My name is James Little and my private consulting company is Mass Spec Interpretation Services. I contract for NIST, Wiley, and Sapec. Previously, I was a Research Fellow specializing in mass spectrometry at Eastman Chemical Company in Kingsport, TN and retired in early 2016 after &gt;37 years of service. For 2017-2019, I did NMR as a limited service employee specializing in end group determinations for Eastman.
My main interest is the identification of organic compounds by mass spectrometry in organic mixtures. All the technical information on my web page was approved as technical session handouts, conference presentations, workshops, journal publications, courses, etc. for distribution outside Eastman. Other postings on this site are my own and do not necessarily represent Eastman’s positions, strategies or opinions. I also include a “little” information about my sailing experiences.
In 2017, I purchased a used Model S85 Tesla and starting to participate in electric vehicle events. In addition, I am a member of the choir at St. Paul’s Episcopal Church, play competitive duplicate bridge, and race sailboats on Watauga Lake.

James Little - Mass Spec Interpretation Services

Retired Organic Mass Spectrometrist, Research Fellow, for Eastman Chemical Company, currently privately owned Mass Spec Interpretation Services.

Over the years we have gained knowledge and experience to provide laboratory of chromatography solutions in the next areas: environmental, petrochemical, chemical, food &amp; flavour, life sciences and forensics.
<h3>Knowledge partner</h3>
Since 2002 JSB has been active on the European market and in the past ten years JSB positioned itself as a full knowledge partner in chromatography and mass spectrometry solutions. Analytical instruments can be purchased in different places, but solid advice tailored to the needs of your laboratory or process environment is not readily available. However, you can call on JSB for both GC (MS) and LC (MS) techniques specifically for your field of application. We have a full range of custom-made solutions. We consider it our task to offer added value when it comes to instrumentation. These standard or custom-made solutions are often delivered including application. For sample pre-processing to full automation, JSB ensures a turnkey solution of several systems, together with the relevant application.
<h3>Inspiration meets innovation</h3>
Your problem is our inspiration, which often results in innovative solutions. JSB presents itself to its customers as a knowledge partner in chromatography. We think very highly of both knowledge and innovation. JSB produces the solution for you in their workshop if no commercial solution is available. That is how JSB always wants to be one step ahead of knowledge. This is also possible because JSB invests in the knowledge and skill of highly-trained staff. Therefore, you can be absolutely sure that JSB is the knowledge partner you have been looking for. Our capital is invested in our employees who can support you in terms of instrumental technique, applications, service and maintenance, automation and specific software solutions.
<h3>Custom-made systems</h3>
Being the largest regional Value Added Reseller for Agilent Technologies, JSB bases its systems on the GC (MS) and LC (MS) modules of Agilent Technologies. Together with the large variety of sample pre-processing and detection equipment from several partners such as AFP, CTC, CDS, EST, IonSensev, Owlstone, SAI, SIM and Zoex, JSB offers a full range of analysers and accessories. By means of our own research and development department solutions can be combined, modified or developed.
<h3>Consumer goods</h3>
JSB is also your partner for consumer goods such as columns and glass work, including application support. Besides the complete catalogue of Agilent Technologies JSB also offers other brands such as AFP, Hamilton, ILS, LCTech, Restek, SGE, Tosoh and Valco Vici. 
<h3>Getting acquainted</h3>
Are you looking for a specific application? Or do you want advice about a technical problem? Please feel free to contact one of our specialists.

JSB International

Over the years we have gained knowledge and experience to provide laboratory of chromatography solutions in the next areas: environmental, petrochemical, chemical, food & flavour, life sciences and forensics.

HPLC a LC/MS servisní technik Ing. Jiří Luňák (HPLC servis)

I am a graduate of the University of Chemistry and Technology in Pardubice in the department of analytical chemistry. I have been involved in chromatography since the beginning of my professional career. For the last 26 years, I was working for Waters Corporation in the service department until my departure in 2023. As a service technician, I gained experience in laboratories all over the Czech Republic. Thanks to many years of experience, I can also offer knowledge from older instrumentation, whose official support has already ended. In addition to basic services, I can provide maintenance of chromatography systems, their confirmation and qualification.
<h3>Service support of Waters HPLC a LCMS</h3>
<h4>1. On-site Service of HPLC and LC/MS</h4>
Performed the diagnostics, repair and testing after repair.
<h4>2. Performance Maintenance of HPLC and LC/MS</h4>
The condition evaluation of the chromatography system by performing targeted tests. Proposal for partial or complete maintenance according to the manufacturer&#39;s recommendations. Performed tests after maintenance.
<h4>3. HPLC and LC/MS systems confirmation, calibration</h4>
At the beginning is basic testing of the individual modules of the chromatography system. After that, if necessary or according to request, the maintenance is performed. The required parameters are calibrated. This is followed by tests verifying the basic characteristics of the accuracy and reproducibility of the system and is evalueted as to whether they meet the specification. Certified chemicals and calibrated tools are used to confirm the system.
<h4>4. Installation and commissioning of older HPLC and LC/MS systems</h4>
In the case of older used chromatographic instruments, their condition is evaluated. If necessary, then their repair, maintenance, or addition of missing components will be proposed. Confirmatory tests including accuracy and reproducibility evaluation characteristics are used for verification. After complete installation and documentation of test results, operator training is carried out. This can be followed by the preparation of the system for targeted application and, in cooperation with application support, the development and optimization of the chromatographic method.
<h4>5. HPLC and LC/MS systems qualification</h4>
To successfully complete all qualification tests, the system must be in good condition. Therefore, at the beginning, its condition is verified by evaluating its condition since the last maintenance. The maintenance and other tests are performed, such as pressure tests, checking the sensitivity of the detectors, MS charging test, etc. If necessary or according to a previous order, repair/maintenance is performed. During the qualification process, all the necessary parameters are verified, which are then evaluated.
Both the parameters of individual modules (OQ) and the entire system are qualified. Certified chemicals and calibrated tools are used for the system qualification. The customer supplies only the mobile phase.
<h4>6. Instruments and software operation training of Waters HPLC and LCMS</h4>
The training is provided according to the customer&#39;s needs and request.

Ing. Jiří Luňák (HPLC service)

Self-employed technician providing service and support of LC and MS instruments manufactured by Waters Corporation.

As a global provider of analytical technology, Waters&nbsp;makes scientific ambitions a reality through the application of liquid chromatography, mass spectrometry and thermal analysis instruments, consumables, and informatics as well as industry-leading scientific expertise.With more than 7,400 employees worldwide, Waters operates in 35 countries, including 14 manufacturing facilities, with products available in more than 100 countries.The European Headquarter is located in Saint-Quentin En Yvelines Cedex (part of the Paris metropolitan area), France.<h5>Subsidiaries in Europe in following countries:</h5><ul><li>Austria</li><li>Belgium</li><li>Czech Republic</li><li>Denmark</li><li>Germany</li><li>Finland</li><li>France</li><li>Hungary</li><li>Ireland</li><li>Italy</li><li>Netherlands</li><li>Norway</li><li>Poland</li><li>Portugal</li><li>Spain</li><li>Sweden</li><li>United Kingdom</li></ul>

Waters Corporation (Europe)

Waters makes scientific ambitions a reality through the application of HPLC, MS and TA instruments, consumables, and informatics as well as industry-leading scientific expertise.

KNAUER manufactures high-end&nbsp;scientific instruments for research, routine analysis, quality assurance, and other applications. Supported technologies include liquid chromatography, precise handling and pumping of liquids up to high pressures, as well as flow-through detection of dissolved substances. Customizable products and solutions are one of our strengths. Made in Germany. Developing devices that help people in the laboratory to gain new insights or facilitate their work. This is the spirit in which KNAUER was founded and continues to drive the company today.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_We_love_HPLC_More_than_7000_products_5cc7d96a6b.jpg" alt="KNAUER: We love HPLC. More than 7000 products." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_We_love_HPLC_More_than_7000_products_5cc7d96a6b.jpg 204w," sizes="100vw" width="1121" height="859"><h3>We separate molecules and unite people.</h3>As experts in liquid chromatography, we continue the path of our founder Dr. Knauer: Together with scientists and other experts in the lab we develop innovative and individual solutions. We are curious and creative. This makes us the ideal partner for those wanting more than a standard solution.KNAUER is an established partner in science. We support research and technological advancement today and in the future.<ul><li>Family business since 1962</li><li>Based in Berlin, Germany</li><li>About 190 employees</li><li>More than 7000 products</li></ul>At KNAUER "We love HPLC" and we work for "Science with Passion" ... and we are an established partner in science. Today and in the future.<blockquote>“To provide simpler solutions than our competitors – that was a success factor at the beginning.“Dr.-Ing. Herbert Knauer, Founder</blockquote>It all started with a soldering iron, a jigsaw and an ingenious idea for a highly accurate electronic thermometer. Chemist Dr.-Ing. Herbert Knauer founded the company together with his wife Roswitha in 1962.&nbsp;The couple‘s daughter, Alexandra Knauer, is managing director and owner of the company since the year 2000,&nbsp;and on April 1, 2021, the previous head of worldwide sales, Carsten Losch, was appointed as a second managing director. Today, KNAUER is an established company with about 190 employees that successfully develops, manufactures and markets chromatography instruments worldwide.<figure class="image"><img style="aspect-ratio:1600/1067;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Alexandra_Knauer_CEO_and_owner_of_KNAUER_c6bfeb28eb.jpg" alt="KNAUER: Alexandra Knauer (CEO and owner of KNAUER)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Alexandra_Knauer_CEO_and_owner_of_KNAUER_c6bfeb28eb.jpg 235w," sizes="100vw" width="1600" height="1067"></figure><h4>KNAUER lives sustainability</h4>Not only because we are scientists, but also we care - about the environment, animals and our future. KNAUER has many initiatives for a greener company. For example, plastic beverage bottles have been banned from the company, and coming to work by bike or public transport is rewarded.<h4>Our vision until 2025</h4><ul><li>We provide tools that enable science to gain knowledge and contribute to the health and well-being of humanity and the planet.</li><li>We are pioneers for sustainability and work together in a trustful and result-oriented way.</li><li>We remain an independent high-tech producer with LC products for laboratory and production, and we are open to new technologies if they sustainably improve our work processes.</li><li>Our customers from various industries are at the center of everything we do. We develop, produce and adapt solutions in best quality.</li></ul><h4>Corporate Social Responsibility</h4>We are engaged in the well-being of our employees and take responsibility for our environment and the conservation of nature. Our social responsibility is reflected in our Corporate Social Responsibility (CSR) activities.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_company_headquarters_8ad9fb868b.jpg" alt="KNAUER: Company headquarters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_company_headquarters_8ad9fb868b.jpg 235w," sizes="100vw" width="1600" height="1067"><h4>Your career at KNAUER</h4>You are committed to your work, you strive to be responsible for your own actions, you are creative and eager to put your ideas into practice? We should get to know you!At KNAUER, we offer you an attractive work environment, flat hierarchies and a wide scope of opportunities. Our engagement for our employees is award-winning. We are proud to have won prizes for being one of the best employers among German medium-sized businesses, Berlin's most family-friendly company and one of the most innovative companies in Germany.Are you looking for a company where you can do an apprenticeship, an internship, or which offers topics for a bachelor or master thesis? We are looking forward to receiving your application!<h4>Innovation is recognized</h4>KNAUER won numerous awards for innovations and entrepreneurial excellence.

KNAUER

KNAUER manufactures high-end scientific instruments for research, routine analysis, quality assurance, and other applications.

<h5>The main objectives of our association are:</h5>
<ul>
<li>to support and carry out education in the field of separation science</li>
<li>to promote and disseminate separation science to both, scientific and general public with an emphasis on young generation</li>
<li>to search for new applications of separation science</li>
<li>to organize <a href="https://lcms.cz/companies/216">a conference HPLC.cz</a> in Czech Republic</li>
</ul>
Education in the field of separation science is carried out through scientific seminars, workshops, practical training, and scientific conferences. Since 2008, the Czech Chromatographic School has organized seven scientific conferences which were well attended by both academics and by members of the industry. The last two conference events attracted more than 150 participants.
Furthermore, the Czech Chromatographic School cooperates with a wide spectrum of vendors in the form of scientific seminars and training. The most successful event is a regular two-day practical training in HPLC in collaboration with Pragolab.

Czech Chromatographic School

The Czech Chromatographic School is a non-profit private scientific association. It aims at bringing together supporters and users of analytical chemistry, especially its chromatographic methods. 

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Czech Republic

You will be joining the dynamic Lipidomics Group at the University of Pardubice, working on high-impact research funded by prestigious grants:<ol><li>ERC Advanced grant “Oncolipidomics: Why is lipidomic dysregulation pattern in blood similar for various cancers? (ONCOLIPID)”</li><li>OP JAK grant “Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors (SALVAGE)”</li></ol><h3>Two Postdoctoral Positions in Lipidomics and Glycomics</h3><ul><li>Start Date: January 2025 (or as soon as possible)</li><li>Duration: 12 months, with a possibility of extension until the end of the project (August 2028)</li><li>Location: Lipidomics Group of Prof. Michal Holčapek, University of Pardubice, Faculty of Chemical Technology, Department of Analytical Chemistry, Czech Republic</li><li>Salary: Competitive, based on university guidelines, and commensurate with experience and skills.</li></ul><h3>1. Lipidomics Postdoc</h3>You will be involved in the complete lipidomic analysis workflow, including:<ul><li>Sample preparation using established extraction protocols.</li><li>Ultrahigh-performance liquid chromatography - mass spectrometry (UHPLC/MS).</li><li>Data processing using LipidQuant software.</li><li>Advanced statistical evaluation using multivariate analysis tools (e.g., Simca, R-scripts).</li></ul>This role offers hands-on experience with state-of-the-art instrumentation and in-depth exposure to lipidomics applied to cancer biomarker discovery.<h3>2. Glycomics Postdoc</h3>You will focus on the glycomic analysis of glycans enzymatically released from glycosphingolipids, including:<ul><li>Sample preparation including enzymatic cleavage of glycans.</li><li>UHPLC/MS.</li><li>Identification of glycan sequences from MS/MS spectra, retention behavior, and ion mobility data, and quantitation.</li><li>Advanced statistical evaluation using multivariate analysis tools (e.g., Simca, R-scripts).</li></ul>This position offers the opportunity to innovate in data processing workflows and contribute to cutting-edge glycomics research.<h4>Requirements for Both Positions</h4><ul><li>Ph.D. in (bio)analytical chemistry or a closely related field.</li><li>Proficiency in mass spectrometry and liquid chromatography.</li><li>Strong passion for scientific research, reliability, and the ability to work collaboratively in a dynamic team.</li></ul><h4>Preferred but not required:</h4><ul><li>Experience in lipidomic, metabolomic, or glycomic analysis.</li><li>Familiarity with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=38">supercritical fluid chromatography-mass spectrometry</a>.</li><li>Experience with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=8&amp;search=TIMS-TOF">TIMS-TOF (Bruker)</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=29-31-30-32&amp;mainauthorItems=5">QTOF (Waters)</a>, or QQQ (<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=35-32-31&amp;mainauthorItems=55">Sciex</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=35-32-31&amp;mainauthorItems=10">Agilent</a>) instruments.</li><li>Knowledge of software tools for metabolomics/lipidomics (e.g., MZmine, Skyline).</li></ul><h4>About the Lipidomics Research Group</h4>Our group is an international, collaborative team of over 15 postdoctoral researchers and students. We offer a supportive and intellectually stimulating environment, with access to cutting-edge technology. We specialize in lipidomics and metabolomics by mass spectrometry, focusing on cancer biomarker discovery. Our patented methodology for the early detection of pancreatic and other cancers is currently being translated into clinical applications through our spin-off company, <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/articles?search=Lipidica">Lipidica</a>.&nbsp;We provide comprehensive training in lipidomic techniques to all new members, including hands-on experience with the latest instruments and software.<h4>Our Research Facilities</h4><ul><li>Mass Spectrometers: timsTOF Ultra (Bruker), QTOF Synapt G2Si (Waters), QTOF Xevo G2-XS (Waters), QTOF micrOTOF-QII (Bruker), MALDI LTQ Orbitrap XL (Thermo), 6500 QTRAP (Sciex), QqQ 6495D (Agilent), and Xevo TQD (Waters).</li><li>Chromatographs: 2x ultrahigh-performance supercritical fluid chromatograph Waters ACQUITY UPC2 system (Waters), ACQUITY Premier UPLC Bioinert System (Waters), 2x UHPLC Agilent 1290 Infinity series (Agilent), and UHPLC Agilent 1290 Infinity II Bio (Agilent).</li><li>Laboratory Equipment: Microbiological Safety Cabinet Mars Class II (LaboGene), Microbiological Safety Cabinet Class II MSC-Advantage™ Class II (ThermoFisher), Lab freezers (Arctiko and ThermoFisher), Homogenizer Combo Precellys Evolution + Cryolys Evolution (Bertin), etc.</li><li>Data Processing Software: MarkerLynx (Waters), LipidQuant (our software), LipidView (Sciex), Simca (Umetrics), MetaboScape and TASQ ® Software (Bruker), etc.</li></ul><h4>How to Apply</h4>If you are enthusiastic about joining a world-class research team, please send the following documents:1. A motivation letter detailing your research interests and why you want to join our group.2. Your CV, including a description of your skills and relevant experience.Candidates with strong experimental skills in mass spectrometry and chromatography will be prioritized. Shortlisted candidates will be invited to a Zoom interview.&nbsp;Note: The position remains open until filled. Early applications are encouraged.<a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/articles?search=Michal+Hol%C4%8Dapek">Prof. Michal Holčapek, Ph.D.</a>University of Pardubice Faculty of Chemical Technology, Department of Analytical Chemistry Studentska 573, 53210 Pardubice, Czech Republic Phone: +420 466 037 087 Email: <a href="mailto:Michal.Holcapek@upce.cz">Michal.Holcapek@upce.cz</a> <a target="_blank" rel="noopener noreferrer" href="http://holcapek.upce.cz/">http://holcapek.upce.cz/</a><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::article.article/Univerzita-Pardubice-Michal-Holcapek.jpg" alt="Univerzita Pardubice: Prof. Michal Holčapek, Ph.D." width="null" height="null">

Postdoctoral Positions in Lipidomics and Glycomics

As the world leader in serving science, our work is more than something that fills our days – what we do has great purpose. Our industry-leading scale means unparalleled commercial reach, unique customer access and a global footprint. Our broad customer base, from research to clinical to commercial production means you can have a broad and meaningful impact here at Thermo Fisher Scientific. All while working in an environment where you will be supported, valued and rewarded for your performance.<h3>Field Service Engineer III (IOMS)(MA REMOTE)</h3><div><div><div><section><div><div><div><div><div>Unity Lab Services, a part of Thermo Fisher Scientific, provides integrated solutions, instrument, and enterprise services to our customers.&nbsp;&nbsp; The Engineer III Field Service Engineer is responsible for handling all aspects of field service support and customer relationship management including but not limited to: installation, repair, preventative maintenance, and instrument qualification.&nbsp; The Engineer III Field Service Engineer will be customer oriented, an advocate for Thermo Fisher Scientific, and eager to drive growth. &nbsp;&nbsp;<h4>Essential Duties and Responsibilities:</h4><ul><li>Perform on-site installation, repair, preventative maintenance, and qualification of <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/search/results?query=Mass%20Spectrometry&amp;focusarea=Search%20All">IOMS</a> Spectroscopy instrumentation</li><li>Must be customer-focused, working in conjunction with Professional Services and outsourcing functions.</li><li>Must be proficient with the use of customer management software to track service calls, manage parts inventories, and complete job tasks.</li><li>Reviews reports and documentation from customers, and inspects malfunctioning product to resolve nature and scope of problem.</li><li>Analyzes review and inspection findings to resolve source of problem, and recommends repair, replacement, or other corrective action.</li><li>Coordinates problem resolution with engineering, customer service, and other personnel to expedite repairs.</li><li>Analyzes instrument generated chemistry and performance reports of technical issues to recommend factory modifications that eliminate future events of the same issue.</li><li>Provides a communication link between the customer and the company to help ensure that effective service is provided to the customer.</li><li>Develops and conducts training on the safe operations of the equipment and demonstrates skills to trainees, including both team members and customers (Chemists).</li><li>Show and demonstrate progression in training and certification for advanced products.</li><li>Other duties may be assigned.</li></ul><h4>Minimum Education and/or Experience Requirements:</h4><ul><li>Bachelor’s degree in chemistry, Sciences or related field preferred</li><li>3+ years hands-on experience as a Service Engineer is helpful, particularly <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/search/results?query=Mass%20Spectrometry&amp;focusarea=Search%20All">Inorganic Mass Spectrometry</a> instrumentation</li><li>Hands-on experience with <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/search/results?query=Mass%20Spectrometry&amp;focusarea=Search%20All">IOMS</a>, High-Resolution MA, <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/isotope-ratio-mass-spectrometry-irms/gas-isotope-ratio-mass-spectrometry-irms.html">GIRMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/search/results?query=DFS&amp;focusarea=Search%20All">DFS</a>&nbsp;instrumentation strongly preferred</li><li>Effective interpersonal skills and establishing good customer rapport are important</li><li>Ability to prioritize service requests and produce clear and concise documentation</li></ul><h4>Physical Work Requirements:</h4><ul><li>Must be available to travel daily, and up to 80% overnight</li><li>Must be able to lift 40 lbs, stand for long periods of time, and willing to work overtime.</li><li>Valid Driver’s License Required, and be able to travel into DOE, DOD and National Laboratories</li><li>Able to successfully pass federal background checks</li></ul></div></div></div></div></div></section></div></div></div><h4>Work Schedule</h4><ul><li>First Shift (Days)</li></ul><h4>Environmental Conditions</h4><ul><li>Adherence to all Good Manufacturing Practices (GMP) Safety Standards</li></ul>

Field Service Engineer III (IOMS)(MA REMOTE)

Masaryk University is modern, dynamic and the most attractive university in the Czech Republic with ten faculties, more than 6500 staff and 33 000 students, a wide range of research areas and a strong international position. We are the largest academic employer in the South Moravian Region.Faculty of Science MU, a holder of the HR Excellence in Research Award by the European Commission, is a research-oriented faculty, offering university education (Bachelor’s, Master’s, and Doctoral degree programs) closely linked to both primary and applied research and high school teaching of the following sciences: Mathematics, Physics, Chemistry, Biology, and Earth sciences. We are the most productive scientific unit of the Masaryk University generating around 40 % of MU research results.RECETOX&nbsp; focuses on interdisciplinary research and education in the area of Environment &amp; Health, studying toxic compounds and their behavior, transport &amp; bioaccumulation to evaluate environmental effects, assess the exposure and health risks to humans, and develop technologies and biotechnologies to break them down.Bursar of the Faculty of Science, Masaryk University announces an open competition for the position:<h3>POSTDOCTORAL POSITION IN BIOMEDICAL PROTEIN RESEARCH AND ENGINEERING</h3><h4>Job Description</h4>Are you passionate about proteins and biomedical innovations?Join our dynamic, interdisciplinary research team tackling both fundamental and translational challenges in protein engineering. We investigate enzyme molecular mechanisms and pioneer innovative therapies for Alzheimer’s disease and acute stroke.<ul><li><a target="_blank" rel="noopener noreferrer" href="https://loschmidt.chemi.muni.cz/peg/">WEB</a></li><li><a target="_blank" rel="noopener noreferrer" href="http://www.youtube.com/watch?v=FJa9ov-gofM&amp;t=122s">MOVIE</a></li></ul><h4>Key duties</h4><ul><li>Investigate enzyme mechanisms and clinically significant proteins</li><li>Conduct structural and functional analyses using advanced biophysical techniques</li><li>Perform in-depth data analysis with state-of-the-art computational tools</li><li>Take an active role in experimental design, execution, and data interpretation</li><li>Gain valuable experience mentoring students and presenting at international events</li></ul><h4>Skills and Qualifications</h4><ul><li>Ph.D. in biochemistry, molecular biology, biophysics or a related discipline</li><li>Proven experience with protein expression, purification and characterization</li><li>Interest in cutting-edge biophysical methods, e.g., FIDA, mass photometry, SPR</li><li>Self-motivated, well-organized, collaborative, and creatively driven</li></ul><blockquote>Informal inquiries about the position can be sent to: Šárka Nevolová, email: nevolova@sci.muni.cz.</blockquote><h4>We Offer</h4><ul><li>A collaborative, multidisciplinary, and international research environment</li><li>Ambitious biomedical projects with strong clinical impact</li><li>Access to cutting-edge instruments and advanced computational resources</li><li>Opportunities for professional development and long-term career growth</li><li>An interesting job in a dynamically-expanding university area</li><li>Flexible working hours and occasional home office to support personal needs in family and career compatibility</li><li>Employee benefits such as 6 weeks of paid vacation per year, pension insurance contribution or nursery/children´s group allowance, a financial meal allowance, lunches in canteens of MU, Multisport card, vaccinations free of charge, discounted language courses, exclusive mobile tariff offer by Vodafone, childcare groups at Campus and Komenského náměstí</li><li>Opportunity to work and live in a modern and dynamic city (for more information on costs of living, you can refer to Numbeo)</li><li>Welcome Office provides support with your relocation to Brno</li></ul><h4>Application Process</h4>The application shall be submitted online by 31.07.2025 via an e-application, please find the reference to the e-application in the beginning and end of the advertisement.The candidate shall provide following:<ul><li>CV</li><li>Cover letter</li><li>Two letters of recommendation</li></ul>After submitting your application successfully, you will receive an automatic confirmation email from jobs.muni.cz. In case of problems with filling in the e-application form, please contact us by e-mail: rcx-hr@recetox.muni.cz.<h4>Selection Process</h4>Received applications will be considered carefully in line with <a target="_blank" rel="noopener noreferrer" href="https://euraxess.ec.europa.eu/sites/default/files/brochures/am509774cee_en_e4.pdf">principles of the EU Charter and Code for Researchers</a>. Selection criteria: (i) meeting qualification requirements described above, (ii) all required documents provided.Shortlisted candidates will be invited for a personal or online interview.We are looking forward to hearing from you!

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