Ask any analytical chemist which hyphenated technique has become indispensable over the past decade, and the answer will almost certainly be the same: tandem chromatography–mass spectrometry. Whether it is <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis">LC–MS/MS</a> quantifying a novel biologic’s metabolic fate, or <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-gc-ms/ms-analysis">GC–MS/MS</a> chasing per- and polyfluoroalkyl substances (PFAS) down to sub-part-per-trillion levels in municipal water, the combination of chromatographic separation with the specificity of tandem mass detection has become the analytical workhorse of choice across virtually every regulated sector.Below we examine the key forces propelling this expansion, from biopharma pipeline dynamics and PFAS regulatory mandates to AI-driven automation and reshoring of pharmaceutical manufacturing—and explore what each trend means for laboratories managing sample preparation and analytical workflows.<h3>Biopharma: The Engine Room of LC–MS/MS Demand</h3><h4>GLP-1 Agonists and the Metabolomics Gold Rush</h4>The explosive commercial and scientific interest in GLP-1 receptor agonists—<a target="_blank" rel="noopener noreferrer" href="https://www.sepscience.com/advancing-glp-1-peptide-analysis-chromatography-challenges-and-innovations-12163">semaglutide and related peptide therapeutics </a>for diabetes and obesity—has dramatically expanded the analytical demands placed on tandem MS platforms. Discovery programs require precise quantification of peptide drug candidates and endogenous biomarkers across complex biological matrices. These workflows rely on high-sensitivity LC–MS/MS for pharmacokinetic profiling, receptor occupancy studies, and metabolomics characterization. Metabolomics is, in fact, projected to be the fastest-growing application segment in mass spectrometry, driven in part by its growing role in cancer screening, biomarker discovery, and metabolic disease research.I have been spending more time learning about GLP-1s because this is the hot topic that people want to discuss on the Concentrating on <a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL?si=n9GLz9zjSCOrVfXPxFPhng&amp;nd=1&amp;dlsi=52868e027aad4d22">Chromatography podcast</a>. With that said, I was astounded looking at CNBC.com during breakfast this morning to see that <a target="_blank" rel="noopener noreferrer" href="https://www.cnbc.com/2026/03/21/glp-1-diets-restaurants-protein-fiber-weight-loss-drugs.html">one in eight Americans are currently taking one of these drugs such as Ozempic</a>.<h4>Antibody–Drug Conjugates and Gene Therapy: Complexity at Every Step</h4>The ascent of antibody–drug conjugates (ADCs) and gene therapies has introduced a new level of analytical complexity. ADCs blend the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads—and characterizing the linker chemistry, drug-to-antibody ratio (DAR), and conjugate stability demands high-resolution LC–MS/MS at every stage from discovery through QC release testing. Gene therapy vectors require equally rigorous characterization of impurities, aggregates, and empty/full capsid ratios.This translates into a direct need for low-evaporation, high-recovery concentration methods that preserve labile protein structures and maintain sample integrity prior to LC–MS/MS injection. <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">Nitrogen evaporation workflows</a> that minimize oxidative stress and maintain sample temperature are increasingly critical in these pipelines.<h4>Precision Medicine and Multi-Omics Integration</h4>The shift toward precision medicine has accelerated adoption of high-throughput, multi-analyte MS platforms. Proteomics, metabolomics, and lipidomics workflows are converging on a single analytical platform—tandem MS—and generating datasets of a scale and complexity that were unimaginable ten years ago.Make no mistake: the triple quadrupole serves an irreplaceable role in quantitative targeted analysis. At the same time, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3">Orbitrap </a>and Q–TOF hybrid platforms are growing rapidly as researchers demand full-scan accurate mass for untargeted discovery.<h3>Environmental Mandates: PFAS Testing Drives Adoption</h3>Environmental testing is something that every person, chemist or not, can understand the importance of. Mounting mandates from the U.S. Environmental Protection Agency and European regulators regarding PFAS—the “forever chemicals” whose extraordinary environmental persistence is matched only by the analytical challenge of detecting them at trace levels—have created immediate, compliance-driven investment in LC–MS/MS infrastructure.<h4>The Regulatory Framework Chemists Need to Know</h4>The EPA has codified a suite of LC–MS/MS-based methods as the analytical standard for PFAS in water and solid matrices:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe">EPA Method 533</a>: Weak anion exchange SPE combined with LC–MS/MS; covers 25 PFAS including short-chain compounds in drinking water.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination">EPA Method 537.1</a>: Reversed-phase SPE followed by LC–MS/MS; covers 18 PFAS including the GenX compound, with method detection limits in the low ng/L range.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/en/solutions/environmental/water-testing/pfas-in-water/us-epa-method-8327?srsltid=AfmBOooCY1pcavj7B1PH-75d3HO4BGDglNlhmyTyrpDY3zvUksMO1dlg">EPA Method 8327</a>: LC–MS/MS for selected PFAS in prepared extracts of aqueous and solid matrices.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633">EPA Draft Method 1633</a>: The emerging benchmark for PFAS in non-aqueous matrices—aqueous, solid, biosolids, and tissue—quantifying up to 40 PFAS.</li></ul>All of these methods designate LC–MS/MS, specifically LC coupled to triple quadrupole or tandem-in-time platforms operating in negative electrospray ionization mode with multiple reaction monitoring (MRM), as the required or recommended analytical technique. PFAS analysis is, at its core, an LC–MS/MS problem.<h4>The Sample Preparation Bottleneck</h4>Chemists who have worked with PFAS methods understand the particular demands they place on sample preparation. The ubiquity of<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/tackling-pfas-contamination-practical-insights-from-epa-537.1-method-development"> PFAS in laboratory materials</a>—PTFE tubing, some SPE sorbents, standard bench supplies—means that blank contamination control is as analytically demanding as the detection itself. EPA 537.1 requires that sample volumes of approximately 250 mL be extracted and reconstituted in as little as 1 mL, creating a 250:1 concentration factor that can expose even trace contamination in the sample processing chain. The installation of a delay column between the LC pump and autosampler to prevent instrument background interference is now standard practice.This is precisely where robust, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5385">inert nitrogen evaporation </a>systems earn their keep. PFAS workflows that use nitrogen-assisted evaporation to concentrate extracts prior to reconstitution benefit from materials that avoid PTFE and other fluoropolymers that can leach PFAS background—a consideration Organomation addresses in its concentration system designs.The analytical community is also moving beyond targeted PFAS analysis. High-resolution accurate mass (HRAM) spectrometry via Orbitrap technology, paired with non-targeted screening workflows, is gaining traction for the identification of the more than 5,000 currently catalogued PFAS compounds and the novel structures that continue to emerge. LC–MS/MS remains the quantitative gold standard; HRAM provides the discovery layer.<h3>Technological Trends Reshaping the LC–MS/MS Workflow</h3><h4>Artificial Intelligence and Automated Data Interpretation</h4>The datasets generated by modern tandem MS platforms—particularly in omics applications—are too large and too complex for conventional manual review. AI-driven spectral deconvolution, automated peak integration, and AI-assisted hypothesis generation are now embedded in the software suites accompanying leading instruments. <a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/about/newsroom/presrel/2022/17feb-gp22004.html?srsltid=AfmBOop3warRIaEojXM2YyMML6RXfMIDzE-Wm0h-SiKkkocBeeET2m7u">Agilent’s acquisition of Virtual Control’s ACIES </a>software specifically to automate LC–MS and GC–MS data analysis is emblematic of this direction.For laboratory managers, AI integration means smaller specialized teams can operate high-throughput multi-analyte workflows—but it also means that the front-end sample preparation must be even more reproducible, since algorithmic interpretation amplifies inconsistencies introduced upstream.<h4>Online SPE Coupling and “Chromatography Without Walls”</h4>A significant trend is the integration of solid-phase extraction directly into the HPLC flow path—so-called online SPE–HPLC coupling. Systems that combine extraction and chromatographic separation in a single analytical instrument reduce manual transfer steps, minimize the risk of sample loss or contamination, and dramatically increase throughput. For analytes at very low concentrations, online SPE provides the on-column concentration capability that traditional offline preparation achieves with manual evaporation steps.That said, offline sample preparation—including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">nitrogen-assisted evaporation</a> under controlled conditions, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2407">liquid–liquid extraction</a>, and protein precipitation—retains significant advantages in flexibility, matrix handling, and the ability to process sample volumes that exceed online system capacity. The two approaches are increasingly complementary rather than competitive in well-designed analytical laboratories.<h4>High-Purity Solvents and Reference Materials</h4>As detection limits push further into the femtogram range and regulatory methods demand demonstrable blank performance, the quality of analytical consumables—mobile phase solvents, derivatization reagents, reference standards—has moved from background consideration to front-of-mind. Method validation in regulated environments now routinely requires vendor certification of solvent purity at a level that directly interfaces with instrument performance.<h3>The Ever-Present Need for Sample Evaporation</h3>As LC–MS/MS methods push detection limits lower, the analytical burden shifts increasingly upstream. The quality of the concentration, cleanup, and reconstitution steps preceding injection determines whether the instrument’s theoretical sensitivity is achievable in practice.Several specific developments are particularly relevant:<ul><li>ADC and gene therapy characterization workflows require gentle, low-temperature evaporation that preserves protein structure and prevents aggregation prior to LC–MS/MS. Nitrogen evaporation under controlled conditions is the preferred approach.</li><li>PFAS trace analysis demands evaporation systems constructed from PFAS-inert materials, with rigorous attention to avoiding fluoropolymer surfaces throughout the sample path.</li><li>High-throughput pharmaceutical QC driven by reshoring demands parallel processing capability—multi-position evaporators that maintain consistent flow and temperature across all positions simultaneously.</li><li>Multi-omics and metabolomics workflows generate large sample batches that benefit from automated, walk-away evaporation with programmable endpoints to ensure reproducible final volumes across a cohort.</li></ul>Tandem chromatography–mass spectrometry is not merely growing; it is becoming structurally embedded in the analytical workflows of every major regulated industry. The convergence of biopharma complexity, PFAS regulatory mandates, AI-enabled data analysis, and pharmaceutical reshoring is creating a multi-year demand cycle that will require laboratories to invest not only in instruments, but in the entire sample preparation ecosystem that makes those instruments perform.For analytical chemists, the practical takeaway is this: as mass spectrometry sensitivity continues to advance, the sample preparation step becomes the binding constraint on method performance. Whether you are developing a new PFAS method to meet EPA 1633, characterizing an ADC’s drug-to-antibody ratio, or running a 500-sample metabolomics cohort overnight, the reliability and cleanliness of your concentration and cleanup workflow determines the quality of every data point that follows.&nbsp;

The Continued Rise of Tandem Chromatography–Mass Spectrometry

<h3>A Practical Guide to Getting the Most from Syringe Filters: Tips, Tricks, and Common Pitfalls</h3>Syringe filters play a crucial role in chromatography and many other laboratory applications by removing particulate matter before analysis. Proper sample filtration helps protect analytical instruments, extends column lifetime, and improves data quality. However, selecting an unsuitable filter—or using one incorrectly—can introduce contamination, reduce filtration efficiency, or even compromise analytical results. The following recommendations will help you avoid common mistakes and ensure reliable filtration every time.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp" alt="KNAUER: Avoiding Common Syringe Filter Mistakes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp 133w," sizes="100vw" width="1276" height="1496"><h4>1. Improper Filter Handling</h4>Using excessive force during filtration or attempting to reuse disposable syringe filters can damage the membrane and increase the risk of sample contamination.<ul><li>Solution: Apply slow, even pressure throughout the filtration process and always dispose of single-use filters after one use. If the flow rate decreases noticeably, replace the filter instead of applying additional force.</li></ul><h4>2. Selecting an Inappropriate Pore Size</h4>Using the wrong pore size may either fail to remove unwanted particles or cause the membrane to clog prematurely, reducing filtration efficiency.<ul><li>Solution: A 0.45 µm membrane is generally suitable for routine particulate removal, while a 0.22 µm membrane is recommended for finer filtration and bacterial removal. Samples with higher viscosity may require a pre-filter to prevent rapid clogging. It is also important to consider the intended analytical technique. For example, 0.22 µm filters are typically preferred for UHPLC and LC-MS applications, whereas 0.45 µm filters are often sufficient for conventional HPLC analyses.</li></ul><h4>3. Choosing the Wrong Membrane Material</h4>Different membrane materials exhibit different chemical resistance. Using an incompatible membrane may lead to degradation of the filter, sample contamination, or complete filtration failure.<ul><li>Solution: Always verify solvent compatibility before filtration. PTFE membranes are an excellent choice for organic solvents, while PES and nylon membranes are better suited to aqueous samples. If compatibility is uncertain, perform a small-scale trial before filtering valuable samples.</li><li>Pro Tip: For additional guidance, see our blog article "How to Choose the Right Membrane for your Syringe Filter", which provides a detailed comparison of membrane materials and their recommended applications.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg" alt="KNAUER Sepapure® Syringe Filters are available with multiple membrane materials, each identified by a dedicated color code for quick and reliable selection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg 245w," sizes="100vw" width="1580" height="902"><h4>4. Ignoring Filter Capacity</h4>Using a filter with insufficient capacity can result in rapid membrane blockage, increasing filtration time and reducing laboratory productivity.<ul><li>Solution: When filtering larger sample volumes, choose high-capacity syringe filters or introduce a pre-filtration step. Never force liquid through a clogged membrane, as doing so may damage the filter and negatively affect sample quality.</li></ul><h4>5. Overlooking Sample Adsorption</h4>Certain membrane materials may adsorb analytes of interest, leading to lower recoveries and potentially affecting quantitative results.<ul><li>Solution: For protein samples or other adsorption-sensitive analytes, select membranes with low binding characteristics, such as nylon or glass fiber, whenever appropriate. Performing a small recovery test before routine analysis can help identify potential analyte losses.</li></ul><h4>6. Failing to Optimize Filtration Performance</h4>Slow filtration is more than just an inconvenience—it often indicates that the filtration conditions are not optimal.<ul><li>Solution: If filtration becomes unusually slow, investigate possible causes such as membrane clogging, excessive sample viscosity, or an unnecessarily small pore size. Depending on the sample, dilution or sequential filtration using progressively finer filters may significantly improve performance.</li></ul><h4>Final Thoughts</h4>Selecting the appropriate syringe filter is a straightforward process, but overlooking small details can have a significant impact on analytical performance. Choosing the correct membrane material, pore size, and filtration strategy helps improve laboratory efficiency, protects chromatography systems and columns, and contributes to accurate, reproducible analytical results.With the right syringe filter and proper filtration technique, you can minimize sample preparation problems and maximize confidence in every analysis.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg" alt="KNAUER: Sepapure® Syringe Filter Selection" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg 245w," sizes="100vw" width="1160" height="627">Happy filtering!

Avoiding Common Syringe Filter Mistakes

News from LabRulezLCMS Library - Week 27, 2026

Article

Product

Application

Academy

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Separation Science

Agilent Technologies

Thermo Fisher Scientific

Waters Corporation

This time we will give an overview and demonstration of the SELECT SERIES MRT for small molecule metabolite workflows such as metabolomics and drug metabolite identification.
During this demo, Adam will show how the MRT’s mass resolution of 200,000 and sub ppm mass accuracy for MS and MS/MS data can be maintained at the fast acquisition rates needed for integration with UPLC and how this aids metabolite identification. In addition, you will discover new acquisition modes which further enhance performance.
The session will conclude with a live Q&amp;A where Adam and other members of the team will be on hand to answer all of your questions. 
Why Should You Attend?
<ul>
<li>Discover how the characteristics of the MRT combine with UPLC to aid metabolic profiling workflows.</li>
<li>Learn how the different acquisition modes work to enhance performance.</li>
<li>Understand how MRT data is processed for various small molecule workflows.</li>
</ul>
<blockquote>
Presenter: Adam King (Senior Scientist, MS Discovery Program, Waters Corporation)
</blockquote>
<blockquote>
Adam joined Waters in 2015 working for the phenotyping group based at Imperial College London, supporting the National Phenome centre with technical support and training. In 2018, Adam relocated to Wilmslow as part of the biomedical research team within SciOps focusing on metabolomic analysis using Waters high resolution MS solutions and Ion mobility.
</blockquote>
<blockquote>
Prior to joining Waters, Adam obtained his BSc in Biochemistry from Kingston University, London, and worked in the pharmaceutical industry leading a team of scientist analyzing NCEs by LC-MS in the company&#39;s bioanalytical team.
</blockquote>
<blockquote>
Currently Adam is a Senior Scientist in the MS Discovery program group continuing to focus on high resolution MS and IM for metabolomics. Additionally, Adam is in the final stages of completing a part-time PhD in Metabolomics at Murdoch University in Perth, Australia.
</blockquote>

Unquestioned Confidence in Metabolic Profiling

How the MRT’s mass resolution of 200,000 and sub ppm mass accuracy for MS and MS/MS data can be maintained at the fast acquisition rates.

In our third SELECT SERIES MRT in Action deminar join us to see how the exceptional resolving power of the MRT can help you make faster and better-informed decisions on Biopharmaceutical workflows.
During the demo, Dale will show how subtle modifications to primary structure such as differences to the isotope distributions of native and deamidated peptides can be unveiled with the MRT and how the high resolution of the MRT has benefits for protein analysis in that fully-resolved isotope distributions can be obtained, aiding in deconvolution to monoisotopic mass.
The session will conclude with a live Q&amp;A where Dale and other members of the team will be on hand to answer all of your questions. 
Why Should You Attend?
<ul>
<li>Discover how the characteristics of the MRT aid biologics characterization workflows.</li>
<li>Learn how the different acquisition modes work to enhance performance.</li>
<li>Understand how MRT data is processed for various biopharmaceutical workflows.</li>
</ul>
<blockquote>
Presenter: Dale Cooper-Shepherd (Principal Scientist, Advanced Mass Spectrometry, Waters Corporation)
</blockquote>
<blockquote>
Dale is a Senior Scientist in the Discovery MS group at Waters, Wilmslow, UK. He undertook PhD studies at the University of Leeds and conducted postdoctoral research at the University of Oxford, UK. Throughout his training Dale specialized in applying ion mobility MS in the field of structural biology.
</blockquote>
<blockquote>
Dale joined Waters in 2015 and since 2019 has been working as an applications scientist on the SELECT SERIES of instruments.
</blockquote>

Elevated Biologics Characterization

How subtle modifications to primary structure such as differences to the isotope distributions of native and deamidated peptides can be unveiled with the MRT.

It’s an exciting time to be a proteomics researcher without a doubt. For years the biggest challenge has been the sheer volume of samples to be analysed. The recent launch of the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer has promised to be a true game-changer.
For the first time ever, an instrument is available which offers the capability to do high throughput studies of large cohort samples without compromising performance. Join us for this review of presentations from the recent BSPR-EuPA conference showcasing the latest innovations.
Learning points:
<ul>
<li>Latest advances in high throughput proteomics
</li>
<li>Latest advances in large cohort analysis
</li>
<li>Revolutionary instrumentation for deeper proteome coverage
</li>
</ul>
Who should attend:
<ul>
<li>Director, Managers and Researchers in Proteomics
</li>
<li>Director, Managers and Researchers in Cancer Research facilities
</li>
<li>Current users of Orbitrap technology &amp; QTOF MS analysing plasma proteins
</li>
</ul>
<blockquote>
Presenter: Prof Michael MacCoss (Director of MacCoss Lab, University of Washington, Department of Genome Sciences)
</blockquote>
<blockquote>
Michael J MacCoss was born in western Canada to British parents, before relocating to Freehold, New Jersey where he grew up. Mike attended the University of Vermont as an undergrad, receiving a Bachelor of Arts in Chemistry. However, his passion for research only truly came to be after an internship in Dr. Patrick Griffin’s protein mass spectrometry lab at Merck Research Laboratories, and he began pursuing a path in biotechnology.
</blockquote>
<blockquote>
Eventually, Mike obtained a Ph.D. with Professor Dwight Matthews, also at the University of Vermont, and followed that with a post-doc at Scripps Research Institute with Professor John R. Yates III. In 2004 he started the MacCoss lab at the University of Washington with a major emphasis on developing robust and quantitative protein assays.
</blockquote>
<blockquote>
Over the last 14 years, Mike and his team have become leaders in the field of quantitative proteomics. The focus of his lab is the development of methods and software for generating and disseminating quantitative protein assays.
</blockquote>
<blockquote>
Presenter: Dr. Jo Kirkpatrick (Senior Product Specilaist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Jo has a degree in Chemistry from the University of York and a PhD in analytical chemistry from the University of Reading. Following a post-doc in mass spectrometry in the Chemistry department at Oxford, and working as an application scientist at Waters, she has worked in and ran Proteomics Core Facilities in the UK and Germany, including the EMBL in Heidelberg, the Leibniz Institute on Aging in Jena, The Francis Crick Institute in London and CRUK Cambridge.
</blockquote>
<blockquote>
After many years as an experienced Thermo customer, Jo joined the company earlier this year as a Technical Sales Specialist, supporting the whole of the UK/Ireland, Benelux and Nordic regions, in all things proteomics.
</blockquote>
<blockquote>
When she&#39;s not talking about proteomics and mass spectrometry, Jo enjoys ceroc dancing, tennis, scuba diving, travelling, and spending time with her cats, who like to join in on Teams meetings whenever she works from home.
</blockquote>
<blockquote>
Presenter: Dr. Paul Humphrey (EMEA Senior Regional Marketing Manager, LSMS, Omics and ClinTox, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Paul has a degree in Analytical Chemistry and a PhD in Secondary Ion Mass Spectrometry from the University of Manchester.
</blockquote>
<blockquote>
He previously managed a contract analysis laboratory for several years before moving into a career in the scientific instrument manufacturing industry.
</blockquote>
<blockquote>
Initially an application chemist and product manager he moved into international scientific marketing when he joined Thermo Fisher Scientific in 1997. Since then he has worked in a variety of roles within factory, field marketing and sales office organisations. He has travelled and presented extensively and has been responsible for business in EMEA, North America and Asia/Pacific regions.
</blockquote>
<blockquote>
He lives in the UK and when not working he enjoys travelling, photography, cookery and scuba-diving.
</blockquote>
<blockquote>
Presenter: Robert van Ling (Product Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Robert started his low flow chromatography career as an intern from the Technical School in Amsterdam, The Netherlands, at LC Packings in the mid-90s.
</blockquote>
<blockquote>
Since those early years, Robert has been part of the teams introducing and supporting a wide range of our nano- and capLC products, such as the UltiMate and UltiMate 3000 nanoLC systems, PepMap and EASY-Spray columns. In recent years, he has introduced our new µPAC Neo HPLC column line, an innovative and unique approach to significantly improve the performance and reliability in low flow proteomic separations.
</blockquote>
<blockquote>
Robert still lives in the wider Amsterdam region, and when not talking low flow separations very much enjoys reading fantasy, jigsaw puzzling and listening to prog and hard rock.
 
</blockquote>

Thermo Scientific: Proteomics unleashed: exclusive insights and updates from BSPR-EuPA

Proteomics unleashed: exclusive insights and updates from BSPR-EuPA

Review of presentations from the recent BSPR-EuPA conference showcasing the latest innovations.

Exclusive insights and updates from BSPR-EuPA

In this work, we present novel, automated, and integrated software to support these workflows using LC HRAM MS instruments.
Purity and sequencing data are presented for a multitude of oligos including antisense, aptamer, and long synthetic samples.
<blockquote>
Presenter: Shashank Jain, PhD (Mass Spec product specialist, New England, Agilent Technologies, Inc.)
</blockquote>

Agilent Technologies: Relieve the Pressure of Oligo Characterization by Implementing Automated Workflows

Relieve the Pressure of Oligo Characterization by Implementing Automated Workflows

Novel, automated, and integrated software to support these workflows using LC HRAM MS instruments.

Oligo Characterization by Implementing Automated Workflows

The identification of extractables, leachables and chemical migration is a challenge for manufacturers and suppliers of packaging materials, medical devices and food contact materials. E&amp;L analytics is already complex, but it is compounded by legislative and regulatory efforts to recycle plastics. Analytical methods need to screen for not only the known components but also identify degradants and other unexpected compounds. Manufacturers, producers and retailers face the challenge of keeping up with evolving requirements and developing and adapting strategies to reduce plastic waste.
Thus, ways are being explored to incorporate more recycled plastics into products and packaging while maintaining excellent safety, quality and performance characteristics. As they innovate and combine new materials, companies must demonstrate safety and confirm compliance before bringing their products to market. This again increases the demand and importance of highly effective analytics.
Register now for this virtual event and share knowledge and challenges with peers and E&amp;L experts.
Who Should Attend?
The webinars are focused on the needs of scientists working in the area of Extractables &amp; Leachables and Food Contact Materials. During these webinars, attendees will learn:
<ul>
<li>Upcoming and new regulations in the field of food, pharma, biopharma and medical devices
</li>
<li>Targeted and non-targeted screening workflows by using Waters_Connect
</li>
<li>Characterization and structural elucidation of unknowns
</li>
<li>Choice of chromatographic techniques, extraction methods and analytical standards &amp; reagents
</li>
</ul>
<h3>EPISODE 3 - Virtual European Workshop on Extractables &amp; Leachables for Medical Devices</h3>
Agenda:
<h4>The role of chemical characterization in the evaluation of the biological safety of medical devices</h4>
<ul>
<li>Dr. Séverine Colas, Chief Scientific Officer, TentaConsult Pharma &amp; Med GmbH, Germany</li>
</ul>
<h4>Chemical Characterisation of Dressings: Extraction and Analytical Challenges</h4>
<ul>
<li>Pauline Kisseleff, Analytical Expert, URGO Recherche Innovation et Développement, France</li>
</ul>
<h4>Leachables from Pharma and Medical device materials, a non-target challenging analysis</h4>
<ul>
<li>Prof. Cristina Nerin, University of Zaragossa, Spain</li>
</ul>
<blockquote>
Presenter: Dr. Séverine Colas (Chief Scientific Officer, TentaConsult Pharma &amp; Med GmbH)
</blockquote>
<blockquote>
Séverine Colas is a PhD and a toxicologist (ERT) with more than fifteen years of experience in regulatory toxicology. She has always worked in services for the safety and regulatory compliance of products, initially with pharmaceuticals, then with chemicals and for more than 10 years now with medical devices. She has joined the TentaConsult team to provide to the client her strong expertise on biological evaluation of medical devices (MDR, ISO 10993-1 and related guidelines) and support them to establish the best strategy for the compliance of their medical device throughout their life cycle. If testing is needed to complete the evaluation, she also provides the client with her experience in conducting biocompatibility studies to find the suitable laboratory and to establish the more pertinent study design. As Chief Scientific Officer and Sales Director in TentaConsult, she is the preferred contact of the client to provide the best offer for the need.
</blockquote>
<blockquote>
Presenter: Pauline Kisseleff (Analytical Expert, URGO Recherche Innovation et Développement)
</blockquote>
<blockquote>
Pauline Kisseleff has a Master degree in analytical chemistry and received her PhD on container-content interactions applied to cosmetic products in 2020. She is currently in charge of extractables and leachables studies at URGO Research, Innovation and Development, where she works on several medical devices such as technological dressings
</blockquote>
<blockquote>
Presenter: Cristina Nerin (Professor, Department of Analytical Chemistry, University of Zaragoza)
</blockquote>
<blockquote>
Full Professor at the University of Zaragoza (Spain), PhD in Analytical Chemistry, Master in Science (Analytical Chemistry) and Degree in Chemistry at the University of Zaragoza (Spain). Director of the Research Group GUIA at the University of Zaragoza and Director of the Master in Environmental Engineering at the University of Zaragoza from 1990 to 2012. Author of more than 395 Scientific Publications included in the Citation Index, Director of 38 PhD Thesis (5 more are in process). Principal Investigator of more than 240 Research Projects in both Competitive calls and also R&amp;D&amp;I with Industry Inventor in six International Patents dealing with active packaging and in one International Patent on Intelligent Packaging. All of them are in exploitation (market). Six Research Awards received. Participant in more than 140 International Conferences and Professor of several International Courses n Europe, Asia and South-America.
</blockquote>

Waters Corporation: Virtual European Workshop on Extractables & Leachables for Medical Devices

Virtual European Workshop on Extractables & Leachables for Medical Devices

Register now for this virtual event and share knowledge and challenges with peers and E&L experts.

Virtual European Workshop on Extractables & Leachables

The advancement of CRISPR-based gene editing tools into biotherapeutics offers the potential for cures to genetic disorders and for new treatment paradigms for even common diseases.
Arguably, the most important component of a CRISPR-based medicine is the guide RNA that dictates the on-target editing site as well as potential undesired off-target edits.
To ensure the spacer region is of high fidelity, top-down mass spectrometry was implemented to provide direct and quantitative assessments of highly modified gRNA. In addition to sequencing the spacer region and pinpointing modifications, top-down mass spectra were utilized to quantify single-base spacer substitution impurities down to &lt;1% and to decipher highly dissimilar spacers. 
To accomplish these results in an automated fashion, we devised custom software capable of sequencing and quantifying impurities in gRNA spacers. Notably, we developed automated tools that enabled the quantification of single-base substitutions, including advanced isotopic pattern matching for C &gt; U and U &gt; C substitutions, and created a de novo sequencing strategy to facilitate the identification and quantification of gRNA impurities with highly dissimilar spacer regions.
By attending this presentation you will:
<ul>
<li>Gain an understanding of gRNA spacer characterization by MS/MS.
</li>
<li>Learn about gRNA impurity analysis by MS/MS.
</li>
</ul>
<blockquote>
Presenter: Luis A. Macias, PhD (Mass Spectrometry Scientist, Verve Therapeutics)
</blockquote>
<blockquote>
Luis joined Verve in 2022 as a mass spectrometry scientist focusing on support and development of gRNA characterization methods. Prior to joining Verve, Luis was a graduate student in the Brodbelt lab at the University of Texas, where he developed mass spectrometry-based methods to examine structural features of proteins and lipids.
</blockquote>

Separation Science: Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry

Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry

Learn about gRNA impurity analysis by MS/MS.

Spacer Fidelity Assessments of Guide RNA

Ion Mobility (IM) advancements in Software, Data Bases, AI and Machine learning are quickly improving capabilities to make unknown identifications, separate and ID isomers, as well as improve workflows associated with metabolomics, lipidomics, PFAS, and qual-quant screening.
In addition, IM measurements are significantly improved with HRdm High Resolution Demultiplexing. This is the first commercial IM instrument to enable the simultaneous combination of high drift resolution, while at the same time achieving all four of the following measurement capabilities: broad mass range in a single injection, multiplexing to increase sensitivity, compatibility with fast chromatographic acquisition rates , and highest precision in CCS measurements. For more accurate CCS predictions, the better precision in the CCS training set improves AI machine learning SW. This can significantly reduce the number of potential candidate structures to select from when making unknown identifications.
<blockquote>
Presenter: Xueyun Zheng, PhD (Integrative Omics Group, Pacific Northwest National Laboratory)
</blockquote>

Agilent Technologies: LipidOz: an Open-source Tool for Automated Elucidation of Lipid Double Bond Positions from Ozone-Induced Dissociation-IMS-MS Data

LipidOz: an Open-source Tool for Automated Elucidation of Lipid Double Bond Positions from Ozone-Induced Dissociation-IMS-MS Data

LipidOz: an Open-source Tool for Automated Elucidation of Lipid Double Bond Positions from Ozone-Induced Dissociation-IMS-MS Data.

LipidOz: Elucidation of Lipid Double Bond Positions IMS-MS

Ion Mobility (IM) advancements in Software, Data Bases, AI and Machine learning are quickly improving capabilities to make unknown identifications, separate and ID isomers, as well as improve workflows associated with metabolomics, lipidomics, PFAS, and qual-quant screening.
In addition, IM measurements are significantly improved with HRdm High Resolution Demultiplexing. This is the first commercial IM instrument to enable the simultaneous combination of high drift resolution, while at the same time achieving all four of the following measurement capabilities: broad mass range in a single injection, multiplexing to increase sensitivity, compatibility with fast chromatographic acquisition rates , and highest precision in CCS measurements. For more accurate CCS predictions, the better precision in the CCS training set improves AI machine learning SW. This can significantly reduce the number of potential candidate structures to select from when making unknown identifications.
<blockquote>
Presenter: James Dodds, PhD (University of North Carolina)
</blockquote>

Agilent Technologies: Innovative Data Analysis Strategies for Advancing Ion Mobility MS Workflows featuring Skyline, HRdm High Resolution Demultiplexing, and MetaboAnalyst

Innovative Data Analysis Strategies for Advancing Ion Mobility MS Workflows featuring Skyline, HRdm High Resolution Demultiplexing, and MetaboAnalyst

Innovative Data Analysis Strategies for Advancing Ion Mobility MS Workflows featuring Skyline, HRdm High Resolution Demultiplexing, and MetaboAnalyst.

Strategies for Advancing Ion Mobility MS Workflows

Many labs are faced with an ever-increasing sample load and changing regulations, plus the need to analyze increasingly complex data, while instrumentation and resources remain at a steady level.
As a consequence, instrument throughput and uptime are critical factors to maintain competitiveness and productivity. You need instruments that have evolved into complete solutions for meeting your current and future challenges.
You can meet your challenges with the new Agilent Revident quadrupole time-of-flight LC/MS system (LC/Q-TOF) and Agilent 6495 triple quadrupole LC/MS (LC/TQ). Their easy-to-use onboard intelligence, harmonized operation, and complete workflow capabilities let you look beyond instrumentation and expand your lab’s potential. So, you can focus on what inspires you and meet every challenge that comes your way.
What&#39;s in it for you?
<ul>
<li>Discover Next-Gen Instruments: Witness the intelligent Agilent Revident quadrupole time-of-flight LC/MS system (LC/Q-TOF) and the Agilent 6495 triple quadrupole LC/MS (LC/TQ). These are more than instruments – they&#39;re your keys to unmatched data precision and analysis.
</li>
<li>Elevate Your Lab&#39;s Potential: Say goodbye to outdated methods and welcome complete intelligent workflows. Picture a lab where time-consuming tasks are streamlined, complex data analysis becomes seamless, and your team can focus on what truly matters.
</li>
<li>Ignite Your Curiosity: Curious minds create transformative science. Learn from industry experts as they dive deep into the realm of instrument intelligence, AI-based tuning, and instrument telemetry. Gain insights into how you can maximize efficiency and enhance the capabilities of your lab.
</li>
</ul>
Who Should Attend? 
<ul>
<li>Lab Managers: Lead your lab into a new era of efficiency and productivity.
</li>
<li>Principle Investigators: Fuel your research with cutting-edge technology and insights.
</li>
<li>Senior Scientists: Stay ahead of the curve by harnessing the power of intelligent instrumentation.
</li>
</ul>

Agilent Technologies: LCMS Intelligence Unveiled - Shaping Futuristic Labs

LCMS Intelligence Unveiled - Shaping Futuristic Labs

Agilent Revident quadrupole time-of-flight LC/MS system (LC/Q-TOF) and Agilent 6495 triple quadrupole LC/MS (LC/TQ).

Monitoring the disinfection byproducts (DBPs) provides essential data to optimize drinking water treatment processes and is critical for compliance with drinking water regulations.
In this webinar, hear Mark Collins, the research and development manager at Northern Ireland Water, present his water catchment profiling study using high-resolution accurate mass spectrometer (HRAM) to screen for unknown disinfection byproducts (DBPs).
Mark&#39;s study initially started with monitoring known contaminants (Acid herbicides). However, following a succession of weather incidents in the catchment area under investigation, this study evolved into investigating the formation of potentially harmful DBPs resulting from the interaction of dissolved organic carbon and water treatment. Mark&#39;s talk is a short look at the present with a solid view for the future.
Learning points:
<ul>
<li>Workflows for unknown contaminant screening
</li>
<li>Generate more data from one injection
</li>
<li>Using HRAM to exceed water regulation requirements
</li>
</ul>
Who should attend:
<ul>
<li>Environmental water testing laboratories
</li>
<li>Laboratory scientists and technicians using LC-MS
</li>
<li>Water and environmental analytical chemistry laboratory managers
</li>
</ul>
<blockquote>
Presenter: Mark Collins (R&amp;D Manager, Northern Ireland Water)
</blockquote>
<blockquote>
Mark Collins has worked in the water industry for over 15 years. He is currently the R&amp;D Manager for Northern Ireland Water where he is focusing on new emerging areas of concern and innovative technologies to support our analytical service provision at NI Water. Mark’s interests are primarily in trace analysis of both organic and inorganic pollutants as well as the study of the creation disinfection by-products, their proliferation and effects on the wider water networks.
</blockquote>

Thermo Scientific: Non-targeted screening to assess drinking water treatment

Non-targeted screening to assess drinking water treatment

Water catchment profiling study using high-resolution accurate mass spectrometer (HRAM) to screen for unknown disinfection byproducts (DBPs).

LCMS webinars focusing on LC/HRMS - page 38