: Engage with passionate researchers and industry experts to spark new ideas and collaborations.<br>Apply Actionable Insights: Turn insights into action by applying cutting-edge methods directly to your research projects.</p><p><strong>Event Program</strong></p><ul><li><strong>Core Principles: </strong>Understand microelectrode fundamentals and their unique advantages.</li><li><strong>Optimization Techniques: </strong>Learn strategies to boost measurement accuracy and sensitivity.</li><li><strong>Real-world Applications: </strong>Explore case studies demonstrating practical uses across fields.</li><li><strong>Troubleshooting Tips: </strong>Discover solutions to common challenges.</li><li><strong>Live Q&amp;A Session: </strong>Get your questions answered by experts in real time.</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Reena Mascarenhas</p><p>Dr. Mascarenhas is a seasoned electrochemist with over 5 years of dedicated experience at METTLER TOLEDO. Her in-depth knowledge and expertise in the field have made her a sought-after speaker for live webinars. With a strong academic foundation and a passion for electrochemical advancements, Dr. Mascarenhas is committed to sharing her insights and contributing to the growth of the scientific community.</p></blockquote>

Mettler Toledo: Microelectrodes in Action: Enhancing pH and Conductivity Measurements

Microelectrodes in Action: Enhancing pH and Conductivity Measurements

This session provide understanding of microelectrode technology and show how to harness its full potential for pH and conductivity measurements.

pH and Conductivity Measurements with microelectrodes

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join us for an insightful webinar on MS Data Processing using Thermo Scientific Chromeleon 7.3.2 software. This session is designed for anyone interested in running mass spectrometry (MS) with Chromeleon software. Whether you are a beginner or an experienced user, this webinar will provide valuable insights and practical knowledge to enhance your MS data processing skills.</strong></p><h5><strong>Topics:</strong></h5><ul><li><strong>QQQ MS Data Processing</strong>: Learn the best practices and techniques for processing triple quadrupole (QQQ) MS data using Chromeleon 7.3.2.</li><li><strong>High-Resolution MS Data Processing: </strong>Discover how to efficiently process high-resolution MS data, ensuring accuracy and reliability in your results.</li><li><strong>Chromeleon reporting for MS </strong>Users: Get tips and tricks on generating comprehensive reports tailored for MS users, utilizing the powerful reporting capabilities of Chromeleon software.</li></ul><h5><strong>Who Should Attend:&nbsp;</strong></h5><p>This webinar is open to anyone with an interest in running MS with Chromeleon. Whether you are a researcher, lab technician, or scientist, this session will equip you with the knowledge and tools to optimize your MS data processing workflows.</p><p><i>Cannot attend the broadcast on August 21? Please register anyway to automatically receive the link to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Sebastian Lopez (Lab Application Specialist | LC &amp; LCMS | Pharma &amp; Biopharma, Thermo Fisher Scientific)</p><p>Seb has been an HPLC and Mass Spectrometry Specialist at Thermo Fisher Scientific for 5 years and has over 15 years of analytical chemistry experience. He is passionate about enabling customer to achieve their analytical goals especially using technology from Thermo Fisher.</p></blockquote></div></div></div>

Thermo Fisher Scientific: How to process MS data in Chromeleon CDS software

How to process MS data in Chromeleon CDS software

Join us for an insightful webinar on MS Data Processing using Thermo Scientific Chromeleon 7.3.2 software. 

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join us for an insightful webinar where we take a deep dive into the integration capabilities of Chromeleon Chromatography Data System (CDS) with other software. This session will provide a comprehensive overview of how Chromeleon CDS interfaces with various third-party applications, enhancing your laboratory's efficiency and data management processes.&nbsp;</strong></p><p>Whether you aim to streamline your workflows or improve data interoperability, this webinar will provide you with the knowledge and tools to achieve seamless software integration.</p><h5><strong>Key takeaways:</strong></h5><ul><li>Understand the integration capabilities of Chromeleon CDS with other software</li><li>Learn how to set up and configure interfaces for optimal performance</li><li>Discover best practices for ensuring data integrity and consistency</li><li>Get answers to your specific questions during the live Q&amp;A session</li></ul><h5><strong>Who should attend:</strong></h5><ul><li>Chromeleon CDS users looking to enhance software integration</li><li>IT professionals and system administrators managing laboratory software</li><li>Laboratory managers and analysts seeking to improve data workflows</li><li>Anyone interested in learning more about Chromeleon CDS integration capabilities</li></ul><p><i>Don't miss this opportunity to enhance your understanding of Chromeleon CDS and its integration with other software. Register now to secure your spot!</i><br>&nbsp;</p><blockquote><p><strong>Presenter: </strong>Kimy Young (Senior Manager, Software Product Specialists, Thermo Fisher Scientific)</p><p>Kimy Young is the Senior Manager of software product specialists at Thermo Fisher Scientific. She has been with Thermo Fisher since November 2015. Her background includes administration of Chromeleon CDS, laboratory information management systems (LIMS), Quality Assurance (QA), and IT projects.</p><p><strong>Presenter: </strong>Juan Carmona (Chromeleon CDS Specialist, Thermo Fisher Scientific)</p><p>Juan Carmona is a Chromeleon Specialist at Thermo Fisher Scientific based out of Pflugerville, TX. He has been with Thermo Fisher Scientific for over 15 years. At Thermo Fisher Scientific, he is currently focusing on expanding the customer base using Chromeleon CDS for small networks and enterprise deployments. Prior to joining this group, he was part of the GC/GCMS Center of Excellence team providing support for the product line.</p><p><strong>Presenter: </strong>Monica Driscoll (Regional Marketing Specialist, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Chromeleon CDS webinar series

Chromeleon CDS connections – Exploring options for interfaces

Discover Chromeleon CDS integration tips and best practices to improve lab data workflows and software interoperability. Live Q&A with Thermo Fisher experts.

Chromeleon CDS – Exploring options for interfaces

<p><strong>When analyzers underperform, the issue is rarely the instrument itself, it’s the sample. In fact, studies show that up to 80% of analyzer problems originate in the sampling system. If the sample isn’t representative, even the most advanced analyzer can’t deliver meaningful data.</strong></p><p>This webinar takes a critical look at the role of sampling system design in achieving accurate, timely measurements. You’ll gain insights into how to minimize lag time, avoid dead volume and maintain steady flow, ensuring your analyzer sees the process as it truly is. We’ll also cover practical piping considerations, filtration strategies and loop configurations that preserve sample integrity and improve system responsiveness.</p><p>Bring your curiosity, challenges and questions, you’ll have the chance to ask them directly to our experts during a live Q&amp;A. This session will feature a live discussion between two industry experts as they walk through real-world examples, highlight common design pitfalls, and unpack the planning decisions that lead to more reliable results.</p><h5><strong>This webinar is ideal for:</strong></h5><ul><li><strong>Production and Operations Leaders</strong> – including Production Managers, Plant Managers, and Operational Managers</li><li><strong>Technical and Quality Experts</strong> – such as Process Engineers, Quality Control Specialists, and Automation &amp; Control Engineers</li><li><strong>Strategic Decision-Makers </strong>– such as Project Leads and Technical Stakeholders</li></ul><h5><strong>Key learning points</strong></h5><ul><li><strong>Implementation Strategy:</strong> Learn how to assess feasibility, avoid common pitfalls, and implement robust sampling.</li><li><strong>System Design &amp; Integration:</strong> Explore how to design and build a robust sample flow path.</li><li><strong>Smart Control:</strong> Understand how to program QC checks and sequencing logic to boost confidence and reduce errors.</li></ul><blockquote><p><strong>Presenter: </strong>Brad Herbert (Sr. Process Engineer, Jacobs)</p><p>Brad Herbert is a Sr. Process Engineer with Jacobs. Brad’s areas of focus include ultrapure water, wastewater, chemicals, mentoring, and staff development. Over the past 30 years, Brad has worked as a global facilities engineer, site facilities engineer, facilities manager, design consultant, project manager, and product engineer in the semiconductor and water treatment industries. He has led engineering efforts, managed projects, and supported operations throughout The Americas, Europe, and Asia. His work history includes onsemi, LSI Logic, AMD, IDC (CH2M), DeNora Water Technologies, Monsanto, and Sigma-Aldrich. Brad is a licensed Professional Engineer and has a B.S. Degree in Chemical Engineering from the University of Missouri.</p><p><strong>Presenter:&nbsp;</strong>Brett Lane (Process Wet Chemistry Field Applications Specialist, Metrohm USA)</p><p>Brett joined Metrohm USA in 2021 after working as a senior chemist in an industrial/pharmaceutical quality control laboratory. He has a background in auto-titration, chromatography, mass spectrometry and spectroscopy. His current focus is on applications development for advanced online wet chemistry analysis including titration and ion chromatography systems. Brett graduated from the University of Guelph in 2016 with a BSc. in Chemical Physics, spending time at several R&amp;D internships.</p></blockquote>

Metrohm: What Your Analyzer Isn’t Telling You: The Role of Sampling Design

What Your Analyzer Isn’t Telling You: The Role of Sampling Design

Learn why sampling—not the analyzer—is often the weak link. Improve accuracy with better system design. Join industry experts for insights and real-world tips.

What Your Analyzer Misses: Sampling Design

<h4><strong>Nitrosamine Analysis Made Simple: Achieve Compliance with Shimadzu Mass Spectrometry</strong></h4><p>Nitrosamine impurities are a growing concern in the pharmaceutical industry due to their toxicity and strict regulatory limits. This webinar will showcase how Shimadzu’s high-sensitivity LC-MS and GC-MS platforms help streamline nitrosamine detection in complex matrices, reduce method development time, and ensure compliance with FDA, EMA, and ICH M7 guidelines. Through expert insights and real-world examples, you’ll learn how to implement efficient workflows for your QA/QC and R&amp;D labs.</p><h5><strong>Learning Objectives:</strong></h5><ul><li>An overview of current regulatory requirements for nitrosamine testing (USP and FDA)</li><li>Challenges in detecting nitrosamines in complex pharmaceutical matrices.</li><li>How Shimadzu’s LC-MS and GC-MS systems deliver high sensitivity and reliable results.</li><li>Streamlined workflows techniques to reduce analysis time.</li><li>Real-world case studies demonstrating successful nitrosamine analysis in QA/QC and R&amp;D.</li></ul><h5><strong>Who should attend:</strong></h5><ul><li>Pharma QA/QC</li><li>Pharma R&amp;D</li><li>Regulatory Affair in need to comply with nitrosamines analysis</li></ul><blockquote><p><strong>Presenter:</strong> Kevin Wons (Market Manager - Pharma/BioPharma, Shimadzu Scientific Instruments)</p><p>Kevin is the Market Manager for Pharma/BioPharma at Shimadzu Scientific Instruments. Prior to that, Kevin worked in Analytical R&amp;D in biopharma for over 6 years, with experience in characterization for biologics. He also has over 3 years of experience in the academia field doing neuroscience research.</p></blockquote>

Shimadzu: Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Shimadzu webinar: Simplify nitrosamine testing with LC-MS/GC-MS. Achieve regulatory compliance and streamline workflows for pharma QA/QC and R&D labs.

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