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Oligonucleotide mapping using BioPharma Finder software
2020|Thermo Fischer Scientific|Applications
APPLICATION NOTE73789Oligonucleotide mapping usingBioPharma Finder softwareAuthors: Haichuan Liu1, Kevin Guo2,Jennifer Sutton1, Min Du2Thermo Fisher Scientific, San Jose, CAThermo Fisher Scientific, Boston, MA12Keywords: Oligonucleotide, DNA, RNA,data dependent acquisition, tandemmass spectrometry, LC-MS, ion pairingchromatography, IR RPApplication benefits• High resolution accurate mass mass...
Key words
pgd, pgdpad, padptd, ptdpcd, pcdoligonucleotides, oligonucleotidesptdpcd, ptdpcdoligonucleotide, oligonucleotidestepped, steppedfinder, finderpgr, pgrbiopharma, biopharmapur, purnce, nceintensity, intensitylens
An Automated Compliance-Ready LC-MS Workflow for Intact MassConfirmation and Purity Analysis of OligonucleotidesCatalin Doneanu, 1 Jonathan Fox, 2 Emma Harry, 2 Chris Knowles, 3 Ying Qing Yu,1 Joseph Fredette, 1 and Weibin Chen11Waters Corporation, Milford, MA2Waters Corporation, Wilmslow, UK3Waters Corporation,...
Key words
oligonucleotides, oligonucleotidespurity, puritycompliance, complianceintact, intactready, readyoligonucleotide, oligonucleotideconfirmation, confirmationworkflow, workflowoligo, oligoautomated, automatedmass, massnote, noteapplication, applicationacquity, acquitybioaccord
SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES VIA AUTOMATED TOP-DOWN SPECTRAL ANNOTATIONMaria Basanta-Sanchez, Catalin Doneanu, Joe Fredette, Barbara Sullivan, Weibin Chen and Iggy KassWaters Corporation, Milford, MAOVERVIEWRESULTSMETHODSSequence analysis / confirmation of full length modified and non-Materialsmodified oligonucleotides using Spectrum tools.Top-down MS/MSOligonucleotides were purchased...
Key words
rna, rnadna, dnasequence, sequenceannotation, annotationoligonucleotide, oligonucleotidedown, downtop, topmodified, modifiedcharge, chargeenergy, energycoverage, coverageoligo, oligodata, dataspectrum, spectrumspectra
[ APPLICATION NOTEBOOK ]APPLICATION SOLUTIONS FOROLIGONUCLEOTIDES Table of ContentsIntroduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4[ HPLC & UPLC Separations ]Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11Oligonucleotide Separation Technology: Synthesis Challenges and HPLC Isolation Options...
Key words
oligonucleotides, oligonucleotidesoligonucleotide, oligonucleotideuplc, uplcacquity, acquityrnai, rnaiost, ostduplex, duplexpromass, promassduplexes, duplexessirna, sirnawaters, watersqda, qdarna, rnaanalysis, analysispairing
 

Similar PDF

Toggle
Oligonucleotide mapping using BioPharma Finder software
2020|Thermo Fischer Scientific|Applications
APPLICATION NOTE73789Oligonucleotide mapping usingBioPharma Finder softwareAuthors: Haichuan Liu1, Kevin Guo2,Jennifer Sutton1, Min Du2Thermo Fisher Scientific, San Jose, CAThermo Fisher Scientific, Boston, MA12Keywords: Oligonucleotide, DNA, RNA,data dependent acquisition, tandemmass spectrometry, LC-MS, ion pairingchromatography, IR RPApplication benefits• High resolution accurate mass mass...
Key words
pgd, pgdpad, padptd, ptdpcd, pcdoligonucleotides, oligonucleotidesptdpcd, ptdpcdoligonucleotide, oligonucleotidestepped, steppedfinder, finderpgr, pgrbiopharma, biopharmapur, purnce, nceintensity, intensitylens
An Automated Compliance-Ready LC-MS Workflow for Intact MassConfirmation and Purity Analysis of OligonucleotidesCatalin Doneanu, 1 Jonathan Fox, 2 Emma Harry, 2 Chris Knowles, 3 Ying Qing Yu,1 Joseph Fredette, 1 and Weibin Chen11Waters Corporation, Milford, MA2Waters Corporation, Wilmslow, UK3Waters Corporation,...
Key words
oligonucleotides, oligonucleotidespurity, puritycompliance, complianceintact, intactready, readyoligonucleotide, oligonucleotideconfirmation, confirmationworkflow, workflowoligo, oligoautomated, automatedmass, massnote, noteapplication, applicationacquity, acquitybioaccord
SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES VIA AUTOMATED TOP-DOWN SPECTRAL ANNOTATIONMaria Basanta-Sanchez, Catalin Doneanu, Joe Fredette, Barbara Sullivan, Weibin Chen and Iggy KassWaters Corporation, Milford, MAOVERVIEWRESULTSMETHODSSequence analysis / confirmation of full length modified and non-Materialsmodified oligonucleotides using Spectrum tools.Top-down MS/MSOligonucleotides were purchased...
Key words
rna, rnadna, dnasequence, sequenceannotation, annotationoligonucleotide, oligonucleotidedown, downtop, topmodified, modifiedcharge, chargeenergy, energycoverage, coverageoligo, oligodata, dataspectrum, spectrumspectra
[ APPLICATION NOTEBOOK ]APPLICATION SOLUTIONS FOROLIGONUCLEOTIDES Table of ContentsIntroduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4[ HPLC & UPLC Separations ]Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11Oligonucleotide Separation Technology: Synthesis Challenges and HPLC Isolation Options...
Key words
oligonucleotides, oligonucleotidesoligonucleotide, oligonucleotideuplc, uplcacquity, acquityrnai, rnaiost, ostduplex, duplexpromass, promassduplexes, duplexessirna, sirnawaters, watersqda, qdarna, rnaanalysis, analysispairing
 

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