Tasty beer starts with knowing what’s in your hops. Explore how online SPE makes bitter acid analysis in hops faster and more reliable.<h4>How can you detect bitter acid profiles quickly, reliably, and more sustainably?</h4>For craft brewers and beer lovers alike, a refreshing experience is all about flavor.So how can you achieve the desired bitterness in your beer? The answer is not just about the recipe. Finding the right flavor profile starts with the bitter acids present in the starting hops material.<div><div>Hops (the heart of your favorite beer) are the source of the brew’s distinctive flavor tied to bitterness and aroma.At the molecular level, bitterness is driven by <a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0308814622016338">α- and β-bitter acids</a>, like humulones and lupulones, whose concentrations determine the final sensory profile of the beer (Figure 1).Accurately characterizing these compounds in each batch allows brewers to unlock the full potential of every variety of hops.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 1. General chemical structure of hop bitter acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg 222w," sizes="100vw" width="700" height="493">While conventional analytical methods rely on long, manual sample preparation steps and hazardous solvents, laboratories now strive for greener and more efficient workflows.And moving from manual to online sample preparation is one of the easiest ways your lab can reduce waste and — most importantly — improve reliability with automation.<h4>Key takeaways</h4><ul><li>Online SPE reduces hands-on work, shortens turnaround time, and supports more sustainable methods by cutting solvent use and eliminating single-use cartridges.</li><li>Automated UHPLC workflows are easier for new users to execute, offering more reproducible quantifications of α- and β-bitter acids in hops.</li><li>Accurate bitter acid profiles help brewers distinguish hop varieties and control flavor with confidence.</li></ul><h4>Comparing offline vs. online solid phase extraction for bitter acid HPLC analysis</h4>If you’ve spent long hours in the lab preparing samples for hops analysis, you’re not alone.Manual sample preparation often takes the most time in hops analysis, an area where online <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/chromatography-learning-center/chromatography-consumables/sample-prep.html">solid phase extraction</a> (SPE) can make a real difference. Here’s why.Manual SPE has a lot of manual steps. Extraction. Cartridge loading. Washing. Elution. And sometimes solvent exchange or reduction. All before your actual analysis begins. This labor-intensive workflow can take up to an hour and depends strongly on operator skillsets, making reproducibility a challenge for new hires.<h4>Online SPE analysis provides key benefits like:</h4><ul><li>Hands-off workflow free of cartridges, manifolds, or vacuum steps.</li><li>Column washing and re-equilibration occur in parallel with separation.</li><li>SPE step is complete in just two minutes.</li><li>Minimizes operator-dependent variability.</li><li>Uses less than 8 mL of solvent.</li></ul>Let’s explore what this technique looks like in practice.<h4>Online SPE for analyzing α- and β-bitter acids in hops standard solutions.</h4>Changing your sample preparation from manual to automated isn’t complicated. With the right tools you can fully integrate online SPE with your UHPLC system (Figure 2).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 2. Schematic workflow for the determination of bitter acids in hops. The process involves clean up and instrumental analysis using the Thermo Scientific Vanquish Online SPE UHPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg 245w," sizes="100vw" width="700" height="323"><h4>The process for analyzing a hops standard solution is straightforward:</h4><ol><li>First, extract hop samples with ethanol (a greener alternative to toluene or diethyl ether in conventional methods).</li><li>Inject the extract directly into your instrument for analysis. Bitter acids retain<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1970"> on the SPE column</a> while matrix interferences that can comprise quantitation are removed.</li><li>Next, backflush the SPE column to transfer the analytes to the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/423"> analytical column </a>for separation. While this separation is taking place, the SPE column is washed and re-equilibrated in parallel, keeping the total run time to 15 minutes, with the separation of all six major bitter acids in a single analysis (Figure 3).</li></ol><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 3. UV chromatogram of hop bitter acids in standard solution (1-cohumulone, 2-humulone, 3-adhumulone, 4-colupulone, 5-lupulone, 6-adlupulone)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg 245w," sizes="100vw" width="700" height="347"><h4>Online SPE for analyzing α- and β-bitter acids in real hops samples</h4>Analytical labs need methods that are accurate and reliable for brewers to develop distinct and reproducible flavor profiles across batches.To assess the applicability of online SPE UHPLC methods for hops analysis, we analyzed bitter acid profiles from four species — Sultana, Barbe Rouge, Azacca, and Sabro.The concentration of α-acids dominated all samples, while each hops species exhibited distinct profiles in terms of α-acid and β-acid content, making them suitable for different brewing strategies (Figure 4).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 4. Bitter acid profiles in four different hop species, error bars display SD (n=6). To check method consistency, we measured each hops extract six times. Variation between measurements was low, with relative standard deviation below 3.5 % across all hops species." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg 245w," sizes="100vw" width="700" height="410"><ul><li>For testing labs, this process translates into a workflow that is easy to run, fast, and delivers reliable results without added complexity.</li><li>For craft brewers, reliability means clear, trustworthy insights into hops bitter acid profiles, for better hop selection and more precise control of bitterness and flavor in your beer.</li></ul><h4>From carefully procured samples to tasty sips</h4>Efficient UHPLC workflows support faster results, less solvent use, and reliable bitterness data for brewers. And online SPE turns those advantages into practical, day-to-day benefits for brewers and labs alike.<ul><li>Less hands-on skills required for lab analysts</li><li>Faster results from labs to brewers</li><li>A more sustainable way to work</li><li>Clear insights into hops flavor</li></ul>To learn more about the method and see the full application data, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cn_004238_hplc_vanquish_online_spe_bitter_acids_hops_cn004238_na_en_587a5d300b.pdf">check out our application note today</a>.<h4>FAQs</h4><div><div><h5>What are the key compounds in hops analyzed by HPLC?</h5>Bitter acids, namely α-acids and β-acids, especially the six major bitter acids (humulones and lupulones) that define hop bitterness and are required for quality control and brewing decisions.</div><div><h5>What column types are recommended for hop acid separations?</h5>Classical C18 Silica columns are ideal for bitter acids separation. UHPLC compatible columns with particle size ≤ 2 µm boost analysis with higher flow rate, thus shorter analysis time and solvent consumption.</div><div><h5>What’s the best workflow for hops analysis?</h5>A typical workflow for hop analysis consists of three main steps: extraction of the target compounds, clean-up of co-extracted matrix components, and instrumental analysis by HPLC or UHPLC. To keep this workflow efficient and reproducible, you should minimize manual handling and add in automation when possible. Integrating online SPE into your LC instrument allows sample clean-up to run automatically, reducing hands-on time, solvent use, and variability while delivering faster, more reliable results.</div></div><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#UHPLC #Automation</blockquote></div></div>

How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors

In the week of June 29, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Insights from an IC specialist: To be suppressed or not suppressed?</h5><ul><li>Tu, 30.6.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6310">Registration</a></li></ul>Join Thermo Fisher’s Ask the Experts session to learn how suppressor technology impacts ion chromatography performance, sensitivity, reliability, maintenance, and troubleshooting.<h5>2. SCIEX: Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery</h5><ul><li>Tu, 30.6.2026 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6311">Registration</a></li></ul>Discover how ZenoTOF high-resolution mass spectrometry is accelerating single-cell proteomics and plasma biomarker discovery through enhanced sensitivity, throughput, and automation.<h5>3. Agilent Technologies: Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres</h5><ul><li>Tu, 30.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6052">Registration</a></li></ul>This webinar will discuss diffuse transmission and reflection UV/VIS measurements, including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer.<h5>4. Waters Corporation: Informatics series #33 Tips, Tricks and Best Practices</h5><ul><li>Th, 2.7.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6315">Registration</a></li></ul>This interactive session revisits essential features, shortcuts, and practical techniques in Empower software that can streamline everyday laboratory work and reduce unnecessary effort.<h5>5. Waters Corporation: Unlocking Therapeutic Peptide Characterisation (GLP-1RAs) with Cyclic IMS</h5><ul><li>Th, 2.7.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6313">Registration</a></li></ul>Discover how cyclic ion mobility spectrometry (cyclic IMS) improves characterization of GLP-1 analogues and therapeutic peptides, supporting development, quality control, and regulatory submissions.<h5>6. Agilent Technologies: Spectral Flow Cytometry Masterclass - Session 1</h5><ul><li>Fr, 3.7.2026 07:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6316">Registration</a></li></ul>Learn how full-spectrum flow cytometry enables high-dimensional cell analysis. Explore spectral flow technology, experimental design, and applications in immunology, oncology, and vaccine research.

Webinars LabRulezLCMS Week 27/2026

The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607">A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;<h4>Evaluation of measurement procedure performance&nbsp;</h4>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;<ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"><h4>Characterisation of candidate reference materials&nbsp;</h4>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;<ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4>Other ILCs&nbsp;</h4>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).

Interlaboratory comparisons other than proficiency testing

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The Analytical Scientist

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Shimadzu Corporation

Welcome to The Analytical Scientist’s Trends and Challenges in PFAS Analysis forum!
Per- and poly-fluorinated alkyl substances, or PFAS, are a family of synthetic substances used in everyday products, such as stain and grease-repellent coatings and have appeared in almost all foods and drinking water. Toxic at extremely low levels, regulators demand low detection limits, and the list of PFAS compounds under investigation continues to expand. 
We recently asked our readers for their thoughts on the challenges involved in PFAS analysis, whether current methods are up to the task, and what analytical advances may be on the horizon. 
Here, our panel of experts will discuss the survey findings and share their perspectives on the latest trends and best practices in PFAS analysis. 
The event will have three parts: 
<ul>
<li>Part I: A discussion of the results of our recent vendor-neutral audience survey (10-15 minutes).
</li>
<li>Part II: Technology/application-focused presentations from each of our speakers (15 minutes each).
</li>
<li>Part III: A chance for you to ask our speakers questions as part of an audience Q&amp;A (15 minutes).
</li>
</ul>
<blockquote>
Presenter: Day Powell (Environmental Application Specialist , Agilent)
</blockquote>
<blockquote>
Day has worked for Agilent as an Environmental Specialist for one year. Before this he worked for a major UK Water company (United Utilities) as a senior analyst responsible for developing new methodologies for both LC/MS and GC/MS applications.
</blockquote>
<blockquote>
Day has analysed PFAS for several years and helped United Utilities to gain UKAS accreditation for determining 47 PFAS by LC/MS in drinking water using direct injection to address the latest Drinking Water Inspectorate (DWI).
</blockquote>
<blockquote>
Presenter: Marcus Chadha (EMEA Applications Specialist Manager, Agilent) Dr. Marcus Chadha has worked for Agilent for seven years where he first worked as an LC/MS Field Application Specialist before moving on to being the EMEA Applications Specialist Manager in 2021.
</blockquote>
<blockquote>
In his roles he has collaborated with our Environmental and Food customers, developed new methods, and trained LC/TQ and LC-Q/TOF MS workflows to new and existing customers.
</blockquote>
<blockquote>
He now coordinates these activities using his team of GC/MS and LC/MS application specialists. Marcus is also responsible for the market specialisation activities for the environmental market across Europe.
</blockquote>
<blockquote>
Presenter: Linx Waclaski (Product Manager for Ion Chromatography, Metrohm USA)
</blockquote>
<blockquote>
Linx Waclaski is the Product Manager for Ion Chromatography at Metrohm USA, in Riverview, Florida. He has years of experience in multiple chromatographic techniques, including ion chromatography, gas chromatography, liquid chromatography, and mass spectrometry, with extensive experience in R&amp;D and applications development.
</blockquote>
<blockquote>
His chromatography applications experience extends across environmental, food safety, and life sciences industries. He has an M.S. in Forensic Science from Duquesne University.
</blockquote>
<blockquote>
Presenter: Ruth Marfil-Vega (Senior Market Manager - Environmental, Shimadzu)
</blockquote>
<blockquote>
Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants.
</blockquote>
<blockquote>
Since Ruth joined Shimadzu five years ago, she has continued to work with environmental stakeholders to ensure that analytical instrumentation and workflows support their success.
</blockquote>
<blockquote>
She earned a BSc in Chemistry from the University of Valladolid (Spain) and a PhD in Environmental Science and Engineering from the University of Cincinnati.
</blockquote>

Agilent Technologies: Trends and Challenges in PFAS Analysis

Trends and Challenges in PFAS Analysis

Survey findings and perspectives on the latest trends and best practices in PFAS analysis.

Ultrapure water (UPW) is crucial for the production of superior-quality semiconductors, but ensuring final product quality can be a challenge without the right tools.
UPW undergoes extensive and costly purification, utilizing various physical and chemical treatments to meet increasingly rigorous purity standards. In the face of global water shortages, efficient UPW production is essential. Water recycling facilities at semiconductor plants are tasked with addressing this concern, regenerating wastewater back into UPW. However, the integrity of regenerated UPW must be verified to ensure final product quality. This is where online ion chromatography provides a novel advantage: detecting trace anions, cations, and silica contaminants in real-time down to parts-per-trillion levels. 
Join us for a conversation with two industry experts: Ben Greenwood, Senior Manager at Micron Technology&#39;s Chemistry Lab, and Dariana Martinez, Product Application Specialist at Metrohm USA. Together, they will delve into the pressing water challenges currently faced by the semiconductor industry. Additionally, they will shed light on the pivotal role of ultrapure water and the significance of real-time ion chromatography to ensure quality control. 
Key Learning Objectives:
<ul>
<li>Understand the pivotal role of ultrapure water (UPW) in semiconductor manufacturing and its direct impact on product quality and performance. 
</li>
<li>Gain insights into the scale of water consumption in the semiconductor industry and the pressing challenges faced in meeting increasingly rigorous purity standards. 
</li>
<li>Discuss the advanced analytical capabilities of online ion chromatography, and learn how it accurately measures anions, cations, and silica contaminants to verify UPW purity.
</li>
</ul>
Who Should Attend:
<ul>
<li>Anyone interested in leveraging automation for process optimization and near-real-time data analytics
</li>
<li>Process engineers and plant operators responsible for analytical testing and QA/QC Managers responsible for ensuring maximum product quality
</li>
<li>Those involved in adopting or implementing Industry 4.0 initiatives and/or focused on developing newer, more efficient manufacturing processes
</li>
</ul>
<blockquote>
Presenter: Ben Greenwood (Senior Manager, Micron Technology&#39;s Chemistry Lab)
</blockquote>
<blockquote>
Presenter: Dariana Martinez (Product Application Specialist, Metrohm USA)
</blockquote>
<blockquote>
Presenter: Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)
</blockquote>

C&EN: Mastering UPW Quality with Real-Time Trace Ion Detection

Mastering UPW Quality with Real-Time Trace Ion Detection

The pressing water challenges currently faced by the semiconductor industry.

<h4>Overview</h4>
Ion chromatography, a crucial method for separating and quantifying ionic components, faces complexities in diverse sample matrices. To meet stringent analysis standards and ensure IC component longevity, sample pretreatment is essential. Samples with elevated particulate loads, extreme pH, colloids or high cation concentrations jeopardize chromatographic integrity, potentially reducing column lifespan. Considerations extend to IC-incompatible matrices, like those involving organic solvents, and scenarios requiring ultra trace analyses with preconcentration.
While manual methods exist, the revolutionary shift to inline automation for sample preparation promises increased efficiency, throughput, prolonged column lifespan and notable enhancements in data accuracy and reproducibility. Join our upcoming webinar for an insightful exploration led by Sylvia Singh, Ion Chromatography Applications Specialist at Metrohm USA, who will unravel the intricacies and significant benefits of inline sample preparation for analytical processes. 
Key Learning Objectives:
<ul>
<li>Learn about the benefits of inline sample preparation for ion chromatography
</li>
<li>Discover the types Metrohm inline sample preparation that are available
</li>
<li>Gain an understanding of applications that benefit from inline automation
</li>
<li>Learn how to choose the best inline sample prep technique for your sample type and laboratory need
</li>
</ul>
Who Should Attend:
<ul>
<li>Analysts, technicians, chemists who are either currently using or plan to use IC
</li>
<li>Lab managers considering automation for their current IC
</li>
<li>Students and researchers who may use IC
</li>
</ul>
<blockquote>
Presenter: Dr. Sylvia Singh (Applications Specialist for Ion Chromatography, Metrohm USA)
</blockquote>
<blockquote>
Presenter: Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)
</blockquote>

C&EN - Mastering Tricks for Improving Chromatography in Difficult Samples

Mastering Tricks for Improving Chromatography in Difficult Samples

Tricks for Improving Chromatography in Difficult Samples

Join us and our partners as we co-host a webinar presenting the latest news about ion chromatography (IC) applied to anions analysis in water samples and learn how to:
<ul>
<li>New technology is used for the analysis of older contaminants, such as nitrate, nitrite, and other anions.
</li>
<li>Improve performance of methods EPA 300/300.1.
</li>
<li>Increase your productivity with Shimadzu’s trusted and durable hardware.
</li>
</ul>
We will host a Q&amp;A session after the presentation to address any questions or comments.
<blockquote>
Presenter: Ruth Marfil-Vega, PhD (Sr Market Manager – Environmental, Shimadzu Scientific Instruments)
Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants. Since Ruth joined Shimadzu five years ago, she has continued to work with environmental stakeholders to ensure that analytical instrumentation and workflows support their success. She earned a BSc in Chemistry from the University of Valladolid (Spain) and a PhD in Environmental Science and Engineering from the University of Cincinnati.
</blockquote>
<blockquote>
Presenter: Nivesh Mittal (HPLC Product Manager, Shimadzu Scientific Instruments)
Dr. Nivesh Mittal has extensive experience in HPLC methods development and validation. Before joining Shimadzu in 2021, Nivesh was working in the pharmaceutical industry as a scientist, researching on the formulation development of nanoparticulate drug delivery systems for hard to manufacture compounds. Nivesh holds a BS and MS in Biotechnology from India, a PhD in Pharmaceutical Sciences from the University of Tennessee, and an MBA from the University of Memphis.
</blockquote>

Shimadzu Scientific Instruments: Ion Chromatography: A Break From the Tradition

Ion Chromatography: A Break From the Tradition

Join us and our partners as we co-host a webinar presenting the latest news about ion chromatography (IC) applied to anions analysis in water samples.

MagIC Net is the powerful software solution to control the ion chromatography instruments from Metrohm.
In this webinar you will learn about advanced functionalities to make your daily laboratory work more efficient such as the timer function, user-defined data monitoring, and the implementation of logical features in your IC method.
Participants in this webinar will also learn how to make their data handling more productive. Here, the relevant tools and features are advanced multi-parameter data search, control charts, and automatic database backup. A live Q&amp;A session will follow the webinar to address any questions you may have. 
<h4>Key learnings of this webinar:</h4>
<ul>
<li>Learning how to use the timer for automated start and stop options, how to implement a barcode reader, and how to set up user-defined monitoring parameters for system health checks as well as the validation of results and calibrations.
</li>
<li>Learning about logical decisions and how to implement them in your methods for inline dilution or automatic recalibration.
</li>
<li>Getting to know functions for advanced data handling and result management such as combining filters, customizing result overview, and minimizing manual steps for data backup.
</li>
<li>Learning how to personalize MagIC Net to adjust the software to your specific needs.
</li>
</ul>
Who should attend?
IC analysts, lab technicians, chemists, and everybody else currently using MagIC Net software.
<blockquote>
Presenter: Javier Espuelas, PhD (Product Specialist Ion Chromatography, Metrohm International Headquarters)
Javier Espuelas has been working for Metrohm for more than 20 years as Application Specialist developing analytcial methods and supporting customers in the field of ion chromatography. Before working for Metrohm, Javier obtained his PhD in chemistry from the Department of Analytical Chemistry of the University of Zaragoza in Spain, where he studied chromatography, electrochemistry, and spectroscopic analytical techniques.
</blockquote>
<blockquote>
Pesenter: Iris Reber (Sr. Product Specialist Ion Chromatography, Metrohm International Headquarters)
Iris is Senior Product Specialist at the Competence Center Ion Chromatography at Metrohm International Headquarters, Switzerland. She received her degree in chemistry from EPFL (Swiss Federal Institute of Technology, Lausanne).
Iris has worked for more than 12 years in the IC applications laboratory gaining extensive knowledge in this field.
</blockquote>

Metrohm: Showcasing advanced functionalities of MagIC Net

Showcasing advanced functionalities of MagIC Net

Showcasing advanced functionalities of MagIC Net software solution to control the ion chromatography instruments from Metrohm

Get ready to dive into the thrilling world of process analytics - game show style!
Join us for an engaging and educational event as you showcase your knowledge by answering questions to discover how process analyzers can be equipped with titration, ion chromatography or spectroscopy to solve even the toughest challenges.
Our hosts, Elena Hagemann, Product Manager for Process Spectroscopy, and Kraig Kmiotek, Product Manager for Process Wet Chemistry, will test your knowledge while introducing the FUNdamentals of process analytics and unraveling practical insights that can be applied in real-world situations.
Whether you&#39;re a seasoned expert or just curious about the basics, this interactive event promises to educate and entertain, combining the fun of a game show with the science and engineering of process analytics.
Register now, don’t miss out on the end-of-the-year fun!
<blockquote>
Presenter: Kraig Kmiotek (Product Manager for Process Wet Chemistry, Metrohm USA)
</blockquote>
<blockquote>
Kraig Kmiotek is the Product Manager for Process Wet Chemistry at Metrohm USA and has a Bachelor of Science in Chemistry from Purdue University. Since joining the Process Analytics team, his focus has been on application work, analyzer design and programming and customer and internal training of process analyzers. He is currently responsible for understanding customer requirements, driving product and service development, and strategic product marketing and demand generation.
</blockquote>
<blockquote>
Presenter: Elena Hagemann (Product Manager for Process Spectroscopy, Metrohm USA)
</blockquote>
<blockquote>
Elena Hagemann is the Product Manager for Process Spectroscopy at Metrohm USA in Riverview, Florida. She holds a master’s degree in Analytical and Bioanalytical Chemistry from the Applied University of Aalen, Germany, where her master thesis focused on Karl Fischer Titration, NIR Spectroscopy, and Multivariate Data Analysis. Elena joined the Metrohm Group in August 2013 and started with Metrohm USA in January 2018, focusing on Raman and NIR Spectroscopy.
</blockquote>

Metrohm: Process Analytics Showdown: Putting the Fun in Fundamentals

Process Analytics Showdown: Putting the Fun in Fundamentals

Not unlike your car, regular maintenance is essential to keeping your IC running at its best performance and preventing any major issues down the road. It’s critical to understand the typical “mileage” of the various parts of an IC system and to know when items need to be replaced or inspected.
In addition to performing regular maintenance, learning how to do basic troubleshooting can save you time and money, especially when dealing with minor issues that can be addressed in-house. Often times, a combination of carefully reading data and inspecting system components can lead to a simple solution to the problem.
In this webinar, Dr. Sylvia Singh, an Applications Specialist at Metrohm USA, will take us on a journey through the IC flow path, providing best practices for routine IC maintenance. She will also show you how to properly diagnose and troubleshoot some common issues you may come across with your instrumentation.
<blockquote>
Presenter: Sylvia Singh, PhD (Ion Chromatography Applications Specialist, Metrohm USA)
</blockquote>
<blockquote>
Dr. Sylvia Singh is the Applications Specialist for Ion Chromatography at Metrohm USA in Riverview, Florida. She earned her PhD in Chemistry with a focus on Bioorganic Chemistry at the University of South Florida (USF). At USF, Sylvia worked as a researcher and Teaching Assistant within the Chemistry Department. During her time with Metrohm USA, she continues to represent the voice of the customer while working on application growth through lab project feasibility studies, technical and applications support, as well as product support.
</blockquote>

Metrohm: Keep Your IC Running at Peak Performance Rerun

Keep Your IC Running at Peak Performance Rerun

This webinar will take us on a journey through the ion chromatography flow path, providing best practices for routine IC maintenance.

<h4>New innovation for daily excellence in ion chromatography: consistent results across operators and shifts!</h4>
Are you regularly performing ion chromatography tests? 
We&#39;ve listened to the feedback given by ion chromatography (IC) users and created a top-notch IC system to enable you to generate reliable and constant IC results – all day, every day, no matter who&#39;s running the tests. 
Detlef Jensen, our European senior expert on ion chromatography, will present our innovative new IC system designed to support laboratories in routinely generating dependable and consistent IC results. This new system will reduce IC training requirements and system downtime, and you can easily upgrade the system to meet ever-changing laboratory needs.
<h5>Why Should You Attend?</h5>
<ul>
<li>Get an in-depth look at our latest cutting-edge IC platform.</li>
<li>Learn how this IC platform can stretch costs further and give you flexibility for evolving business needs.</li>
<li>Discover how you can routinely acquire repeatable and reliable results.</li>
</ul>
<h5>This webinar is for scientists and laboratory professionals:</h5>
<ul>
<li>Working with water or wastewater analysis </li>
<li>Analysing APIs or impurities in pharmaceutical mixtures </li>
<li>Testing food samples for ionic substances</li>
</ul>
Join us on February 15th to explore the opportunities and advancements this IC system can bring to your laboratory. As a bonus, get tips on how to optimize your IC results, too. 
Can&#39;t attend the live broadcast? Np problem! Register anyway and you will automatically recive the link to the webinar recording.
<blockquote>
Presenter: Detlef Jensen (Sr. Application Expert Applied Markets, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Detlef holds a PhD in chemistry from the Technical University Berlin/Germany. For 30 years, he covered many positions at Dionex and Thermo Fisher Scientific. He is supporting our users and our team of field experts all over Europe with his deep knowledge of all aspects of ion chromatography and its applications.
</blockquote>

ThermoFisher Scientific: Ion chromatography innovation: New platform for routine IC applications

Ion chromatography innovation: New platform for routine IC applications

Innovative IC system designed to support laboratories in routinely generating dependable and consistent IC results will presented.

New platform for routine IC applications

Ion chromatography (IC) has become the preferred method for ion analysis, replacing many time-consuming and laborious wet-chemical techniques such as gravimetry, nephelometry, turbidimetry, etc. IC is a multi-parameter method and can be used for the determination of a wide array of anions, cations, transition metals, amines, carbohydrates, and organic acids.
In fact, the United States Pharmacopeia has modernized a substantial number of monographs to stipulate IC methods for numerous pharmaceutical assays of APIs as well as analysis of impurities and excipients. In a joint webinar on March 6, Dr. Raman, Director, Analys Lab, India, and Niranjan Kothandaraman, Product Manager Ion Chromatography at Metrohm India, will introduce you to applied ion chromatography. They present a number of applications to determine typical anions and cations, among them nitrite and nitrate, the precursors of nitrosamines. 
After their presentation, they will address any questions you may have in a Q&amp;A session at the end of the webinar. Register for this event now and get to know the potential of IC for your daily routine analytics!
Key learnings of this webinar:
<ul>
<li>Learning what ion chromatography is and how it can be used for identification and quantification of assay, impurities, and excipients</li>
<li>Understanding validated IC methods for pharmaceutical applications</li>
<li>Getting to know an IC method to determine nitrite and nitrate, the precursors of nitrosamines</li>
</ul>
Who should attend?
R&amp;D managers, QC managers, lab technicians and chemists responsible for R&amp;D and QC in research, development, and manufacturing of pharmaceuticals.
<blockquote>
Presenter: Dr. Raman (Director Laboratory, Analys PLtd., India)
</blockquote>
<blockquote>
Dr. Raman is the Director of Analys laboratory private limited, Hyderabad. Dr. Raman has earned his doctorate in analytical chemistry from Acharya Nagarjuna University, Guntur, India. He has more than three decades of experience in analytical R&amp;D in pharmaceutical industry. Dr. Raman has been a member of the board of studies in educational institutions. He has more than 25 publications to his credit on the development and validation of analytical methods in HPLC, UPLC, IC and GC-MS techniques.
</blockquote>
<blockquote>
Presenter: N. Kothandaraman (PM Ion Chromatography, Metrohm India PLtd.)
</blockquote>
<blockquote>
Mr. Niranjan Kothandaraman holds a M.Sc. degree in Applied Chemistry from Regional Engineering College, Trichy, India. Joined as an Application Chemist at Metrohm India and has good knowledge and working experience with all the analytical instruments from Metrohm AG. Having got an opportunity in marketing, currently he is working as a Product Manager at Metrohm India for Ion Chromatography, Voltammetry and Elga Water Purification Systems and is responsible for pan India business. He has been with Metrohm India since last 24 years.
</blockquote>

Metrohm: From APIs to Impurities and Excipients – Ion Chromatography for Pharmaceutical Analysis

From APIs to Impurities and Excipients – Ion Chromatography for Pharmaceutical Analysis

In a joint webinar we will introduce you to applied ion chromatography.

Ion Chromatography for Pharmaceutical Analysis

Join us for an insightful virtual town hall dedicated to a comprehensive discussion of the newly published EPA Method 1621 for Determination of AOF in Aqueous Matrices by CIC. The method marks a significant breakthrough in environmental monitoring, offering a novel approach for screening and quantification of fluorinated organic compounds.
This event aims to facilitate an in-depth exploration of the method, its methodological aspects, practical applications, regulatory considerations and the path forward for its implementation. 
A diverse panel of industry experts who helped develop and drive Method 1621 to completion will share their insights. Attendees will have the chance to interact with the pannel during a live Q&amp;A session, where they can ask questions and engage in discussions with:
<ul>
<li>Dr. Bharat Chandramouli, SGS</li>
<li>Dr. Chris Impellitteri, The Water Tower </li>
<li>Charles Nesland, Eurofins </li>
<li>Nick Nigro, Pace </li>
<li>Dr. Jay Gandhi, Metrohm USA</li>
</ul>
Highlights
<ul>
<li>Methodological Insights: Gain a deeper understanding of the technical aspects and methodology behind EPA Method 1621.</li>
<li>Practical Applications: Explore real-world applications and case studies demonstrating the utility of Method 1621 in environmental monitoring.</li>
<li>Regulatory Considerations: Learn about the regulatory implications and compliance requirements associated with the implementation of Method 1621.</li>
<li>Path Forward: Discuss the future prospects, challenges, and opportunities for further development and adoption of Method 1621.</li>
</ul>

Metrohm: AOF Method 1621 Virtual Town Hall

AOF Method 1621 Virtual Town Hall

In-depth exploration of the method 1621, its methodological aspects, practical applications, regulatory considerations and its implementation. 

LCMS webinars focusing on IC - page 6