Author
Watrex Praha
Watrex Praha
WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.
Tags
Article
Product
LinkedIn Logo

Nuts are only half of… Ferrule that’s doing most of the work

Th, 27.3.2025
| Original article from: Watrex Praha
While the nut provides the driving force for compression, it’s the ferrule that compresses against the tubing and thus holds the tubing in place.
<p><strong>Watrex:</strong> Nuts are only half of… Ferrule that’s doing most of the work!</p>

Watrex: Nuts are only half of… Ferrule that’s doing most of the work!

Ferrules aren’t nearly as complicated as their nut counterparts, but they do have some distinguishing features to help you determine which ones to use. One thing they have in common is their tapered noses…and it’s at the end of this nose where ferrules do what they were designed to do — grip the tubing wall!

When selecting the correct fitting for a given application, the following should be considered:

  • tubing size
  • pressure requirements
  • mating nut
  • receiving port geometry – most important
Watrex: Picture 1: Different between ferrule configurations.Watrex: Picture 1: Different between ferrule configurations.

Generally, low pressure receiving ports end in a flat-bottom configuration. The ferrules used with this type of port will typically have their tapered noses facing toward the nut and away from the flat bottom of the receiving port.

High pressure receiving ports have an internal taper just past the threaded portion of the port. Then, just beyond the internal taper is a small pocket — often called the “tubing pocket” — which is nearly the same diameter as the tubing that extends into it. In these types of ports, the tapered nose of the ferrule faces away from the nut and toward the port.

“Tapered noses face the port when pressures are high but they face the nut when low pressures apply!”

One very important characteristic of any ferrule is the material from which it is made. Ferrules are often manufactured from materials such as stainless steel, PEEK, ETFE, polypropylene and PCTFE. Materials such as PEEK polymer (a beige-colored plastic), PCTFE, and stainless steel are often used to manufacture ferrules for high pressure applications. Softer polymers, including ETFE and polypropylene, are used primarily (although not solely) in lower-pressure applications. You can find all variants in our product range.

Browse the HPLC consumables catalogs from our suppliers IDEX, VICI and Optimize Technologies and choose the best for you and your systems!

Still unsure which nut and ferrule combination to choose? Contact us at [email protected] or visit our website www.watrex.com and we will be happy to advise you!

Watrex Praha
LinkedIn Logo
 

Related content

Oligonucleotide Analysis Using the Agilent InfinityLab Pro iQ and Altura Oligo HPH-C18 Column

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/SQ, Consumables, LC columns
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Simultaneous Quantitation and Discovery analysis: Combining targeted and untargeted metabolomics on Orbitrap mass spectrometers

Applications
| 2026 | Thermo Fisher Scientific
Instrumentation
LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS
Manufacturer
Thermo Fisher Scientific
Industries
Metabolomics

Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Wastewater

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

Non-Targeted Screening of Biosolids with the Xevo™ MRT Mass Spectrometer Reveals New Isoforms of PFAS

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Waters
Industries
Environmental

High Resolution Characterization of Lipid Nanoparticles Using the Xevo™ Charge Detection Mass Spectrometry (CDMS) Instrument - Single Particle Mass Analysis of Intact LNP-mRNA Formulations

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/HRMS, Particle characterization, LC/IT
Manufacturer
Waters
Industries
Lipidomics
 

Related articles

Automated SW solution for preparative HPLC
Article | Product

Automated SW solution for preparative HPLC

Application examples of Clarity software for analytical and small scale preparative separation using multivendor analytical and preparative HPLC components.
DataApex
tag
share
more
4 things you should know about the chromatography nuts!
Article | Product

4 things you should know about the chromatography nuts!

Every chromatographer knows that selecting the right fitting components is essential for the smooth operation of an HPLC system.
Watrex Praha
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
Single-Ended HPLC Column by SIELC
Article | Product

Single-Ended HPLC Column by SIELC

SIELC introduces a single-ended HPLC column that eliminates fittings, dead volume, and leaks. Discover a new connection standard that simplifies installation, improves reliability, and streamlines LC workflows.
Bioanalytic
tag
share
more
 

Related content

Oligonucleotide Analysis Using the Agilent InfinityLab Pro iQ and Altura Oligo HPH-C18 Column

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/SQ, Consumables, LC columns
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Simultaneous Quantitation and Discovery analysis: Combining targeted and untargeted metabolomics on Orbitrap mass spectrometers

Applications
| 2026 | Thermo Fisher Scientific
Instrumentation
LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS
Manufacturer
Thermo Fisher Scientific
Industries
Metabolomics

Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Wastewater

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

Non-Targeted Screening of Biosolids with the Xevo™ MRT Mass Spectrometer Reveals New Isoforms of PFAS

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Waters
Industries
Environmental

High Resolution Characterization of Lipid Nanoparticles Using the Xevo™ Charge Detection Mass Spectrometry (CDMS) Instrument - Single Particle Mass Analysis of Intact LNP-mRNA Formulations

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/HRMS, Particle characterization, LC/IT
Manufacturer
Waters
Industries
Lipidomics
 

Related articles

Automated SW solution for preparative HPLC
Article | Product

Automated SW solution for preparative HPLC

Application examples of Clarity software for analytical and small scale preparative separation using multivendor analytical and preparative HPLC components.
DataApex
tag
share
more
4 things you should know about the chromatography nuts!
Article | Product

4 things you should know about the chromatography nuts!

Every chromatographer knows that selecting the right fitting components is essential for the smooth operation of an HPLC system.
Watrex Praha
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
Single-Ended HPLC Column by SIELC
Article | Product

Single-Ended HPLC Column by SIELC

SIELC introduces a single-ended HPLC column that eliminates fittings, dead volume, and leaks. Discover a new connection standard that simplifies installation, improves reliability, and streamlines LC workflows.
Bioanalytic
tag
share
more
 

Related content

Oligonucleotide Analysis Using the Agilent InfinityLab Pro iQ and Altura Oligo HPH-C18 Column

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/SQ, Consumables, LC columns
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Simultaneous Quantitation and Discovery analysis: Combining targeted and untargeted metabolomics on Orbitrap mass spectrometers

Applications
| 2026 | Thermo Fisher Scientific
Instrumentation
LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS
Manufacturer
Thermo Fisher Scientific
Industries
Metabolomics

Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Wastewater

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

Non-Targeted Screening of Biosolids with the Xevo™ MRT Mass Spectrometer Reveals New Isoforms of PFAS

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Waters
Industries
Environmental

High Resolution Characterization of Lipid Nanoparticles Using the Xevo™ Charge Detection Mass Spectrometry (CDMS) Instrument - Single Particle Mass Analysis of Intact LNP-mRNA Formulations

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/HRMS, Particle characterization, LC/IT
Manufacturer
Waters
Industries
Lipidomics
 

Related articles

Automated SW solution for preparative HPLC
Article | Product

Automated SW solution for preparative HPLC

Application examples of Clarity software for analytical and small scale preparative separation using multivendor analytical and preparative HPLC components.
DataApex
tag
share
more
4 things you should know about the chromatography nuts!
Article | Product

4 things you should know about the chromatography nuts!

Every chromatographer knows that selecting the right fitting components is essential for the smooth operation of an HPLC system.
Watrex Praha
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
Single-Ended HPLC Column by SIELC
Article | Product

Single-Ended HPLC Column by SIELC

SIELC introduces a single-ended HPLC column that eliminates fittings, dead volume, and leaks. Discover a new connection standard that simplifies installation, improves reliability, and streamlines LC workflows.
Bioanalytic
tag
share
more
 

Related content

Oligonucleotide Analysis Using the Agilent InfinityLab Pro iQ and Altura Oligo HPH-C18 Column

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/SQ, Consumables, LC columns
Manufacturer
Agilent Technologies
Industries
Pharma & Biopharma

Simultaneous Quantitation and Discovery analysis: Combining targeted and untargeted metabolomics on Orbitrap mass spectrometers

Applications
| 2026 | Thermo Fisher Scientific
Instrumentation
LC/MS, LC/MS/MS, LC/Orbitrap, LC/HRMS
Manufacturer
Thermo Fisher Scientific
Industries
Metabolomics

Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Wastewater

Applications
| 2026 | Agilent Technologies
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

Non-Targeted Screening of Biosolids with the Xevo™ MRT Mass Spectrometer Reveals New Isoforms of PFAS

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/TOF, LC/HRMS
Manufacturer
Waters
Industries
Environmental

High Resolution Characterization of Lipid Nanoparticles Using the Xevo™ Charge Detection Mass Spectrometry (CDMS) Instrument - Single Particle Mass Analysis of Intact LNP-mRNA Formulations

Applications
| 2026 | Waters
Instrumentation
LC/MS, LC/MS/MS, LC/HRMS, Particle characterization, LC/IT
Manufacturer
Waters
Industries
Lipidomics
 

Related articles

Automated SW solution for preparative HPLC
Article | Product

Automated SW solution for preparative HPLC

Application examples of Clarity software for analytical and small scale preparative separation using multivendor analytical and preparative HPLC components.
DataApex
tag
share
more
4 things you should know about the chromatography nuts!
Article | Product

4 things you should know about the chromatography nuts!

Every chromatographer knows that selecting the right fitting components is essential for the smooth operation of an HPLC system.
Watrex Praha
tag
share
more
News from LabRulezLCMS Library - Week 10, 2026
Article | Application

News from LabRulezLCMS Library - Week 10, 2026

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!
LabRulez
tag
share
more
Single-Ended HPLC Column by SIELC
Article | Product

Single-Ended HPLC Column by SIELC

SIELC introduces a single-ended HPLC column that eliminates fittings, dead volume, and leaks. Discover a new connection standard that simplifies installation, improves reliability, and streamlines LC workflows.
Bioanalytic
tag
share
more
Other projects
GCMS
ICPMS
Follow us
FacebookX (Twitter)LinkedInYouTube
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike