<p><strong>In the week of February 16, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Agilent Technologies: From Complex to Simplicity – Get More Peace of Mind on Your HPLC Workflows with InfinityLab Assist</strong></h5><ul><li>Mo, 16.2.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5908">Registration</a></li></ul><p>Discover how Agilent InfinityLab Assist simplifies LC system control with intuitive multitouch operation, guided troubleshooting, and smart monitoring to boost efficiency and reduce downtime.</p><h5><strong>2. Thermo Fisher Scientific: Driving the Process Development of Recombinant Therapeutic Products with Automated MS-Based Target Peptide Mapping</strong></h5><ul><li>Tu, 17.2.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5931">Registration</a></li></ul><p>Explore automated MS-based MAM workflows for peptide mapping, enabling faster CMC decisions and scalable analytics from development to QC readiness.</p><h5><strong>3. Thermo Fisher Scientific: PFAS Analysis Solutions – Innovations for Today’s Labs</strong></h5><ul><li>Tu, 17.2.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5818">Registration</a></li></ul><p>Explore the latest challenges and solutions in PFAS analysis for environmental and food testing, including advanced workflows that improve sensitivity, accuracy, and lab efficiency.</p><h5><strong>4. Phenomenex: Understanding and Applying USP Chapter 621 for Generic Pharmaceutical Applications</strong></h5><ul><li>We, 18.2.2026 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5794">Registration</a></li></ul><p>Learn the key guidelines defined in USP &lt;621&gt; and practical examples of how to apply them in generic pharmaceutical method development.</p><h5><strong>5. SCIEX: Genome Integrity Analysis of Adeno-Associated Viruses (AAV) by Genome Sizing Using a SCIEX Capillary Electrophoresis System</strong></h5><ul><li>We, 18.2.2026 11:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5935">Registration</a></li></ul><p>Join this webinar to learn how capillary electrophoresis enables reliable genome integrity analysis of AAV for gene therapy applications.</p><h5><strong>6. Waters Corporation: The Gold Standard – Achieving Optimal Peptide Purification with Reversed-Phase Chromatography</strong></h5><ul><li>We, 18.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5917">Registration</a></li></ul><p>Discover why reversed-phase chromatography remains the gold standard for peptide purification and analytical performance.</p><h5><strong>7. Axcend: Understanding Capillary LC – Part 5: Detectors, Sensitivity, and MS/UV</strong></h5><ul><li>We, 18.2.2026 20:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5829">Registration</a></li></ul><p>Join experts to explore MS, UV, and electrochemical detectors at the capillary scale and learn how to achieve reliable sensitivity in capillary LC workflows.</p><h5><strong>8. Thermo Fisher Scientific: Single Cell and Immunopeptidomics Explorations on Orbitrap Astral MS</strong></h5><ul><li>Th, 19.2.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5932">Registration</a></li></ul><p>Discover how Orbitrap Astral MS and Vanquish Neo HPLC enable deep single-cell proteomics and immunopeptidomics from ultra-low-input clinical samples.</p><h5><strong>9. Evosep Biosystems: Experimental Design Considerations for Scalable Proteomics</strong></h5><ul><li>Th, 19.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5836">Registration</a></li></ul><p>Explore best practices for experimental design in LC-MS–based proteomics to build robust, reproducible, and scalable analytical workflows.</p><h5><strong>10. Waters Corporation: Ask Me Anything About Managing Computerized System Risks to Data Integrity</strong></h5><ul><li>Th, 19.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5809">Registration</a></li></ul><p>Learn practical strategies to manage computerized system risks in regulated laboratories and protect data integrity while ensuring compliance.</p><h5><strong>11. Shimadzu Corporation: Automating a Comprehensive Amino Acid Panel for Inborn Errors of Metabolism</strong></h5><ul><li>Th, 19.2.2026 20:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5936">Registration</a></li></ul><p>Discover how Shimadzu’s CLAM-2040 automates LC-MS/MS sample preparation to standardize workflows, reduce manual handling, and improve consistency in clinical labs.</p>

Webinars LabRulezLCMS Week 08/2026

Imaging of Protein Assemblies up to 231 kDa in Tissues with Nano-DESI Mass Spectrometry

<p><strong>Metalloproteins play essential roles in marine phytoplankton, yet their metalloproteomes remain poorly characterized. This study combines protein modeling, quantitative proteomics, and ICP-MS measurements to assess metal requirements across several phytoplankton species, including chlorophytes, a haptophyte, and a cyanobacterium.</strong></p><p>Results show strong agreement between proteome-inferred metal demands and measured cellular metal quotas, while providing deeper insight into biological functions. Mg-containing proteins were most abundant overall, with Zn, Fe, and Mn as dominant trace cofactors. Distinct differences between prokaryotic and eukaryotic phytoplankton were observed, and strain-level analysis demonstrated how metalloproteomes reflect environmental adaptation and metal limitation strategies.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233"><strong>Unlocking Phytoplankton Metallomes with Comparative Analysis of Metal Quotas, Quantitative Proteomics, and Inferred Metalloproteomes</strong></a></h4><p>Qiong Zhang*, Jiayou Ge, Fengjie Liu, Shabaz Mohammed, Kedong Yin, and Rosalind E. M. Rickaby</p><p>Environ. Sci. Technol. 2025, 59, 50, 27367–27377</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.est.5c11233">https://doi.org/10.1021/acs.est.5c11233</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><p>Many important biological processes of phytoplankton, including photosynthesis, carbon fixation, and nitrogen reduction, rely on enzymes that have metals as cofactors. <a href="javascript:void(0);">(1)</a> It has been estimated that half of all enzymes must be associated with a particular metal to function. <a href="javascript:void(0);">(2)</a> The availability of metals in the environment has changed over geological time and, given imperfections in the selectivity of metal transport systems, proteins have evolved to make the best use of metals that are more available. <a href="javascript:void(0);">(3−5)</a> Depending on their evolutionary histories, different groups of marine phytoplankton may have differences in their metalloprotein compositions and metal transport strategies. The evolving trace metal availability in the environment, thus, may provide a selective pressure to promote the proliferation of different phytoplankton groups in the oceanic environment, affecting the phytoplankton community structure with knock-on effects on the marine food web and carbon sequestration. <a href="javascript:void(0);">(5)</a> It is crucial to understand the utilization of trace metals by different groups of marine phytoplankton that inhabit contrasting niches in the modern ocean, not only by assessing the accumulation of trace metals in cells but also examining the functions of trace metals in different biological pathways.</p><p>In previous studies, the utilization or requirements of trace metals by marine phytoplankton were mostly determined by measuring the elemental stoichiometry in cells (metallome or quota of trace metals). <a href="javascript:void(0);">(6−8)</a> In the field, attempts have also been made to investigate the elements in phytoplankton <a href="javascript:void(0);">(9,10)</a> which have then been compared with profiles in the abiotic environment to understand their relationships. <a href="javascript:void(0);">(11)</a> The discovery of various metal storage proteins and the plasticity in elemental quotas under different environmental conditions raise the question of whether intracellular trace metal quotas reflect true differences in trace metal usage by phytoplankton. <a href="javascript:void(0);">(12,13)</a> In the past few decades, more and more studies have focused on metal–protein partnerships, using approaches such as genome-wide analysis to identify homologues of known metalloproteins and other deduced metal-binding motifs encoded within sequenced genomes. <a href="javascript:void(0);">(5,14)</a> However, this approach has limitations in estimating metal abundance in cells because not all genes predicted in the genome would be translated and expressed as proteins under all environments, and a single gene for a metalloprotein could be highly expressed, such that a translation from genetic presence to a required concentration is not linear and could be environment-dependent. To obtain <i>in situ</i> metal abundance in metalloproteins in cells, native separation of proteins by HPLC or PAGE followed by the detection of metals using ICP-MS <a href="javascript:void(0);">(15,16)</a> has been used. This approach also has limitations in that, without bioinformatics, it cannot identify the function of proteins within which the metals are found, and it may also depend on the composition of the media to which the organism has been exposed and in which it has been growing. An ideal way to solve the problem would be to separate and purify each of the proteins and then identify both the associated metal (<i>e.g.,</i> by ICP-MS) and the protein sequence (<i>e.g.,</i> by mass spectrometry). However, this approach is constrained by the resolution of chromatographic or electrophoretic techniques, making it challenging to establish the metal–protein associations unambiguously; many proteins often co-occur in metal-containing fractions. Additionally, this method requires huge volumes of biomass and is both time-consuming and complex, complicating the reconstruction of the expressed metalloproteome in cells. The techniques and challenges for metalloproteomics have been discussed in detail in previously published review articles (and the references therein). <a href="javascript:void(0);">(17)</a></p><p>In this study, we determined the trace metal utilization (the metallome) of different phytoplankton from their expressed proteome via a protein modeling and homologue identification approach, and then compared the resulting metallome with the metal quota data measured by the traditional inductively coupled plasma mass spectrometry (ICP-MS). This approach allows the building of a link between the truly used trace elements and their biological functions in phytoplankton. We aim to fill the gap between an estimation of metals encoded in the genome and metal analysis by ICP-MS in phytoplankton, which may be more broadly applicable to infer cellular metallomes.</p><h3><strong>Materials and Methods</strong></h3><h4><strong>ICP-MS Analysis</strong></h4><p>All preparation of samples for ICP-MS measurement was undertaken using trace metal clean methods. All plasticware used in this study, including culture flasks, pipette tips, and centrifuge tubes, was precleaned in 10% quartz-distilled HCl and thoroughly rinsed with 18 MΩ cm water in a clean laboratory. Trace elements in the filtered lysates of <i>G. huxleyi</i> (OA1, OA4, OA8, OA15, OA16, OA23, and RCC 1242) and <i>Synechocystis</i> (FACHB898) strains were measured using an ICP-MS. The detailed ICP-MS method and instrumental settings are described in Zhang et al. (2018). <a href="javascript:void(0);">(31)</a></p><h4><strong>Protein Mass Spectrometry</strong></h4><p>The peptides were resuspended in 5% formic acid and 5% DMSO prior to mass spectrometry. They were separated on an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=Ultimate+3000+UHPLC"><strong>Ultimate 3000 UHPLC </strong></a>system (Thermo Fisher Scientific) and electrosprayed directly into a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/559"><strong>Q-Exactive Mass Spectrometer</strong></a> (Thermo Fisher Scientific) through an EASY-Spray nanoelectrospray ion source (Thermo Fisher Scientific). The peptides were trapped on a C18 PepMap100 precolumn (300 μm i.d. × 5 mm, 100 Å, Thermo Fisher Scientific) using solvent A (0.1% formic acid in water) at a pressure of 500 bar. The peptides were separated on an in-house packed analytical column (75 μm i.d. × 50 cm packed with ReproSil-Pur 120 C18-AQ, 1.9 μm, 120 Å, Dr. Maisch GmbH) using a linear gradient (length: 65 min, 15% to 35% solvent B [0.1% formic acid in acetonitrile], flow rate: 200 nL/min). The raw data were acquired on the mass spectrometer in a data-dependent mode (DDA). Full scan MS spectra were acquired in the Orbitrap (scan range 350–1500 <i>m</i>/<i>z</i>, resolution 70000, AGC target 3e6, maximum injection time 50 ms). After the MS scans, the 10 most intense peaks were selected for HCD fragmentation at 30% of normalized collision energy. HCD spectra were also acquired in the Orbitrap (resolution 17500, AGC target 5e4, maximum injection time 120 ms, isolation window 1.5 <i>m</i>/<i>z</i>) with the first fixed mass at 180 <i>m</i>/<i>z</i>. Charge exclusion was selected for unassigned and 1+ ions. The dynamic exclusion was set to 20 s.</p><h3><strong>Results and Discussion</strong></h3><h4><strong>Trace Elements Determined from the Expressed Proteomes of Different Phytoplankton</strong></h4><p>Based on the expressed proteome sequences, we predicted metal-binding proteins and compared their distribution among various phytoplankton species (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233#fig2">Figure 2</a>). The inference revealed 28 different metals in <i>G. huxleyi</i>, 31 different metals in <i>C. reinhardtii</i>, and 30 different metals in <i>Synechocystis</i>. Although only 6 different metals were identified in <i>O. tauri</i> proteins, it has to be noted that the analysis for <i>O. tauri</i> was only based on the 40 most abundant proteins reported in this organism <a href="javascript:void(0);">(21)</a> and, hence, the listed elements, including Mg, Fe, Mn, Ca, Zn, and Cu, may represent the most essential metals for the species.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Environ_Sci_Technol_2025_59_50_27367_27377_Figure_2_The_number_of_metal_binding_proteins_identified_in_the_expressed_proteome_of_the_haptophyte_G_9b8ac0f004.jpeg" alt="Environ. Sci. Technol. 2025, 59, 50, 27367–27377: Figure 2. The number of metal-binding proteins identified in the expressed proteome of the haptophyte G. huxleyi (a), the chlorophyte C. reinhardtii (b) and O. tauri(c), and the cyanobacteria Synechocystis (d). Pie charts show the percentages of metalloproteins containing specific metals. Original proteome data for G. huxleyi are from Mckew et al. (2013) (24) for C. reinhardtii are from Hsieh et al. (2013) (77) for O.tauriare from Martin et al. (2012) (21) for Synechocystisare from Chen et al. (2018). (22) *Noted that for O. tauri, only the 40 most abundant proteins were included in this analysis. ND: no metal binding was found in the proteins." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Environ_Sci_Technol_2025_59_50_27367_27377_Figure_2_The_number_of_metal_binding_proteins_identified_in_the_expressed_proteome_of_the_haptophyte_G_9b8ac0f004.jpeg 123w," sizes="100vw" width="934" height="1181"></p><p>The number of proteins that bind with different metals varies dramatically in phytoplankton. For metalloproteins, there are variations in the binding affinities of different metals to organic molecules. For example, the affinities of divalent metals to proteins have a tendency to follow a universal order of preference, namely the Irving-Williams series (Mg<sup>2+</sup> and Ca<sup>2+</sup> [weakest binding] &lt; Mn<sup>2+</sup> &lt; Fe<sup>2+</sup> &lt; Co<sup>2+</sup> &lt; Ni<sup>2+</sup> &lt; Cu<sup>2+</sup> &gt; Zn<sup>2+</sup>). <a href="javascript:void(0);">(43)</a> Cells can simultaneously contain proteins having high-affinity-binding metals, such as Cu and Zn, and others that require uncompetitive metals, such as Mg and Ca. One of the least competitive metals for binding with biological chelators, Mg, is even found to be the most widely distributed metal in the metalloproteomes of various phytoplankton species in this study, supporting the observations of high concentrations in the protein fraction of cells (at millimolar concentrations <a href="javascript:void(0);">(31)</a>).</p><p>In all phytoplankton species in our analysis, the Mg-containing proteins are found to have the highest proportion in all metalloproteins identified. About 30% of the metalloproteins in different strains of phytoplankton are found to contain Mg or depend on it for function (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233#fig2">Figure 2</a>), suggesting the important role of Mg in phytoplankton cells. It is generally coordinated in protein complexes by ATP or ADP and has also been found to be largely distributed in the chloroplasts or thylakoids in <i>G. huxleyi</i> and <i>Synechocystis</i>. <a href="javascript:void(0);">(22,24)</a> The essential roles of Mg in plants have been reported in various studies. Mg<sup>2+</sup> is known to be the central atom of the chlorophyll molecule, and its levels in the chloroplast regulate the activity of key photosynthetic enzymes. <a href="javascript:void(0);">(44)</a> It was reported that approximately 15–35% of total Mg is in the chloroplasts of a plant, <a href="javascript:void(0);">(45)</a> and it also serves as an osmotically active ion in the regulation of cells <a href="javascript:void(0);">(46)</a></p><h4><strong>Comparison Between Metallome Measured Directly and Reconstructed from Proteins</strong></h4><p>A large proportion of metals, such as Fe, Mn, and Cu, are found in membrane proteins,and may contribute significantly to total cellular quotas. <a href="javascript:void(0);">(54,55)</a> However, for method development purpose, we endeavored to remove the cell membranes from our samples to focus mostly on the analysis of intracellular metal quotas and metalloproteins in the cytosol fraction in this study. We note that our analysis includes some membrane-bound proteins likely derived from organelles or surface membranes disrupted during sonication.</p><p>The derivation of cellular metal composition, as determined by two different methods, is compared in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233#fig3">Figure 3</a>. The abundance of metal in the proteins is determined as the relative abundance of the protein multiplied by the number of metal ions needed for the specific protein. The abundance of the proteins was normalized to ensure that the total intensities from each replicate measurement for the same species were similar. Since the proteomic data used here were generated from different studies using different instruments, we cannot quantify or compare the absolute biomass of proteins used for each species. Therefore, we cannot compare the absolute trace metal abundance between species solely from metal inferences of expressed proteomes. Nevertheless, we can estimate the relative abundance of different metals in the same species. For the elements that are both measured by the ICP-MS and identified in the proteome, there are generally good correlations (<i>r</i><sup>2</sup> = 0.81 in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233#fig3">Figure 3</a>a and <i>r</i><sup>2</sup> = 0.74 in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233#fig3">Figure 3</a>b) between the two approaches. This indicates that the metal compositions determined from the protein modeling may be reliable and, therefore, can reflect the metal usage in different phytoplankton. This would provide a level of assurance to further investigate the metal binding associated with various proteins, thereby deepening our understanding of the roles that different metals play in phytoplankton.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Environ_Sci_Technol_2025_59_50_27367_27377_Figure_3_Relationship_between_the_abundance_of_metals_determined_by_ICP_MS_analysis_e7b259e376.jpeg" alt="Environ. Sci. Technol. 2025, 59, 50, 27367–27377: Figure 3. Relationship between the abundance of metals determined by ICP-MS analysis (normalized to C, mmol/mol C) and metal abundance determined from the metalloproteome analysis (the unit is arbitrary). To account for strain variations, the ICP-MS data for the cellular metal content of G. huxleyi are average values from 7 G. huxleyi strains isolated from different areas of the ocean, and the proteome-derived metal composition data are average values calculated from 2 of those G. huxleyi strains (OA1 and OA16) isolated previously, and data from Mckew et al., 2013. (24) The ICP-MS data for Synechocystis are from Synechocystis sp. FACHB898 measured in this study, and the proteome data are calculated from Chen et al., 2018. (22) Noted that the abundance of metals from each proteome was calculated by using the metal stoichiometry multiplied by the relative abundance of proteins, which provides only a relative relationship of different trace metals, not absolute abundance. The symbols represent the mean values, and the error bars indicate standard deviations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Environ_Sci_Technol_2025_59_50_27367_27377_Figure_3_Relationship_between_the_abundance_of_metals_determined_by_ICP_MS_analysis_e7b259e376.jpeg 245w," sizes="100vw" width="1384" height="641"></p><p>Compared to the other metals investigated in this study, Ca and Mg appear to have a much higher relative abundance in the ICP-MS analysis than in the proteomic analysis of <i>G. huxleyi</i> and <i>Synechocystis</i> (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233#fig3">Figure 3</a>). These two elements are essential macronutrients for phytoplankton and plants. Ca is the most prominent secondary messenger that plays a crucial role in response to extracellular stimuli in all eukaryotes. Ca<sup>2+</sup> fluxes are transported via Ca channels and transporters, such as Ca-ATPase, regulating a series of important biological functions, including mineral uptake and utilization, K<sup>+</sup> homeostasis adjustment, and regulatory network activity in response to P or N deficiency. <a href="javascript:void(0);">(56)</a> Ca is not always incorporated into protein structures. The Ca abundance determined from the proteins in this study, therefore, is much lower than the actual Ca needed intracellularly. Similarly, the intracellular Mg<sup>2+</sup> and K<sup>+</sup> abundances should also be higher than those determined from the protein structures. Free Mg<sup>2+</sup> and K<sup>+</sup> are known to regulate cation–anion balance and serve as osmotically active ions in the regulation of cells <a href="javascript:void(0);">(46)</a> but free metal ion concentrations cannot be determined through the approach used in this study. Thus, it is not surprising to see much higher relative abundances of Ca and Mg in ICP-MS analysis than in proteomic analysis (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.5c11233#fig3">Figure 3</a>).</p>

Unlocking Phytoplankton Metallomes with Comparative Analysis of Metal Quotas, Quantitative Proteomics, and Inferred Metalloproteomes

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By mitigating non-specific binding, the ACQUITY Premier Solution provides:</p><ul data-spread="false"><li>Dramatic improvements in RP and HILIC applications for organic acids, organophosphates, oligonucleotides, peptides, glycans, and phospholipids</li><li>Increased sensitivity reducing risk of undetected analytes</li><li>Increased efficiency by eliminating time-consuming system and column passivation</li><li>Greater reproducibility and increased confidence in results</li></ul><figure class="image"><img style="aspect-ratio:1183/1177;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_3_ca85533e85.jpg" alt="Waters ACQUITY PREMIER Solution: ACQUITY Premier Solution performance without time-consuming passivation – analysis of insulin receptor – doubly phosphorylated peptide (TRDIpYETDpYYRK)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_3_ca85533e85.jpg 157w," sizes="100vw" width="1183" height="1177"></figure><h3><strong>Holistic solutions for optimal performance</strong></h3><p>A true measure of excellence for Waters is in orchestrating consistent instrument and chemistry optimization, enabling you to fine-tune your system to your specific analytical need, rapidly change between applications, and consistently maintain a high level of confidence in every result.</p><p>The outcome is better quality data faster and improved system-to-system and column-to-column reproducibility, allowing methods to be transferred between analysts, instruments, and laboratories.</p><figure class="image"><img style="aspect-ratio:1534/1271;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4e1b9e6b60.jpg" alt="Waters ACQUITY PREMIER Solution: The ACQUITY Premier Solution significantly reduces analyte/surface interaction of sensitive compounds for improved chromatographic performance in RPLC/MS-based separations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4e1b9e6b60.jpg 188w," sizes="100vw" width="1534" height="1271"></figure><h3><span><strong>Improve spectral quality and analyte identification</strong></span></h3><p><span>Obtaining high-quality mass spectrometry spectra is central to structural elucidation and analyte identification. The process of obtaining these spectra is often confounded by spectral overlap from closely eluting analytes or poor-quality MS signal due to low peak concentration. MaxPeak HPS Technology eliminates secondary interactions from metals, reducing chromatographic peak tailing. The result is more gaussian peaks, reduced chromatographic coelution, and superior spectral quality.</span></p><figure class="image"><img style="aspect-ratio:1291/1172;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg" alt="Waters ACQUITY PREMIER Solution: Improve spectral quality and analyte identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg 171w," sizes="100vw" width="1291" height="1172"></figure><h3><span><strong>Global Services: Committed to your success</strong></span></h3><p data-pm-slice="1 1 []"><span>As part of the ACQUITY Premier experience, one of our applications specialists will work with you to ensure you are getting everything you need from your system. We have a flexible range of support plans to ensure you get the most out of your system:</span></p><h4><span><strong>FlexChoice™ MySystem Coverage&nbsp;</strong></span></h4><p><span>Choose the support you need – no more, no less. The Waters service team offers personalized and flexible support, maintenance, and service options to meet your unique lab requirements.</span></p><h4><span><strong>Compliance Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Simplify your process of validating, qualifying, and record-keeping with consulting services to help meet your regulatory guidelines.</span></p><h4><span><strong>Professional Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Waters comprehensive suite of consultative services, software applications, and analytical business tools guide you on your path to increased efficiencies and lower costs.</span></p><h4><span><strong>FlexUp™ Technology Renewal Program</strong></span></h4><p data-pm-slice="1 1 []"><span>Benefit from ongoing seamless upgrades to our latest LC and mass spec instrumentation and software and eliminate the issues associated with older instrumentation.</span></p><p><span>*Coming soon to all regions.</span></p><h3><span><strong>Informatics: Get more from your data for more trusted decisions</strong></span></h3><p><span>Capture, manage, integrate, and analyze your LC and MS data with our informatics platforms, improving discovery and manufacturing, quality and integrity, and reducing time to market. Easily and seamlessly conduct scientific searches, integrate networks, manage compliance, and streamline operations.</span></p><h4><span><strong>Empower™ Chromatography Data System</strong></span></h4><p data-pm-slice="1 1 []"><span>Your entire laboratory operates better with Empower Software, which makes it easier than ever to run samples and produce meaningful results, all while ensuring adherence to strict compliance requirements.</span></p><h4><span><strong>MassLynx™ Software</strong></span></h4><p data-pm-slice="1 1 []"><span>Increase laboratory productivity with Waters MassLynx™ Software, which simplifies interaction with and improves your MS system with an intuitive interface, intelligent instrument control, and software features built around the focus of your analysis - the sample.</span></p><h4><span><strong>Unifi™</strong></span></h4><p data-pm-slice="1 1 []"><span>Merges LC and high-performance MS data into a single solution, providing organizations with the flexibility to deploy UNIFI-based systems within regulated and non-regulated laboratory environments.</span><br><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg" alt="Waters ACQUITY PREMIER Solution " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Waters ACQUITY UPLC H-Class PLUS System

Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution.

<div><div><h4><strong>Performance that advances your lab</strong></h4></div></div><div><div><p><strong>Whether your goal is to rapidly develop new methods or to routinely analyze large numbers of incoming samples, the ACQUITY UPLC H-Class PLUS System can help you decrease the time to result, while increasing the depth and quality of information received from your sample analysis.</strong></p><p>With the ACQUITY UPLC H-Class PLUS System, you can improve laboratory productivity by transitioning methods to UPLC/UHPLC technology, improve the characterization of your most complex samples through enhanced resolution and leverage advanced tools to simplify and streamline your method development workflow.</p><div><div><div><div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution. The system provides on-demand solvent blending and support for any analytical LC column, making it an ideal choice for modernizing existing or developing new methods." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div><ul><li><strong>Get the flexibility of multi-solvent blending</strong> - Blend up to nine solvents with integrated solvent-select valve with the Quaternary Solvent Manager&nbsp;</li><li><strong>Deliver precise and accurate binary solvent blending</strong> - Blend up to four solvents with integrated solvent-select valve with the Binary Solvent Manager</li><li><strong>Get high-precision injections with direct inject sampling&nbsp;</strong>- The needle-in-flow path design ensures an accurate needle seal at high pressure</li><li><strong>Get accurate temperature control across the entire column</strong> - Configurable for 1 to 6 columns with active preheating</li><li><strong>Automate the formulation of mobile phases</strong> - Significantly reduce the time you spend in the prep lab with&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"> Auto•Blend Plus </a>Technology</li><li><strong>Transfer methods more easily</strong> - Easily adjust for system volume differences when transferring methods from an alternative LC system without alteration to the method table using Gradient SmartStart </li><li><strong>Wide software support</strong> – ACQUITY UPLC H-Class PLUS System is supported by  <strong>Empower, MassLynx, UNIFI</strong>, and several 3rd party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Improving laboratory productivity by transitioning methods to UPLC technology.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: A highly reliable and robust LC-MS system without any compromise in speed, resolution, or sensitivity, especially in everyday settings. The ACQUITY H-Class PLUS Binary System combines an optimized flow path resistant to clogging, stable high-pressure gradient formation, and support for sub-2-µm to 5-µm particle columns to deliver the ideal choice for reproducible everyday LC-MS analyses with any tandem quad or Q-ToF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div><div><div><h3><strong>Discover the UPLC difference</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS System</strong> is the next evolution of ultra-performance instrumentation, providing the <strong>high resolution</strong> of a <strong>quaternary or binary liquid chromatography (LC) system</strong>.</p><p>Achieving <strong>true UPLC performance</strong> requires that system dispersion (or extra-column band spread) be matched to the peak widths associated with narrow bore columns packed with <strong>sub-2-μm particles</strong>. While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the <strong>sharp peaks of UPLC performance</strong> and the <strong>ACQUITY UPLC H-Class PLUS System</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Comparison of the same method with the same column on a low-dispersion ACQUITY UPLC H-Class PLUS System versus a higher-dispersion UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg 245w," sizes="100vw" width="1024" height="555"></p></div></div><div><div><h3><strong>Take your methods to the next level</strong></h3><p>Leverage the benefits of <strong>UPLC technology</strong> to improve your existing <strong>HPLC methods</strong>. By scaling your methods to UPLC, your laboratory will benefit from the combination of <strong>increased resolution, sensitivity, and speed</strong> that comes with modern small particle chemistries.</p><p>Designed to accommodate all of your LC method needs, the <strong>ACQUITY UPLC H-Class PLUS System</strong> is ideally suited to <strong>future-proof your laboratory</strong>, enabling the support of existing HPLC methods now, and provide <strong>significant productivity and cost benefit</strong> when utilized for UPLC methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: The USP analysis of diclazuril and organic impurities was scaled from HPLC to UHPLC to UPLC. The UPLC method resulted in a 4x reduction in run time and a 10x reduction in solvent consumption resulting in improved sample throughput and reduced cost per analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg 245w," sizes="100vw" width="1024" height="613"></p></div></div><div><div><h3><strong>Discover the best method for the best results</strong></h3><p>Get the <strong>versatility</strong> to discover the best set of chromatographic conditions for your sample, providing a <strong>more robust method</strong>. The flexibility of the <strong>ACQUITY UPLC H-Class PLUS Quaternary System</strong> allows you to <strong>automatically screen important method parameters</strong>, including:</p><ul><li>Up to <strong>six columns</strong> in independently temperature-controlled compartments</li><li>pH and ionic strength with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"><strong>Auto•Blend Plus</strong></a><strong> Technology</strong></li><li><strong>Optional and integrated solvent selection valve</strong> expands access to six additional mobile phase lines&nbsp;</li><li><strong>11 unique gradient profiles</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: (A) Auto·Blend Plus method gradient table for trastuzumab pH optimization. (B) pH optimization on trastuzumab charge variants separation. Gradient: 20 mM MES buffer, 50–155 mM NaCl in 15 min." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg 245w," sizes="100vw" width="1024" height="622"></p></div></div><div><div><h3><strong>Deliver greater speed and precision for routine analyses</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> combines the <strong>proven reliability and performance</strong> of the H-Class PLUS System with the <strong>precision and lowest system volume</strong> offered by our <strong>high-pressure mixing binary solvent manager</strong>, allowing you to:</p><ul><li>Accommodate the <strong>most challenging sample matrices</strong></li><li>Tackle applications with <strong>long shallow gradients</strong></li><li><strong>Improve the throughput</strong> of your methods</li></ul><p><strong>Combine </strong>the capabilities of the <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> with <strong>Waters </strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Tandem-Quadrupole-%28-Triple-Quadrupole-%29-Mass-Spectrometry/nav.htm?cid=134656172"><strong>Tandem quadruple technology</strong></a><strong> </strong>for routine quantitative UPLC-MS/MS applications, so you can confidently quantify and trace components in the most complex of samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Direct transfer without a gradient delay offers the opportunity for method improvement with the analysis time going from 5 minutes to 3 minutes representing a 40% reduction in runtime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg 245w," sizes="100vw" width="1024" height="600"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 15,000 psi</li><li><strong>pH range</strong>: 1–12.5 (<i><span>For specific test conditions, contact your Waters sales representative)</span></i></li><li><strong>Operating flow rate range</strong>: Up to 2.2 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: ≤0.002% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary, Quaternary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 6 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications</strong> <strong>(QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div></div></div></div></div>

Waters ACQUITY UPLC I-Class PLUS System

With the ACQUITY UPLC I-Class PLUS System, your lab can achieve highly efficient, rapid separations from ultra-low dispersion and delay volume.

<div><div><h4><strong>Complex chromatography challenges, solved</strong></h4></div></div><div><div><p><strong>Looking for answers to the most complex scientific challenges is what you do, and the scientific tools you deploy and the information they provide can make all the difference. With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS System provides new possibilities for maximizing the resolution and sensitivity of your methods, enhancing the characterization of your samples, and improving productivity to advance the science of your laboratory.</strong></p><div><div><div><div><p>With the <strong>ACQUITY UPLC I-Class PLUS System</strong>, your lab can achieve <strong>highly efficient, rapid separations</strong> from <strong>ultra-low dispersion and delay volume</strong>. The system enables your lab to get <strong>narrow, ultra-efficient peaks</strong>, enhancing the <strong>sensitivity of any mass spectrometer</strong> and simplifying the characterization of the most complex sample.</p><ul><li><strong>Achieve precise and accurate binary solvent blending</strong> with the Binary Solvent Manager, ideal for up to four solvents with integrated solvent-select valve</li><li><strong>Get sample injection versatility</strong>, depending upon your application with the flow-through needle and fixed loop injector options</li><li><strong>Manage ultra-low carryover</strong> through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers</li><li><strong>Get accurate temperature control</strong> across the entire column, configurable for 1 to 2 columns with active preheating</li><li><strong>Improve the performance of any mass spectrometer</strong> with the highest chromatographic resolution which minimizes interference from co-elutions</li><li><strong>Minimize the time and cost</strong> associated with annual qualification with the Waters Empower-based automated system qualification tool (SQT)</li><li><strong>Supported by Empower, Masslynx, UNIFI</strong>, and several third-party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p><strong>Enhance the characterization of your samples</strong>, while <strong>improving productivity</strong> to advance the science of your laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: ACQUITY UPLC I-Class PLUS System FTN-H PDA angled." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg 245w," sizes="100vw" width="1024" height="637"></p><div><div><div><div><h3><strong>Get a clearer picture of your sample</strong></h3><p>Get improved resolution through <strong>reduced system dispersion</strong> with the <strong>ACQUITY UPLC I-Class PLUS System</strong>, providing separations that can amplify your research.</p><p><strong>Shorten analysis times</strong>, <strong>reduce solvent usage</strong>, and <strong>speed access to the data</strong> you need for critical decisions. Designed to fit into your existing LC workflow, the ACQUITY UPLC I-Class PLUS System provides a <strong>clear view into what lies within the sample</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg 245w," sizes="100vw" width="1024" height="595"></p></div></div></div></div></div></div></div></div><div><div><h3><strong>An inlet that improves the performance of any MS</strong></h3><p>The ACQUITY UPLC I-Class PLUS System is designed specifically for the <strong>rapid pace of laboratories</strong> on the <strong>cutting edge of research</strong> where <strong>LC-MS plays a critical role</strong>.</p><p><strong>With the ACQUITY UPLC I-Class PLUS System, your lab will:</strong></p><ul><li><strong>Improve resolution and ionization efficiency</strong> with narrow peak widths, enhancing <strong>mass spectrometry sensitivity</strong></li><li><strong>Enhance sensitivity</strong> through <strong>industry-leading carryover performance</strong></li><li><strong>Improve sample characterization</strong> through <strong>selective isolation</strong> with multidimensional UPLC configurations</li><li><strong>Achieve exceptionally fast analysis times</strong> with <strong>ultra-low delay volume</strong></li><li><strong>Achieve ultimate peak capacity</strong> with <strong>CORTECS Columns</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg 182w," sizes="100vw" width="1024" height="878"></p></div></div><div><div><h3><strong>Achieve ultimate peak capacity with CORTECS Columns</strong></h3><p>When paired with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/columns/cortecs-columns.html"><strong>CORTECS 1.6 µm solid-core columns</strong></a>, the ACQUITY UPLC I-Class PLUS System enables scientists to achieve new levels of resolution, sensitivity, and chromatographic performance. With <strong>CORTECS Columns</strong> and the ACQUITY UPLC I-Class PLUS System, you can increase resolution for even your toughest samples and get the flexibility and power you need to rapidly separate a wide array of compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg 210w," sizes="100vw" width="1024" height="761"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 18,000 psi</li><li><strong>pH Range</strong>*: 1–12.5</li><li><strong>Operating flow rate range</strong>: Up to 2.0 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: &lt;0.001% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 2 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications (QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div>

Waters ACQUITY Arc LC System

The ACQUITY™ Arc™ System is an all-in-one platform for HPLC and UHPLC, designed for robust method development and seamless transfer between modern LC systems, addressing a wide range of analytical challenges.

<p class="cke-user_style-important"><strong>Built upon a foundation of reliability</strong></p><p data-pm-slice="1 1 []"><strong>The method development process is changing. New regulations, software and analytical technologies are rapidly changing how methods are designed, transferred, and monitored over their lifecycle. An all-in-one platform for HPLC and UHPLC separations, the ACQUITY™ Arc™ System is designed to meet the spectrum of challenges you face from robust method development to seamless transfer between any modern LC systems.</strong></p><p data-pm-slice="1 1 []">With the <strong>ACQUITY Arc System</strong>, you can experience true plug-and-play method compatibility for HPLC and UHPLC separations. Significant productivity gains can be realized by deploying a single LC platform that allows for the efficient transfer, adjustment, and improvement of methods from any LC platform without compromise in method integrity.</p><figure class="image"><img style="aspect-ratio:768/886;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_63246061ea.jpg" alt="Waters ACQUITY Arc System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_63246061ea.jpg 136w," sizes="100vw" width="768" height="886"></figure><p data-pm-slice="1 1 []">Laboratory-driven organizations have relied on Waters for over 60 years to deliver reliable, robust, and reproducible solutions to ensure confidence in their analytical results. With over 100,000 LC systems installed, we understand the significant impact the right technology has on your business, and the implications it has on characterizing the quality and safety of your products.</p><p data-pm-slice="1 1 []">Methods with greater agility, robustness, and capacity for change can help you reduce regulatory burden, risk of failure and costs. Visit <a disabled="true">www.methods.waters.com</a> to learn more about how method life cycle management (MLCM) connects your method today to your method tomorrow.</p><h3><strong>Designed for discovery to routine QC applications</strong></h3><p>The <strong>ACQUITY Arc System</strong> is the only available LC system with regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument. With unrivaled column capacity and Arc Multi-flow path™ technology, the<strong> ACQUITY Arc System</strong> allows you to generate new methods and modernize legacy HPLC methods faster than ever before.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Comprehensive detector portfolio</strong></h4><p>High-performance analytical detectors designed to maximize HPLC and UHPLC performance, delivering exceptional sensitivity and linearity for your assays.</p><p>Photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, and mass detection, including the ACQUITY QDa™ Detector.</p><h4><strong>Gradient SmartStart</strong></h4><p>Automatically manage gradient start time and pre-injection steps to maximize sample throughput. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.</p><h4><strong>Quaternary solvent management</strong></h4><p>Precise and accurate blending of up to four solvents with automated solvent compressibility compensation. Increase solvent flexibility with an optional, integrated solvent select valve, providing access to six additional solvents.</p><h4><strong>Negligible carryover</strong></h4><p>Advanced flow-through needle design minimizes carryover by continuously cleansing the needle during run. User-configurable wash settings provide flexibility to address even the most complex sample matrices.</p><h4><strong>Thermal management options</strong></h4><p>Column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm, with a temperature range of 4 °C to 90 °C. Integrated column selection valve options provide unattended, fast column changeover.</p><h4><strong>Auto•Blend™ Plus Technology</strong></h4><p>Program gradients directly in terms of pH and ionic strength to minimize manual mobile phase preparation, reduce potential for human error, and accelerate method robustness testing for chromatographic methods.</p><h4><strong>Arc Multi-flow path technology</strong></h4><p>Delivers plug-and-play method compatibility with HPLC or UHPLC methods with the flip of a switch.</p><p>Easily replicate or improve established methods by simply selecting between Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention.</p><h4><strong>Column Technology</strong></h4><p>Industry-leading selectivity choices to meet the needs of virtually every LC application.</p><h4><strong>Laboratory Informatics</strong></h4><p>Software control within your existing Empower™ or MassLynx™ infrastructure.</p><h3><strong>Replicate your established methods</strong></h3><p data-pm-slice="1 1 []">The <strong>ACQUITY Arc System</strong>, enabled by unique Arc Multi-flow path technology, easily accepts and replicates methods from any HPLC platform, without compromise.&nbsp;</p><p data-pm-slice="1 1 []">Whether you are trying to replicate an out-of-date HPLC method, transfer methods across the organization, or to contract partners, the <strong>ACQUITY Arc System</strong> gives you ultimate flexibility to reproduce, modernize, and transfer existing methods with ease and greater cost efficiency, while preserving the integrity of your methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg" alt="Waters ACQUITY Arc System: Analysis run on a Vendor X LC system and replicated on the ACQUITY Arc System. Conditions: 15 to 35% B in 3 min, 35 to 95% B in 2 min; Mobile phase A: 0.1% HCOOH in H 2 O, mobile phase B: 0.1% HCOOH in ACN; Flow rate = 2.0 mL/min; Column: XSelect™ CSH C 18 , 4.6 x 150 mm, 5 μm; Temp. = 30 °C; UV@ 260 nm; 10.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg 245w," sizes="100vw" width="1099" height="596"></p><p>Upgrade your laboratory with a versatile, modern LC system that delivers HPLC and UHPLC method compatibility at the flip of a switch.</p><h3><strong>Modernize your methods</strong></h3><p>The United States Pharmacopeia (USP) is championing pharmacopeial harmonization and modernization efforts, and international organizations are following suit. As a result, the USP is encouraging the modernization of older compendial methods to ensure they are fit for purpose.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg" alt="Waters ACQUITY Arc System: Quetiapine fumarate system suitability solution analyzed on the ACQUITY Arc System using HPLC, UHPLC, and UPLC™ column/method conditions for the quetiapine impurity method. Peak identification: (1) quetiapine related compound G, (2) quetiapine related compound B, (3) quetiapine desethoxy, and (4) quetiapine." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg 245w," sizes="100vw" width="1092" height="678"></p><p>Revisions to these guidelines give you more flexibility to modify your existing pharmacopeial methods with modern techniques and technologies, and in some cases avoid revalidation. The <strong>ACQUITY Arc System</strong>, featuring the Waters Columns Calculator, allows you to confidently scale your gradient methods from a 3.5 μm to a 2.5 μm particle, decreasing run times, lowering solvent consumption, and increasing sample throughput.</p><h3><span><strong>Save time. Reduce cost.</strong></span></h3><p data-pm-slice="1 1 []">With the right column, the <strong>ACQUITY Arc System</strong> is the ideal solution to accommodate methods from any LC platform.&nbsp;</p><p data-pm-slice="1 1 []">From concept to production, the transition your product takes through the product development cycle often requires rigorous LC assays to properly characterize and assess its readiness to advance to the next stage. These LC assays are often adapted to accommodate the technology available from one stage to the next, in some cases requiring an adjustment from a smaller particle size (sub-2-μm) to a larger particle size (2.5 μm–5 μm).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System enables the support of HPLC and UHPLC methods on a single platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg 173w," sizes="100vw" width="959" height="860"></p><p>The <strong>ACQUITY Arc System</strong> provides the flexibility to maximize productivity through efficient and rapid 2.5 μm–2.7 μm UHPLC separations, or to accommodate larger 3.0 μm–5 μm HPLC particles.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg" alt="Waters ACQUITY Arc System: Save time. Reduce cost." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg 245w," sizes="100vw" width="1683" height="469"></p><h3><span><strong>Mitigate your risk</strong></span></h3><p data-pm-slice="1 1 []">With an expanded range of column manager options enabling up to 15-column switching from 4 °C to 90 °C, the <strong>ACQUITY Arc System</strong> will help you significantly reduce the time spent generating robust methods. Equipped with the plug-and-play ACQUITY QDa Mass Detector, the <strong>ACQUITY Arc System</strong> tracks peaks in your method and reveals hidden coelutions of similar analytes, ensuring you have complete confidence in the reliability and reproducibility of your method now and far into the future.</p><h4><strong>Thermal management options</strong></h4><p data-pm-slice="1 1 []">Active and passive pre-heating options available, with up to 15-column switching from 4 °C to 90 °C. Automated monitoring and tracking of column usage with eCord™ technology available with active pre-heating options.</p><h4><strong>Quaternary solvent management</strong></h4><p data-pm-slice="1 1 []">Accelerate your method development with precise and accurate blending of up to four solvents. Increase solvent flexibility with an optional solvent select valve, providing access to six additional solvents.</p><h4><strong>Auto•Blend Plus Technology</strong></h4><p data-pm-slice="1 1 []">Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</p><h4><strong>Comprehensive detector portfolio</strong></h4><p>Diverse portfolio of detectors for method development, method transfer, and routine use.</p><h4><strong>ACQUITY QDa Detector</strong></h4><p>Mass detection built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no adjustments, it easily integrates with your<strong> ACQUITY Arc System.</strong></p><h5><strong>Support</strong></h5><p data-start="0" data-end="175">Empower eLearning modules to help train your lab on Empower 3 and Method Validation. Applications support that’s customized based on your method development needs.</p><h5><strong>Consumables</strong></h5><p data-start="177" data-end="410" data-is-last-node="">Industry-leading selectivity choices to meet the needs of virtually every LC application. Quality Control (QC) Reference Material benchmarks your <strong>ACQUITY Arc System </strong>and enables perfect resolution. Certified clean vials.</p><h5><strong>Laboratory Informatics</strong></h5><p>Software control within your existing Empower or MassLynx infrastructure. Empower 3 Method Validation Manager allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</p><h3><span><strong>Develop methods that stand the test of time</strong></span></h3><p>Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.</p><p>The <strong>ACQUITY Arc System</strong> is fully compatible with the ACQUITY Arc, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram, leaving nothing to chance.</p><ul><li>Confirm the identity of peaks in a separation without injecting standards.</li><li>Identify new peaks in a separation with molecular weight information.&nbsp;</li><li>Detect unresolved peaks and determine if a peak is homogeneously pure.</li><li>Easily track peaks as method conditions are changed.</li></ul><p data-start="272" data-end="600">Using Empower 3 Software and its Custom Calculations and Custom Reporting functions enables you to quickly and automatically evaluate chromatographic data. Configurable reports allow you to choose optimal conditions based on metrics rather than judgment, ensuring a comprehensive assessment of data and best method conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_7_e7ef959203.jpg" alt="Waters ACQUITY Arc System: Method transfer of USP Assay for Fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. Conditions: Mobile phase: 20:80 acetonitrile/ water; Flow rate = 0.5 mL/min; Column: XSelect HSS T3, 4.6 x 150 mm, 3.5 μm; UV@ 260 nm; 20.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_7_e7ef959203.jpg 224w," sizes="100vw" width="939" height="654"></p><h3><strong>Streamline your workflow</strong></h3><div><div data-message-author-role="assistant" data-message-id="7b732be9-0a45-45fb-b585-70a90c1a74d6" dir="auto" data-message-model-slug="gpt-4o"><div><div><p data-start="602" data-end="827">How would you benefit from increased assay consistency between analysts and from lab to lab? What would you gain by accelerating your robustness testing prior to transferring methods to QA/QC?</p><p data-start="829" data-end="1392" data-is-last-node="">Auto•Blend Plus Technology is a novel software tool that extends traditional quaternary solvent blending to permit gradient programming directly in units of pH and ionic strength, providing the ability to vary composition in even the smallest increments of pH (even those differing by 0.1 pH units or less).&nbsp;</p><p data-start="829" data-end="1392" data-is-last-node="">With Auto•Blend Plus, the cumbersome and error-prone approach of manually preparing several pre-mixed mobile phases can now be eliminated with on-demand mobile phase creation, providing significant time savings and improved productivity to the laboratory.</p></div></div></div></div>

Waters Arc Premier LC System

The Arc Premier System features new, innovative MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interactions, without complicated mobile phases or laborious methods.

<div><div><h4><strong>See clearly and consistently, with confidence.</strong></h4></div></div><div><div><p><strong>Today’s scientists and lab managers need to confidently produce the most accurate, reliable, and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily.&nbsp;</strong></p><p>The <strong>Arc Premier System</strong> features the new, innovative solution of <strong>MaxPeak High Performance Surfaces (HPS) Technology</strong>, which effectively reduces non-specific adsorption due to metal interaction — without complicated mobile phases or laborious methods. The <strong>Arc Premier System</strong> sharpens chromatographic peaks for <strong>metal-sensitive compounds</strong> by eliminating secondary interactions from metals, resulting in:</p><ul><li>Improved compliance from higher quality data</li><li>Faster, more reproducible, and accurate data integration</li><li>Shorter time from sample to result, without conditioning</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_6d7c95a93a.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_6d7c95a93a.jpg 245w," sizes="100vw" width="1024" height="611"></p><p>With the Arc Premier System, we continue to deliver on the product quality you expect, combined with recent innovations in <strong>MaxPeak HPS Technolog</strong>y, to always deliver the<strong> best possible results</strong>.&nbsp;</p><p>Whether you are working to ensure the safety of a new and innovative product, maintain the consistency and supply of a current one, or test your food safety and quality, the Arc Premier System gives you<strong> greater data quality, flexibility, reproducibility, and faster data integration </strong>with right first-time results right out of the box, <strong>without the need for complicated mobile phases and laborious methods to prepare your system.</strong></p><div><div><div><div><div><div><ul><li><strong>MaxPeak HPS Technology</strong>, minimizing risk of metal-analyte interactions</li><li>Pressure envelope extends to <strong>9500 psi </strong>through a flow rate range of <strong>1–5 mL/min</strong>, providing an optimized pairing with column dimension and particle size</li><li><strong>Flexible quaternary and binary pumping options</strong></li><li>High performance analytical optical detectors, include photodiode array (PDA), UV/Vis, and fluorescence (FLR)</li><li>Mass detection options with the <strong>ACQUITY™ QDa™ Mass Detector</strong>,<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1543"> <strong>SQD2 Detector</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/209"><strong>Xevo™ TQ-S micro</strong></a>, and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/212"><strong>Xevo TQ-S cronos</strong></a></li><li>Flexible column manager options available for up to six columns ranging in length from <strong>50 mm to 300 mm</strong>, with a temperature range of <strong>4 °C to 90 °C</strong></li><li><strong>Auto•Blend Plus™ Technology</strong> for mobile phase reproducibility and <strong>Gradient SmartStart</strong> for method transfer</li><li>Wide range of trusted particle technologies in <strong>MaxPeak Premier Columns</strong></li><li>Compliance-ready<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627"><strong>Empower™ Chromatography Data System</strong> </a>(CDS) delivering high quality data integrity</li><li>Automated quantification tools to minimize compliance costs and time</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_2_d1a922ae6d.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_2_d1a922ae6d.jpg 245w," sizes="100vw" width="1024" height="585"></p></div></div><div><div><h3><strong>Flexible and Robust HPLC Designed for Your Development and Routine Testing Needs</strong></h3><ul><li><strong>Low dispersion HPLC: </strong>High performing HPLC with bandspread of &lt;30 μL for high chromatographic resolution.&nbsp;</li><li><p><strong>Versatile column management: </strong>Support for analytical LC column dimensions up to 300* mm with capacity to automatically select between as many as six analytical columns. Equipped with independently controlled temperature zone, active pre-heating, and<strong> eCord™ Intelligent Chip Technology </strong>for Waters columns.</p><p>* MaxPeak Premier Columns are recommended for use with the Arc Premier System and are currently only available in lengths up to 150 mm.</p></li><li><strong>Flow-through needle Injector: </strong>Volume range of 0.1 to 1000 μL and ultra-low carryover performance compatible with sensitive LC-MS applications.</li><li><strong>High Performance Surfaces Technology: </strong>With MaxPeak HPS Technology, analytes are impeded from Lewis acid-base interactions and adsorptive losses. This technology has proven to be effective in improving the analysis of electron-rich compounds, such as those containing phosphate and carboxylate groups.</li><li><strong>Consumables: </strong>Compatible with MaxPeak Premier Column chemistry to meet the needs of your reversed-phase and HILIC applications. Quality Control (QC) Reference Material benchmarks your Arc Premier System and enables perfect resolution. <strong>Certified clean </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/197"><strong>QuanRecovery™ vials</strong></a> to give full sample integrity.</li><li><strong>High performance analytical detectors : </strong>A wide range of high-performance detection capabilities, optimized with HPS, to support diverse applications. Includes photodiode array, UV/Vis, and fluorescence, with the additional option of single and triple quad mass detection.</li><li><strong>Solvent blending: </strong>Quaternary or binary solvent mixing. Delivers precise and accurate separations at pressures up to 9500 psi. Optional solvent select valve adds access to additional solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision, and reliability.</li><li><strong>Auto•Blend Plus Technology: </strong>Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</li><li><strong>Gradient SmartStart: </strong>Adjust the injection relative to the gradient start to emulate other HPLC systems’ dwell volumes, without the need to alter the gradient table. Successfully transfer most methods in just two injections.</li><li><strong>Laboratory Informatics: </strong>Software control within your existing <strong>Empower </strong>or <strong>MassLynx™ </strong>infrastructure. Empower Method Validation Manager (MVM) allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_3_5db411b90a.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_3_5db411b90a.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div></div></div><div><div><div><div><div><div><h3><strong>The Universal Platform for Liquid Chromatography</strong></h3><p>Non-specific adsorption of metal-sensitive compounds is an unpredictable challenge, resulting in chromatography with large relative standard deviations (RSDs) and broad, overlapping peaks, which can be challenging to integrate quickly and be accurate consistently.</p><p>Designed with MaxPeak HPS Technology and paired with <strong>MaxPeak Premier 2.5 μm Columns</strong>, the Arc Premier System improves data quality for challenging compounds, including metal-sensitive compounds tested with LC methods – so you can see clearly and consistently, with confidence.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_8_a4038daa52.jpg" alt="Waters Arc Premier LC System: Figure 1. Analysis of adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate. Significant improvements to sensitivity and recovery are observed with the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_8_a4038daa52.jpg 245w," sizes="100vw" width="1123" height="520"></p></div></div></div></div></div></div></div></div><div><div><h3><strong>Clear</strong></h3><p>Future-proof your lab for the next generation of challenging compounds with MaxPeak HPS Technology, which sharpenspeaks for metal-sensitive compounds, resulting in higher data quality and improved sensitivity with chromatographic reproducibility and precision.</p><p>Data quality and performance are <strong>critical </strong>for your lab, but those can’t come at the sacrifice of ruggedness and ease of use.&nbsp;</p><p>With MaxPeak HPS Technology and flexible LC performance, your lab gets the typical benefits of an LC system optimized for <strong>2.x μm column chemistry </strong>with the MaxPeak HPS Technology’s ability to shorten run times and achieve sharp peaks - no lengthy and complex conditioning and conditioning methodologies for metal-sensitive compounds required.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_9_34ec4befec.jpg" alt="Waters Arc Premier LC System: Figure 2. Analysis of adenosine triphosphate. Lower limits of detection and increased calibration curve linearity are demonstrated with the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_9_34ec4befec.jpg 245w," sizes="100vw" width="940" height="523"></p></div></div><div><div><h3><strong>Consistent</strong></h3><p>Seeing your results more clearly than ever is critical, but those results must be consistent and error-free and your methods easily reproducible, so you can spend less time on analysis and ensure compliance.&nbsp;</p><p>By <strong>significantly sharpening peak shapes</strong> for metal-sensitive analytes, scientists report an improvement in %RSD when integrating data from metal-sensitive compounds on the Arc Premier System. Along with the improvement in data consistency users also report a decrease of time needed to integrate peaks by <strong>approximately 30%</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_f80500f8a4.jpg" alt="Waters Arc Premier LC System: Figure 3. Analysis of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate. Peak heights increased and peak shapes are more symmetrical for metal- sensitive compounds on the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_f80500f8a4.jpg 235w," sizes="100vw" width="1381" height="918"></p><p>The Arc Premier System <strong>eliminates </strong>the need for<strong> variability-prone conditioning and complex mobile phases</strong> – so you can minimize user errors, improve compliance, and reduce expensive audits from red flag-inducing conditioning injections.</p><p>Your organization needs to reliably migrate higher-quality methods between your systems for maximum reproducibility. With MaxPeak HPS Technology and flexible pump configurations, your lab can easily, reliably <strong>migrate methods between MaxPeak HPS-based systems </strong>quickly, saving you time and money from unnecessary rework. You can also<strong> migrate methods from non-MaxPeak HPS-enabled systems </strong>safely, as method performance of non-metal-sensitive compounds have been shown to not be adversely affected.</p><p>Combining higher data quality with ease of use for your analysts and seamless method transfer, enables results that can be generated consistently between runs and with various analysts.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_6_5332aab31f.jpg" alt="Waters Arc Premier LC System: Figure 4. Analysis of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate. A zoom in on the baseline shows improved peak shapes and resolution for metal-sensitive compounds on the Arc Premier Solution compared to a conventional LC system, improving baseline resolution." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_6_5332aab31f.jpg 229w," sizes="100vw" width="1380" height="942"></p><h3><strong>Confident</strong></h3><p><strong>Reducing analytical uncertainty and achieving peace</strong> of mind are important for your organization. With MaxPeak HPS Technology, metal-sensitive analytes become visible that were previously undetectable. This allows you to quickly and confidently know that you’ve seen everything in your sample, giving you the confidence to stand behind your data-driven decisions.</p><p>The <strong>combination of MaxPeak HPS Technology, flexible pump and column management options, and precise optical and MS detection</strong> give you the method development and verification capabilities to know that no matter the sample - you can deliver a robust method you can stand behind.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_2_85f2f7cc29.jpg" alt="Waters Arc Premier LC System: Figure 5. Analysis of data of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate from an Arc Premier System and a conventional LC system by six users. Peak area reproducibility improved 9 – 124x when integrating the same data from metal-sensitive compounds across six users." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_2_85f2f7cc29.jpg 239w," sizes="100vw" width="1243" height="810"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_5_514749f32d.jpg" alt="Waters Arc Premier LC System: Figure 6. Analysis of acetaminophen, caffeine, leucine enkephalin, sulfadimethoxine, amitriptyline, reserpine, and terfenadine shows that non-metal-sensitive compounds demonstrate comparable performance between the Arc Premier Solution and conventional LC systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_5_514749f32d.jpg 245w," sizes="100vw" width="1242" height="735"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_7_edc8ecaa93.jpg" alt="Waters Arc Premier LC System: Figure 7. Comparison of adenosine triphosphate and adenosine diphosphate peaks using a conventional LC system and the Arc Premier Solution over 120 injections. The peak areas of metal-sensitive compounds remain constant from the first to the 120th injection using the Arc Premier Solution. Peak areas of metal-sensitive compounds on a conventional LC system continuously increase over time and do not stabilize even after 120 injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_7_edc8ecaa93.jpg 218w," sizes="100vw" width="1038" height="744"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_3_f1cca337bc.jpg" alt="Waters Arc Premier LC System: Figure 8. Comparison of adenosine triphosphate and adenosine diphosphate peaks using a conventional LC system and the Arc Premier Solution over 120 injections. The peak areas of metal-sensitive compounds remain constant from the first to the 120th injection using the Arc Premier Solution showing less than a 1% change in peak area for all compounds. Peak areas of metal-sensitive compounds on a conventional LC system show an increase of 2–35% when compared to the first injection and show no signs of stabilization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_3_f1cca337bc.jpg 216w," sizes="100vw" width="1039" height="750"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_4_1dae3909ae.jpg" alt="Waters Arc Premier LC System: Figure 9. Adenosine triphosphate, adenosine diphosphate, adenosine monophosphate, and adenosine stability using the Arc Premier Solution over 1000 injections. The peak areas of metal-sensitive compounds remain consistent over 1000 injection using the Arc Premier Solution demonstrating the robustness of the system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_4_1dae3909ae.jpg 243w," sizes="100vw" width="1040" height="669"></p></div></div></div></div>

Products from category UHPLC from Waters distributed by Waters Corporation (Europe) - page 1

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