53rd conference synthesis and analysis of drugs 2025 - Book of Abstracts

Significance of the topic

This conference served as a premier international forum for experts in drug synthesis, medicinal chemistry, and advanced analytical methods to exchange novel findings and foster collaborations in both academic and industrial settings.

Objectives and Conference Overview

The 53rd Conference on Synthesis and Analysis of Drugs aimed to present cutting-edge research spanning three days at Congress Hotel Kurdějov. It featured invited and plenary lectures, short talks, poster sessions, sponsor and industrial presentations, and networking events. Major themes included drug design, green and flow chemistry, biocatalysis, supercritical fluid chromatography, bioanalytical imaging, and antimicrobial and anticancer agents.

Main Methodologies and Techniques

Innovative methodologies highlighted included continuous‐flow peptide synthesis with green solvents, organocatalyzed asymmetric reactions, biocatalytic C–C bond formations, and elemental labeling in ICP-MS for molecular information. Chromatographic advances covered SFC, HILIC for sugar analysis, flash and capillary electrophoresis for glycan profiling, and novel fluorescent and mass-tag labels. Imaging and detection methods such as LA-ICP-MS, LIBS, Raman optical activity, and evanescent-field sensing were showcased. Computational tools for retrosynthesis, chemometric modeling, and AI-driven drug discovery were also presented.

Key Findings and Discussion

Speakers reported improved stereoselectivities in organocatalysis, efficient flow protocols with reduced waste, and enhanced sensitivity in trace analysis of biomarkers and pollutants. Novel drug scaffolds included boron­based inhibitors, bis­indole dimers, aporphine alkaloid derivatives, polymer‐drug conjugates, and metal complexes with promising antiproliferative and antimicrobial activities. Multiplexed digital solutions and simplified workflows demonstrated potential to accelerate drug discovery and QC processes.

Practical Benefits and Applications

Advances presented promise more sustainable synthesis, higher-throughput analytics, and more reliable biomarker and impurity detection. Improved chiral separations and targeted formulations address therapeutic selectivity and bioavailability. Digital and AI platforms facilitate faster decision-making and method transfer in regulated laboratories.

Future Trends and Possibilities

The conference forecast further integration of AI and machine learning in synthesis planning, expanded use of green and continuous-flow technologies, next-generation imaging for single-cell and nano-scale analysis, and modular digital platforms for real-time data management.

Conclusion

This gathering underscored the rapid evolution of drug synthesis and analysis through multidisciplinary innovations, paving the way for safer, greener, and more effective pharmaceutical development.