Quantification of Gd species in a tetrameric Gd-based contrast agent using HPLC-ICP-MS
This study presents an HPLC-ICP-MS method for precise quantification of Gd complexes in Gadoquatrane, enabling detection of trace by-products to optimize synthesis and drug control strategies.
Mo, 17.3.2025
LabRulez
Scientific article | Science and research
Evaluating the potential of hydrophilic interaction liquid chromatography for collagen peptide mapping analysis
This study optimizes a HILIC method for collagen peptide mapping, evaluating stationary phases, injection techniques, and MS coupling to enhance peptide separation and hydroxylation analysis.
Mo, 17.3.2025
LabRulez
Article | Application
News from LabRulezLCMS Library - Week 11, 2025
This week we bring you application notes by Agilent Technologies, Knauer, Shimadzu, Thermo Fisher Scientific and Waters Corporation!
High-throughput mercury speciation analysis of breast milk using HPLC-ICP-MS
This study developed an HPLC-ICP-MS method to quantify Hg²⁺ and MeHg⁺ in breast milk, evaluating collection methods, total mercury correlation, and elemental associations in samples over a 4-month study.
Mo, 10.3.2025
LabRulez
Scientific article | Various
Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography
This study investigates how mobile phases and chromatographic conditions affect siRNA duplex stability, using DSC and chromatography to measure melting temperatures.
Mo, 10.3.2025
LabRulez
Article | Application
News from LabRulezLCMS Library - Week 10, 2025
This week we bring you application notes and other documents by Agilent Technologies, Knauer, Mestrelab, Shimadzu, Thermo Fisher Scientific and Waters Corporation!
We, 5.3.2025
LabRulez
Article | Webinars
Webinars LabRulezLCMS Week 10/2025
This week 4 webinars: Bioprocessing Monitor App, Released Glycan Analysis, Monitoring Your HPLC Method, Biomarker Breakdown.
Mo, 3.3.2025
LabRulez
Scientific article | Various
Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography
This study identifies ion release from borosilicate glass bottles as a cause of poor HILIC retention time repeatability and proposes PFA bottles as a solution.