<div>Mulching films used in agriculture gradually break down and can become a significant source of microplastics in soils. A new study shows that these particles affect not only soil structure but also microbial life and nitrogen cycling.“We wanted to understand how microplastics from both conventional and biodegradable mulching films influence soil properties, microbial diversity and functions in real conditions,” explains Klára Šmídová, the study’s co-author . “That’s why we added realistic amounts of microplastics to soils in experimental plots in Finland, Germany, and Spain, monitored them over two growing seasons, and compared them with the control plots.”The results revealed that microplastics alter soil characteristics and microbial communities, although not always in the same way. “ However, a consistent finding was the decline in microbial activity associated with key processes, including nitrogen cycling, with negative effects increasing at higher microplastic concentrations and becoming more pronounced in the second year,” Šmídová adds. Because the microplastic levels used in the study reflect amounts already found in European soils, the findings highlight real risks to soil health. “We also found that the effects were stronger in southern than in northern Europe, likely due to differences in climate and soil conditions. This means that protecting soils from plastic pollution will require region-specific risk assessments,” she says.Over 60% of European soils are estimated to be unhealthy, with ongoing degradation driven by unsustainable land use, contamination, climate change, and extreme weather events. In response, the EU Parliament adopted the Soil Monitoring Law in October 2025, aiming to achieve healthy soils across Europe by 2050. “The law highlights the role of soil health in food security, water quality, and climate objectives, and establishes consistent soil monitoring across Member States. It includes measures to support farmers and foresters, while also creating a public list of potentially contaminated sites and an indicative watch list of emerging soil contaminants,” explains Klára Šmídová.The project brought together 19 research groups across Europe. “After each season, hundreds of samples were colle cted and sent to partners for analysis. This paper focuses on soil properties, microbial diversity, and greenhouse gas emissions. Two more manuscripts—on plastic additives and microplastic fate, and on soil invertebrates—are in preparation. Together, they will give us a complete picture of how agricultural microplastics affect soil ecosystems,” concludes Klára Šmídová.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg" alt="RECETOX: New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg 171w," sizes="100vw" width="738" height="674"><blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0269749125015866?via%3Dihub#sec2">Conventional and biodegradable agricultural microplastics: effects on soil properties and microbial functions across a European pedoclimatic gradient</a></h4>Šmídová K., Soinne H., Kim S. W., Tirronniemi J., Meffe R., Redondo-Hasselerharm P. E., Braun M., Rillig M. C., Fritze H., Adamczyk B., Nikama J., Kaseva J., Saartama V., Amelung W., Hurley R., Hofman J., Nizzetto L., Selonen S., Velmala S.Environ. Pollut. 386 (2025) 127212<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.envpol.2025.127212">10.1016/j.envpol.2025.127212</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4><div>Agricultural plastics like mulching films may become a major source of microplastic (MP) soil contamination during their degradation and fragmentation. This study investigates the effects of agricultural MPs from conventional (linear low-density polyethylene, PE) and biodegradable (starch-blended polybutylene adipate co-terephthalate, PBAT-BD) mulching films on soil physicochemical properties, aggregation, microbial diversity and functions, litter decomposition, and greenhouse gases emissions (GHG). For this purpose, MPs were mixed into soils at realistic MP concentrations of 0.005&nbsp;% and 0.05&nbsp;% (w/w) in 2022 on experimental plots in three EU countries representing different pedoclimatic conditions (Finland, Germany and Spain), followed by monitoring of the above-mentioned variables in the subsequent growing seasons 2022 and 2023. We found several significant MP-induced effects for soil properties, aggregation, microbial diversity, litter decomposition, and GHG, but the effect endpoints were less pronounced or varied considerably. Contrarily, microbial activity, contributing to soil functions such as nitrogen cycling, was consistently reduced by both conventional and biodegradable MPs. The reductions were more pronounced after the second season and for the higher MP treatment. As the higher MP concentration (i.e., 0.05&nbsp;% w/w) is environmentally relevant in Europe, our findings emphasize the potential effects of environmentally relevant MP concentrations on soil health. Furthermore, the effects increased from north to south, probably modulated by varying pedoclimatic conditions, inducing reflection of a need for regionally tailored risk</div></div>

New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions

<h3>Charged for Action: The Hidden Secrets of AEX Oligonucleotide Analysis</h3>Oligonucleotides—short, well-defined fragments of DNA or RNA—have become indispensable tools in modern life sciences. They underpin cutting-edge applications in molecular diagnostics, gene therapy, and pharmaceutical development. Before oligonucleotides can be confidently used in research or clinical settings, however, their quality must be rigorously assessed. Purity, sequence integrity, length distribution, and chemical modifications all play a decisive role in their performance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg" alt="KNAUER: Oligos Made Easy - Part 2: AEX" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg 245w," sizes="100vw" width="1534" height="711">Among the analytical techniques available today, anion exchange chromatography (AEX) stands out as a robust and highly informative method for characterizing oligonucleotides. By exploiting their intrinsic negative charge, AEX provides detailed insight into product composition and impurity profiles that are difficult to obtain by other approaches.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6808">Part 1 of the Oligos series: A Practical Guide to Oligonucleotide Production – From Concept to Final Product</a></blockquote><h4>How Scientists Read Oligonucleotides Using Charge</h4>At the core of AEX lies a simple but powerful principle: oligonucleotides carry a negatively charged phosphate backbone. This charge increases in a predictable way with strand length and, to a lesser extent, sequence composition. Anion exchange chromatography uses this property to separate oligonucleotides based on differences in charge strength and interaction with a positively charged stationary phase.As a result, AEX has become one of the most widely used analytical tools for evaluating oligonucleotide quality. It allows scientists to distinguish full-length products from truncated species, degradation products, or closely related variants—often with single-nucleotide resolution.<h4>Why Ion Exchange Works: Binding, Retention, and Release</h4>Ion exchange chromatography (IEX) relies on electrostatic interactions between analytes and a charged stationary phase. In the case of oligonucleotides, anion exchange is used, where negatively charged molecules interact with positively charged functional groups on the resin—most commonly quaternary amines.The system consists of two main components:<ul><li>Stationary phase: A positively charged resin that binds anionic analytes.</li><li>Mobile phase: An aqueous buffer system, typically combined with a salt gradient, that controls both pH and elution strength.</li></ul>Retention in AEX is governed primarily by charge. Molecules with weaker overall charge interact less strongly with the stationary phase and elute earlier, while more highly charged oligonucleotides bind more tightly and require stronger elution conditions.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 1 IEX overview including elution order dependency on analyte charge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg 245w," sizes="100vw" width="1583" height="654"><h4>The Five-Step Workflow of Ion Exchange Chromatography</h4>AEX separations generally follow a well-established sequence of steps:<ol><li>Column equilibration The column is conditioned with the starting buffer until the baseline and pH are stable. This ensures that all charged sites on the resin are ready for interaction.</li><li>Sample loading Samples, prepared in the starting buffer, are introduced under conditions that promote binding of the target oligonucleotides while minimizing retention of unwanted impurities.</li><li>Washing The column is washed with the starting buffer to remove uncharged or weakly interacting components. The baseline stabilizes as these species are flushed away.</li><li>Elution Bound oligonucleotides are released using a salt or pH gradient. Increasing ionic strength introduces competing ions that displace the analytes from the resin. Weakly bound species elute first; strongly charged oligonucleotides elute later.</li><li>Regeneration and re-equilibration A high-salt buffer removes any remaining bound material. The column is then returned to starting conditions in preparation for the next analysis.</li></ol><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 2 Five steps of IEX procedure (in blue), outlined using an example chromatogram (in red)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg 245w," sizes="100vw" width="1583" height="674"><h4>Why AEX Is Especially Effective for Oligonucleotides</h4>The repeating phosphate backbone of oligonucleotides gives rise to a strong and uniform anionic character across a wide pH range (typically pH 7–9). This makes oligonucleotides exceptionally well suited for anion exchange separations.Key factors influencing AEX behavior include:<ul><li>Charge density: Longer oligonucleotides carry more negative charges and therefore exhibit stronger retention.</li><li>Resin chemistry: Strong and weak anion exchangers differ in functional groups and pH stability, influencing selectivity and robustness.</li><li>Buffer composition: The choice of buffering ions and salt gradients directly affects elution strength and resolution.</li></ul>Salt gradients—commonly based on chloride ions—compete with the oligonucleotide backbone for binding sites on the resin. By carefully tuning gradient slope and composition, analysts can achieve highly reproducible and finely resolved separations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 3 Ionic interactions and pH influence on Anion Exchange Chromatography (AEX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg 245w," sizes="100vw" width="1547" height="593"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 4 AEX buffer selection and gradient strategy (chromatogram with red buffer gradient curve)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg 245w," sizes="100vw" width="1600" height="327"><h4>AEX as the Gold Standard for Oligonucleotide Separation</h4>Anion exchange chromatography has become the method of choice for both analytical and preparative oligonucleotide workflows. Its advantages include:<ul><li>High resolving power: Closely related impurities, including n–1 or n–2 species, can often be separated and quantified.</li><li>Predictable retention behavior: In many cases, retention time correlates linearly with oligonucleotide length, simplifying identification.</li><li>Compatibility with modified oligonucleotides: Even chemically modified sequences retain their anionic nature, allowing AEX to resolve both products and related impurities.</li><li>Excellent control via gradient elution: Salt gradients provide precise tuning of selectivity and resolution.</li></ul>Typically, shorter or degraded oligonucleotides elute at lower ionic strength, while full-length products with higher charge density appear later in the chromatogram.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 5 AEX Advantages and Challenges." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg 245w," sizes="100vw" width="1535" height="707"><h4>Final Perspective: Mastering AEX with Confidence</h4>Anion exchange chromatography may appear complex at first, but with thoughtful optimization of pH, buffer composition, and gradient conditions, it becomes a highly precise and reliable tool for oligonucleotide analysis. When properly applied, AEX delivers sharp peaks, excellent resolution, and robust performance—even for challenging sequences and modifications.For laboratories developing or refining oligonucleotide workflows, AEX offers both analytical depth and operational confidence.<blockquote>If you would like to discuss AEX method development or optimization for oligonucleotides, feel free to contact us at sales@knauer.net. More insights into practical oligonucleotide analysis will follow in our “Oligos Made Easy” series.For technical questions or in-depth discussion, the author can be reached at kindler@knauer.net</blockquote>

Oligos Made Easy - Part 2: AEX

News from LabRulezLCMS Library - Week 07, 2026

Article

Application

Plastics

Environment

Science and research

Poster

RECETOX (Research Centre for Toxic Compounds in the Environment) is an independent department of the Faculty of Science of Masaryk University in Brno, which has been established in 1983. RECETOX is focused on the research and education in cross-cutting area of Environment and Health. It addresses interactions among chemicals, environment, and biological systems, including consequences at local, regional, and global levels.

RECETOX - Centrum pro výzkum toxických látek v prostředí

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Separation Science

Agilent Technologies

Technology Networks

Bruker

SelectScience

Wiley

SCIEX

Waters Corporation

Join us on Thursday, May 16th Online or in Dättwil - Switzerland to share your knowledge and challenges with peers and E&amp;L experts. As an attendee you will have the possibility to network, build useful relationships, and hear panel discussions.
<h4>Venues</h4>
Attend On-site at Waters AG | Täfernstrasse 14a | 5405 Dättwil | Switzerland
OR
Join us Online via Zoom
<h4>Registration information:</h4>
<ul>
<li>Online participation via Zoom - please register here: <a href="https://waters.zoom.us/webinar/register/1817098039303/WN_-kIHnJLqSoeTIMiO-rgmRA">Zoom event</a>
</li>
<li>On-site participation - Contact us via email for participation in Dättwil - Seats are limited! To register please contact <a href="Laura_Venezia@waters.com">Laura_Venezia@waters.com</a> and specify your first name, last name, company, email, phone and country
</li>
</ul>
<h4>This years TOPICS:</h4>
<ul>
<li>Latest developments in analytical instrumentation solutions.</li>
<li>Analytical consequences for recyclers and food packaging producers of the EU Regulation 2022/1616 on recycled plastic materials and articles intended to come into contact with foods, Deadline 15. Sept 2024</li>
<li>PFAS as a NIAS – the analytical challenges</li>
<li>Panel discussion with Q &amp; A</li>
<li>Sharing knowledge and challenges with peers and E&amp;L experts</li>
<li>... and more</li>
</ul>
<h4>Preliminary Agenda</h4>
<h5>08:30 - 09:00 | For attendees in Baden-Dättwil - Welcome Coffee/Tea/Gipfeli</h5>
<h5>09:00 - 09:15 | Welcome and Introduction to the workshop - Jürgen Marquardt, BASF Schweiz AG &amp; Jens Jacobsen, Waters Schweiz AG</h5>
<h5>09:15 – 09:45 | Regulatory aspects - Dr Nadine Bohni, Head of Department, Kantonales Labor Zürich, Switzerland</h5>
<h5>09:45 - 10:15 | Latest developments - Prof Dr. Cristina Nerin, Dept of Analytical Chemistry &amp; Director of GUIA, University of Zaragoza, Spain</h5>
<h5>10:15 - 10:45 | Coffee Break</h5>
<h5>10:45 - 11:15 | Merck’s Input on E&amp;L/FCM - Dr Markus Obkircher, Director R&amp;D, Merck India, Bengaluru, India</h5>
<h5>11:15 - 11:45 | News from the Intertek Lab - Dr. J. Susanne Becker, Intertek AG, Switzerland</h5>
<h5>11:45 - 12:15 | Latest Applications in the field of E&amp;L - Dr. Rachel Sanig, Waters Corporation</h5>
<h5>12:15 - 12:30 | Panel discussion &amp; Closing - All</h5>
<h5>12.30 | End of the online workshop &amp; Lunch for attendees in Dättwil</h5>
<h4>Please note that:</h4>
<ul>
<li>The Workshop is free of charge and will be delivered in English
</li>
<li>Registration Deadline for in-person participation is April 30th 2024
</li>
<li>The number of seats is limited to 15 for the in-person participation at Waters AG (Dättwil)
</li>
</ul>
We are looking forward to welcoming you!
Jens Jacobsen, Waters Schweiz AG
Jürgen Marquardt, BASF Schweiz AG

Waters: 7th Swiss Workshop on Extractables and Leachables

7th Swiss Workshop on Extractables and Leachables

Join 7th Swiss Networking Workshop on migration of chemicals and potentially harmful substances from packaging materials.

<h3>MS School – Fundamentals of Mass Spectrometry Part 3</h3>
Mass spectrometry is a powerful analytical technique that provides valuable information about the composition and structure of molecules. Understanding the fundamentals will empower you to make informed decisions about adding mass spectrometry to your laboratory analyses or maximizing the potential of your current MS systems.
In this educational webinar series, each session will cover a different aspect of mass spectrometry:
Part Three: Coupling mass spectrometry to liquid chromatography:
This session will outline the factors which impact LC/MS methods, such as solvents and additives. The use of multiple detectors will also be discussed and the session will end with some “care and feeding” information for MS systems.
<blockquote>
Presenter: Kieron Faherty, Ph.D. (Separations and Mass Spectrometry Field Marketing Manager, Waters Corporation)
</blockquote>
<blockquote>
Kieron Faherty is the Separations and Mass Spectrometry Field Marketing Manager for the Americas at Waters Corporation. He received his B.Sc. (Hons) in Chemistry from the University of Reading (Reading, Berkshire, UK) and his doctorate in Chemistry from the University of Massachusetts (Amherst, MA). He has held several field-based positions during his twenty-plus years at Waters, from Field Service Engineer on both quadrupole and Time-of-Flight MS systems to Principal Field Applications Specialist focused on biopharmaceutical applications.
</blockquote>

Waters Corporation: MS School – Fundamentals of Mass Spectrometry Series

Coupling mass spectrometry to liquid chromatography

This session will outline the factors which impact LC/MS methods, such as solvents and additives.

By attending this presentation, you will learn about:
<ul>
<li>The strategies for analyzing broad panels of pesticides with both LC/MS/MS and GC/MS/MS
</li>
<li>The approaches to address matrix interferences and consideration for instruments and methodologies
</li>
<li>Method validation requirements and accreditation criteria from the government perspective
</li>
</ul>
This presentation will review the laboratory perspective on the regulation and surveillance of approximately 270 pesticides and how this testing ties into federal government programs. Resulting methods used by the Ohio Department of Agriculture (ODA) Pesticide Residue laboratory show a lower quantitation limit at or below 10 parts per billion in complex matrices using a QuEChERS extraction paired with GC/MS/MS and LC/MS/MS. This work will summarize data found using these methods and compare goals, analysis requirements, and challenges between the USDA Agriculture Monitoring Service Pesticide Data Program and the U.S. EPA Region 5 with respect to pesticide use.
Additionally discussed will be strategies and challenges of using multiresidue methods on mass spectrometry platforms from the ODA including:
<ul>
<li>Workflow strategies
</li>
<li>Matrix interferences and cleanup
</li>
<li>Instrumental and methodological considerations, including compatibility of pesticides in these methods
</li>
<li>Method validation requirements and accreditation criteria
</li>
</ul>
<blockquote>
Presenter: Deidre E. Damon (Scientist and Mass Spectrometrist, Ohio Department of Agriculture’s Consumer Protection Laboratory)
</blockquote>
<blockquote>
Deidre Damon has been a scientist and mass spectrometrist for the Ohio Department of Agriculture’s Consumer Protection laboratory since 2019. She earned her PhD in analytical chemistry at the Ohio State University, focusing on alternative sampling and ionization sources for mass spectrometry. Since 2021, she has supervised the Pesticide Residue and Industrial Hemp laboratories where she oversees regulatory and surveillance testing of pesticides in environmental and food commodities on behalf of the U.S. EPA, USDA, and FDA for the state of Ohio.
</blockquote>

Separation Science - A Government Perspective on Pesticide Surveillance and Enforcement in Food and the Environment

A Government Perspective on Pesticide Surveillance and Enforcement in Food and the Environment

Learn about the strategies for analyzing broad panels of pesticides with both LC/MS/MS and GC/MS/MS

A Government Perspective on Pesticide Surveillance

Join us for an insightful webinar delving into the complexities surrounding nitrosamines in pharmaceutical products. Nitrosamines - known carcinogens, have emerged as a critical concern in the pharmaceutical industry, triggering stringent regulatory scrutiny. This webinar will explore the compendial standards, regulatory landscape, and analytical hurdles associated with detecting and mitigating nitrosamine contamination.
Gain invaluable insights from experts as we navigate the multifaceted challenges and discuss practical strategies for compliance and risk management.
Key Learnings:
<ul>
<li>Best practices for conducting risk assessment and testing for nitrosamine impurities
</li>
<li>How to assess the risk associated with Nitrosamines and developing control strategies
</li>
<li>Workflow for 17 Nitrosamines covering Sample Prep and LC-MS/MS method
</li>
<li>Control strategies aimed at addressing sensitivity, selectivity, and reproducibility issues with particular emphasis on sample preparation challenges
</li>
</ul>
<blockquote>
Presenter: Dr. Amanda Guiraldelli, Ph.D (Scientific Affairs Manager, United States Pharmacopeia)
</blockquote>
<blockquote>
Amanda Guiraldelli has been with USP since 2012 and holds the position of scientific affairs manager. She also serves as scientific liaison for the USP Measurement and Data Quality Expert Committee, where she works to develop and revise USP standards related to analytical procedure lifecycle/validation. Previously, Amanda worked as senior scientist at the USP reference standard laboratory for 8 years with characterization of compendial standards. She is visiting professor at the Institute of Chemistry at the University of Campinas (UNICAMP) in Brazil and is a frequent speaker and instructor on topics related to analytical procedure life cycle, AQbD and Chromatography.
</blockquote>
<blockquote>
Amanda is specialist in mass spectrometry, chromatography, omics and chemometrics and has more than 15 years of experience in pharmaceutical R&amp;D areas. Prior to joining USP, she was R&amp;D scientist in a Brazilian pharmaceutical industry and visiting scientist at TU Berlin in Germany and Leiden University in Netherlands (Center for Proteomics and Metabolomics) working on proteins characterization by LC-HRMS and procedure development using UHPLC-HRMS. Amanda is graduated in pharmacy biochemistry and holds a Ph.D. in analytical chemistry from the FCFRP - University of São Paulo (metabolomics by UHPLC-HRMS, GC-MS and 1H NMR and chemometrics).
</blockquote>
<blockquote>
Presenter: Mr. Naiffer Romero (MSc, MPH, United States Pharmacopeia)
</blockquote>
<blockquote>
Naiffer has more than 19+ years of pharmaceutical industry experience. In his 15 years with USP, he has served several roles: lead scientist in performance testing compendial reference standards development, Manager in charge of LATAM Compendial engagement and education with stakeholders and national regulatory bodies, and certified USP Education instructor.
</blockquote>
<blockquote>
Naiffer joined USP’s Scientific Affair performance cell in 2020, where he leads scientific outreach and technical engagement for LATAM &amp; US region on critical national health priority topics. His combined pharmaceutical expertise includes Analytical development, salt and polymorph selection, Development of dissolution methods, IVIVC modeling, and impurity analytical strategy. Naiffer is a recognized subject matter expert in Nitrosamines Impurities, and he also serves as a member of USP’s Nitrosamine workstream Committee and community manager to ‘Nitrosamine Exchange’, a knowledge community hosted by USP in All-things Nitrosamines Impurities.
</blockquote>
<blockquote>
Naiffer also liaises technical discussions on pharmacopeial collaboration, including the International Meeting of World Pharmacopeias (part of WHO), international compendial discussion groups, and several regional regulatory agencies’ nitrosamines working groups.
</blockquote>
<blockquote>
Presenter: Mr. Tobias Weimer (Produktspezialist LC &amp; LC/MSD, Agilent Technologies) 
</blockquote>
<blockquote>
Tobias hat in Marburg an der Philipps Universität Chemie studiert Seine Leidenschaft für die analytische Chemie und Chromatographie wurde bereits in der Oberschule geweckt und im Studium vertieft mit einer gezielten Ausrichtung auf analytische Trenntechniken. Über die Flüssigkeitschromatographie im Bereich LC Säulen führte Ihn sein Weg zu LC Systemen.
</blockquote>

Agilent: Unraveling Nitrosamines: Navigating Compendial, Regulatory, and Analytical Challenges

Unraveling Nitrosamines: Navigating Compendial, Regulatory, and Analytical Challenges

Webinar will explore the compendial standards, regulatory landscape, and analytical hurdles associated with detecting and mitigating nitrosamine contamination.

Unraveling Nitrosamines: Navigating Compendial, Regulatory

Human blood plasma contains thousands of distinct lipid species. These lipids can provide new insights into health and disease, with lipidomic profiling revealing new biomarkers for various conditions and being used to monitor the efficacy of treatments.
This webinar explores a new workflow for lipidomics using dia-PASEF – a mass spectrometry approach that allows for faster, more comprehensive analysis. Our expert speaker will show how this method increases lipid library coverage by 60% and allows you to capture complete lipid data in a single run. They will also unveil the optimal approach for high-throughput lipid analysis in human plasma, helping you to enhance your lipidomics research. 
Attend this webinar to:
<ul>
<li>Increase your lipid library coverage with dia-PASEF</li>
<li>Hear how to gain complete lipid data in a single run</li>
<li>Discover an optimized analysis scheme for high-throughput lipidomics</li>
</ul>
<blockquote>
Presenter: Dr. Hannes Röst (Assistant Professor and Canada Research Chair in Mass Spectrometry-Based Personalized Medicine at University of Toronto)
</blockquote>
<blockquote>
I am a bioinformatics researcher interested in high-throughput technologies that allow us to study the molecular phenotype of a biological system comprehensively. I have worked on theoretical questions in targeted proteomics, contributed to the development of SWATH-MS and wrote the first software capable of targeted analysis of SWATH-MS data in high throughput. I studied at ETH Zurich, Switzerland, worked with Ruedi Aebersold during my PhD and I am now working with Mike Snyder at Stanford University to apply mass spectrometry in a personalized medicine context.
</blockquote>

Technology Networks: Next-Generation Plasma Lipidomics: Quantification With dia-PASEF

Next-Generation Plasma Lipidomics: Quantification With dia-PASEF

New workflow for lipidomics using dia-PASEF – a mass spectrometry approach that allows for faster, more comprehensive analysis.

Plasma Lipidomics: Quantification With dia-PASEF

<h4>LC-MS/MS fundamentals webinar series 2.0</h4>
Advanced techniques for data acquisition and processing
Elevate your analytical expertise with advanced techniques and workflows
Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series. Based on our LC-MS/MS 1.0 webinar series, these sessions will go beyond the fundamentals of LC-MS/MS and introduce ways to advance your analytical methods and data processing workflows.
Every other week, we will explore how to optimize SCIEX OS software with short, 30-minute expert-led presentations.
<h4>This webinar:</h4>
May 7, 2024 11:00 a.m. - 11:30 a.m. CET - Beyond the fundamentals
<h4>Other webinars from the series:</h4>
May 21, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3852">Advanced MS/MS method building</a>
Gain insight into advanced features for maximizing sensitivity in your mass spectrometry analyses.
June 4, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3853">Mastering chromatography</a>
Discover how to optimize your chromatography for even the most challenging compounds while creating and building LC methods.
June 18, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3854">It&#39;s a TRAP! Getting the most out of your QTRAP system</a>
Learn when to utilize QTRAP functionality to create more selective and sensitive methods.
July 2, 2024 11:00 a.m. - 11:30 a.m. CET- <a href="https://lcms.labrulez.com/webinar/3855">Troubleshooting at the source</a>
Acquire the knowledge needed to optimize source parameters and identify and resolve ionization-related problems.
July 16, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3856">Automating data processing</a>
Learn how to automate your data processing with custom flagging and rules for efficient data review in SCIEX OS software.
July 30, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3857">Excel strategies for mass spectrometry data analysis</a>
Take an in-depth look at when and how to use Excel to increase your productivity.

SCIEX: LC-MS/MS fundamentals webinar series 2.0

Beyond the fundamentals

Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series.

Beyond the LC-MS/MS fundamentals

Recognizing the importance of cellular metabolism and the complexity of cell-cell heterogeneity, SpaceM has emerged as a promising technology with high potential for investigating single-cell metabolomics. SpaceM is expected to grant broad access to single-cell metabolomics, enabling investigations across diverse cellular models. Additionally, addressing the challenge of reproducibility, we present HT-SpaceM, a high-throughput method showcasing robust reproducibility in identifying metabolites in 10 cell lines, highlighting the promise of the SpaceM method in understanding cellular metabolism and disease.
<blockquote>
Presenter: Shawn Owens, Ph.D. (Imaging Mass Spectrometrist, SpaceM, BioInnovation Institute, Copenhagen, Denmark)
</blockquote>
<blockquote>
Shawn began his mass spectrometry imaging journey over 10 years ago, at the University of California- Santa Barbara- where he earned his PhD. With his degree in hand, he began a journey that led him through roles in industry- first at Bruker for nearly 5 years, followed by a year at BASF in New York. Eager to explore new horizons, Shawn embarked on a transformative journey in a startup, joining SpaceM in Copenhagen, Denmark- where he assumed the role of R&amp;D Team Leader and Mass Spectrometrist, a role he has held for the past 18 months.
</blockquote>

Bruker: High Throughput Single-Cell Metabolomics

High Throughput Single-Cell Metabolomics

We present HT-SpaceM, a high-throughput method showcasing robust reproducibility in identifying metabolites in 10 cell lines.

Protein ubiquitination is a versatile post-translational modification that orchestrates many cellular pathways. Ubiquitin ligases are key specificity factors in this system. The HECT-type ubiquitin ligase HACE1 controls membrane dynamics and redox homeostasis by mechanisms that are still poorly understood at a structural level.
We determined the cryo-EM structures of HACE1 alone and in complex with its physiological substrate, RAC1. Together with biophysical analyses including HDX-MS and mass photometry, our studies reveal how HACE1 is regulated and how it recognizes its substrate with specificity. I am going to provide an overview of this work with a specific focus on the use of mass photometry.
All participants in this webinar will receive a Certificate of Attendance.
<blockquote>
Presenter: Sonja Lorenz (Research Group Leader, Max Planck Institute for Multidisciplinary Sciences)
</blockquote>

Wiley: Mass photometry to study the oligomerization of HACE1

Mass photometry to study the oligomerization of HACE1

Studies reveal how HACE1 is regulated and how it recognizes its substrate with specificity.

<h3>PFAS and us: The science</h3>
Driving change for a healthier world
Webinar series
<h4>Enrich your understanding of PFAS chemicals and their impact</h4>
Stay on the leading edge of all things PFAS with this enlightening monthly webinar series on testing workflows and cutting-edge technology that will demystify these “forever chemicals”.
Each month, in these 30-minute sessions, industry thought leaders unite to share the current state of PFAS testing and the far-reaching impact that PFAS have on human health and the environment. Build on your current knowledge of testing methodologies and research techniques that will help you develop your own innovative strategies for precise identification and quantitation. Make a lasting impact and join us for these conversations.
<h4>This Webinar:</h4>
May 8, 2024 10:00 a.m. PT/ 1:00 p.m. ET - Rapid PFAS testing with no compromises: direct-inject analysis
<blockquote>
Presenter: Jamie Fox (PFAS Technical Program Manager, Enthalpy Analytical)
</blockquote>
<h4>Other Webinars from the Series:</h4>
April 10, 2024 10:00 a.m. PT/ 1:00 p.m. ET - <a href="https://lcms.labrulez.com/webinar/3865">Examining the exogenous: PFAS and beyond</a>
<blockquote>
Presenter: Andrew Patterson (Vice President, Innovation and Development, Eurofins Environmental Testing America)
</blockquote>
June 12, 2024 10:00 a.m. PT/ 1:00 p.m. ET - <a href="https://lcms.labrulez.com/webinar/3867">Assessment of advanced analytical instruments to reach required limits of quantitation for PFAS in foods</a>
<blockquote>
Presenter: Susan Genualdi, PhD (Research Chemist, FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science)
</blockquote>
July 17, 2024 10:00 a.m. PT/ 1:00 p.m. ET - <a href="https://lcms.labrulez.com/webinar/3868">Detecting and identifying known and novel per/polyfluoroalkyl substances (PFAS) in a marine apex predator</a>
<blockquote>
Presenter: Carrie McDonough (Assistant Professor, Chemistry, Carnegie Mellon University)
</blockquote>
August 14, 2024 10:00 a.m. PT/ 1:00 p.m. ET - <a href="https://lcms.labrulez.com/webinar/3869">Whole blood microsampling methods for PFAS exposure biomonitoring</a>
<blockquote>
Presenter: Andrew J. Morris, PhD (Professor, University of Arkansas for Medical Sciences, Research Career Scientist, Central Arkansas Veterans Affairs Healthcare System)
</blockquote>
September 11, 2024 10:00 a.m. PT/ 1:00 p.m. ET - <a href="https://lcms.labrulez.com/webinar/3870">Analysis of ultra short-chain PFCAs to better understand environmental sources and fate</a>
<blockquote>
Presenter: Cora J. Young (Associate Professor, Department of Chemistry, York University)
</blockquote>

Rapid PFAS testing with no compromises: direct-inject analysis

Stay on the leading edge of all things PFAS with this enlightening monthly webinar series.

Rapid PFAS testing: direct-inject analysis

Advances in enzymatic digestion techniques combined with new software analysis tools that incorporate in silico digestion capabilities for mRNA sequences, demonstrate the potential for sequence mapping and confirmation of mRNA using high-resolution LCMS. These new advances have the potential to progress mRNA sequencing by LCMS into the same well-defined workflow currently in place for the peptide mapping of therapeutic proteins.
Dr. Ken Cook, senior European team leader for the biopharma/pharma expert support group at Thermo Fisher Scientific, and Keeley Murphy, software product manager at Thermo Fisher Scientifc, will discuss the use of an automated workflow which includes enzymatic digestion, high-resolution LCMS analysis, and data analysis for mRNA sequencing.
Key learning objectives
<ul>
<li>Discover a new automated workflow for mRNA sequencing by high-resolution LCMS</li>
<li>Learn how to implement routine sequence confirmation of mRNA using high-resolution LCMS</li>
<li>Explore new software analysis tools that incorporate in silico digestion capabilities for mRNA sequences</li>
</ul>
Who should attend?
<ul>
<li>Biopharmaceutical research scientists</li>
<li>Analytical scientists from biopharma companies working on or interested in mRNA based therapies</li>
<li>PhD students in any field of biotherapeutic drug development</li>
<li>Scientists looking to advance their knowledge of oligonucleotide and mRNA analysis</li>
</ul>
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
<blockquote>
Presenter: Dr. Ken Cook (Senior European team leader for the biopharma/pharma expert support group, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Presenter: Keeley Murphy (Software product manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Moderator: Moderator: Dora Wells (Editoral Team, SelectScience)
</blockquote>

SelectScience: Automated Workflow for mRNA Sequencing by High-Resolution LCMS

Automated Workflow for mRNA Sequencing by High-Resolution LCMS

We will discuss the use of an automated workflow which includes enzymatic digestion, high-resolution LCMS analysis, and data analysis for mRNA sequencing.

LCMS webinars focusing on LC/MS - page 56