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Comprehensive Adeno-Associated Virus Critical Quality Attribute Analysis with Liquid Chromatography-Mass Spectrometry

Posters | 2021 | Agilent Technologies | ASMSInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words
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Application Note Biopharma/Pharma Adeno-Associated Virus Characterization with Agilent 6545XT AdvanceBio LC/Q-TOF and Protein Metrics Byos Software Authors Wendi A. Hale and Christopher M. Colangelo Agilent Technologies Inc. Lexington, MA, USA Michelle English Protein Metrics Cupertino, CA, USA Abstract This application…
Key words
byos, byosprotein, proteinvariant, variantpeptide, peptideiterative, iterativeaavs, aavsreconstruction, reconstructionaav, aavsva, svaxle, xlemetrics, metricsmapping, mappingintact, intactamino, aminohcp
Poster Reprint ASMS 2020 ThP 466 Purity and Identity Characterization of AdenoAssociated Virus Capsid Particles by Intact and BottomUp Based Liquid Chromatography-Mass Spectrometry Methods Wendi A. Hale1, Dominique Garceau2, Tristan Cano2, Caitlin Jaeger2, Roy Hegedus2, William Hermans2, Norman Garceau2, Christopher…
Key words
capsid, capsidviral, viralspectrum, spectrumaavs, aavsswarm, swarmcqas, cqasintact, intacttherapy, therapyptms, ptmsgene, genepeptide, peptideproteins, proteinsautotune, autotunetranslational, translationaladvancebiolc
Application Note Pharma & Biopharma Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF Authors Wendi A. Hale and Christopher M. Colangelo Agilent Technologies, Inc., Lexington, MA, USA Roy Hegedus and Norman Garceau Lake Pharma, Worcester, MA, USA…
Key words
capsid, capsidcounts, countsgene, genemass, massviral, viralpeptide, peptidecharge, chargedeconvoluted, deconvolutedadeno, adenoadvancebio, advancebiovector, vectorproteins, proteinscqas, cqasiterative, iterativetherapy
APPLICATION NOTE 000242 Adeno-associated virus capsid protein characterization and host cell protein profiling using micro-flow UHPLC-Orbitrap MS Authors: Reiko Kiyonami1, Jennifer Sutton1, Katy Irvin2, Ken Cook3, Estee Toole4, Min Du5 Thermo Fisher Scientific, San Jose, CA; 2 Thermo Fisher Scientific,…
Key words
hcp, hcpaav, aavpeptide, peptideprotein, proteinpurified, purifiedviral, viralcapsid, capsidmapping, mappingharvest, harvestmodification, modificationsetting, settingpepsin, pepsinabundant, abundanthost, hostprotease
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