<div><div><div>Scientists at IOCB Prague have developed a breakthrough technology that streamlines aptamer development. The new method integrates several biochemical and bioinformatics steps and paves the way for new diagnostic and therapeutic applications. Ongoing applications include wearable sensors that monitor selected biomarkers in real time and provide early warnings of impending health complications. The findings were published in Nature Communications.</div></div><div>Aptamers are short DNA or RNA strands that can recognize and bind to a specific target molecule with high precision. Similar to antibodies, they can be used to detect these molecules or modulate their activity. Unlike antibodies, they are much more stable, can be produced synthetically, and can be chemically modified to achieve the desired properties. As a result, they can offer capabilities that cannot be achieved with antibodies.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg" alt="IOCHB Prague: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Chemically modified DNA aptamer bound to the target protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg 228w," sizes="100vw" width="1343" height="916">As demand grows for accurate and rapid diagnostic tools, aptamers are often better suited to these applications than antibodies. However, developing aptamers is both experimentally demanding and time-consuming. A team of scientists from IOCB Prague, led by Dr. Marek Ondruš and <a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en">Prof. Michal Hocek</a>, has now developed a technology that significantly shortens the development process.“Developing an aptamer is often like looking for a needle in a haystack. Among trillions of different DNA sequences, we search for the one that binds strongly and specifically to a target molecule. Our new approach first screen for ‘aptamer families’ – hundreds of related sequences – and then identify the best-performing member of the family. This approach can reduce development time from several months to only a few days,” says Marek Ondruš.<blockquote>Video:<a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=_3zXUeVMugU"> New technology streamlines the development of aptamers, synthetic alternatives to antibodies&nbsp;</a></blockquote>The team has also expanded the potential applications of aptamers by chemically modifying their building blocks. For example, introducing functional groups similar to those found naturally in amino acids allows the resulting molecules to combine the advantages of both DNA and antibodies: Their sequence is encoded by the order of nucleotides in DNA, while the attached chemical modifications greatly expand their ability to recognize biologically relevant targets and mimic interactions between proteins that are underlying many biological processes.The researchers demonstrated the potential of this new method using the human insulin receptor, a key protein that regulates blood sugar levels. They developed an aptamer that specifically binds to the receptor and elucidated the molecular basis of this interaction using cryo-electron microscopy. “We have shown that chemically introduced functional groups play a crucial role not only in target recognition and formation of the aptamer–protein complex, but also in stabilizing the DNA aptamer’s structure. Our findings provide new insights into how chemically modified nucleic acids can mimic key properties of proteins,” says Marek Ondruš.In the future, the technology could complement – or, in some applications, even replace – antibody-based diagnostic tools. Researchers are collaborating with <a target="_blank" rel="noopener noreferrer" href="http://iocbtech.cz/">IOCB Tech</a> on its further development, as the company helps to bring discoveries from IOCB Prague into practical applications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg" alt="IOCHB Prague/Tomáš Belloň: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Dr. Marek Ondruš, first author of the study, and Prof. Michal Hocek, head of the Bioorganic and Medicinal Chemistry of Nucleic Acids research group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg 234w," sizes="100vw" width="2000" height="1335"><blockquote><h4>Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-73676-y#citeas">Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries</a></h4>ablo Alberto Franco-Urquijo, Marek Ondruš, Jaroslav Kurfürst, Jana Škerlová, Irena Selicharová, Lucie Mužíková Čechová, Hana Šváchová, Alena Semerádtová, Anatolij Filimoněnko, Adéla Fejfarová, Jiří Homola, Tomáš Kouba &amp; Michal HocekNat. Commun., 2026<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41467-026-73676-y">https://doi.org/10.1038/s41467-026-73676-y</a>&nbsp;<h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable of identifying high-affinity modified aptamers. Double partition followed by amplification of eluted sequences, NGS analysis and clustering provides fast identification of aptamer candidates. Screening of modified DNA libraries containing modified adenine and uracil nucleotides bearing hydrophobic aromatic phenyl and indole moieties results in development of an aptamer binding human insulin receptor with sub-nanomolar affinity and exquisite specificity. Cryo-EM structure reveals the importance of each aromatic modification, either in stabilizing the secondary structure or facilitating interactions with the protein surface. This approach addresses the main drawbacks of aptamer selection and has potential for high-throughput screening and accelerating the development of next-generation aptamers for diagnostics or therapeutics.</div>

New technology streamlines the development of aptamers, synthetic alternatives to antibodies

Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity</a> 10.2 highlights</h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4>Instrument control modules</h4>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"><h4>MS data import/export improvements</h4>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"><h4>Obsolete hardware support terminated</h4>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"><blockquote>Explore the complete list of all changes, fixes, and additions in version 10.2.👉<a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">See the complete changelog&nbsp;</a></blockquote>

Clarity Chromatography Software 10.2 released!

🎤Dr. Leigh Terry (University of Alabama)In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.While most regulatory methods focus on a small number of compounds like PFOA and PFOS, there may be thousands of PFAS compounds in the environment—and much of that burden goes undetected.<h4>In this episode, we cover:</h4><ul><li>Why PFAS are called “forever chemicals” (and why that label is evolving)</li><li>The limitations of targeted LC-MS/MS methods</li><li>What the fluorine mass balance problem reveals about PFAS destruction</li><li>How combustion ion chromatography (CIC) helps measure total organofluorine</li><li>Why “99.99% removal” doesn’t always mean what you think</li><li>Where PFAS actually end up in wastewater treatment systems</li><li>The most effective technologies for PFAS removal today</li><li>Why drinking water may only account for ~20% of total PFAS exposure</li></ul><h4>Key Insight:</h4>Even when analyzing dozens of PFAS compounds, researchers may only be capturing a small fraction of total organic fluorine—raising major questions about how we monitor and regulate these contaminants.<h3>Video Transcription</h3>In this episode of Concentrating on Chromatography, Dr. Leigh Terry discusses PFAS contamination in drinking water, the analytical challenges associated with measuring these compounds, current treatment technologies, and future directions for monitoring and regulation. The conversation highlights how analytical chemistry, environmental engineering, and public health intersect in addressing one of today's most discussed classes of emerging contaminants.<h4>Understanding PFAS and Their Significance</h4><h5>The University of Alabama Water Quality Research Center</h5>Dr. Leigh Terry is part of the University of Alabama's Center for Water Quality Research. The center operates an analytical laboratory focused on drinking water quality and the detection of contaminants at extremely low concentrations.The laboratory specializes in:<ul><li>Drinking water analysis</li><li>Organic contaminants</li><li>Emerging contaminants</li><li>PFAS monitoring</li><li>Water quality research</li></ul>Their work supports both research initiatives and practical solutions for water utilities and environmental agencies.<h4>Why Focus on PFAS?</h4>Although PFAS compounds have existed since the 1940s, public awareness has increased dramatically only in recent years.According to Dr. Terry, several factors contributed to the rapid growth of PFAS research:<ul><li>Increased media attention</li><li>New regulatory initiatives</li><li>Growing evidence of human exposure</li><li>Expanding research opportunities</li><li>Greater understanding of potential health risks</li></ul>PFAS are not new contaminants. Rather, society is only beginning to understand their prevalence in the environment and their potential impacts on human health.<h4>The Development of Standardized PFAS Methods</h4>One major advancement in PFAS analysis has been the development of standardized EPA methods.These methods allow:<ul><li>Consistent testing procedures</li><li>Comparable results between laboratories</li><li>Regulatory monitoring</li><li>Reliable data interpretation</li></ul>Dr. Terry notes that many of these standardized approaches began appearing around 2018–2019, providing a common framework for analytical laboratories and researchers.<h4>How Large Is the PFAS Universe?</h4>Many people are familiar with PFOA and PFOS, two of the most heavily studied PFAS compounds. However, these represent only a small fraction of the broader PFAS family.PFOA and PFOS are often referred to as:<ul><li>Legacy PFAS compounds</li><li>Original PFAS contaminants</li><li>Early commercial PFAS chemicals</li></ul>The challenge is that even minor modifications to molecular structure create entirely new PFAS compounds.Researchers estimate:<ul><li>Thousands of PFAS compounds exist</li><li>Some estimates exceed 10,000 compounds</li><li>Exact numbers depend on how PFAS are defined</li></ul>Scientific debate continues regarding classification and definition, making precise counting difficult.<h4>Why PFAS Are Called "Forever Chemicals"</h4>Dr. Terry notes that the phrase "forever chemicals" has become widely used, although she suggests the terminology could benefit from rebranding.PFAS persistence results from two key chemical properties.<h5>1. Amphiphilic Structure</h5>PFAS molecules contain:<ul><li>A water-loving (hydrophilic) head group</li><li>A water-repelling (hydrophobic) fluorinated tail</li></ul>This unusual combination allows PFAS to partition between:<ul><li>Water</li><li>Solids</li><li>Air-water interfaces</li><li>Foam</li></ul>Unlike many organic compounds, PFAS can interact effectively with multiple environmental phases.<h5>2. Extremely Strong Carbon–Fluorine Bonds</h5>The carbon–fluorine bond is among the strongest bonds in organic chemistry.As Dr. Terry explains:<ul><li>Large amounts of energy are required to break these bonds</li><li>Natural degradation processes are often ineffective</li><li>Destruction can require highly aggressive treatment conditions</li></ul>These properties make PFAS extremely persistent in both environmental systems and biological organisms.<h4>Toxicity, Regulations, and Environmental Behavior</h4><h5>Understanding PFAS Toxicity</h5>One of the biggest challenges in PFAS regulation is the incomplete understanding of toxicity.Dr. Terry explains that EPA regulations generally consider three factors:<ul><li>Presence in drinking water sources</li><li>Toxicity to humans</li><li>Availability of practical treatment options</li></ul>While some PFAS compounds are known to be harmful, many others remain insufficiently studied. Furthermore, PFAS often occur as mixtures rather than individual compounds.This creates important scientific questions:<ul><li>What is the toxicity of individual PFAS?</li><li>What is the toxicity of PFAS mixtures?</li><li>How should cumulative exposure be evaluated?</li></ul>These uncertainties continue to drive active research.<h4>What Happens to PFAS in Wastewater Treatment Plants?</h4>PFAS do not behave like many conventional contaminants.Rather than remaining fully dissolved in water, they often accumulate at interfaces such as:<ul><li>Water-solid interfaces</li><li>Water-air interfaces</li><li>Foam layers</li><li>Biological solids</li></ul>As a result:<ul><li>Some PFAS accumulate in biosolids</li><li>Some partition into foam</li><li>Some remain in treated effluent</li></ul>Their distribution depends on wastewater composition and treatment processes.<h4>Regulatory Monitoring and Targeted LC-MS Analysis</h4>Current EPA regulations focus on targeted analysis of specific PFAS compounds.Examples include:<ul><li>PFOA</li><li>PFOS</li></ul>Drinking water regulations currently establish maximum contaminant levels (MCLs) for these compounds at extremely low concentrations.Advantages of targeted LC-MS analysis include:<ul><li>Clearly defined analytes</li><li>Established regulatory limits</li><li>High analytical sensitivity</li><li>Reliable quantitation</li></ul>However, limitations remain:<ul><li>Only a small subset of PFAS is measured</li><li>Many PFAS compounds remain undetected</li><li>Total PFAS burden may be underestimated</li></ul>As Dr. Terry notes, targeted analysis provides only part of the overall picture.<h4>The Fluorine Mass Balance Problem</h4>One of the most important concepts discussed in the interview is fluorine mass balance.When PFAS degrade, fluorinated fragments may remain in the environment.This creates a critical question:Are treatment technologies truly destroying PFAS, or merely transforming them into shorter-chain PFAS compounds?To answer this, researchers perform fluorine mass balance calculations using:<ul><li>Targeted PFAS analysis</li><li>Fluoride measurements</li><li>Total organic fluorine measurements</li></ul>A successful destruction process should ultimately convert PFAS into fluoride ions rather than simply producing smaller PFAS molecules.<h4>Advanced Analysis, Treatment Technologies, and Future Directions</h4><h5>Combining Targeted and Bulk Fluorine Measurements</h5>Dr. Terry's group complements targeted LC-MS analysis with measurements of total organic fluorine.Approaches include:<ul><li>Absorbable Organic Fluorine (AOF)</li><li>Extractable Organic Fluorine (EOF)</li><li>Combustion Ion Chromatography (CIC)</li></ul>In these methods:<ul><li>Organic fluorine is captured</li><li>Samples are combusted</li><li>Released fluoride is quantified</li></ul>This provides insight into total fluorinated content, although contributions may originate from sources beyond PFAS, including pharmaceuticals and consumer products.<h4>Surprising Findings from Combined Analysis</h4>One important finding from wastewater studies was that targeted PFAS measurements accounted for only a small fraction of total organic fluorine.Dr. Terry reports that:<ul><li>Approximately 4% of measured AOF could be explained by targeted PFAS compounds</li><li>The majority of organic fluorine remained unidentified</li></ul>This suggests that environmental fluorine chemistry is considerably more complex than currently represented by routine monitoring programs.<h4>Preventing PFAS Contamination in the Laboratory</h4>PFAS analysis requires exceptionally strict quality control.Dr. Terry's laboratory routinely:<ul><li>Tests every new batch of SPE cartridges</li><li>Tests carbon tubes before use</li><li>Uses DI water blanks</li><li>Verifies consumables labeled as PFAS-free</li><li>Collects field blanks</li><li>Monitors analytical blanks throughout workflows</li></ul>These practices help prevent contamination from laboratory materials and consumables, a common challenge in ultra-trace PFAS analysis.<h4>Current PFAS Treatment Technologies</h4>Three technologies currently dominate PFAS removal in drinking water treatment:<ul><li>Granular Activated Carbon (GAC)</li><li>Ion Exchange Resins</li><li>Reverse Osmosis (RO)</li></ul>Selection depends on:<ul><li>PFAS concentration</li><li>Water quality</li><li>Local operating conditions</li><li>Utility infrastructure</li></ul>Although many emerging technologies are being investigated, these remain the most widely implemented solutions.<h4>Membrane Filtration and Pretreatment</h4>Dr. Terry collaborates with colleagues studying membrane-based PFAS treatment.Her own work focuses on pretreatment through biological filtration.The strategy involves:<ul><li>Removing natural organic matter</li><li>Reducing membrane fouling</li><li>Improving membrane performance</li><li>Extending operational efficiency</li></ul>This integrated approach demonstrates how multiple treatment technologies can work together to improve PFAS removal.<h4>Regional Monitoring Projects</h4>The University of Alabama team participates in EPA-supported monitoring efforts along the Gulf Coast.Their observations indicate:<ul><li>PFAS rarely occur alone</li><li>Multiple PFAS compounds frequently co-occur</li><li>Contamination often originates from identifiable point sources</li></ul>Examples include:<ul><li>Industrial facilities</li><li>Manufacturing operations</li><li>Military installations</li><li>Carpet manufacturing facilities</li></ul>Source identification remains a critical component of environmental monitoring programs.<h4>Future Directions for PFAS Monitoring</h4>Looking ahead, Dr. Terry sees several opportunities for improvement.Desired advances include:<ul><li>In situ monitoring technologies</li><li>Portable detection systems</li><li>Reduced analytical complexity</li><li>Lower instrument costs</li><li>Less expensive consumables</li><li>Faster analysis workflows</li></ul>Current PFAS testing requires substantial expertise, specialized instrumentation, and rigorous quality control, making widespread implementation challenging.<h4>Dr. Terry's Perspective on Long-Term Solutions</h4>When asked what major PFAS challenge she would most like to solve, Dr. Terry offered a broader perspective.Rather than focusing solely on remediation, she emphasized prevention.Her view is that society should:<ul><li>Better evaluate chemical toxicity before commercialization</li><li>Assess risks before large-scale deployment</li><li>Reduce introduction of harmful compounds into the environment</li><li>Support utilities tasked with contaminant removal</li></ul>She notes that water utilities often bear the responsibility of removing contaminants they did not create, highlighting the need for broader societal and regulatory support.<h4>Final Thoughts</h4>Dr. Terry encourages consumers to:<ul><li>Learn where their drinking water originates</li><li>Read annual water quality reports</li><li>Stay informed about local water quality</li><li>Consider appropriate home filtration where needed</li></ul>At the same time, she emphasizes confidence in municipal water systems and the importance of continued investment in water quality research, monitoring, and treatment technologies.<h4>Conclusion</h4>PFAS remain one of the most complex challenges in environmental chemistry and water treatment. Through advanced analytical methods such as LC-MS/MS, combustion ion chromatography, fluorine mass balance approaches, and large-scale monitoring programs, researchers like Dr. Leigh Terry are helping improve our understanding of these persistent contaminants.The interview highlights that solving the PFAS challenge will require a combination of better analytical tools, improved treatment technologies, stronger regulatory frameworks, and a greater emphasis on prevention before contaminants enter the environment.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

PFAS in Water: Why We’re Missing 96% of the Problem

Article

Product

Video

Scientists

Environment

Water

Interview

Science and research

Software

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Metrohm

Mettler-Toledo

Thermo Fisher Scientific

Wiley

In this webinar Dr Julia van Drunen introduces electrochemical impedance spectroscopy (EIS) as a valuable tool for the analysis of battery materials, components, and fuel cells.
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Presenter: Julia van Drunen, PhD (Area Sales and Marketing Manager, Metrohm Autolab)
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Metrohm: EIS Data For Battery Materials R&D

EIS Data For Battery Materials R&D

Electrochemical impedance spectroscopy (EIS) as a valuable tool for the analysis of battery materials, components, and fuel cells.

Noisy Signal? Sloping Baseline? Current Spikes? Electrochemistry can be tough to get right sometimes, so join us for this free-to-attend webinar and learn step-by-step processes on how to troubleshoot everyday problems you might have encountered before in the lab.
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Presenter: Dr. James Taylor (Application Scientist, Metrohm Autolab)
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Metrohm USA: Troubleshooting Electrochemical Systems

Troubleshooting Electrochemical Systems

Learn step-by-step processes on how to troubleshoot everyday problems you might have encountered with electrochemistry

This webinar is offered several times. Select the date and time that works best for you.
<ul>
<li>Tue, Mar 19, 2024, 10:00 AM - 11:00 AM CET</li>
<li>Tue, Mar 19, 2024, 3:30 PM - 4:30 PM CET</li>
</ul>
Ever wondered about what&#39;s inside your potentiostat and whether it really matters? In this webinar we&#39;ll answer questions you&#39;ve always wanted to ask, explain how a potential is applied or a current measured in a conventional three-electrode setup. Do you know what the compliance voltage or the bandwidth of the instrument is, and why one should care?
With a good understanding of how the instrument is made and operates you’ll be able to make sense of the data it provides, troubleshoot common electrochemical experiments, and boost your confidence in the lab. 
This webinar is accessible to anyone: no background in electronics is required. 
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Presenter: Thomas Touzalin, PhD. (Product Manager at Metrohm Autolab)
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Helping the electrochemistry researchers achieve their goals by providing the right solution for any research problems as well as offering technical support for the Autolab product range.
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Surprise: We will be giving away the &quot;A guide to flawless electrochemical measurements&quot; lab poster, a step-by-step guide to address common issues you may encounter when using a potentiostat. You can hang it in your lab to ensure the success of every experiment. If you would like to stand a chance to win one through a lucky draw, please indicate below.

Metrolab: Beyond the black box: how a potentiostat works

Beyond the black box: how a potentiostat works

In this webinar we'll explain how a potential is applied or a current measured in a conventional three-electrode setup.

Event Program
<ul>
<li>Introduction</li>
<li>Temperature effects on sensors</li>
<li>Temperature effects on buffers/solutions</li>
<li>Temperature compensation on the part of the sensor</li>
<li>Temperature compensation on the part of the buffers</li>
<li>Summary</li>
<li>Q&amp;A and feedback</li>
</ul>
The temperature plays a critical role in pH measurements. Achieving accurate pH values is not only about the chemical composition of a solution but also about understanding the impact of temperature fluctuations. Temperature can significantly influence the behavior of pH electrodes and the characteristics of the sample, making it essential to understand its effects on pH measurements. Challenges arise when temperature differentials between the electrode and the sample lead to unstable readings, highlighting the need for a deeper understanding of temperature&#39;s influence on pH.
During our webinar, you will learn about the relationship between temperature and pH. From the temperature dependence of the dissociation constant of water to the impact of temperature on the activity coefficient and acid constants, we will see the complexities of temperature effects on pH measurements. Understanding these nuances can help you enhance the accuracy and reliability of your pH measurements, ensuring precise results across diverse temperature conditions.
Register now for our upcoming webinar to gain valuable insights into the effect of temperature on pH and deepen your understanding of this relationship. Join us and gain the knowledge to optimize your pH measurements and achieve consistent, reliable results.
<h5>How does temperature affect pH measurements?</h5>
Temperature can significantly impact pH measurements by altering the behavior of pH electrodes and the characteristics of the sample. Temperature changes can cause the pH electrode to drift until the temperature of the electrode and the sample become equal, leading to unstable readings. Additionally, the temperature dependence of the dissociation constant of water and the solution&#39;s activity coefficient and acid constants can cause changes in the H+ concentration and real pH value changes.
<h5>How can I compensate for temperature effects on pH measurements?</h5>
Temperature compensation tables have been determined for standard buffer solutions, which can be programmed into pH meters to ensure the correct pH value is used for the buffer at the temperature at which the calibration is performed. However, it is almost impossible to compensate for the temperature coefficient of every sample solution, making it essential to measure samples at the same temperature to make accurate comparisons.
<h5>What are the best practices for handling pH electrodes in temperature-sensitive environments?</h5>
To ensure accurate pH measurements in temperature-sensitive environments, it is crucial to use the correct pH electrode for the specific sample and give the electrode enough time to equilibrate and to maintain the electrode properly.
When measuring in samples that do not consist of easy-to-measure clear, aqueous solutions, problems of electrical or chemical origin can occur, which should be addressed by following the manufacturer&#39;s instructions for electrode handling and maintenance.
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Presenter: Dr Reena Mascarenhas
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Reena is an electrochemist, working for METTLER TOLEDO, with over five years of experience in training others in various aspects of the field. Her in-depth understanding, technical expertise, and engaging and informative training style make her a prominent speaker for this webinar.
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Mettler-Toledo: Temperature Effects on pH Measurement

Temperature Effects on pH Measurement

A Live Webinar to Understand the Relation between Varying Temperature and pH.

<h5>Event Program</h5>
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<li>What exactly is data integrity for electronic record keeping and how does it affect process instrumentation for pharmaceutical water systems?</li>
<li>How can a transmitter and software combination help pharmaceutical companies implement data integrity?</li>
</ul>
<h5>Easy Data Integrity Implementation</h5>
In this live webinar, we will discuss what data integrity for electronic record keeping is and how it impacts process instrumentation for pharmaceutical water systems. 
The presenter will also introduce updates and additions to the RecordLOC transmitter and PC software, the METTLER TOLEDO Thornton solution for implementing data integrity for TOC, ozone, and conductivity in pharmaceutical water systems. 
See how RecordLOC helps pharmaceutical companies easily implement data integrity.
Attendees will have the opportunity to ask the presenter your questions about electronic record keeping.
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Presenter: Joel Kenyon (Senior Global Product Manager for Conductivity and Transmitters for METTLER TOLEDO Thornton.)
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Joel Kenyon is the Senior Global Product Manager for Conductivity and Transmitters for METTLER TOLEDO Thornton. A biologist by training, for the last 15 years Joel has developed and supported analytical instrumentation for academic and industrial applications across a broad range of disciplines.
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Mettler-Toledo: Data Integrity Requirements For Process Instrumentation

Data Integrity Requirements For Process Instrumentation

We will discuss what data integrity for electronic record keeping is and how it impacts process instrumentation for pharmaceutical water systems.

For years, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) has been the go-to method for protein purity analysis. Despite shortcomings in sensitivity, reproducibility, and its semi-quantitative nature, SDS-PAGE is still widely used.
Capillary electrophoresis (CE-SDS) with its superior separation power, accurate quantitation, and ability for automation is quickly replacing SDS-PAGE in laboratories around the world. In addition to the obvious advantages in time and labor, CE-SDS also stands out as a ‘greener’ method over SDS-PAGE. As laboratories worldwide increasingly focus on waste management with various methods, CE-SDS presents clear advantages over SDS-PAGE for protein purity analysis.​
In this webinar, Prof. Hermann Wätzig from the Institute of Medicinal and Pharmaceutical Chemistry, Braunschweig, Germany and Dr. Chris Heger, Director, Applications Science, Bio-Techne will discuss how transitioning from SDS-PAGE to CE-SDS benefits research, both from an academic and industrial perspective. The speakers will also discuss the current state-of-the art instrumentation and method development landscape.
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Presenter: Dr. Hermann Wätzig (Professor, Technische Universität Braunschweig)
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Presenter: Dr. Chris Heger (Director, Applications Science, Bio-Techne)
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Wiley: Time to Turn the PAGE on SDS-PAGE!

Time to Turn the PAGE on SDS-PAGE!

Transitioning from SDS-PAGE to CE-SDS benefits research, both from an academic and industrial perspective.

Achieving product consistency for beer, wine, cider, and other adult beverages requires the analysis of multiple parameters using several automated and/or wet chemistry procedures.
Many labs still follow the traditional wet chemical methods like colorimetry, titration, and flow analysis, as well as measurement methods such as pH, conductivity, and ion selective electrodes. Integrated discrete analysis consolidates beverage testing and simultaneously automates the analysis of critical parameters resulting in faster turnaround, reduced human error, lower reagent use, and expanded laboratory analytical capabilities. Better testing means better product to retain and expand your customer base. We will present an overview of the integrated discrete analyzer and important parameters to measure in adult beverages.
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Presenter: Hari Narayanan (Product Marketing Manager, Thermo Fisher Scientific)
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Dr. Hari Narayanan is the Product Marketing Manager at Thermo Fisher Scientific. He has nearly 20 years of experience in managing research activities and applications development. He collaborates with regulatory agencies like ASTM, EPA, EPRI, USP, and AOAC and has been part of several new method developments. He is well-versed in multivariate analysis, sample preparation, titration, ion chromatography, Combustion IC, molecular spectroscopy (FTNIR, FTIR, RAMAN and UV), voltammetry, flash chromatography, particle size analysis, ICP and XRF. He received his B.Sc and M.Sc. in Chemistry from the Madurai Kamaraj University and a Ph.D. in Analytical Chemistry from the University of Madras, India. Before joining Thermo Fisher Scientific, Hari was Director of Strategic Marketing at Metrohm USA.
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Thermo Scientific: Consistent Quality from Consolidated Beverage Testing

Consistent Quality from Consolidated Beverage Testing

Overview of the integrated discrete analyzer and important parameters to measure in adult beverages.

Wet chemical methods are an integral part of modern analytical labs. Many of the regulatory bodies, such as the US EPA, recommend wet chemical methods like colorimetry, titrimetry, and flow analysis, as well as measurement methods like pH, conductivity, and ion selective electrodes for drinking water and wastewater applications.
Why? Because wet chemical methods are proven and modern instrumentation often cannot determine results that many specific wet chemical tests provide. However, these traditional wet chemical methods are tedious, time-consuming, and consume large volumes of samples and reagents.
In this webinar we will provide an overview of US EPA recommended automated wet chemical methods for drinking water and wastewater and discuss several application examples that highlight the benefits of transferring traditional wet chemical methods to the integrated discrete analyzer.
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Presenter: David Glutz (Product Specialist, Thermo Fisher Scientific)
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David Glutz has been working at Thermo Fisher Scientific as a Product Specialist for 12 years. He has strong working and method development knowledge and is the go-to person for the Discrete Analyzer product line. David supports customer training and application development for discrete analyzers, ion chromatography, and sample preparation at the Center of Excellence. Trained in Applied Chemical Technology from the University of Cincinnati’s OMI College of Applied Science, David has a unique background in the environmental field with more than 20 years of experience.
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Thermo Scientific: Automated Environmental Wet Chemical Analysis

Automated Environmental Wet Chemical Analysis

Overview of US EPA recommended automated wet chemical methods for drinking water and wastewater and discuss several application examples.

Conventional wet chemistry is manual, labor intensive, and involves large sample volumes.
We will show how a discrete analyzer enables simultaneous multi-parameter analysis and discuss how fully automated wet chemistry analysis in microliter-scale provides cost efficiency and complements ion chromatography.
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Presenter: Hari Narayanan (Product Marketing Manager, Discrete Industrial Analyzer, Thermo Fisher Scientific)
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Dr. Hari Narayanan has nearly 20 years of experience in managing research activities and applications development. He collaborates with regulatory agencies and has been part of several new method developments. He is well-versed in multivariate analysis, sample preparation, titration, ion chromatography, molecular spectroscopy (FTNIR, FTIR, RAMAN and UV), and voltammetry. He received his B.Sc. and M.Sc. in Chemistry from the Madurai Kamaraj University and a Ph.D. in Analytical Chemistry from the University of Madras, India.
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Thermo Scientific: Automate Your Wet Chemistry Analysis

Automate Your Wet Chemistry Analysis

How a discrete analyzer enables simultaneous multi-parameter analysis.

Adoption of cloud-based LIMS solutions continues to grow, as laboratories across all industries consider the financial and operational benefits of cloud-based solutions.
For new laboratories implementing a LIMS for the first time, cloud can provide a quick road to go-live with low capital expenditure and minimal resources to run and manage the system. For existing laboratories looking to modernize their LIMS implementation, cloud can help minimize IT costs while providing unmatched scalability. In this session, we’ll explore real-world customer stories of laboratories that selected cloud deployments for their Thermo Scientific™ SampleManager LIMS™ software.
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Presenter: Katie Evans (Senior Product Manager, Digital Science, Thermo Fisher Scientific)
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Katie Evans is a Senior Product Manager for the Digital Science business at Thermo Fisher Scientific and is located in Altrincham, in the Manchester area of the UK. During her 22 years at Thermo Fisher Scientific, Katie has focused on product management and strategy development of Laboratory Information Management Systems (LIMS) software with an emphasis on the needs of laboratories serving regulated markets. Katie received her Master of Science degree from Exeter University, UK.
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Presenter. Jon Webb (Senior Sales Manager, Digital Science, Thermo Fisher Scientific)
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Jon Webb has been with Thermo Fisher Scientific since 2014. His career has focused on helping global R&amp;D organizations manage their scientific data effectively and his work experience has provided him a deep understanding of the benefits of deploying enterprise software to the cloud. His work at Thermo Fisher Scientific has focused on implementing enterprise software solutions to support complex processes and business objectives across the Oil &amp; Gas industry.
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Thermo Scientific: Software to Drive Your Science - Why Some Oil & Gas Companies are Looking to the Cloud

Software to Drive Your Science - Why Some Oil & Gas Companies are Looking to the Cloud

Real-world customer stories of laboratories that selected cloud deployments for their Thermo Scientific™ SampleManager LIMS™ software.

LCMS webinars focusing on Electrochemistry - page 4