Join analytical chemist Dr. M. Farooq Wahab from the University of Texas at Arlington as he breaks down the science behind chromatographic peak shapes in this episode of the Concentrating on Chromatography podcast. Perfect for undergraduate chemists and researchers alike, this conversation covers:<ul><li>What makes an ideal chromatographic peak shape and why it matters &nbsp;</li><li>Common reasons your HPLC peaks might show tailing, fronting, or distortion &nbsp;</li><li>Practical tips for diagnosing and troubleshooting peak shape problems &nbsp;</li><li>How to use visual and digital tools (like Excel) to analyze your chromatogram data beyond basic numbers &nbsp;</li><li>The importance of baseline correction, denoising, and signal processing in chromatography &nbsp;</li><li>Advice for students and early researchers aiming to excel in analytical chemistry</li></ul>Dr. Wahab shares lively insights from his research and decades of experience, revealing the underlying physics, chemistry, and engineering behind the peaks you see—and why peaks tell the story of your chromatography.Whether new to HPLC or looking to deepen your understanding, this episode demystifies a critical topic that impacts every chromatographer.<h3>Video Transcription</h3>The interview with Dr. M. Farooq Wahab focuses on why chromatographic peak shape matters and how it can be used as a practical diagnostic tool. He explains that the ideal peak is a narrow, symmetric Gaussian shape because it’s easier to detect and integrate reliably, but real peaks often show tailing, fronting, broadening, or splitting, which can compromise quantitation and interpretation.Dr. Wahab groups the main causes of distorted peaks into three buckets: thermodynamic effects (overloading the column’s capacity), kinetic effects (multiple interaction sites causing slow desorption and tailing), and fluid-dynamic/packing effects (non-uniform packed beds leading to fronting, tailing, or split peaks). He also highlights chemical interactions with metal surfaces in LC hardware—especially strong binding of phosphate-containing compounds to iron/steel—that can cause severe tailing or even complete loss of the analyte, sometimes requiring cleaning with chelators like EDTA.He cautions that single-number metrics such as tailing factor or asymmetry are convenient but can hide important details, so analysts should assess the full peak profile, using more advanced evaluations (e.g., Gaussian/derivative-style tests) when needed. For troubleshooting, he recommends “back to basics” benchmarking: run the manufacturer’s QC method on a new column to separate instrument issues from method/column/operator errors.Finally, the discussion broadens to data handling and career advice. Dr. Wahab argues for reproducible, transparent data analysis (sharing code/supporting files) and encourages students to use accessible tools like Excel (and carefully verified AI help) to explore peak diagnostics, denoising, and baseline correction—often best understood via frequency-domain thinking. He closes by advising young scientists to build skills across the “four pillars” of analytical chemistry: chemistry, physics, mathematics, and scientific computation, and to pursue science with passion and realistic expectations.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

HPLC Peak Shapes Explained: Why Your Chromatography Peaks Are Not Perfect & How to Fix Them

In the week of February 23, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. SCIEX: SCIEX OS Software Migration – Connect with the Experts and Ask Your Questions</h5><ul><li>Tu, 24.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5957">Registration</a></li></ul>Join this live Q&amp;A to explore migration from Analyst to SCIEX OS, including validation, compliance, upgrade steps, and expert support for a smooth transition.<h5>2. Separation Science: Ion Pair HILIC-MS – A Powerful Characterization Method for Biomacromolecule Analysis</h5><ul><li>Tu, 24.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5909">Registration</a></li></ul>Discover how ion-pair HILIC-MS provides an effective alternative to RPLC-MS for advanced biomacromolecule characterization.<h5>3. SelectScience: Cruise Through Genomics Quantification and QC with Lunatic</h5><ul><li>Tu, 24.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5837">Registration</a></li></ul>Learn how Lunatic enables fast, dye-free DNA and RNA quantification for NGS and biobanking, delivering accurate purity and concentration data from 96 samples in under 10 minutes.<h5>4. Shimadzu Corporation: Unlock Faster Microbial Identification – A Guide to MicrobialTrack for Shimadzu’s MALDI</h5><ul><li>We, 25.2.2026 08:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5810">Registration</a></li></ul>Discover how MicrobialTrack enhances MALDI-TOF MS with genomics-driven algorithms, expanded databases, and streamlined workflows for reliable microbial identification.<h5>5. Phenomenex: The Future of PFAS Testing – Regulations, Innovation, and Contamination Mitigation</h5><ul><li>We, 25.2.2026 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5797">Registration</a></li></ul>Join this roundtable discussion covering regulatory scrutiny, evolving PFAS standards, and practical laboratory solutions.<h5>6. Mettler-Toledo: DirectInject-LC Virtual User Forum</h5><ul><li>We, 25.2.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5517">Registration</a></li></ul>Discover how DirectInject-LC enables real-time online HPLC analysis for process development, with insights from AstraZeneca, Genentech, and Takeda.<h5>7. Agilent Technologies: Dealing With Polar Analytes – What Are the Options?</h5><ul><li>We, 25.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5738">Registration</a></li></ul>Explore strategies to separate highly polar analytes using ion-pair RP, polar-modified phases, HILIC, and ligand-exchange chromatography beyond traditional C18.<h5>8. Thermo Fisher Scientific: Toward Early Detection of Congenital Disease Using Orbitrap Astral DIA MS/MS</h5><ul><li>Th, 26.2.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5933">Registration</a></li></ul>Learn how Orbitrap Astral MS in DIA mode enables ultra-sensitive detection of parasite-specific IgG variants for improved early diagnosis of congenital toxoplasmosis.<h5>9. Waters Corporation: Impurity Testing – Definitions, Guidelines, Analytical Reference Materials and Technologies</h5><ul><li>Th, 26.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5918">Registration</a></li></ul>Explore regulatory expectations for API impurities and how modern LC technologies and Empower™ software optimize and modernize impurity testing workflows.<h5>10. Milestone: Sample Preparation Workflow for Organic Pollutants and PFAS in Environmental Samples</h5><ul><li>Th, 26.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5805">Registration</a></li></ul>Discover efficient microwave extraction workflows for organic pollutants and PFAS to improve recoveries, reduce blanks, and meet EPA 1633A requirements.<h5>11. Thermo Fisher Scientific: 4D Performance Gains for Highly Multiplexed Gut Microbiome Metabolite Quantification</h5><ul><li>Th, 26.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5910">Registration</a></li></ul>Learn how advanced LC-MSⁿ workflows accelerate multiplexed targeted quantitation using mzCloud and Stellar MS for broader coverage and higher confidence.<h5>12. Waters Corporation: Leveraging SEC-MALS for Regulatory-Aligned Biosimilarity Assessment</h5><ul><li>Th, 26.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5811">Registration</a></li></ul>Discover how SEC-MALS supports biosimilar comparability by accurately characterizing molecular weight, aggregation, and key CQAs in line with FDA and ICH Q6B guidance.<h5>13. Shimadzu Corporation: Automated LCMS-Solution Ready for 24/7 Operation</h5><ul><li>Th, 26.2.2026 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5937">Registration</a></li></ul>Learn how Shimadzu’s automated LC-MS/MS solution standardizes sample preparation and supports continuous 24/7 operation in clinical laboratories.<h5>14. Agilent Technologies: Getting Peptide Characterization Right – Analytical and Regulatory Foundations for Confident Development</h5><ul><li>Fr, 27.2.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5942">Registration</a></li></ul>Episode 1 of Peptide 360 explores analytical and regulatory foundations of peptide characterization using integrated LC-MS for compliant GLP-1 development.<h5>15. SelectScience: The PFAS Measurement Crisis – A Roundtable Discussion</h5><ul><li>Fr, 27.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5841">Registration</a></li></ul>Join this expert roundtable to discuss limitations of targeted PFAS methods, non-targeted analysis approaches, next-generation standards, and closing the PFAS data gap.

Webinars LabRulezLCMS Week 09/2026

Automated Mag-Net Enrichment Unlocks Deep and Cost-Effective LC–MS Plasma Proteomics

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Metrohm

Mettler-Toledo

Unchained Labs

Phenomenex

Thermo Fisher Scientific

Shimadzu Corporation

Waters Corporation

<ul>
<li>Learn the various optical performance parameters</li>
<li>Learn which parameters need to be monitored</li>
<li>Benefits of automated performance qualification</li>
<li>Solution for data integrity compliance in optical instrument qualification</li>
<li>Overview of available service offerings from METTLER TOLEDO</li>
</ul>
During the webinar, we will go into depth about these questions and more:
<h5>What certified reference materials (CRMs) are specified for wavelength accuracy and precision tests by both Pharmacopeias?</h5>
USP: Rare earth oxide solutions/glasses (Ce, Ho, Didymium) or Hg/D2 emission lines
Ph. Eur.: Ho(ClO4)3, Ce2(SO4)3 solutions, or Ho/Didymium glasses, or Hg, D2, Ne, Xe lines
<h5>What CRMs are specified for photometric accuracy and precision tests by both Pharmacopeias?</h5>
USP: for UV range, Nicotinic acid in HCl (6 – 60 mg/L, up to 2.5 A, 213 and 261 nm) or K2Cr2O7 in HClO4 (6 – 200 mg/L, up to 3.0 A, 235, 257, 313, 350 nm); for visible range, neutral density glass filters (up to 3.5 A, 440, 465, 546.1, 590, and 635 nm)
Ph. Eur.: Suitable solid and liquid filters such as certified PDC or neutral density filters; or, instead of certified PDC, Nicotinic acid in HCl.
<h5>What CRMs are specified for photometric linearity tests by both Pharmacopeias?</h5>
USP and Ph. Eur., respectively, specify to use the materials for photometric accuracy tests also for photometric linearity tests.
<h5>Target Audience</h5>
Lab Managers, Lab Technicians, System Owners, Quality Assurance Managers, Quality Assurance Operators
<blockquote>
Presenter: Dr. Fabian Müller (Product Manager SPG UV/VIS)
</blockquote>
<blockquote>
Presenter: Dr. Hans-Joachim Muhr (Business Development Manager BioTech)
</blockquote>

METTLER TOLEDO: Pharmacopeia – What to Check on UV Vis Spectrophotometers? 

Pharmacopeia – What to Check on UV Vis Spectrophotometers? 

USP and Ph. Eur. Requirements Placed on UV/Vis Spectrophotometers

Pharmacopeia – What to Check on UV Vis Spectrophotometers?

Learn how Light Scattering can benefit your drug development!
The scientific community aims to enhance transparency and reliability in published research, with a specific focus on the quality of biological reagents, notably recombinant proteins. Concerns have been raised regarding irreproducible results, prompting discussions on common quality issues associated with recombinant proteins and their impact on downstream applications. In response, professionals in protein purification and characterization have collaboratively developed guidelines for improved quality control.
These guidelines include minimal information requirements for protein identity, production parameters, and long-term stability, as well as a minimal set of quality tests for purity, homogeneity, and identity. Additional recommendations cover DNA contamination, “spectral and thermal denaturation signatures”, homogeneity, “competent fraction”, storage conditions, batch-to-batch reproducibility, and other factors based on intended applications. 
Evaluation of these guidelines over a one-year period suggests that their implementation can enhance experimental reliability and optimize protein quality. Investing in protein QC benefits all stakeholders in life sciences, including researchers, editors, and funding agencies, by improving data accuracy and minimizing resource wastage
Key learning topics:
<ul>
<li>The latest guidelines for Quality control of Protein purification and characterisation 
</li>
<li>How these guidelines can enhance reliability and improve protein quality in your labs
</li>
<li>How to reduce wastage and improve data accuracy in protein quality control
</li>
</ul>
Who should attend?
<ul>
<li>Lab Managers and Scientists working in upstream recombinant protein production and QC
</li>
<li>Lab Managers and Scientists working in downstream protein purification QC
</li>
</ul>
<blockquote>
Presenter: Dr. André Matagne (Full Professor, University of Liège, Belgium)
</blockquote>
<blockquote>
Dr. Matange is a Full Professor at the University of Liège, Belgium, where he is the chair at the Centre for Protein Engineering within the Faculty of Sciences.
</blockquote>
<blockquote>
With a background in biochemistry, his research is primarily focused on proteins, particularly exploring their folding, stability, and biological activity. Notably, he has played a pivotal role in the development of Robotein®, an advanced technological platform designed for to high throughput protein expression, purification, formulation, and analysis.
</blockquote>
<blockquote>
Since 2016, Dr.Matagnehas been honored as an elected titular member of the Royal Academy of Sciences in Belgium.
</blockquote>

Waters Corporation: Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Learn how Light Scattering can benefit your drug development.

Quality Control of Purified Proteins to Improve Research

Karl Fischer (KF) titration is renowned for its rapid and precise measurement of water content in a wide variety of samples.
Understanding the factors that can impact the accuracy of your Karl Fischer titration process is crucial for ensuring optimal results.
Join us for an in-depth webinar that will delve into the critical factors affecting the Karl Fischer titration process and provide a comprehensive overview from start to finish. Participants will gain insights into essential procedures such as titer determination and explore critical applications.
This session is designed to enhance your understanding and improve the precision of your titration techniques.
<h4>Program Overview</h4>
<ul>
<li>Exploring the Components of a Volumetric Karl Fischer Titration Apparatus: Gain a detailed understanding of each element in the apparatus to enhance your practical knowledge.
</li>
<li>Introduction to Karl Fischer Reagents &amp; Standards: Familiarize yourself with the variety of reagents &amp; standards used in Karl Fischer titration and their specific applications.
</li>
<li>The Importance of Titer Determination: Learn why accurate titer determination is crucial for reliable results and discover the best practices for conducting it effectively.
</li>
<li>Analyzing Challenging Samples: Delve into practical examples that demonstrate how to handle and accurately analyze complex samples.
</li>
<li>Innovations in Titration Technology: Learn about our advanced titration technology that utilizes SmartChemicals to seamlessly transfer data to the Karl Fischer titrator.
</li>
</ul>
<blockquote>
Presenter: Bettina Straub-Jubb (Global Product Manager, Karl Fischer Titration at the Life Science Business of Merck KGaA, Darmstadt, Germany)
</blockquote>
<blockquote>
Bettina is the Global Product Manager for Karl Fischer titration and general titration within the Analytical Essentials team at Merck KGaA, Darmstadt, Germany. She has over 20 years of experience in various facets of titration, including Karl Fischer titration, instrumental analysis reagents, and reference materials, contributing significant expertise to her position. Bettina is deeply familiar with all steps of the titration process and collaborates closely with the application laboratories and R&amp;D department to continually enhance titration methodologies. She holds a degree in Chemical Technology from the Darmstadt University of Applied Sciences, Germany, and completed an apprenticeship as a medical technical laboratory assistant at the Medical Technical Academy in Esslingen, Germany.
</blockquote>
<blockquote>
Presenter: Thomas Hitz (Application Chemist, METTLER TOLEDO)
</blockquote>
<blockquote>
Thomas currently serves as a technical advisor for product development at METTLER TOLEDO, Nänikon, Switzerland. With over 15 years of experience in application development, sales, and customer training, he provides expert support for complex automation solutions in both general and Karl Fischer titration. He holds a degree in biochemistry from the University of Zürich and completed his PhD in 2003 at the Swiss Federal Institute of Technology Zurich in the Department of Material Sciences.
</blockquote>

Mettler Toledo: Optimize Your Volumetric Karl Fischer Titration

Optimize Your Volumetric Karl Fischer Titration

Critical factors affecting the Karl Fischer titration process and a comprehensive overview from start to finish.

Understanding and measuring pH accurately is crucial in both chemical and biological contexts, affecting a range of applications.
For example, in lithium batteries, precise pH control optimizes its performance and ensures safety. In paint, it determines the color consistency, stability, and product longevity. Similarly, in plant-based proteins, pH influences protein extraction and quality, affecting texture and nutritional value. However, the complex matrices and diverse physical properties of these samples often interfere with pH measurements, posing significant challenges.
Join our webinar to learn how to overcome these challenges and optimize your pH measurement results in both chemical and biological samples. Let our experts guide you through advanced techniques, best practices, and practical solutions tailored to different applications.
<h4>Program Overview</h4>
<ul>
<li>Introduction to pH measurement: Learn about the importance of pH accuracy in fields like chemistry and biology.
</li>
<li>pH in chemicals: Discover how precise pH monitoring ensures chemical stability, reactivity, and shelf life. Learn tips for managing pH-dependent chemical processes for optimal results.
</li>
<li>pH in biological samples: Explore the critical role of pH in physiological functions, enzyme activity, and disease diagnosis.
</li>
<li>Techniques and best practices: Discuss pH measurement techniques, calibration, buffers, and overcoming common challenges.
</li>
<li>Interactive Q&amp;A session
</li>
</ul>
<blockquote>
Presenter: Dr Reena Mascarenhas
</blockquote>
<blockquote>
Dr. Reena is a seasoned electrochemist with over 5 years of dedicated experience at METTLER TOLEDO. Her in-depth knowledge and expertise in the field have made her a sought-after speaker for live webinars. With a strong academic foundation and a passion for electrochemical advancements, Dr. Reena is committed to sharing her insights and contributing to the growth of the scientific community.
</blockquote>

Mettler Toledo: How to Measure pH in Chemicals and Biological Samples

How to Measure pH in Chemicals and Biological Samples

How to overcome these challenges and optimize your pH measurement results in both chemical and biological samples.

Analytical testing in process development for protein therapeutics is demanding for several reasons: large number of samples, tedious and labor-intensive sample prep, and relative long analysis time for LC-MS.
Bioreactor samples also require careful preparation to enable high quality and sensitive profiling of critical quality attributes (CQAs), especially for low level post translational modifications (PTMs). 
In this webinar, we present automated workflows that encompass simplified sample prep (Protein A purification, and/or mAb subunit digestion) to rapid LC-MS analysis through data processing. We share application examples of LC-MS subunit analysis using the Genovis FabRICATOR® (IdeS) enzyme to compare CQAs of biosimilars and innovator mAbs:
<ul>
<li>Automated mAbs CQA assessment of cell culture samples - intact mass analysis and subunit analysis (presented by Andreas Nageli, Genovis)
</li>
<li>**Automated mAbs CQA assessment comparing Biosimilars vs Innovator - Subunit analysis for glycan profile and for modification of unpaired cystines (CQA) with samples from clone selection and from downstream processing (a Similis Bio-Waters Collaboration)
</li>
</ul>
You will learn from this webinar how to make your analytics higher throughput, with less human intervention, all while providing high quality, sensitive and specific characterization data, ultimately leading to better, faster decision making.**
Secure your spot to see the reveal of the latest version of the Waters Bioprocessing Walk-up Solutions. Be the first to learn how Waters is enabling bioprocess teams to acquire high quality LC-MS analytics through better automation at the point of need.
<blockquote>
Presenter: Samantha Ippoliti (Principal Scientist, Discovery &amp; Development- Biopharma, Waters Corporation)
</blockquote>
<blockquote>
Samantha (Sam) joined Waters (Milford, MA) in 2018 and has worked on a variety of applications for LC-MS based biopharmaceutical characterization, including peptide mapping analysis and method development, and intact/subunit analysis via reversed phase (RP) and ion exchange (IEX) -MS. Sam has experience with analysis using BioAccord, Xevo series, Synapt XS, and Cyclic IMS LC-MS instruments. Prior to joining Waters, she was part of the LC-MS characterization group supporting a biopharmaceutical developability assessment group at Novartis in Cambridge, MA. (Sam acquired a BS-MS in Chemistry from Northeastern University in 2012.)
</blockquote>
<blockquote>
Presenter: Andreas Nageli, PhD (Principal Scientist, Genovis)
</blockquote>
<blockquote>
Andreas joined Genovis in 2018. As Principal Scientist he is involved in the development of new SmartEnzyme products and applications as well as supporting customers in introducing Genovis SmartEnzymes into their assays. Andreas also heads business development at Genovis. He holds a PhD in microbiology from ETH in Zurich, Switzerland.
</blockquote>

Waters Corporation: Automated LC-MS Workflow for CQA Assessment of Protein Therapeutics with Speed and Simplicity for Process Development

Automated LC-MS Workflow for CQA Assessment of Protein Therapeutics with Speed and Simplicity for Process Development

Automated workflows that encompass simplified sample prep to rapid LC-MS analysis through data processing.

Automated LC-MS Workflow for CQA Assessment of Protein

Today, tomorrow, and forever – PFAS, the “forever chemical”, have emerged as one of the greatest public health concerns of our time, infiltrating our environment and food supply. Herein, join us on Digital Classrooms for an in-depth exploration of PFAS, tracing their origins in everyday consumer products and examining their potential health implications.Our experts, Dr Yap Siew Qi and Elton Goh, will guide you through this critical topic, exploring the regulatory landscape with insights into EFSA and FDA guidelines. They will also introduce Shimadzu's innovative LC-MS/MS solutions, featuring the latest LCMS-TQ RX series. Discover how their robustness, sensitivity, and accuracy can enable effective detection of PFAS in complex food and environmental samples.Let’s work together to overcome global PFAS challenges. Register now to stay informed on this pressing issue!<h5>Learning Objectives:</h5><ul><li>Understand the implications of PFAS presence in food and environment &nbsp;</li><li>Navigate the evolving regulatory landscape for PFAS &nbsp;</li><li>Discover the capabilities of Shimadzu LCMS-TQ RX to detect PFAS in food and environmental samples</li></ul><blockquote>Presenter: Goh Wan Yu Elton (Market Specialist Food, Shimadzu (Asia Pacific) Pte Ltd)Elton is a dedicated and experienced Food Market Specialist at Shimadzu, bringing over nine years of expertise in food safety and analytical chemistry to his role. His career began at the Singapore Food Regulatory Board, where he spent seven years honing his skills and developing a profound understanding of regulatory standards and testing protocols. With a passion for knowledge and innovation, Elton transitioned to the private sector, contributing significantly to the advancement of analytical techniques and the development of novel food safety solutions during his two-year tenure at a research and development centre.Now at Shimadzu, Elton continues to excel, leveraging his expertise to develop cutting-edge analytical methods for detecting and quantifying various compounds in food products. His commitment to food science is evident in his efforts to enhance safety standards, build consumer trust, and make meaningful contributions to the global food industry.Presenter:&nbsp;Yap Siew Qi (LCMS Product Specialist, Shimadzu (Asia Pacific) Pte Ltd)Yap Siew Qi is an experienced professional in analytical chemistry, with a strong focus on liquid chromatography-mass spectrometry (LCMS). Her career commenced as a Research Assistant at the NUS Life Sciences Institute, where she acquired substantial experience in scientific research and laboratory techniques. This role was pivotal in developing her comprehensive understanding of life sciences, setting the stage for her future contributions to analytical chemistry and instrumentation.In 2022, her journey continued at Shimadzu (Asia Pacific), where she joined as an Application Chemist, focusing on LC/LCMS. In this capacity, she refined her expertise in LCMS technology, delivering prompt application support and technical solutions for the customers. Her exceptional skills and knowledge in LCMS soon led to her advancement to the position of Product Specialist. In this role, she continues to provide specialized knowledge and support, demonstrating her dedication to the progression of analytical chemistry and her proficiency in applying innovative technology within the field.Presenter:&nbsp;Mr. Ramaswamy Parthiban (Assistant Vice President, TUV SUD South Asia)Mr. R Parthiban has a robust background in operations management and quality assurance within the testing, inspection, and certification industry. He currently serves as AVP at TUV SUD South Asia, a position he has held since March 2022. Prior to this, he was the National Head at Prime Certification &amp; Inspection from April 2020 to June 2021. His experience also includes a significant role as Director of Operations at ALS Testing Services India Pvt Ltd from July 2018 to March 2020, where he led strategic initiatives and operational excellence.Earlier in his career, Mr. Parthiban held leadership roles including VP Operations at Merieux NutriSciences and Laboratory Manager for Chemistry at Exova Bahrain/KSA. His extensive experience in the industry is complemented by his earlier positions as Senior Manager at Coca-Cola and Laboratory Manager at SGS India Private Ltd. He began his career as a Research Associate at the John F. Welch Technology Center and ITC R&amp;D Center, eventually progressing to an Executive role in Quality Assurance at Sanmar Speciality Chemicals Ltd. Mr. Parthiban's career is marked by his expertise in quality systems, operational management, and strategic leadership in both national and international contexts.</blockquote>

Shimadzu: Discover The Latest LC-MS/MS Innovations For PFAS Challenges

Discover The Latest LC-MS/MS Innovations For PFAS Challenges

Discover how their robustness, sensitivity, and accuracy can enable effective detection of PFAS in complex food and environmental samples.

Supercritical Fluid Chromatography (SFC), a chromatographic technique using a supercritical CO2 mobile phase, has been known for decades but was seldom used due to the popularity of normal and reverse phase liquid chromatography.Several years ago, SFC found a niche in chiral resolution when it was found that the physical characteristics of supercritical fluids can offer unique separations when compared to traditional liquid chromatography methods. Since then, these unique separations and “greener” aspect of CO2 have sparked new interest broadening SFC applications. Shimadzu, the leader in innovative SFC instrumentation, offers an array of analytical and preparative SFC systems that allow researchers easily access this growing technology. In this webinar, we’ll look at how Shimadzu’s SFC instruments and how our unique features are currently used in a variety of cutting edge applications for small and large molecules.<blockquote>Presenter: Stephen Swartz (Business Development Specialist, Shimadzu Scientific Instruments)Steve has been involved with the pharmaceutical industry for over 33 years. As a medicinal chemist at DuPont, Bayer, and Bristol Myers Squibb, he worked in multiple therapeutic areas supporting early phase discovery. After leaving the lab, Steve worked for several instrumentation companies in scientific support, sales, and business development. Since joining Shimadzu in 2020 as Business Development Specialist, he has worked with customers in the pharma and biopharma markets using his experience to help optimize workflows from early discovery to IND and beyond.Presenter:&nbsp;Kevin Wons (Market Manager - Pharma/BioPharma, Shimadzu Scientific Instruments)Kevin has recently joined Shimadzu as Market Manager for Pharma/BioPharma. He has spent the last 6 years at AstraZeneca in the Analytical Sciences Department for product and process characterization for biologics in the AstraZeneca pipeline. Kevin has applications experience with HPLC and LC-MS to do Tryptic Peptide Mapping, Intact Mass Analysis, Subunit Mass Analysis, and Oligosaccharide Profiling. For his last 3 years, he acted as the Glycan Subject Matter Expert (SME) while at AstraZeneca. His work experience also includes Maryland Psychiatric Research Center, where he prepared animal tissue samples such as Brain, Liver, Blood, and Placenta to measure kynurenine pathway metabolites on GC/MS and HPLC. He has a Master’s degree in Professional Studies (MPS) focused on Biotechnology which prepares science professionals to fill management and leadership roles.</blockquote>

Shimadzu: Shimadzu's Recent Advances in SFC

Shimadzu's Recent Advances in SFC

How Shimadzu’s SFC instruments and how our unique features are currently used in a variety of cutting edge applications for small and large molecules.

Titration is generally considered a fairly simple analytical technique. But what do you do, if your titration results are not what they should be? Enter Robert Tobler, Senior Application Specialist Titration at Metrohm International Headquarters!In his webinar on September 18, Robert will show you what typical errors can occur during a titration – and how to avoid or remedy them. Focusing on troubleshooting, Robert will cover everything from the electrode to the setup of your titrator to titration parameters and calculation of &nbsp; the result. The following questions give you an idea of the scope and practical relevance of this webinar:<ul><li>How important is calibration?</li><li>Do I really need to stir the titration solution – and why?</li><li>What do I do, if several equivalence points are detected – or none at all</li><li>How to clean the electrode properly?</li></ul>These questions and many more will be answered step by step so that everyone can follow and understand. During a Q&amp;A session at the end of the webinar, you can ask Robert any question you may have about titration.<blockquote>Presenter: Robert Tobler (Senior Application Specialist Titration, Metrohm International Headquarters)After his apprenticeship as a chemical laboratory technician and further training as a biomedical analyst, Robert Tobler studied chemistry at the Zurich University of Applied Science in Waedenswil, Switzerland. He joined Metrohm in 2015 as an application specialist titration. Since then, Robert has become an expert in applied titration sharing his expertise through the global network of Metrohm subsidiaries.</blockquote>

Metrohm: Troubleshooting titration: essential know-how for quality results

Troubleshooting titration: essential know-how for quality results

What typical errors can occur during a titration – and how to avoid or remedy them.

Troubleshooting titration: essential know-how for quality

Per- and Polyfluoroalkyl Substances (PFAS) are exceptionally versatile chemicals and have seemingly endless applications that include more than 12,000 different compounds.Due to the persistent nature of these compounds, as well as their ability to be easily transported through the environment, there is a significant concern for the presence of PFAS in the human body. A LC-MS/MS method utilizing microelution SPE for sample cleanup, presented for analysis of seven PFAS, identified significant by National Academies of Sciences, Engineering, and Medicine for clinical research and biomonitoring in public health labs.&nbsp;<h4>Who Should Attend:</h4><ul><li>Any scientists interested in LC-MS/MS and sample preparation or anyone curious about PFAS from biological samples</li></ul><h4>Key Learning Points:</h4><ul><li>Learn key steps to LC-MS/MS and sample preparation of biological samples</li><li>Understand potential Challenges when extracting PFAS from biological samples</li><li>Find advantages of using Micro elution SPE sorbent technology</li></ul><blockquote>Presenter: Shahana W. Huq (Senior Application Scientist, Phenomenex)Shahana is a Senior Application Scientist focusing on emerging technologies and solutions within Clinical Research and Sample Preparation, at the Phenomenex Applications Laboratory since the year 2000. She holds an MS in Biochemistry from California State University, Los Angeles. Her work involves experimental design, analytical method development, optimization, and troubleshooting. &nbsp;Furthermore, she has extensive expertise in R&amp;D product innovation and application development, as well as hands-on experience in sample preparation and LC-MS/MS. Shahana’s drive, and vision of the clinical field has motivated her to participate in various scientific publications and even as a coauthor of Phenomenex patent on sample preparation products. Currently, Shahana works closely with global customers in the applied market, providing technical support and consultation services as well as onsite seminars and webinars to promote peer development. &nbsp;Presenter: Richard Jack, PhD (Global Market Development Manager, Phenomenex)Richard is the global market development manager for the environmental and food markets at Phenomenex. He has over 18 years of experience with chromatography and mass spectrometry for the environmental, food, cannabis, semiconductor, chemical, and pharmaceutical industries. Jack has collaborated with global regulatory agencies to develop validated methods through new applications, instrumentation, column chemistries, and software. He is a former EPA scientific advisor for the EPA’s panel on hydraulic fracturing and a coauthor for EPA 557 and 557.1, ASTM D8001, and updates to D4327 and D6919 methods. He is currently the second vice chairman for the ASTM D19 subcommittee on water analysis. Previously, Jack was a vertical marketing manager with Thermo Fisher Scientific, Dionex, and Hitachi High Technologies, where he designed analytical instrumentation, including IC and HPLC systems, pumps, autosamplers, and a variety of detectors. He received his PhD in biochemistry and anaerobic microbiology from Virginia Tech in Blacksburg, Virginia. He received his master’s degree in ecology from the University of Tennessee in Knoxville.</blockquote>

Phenomenex: LC-MS/MS Analysis of PFAS in Bovine Serum for Clinical Research Using Microelution SPE

LC-MS/MS Analysis of PFAS in Bovine Serum for Clinical Research Using Microelution SPE

A LC-MS/MS method utilizing microelution SPE for sample cleanup, presented for analysis of seven PFAS.

LC-MS/MS Analysis of PFAS in Bovine Serum

As subcutaneous delivery of high-concentration biologics becomes more popular, optimizing their formulations becomes more complicated. Some excipients play better with one antibody, not another, or only help under specific conditions. Testing formulations at high protein concentration makes lower sample consumption and efficient assays a must-have. High-throughput, low volume solutions, designed for biologics, will speed up those formulation studies. Here, we present a case study on how to prepare monoclonal antibodies at high and low concentrations with some common excipients and screen for effects on quality, stability, and viscosity.The case study will illustrate how to produce all this data seamlessly, allowing the researcher to rate and rank formulations for their influence on the analyte and to quickly narrow down the optimal excipients.<blockquote>Presenter: Ross Walton (Senior Application Scientist, Analytics, Unchained Labs)Moderator:&nbsp;Chloe (Oxford Global)</blockquote>

Unchained Labs: Fast track formulation with biologics screening in a snap

Fast track formulation with biologics screening in a snap

Explore how to optimize high-concentration biologic formulations using low-volume, high-throughput tools. Case study shows impact on quality, stability.

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