<p><strong>A nitrogen-enriched graphene nanomaterial (GN3) for energy storage in supercapacitors, developed by researchers at the Czech Advanced Technology and Research Institute (CATRIN) of Palacký University Olomouc, has been included in the European Commission’s </strong><a target="_blank" rel="noopener noreferrer" href="https://innovation-radar.ec.europa.eu/innovation/66621"><strong>Innovation Radar database as a technology with strong commercial potential</strong></a><strong>. The material has been assessed as highly market-ready, with significant potential to create new markets. Palacký University, which coordinated the prestigious European Innovation Council project TRANS2DCHEM, has also been recognised among the project’s key innovators.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Grafenovy_material_z_Olomouce_se_dostal_mezi_perspektivni_evropske_inovace_0d2a178219.jpg" alt="CATRIN: Graphene nanomaterial developed in Olomouc recognised among Europe’s most promising innovations" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Grafenovy_material_z_Olomouce_se_dostal_mezi_perspektivni_evropske_inovace_0d2a178219.jpg 156w," sizes="100vw" width="480" height="480"></p><p>Innovation Radar is a European platform that identifies promising innovations and key innovators emerging from research and innovation projects funded by the European Union.</p><p>“This is a great honour and recognition of our work. The excellent assessment within the Innovation Radar platform demonstrates the potential of CATRIN—and of Palacký University as a whole—to transform scientific discoveries into products with strong commercial potential. Recognition by independent experts highlights the technology’s high level of market readiness, which is exceptional even in the context of other outstanding projects supported by the European Innovation Council,” said <strong>Jiří Navrátil, Technology Transfer Coordinator at CATRIN</strong>.</p><p>The nitrogen-enriched graphene electrode material, based on graphene—a two-dimensional material consisting of a single layer of carbon atoms—was developed by researchers in Olomouc seven years ago. It originated from <strong>Michal Otyepka’s</strong> prestigious European Research Council project focused on the <strong>2D chemistry of fluorographene</strong>.</p><p>In the following years, researchers demonstrated the material’s significant potential for electrical energy storage, particularly in supercapacitors, which represent a promising alternative to today’s widely used lithium-ion batteries. Development of prototype supercapacitors with unique properties began under the prestigious European Innovation Council project <strong>TRANS2DCHEM</strong>, in collaboration with partners from<strong> Bar-Ilan University in Israel</strong> and the<strong> Italian company ITELCOND</strong>. The next logical step was the establishment of the spin-off company <strong>Atomiver</strong>, which has been operating since 2024.</p><p>“The continuous growth in global energy consumption and the rapid expansion of electronic devices are driving strong demand for high-performance, stable energy storage components. Our electrode material is unique because it pushes the current limits of commercially available technologies, particularly in terms of volumetric energy density—the amount of electrical energy that can be stored within a given volume. Compared with existing technologies, our material enables several-fold higher energy density. Its inclusion in the Innovation Radar database encourages us to continue developing the technology and bring it closer to commercial production,” said <strong>Michal Otyepka</strong>, one of the inventors of the technology and co-owner of the spin-out company.</p><p>The material is protected by <strong>several international patents</strong>, which have been licensed by Atomiver from Palacký University.</p><p>“Supercapacitors incorporating our graphene material could one day help ensure the safe operation of large data centres, Internet of Things (IoT) networks, transport systems, grid-scale energy storage, electronics for space applications and implantable medical devices,” added<strong> Veronika Šedajová</strong>, one of the inventors of the technology.</p><p>The significance of the technology was previously recognised when Atomiver was selected for the<strong> NATO DIANA </strong>accelerator programme, one of only<strong> 74 companies chosen from more than 2,600 applicants</strong>. The company has also received support from CzechInvest through its Technology Incubation programme.</p><p>“We are currently in intensive discussions with investors, who have shown strong interest in the technology, not least because the electrode material we have developed also has considerable potential for applications in other industries,” said<strong> Andrew Hladký, Director of Atomiver</strong>.</p><p><a target="_blank" rel="noopener noreferrer" href="https://innovation-radar.ec.europa.eu/innovation/66621"><strong>Innovation Radar</strong></a> serves as a platform for investors, entrepreneurs and the wider public to discover emerging technologies.</p>

Graphene nanomaterial developed in Olomouc recognised among Europe’s most promising innovations

<h3><strong>HPLC Detection Technologies: A Practical Overview</strong></h3><p><strong>High-performance liquid chromatography is a cornerstone of modern analytical chemistry. It is routinely applied in pharmaceutical quality control, biopharmaceutical development, environmental monitoring, food analysis, and polymer characterization. However, separating the components of a sample is only one part of the analytical process. The compounds leaving the column must also be recognized and converted into a signal that can be evaluated.</strong></p><p>This is the task of the HPLC detector. Its selection can strongly influence the sensitivity, selectivity, reliability, and overall usefulness of a chromatographic method.</p><p>In the first article of our HPLC detector series, we introduce the principal detection technologies, explain how they differ, and outline the factors that should be considered when selecting a detector for a particular application.</p><h4><strong>What Does an HPLC Detector Do?</strong></h4><p>After compounds have been separated inside the chromatographic column, they enter the detector one after another. The detector continuously monitors the column effluent and responds to a physical or chemical property of each analyte.</p><p>This response is converted into an electrical signal and displayed as a chromatogram. The position of a peak provides information related to retention time, while its height or area can be used to determine the amount of the corresponding compound.</p><p>A detector must therefore provide more than a visible signal. It should generate data that are sufficiently sensitive, stable, reproducible, and suitable for the purpose of the analytical method.</p><p>Several characteristics are particularly important when comparing detector technologies:</p><ul><li><strong>Sensitivity:</strong> The lowest amount or concentration that can be detected or reliably quantified.</li><li><strong>Selectivity:</strong> The ability to respond preferentially to certain compounds while minimizing signals from other sample components.</li><li><strong>Linearity and working range:</strong> The concentration interval over which detector response remains proportional to analyte concentration.</li><li><strong>Mobile-phase compatibility:</strong> The detector must function correctly with the selected solvents, additives, gradients, flow rates, and temperatures.</li><li><strong>Information content:</strong> Some detectors provide only a quantitative response, while others also deliver spectral or structural information.</li><li><strong>Practical requirements:</strong> Instrument cost, maintenance, method complexity, and operator experience must also be considered.</li></ul><p>There is consequently no single detector that is ideal for every separation. The most suitable choice depends on the analyte, sample matrix, expected concentration, mobile phase, and type of information required.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_Typical_HPLC_system_configuration_with_two_detectors_d909b878b2.webp" alt="KNAUER: Figure 1 - Typical HPLC system configuration with two detectors." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_Typical_HPLC_system_configuration_with_two_detectors_d909b878b2.webp 245w," sizes="100vw" width="1024" height="531"></p><h4><strong>How HPLC Detector Responses Can Be Classified</strong></h4><p>HPLC detection principles can be viewed from three broad perspectives.</p><h5><strong>Analyte-property detection</strong></h5><p>These detectors respond to a characteristic of the individual compound, such as UV absorption, fluorescence, optical activity, or electrochemical behavior. Their response may therefore be highly selective, but only analytes possessing the relevant property can be measured.</p><h5><strong>Bulk-property detection</strong></h5><p>Bulk-property detectors monitor a change in a general physical property of the mobile phase as an analyte passes through the detector. Refractive index is a common example. Because many compounds can produce such a change, these detectors offer broad applicability, although they are often less sensitive and more dependent on stable operating conditions.</p><h5><strong>Hyphenated detection techniques</strong></h5><p>In hyphenated systems, HPLC is connected to another analytical technology capable of generating additional information. Liquid chromatography–mass spectrometry is the best-known example. These combinations extend detection beyond a simple chromatographic response and can provide molecular-mass or structural data.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Table_1_Common_HPLC_Detectors_8b54ef057f.webp" alt="KNAUER: Table 1 - Common HPLC Detectors." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Table_1_Common_HPLC_Detectors_8b54ef057f.webp 245w," sizes="100vw" width="1024" height="228"></p><h4><strong>1. Optical Detectors</strong></h4><p>Optical detection is the most established and widely used approach in routine liquid chromatography. These detectors evaluate how an analyte absorbs, emits, rotates, or otherwise interacts with light.</p><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=175&amp;manufacturerItems=503"><strong>UV/VIS</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=177&amp;manufacturerItems=503"><strong>DAD, and PDA detectors</strong></a></h5><p>UV/VIS absorbance detectors measure the reduction in light intensity caused by an analyte at a selected wavelength. They are especially suitable for compounds containing chromophores, which are molecular structures capable of absorbing ultraviolet or visible light.</p><p>Diode-array and photodiode-array detectors record absorbance across a broader wavelength range. In addition to quantitative detection, they can provide spectral information that assists with wavelength selection, peak comparison, and the assessment of chromatographic purity.</p><p>UV-based detectors are popular because they are robust, relatively easy to operate, and compatible with a wide range of routine HPLC applications.</p><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=297&amp;manufacturerItems=503"><strong>Fluorescence detectors</strong></a></h5><p>Fluorescence detection measures light emitted by a compound after excitation at a specific wavelength. It can provide excellent sensitivity and selectivity when an analyte is naturally fluorescent.</p><p>Compounds without native fluorescence may sometimes be converted into fluorescent derivatives before or after separation. This extends the range of applications but introduces an additional sample-preparation or reaction step.</p><p>Fluorescence detection is frequently used for pharmaceutical compounds, environmental contaminants, biological molecules, and other analytes requiring sensitive measurement in complex samples.</p><h5><strong>Optical rotation and circular dichroism detectors</strong></h5><p>These detectors evaluate the interaction of optically active compounds with polarized light. They are particularly valuable in chiral separations, where the objective is to distinguish between enantiomers and evaluate enantiomeric purity.</p><p>Their application is more specialized than conventional UV detection, but they can provide information that cannot be obtained from a standard absorbance signal alone.</p><h4><strong>2. Aerosol and Light-Scattering Detectors</strong></h4><p>Some analytes do not absorb UV light strongly enough for reliable absorbance detection. Aerosol-based and light-scattering technologies provide alternatives for many nonvolatile compounds.</p><h5><strong>Evaporative light-scattering detection</strong></h5><p>In an evaporative light-scattering detector, the column effluent is nebulized and the volatile mobile phase is removed. The remaining analyte particles pass through a light beam, and the scattered light is measured.</p><p>ELSD can therefore detect many compounds that lack chromophores, including certain lipids, carbohydrates, surfactants, and polymers. The analyte must generally be less volatile than the mobile phase.</p><h5><strong>Charged aerosol detection</strong></h5><p>Charged aerosol detection also begins with nebulization and evaporation of the mobile phase. The resulting analyte particles are then electrically charged, and the charge is measured to generate the detector response.</p><p>CAD offers broad applicability for nonvolatile and semi-volatile analytes and is frequently considered when UV detection is unavailable or produces an insufficient response.</p><h5><strong>Multi-angle light scattering</strong></h5><p>Multi-angle light-scattering detectors measure light scattered at several angles. When combined with suitable chromatographic and concentration data, MALS can support the characterization of molecular size and absolute molar mass.</p><p>This capability is particularly valuable in polymer analysis, protein characterization, and size-exclusion chromatography.</p><h4><strong>3. Mass Spectrometric Detection</strong></h4><p>Mass spectrometry is among the most informative detection technologies available for liquid chromatography. Instead of responding only to absorbance or another general property, an MS detector measures ions according to their mass-to-charge ratio.</p><p>LC–MS can provide:</p><ul><li>High sensitivity for trace-level analysis</li><li>Strong selectivity in complex sample matrices</li><li>Molecular-mass information</li><li>Fragmentation data supporting compound identification</li><li>Qualitative and quantitative results within a single workflow</li></ul><p>Mass spectrometry is not universal in the strictest sense because the analyte must be successfully ionized. The mobile phase and its additives must also be compatible with the ion source.</p><p>Despite these requirements, LC–MS has become indispensable in pharmaceutical research, clinical and bioanalytical testing, food safety, environmental analysis, metabolomics, and many other fields. Its main disadvantages are higher acquisition costs, greater method complexity, and more demanding maintenance and data interpretation.</p><h4><strong>4. Electrochemical Detectors</strong></h4><p>Electrochemical detectors measure electrical changes associated with oxidation or reduction reactions at an electrode surface. They are suitable for compounds that are electrochemically active under the selected conditions.</p><p>Typical applications include the analysis of:</p><ul><li>Neurotransmitters</li><li>Catecholamines</li><li>Vitamins</li><li>Phenolic compounds</li><li>Redox-active pharmaceutical substances</li></ul><p>For suitable analytes, electrochemical detection can achieve very high sensitivity and selectivity. At the same time, reliable operation requires carefully controlled mobile-phase composition, clean solvents, stable electrode conditions, and thorough method optimization.</p><p>The technique is therefore extremely powerful for targeted applications but less broadly applicable than UV or mass spectrometric detection.</p><h4><strong>5. Bulk-Property and Specialized Detectors</strong></h4><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2429"><strong>Refractive index detectors</strong></a></h5><p>A refractive index detector compares the refractive index of the mobile phase with that of the mobile phase containing an eluting analyte. Because many compounds alter this property, RID can be used for substances that do not absorb UV light.</p><p>Common applications include sugars, alcohols, lipids, and polymers. Refractive index detection is relatively straightforward, but it generally provides lower sensitivity than UV or fluorescence detection. It is also highly sensitive to changes in temperature and mobile-phase composition, making it poorly suited to gradient elution.</p><h5><strong>Viscosity and pH detectors</strong></h5><p>Viscosity detectors monitor changes in the flow characteristics of the mobile phase, while pH detectors respond to changes in acidity or alkalinity. These technologies are less common in general-purpose HPLC but can be useful in specific analytical or characterization workflows.</p><h5><strong>Radioactivity detectors</strong></h5><p>Radioactivity detectors are used when compounds contain radioactive labels. They are particularly important in tracer studies, metabolism research, drug development, and nuclear medicine.</p><p>Their selectivity is determined by the radioactive signal, allowing labelled compounds and their products to be followed even in complex matrices.</p><h4><strong>Selecting the Most Appropriate Detector</strong></h4><p>The detector should be selected according to the analytical question rather than according to a single performance specification.</p><p>For routine analysis of compounds with suitable chromophores, UV or diode-array detection is often the most practical solution. Fluorescence or electrochemical detection may be preferable when very high sensitivity is required for compounds with the appropriate chemical properties.</p><p>ELSD and CAD are useful for nonvolatile analytes that exhibit weak or no UV absorption. Refractive index detection remains valuable for relatively concentrated samples analyzed under isocratic conditions. When molecular identification, structural confirmation, or highly selective trace analysis is required, mass spectrometry is usually the strongest option.</p><p>In more complex workflows, several detectors may be connected in sequence. This makes it possible to obtain complementary information from the same chromatographic separation.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Detector_types_used_in_HPLC_b64aecb606.webp" alt="KNAUER: Figure 2 Detector types used in HPLC." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Detector_types_used_in_HPLC_b64aecb606.webp 245w," sizes="100vw" width="1024" height="346"></p><h4><strong>Conclusion</strong></h4><p>A successful chromatographic separation must be paired with a detector capable of revealing the compounds of interest. Detector selection directly affects what can be measured, at what concentration, and with what degree of confidence.</p><p>Understanding the underlying detection principles makes it easier to balance sensitivity, selectivity, compatibility, information content, and practical laboratory requirements. Rather than searching for a universally superior technology, analysts should choose the detector whose response best matches the properties of the analyte and the objective of the method.</p><p>The next article in this series will examine detector performance in greater detail, including the specifications and evaluation criteria that make it possible to compare different technologies more fairly.</p>

Seeing is Believing – Detection Made Easy Part 1: Detector Overview

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 10th August 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you posters by <strong>Agilent Technologies / ASMS, Thermo Fisher Scientific / ASMS </strong>and<strong> Waters Corporation / ASMS </strong>and application notes by<strong> Metrohm and Shimadzu!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Impurity Monitoring of GLP-1 Therapeutic Peptide RetatrutideUsing a 2D-LC/TOF System</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/glp_1_impurity_monitoring_2d_lc_tof_asms_2026_mp_388_agilent_eadce3f244.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Retatrutide is a next-generation triple agonist (GLP1/GIP/glucagon) and an emerging candidate among multivalent GLP1–based therapeutics. Its structural complexity and diverse impurity profile challenge conventional one-dimensional LC methods, which often lack sufficient resolving power to separate closely related impurities, sequence variants, and synthetic byproducts.&nbsp;</p><p>In this study, we demonstrate an Agilent multiple heart-cutting 2D-LC platform that enables rapid online solvent exchange and enhanced chromatographic selectivity, allowing targeted isolation of impurity peaks from a TFA-based first-dimension separation. When coupled with the Agilent 6230C Accurate Mass TOF LC/MS system, the workflow delivers fast, sensitive, and accurate mass profiling under MS-friendly second-dimension conditions, providing a robust solution for comprehensive impurity characterization of GLP-1 peptides such as Retatrutide.</p><h4><strong>Experimental</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=39&amp;mainauthorItems=10&amp;search=1290+infinity+III+2D-LC"><strong>Agilent 1290 Infinity III 2D-LC system</strong></a><strong> comprised the following modules:&nbsp;</strong><ul><li>1290 Infinity III Bio Multisampler with Thermostat (G7137A)&nbsp;</li><li>1290 Infinity III Multicolumn Thermostat (G7116B)&nbsp;</li><li>1290 Infinity III Diode Array Detector (G7117B) with Max-Light cartridge cell (G7117-60020)&nbsp;</li><li>1260 Infinity III Bio Flexible Pump (G7131C)&nbsp;</li><li>1290 Infinity III Bio High-speed Pump (G7132A)&nbsp;</li><li>1290 Infinity Valve Drive (G1170A) with 2D-LC ASM Valve (G5643B)&nbsp;</li><li>Two 1290 Infinity III Valve Drives (G1170A) with multiple heart-cutting valves (G5642-64000) equipped with 40 µL Bio loops&nbsp;</li></ul></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=6230C"><strong>Agilent 6230C Accurate Mass TOF LC/MS System</strong></a></li></ul><h4><strong>Conclusions</strong></h4><p>Agilent 2D-LC with multiple heart-cutting effectively bridges TFA-driven chromatographic performance with FA-compatible MS detection, overcoming ion suppression limitations.&nbsp;</p><p>The integrated 2D-LC/Accurate Mass TOF workflow delivers confident impurity identification and robust characterization, supporting peptide analysis in both QA/QC and development environments.</p><h3><strong>2. Metrohm: Vinylene carbonate water determination via coulometric Karl Fischer titration</strong></h3><p><strong>Water determination in vinylene carbonate by Karl Fischer coulometric titration made simple with alcohol-free reagents</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_k_076_download_8658665940.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Vinylene carbonate (vc) is commonly used as a battery electrolyte additive in lithium-ion batteries. Its popularity is due to the positive impact it has on anode cyclability and reduction of irreversible capacity. Small amounts of moisture in Li-ion batteries can significantly decrease performance and lifetime. Therefore, moisture levels in electrolyte solutions and their additives are controlled for use in manufacturing. Until recent years, accurate moisture quantification in vinylene carbonate samples was difficult due to side reactions. With the commercial development of alcohol-free coulometric Karl Fischer reagents, accurate determination is now much more accessible to end-users.</p><h4><strong>EXPERIMENTAL</strong></h4><p>This analysis was performed using an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=220&amp;search=852+titrando"><strong>852 Titrando</strong></a> (2.852.0060) instrument, equipped with the electrodes listed in Table 1.</p><h4><strong>CONCLUSION&nbsp;</strong></h4><p>During battery manufacturing, control of all moisture present is important to guarantee adequate performance in the finished product. More easily quantifying the moisture contribution from additives such as vinylene carbonate makes this a much simpler task. The introduction of alcohol-free Karl Fischer reagents accomplishes this effectively, allowing the generation of accurate and repeatable moisture data—even for a difficult sample matrix.</p><h3><strong>3. Shimadzu: Non-Targeted Analysis of Metabolites in Alcoholic Beverages Using LabSolutions Insight Profiler</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01241_en_57b43edb57.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Using an LC-QTOFMS system with LabSolutions Insight Profiler non-targeted analysis software enables comprehensive comparative analysis of metabolites in food samples.&nbsp;</li><li>Principal component analysis and volcano plots can be used to detect characteristic features in each sample.&nbsp;</li><li>A variety of functions, including MS/MS spectral library searching, enable easy qualitative analysis of components.</li></ul><p>Metabolomics, a technique that analyzes metabolites in living organisms, is increasingly being applied in the food industry for product development and quality control. A particularly powerful approach is non-targeted metabolomics, which aims to analyze not only known metabolites but also unknown compounds without prior assumptions to reveal unexpected chemical differences between samples. Quadrupole time-of-flight mass spectrometry (QTOFMS), with its accurate-mass capability, is well suited for this purpose. However, the large volume of generated data creates challenges for feature identification and data comparison.&nbsp;</p><p>This article presents a case study in which LabSolutions Insight Profiler, a software platform for non-targeted analysis, was used to characterize compounds in beer and beer-like beverages. Peak detection, retention-time alignment, and library searching were performed across multiple datasets. Multivariate analysisrevealed compound profiles that likely reflect the differences in raw materials and manufacturing processes, demonstrating the utility of the approach for beverage characterization.</p><h4><strong>LabSolutions Insight Profiler&nbsp;</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=LabSolutions+Insight+Profiler"><strong>LabSolutions Insight Profiler </strong></a>is software for batch processing of LC-QTOFMS data that enables non-targeted analysis through an intuitive workflow. It readily supports easy spectral feature detection, alignment, statistical processing, filtering, list screening, MS/MS spectra-based library searching, principal component analysis (PCA), displaying volcano or box plots, and more. Fig. 1 shows the data analysis workflow.</p><h4><strong>Analysis Conditions&nbsp;</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=nexera+X3"><strong>Nexera X3 UHPLC</strong></a> and<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=9030"><strong>LCMS-9030 systems</strong></a> were used as the analytical instruments. The LC method included in the LC/MS/MS Method Package for Primary Metabolites was used as the method. The data-dependent acquisition (DDA) mode was used to simultaneously acquire precursor m/z and MS/MS data. Table 2 shows the analysis conditions.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>In this study, compounds in various beer and beer-like beverages were analyzed by non-targeted analysis using an LCMS-9030 quadrupole time-of-flight mass spectrometer system. Analyzing compounds characteristic of each sample with LabSolutions Insight Profiler software confirmed that the resulting profiles reflected differences in raw materials and manufacturing methods.&nbsp;</p><p>LabSolutions Insight Profiler enables efficient non-targeted analysis by processing LC-QTOFMS data with an intuitive workflow. This workflow allows for objective evaluation of the taste, quality, and nutritional value of food products. Furthermore, this method is applicable not only to the analysis of compounds in beverages but also to non-targeted analysis of other types of samples.</p><h3><strong>4. Thermo Fisher Scientific / ASMS: High throughput targeted proteomic workflows with Adaptive Retention Time on the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1959"><strong>Orbitrap Astral Zoom MS</strong></a></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_004699_lsms_art_astral_zoom_proteomics_po004699_asms2026_na_en_78767efdc9.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Advances in MS instrumentation have accelerated the identification of biomarkers, but validating and translating these discoveries into assays for clinical use remains challenging and typically requires robust and accurate targeted approaches. While these often rely on predetermined reference target retention time (RT) windows, analytical column degradation or replacement, aging solvents, sample matrix effects, etc. can cause peptide RT shifts between injections and across longer-term analyses. To accommodate this, targeted MS experiments generally schedule wide target RT windows (&gt;1 min) or rely on heavy labeled peptides to trigger acquisition of endogenous peptides. Both greatly limit the number of quantifiable targets per assay. To overcome this, we utilize adaptive RT (aRT) alignment for live correction of RTs together with the speed and sensitivity of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1959"><strong>Orbitrap Astral Zoom MS</strong></a>. This allows reproducible tracking of &gt;2000 targets with narrow RT windows, high throughputs, such as 300 samples per day (SPD), and hybrid workflows combining targeting, of up to 1000 targets, and discovery.</p><h4><strong>Materials and methods&nbsp;</strong></h4><h5><strong>LC-MS Experiments&nbsp;</strong></h5><p>Experiments were performed using Thermo Scientific Pierce HeLa protein digest resuspended in 0.1% TFA, or individual or pooled human plasma samples. Peptides were separated using a 15 cm Thermo Scientific PepMap analytical columns (150 µm inner diameter) and the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/398"><strong>Thermo Scientific Vanquish Neo UHPLC system</strong></a> at throughputs of 60 or 300 SPD. The liquid chromatography (LC) system was interfaced with the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1959"><strong>Orbitrap Astral Zoom MS.</strong></a> Reference runs using MS1 and/or data-independent-acquisition (DIA) scans were acquired to obtain reference aRT spectra, and to determine target RTs. For aRT alignment, methods consisting of aRT MS1 and/or DIA scans, as well as targeted MS2 scans with RT correction were optimized. For hybrid DIA workflows, we used aRT MS1 scans for reference acquisition and alignment, combined with narrow window DIA and a targeted MS2 experiment. Observed RT shifts were caused by natural column degradation, sample matrix effects or when indicated induced by variation in gradient flow rate and buffer composition.&nbsp;</p><h5><strong>Data analysis&nbsp;</strong></h5><p>Reference DIA data was analyzed using Spectronaut. Targets lists were then generated from the search output by selecting varying number of targets evenly distributed across the RT dimension. Target RTs for smaller scale assays were manually validated and exported from Skyline, while target RTs for large scale assays were exported from Spectronaut. For alignment runs, DIA and PRM data were analyzed using Spectronaut and Skyline respectively.</p><h4><strong>Conclusions&nbsp;</strong></h4><ul><li>Adaptive RT alignment on Orbitrap Astral Zoom MS shows robustness against various sources of RT shifts and has high target recovery even for thousands of targets&nbsp;</li><li>aRT enables the use of target acquisition windows &lt;15 s for robust targeting at high throughput&nbsp;</li><li>aRT Hybrid DIA allows targeting of up to 1000 targets with minimal cost to DIA depth</li></ul><h3><strong>5. Waters Corporation / ASMS: BOOSTING SENSITIVITY IN TOP-DOWN PROTEIN STUDIES USING CYCLIC IMS-ENABLED WIDEBAND ENHANCEMENT</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009471_51f2e8b546.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><p>The poster evaluates <strong>Wideband Enhancement (WBE)</strong> as a way to improve sensitivity in top-down protein mass spectrometry. In top-down workflows, intact proteins are fragmented directly, but the signal is distributed across multiple charge states, isotope envelopes, and numerous product ions, which can limit MS/MS sensitivity. WBE addresses this problem by synchronizing ion packets leaving the ion mobility region with the time-of-flight pusher, thereby increasing the number of ions that reach the detector within a selected <i>m/z</i> range.</p><p>Experiments were performed using a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2434"><strong>Waters Cyclic IMS P20 Mass Spectrometer</strong></a> equipped with an <strong>electron capture dissociation cell</strong>. Samples were introduced by direct infusion in positive electrospray ionization mode. Two proteins were studied under denaturing conditions: bovine ubiquitin, approximately 8.5 kDa, and bovine carbonic anhydrase II, approximately 29 kDa. Single-pass and bypass ion mobility measurements were carried out with and without WBE, using both <strong>collision-induced dissociation (CID)</strong> and <strong>electron capture dissociation (ECD)</strong>. Data were acquired in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635"><strong>MassLynx</strong></a><strong> v4.2</strong> and processed using <strong>DriftScope</strong> and the <strong>waters_connect UNIFI peptide-mapping workflow</strong>.</p><p>For ubiquitin, WBE substantially increased the intensity of CID- and ECD-derived fragment ions. Improvements of up to tenfold were observed across the c- and z-ion series, while bypass ion mobility mode produced the largest overall sensitivity gain. The results indicate that WBE can enhance fragment detection while retaining the benefits of cyclic ion mobility separation and without sacrificing mass-spectral resolution.</p><p>The larger carbonic anhydrase II protein also showed marked improvements. CID fragment signals increased by up to tenfold for lower-<i>m/z</i> ions and about eightfold for higher-<i>m/z</i> fragments. Because ECD is generally less efficient than CID, the benefit of WBE was especially evident in ECD experiments: sequence coverage increased from <strong>54% without WBE to 70% with WBE</strong> in bypass mode. The authors conclude that combining WBE with complementary CID and ECD fragmentation on the Cyclic IMS P20 enables more sensitive and comprehensive top-down protein characterization.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 33, 2026

Article

Product

Application

Academy

Science and research

Poster

The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Characterization of polymers (Watrex)

Watrex Prague offers laboratory characterization of polymers using GPC.

<h4><strong>WI08112 – Determination of Molecular Weight Distribution of Polymeric Materials</strong></h4><ul><li>Determination by GPC method in water and THF, or optionally in other solvents upon request.</li><li>Each set of measurements requires calibration (WI08113).</li><li><strong>Price:</strong> 3,300 CZK excl. VAT</li></ul><h4><strong>WI08113 – Calibration for Molecular Weight Distribution of Polymeric Materials</strong></h4><ul><li>Calibration using dextran, polymaltotriose, or polystyrene standards for GPC molecular weight distribution determination.</li><li><strong>Price:</strong> 4,500 CZK excl. VAT</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_GPC_separace_polymeru_na_kolone_Watrex_Delta_Gel_47ce92deaa.jpg" alt="Watrex: GPC separation of polymers on Watrex DeltaGel column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_GPC_separace_polymeru_na_kolone_Watrex_Delta_Gel_47ce92deaa.jpg 213w," sizes="100vw" width="1385" height="1018"></p><blockquote><h3><strong>Services – Laboratory</strong></h3><p>The <strong>Watrex Analytical Laboratory</strong> will be happy to perform any of our standard analyses, custom analyses, or assist you with <strong>method development</strong>.</p><p>We specialize primarily in <strong>liquid chromatography techniques</strong> and are ready to meet a wide range of requirements—from <strong>method development and optimization</strong>, through <strong>validation and verification of external methods</strong>, to <strong>training and troubleshooting</strong>.</p><p>Our laboratory also <strong>manufactures and packs its own chromatographic columns and guard columns</strong> for basic HPLC modes (<strong>reversed phase, normal phase, ion chromatography, and ion exclusion chromatography</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637"></p></blockquote>

Analytical Services for Building Materials (Watrex Laboratory)

Comprehensive analysis of building materials by ion chromatography and gravimetry – salts, moisture, lime, gypsum, density, and absorption testing by Watrex Laboratory.

<h5><strong>WI08101 – Determination of Water-Soluble Salts in Building Materials</strong></h5><ul><li>Determination of chlorides, nitrates, and sulfates in aqueous extract using ion chromatography. Requires approx. 1 g of a homogeneous sample.</li><li><strong>Price:</strong> 600 CZK excl. VAT</li></ul><h5><strong>WI08102 – Determination of Moisture in Building Materials</strong></h5><ul><li>Gravimetric method after drying the sample to constant weight. Moisture content is expressed in mass %. Requires at least 10 g of sample in sealed packaging.</li><li><strong>Price:</strong> 300 CZK excl. VAT</li></ul><h5><strong>WI08103 – Determination of Lime Content in Lime Mortars</strong></h5><ul><li>After acid digestion, Ca and Mg content is determined to calculate CaCO₃ and MgCO₃. Sand content determined gravimetrically. Not suitable for cement mortars. Requires approx. 5 g of sample.</li><li><strong>Price:</strong> 1,275 CZK excl. VAT</li></ul><h5><strong>WI08104 – Semi-Quantitative Determination of Gypsum in Building Materials</strong></h5><ul><li>Based on solubility differences of gypsum and alkaline sulfates. Requires approx. 11 g of sample.</li><li><strong>Price:</strong> 1,100 CZK excl. VAT</li></ul><h5><strong>WI08105 – Determination of Bulk Density of Building Materials</strong></h5><ul><li>Performed using quartz sand displacement. Requires 30–50 cm³ of sample in pieces 2–4 cm.</li><li><strong>Price:</strong> 440 CZK excl. VAT</li></ul><h5><strong>WI08109 – Determination of Hygroscopic Moisture in Building Materials</strong></h5><ul><li>Gravimetric method after equilibrium at 100% RH and drying at 105 °C for 2 hours. Requires approx. 10 g of sample.</li><li><strong>Price:</strong> 440 CZK excl. VAT</li></ul><h5><strong>WI08114 – Determination of Water Absorption of Building Materials</strong></h5><ul><li>Gravimetric method from weight difference between dried and water-saturated sample. Bulk density determined simultaneously. Requires 30–50 cm³ of sample in pieces 2–4 cm.</li><li><strong>Price:</strong> 4,495 CZK excl. VAT</li></ul><blockquote><p class="cke-user_style-important"><strong>10% discount when submitting 3 or more samples at once.</strong></p></blockquote><blockquote><h3><strong>Services – Laboratory</strong></h3><p>The <strong>Watrex Analytical Laboratory</strong> will be happy to perform any of our standard analyses, custom analyses, or assist you with <strong>method development</strong>.</p><p>We specialize primarily in <strong>liquid chromatography techniques</strong> and are ready to meet a wide range of requirements—from <strong>method development and optimization</strong>, through <strong>validation and verification of external methods</strong>, to <strong>training and troubleshooting</strong>.</p><p>Our laboratory also <strong>manufactures and packs its own chromatographic columns and guard columns</strong> for basic HPLC modes (<strong>reversed phase, normal phase, ion chromatography, and ion exclusion chromatography</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637"></p></blockquote>

Identification of the substance – what is in your sample? (Bioanalytic)

We are able to identify metabolites and products of chemical reactions, contaminants of biological and chemical substances and preparations, and perform profiling of a series of samples to study the kinetics of transformations.

<h4><strong>Substance Identification - Looking for answers to what's in your sample? - we can help you.</strong></h4><p>Substance identification based on LC-MS/MS techniques can involve single compounds or mixtures of substances. In our analyses, we rely primarily on the knowledge and skills we have acquired after many years of work. For analysis, we use full laboratory facilities for sample preparation and high-resolution mass spectrometry (<a target="_blank" rel="noopener noreferrer" href="https://labexperts.com.pl/o-nas/">equipment</a>).</p><p>We use different work algorithms depending on the material we are dealing with and the analytical task to be solved. We use DDA (IDA) or DIA (SWATH) methods or targeted approaches (e.g. MRMhr) if we know what to expect. Thus, we are able to identify metabolites and products of chemical reactions, contaminants of biological and chemical substances and preparations, and perform profiling of a series of samples to study the kinetics of transformations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_2_0f425a648b.jpg" alt="Bioanalytic: Identification of the substance – what is in your sample" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_2_0f425a648b.jpg 245w," sizes="100vw" width="1881" height="1156"></p><h4><strong>COST OF SERVICE</strong></h4><p>We determine the cost of the service individually. The final cost is influenced by many factors related to the nature of the sample itself and the client's expectations. Thus, the price depends, among other things, on the complexity of the sample preparation procedure, the scope and number of analyses, etc.</p><p><strong>The service includes (depending on individual arrangements):</strong></p><h5><strong>Development of sample preparation procedure</strong></h5><ul><li>Depending on the matrix and test substances.</li></ul><h5><strong>Development of analytical methods</strong></h5><ul><li>Application of high-resolution LC-MS/MS analyses using DDA (IDA) or DIA (SWATH) experiments and software to support the development of targeted screening methods.</li></ul><h5><strong>Analysis of results includes:</strong></h5><ul><li>finding and identifying the substances of interest, interpreting MS/MS spectra and proposing a structural formula.</li><li>Comparative analysis of sample series, e.g. PCA,</li><li>profiling of analytes in sample series</li></ul><h5><strong>Reporting of results</strong></h5><ul><li>Compile results into easy-to-read reports.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_3_c1b8adc1d0.jpg" alt="Bioanalytic: Identification of the substance – what is in your sample" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_3_c1b8adc1d0.jpg 245w," sizes="100vw" width="1919" height="1208"></p>

Advanced PFAS Analytical Services (ALS)

Comprehensive PFAS analysis in water, soil, sludge, and AFFF sites using LC-MS/MS. Detect 60+ PFAS compounds, meet EU limits, and ensure compliance with evolving 2025 regulations.

<h4><strong>Advanced PFAS Analytical Services</strong></h4><h5><strong>Ensuring Compliance, Safety and Environmental Responsibility</strong></h5><p><strong>Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals widely used in industrial applications and consumer products. Their persistence in the environment and potential health risks have led to increasing regulatory scrutiny, particularly in drinking water and firefighting foam residues.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_Advanced_PFAS_Analytical_Services_c8d8b28b7c.jpg" alt="ALS: Advanced PFAS Analytical Services" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_Advanced_PFAS_Analytical_Services_c8d8b28b7c.jpg 245w," sizes="100vw" width="1604" height="502"></p><h4><strong>Our Expertise</strong></h4><p><strong>We offer state-of-the-art analytical services for the detection and quantification of PFAS in:</strong></p><ul><li>Drinking/ground/surface/waste water</li><li>Soil, sediment, sludge and biosolids</li><li>AFFF-contaminated sites and products</li></ul><h5><strong>Using LC-MS/MS, our laboratories provide:</strong></h5><ul><li>Ultra-trace level detection (ng range)</li><li>Analysis of over <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_01_europe_the_scope_of_pfas_analyses_in_waters_and_current_state_of_legislation_6ebd4f1b6f/enviromail_01_europe_the-scope-of-pfas-analyses-in-waters-and-current-state-of-legislation.pdf"><strong>60 individual PFAS compounds</strong></a></li><li>Non-targeted PFAS analysis like TOPA</li></ul><blockquote><h5><strong>Contact Us</strong></h5><p>Let us help you navigate the complex landscape of PFAS regulation and ensure your operations meet the highest standards of safety and compliance.</p><ul><li>+420 226 226 228</li><li><a href="mailto:customer.support@alsglobal.com">customer.support@alsglobal.com</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.alsglobal.eu/">alsglobal.eu</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_PFAS_421ef75bea.jpg" alt="ALS: PFAS Analytical Services" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_PFAS_421ef75bea.jpg 156w," sizes="100vw" width="919" height="919"></p></blockquote><h4><strong>Regulatory Context in Europe (2025)</strong></h4><p><strong>European legislation is rapidly evolving to address PFAS contamination:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://eur-lex.europa.eu/legal-content/EN/LSU/?uri=oj:JOL_2020_435_R_0001">The EU Drinking Water Directive (2020/2184) </a>mandates monitoring of PFAS, with a parametric value of 0.10 μg/L for the sum of 20 PFAS compounds</li><li><a target="_blank" rel="noopener noreferrer" href="https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=OJ:L:2006:396:TOC">Reach Regulation 1907/2006</a> and the key <a target="_blank" rel="noopener noreferrer" href="https://eur-lex.europa.eu/eli/reg/2021/1297/oj/eng">Amendment Regulation 2021/1297</a>, targeting the C9-C14 perfluorocarboxylic acids and related substances</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.consilium.europa.eu/en/press/press-releases/2025/04/10/soil-monitoring-law-council-reaches-deal-with-parliament/">The Soil Monitoring law</a> (provisional agreement april 2025) includes PFAS as part of the soil Health assessment</li><li><a target="_blank" rel="noopener noreferrer" href="https://environment.ec.europa.eu/topics/water/water-framework-directive_en">The Water Frame Directive </a>with EQS on surface and groundwater and considerations for sediments and biota</li></ul><h3><strong>List of PFAS analytes and report limits for determining PFAS substances in water</strong></h3><p>For <strong>the sum of PFAS, a limit of 0.1 μg/l</strong> has been set, which applies to 20 substances marked with an asterisk (*) in the text below.</p><h5><strong>Group: Perfluoroalkyl carboxylic acids</strong></h5><p><strong>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)</strong></p><ul><li><strong>Perfluorobutanoic acid</strong> / <strong>PFBA</strong>* / 0.01 / 0.002</li><li><strong>Perfluoro-3-methoxypropanoic acid</strong> / <strong>PFMPA</strong> / 0.025 / 0.001</li><li><strong>Perfluoropentanoic acid</strong> / <strong>PFPeA</strong>* / 0.01 / 0.0003</li><li><strong>Perfluoro-4-methoxybutanoic acid</strong> / <strong>PFMBA</strong> / 0.025 / 0.001</li><li><strong>Perfluorohexanoic acid</strong> / <strong>PFHxA</strong>* / 0.01 / 0.0003</li><li><strong>Tetrafluoro-2-(heptafluoropropoxy) propanoic acid</strong> / <strong>HFPO-DA</strong> / 0.02 / 0.001</li><li><strong>Perfluoroheptanoic acid</strong> / <strong>PFHpA</strong>* / 0.01 / 0.0003</li><li><strong>4,8-dioxa-3H-perfluorononanoic acid</strong> / <strong>DONA</strong> / 0.01 / 0.002</li><li><strong>7H-perfluoroheptanoic acid</strong> / <strong>HPFHpA</strong> / 0.01 / 0.001</li><li><strong>Perfluorooctanoic acid</strong> / <strong>PFOA</strong>* / 0.005 / 0.0003</li><li><strong>Perfluoro-3,7-dimethyloctanoic acid</strong> / <strong>P37DMOA</strong> / 0.01 / 0.001</li><li><strong>Perfluorononanoic acid</strong> / <strong>PFNA</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorodecanoic acid</strong> / <strong>PFDA</strong>* / 0.01 / 0.0003</li><li><strong>2H,2H,3H,3H-Perfluorooctanoic acid</strong> / <strong>H4PFUnDA</strong> / 0.02 / 0.0003</li><li><strong>Perfluorooctanoic acid</strong> / <strong>PFUnDA</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorododecanoic acid</strong> / <strong>PFDoDA</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorotridecanoic acid</strong> / <strong>PFTrDA</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorotetradecanoic acid</strong> / <strong>PFTeDA</strong> / 0.025 / 0.0003</li><li><strong>Perfluorohexadecanoic acid</strong> / <strong>PFHxDA</strong> / 0.05 / n.a.</li><li><strong>Perfluorooctadecanoic acid</strong> / <strong>PFOcDA</strong> / 0.05 / n.a.</li></ul><h5><strong>Group: Perfluoroalkylsulfonic acids</strong></h5><p><strong>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)</strong></p><ul><li><strong>Perfluoropropanesulfonic acid</strong> / <strong>PFPrS</strong> / 0.02 / 0.001</li><li><strong>Perfluoro(2-ethoxyethane)sulfonic acid</strong> / <strong>PFEESA</strong> / 0.1 / 0.001</li><li><strong>Perfluorobutanesulfonic acid</strong> / <strong>PFBS</strong>* / 0.01 / 0.0003</li><li><strong>Perfluoropentanesulfonic acid</strong> / <strong>PFPeS</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorohexanesulfonic acid</strong> / <strong>PFHxS</strong>* / 0.01 / 0.0003</li><li><strong>Perfluoroheptanesulfonic acid</strong> / <strong>PFHpS</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorooctane sulfonic acid</strong> / <strong>PFOS</strong>* / 0.005 / 0.0003</li><li><strong>n-Decafluoro-4-(pentafluoroethyl) cyclohexane sulfonic acid</strong> / <strong>PFECHS</strong> / 0.01 / 0.0003</li><li><strong>Perfluorononane sulfonic acid</strong> / <strong>PFNS</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorodecane sulfonic acid</strong> / <strong>PFDS</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorooctadecane sulfonic acid</strong> / <strong>PFUnDS</strong>* / 0.01 / 0.001</li><li><strong>Perfluorododecane sulfonic acid</strong> / <strong>PFDoDS</strong>* / 0.01 / 0.0003</li><li><strong>Perfluorotridecane sulfonic acid</strong> / <strong>PFTrDS</strong>* / 0.02 / 0.001</li></ul><h5><strong>Group: Fluorotelomeric sulfonates</strong></h5><p><strong>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)</strong></p><ul><li><strong>4:2 fluorotelomeric sulfonate</strong> / <strong>4:2 FTS</strong> / 0.01 / 0.0003</li><li><strong>6:2 fluorotelomeric sulfonate</strong> / <strong>6:2 FTS</strong> / 0.01 / 0.0003</li><li><strong>8:2 fluorotelomeric sulfonate</strong> / <strong>8:2 FTS</strong> / 0.01 / 0.0003</li><li><strong>10:2 fluorotelomeric sulfonate</strong> / <strong>10:2 FTS</strong> / 0.01 / n.a.</li></ul><h5><strong>Group: Perfluorinated sulfonamides</strong></h5><p><strong>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)</strong></p><ul><li><strong>N-methyl-perfluorooctanesulfonamide</strong> / <strong>MeFOSA</strong> / 0.05 / 0.002</li><li><strong>N-ethyl perfluorooctane sulfonamide</strong> / <strong>EtFOSA</strong> / 0.05 / 0.002</li><li><strong>N-methyl perfluorooctane sulfonamidoethanol</strong> / <strong>MeFOSE</strong> / 0.025 / 0.002</li><li><strong>N-ethyl perfluorooctane sulfonamidoethanol</strong> / <strong>EtFOSE</strong> / 0.025 / 0.002</li></ul><h5><strong>Group: Perfluorooctane sulfonamidoacetic acid derivatives</strong></h5><p><strong>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)</strong></p><ul><li><strong>Perfluorooctane sulfonamidoacetic acid</strong> / <strong>FOSAA</strong> / 0.01 / 0.001</li><li><strong>N-Methyl perfluorooctane sulfonamidoacetic acid</strong> / <strong>MeFOSAA</strong> / 0.01 / 0.001</li><li><strong>N-Ethyl perfluorooctane sulfonamidoacetic acid</strong> / <strong>EtFOSAA</strong> / 0.01 / 0.001</li></ul><h5><strong>Group: Fluorotelomeric carboxylic acids</strong></h5><p><strong>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)</strong></p><ul><li><strong>3-Perfluoropropyl propanoic acid (3:3)</strong> / <strong>3:3 FTCA</strong> / 0.1 / 0.0003</li><li><strong>n-2-Perfluorohexyl ethanoic acid (6:2)</strong> / <strong>6:2 FTCA</strong> / 0.1 / 0.001</li><li><strong>3-Perfluoropentyl propanoic acid (5:3)</strong> / <strong>5:3 FTCA</strong> / 0.02 / 0.001</li><li><strong>2H-Perfluoro-2-octenoic acid (6:2)</strong> / <strong>6:2 FTUCA</strong> / 0.02 / 0.001</li><li><strong>3-Perfluoroheptyl propanoic acid (7:3)</strong> / <strong>7:3 FTCA</strong> / 0.02 / 0.0003</li><li><strong>n-2-Perfluorooctyl ethanoic acid (8:2)</strong> / <strong>8:2 FTCA</strong> / 0.1 / 0.001</li><li><strong>2H-Perfluoro-2-decanoic acid (8:2)</strong> / <strong>8:2 FTUCA</strong> / 0.02 / 0.001</li></ul><h5><strong>Group: Chlorinated perfluoroalkyl sulfonic acids</strong></h5><p><strong>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)</strong></p><ul><li><strong>9-Chlorohexadecafluoro-3-oxanonane-1-sulfonic acid</strong> / <strong>9Cl-PF3ONS</strong> / 0.01 / 0.001</li><li><strong>11-Chloroeicosafluoro-3-oxaundecane-1-sulfonic acid</strong> / <strong>11Cl-PF3OUdS</strong> / 0.01 / 0.002</li></ul><p>*<i>Analytes included in the sum of 20 PFAS in drinking water according to DIRECTIVE (EU) 2020/2184 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2020 on the quality of water intended for human consumption.</i></p><h4><strong>Applications</strong></h4><ul><li>Site investigations and remediation planning</li><li>Compliance monitoring for water utilities</li><li>Environmental due diligence for industrial sites</li><li>AFFF legacy contamination assessments</li><li>Products compliance</li></ul><h4><strong>Why Choose Us?</strong></h4><ul><li>Accredited laboratories with experience in regulatory, diagnostic and scientific PFAS analyses</li><li>Rapid turnaround times and customizable reporting formats</li><li>Expert support for laboratories, environmental consultants, utilities, and industrial clients</li><li>Webinars by specialists in the field</li></ul><blockquote><h5><strong>Read more about PFAS analysis:</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_02_europe_sampling_recommendations_for_pfas_to_maximize_data_quality_26c1da00bb/enviromail_02_europe_sampling-recommendations-for-pfas-to-maximize-data-quality.pdf"><strong>EnviroMail™ 02/Europe: Sampling Recommendations for PFAS to Maximize Data Quality</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_10_europe_pfas_forever_chemicals_in_soil_a5b49ad7dd/enviromail_10_europe_pfas_forever-chemicals-in-soil.pdf"><strong>EnviroMail™ 10/Europe: PFAS: “Forever chemicals” in soil</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_13_europe_passive_sampling_for_the_monitoring_of_pfas_in_water_feb2024_227a69e2dc.pdf"><strong>EnviroMail™ 13/Europe: Passive sampling for the monitoring of PFAS in water</strong></a></li></ul></blockquote>

Products from category Industry and Chemistry Analyses - page 1

Related content

News from LabRulezLCMS Library - Week 33, 2026

Seeing is Believing – Detection Made Easy Part 1: Detector Overview

Graphene nanomaterial developed in Olomouc recognised among Europe’s most promising innovations