Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 30th September 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Shimadzu, Thermo Fisher Scientific, Waters Corporation, and Metrohm and a tech nical note by Agilent Technologies!<h4>1. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_openlab_oligo_analysis_accelerator_5994_7798en_agilent_d8503d3d3c.pdf">Purity, Assay, and Impurity Profiling of Single-Stranded Oligonucleotides Using Agilent Oligo Analysis Accelerator for OpenLab CDS</a></h4><ul><li>Technical note</li></ul>IntroductionChallenges with therapeutic synthetic oligonucleotides include determining the sample purity, label claim or assay, and quantitation of impurities. Traditional HPLC methods that rely on 260 nm UV detection may not have the necessary sensitivity or specificity for quality control (QC) testing. Using a more selective detector such as a mass spectrometer is a viable approach for QC testing needs. Although LC/MS methods are a mainstay for characterization of oligos, many high-resolution accurate mass detectors may not have the robustness needed in a routine testing environment such as QC. Additionally, a high level of technical expertise is often required for MS operation, data analysis, and data interpretation.A more practical approach uses a single quadrupole detector that is both sufficiently selective and sensitive enough for purity, assay, and impurity profiling of oligos. Given its relatively high mass range and sensitivity in full scan mode, the Agilent InfinityLab LC/MSD XT can meet the demands for LC/MS QC.As demonstrated by Rentel et al.,1 the LC/MSD XT can be used and validated for the QC lot release of oligos. However, one challenge that remains is the complex, multistep data analysis which requires the extraction of several extracted ion chromatograms and manual integrations. Performing these operations in a chromatography data system (CDS) while meeting compliance requirements can be time consuming. Manual transcriptions by the analyst may lead to a high margin of error, further delaying decision making.This technical overview will address the Oligo Analysis Accelerator (OAA) for Agilent OpenLab CDS. This software add-on acts as the data analysis front end to OpenLab CDS, leveraging built-in technical controls that help meet data integrity and compliance requirements. By performing overlays, integrations, and calculations in a fit-for-purpose user interface, data analysis is significantly streamlined. This not only saves time-on-task but also improves data quality.SummaryThe final step in the workflow is to review the results. This includes the SST results shown in previous steps, as well as purity and identity results. Assay results may vary depending on which formulation was selected for the sample.It is important to note that the summary itself is not the report. An OpenLab CDS report template must still be used to report the results for review. Further, any electronic signatures and approvals occur within OpenLab CDS, not in OAA. Again, this is because OAA leverages the already existing data compliance engine within the OpenLab CDS platform.Future considerationsLC/MS data analytical workflows have been confined to data systems either used to interpret spectra or chromatograms. However, the need for more user-friendly, fit-for-purpose data analysis is becoming increasingly important for the development of complex therapeutics such as oligonucleotides.&nbsp;Agilent Oligo Analysis Accelerator for OpenLab CDS is a paradigm shift in the way software is being developed.<h4>2. Waters Corporation: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008495_en_8ac74493e3.pdf">Repeatability and Reproducibility of the Oasis™ WAX/GCB for PFAS Analysis Cartridges in Aqueous Samples for EPA Method 1633</a></h4><ul><li>Application</li></ul>AbstractIn January 2024, EPA Method 1633 was finalized. EPA Method 1633 is the first method to incorporate the determination of 40 PFAS compounds across many challenging environmental sample matrices outside of drinking water, including non-potable waters (ground water, surface water, and wastewater) as well as soil, biosolids, and tissue by LC-MS/MS analysis. EPA Method 1633 requires use of both weak anion exchange (WAX) solid phase extraction with graphitized carbon black (GCB) cleanup and is a performance-based method allowing for modifications as long as acceptance criteria for recoveries and %RSDs are met.This application note highlights the sample extraction for non-potable aqueous samples in EPA Method 1633 using a dual-phase, or bilayer cartridge: Oasis WAX/GCB for PFAS Analysis meeting the method acceptance criteria and displays reproducibility of the cartridges.Benefits<ul><li>Oasis WAX/GCB for PFAS Analysis, a dual-phase cartridge is reproducible and repeatable for EPA Method 1633 aqueous samples in both inter- and intra-batch assays</li><li>Reduction of manual steps, overall sample preparation time by use of the dual-phase SPE cartridge</li><li>Acceptance criteria for recoveries and %RSDs are met for EPA Method 1633 for aqueous samples</li></ul>ConclusionThis study demonstrates the reproducibility of the dual-phase Oasis WAX/GCB for PFAS Analysis cartridges for determination of 40 PFAS and standards using the ACQUITY UPLC I-Class System and Xevo TQ-XS Mass Spectrometer. The cartridges are suitable for PFAS analysis in accordance with EPA 1633 guidelines for recovery and %RSD. The WAX/GCB cartridges show excellent repeatability across multiple product lots and within multiple replicates of each lot across non-potable water samples. The data demonstrates Oasis WAX/GCB for PFAS Analysis cartridges are ideally suited for PFAS analysis from complex matrices, such as non-potable waters like those described in EPA Method 1633. Out of the box performance is expected lot to lot and within a lot for SPE when using Oasis WAX/GCB for PFAS Analysis.<h4>3. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ab_003164_en_dllme_triplus_pfas_15478b8469.pdf">Dispersive liquid-liquid micro-extraction for the automated sample preparation of PFAS in drinking water</a></h4><ul><li>Application</li></ul>Application benefits<ul><li>Improved sensitivity: DLLME provides high enrichment factors, which can improve the detection sensitivity of PFAS in drinking water samples, down to challenging regulatory detection and reporting limits.</li><li>Cost-effective: DLLME uses a small volume of solvent, which not only reduces the cost but also makes the method more environmentally friendly.</li><li>Versatility: DLLME can be employed for the analysis of a wide range of PFAS classes, followed by either high performance liquid chromatography or gas chromatography as a separation technique, coupled to tandem mass spectrometry or high-resolution accurate mass as detection method.</li></ul>GoalTo demonstrate a comprehensive method for the analysis of per- and polyfluoroalkyl substances (PFAS) by harnessing the potential of automated sample preparation on the Thermo Scientific™ TriPlus™ RSH SMART liquid handling station, with dispersive liquid-liquid micro extraction (DLLME) as a simple, cost-effective, and versatile extraction and pre-concentration technique. This was performed on LC-MS, but the same workflow can be also applied to GC-MS.Keywords: DLLME, PFAS, sample preparation, automation, liquid handling, drinking waterConclusionsThe DLLME method presented in this work is a promising technique for the extraction and pre-concentration of PFAS from drinking water samples. Thanks to the described careful optimization and validation of the method, it provides an automated, fast, efficient, and green alternative to traditional and manual extraction methods. As compared to SPE procedures, the only manual steps consist in adding internal standards and an acidic solution to the sample, and then the TriPlus RSH SMART instrument will perform the extraction automatically, while for SPE procedures, the rest of the steps are mostly manual. This workflow allows laboratories to overcome the challenges associated with this analysis, providing high enrichment factors for all the different compound classes studied, as well as good reproducibility and robustness of the extraction process. In summary, the presented automated DLLME sample preparation has the following advantages:<ul><li>Reduced sample volume (15 mL) for easy sample handling, transportation, and storage.</li><li>Cost reduced by low solvent usage and no need for filters or SPE cartridges.</li><li>Automation enables reproducible and accurate results, with low inner- and cross-contamination.</li><li>Short runtime and automated process managed by Chromeleon software saves time and allows staff to perform more profitable activities.</li><li>The short runtime of the TriPlus RSH SMART instrument opens the possibility to feed one or more analytical instruments, including HPLC-MS or GC-MS technologies.</li><li>The extraction protocol without using filters and based on the use of low-density solvent for extraction can open the way for the extraction of other matrices such as wastewater.</li></ul><h4>4. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00658_en_79d68e6421.pdf">Efficient Data Analysis with Peakintelligence - Application for Analyzing Per- and Polyfluoroalkyl Substances (PFAS)</a></h4><ul><li>Application</li></ul>User Benefits<ul><li>Peakintelligence peak integration software substantially reduces the time and effort required for data analysis in PFAS analysis.</li><li>Since it does not require parameter settings, Peakintelligence allows even inexperienced users to perform peak integration and achieve results on par with experienced workers.</li></ul>IntroductionPer- and polyfluoroalkyl substances (PFAS) are lyophobic, heat resistant, and chemically resistant compounds used extensively as coatings, surface treatment agents, emulsifiers, and fire-extinguishing agents. Concerns about PFAS and their persistence in the environment, accumulation in living organisms, toxicity to living organisms, and ability to travel long distances have recently led to fact-finding studies on PFAS and the introduction of regulations. As of October 2023, only three PFAS are subject to regulatory restrictions in Japan (PFOS, PFOA, and PFHxS), but more are subject to restrictions in the USA and Europe. Throughout the world, an increasing number of PFAS are expected to require analysis. These changes will create more analytical data that will have to be processed, creating a need for more efficient methods of data analysis.Peakintelligence is a peak integration software equipped with peak-finding algorithms that have been developed with the help of artificial intelligence (AI). This Application News describes a case example in which it was used to process chromatogram data of PFAS analysis and reduce the effort required and increase the efficiency of the analysis.ConclusionUsing Peakintelligence to process peaks in PFAS analysis substantially reduced the number of false detections and falsely identified peaks. It also significantly reduced the number of peaks that required manual processing, and it did not need pre-analysis adjustment of parameters. These improvements enable substantial reductions in the time and effort required to perform data analysis. Avoiding parameter settings by the user also eliminates variability in the results between users, which helps eliminate dependency on specific personnel. As the number of PFAS requiring analysis increases throughout the world, a more efficient method of analyzing peaks will be needed; Peakintelligence is an effective solution for this need.<h4>5. Metrohm: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_v_239_download_6884b899af.pdf">Iron speciation in LiFePO4 batteries</a></h4><ul><li>Application</li></ul><h5>Simultaneous determination of Fe(II) and Fe(III) in lithium iron phosphate with the Multi-Mode Electrode pro</h5>Lithium iron phosphate (also known as LiFePO4 or lfp) batteries last for over 2000 charges and are safer because of their lower risk of overheating. LiFePO4 batteries have a slightly lower energy density compared to lithium-ion batteries. However, high discharge rates of lfp batteries make them ideal for electric vehicles, renewable energy storage, and backup power systems. Lithium iron(II) phosphate is used as a cathode material in lithium iron phosphate batteries. Characterization of lfp and monitoring the oxidation state of iron in lfp batteries is relevant to battery performance in terms of durability, capacity, and safety. Additionally, analyzing chemical composition can be useful for battery research and can aid eco-friendly recycling practices. This is essential for driving battery technology forward and promoting clean energy solutions.Polarographic speciation of Fe(II) and Fe(III) can be used to evaluate the purity of LiFePO4 and its usability as a cathode material in lithium iron phosphate batteries. It can further be used to study the concentrations of Fe(II) and Fe(III) in the cathode material after several charging and discharging cycles to evaluate the aging behavior.

News from LabRulezLCMS Library - Week 40, 2024

What chemicals are we exposed to on a daily basis? That is the central question of ‘non-targeted analysis’ or NTA, an emerging field of analytical science that aims to identify all chemicals around us. A daunting task, because how can you be sure to detect everything if you don’t know exactly what you’re looking for? In a paper in Environmental Science and Technology, researchers at the Universities of Amsterdam (UvA, the Netherlands) and Queensland (UQ, Australia) assess this problem. In a meta-analysis of NTA results published over the past six years, they estimate that less than 2% of all chemicals have been identified.According to Viktoriia Turkina who performed the research as a PhD student with Dr Saer Samanipour&nbsp; at the UvA’s Van ‘t Hoff Institute for Molecular Sciences, this limitation underscores the urgent need for a more proactive approach to chemical monitoring and management. “We need to incorporate more data-driven strategies into our studies to be able to effectively protect the human and environmental health”, she says.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Viktoriia_Turkina_de5a1652e1.jpg" alt="University of Amsterdam / HIMS: Viktoriia Turkina." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Viktoriia_Turkina_de5a1652e1.jpg 164w," sizes="100vw" width="700" height="665">Samanipour explains that current monitoring of chemicals is rather limited since it’s expensive, time consuming, and requires specialized experts. “As an example, in the Netherlands we have one of the most sophisticated monitoring programs for chemicals known to be of concern to human health. Yet we target less than 1000 chemicals. There are far more chemicals out there that we don't know about.”<h4>A vast chemical space</h4>To deal with those chemicals, some 15 to 20 years ago the concept of non-targeted analysis was introduced to look at possible exposure in an unbiased manner. The idea is to take a sample from the environment (air, water, soil, sewer sludge) or the human body (hair, blood, etc ) and analyse it using well-established analytical techniques such as chromatography coupled with high resolution mass spectroscopy. The challenge then is to trace the obtained signal back to the structures of chemicals that may be present in the sample. This will include already known&nbsp; chemicals, but also chemicals of which the potential presence in the environment is yet unknown.In theory, this ‘chemical space’ includes as many as 1060 compounds, an incomprehensible number that exceeds the number of stars in the universe by far. On the other hand, the number of organic and inorganic substances published in the scientific literature and public databases is estimated at around 180 million. To make their research even more manageable, Turkina, Samanipour and co-workers focused on a subset of 60.000 well-described compounds from the NORMAN database. Turkina: “This served as the reference to establish what is covered in NTA studies, and more importantly, to develop an idea about what is being overlooked.”<blockquote>The vast ‘exposome’ of chemicals that humans are exposed to on a daily basis is a sign of our times, according to Samanipour. “These days we are soaking in a giant ocean of chemicals. The chemical industry is part of that, but also nature is running all a whole bunch of reactions that result in exposure. And we expose ourselves to chemicals by the stuff we use - think for instance of the problem of microplastics. To solve all this we have to be able to go beyond pointing fingers. With our research, we hope to contribute to finding a solution together. Because we all are in the same boat.”</blockquote><div><div><div><div><h4>Much room for improvement</h4>The meta analysis, which included 57 NTA papers, revealed that only around 2% of the estimated chemical space was covered. This can indicate that the actual exposure to chemicals is indeed quite low, however, it can also point to shortcomings in the applied analyses. According to Turkina and Samanipour, the latter is indeed the case. They focused on NTA studies applying liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) -one of the most comprehensive methods for the analysis of complex environmental and biological samples.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Saer_Samanipour_5c78a79b5b.jpg" alt="University of Amsterdam / HIMS: Saer Samanipour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Saer_Samanipour_5c78a79b5b.jpg 180w," sizes="100vw" width="700" height="606"><div>It turned out that there was much room for improvement. For instance in sample preparation, they observed a bias towards specific compounds rather than capturing a more diverse set of chemicals. They also observed poor selection and inconsistent reporting of LC-HRMS parameters and data acquisition methods. “In general”, Samanipour says, “the chemical analysis community is to a great extent driven by the available technology that vendors have developed for specific analysis purposes. Thus the instrumental set-up and data processing methods are rather limited when it comes to non-targeted analysis.”To Samanipour, the NTA approach is definitely worth pursuing. “But we need to develop it further and push it forward. Together with vendors we can develop new powerful and more versatile analytical technologies, as well as effective data analysis protocols.” He also advocates a data-driven approach were the theoretical chemical space is ‘back calculated’&nbsp; towards a subset of chemicals that are highly likely to be present in our environment. “Basically we have to better understand what is the true chemical space of exposure. And once those boundaries are defined, then it becomes a lot easier to assess that number of 2% we have determined.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_EST_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Distribution_of_all_chemicals_found_in_the_reviewed_articles_orange_overlaid_on_top_6a16bff0b0.jpg" alt="University of Amsterdam / HIMS / EST: Distribution of all chemicals found in the reviewed articles (orange), overlaid on top." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_EST_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Distribution_of_all_chemicals_found_in_the_reviewed_articles_orange_overlaid_on_top_6a16bff0b0.jpg 245w," sizes="100vw" width="777" height="441"></div></div></div></div></div>

There is much to improve in identifying all the chemicals around us 

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University of Amsterdam

Agilent Technologies

Thermo Fisher Scientific

Waters Corporation

How to avoid potential non-compliance with regulatory guidelines in challenging times.
The complexities of maintaining compliance and audit-readiness in regulated environments take significant time and resources. Learn in this part of the session how to mitigate the risk of potential non-compliances as you return to the lab or transition instrumentation to meet new demands with operational qualification and requalification services from Unity Lab Services. See how you can save time and improve your laboratory’s performance. 
<h3>Learn about:</h3>
<ul>
<li>Qualification Services for Analytical Instruments and Laboratory Equipment </li>
<li>Range of qualification capabilities that provide improved productivity, single-vendor convenience, a no-charge requalification guarantee</li>
</ul>
<blockquote>
Presenter: Martin Wheeler (Regulatory Product Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Martin has worked since 1997 within the organization focusing on single quadrupole instrumentation using Gas &amp; Liquid Chromatography together with Mass Spectrometers, CDS and Layered Applications. His current role as Regulatory Product Manager includes compliance and qualification procedures working closely as part of the Regulatory Product Support Group assisting Field based Engineers, as well as creating/updating qualification protocols.
</blockquote>
<blockquote>
Presenter: Julian Renpenning - Moderator (Regional Marketing Manager EMEA, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Julian studied at the Technical University of Berlin Biotechnology and specialized in analytical chemistry and bioprocess engineering. In 2011 he started his PhD at the Environmental Research in Leipzig, Germany and continued in 2015 to work as Postdoc career on analytical method development for hyphenated MS, IRMS and ICP-MS with gas chromatography. Since 2019 I took a role at TFS as EMEA Regional Marketing Manager for GC, GC-MS and IOMS.
</blockquote>

Thermo Fisher Scientific - Webinars Live and on-demand

Moving forward webinar part 3 - compliance

During this webinar we will showcase how engaging with a single service provider for all laboratory maintenance will unburden your organization.
<blockquote>
Presenter: Charles van Dortmond (European Enterprise Services Engagement Manager, Agilent Technologies)
</blockquote>
<blockquote>
Charles has worked in the Laboratory industry for 30+ years, first as manager in a high-throughput contract laboratory and later transitioning into several commercial roles in Laboratory Informatics. He rejoined Agilent in 2017 as European Enterprise Services Engagement Manager. Charles is part of the EMEAI Laboratory Productivity Specialists team and responsible for driving cross-border sales activities.
</blockquote>

Agilent Technologies: How Agilent's Managed Services will unburden your Organization

Advance Your Lab Operation: How Agilent's Managed Services will unburden your Organization

Changes to Regulatory requirements around Analytical Instrument Qualification (AIQ) have resulted in more responsibility for end-users of instruments to define and implement customized qualification solutions based on their specific User Requirements, Intended Use and Range of Use. Continuing to use Service Vendors &quot;Standard&quot; protocols presents increased Compliance Risk as this will alert Regulatory Inspectors that you are not qualifying your instruments based on your Intended Use.
<blockquote>
Presenter: Garry Wright (European Laboratory Compliance Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Garry Wright is the European Laboratory Compliance Specialist for Agilent Technologies and a member of Agilent&#39;s Compliance Council. Garry has over 20 years of experience working in Regulated Pharmaceutical Industry prior to joining Agilent in 2015. During this time he has been involved in the development and implementation of Quality Management Systems (QMS), GxP Training and Auditing. Garry&#39;s role within Agilent as a Compliance Specialist is to help develop Agilent products and services from a compliance perspective and assist Agilent customers with compliance challenges they face in their laboratory environments. Garry regularly presents on topics including Regulatory Compliance, Analytical Instrument Qualification and Data Integrity.
</blockquote>

Agilent Technologies: Minimize Regulatory Risk by Moving to a Customized Instrument Qualification Solution

Advance Your Lab Operation: Minimize Regulatory Risk by Moving to a Customized Instrument Qualification Solution

During this webinar we will run through the real challenges that customers face when performing CSV and how Agilent has helped customers by linking their needs to the capabilities of the application being validated. We will also look at how Agilent&#39;s compliance consulting services and the continuous improvement of our own starter kits can reduce the time and burden CSV causes to the customer.
<blockquote>
Greg Shaw (European Compliance Consultant, Agilent Technologies)
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Greg has been working at Agilent for 1 ½ years, prior to Agilent he spent 14 years working in the Pharma Industry and GMP environments. During his time working in Pharma, he spent 10 years performing Computerized System Validation activities on Enterprise and standalone computerised systems and worked on a number of Data Integrity remediation projects. he also has experience with FDA local regulatory and customer audits.
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When he joint Agilent, he initially worked in the IES EMEAI team performing Enterprise OpenLab CDS Installations and ACE qualifications.
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He is currently working in the European Compliance Consulting team managing compliance consulting projects focused on Computerized System Validation (GAMP 5 methodology) and Data Integrity assessment/remediation. He works with the Global Senior Compliance Consultant to provide customer specific compliance services to meet the customer&#39;s requirements which include: Computerized System Validation, Audits/Assessments, custom AIQ procedure development, and Data Integrity assessments and remediation.
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<blockquote>
Thérèse Heffernan (European Compliance Consultant, Agilent Technologies)
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Thérèse Heffernan is a European Compliance Consultant for Agilent Technologies and a member of Agilent&#39;s Compliance Council. Therese has 20 years of experience working in Regulated Pharmaceutical Industry prior to joining Agilent in 2019. During this time she has been involved in managing compliance consulting projects focused on Computerized System Validation (GAMP 5 methodology) and in the development and delivery of Agilents new CSV Starter Kits. She works with the Global Senior Compliance Consultant to provide customer specific compliance services to meet the customer&#39;s requirements which include: Computerized System Validation, Audits/Assessments, custom AIQ procedure development, and Data Integrity assessments and remediation.
</blockquote>

Agilent Technologies: Real Life Challenges and Solutuins seen with CSV Projects

Advance Your Lab Operation: Real Life Challenges and Solutuins seen with CSV Projects

Having access to instrument utilization data is a key part in creating a maintenance strategy for the laboratory. But the value of utilization data extends beyond maintenance and operations, this webinar will show you value streams accross all elements of an instruments lifecycle.
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Greg Stevens (Digital Services Specialist, Agilent Technologies)
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Greg Stevens is a data strategist and works with Agilent customers across the region in pursuit of providing solutions that improve business outcomes that harness the use of data.
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Greg comes from a background of Asset &amp; Program Management and has worked across varied business sectors, serving organisations both as an employee and independent consultant.
</blockquote>

Agilent Technologies: Why instrument utilization data is critical in your asset lifecycle strategy

Advance Your Lab Operation: Why instrument utilization data is critical in your asset lifecycle strategy

The pharma industry is undergoing constant evolution, requiring implementation of more efficient process while experiencing more stringent regulatory requirements.
The ability to be fast to market, while maintaining a strong understanding of your product, is critical.
At Agilent, we understand your analytical requirements.
<h3>Thursday, 18th February - Live Broadcast</h3>
<h5>1. 10:15 a.m. – 11:15 a.m. CET The fundamentals of dissolution</h5>
<blockquote>
Presenter: Owain McKenzie (EMEA Dissolution Business Team Manager, Agilent Technologies)
</blockquote>
<h5>2. 12:00 p.m. – 01:00 p.m. CET Minimize Regulatory Risk by moving to a Customized Instrument Qualification Solution</h5>
<blockquote>
Presenter: Garry Wright (European Laboratory Compliance Specialist, Agilent Technologies)
</blockquote>
<h5>3. 03:00 p.m. – 04:00 p.m. CET Dissolution best practices and qualification</h5>
<blockquote>
Presenter: Owain McKenzie (EMEA Dissolution Business Team Manager, Agilent Technologies)
</blockquote>

Agilent Technologies: Agilent 1st Pharma Virtual Symposium

Agilent Pharma Virtual Symposium - Day 2

More and more companies are choosing to look toward financing options as opposed to capital expenditure to fund their laboratory purchases. We discuss the benefits of this approach.​
<blockquote>
Presenter: Richard Styles (Director of Leasing EMEAI, Waters)
</blockquote>
<blockquote>
Richard has been with Waters for 5 years developing innovative, tailor made finance solutions for our customers. He has over 30 years of domestic and international experience through management roles at bank based and manufacturer captive leasing companies.​
</blockquote>

StartupStockPhotos: Waters Corporation - Meet the Experts Webinars

Meet the Experts - Part 1 - Alternative Procurement Strategies

Introducing Waters FlexCHOICE which offers personalized, flexible support, maintenance, and service options.
With FlexCHOICE, you can select mySystem Coverage and customize your system-level services and support, while maintaining the performance you have come to trust from Waters.​
The presentation will focus on three main aspects of how you can access service and support from Waters.
<ul>
<li>Overview of the latest online support resources and tools - self-help knowledge base, how-to videos, educational resources etc.
</li>
<li>How to connect remotely to Waters technical support Expert Centres and use of remote and augmented reality technology.
</li>
<li>Latest development in Waters flexible On-Site Service options - learn how you can build your best-fit service coverage.
</li>
</ul>
<blockquote>
Presenter: Andy Billingsley (Service Marketing Manager Europe, Waters Corporation)
</blockquote>
<blockquote>
Andy has been at Waters for over 30 years (he says he joined aged 4) in technical chromatography and software-based roles in Northern Europe.​
</blockquote>
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Prior to joining Waters Andy worked in the pharmaceutical industry in the field of Neuroscience Research.​
</blockquote>
<blockquote>
He obtained a degree in Biochemistry from the University of Liverpool.​
</blockquote>

LCMS webinars focusing on Services | LabRulez LCMS

Meet the Experts - Part 2 - Flexible Service and Support Plans