IMPROVING PERFORMANCE OF MULTI-ATTRUBUTE METHOD ASSAYS USING AN LC-MS WITH A NOVEL INERT FLUDIC PATHWAY | LabRulez LCMS
 

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APPLICATION NOTE 72916A high-resolution accurate mass multi-attribute method forcritical quality attribute monitoring and new peak detectionAuthorsHaichuan Liu1, Royston Quintyn2,John Rontree3Thermo Fisher Scientific1San Jose, CA2West Palm Beach, FL3Hemel Hempstead, UKKeywordsMulti-attribute method, MAM, peptidemapping, Q Exactive Plus, Orbitrap,mass spectrometry, MS, LC/MS,product quality...
Key words
intensity, intensitynistmab, nistmabmam, mamchromeleon, chromeleonpeptide, peptidestressed, stressedprtc, prtcratio, ratiothermo, thermofinder, finderscientific, scientificretention, retentioncounts, countsbiopharma, biopharmaintegration
[ BIOACCORD SYSTEM WITH ACQUITY PREMIER ]Routine BiopharmaceuticalAnalysis – AcceleratedACCESS | COMPLIANCE | QUALITY | EFFICIENCY [ BIOACCORD SYSTEM WITH ACQUITY PREMIER ]Improving lab efficiency without sacrificing results quality iscritical, but that isn’t easy. Now you can achieve high qualitydata while...
Key words
bioaccord, bioaccordpremier, premieracquity, acquitysystem, systemdata, datapennyk, pennykachieve, achievequality, qualitycompliant, compliantconventional, conventionalminimizing, minimizingmam, mamproductive, productivemetal, metalworkflows
Application NoteThe BioAccord System With ACQUITYPremier for Improved Peptide CQAMonitoringNilini Ranbaduge, Robert E. Birdsall, Ying Qing Yu, Weibin ChenWaters CorporationAbstractPeptide MAM is an LC-MS based assay for direct biotherapeutic product attribute analysis that is increasingly usedin protein biotherapeutic quality assessment....
Key words
bioaccord, bioaccordpremier, premierhps, hpsmaxpeak, maxpeaksurfaces, surfacesmam, mamacquity, acquitypeptide, peptideperformance, performanceacidic, acidicsystem, systemattribute, attributeaspartic, aspartictechnology, technologymetal
Improving Multi-Attribute Method using LC-MS System with Novel Inert Fluidic PathwayNilini Ranbaduge, Robert E Birdsall, Ying Qing Yu, Weibin Chen, Waters Corporation, Milford, MAIntroductionResultsNon-specific adsorption of acidic peptides to metal surfacesis a well-known phenomenon affecting LC-MS analyses,causing asymmetric peaks, loss...
Key words
eeqynstyr, eeqynstyrpennyk, pennykvvsvltvlhqdwlngk, vvsvltvlhqdwlngksystem, systemfluidic, fluidicbase, basesuccinimide, succinimidepeptide, peptideoxidation, oxidationmodification, modificationcqa, cqaimproved, improvedpeak, peakdeamidation, deamidationhps
 

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APPLICATION NOTE 72916A high-resolution accurate mass multi-attribute method forcritical quality attribute monitoring and new peak detectionAuthorsHaichuan Liu1, Royston Quintyn2,John Rontree3Thermo Fisher Scientific1San Jose, CA2West Palm Beach, FL3Hemel Hempstead, UKKeywordsMulti-attribute method, MAM, peptidemapping, Q Exactive Plus, Orbitrap,mass spectrometry, MS, LC/MS,product quality...
Key words
intensity, intensitynistmab, nistmabmam, mamchromeleon, chromeleonpeptide, peptidestressed, stressedprtc, prtcratio, ratiothermo, thermofinder, finderscientific, scientificretention, retentioncounts, countsbiopharma, biopharmaintegration
[ BIOACCORD SYSTEM WITH ACQUITY PREMIER ]Routine BiopharmaceuticalAnalysis – AcceleratedACCESS | COMPLIANCE | QUALITY | EFFICIENCY [ BIOACCORD SYSTEM WITH ACQUITY PREMIER ]Improving lab efficiency without sacrificing results quality iscritical, but that isn’t easy. Now you can achieve high qualitydata while...
Key words
bioaccord, bioaccordpremier, premieracquity, acquitysystem, systemdata, datapennyk, pennykachieve, achievequality, qualitycompliant, compliantconventional, conventionalminimizing, minimizingmam, mamproductive, productivemetal, metalworkflows
Application NoteThe BioAccord System With ACQUITYPremier for Improved Peptide CQAMonitoringNilini Ranbaduge, Robert E. Birdsall, Ying Qing Yu, Weibin ChenWaters CorporationAbstractPeptide MAM is an LC-MS based assay for direct biotherapeutic product attribute analysis that is increasingly usedin protein biotherapeutic quality assessment....
Key words
bioaccord, bioaccordpremier, premierhps, hpsmaxpeak, maxpeaksurfaces, surfacesmam, mamacquity, acquitypeptide, peptideperformance, performanceacidic, acidicsystem, systemattribute, attributeaspartic, aspartictechnology, technologymetal
Improving Multi-Attribute Method using LC-MS System with Novel Inert Fluidic PathwayNilini Ranbaduge, Robert E Birdsall, Ying Qing Yu, Weibin Chen, Waters Corporation, Milford, MAIntroductionResultsNon-specific adsorption of acidic peptides to metal surfacesis a well-known phenomenon affecting LC-MS analyses,causing asymmetric peaks, loss...
Key words
eeqynstyr, eeqynstyrpennyk, pennykvvsvltvlhqdwlngk, vvsvltvlhqdwlngksystem, systemfluidic, fluidicbase, basesuccinimide, succinimidepeptide, peptideoxidation, oxidationmodification, modificationcqa, cqaimproved, improvedpeak, peakdeamidation, deamidationhps
 

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