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Application Note Rapid Analysis of Lipid Nanoparticle Components Using BioAccord LC-MS System Giorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. Plumb Waters Corporation Abstract The recent success of mRNA vaccines for COVID-19 is in part…
Key words
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Rapid Analysis and Characterization of Lipid Nanoparticle Components for mRNA Delivery W0930-09-49 Giorgis Isaac, Nilini Ranbaduge, Suraj Dhungana Waters Corporation, 34 Maple Street, Milford, Massachusetts, USA CONTACT INFORMATION: [email protected] PURPOSE Success of mRNA vaccines for SARS-CoV-2 highlight the potential of…
Key words
lipid, lipidnanoparticle, nanoparticlelnp, lnpmrna, mrnacomponents, componentscharacterization, characterizationfour, fourbinary, binarydspc, dspcplot, plotpegylated, pegylatedimpurities, impuritiesquick, quickassociated, associatedanalysis
Rapid Analysis of Lipid Nanoparticle Components Using BioAccord™ LC-MS System Giorgis Isaac, Nilini Ranbaduge, Colette Quinn, Weibin Chen and Robert S. Plumb Waters Corporation, Milford, MA Introduction ▪ The recent success of mRNA vaccines in SARSCoV-2 clinical trials is in…
Key words
lnp, lnplipid, lipidbioaccord, bioaccordnanoparticle, nanoparticledspc, dspcmrna, mrnabinary, binaryspectroscopically, spectroscopicallydelivery, deliverycomponents, componentspegylated, pegylatedsilent, silentacquity, acquityanalysis, analysisattack
Analysis of Lipid Nanoparticle Composition
2022|Agilent Technologies|Applications
Application Note Biopharma Analysis of Lipid Nanoparticle Composition Author Sonja Schneider Agilent Technologies, Inc. 0 DLin-MC3-DMA DMG-PEG 2000 DSPC ×102 4.75 4.50 4.25 4.00 3.75 3.50 3.25 3.00 2.75 2.50 2.25 2.00 1.75 1.50 1.25 1.00 0.75 0.50 Cholesterol Response…
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