Crosslinking mass spectrometry (XL-MS) goes mainstream
Technical notes | 2018 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesProteomics
ManufacturerThermo Fisher Scientific
Key wordscrosslinked, protein, peptides, crosslinking, crosslinkers, dsso, interactions, peptide, mass, can, ions, proteins, cleavable, complexes, researchers, linked, crosslink, regions, used, proteome, fragmentations, dsbu, reagents, xlinkx, sequence, reactive, distance, crosslinker, workflow, fragmentation, diagnostic, examining, generated, different, roles, has, groups, cleavage, have, cleave, two, data, interacting, techniques, tmt, chemical, proteomics, understand, crosslinks, spectrometry
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2016|Thermo Fisher Scientific|Posters
Thermo Scientific™ Proteome Discoverer™ using a XlinkX software node. Methods: Different amine-reactive, homobifuctional crosslinkers including disuccinimidyl Results: For both DSSO and BuUrBu, we identified over 40 BSA inter-crosslinked peptides 2 CID for DSSO. We also to less than(DSS), 20 using…
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ASMS: Optimization of Crosslinked Peptide Analysis on an Orbitrap Fusion Lumos Mass Spectrometer
2016|Thermo Fisher Scientific|Posters
evaluated traditional non-cleavable and MS-cleavable crosslinkers for crosslinked peptide analysis using an Orbitrap Fusion Lumos mass spectrometer. For MS-cleavable crosslinkers, we also compared different types of fragmentation (CID, ETD) and levels of tandem mass spectrometry (MS2 vs. MS3). Our data…
Key words
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ASMS: Relative Quantification of TMT-labeled, cross-linked proteins using XlinkX node in Proteome Discoverer
2018|Thermo Fisher Scientific|Posters
Relative Quantification of TMT-labeled, cross-linked proteins using XlinkX node in Proteome Discoverer Rosa Viner1, Kai Fritzemeier2, Frank Berg2, Torsten Ueckert2, Leigh Foster3, Ryan Bomgarden3, Richard A. Scheltema4, Albert J.R. Heck4, Clinton Yu5, Lan Huang5; 1Thermo Fisher Scientific, San Jose, CA;…
Key words
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New tools for improved proteomics results
2022|Thermo Fisher Scientific|Brochures and specifications
Proteomics New tools for improved proteomics results Sample preparation, quantitation, and instrument calibration reagents for proteomic mass spectrometry Introduction We offer a complete portfolio of sample preparation, protein quantitation, and instrument calibration solutions and standards designed for better mass spectrometry…
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