This compact device saves up to 90% of mobile phase by redirection of the pure solvent to the solvent reservoir during the isocratic HPLC. The device is powered by 5 V DC from computer USB port or power adapter. Working parameters (Threshold and Delay) are set using user friendly software.<blockquote>Price: 635<bdi>&nbsp;€ ex VAT</bdi></blockquote>The UFO Solvent Recycler continuously monitors the output signal of the chromatography detector and displays its current value in the application on computer. A high-resolution analog-to-digital converter provides data for further evaluation in the built-in processor.If the input signal level exceeds a preset value (Threshold), the UFO recycler will redirect the flow to the waste. When the signal drops, the solvent recycler waits for the transport delay and then switches the mobile phase back to the reservoir. An autosampler injection marker connected to the UFO recycler START input can be used to zero the input signal at the time of injection.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UFO_schema_6a4cdc0ed4/UFO_schema.png" alt="Watrex: Principle and process of mobile phase recycling during isocratic HPLC using the UFO system" width="1348" height="1378"><h3>FEATURES</h3><ul><li>Very compact design</li><li>Simple operation</li></ul><h3>TECHNICAL SPECIFICATION</h3><ul><li>Detector compatibility: compatible with any HPLC detector</li><li>Connection: 1/16″ O.D. tubing, 1/4″-28 flat bottom fittings</li><li>Maximum pressure: 30 p.s.i./0,2 MPa</li><li>Wetted material: PEEK, PTFE</li><li>Input range: +/- 1 V or +/- 100 mV, user selectable</li><li>Computer connection: USB-A</li><li>TTL/contact closure input: configurable (ZERO, start, valve position)</li><li>Power: 5V DC/&lt;100 mA (power supply or computer USB port)</li><li>User interface: PC Windows based software</li></ul><h3>Ordering information:</h3><h5>PN/Component:</h5><ul><li>UFO000-001 UFO™ Solvent Recycler , PEEK version</li><li>UFO000-002 UFO™ Solvent Recycler , PTFE version</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_UFO_1_01268632dd/Watrex_UFO_1.jpg" alt="Watrex: Introducing Watrex UFO Solvent Recycler." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_UFO_1_01268632dd/thumbnail_Watrex_UFO_1.jpg 177w," sizes="100vw" width="1310" height="1152"><blockquote><h4>Selected document from Watrex in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=93">LabRulesLCMS library</a>:</h4><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Watrex_catalog_2024_ba97395f92.pdf">Watrex product catalog 2024</a></h5><ul><li>HPLC, GPC/SEC, Sample Preparation, LC columns, Consumables</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1341">WATREX SYRINGE FILTERS</a></h5><ul><li>Consumables</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=48&amp;distributorItems=59&amp;manufacturerItems=93">Watrex HPLC COLUMNS</a></h5><ul><li>Consumables, LC columns</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Watrex_Clean_Water_for_Quality_Results_Rely_on_Our_Water_Systems_dc404f75df.pdf">Clean Water for Quality Results: Rely on Our Water Systems</a></h5><ul><li>Laboratory instruments</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/300">Watrex - LSS-205 Liquid Sensing System</a></h5><ul><li>Laboratory instruments, HPLC</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/4671">8 points on how to care for columns</a></h5><ul><li>Consumables, LC columns</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=179&amp;distributorItems=59&amp;manufacturerItems=93">Watrex WATER PURIFICATION SYSTEMS</a></h5><ul><li>Laboratory instruments &nbsp;</li></ul></blockquote>

Introducing Watrex UFO Solvent Recycler

16th Multidimensional Chromatography Workshop (MDCW) - Program

From December 1st to December 31st, 2024, when you purchase any new Mnova license, you'll receive an additional plugin of your choice FREE for 1 year.<blockquote><h5>Check out our tutorial videos for Peak Purity Assessment in LCMS with Mnova MSChrom, Advanced Chemometrics, and BioHOS.</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://youtu.be/FkJ43lQrMwI">Peak Purity Assessment for LCMS using MCR mode in Mnova MSChrom</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://youtu.be/nab8pR2RAbE">MCR tool in Mnova chemometric solutions: Advanced Chemometrics and BioHOS</a></li></ul></blockquote>&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Holiday_Special_Get_More_from_Mnova_This_December_Buy_1_Get_1_255c1413bd.jpg" alt="Mestrelab Research: Mestrelab Holiday Special - Get More from Mnova This December: Buy 1 - Get 1!" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Mestrelab_Holiday_Special_Get_More_from_Mnova_This_December_Buy_1_Get_1_255c1413bd.jpg 245w," sizes="100vw" width="1920" height="1080">Whether you're in industry, government, or academia, this limited-time offer is the perfect way to enhance your analysis toolkit with our powerful suite of tools for NMR, LC/GC-MS, and Electronical &amp; Vibrational Spectroscopic techniques. It’s also an excellent choice for exploring our solutions tailored to specific applications, such as <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/3VgxIne">prediction</a>, <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/4eYNRoC">reaction monitoring</a>, <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/49iDUBh">structure elucidation</a> and <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/3CUNxd6">verification</a>, <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/49gfisB">quantification</a> and <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/3Zu3EHs">mixture analysis</a>, <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/3B8Jvx9">screening</a>, <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/3CQKwuv">chemometrics</a>, <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/41ddyOV">database management</a>, and <a target="_blank" rel="noopener noreferrer" href="https://bit.ly/3ZB1aWL">more</a>!<h4>How It Works:</h4><ol><li>Buy any new Mnova license.</li><li>Choose an additional plugin (of equal or lesser value) for free for 1 year.</li><li>Expand your research capabilities with unmatched tools!</li></ol>Don’t wait—claim your offer now!<h4>Offer Details:</h4><ul><li>Valid: December 1–31, 2024</li><li>Exclusions: Mnova Gears and its plugins/bricks, USP-ID, Mnova Web, Mbook.</li><li>Discounts: Cannot be combined with other discounts (except volume discounts).</li></ul>Act now and give yourself the gift of innovation this holiday season.<a target="_blank" rel="noopener noreferrer" href="https://bit.ly/41euuVs">Visit our web store</a> or <a href="mailto:sales@mestrelab.com" target="_blank" rel="noopener noreferrer">contact</a> us directly to claim your offer now!<blockquote><h4>About <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/companies/298">Mestrelab Research</a>:</h4>For two decades, we have provided cutting-edge tools to enhance analytical data processing, analysis, and reporting experience. Today, our comprehensive range of products and solutions extends beyond NMR to include LC/GC-MS and other spectroscopies. These tools empower users to automate routine tasks, streamline workflows, and focus on what truly matters—extracting meaningful insights from their data.</blockquote>

Mestrelab Holiday Special - Get More from Mnova This December: Buy 1 - Get 1!

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The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography (MDC) Workshop

Mestrelab Research is a scientific software company with nearly two decades of expertise, specializing in providing advanced solutions in the field of analytical chemistry. As a fast-growing company, we have doubled in size over the past five years, now boasting over 90 employees spread across headquarters in Santiago de Compostela (Spain), as well as offices in Europe, Asia, and the USA.

Mestrelab Research

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Watrex Praha

SelectScience

Shimadzu Corporation

SCIEX

Waters Corporation

The development of peptide drugs necessitates efficient bioanalytical assays for accurate measurement in biologicals. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is preferred technology for its specificity and sensitivity. However, LC-MS/MS assays for peptides such as the high-profile diabetes and weight loss GLP-1 receptor agonist Semaglutide, pose significant method development challenges.In this webinar, we present new data demonstrating a comprehensive and streamlined approach to optimized LC-MS/MS quantification of peptides, addressing the common challenges of efficient sample preparation, MRM selection, non-specific binding, sensitivity and robustness, through the example of the development of an assay for the quantitation of Semaglutide in plasma.<h5>Key Learning Objectives:</h5><ul style="list-style-type:disc;margin-top:0cm;" type="disc" id="isPasted"><li style="line-height:115%;margin-bottom:10.0pt;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;">Learn step-by-step how to streamline bioanalysis workflows for large peptides such as Semaglutide.</li><li style="line-height:115%;margin-bottom:10.0pt;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;">Discover practical solutions to common obstacles like non-specific binding and efficient mrm optimisation.</li><li style="line-height:115%;margin-bottom:10.0pt;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;">Gain insights into boosting sensitivity without compromising the reliability of your bioanalytical methods</li></ul><div><blockquote>Presenter: Samantha Ferries (Senior Applications Chemist, Waters Ltd)Samantha Ferries received her PhD in proteomics from the University of Liverpool in 2018. Since joining Waters in 2018, Samantha has worked on a variety of application areas including Biomedical Research, Pharmaceuticals and Food &amp; Environmental, with a focus on LCMS/MS method development. In 2021 Samantha was part of the team that worked to develop the SARS-CoV-2 LCMS Kit (RUO) to detect &amp; quantify SARS-CoV-2 signature NCAP peptides.</blockquote></div>

Mastering the Quantitative Bioanalysis of Large Peptides and Proteins: A Case Study of GLP-1 Receptor Agonist Semaglutide in Plasma

We present new data demonstrating a comprehensive and streamlined approach to optimized LC-MS/MS quantification of peptides, addressing the common challenges.

A Case Study of GLP-1 Receptor Agonist Semaglutide in Plasma

Gain insights into how delay columns, essential to control the presence of PFAS in the laboratory, function. And understand how different delay columns impact method performance.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: Landon Wiest, PhD (Product Manager - LCMS, Shimadzu Scientific Instruments)Dr. Landon Wiest is the Product Manager for LCMS at Shimadzu Scientific Instruments, leading a team of scientists who focus on applications development customer care. He has extensive experience in method and product development, research project management, and customer applications, with a strong background in liquid chromatography. At Restek Corporation, Landon led technology development teams and advanced new particle technologies, while also publishing application notes and creating educational content for webinars and short courses.He earned a Ph.D. in Analytical Chemistry from Brigham Young University, where he developed patented diamond/carbon-based chromatographic particles. Recognized for his contributions to chromatography, Landon was nominated for the Csaba Horváth Award. Fluent in Danish and knowledgeable in German, Landon excels at communicating complex scientific concepts and is dedicated to advancing scientific knowledge. Presenter: Ruth Marfil-Vega, PhD (Sr Market Manager – Environmental, Shimadzu Scientific Instruments)Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants. Since Ruth joined Shimadzu five years ago, she has continued to work with environmental stakeholders to ensure that analytical instrumentation and workflows support their success. She earned a BSc in Chemistry from the University of Valladolid (Spain) and a PhD in Environmental Science and Engineering from the University of Cincinnati.</blockquote><h3>PFAS in Focus</h3>Welcome to PFAS in Focus, a comprehensive and exclusive webinar series sponsored by Shimadzu, covering the basics and beyond about the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in the environment.Join our experts, live or on-demand after the original air date, to demystify the challenges of PFAS analysis and gain the insights you need to:<ul><li>Manage PFAS contamination in your laboratory.</li><li>Master standardized methods for PFAS testing.</li><li>Discover new analytical workflows to maximize the performance of your LC-MS/MS for PFAS analysis.</li></ul>Who should attend:<ul><li>Environmental industry professionals and academics currently working on PFAS analysis or looking to establish the application in their labs.</li><li>Representatives from drinking and wastewater utilities.</li><li>LC–MS users from any field interested in expanding their applications to include PFAS testing.</li></ul>

Mastering PFAS Control: Transform Your Laboratory Practices

Gain insights into how delay columns, essential to control the presence of PFAS in the laboratory, function.

Update your knowledge about the essential factors of PFAS analysis to support the PFAS National Primary Drinking Water Regulation.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: Landon Wiest, PhD (Product Manager - LCMS, Shimadzu Scientific Instruments)Dr. Landon Wiest is the Product Manager for LCMS at Shimadzu Scientific Instruments, leading a team of scientists who focus on applications development customer care. He has extensive experience in method and product development, research project management, and customer applications, with a strong background in liquid chromatography. At Restek Corporation, Landon led technology development teams and advanced new particle technologies, while also publishing application notes and creating educational content for webinars and short courses.He earned a Ph.D. in Analytical Chemistry from Brigham Young University, where he developed patented diamond/carbon-based chromatographic particles. Recognized for his contributions to chromatography, Landon was nominated for the Csaba Horváth Award. Fluent in Danish and knowledgeable in German, Landon excels at communicating complex scientific concepts and is dedicated to advancing scientific knowledge. Presenter: Ruth Marfil-Vega, PhD (Sr Market Manager – Environmental, Shimadzu Scientific Instruments)Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants. Since Ruth joined Shimadzu five years ago, she has continued to work with environmental stakeholders to ensure that analytical instrumentation and workflows support their success. She earned a BSc in Chemistry from the University of Valladolid (Spain) and a PhD in Environmental Science and Engineering from the University of Cincinnati.</blockquote><h3>PFAS in Focus</h3>Welcome to PFAS in Focus, a comprehensive and exclusive webinar series sponsored by Shimadzu, covering the basics and beyond about the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in the environment.Join our experts, live or on-demand after the original air date, to demystify the challenges of PFAS analysis and gain the insights you need to:<ul><li>Manage PFAS contamination in your laboratory.</li><li>Master standardized methods for PFAS testing.</li><li>Discover new analytical workflows to maximize the performance of your LC-MS/MS for PFAS analysis.</li></ul>Who should attend:<ul><li>Environmental industry professionals and academics currently working on PFAS analysis or looking to establish the application in their labs.</li><li>Representatives from drinking and wastewater utilities.</li><li>LC–MS users from any field interested in expanding their applications to include PFAS testing.</li></ul>

Unlocking EPA Methods 537.1 & 533: Optimize Your PFAS Analysis

Update your knowledge about the essential factors of PFAS analysis to support the PFAS National Primary Drinking Water Regulation.

EPA Methods 537.1 & 533: Optimize Your PFAS Analysis

Learn how to get excellent LC-MS/MS performance for simplified PFAS analysis within the flexibility afforded by EPA method 1633.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: &nbsp;Om Shrestha (Senior Research Scientist, Shimadzu Scientific Instruments)Om Shrestha is a highly skilled and results-driven Senior Research Scientist with extensive expertise in analytical method development, optimization, and analysis. With a proven track record in delivering exceptional technical support, Om is dedicated to advancing cutting-edge analytical techniques and ensuring compliance with industry standards. In his current role as Senior Application Scientist at Shimadzu Scientific Instruments, Om specializes in PFAS analysis and method development using Shimadzu LCMS, with a comprehensive understanding of methods to support regulatory frameworks such as EPA 533, 537, and 1633. He excels in leading complex projects, troubleshooting instrumentation, and collaborating with cross-functional teams to meet customer and market demands. Presenter: Ruth Marfil-Vega, PhD (Sr Market Manager – Environmental, Shimadzu Scientific Instruments)Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants. Since Ruth joined Shimadzu five years ago, she has continued to work with environmental stakeholders to ensure that analytical instrumentation and workflows support their success. She earned a BSc in Chemistry from the University of Valladolid (Spain) and a PhD in Environmental Science and Engineering from the University of Cincinnati.</blockquote><h3>PFAS in Focus</h3>Welcome to PFAS in Focus, a comprehensive and exclusive webinar series sponsored by Shimadzu, covering the basics and beyond about the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in the environment.Join our experts, live or on-demand after the original air date, to demystify the challenges of PFAS analysis and gain the insights you need to:<ul><li>Manage PFAS contamination in your laboratory.</li><li>Master standardized methods for PFAS testing.</li><li>Discover new analytical workflows to maximize the performance of your LC-MS/MS for PFAS analysis.</li></ul>Who should attend:<ul><li>Environmental industry professionals and academics currently working on PFAS analysis or looking to establish the application in their labs.</li><li>Representatives from drinking and wastewater utilities.</li><li>LC–MS users from any field interested in expanding their applications to include PFAS testing.</li></ul>

Accelerating PFAS Detection in Complex Matrices by EPA Method 1633

Learn how to get excellent LC-MS/MS performance for simplified PFAS analysis within the flexibility afforded by EPA method 1633.

PFAS Detection in Complex Matrices by EPA Method 1633

Discover simplified standardized methods for PFAS analysis based on co-solvation as sample preparation.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: &nbsp;Om Shrestha (Senior Research Scientist, Shimadzu Scientific Instruments)Om Shrestha is a highly skilled and results-driven Senior Research Scientist with extensive expertise in analytical method development, optimization, and analysis. With a proven track record in delivering exceptional technical support, Om is dedicated to advancing cutting-edge analytical techniques and ensuring compliance with industry standards. In his current role as Senior Application Scientist at Shimadzu Scientific Instruments, Om specializes in PFAS analysis and method development using Shimadzu LCMS, with a comprehensive understanding of methods to support regulatory frameworks such as EPA 533, 537, and 1633. He excels in leading complex projects, troubleshooting instrumentation, and collaborating with cross-functional teams to meet customer and market demands. Presenter: Ruth Marfil-Vega, PhD (Sr Market Manager – Environmental, Shimadzu Scientific Instruments)Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants. Since Ruth joined Shimadzu five years ago, she has continued to work with environmental stakeholders to ensure that analytical instrumentation and workflows support their success. She earned a BSc in Chemistry from the University of Valladolid (Spain) and a PhD in Environmental Science and Engineering from the University of Cincinnati.</blockquote><h3>PFAS in Focus</h3>Welcome to PFAS in Focus, a comprehensive and exclusive webinar series sponsored by Shimadzu, covering the basics and beyond about the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in the environment.Join our experts, live or on-demand after the original air date, to demystify the challenges of PFAS analysis and gain the insights you need to:<ul><li>Manage PFAS contamination in your laboratory.</li><li>Master standardized methods for PFAS testing.</li><li>Discover new analytical workflows to maximize the performance of your LC-MS/MS for PFAS analysis.</li></ul>Who should attend:<ul><li>Environmental industry professionals and academics currently working on PFAS analysis or looking to establish the application in their labs.</li><li>Representatives from drinking and wastewater utilities.</li><li>LC–MS users from any field interested in expanding their applications to include PFAS testing.</li></ul>

ASTM D8421 and D8535: Cost Effective Methods for Rapid PFAS Testing in Wastewater and Soil

Discover simplified standardized methods for PFAS analysis based on co-solvation as sample preparation.

ASTM D8421 and D8535: PFAS Testing in Wastewater and Soil

Learn how to test nonvolatile and semi-volatile PFAS compounds in consumer products by LC-MS/MS as outlined in a method being standardized by ASTM.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: &nbsp;Om Shrestha (Senior Research Scientist, Shimadzu Scientific Instruments)Om Shrestha is a highly skilled and results-driven Senior Research Scientist with extensive expertise in analytical method development, optimization, and analysis. With a proven track record in delivering exceptional technical support, Om is dedicated to advancing cutting-edge analytical techniques and ensuring compliance with industry standards. In his current role as Senior Application Scientist at Shimadzu Scientific Instruments, Om specializes in PFAS analysis and method development using Shimadzu LCMS, with a comprehensive understanding of methods to support regulatory frameworks such as EPA 533, 537, and 1633. He excels in leading complex projects, troubleshooting instrumentation, and collaborating with cross-functional teams to meet customer and market demands. Presenter: Ruth Marfil-Vega, PhD (Sr Market Manager – Environmental, Shimadzu Scientific Instruments)Dr. Ruth Marfil-Vega has 20 years of expertise in environmental chemistry and engineering in the US and Europe. She has worked with the EPA and the utilities industry to design and execute comprehensive solutions for addressing new environmental and water quality issues, including PFAS, regulated and unregulated DBPs, and other emerging contaminants. Since Ruth joined Shimadzu five years ago, she has continued to work with environmental stakeholders to ensure that analytical instrumentation and workflows support their success. She earned a BSc in Chemistry from the University of Valladolid (Spain) and a PhD in Environmental Science and Engineering from the University of Cincinnati.</blockquote><h3>PFAS in Focus</h3>Welcome to PFAS in Focus, a comprehensive and exclusive webinar series sponsored by Shimadzu, covering the basics and beyond about the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in the environment.Join our experts, live or on-demand after the original air date, to demystify the challenges of PFAS analysis and gain the insights you need to:<ul><li>Manage PFAS contamination in your laboratory.</li><li>Master standardized methods for PFAS testing.</li><li>Discover new analytical workflows to maximize the performance of your LC-MS/MS for PFAS analysis.</li></ul>Who should attend:<ul><li>Environmental industry professionals and academics currently working on PFAS analysis or looking to establish the application in their labs.</li><li>Representatives from drinking and wastewater utilities.</li><li>LC–MS users from any field interested in expanding their applications to include PFAS testing.</li></ul>

Analyzing Consumer Products for PFAS: New Method Development

Learn how to test nonvolatile and semi-volatile PFAS compounds in consumer products by LC-MS/MS as outlined in a method being standardized by ASTM.

With the need for risk assessment and testing plans looming on the horizon, join us to learn about the challenges of low-level nitrosamine detection for both LCMS and GCMS applications.We will explore the pressing questions of coming regulation, including guidance on NDSRIs, the differing use cases of the 4 Procedures of USP &lt;1469&gt; and how Shimadzu can be your partner in creating solutions to meet these requirements.As you prepare for the August 1, 2025 deadline, whether your needs will be nitrosamine discovery with LCMS-QTOF or high-sensitivity QC monitoring with headspace GC-MS/MS, Shimadzu has the hardware and applications to help you succeed.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: Brian Domanski (Strategic Collaboration Scientist, Shimadzu Scientific Instruments)Brian has over 10 years working to provide LC and SFC solutions for Pharma, as well as experience with a wide range of chromatography techniques including RP, NP, HILIC, IEX, SEC/GPC, and IC. His focus also includes scalable Informatics and Data Integrity solutions.</blockquote>

Shimadzu: Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Join us to learn about the challenges of low-level nitrosamine detection for both LCMS and GCMS applications.

Solutions for Nitrosamine Analysis by LCMS and GCMS

Join us for our winter school dedicated to accelerating your knowledge of innovative triple quad technologies and learn the fundamentals and theory of mass spectrometry. This winter, we're offering a 30-minute webinar designed to fit into your schedule.<h5>Learn more about:</h5><ul><li>The fundamentals and theory of mass spectrometry.</li><li>The ease of getting from data to results.</li><li>Recent innovations in SCIEX instrumentation: SCIEX 7500+ system.</li></ul>Event 1: December 10, 2024 10:00 - 10:30 CETEvent 2: December 17, 2024 10:00 - 10:30 CETEvent 3: January 7, 2025 10:00 - 10:30 CET

Winter school: LC-MS essentials

Master the essentials of triple quad technology with our live webinars this winter.

Session 1:The fundamental unit of a living organism is the single cell. What are the benefits and issues with pushing towards single cell measurements? The overarching goal is to provide an understanding of why discovery based single cell analysis is important and achievable. Several example applications highlight single cell metabolites including amino acids, small bio-active neuropeptides and neurotransmitters. Metabolites in individual cells were characterized using capillary electrophoresis (CE) with MRM MS with the QqQ-MS. The sample preparation steps were performed in vial inserts in the CE system to reduce the solution requirements of the autosampler to ~2 µL. Other changes to the system include a nanointerface and a mechanically tapered capillary tip for optimized detectability. The CE-nanoESI-QqQ MS system demonstrated detection limits at the single attomole level for a range of amino acids and transmitters. We characterize a range of cells including Aplysia californica neurons, rodent neurons, transplant-quality islets, and individual endocrine cells. The combination of nanovial CE-nanoESI-QqQ MS, interface, auto sampler, and fast MRM measurements enables high-throughput, high-sensitivity, and robust metabolite analysis of single cells.Key learning objectives<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Why single cell assays provide key details</li><li style="tab-stops:list 36.0pt;">How to prepare single cells for measurements</li><li style="tab-stops:list 36.0pt;">Why CE/MS works well for single cell metabolomics</li><li style="tab-stops:list 36.0pt;">Benefits of a targeted QQQ approach</li><li style="tab-stops:list 36.0pt;">How to reduce sample volumes</li><li style="tab-stops:list 36.0pt;">On going optimization of CEMS interface</li><li style="tab-stops:list 36.0pt;">Quantify differences in metabolic levels between cells</li><li style="tab-stops:list 36.0pt;">Scientists in the life sciences, with a focus on discovery, or a need for large-scale analyses</li></ul>Who should attend?<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Discovery groups involved with identifying and quantifying biomarkers. Researchers who are sample limited.</li></ul>Session 2:Untargeted metabolomics and lipidomics have traditionally been seen as primarily academic pursuits, often dismissed in clinical research due to perceived challenges in scalability and reproducibility. However, the emergence of precision health, which relies on the concept of digital twins—comprehensive digital representations of the complete molecular content of biological specimens—necessitates the use of untargeted approaches. These methods, in theory, offer the potential to explore an extensive chemical space. But what does it take to implement such analyses on a large scale, aiming both for accuracy in quantification and extensive identification? This presentation will highlight the key lessons learned from the Swiss Personalized Health Initiative.Key learning objectives<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Why is QTOF technology ideally suited for untargeted analyses, both for metabolites and lipidomics</li><li style="tab-stops:list 36.0pt;">What are the critical factors to perform large scale LC-MS (LC, MS, DDA)</li><li style="tab-stops:list 36.0pt;">Harmonization of large-scale data</li></ul>Who should attend?<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Scientists in the life sciences, with a focus on discovery, or a need for large-scale analyses</li></ul>Certificate of attendance All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.<blockquote>Presenter: Dr. Jonathan V. SweedlerJames R. Eiszner Family Endowed Professor of Chemistry and is affiliated with the Institute of Genomic Biology and the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign, University of Illinois Urbana-ChampaignDr. Sweedler’s research interests focus on developing new lipidomics, metabolomics and peptidomics approaches for assaying small volume samples including new sampling approaches, miniaturized separations, and mass spectrometry. He has used these tools to characterize small molecules and peptides in a range of animal models across metazoan life and in samples as small as individual cells and cellular domains. Sweedler has published more than 500 manuscripts and presented more than 600 invited lectures. &nbsp;He has received numerous awards including the Instrumentation Award from the Analytical Division of the ACS, the Pittsburgh Analytical Chemistry Award, and the ACS Award in Analytical Chemistry. He is a fellow of both the American Association for the Advancement of Science and the American Chemical Society. He is currently the Editor-in-Chief for Analytical Chemistry.Presenter: Prof. Dr. Nicola ZamboniProfessor at the Institute of Molecular Systems Biology of ETH Zurich, and head of the PHRT Clinical Metabolomics Analysis Center., ETH ZurichNicola Zamboni’s research pivots on investigating metabolism and its regulation, from cells to humans. The lab relies heavily on mass spectrometry to quantify levels and rates of conversion of metabolites. In parallel, it develops computational approaches to enable large-scale data acquisition and integration. The lab is embedded in the Swiss personalized health initiatives as main provider of metabolomics and lipidomics for clinical research.Moderator: Matilde Marques (Life Sciences Assistant Editor, SelectScience)</blockquote>

SelectScience: Metabolomics Masterclass: Cutting-Edge Techniques for Single Cell Analysis and Precision Health at Scale

Metabolomics Masterclass: Cutting-Edge Techniques for Single Cell Analysis and Precision Health at Scale

In two sessions, single-cell metabolomics and untargeted metabolomics, and lipidomics will be discussed.

Metabolomics Masterclass: Single Cell Analysis

LC-MS/MS is the gold standard for a wide range of analytical methods in clinical laboratories, with its orthogonality providing powerful levels of selectivity and analytical sensitivity. The Waters Total Solution LC-MS/MS Workflow has been designed to improve the user experience of LC-MS/MS to allow more users to successfully utilize the technique in their laboratories. The workflow can be adopted for a range of small molecules, as well as large molecules, such as the large glycoprotein, thyroglobulin.Using thyroglobulin as an example, we will guide you through aspects of large molecule method development and highlight steps of the workflow that minimize user touch-time, maximize throughput and improve turnaround time. Aspects of the workflow include:<ul><li>Improving the workflow reproducibility with full automation of the Stable Isotope Standards and Capture with Anti-Peptide Antibodies (SISCAPA™) approach using the&nbsp;Andrew+ Pipetting Robot</li><li>Increasing throughput and robustness with Parallel Column Regeneration</li><li>Same day reporting of results using the power of UPLC-MS/MS with waters_connect for IVD and Quan Review</li></ul>Who Should Attend?<ul><li>Laboratory professionals and clinicians who are eager to learn about the benefits of LC-MS/MS in the clinical laboratory workflow</li><li>Laboratory professionals who are seeking to expand their knowledge into using LC-MS/MS for the quantitative analysis of peptides and proteins for clinical research</li></ul><div><div dir=""><div><blockquote><div>Presenter: Dominic Foley (Consulting Scientist, Waters Corporation)</div></blockquote></div></div></div><div><blockquote>Dominic Foley is a Consulting Scientist working at Waters MS Headquarters in Wilmslow, UK. Having joined the company in September 2013, he has specialized in the development of LC-MS/MS clinical research applications, with a focus in endocrinology, particularly steroid hormone analysis. In his role, he also collaborates with clinical customers in the development and implementation of LC-MS/MS methods in their laboratories.Dominic has worked in separation sciences for 17 years, following his ambition of improving the quality of healthcare. He started his career with ICON Development Solutions, a CRO in the north of the UK, where he worked as a LC-MS/MS method development and validation scientist supporting DMPK studies in drug discovery. In 2012, he joined Thermo Fisher Scientific to work in their Chromatography R&amp;D team as a Technical Support Specialist, working on the development of new chromatography and sample preparation products.Dominic received his BSc (Hons) in Biochemistry from the University of Manchester in 2006. He has presented his work at conferences around the world and has publications in journals such as Clinical Chemistry and Laboratory Medicine, Analytical Chemistry and Journal of Chromatography A.</blockquote></div>

Waters Corporation: Quantification of Thyroglobulin in Serum for Clinical Research using SISCAPA Workflow Combined with LC-MS/MS

Quantification of Thyroglobulin in Serum for Clinical Research using SISCAPA Workflow Combined with LC-MS/MS

We will guide you through aspects of large molecule method development and highlight steps of the workflow that minimize user touch-time, maximize throughput.

LCMS webinars focusing on LC/QQQ | LabRulez LCMS