In the week of March 23, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Aromatic profiling using GCMS and HRGCMS</h5><ul><li>Tu, 24.3.2026 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6020">Registration</a></li></ul>Discover how high-resolution GC–MS and LC–MS reveal the complex aroma chemistry of blue fenugreek. Learn how advanced separation strategies improve detection of volatile and precursor compounds.<h5>2. Waters Corporation: Bioanalysis simplified – A case study with Basile Khara</h5><ul><li>Tu, 24.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5921">Registration</a></li></ul>How OligoWorks™ SPE Microplate Kit simplifies oligonucleotide sample preparation.<h5>3. Merck: Innovate and Accelerate: Leveraging 3Rs for Superior Cell Line Characterization</h5><ul><li>Tu, 24.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6021">Registration</a></li></ul>In this webinar, we review the regulatory landscape and explore an approach to developing 3Rs roadmaps.<h5>4. Phenomenex: Characterizing Antibody-Oligonucleotide Conjugates (AOCs) Under Native and Reversed-Phase Conditions</h5><ul><li>We, 25.3.2026 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5964">Registration</a></li></ul>This webinar will showcase complementary LC-MS methods developed to characterize AOCs composed of a trastuzumab biosimilar conjugated with siRNA or ASO.<h5>5. Thermo Fisher Scientific: Why HPLC-CAD is ideal for quality assurance of APIs and excipients</h5><ul><li>We, 25.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6023">Registration</a></li></ul>Discover how HPLC-CAD enhances impurity profiling of APIs and excipients, enabling sensitive, near-universal detection beyond UV limits for robust pharmaceutical quality control workflows.<h5>6. SCIEX: Comprehensive characterization of monoclonal antibodies using SCIEX HRMS platforms</h5><ul><li>We, 25.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5959">Registration</a></li></ul>Explore comprehensive monoclonal antibody characterization using SCIEX HRMS, featuring Zeno trap sensitivity, EAD fragmentation, and real-world biotherapeutic case studies.<h5>7. Waters Corporation: Navigating Regulatory Guidance for LNP and Liposomal Drug Characterization Using FFF-MALS</h5><ul><li>We, 25.3.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5848">Registration</a></li></ul>Learn how FFF-MALS enables comprehensive characterization of lipid nanoparticles and liposomes, supporting regulatory-relevant CQAs such as size, morphology, and encapsulation efficiency.<h5>8. Metrohm: From Out-of-Spec Results to Audit-Ready: Controlling Titration in GxP Labs</h5><ul><li>We, 25.3.2026 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6022">Registration</a></li></ul>Learn how to resolve out-of-spec titration results with practical KF and potentiometric troubleshooting strategies, and discover how compliant software controls ensure audit-ready workflows.<h5>9. Thermo Fisher Scientific: Chromeleon Admin Console II: System management and automation</h5><ul><li>Th, 26.3.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6029">Registration</a></li></ul>In this practical session, we’ll dive into more Administration Console capabilities that help you manage and standardize your setup at scale.<h5>10. Waters Corporation: Master the challenging EQS values for endocrine active compounds</h5><ul><li>Th, 26.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5925">Registration</a></li></ul>Learn how a sensitive LC-MS/MS supports the detection of estrogens in different water types.<h5>11. Evosep Biosystems: Scalable Workflows for standardized proteomics</h5><ul><li>Th, 26.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5993">Registration</a></li></ul>Join us to learn how scalable proteomics workflows are moving from promise to practice.<h5>12. Waters Corporation: Rapid Analysis of GLP-1 Analogs Using Pre-Column Derivatization</h5><ul><li>Th, 26.3.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5922">Registration</a></li></ul>Discover a rapid, microwave-assisted UPLC amino acid analysis workflow for accurate GLP-1 analog characterization using AccQ·Tag Ultra chemistry and Empower CDS.<h5>13. Mettler-Toledo: Online HPLC Analysis with DirectInject-LC</h5><ul><li>Th, 26.3.2026 18:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5999">Registration</a></li></ul>Discover how DirectInject-LC transforms HPLC into an online PAT tool. Learn how to run experiments and gain near real-time reaction analysis insights.

Webinars LabRulezLCMS Week 13/2026

This study evaluates ion chromatography with electrical conductivity and UV absorbance detection for quantifying chloronitramide, a recently identified chloramine decomposition product, in tap water. Method performance showed strong agreement with HILIC–UHRMS results, enabling reliable detection across diverse water matrices.Chloronitramide was detected in both chloraminated and free chlorine systems, marking its first reported occurrence in the latter. The developed IC methods support large-scale monitoring of chloronitramide in drinking water, with UV detection providing reduced measurement bias and improved analytical reliability.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.estlett.5c01218">Chloronitramide Anion Quantitation in Tap Waters by Ion Chromatography with Electrical Conductivity and Ultraviolet Absorbance Detection</a></h4>Jason A. Thornhill, Juliana R. Laszakovits, Barrett E. Johnson, Justin R. Chimka, and Julian L. Fairey*Environ. Sci. Technol. Lett. 2026, 13, 2, 275–280<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.estlett.5c01218">https://doi.org/10.1021/acs.estlett.5c01218</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.<div>After ∼45 years since it was first detected in chloraminated water <a href="javascript:void(0);">(1)</a> and more than 30 years since its prior characterization efforts, <a href="javascript:void(0);">(2−5)</a> chloronitramide anion (Cl–N–NO2–) was identified as a decomposition product of inorganic chloramines. <a href="javascript:void(0);">(6)</a> In a limited survey of chloraminated tap waters in the United States, Cl–N–NO2– was found in all samples tested (n = 40) at a median concentration of 23 μg L–1 and first and third quartiles of 1.3 and 92 μg L–1, respectively. Although its toxicity is currently unknown, Cl–N–NO2– forms at levels comparable to some regulated disinfection byproducts (DBPs) but lower than others. For example, the Environmental Protection Agency (EPA) maximum contaminant levels (MCLs) for the mass-based sums of four trihalomethanes is 80 μg L–1 and five haloacetic acids is 60 μg L–1; <a href="javascript:void(0);">(7)</a> however, the chlorite MCL is over 1 order of magnitude greater, at 1 mg L–1. The Cl–N–NO2– formation pathway contrasts that of most other DBPs, which are formed by reactions between a disinfectant and source water precursors, such as natural organic matter (NOM) and/or bromide. <a href="javascript:void(0);">(8,9)</a> Cl–N–NO2– is formed by monochloramine (NH2Cl) or dichloramine (NHCl2) reacting with nitronium cation (NO2+), <a href="javascript:void(0);">(6)</a> a reactive nitrogen species formed during chloramine decomposition. <a href="javascript:void(0);">(10,11)</a> In this regard, Cl–N–NO2– is an intrinsic DBP, <a href="javascript:void(0);">(12)</a> like chlorate and perchlorate in hypochlorite feedstocks. <a href="javascript:void(0);">(13−16)</a> As chloramines are inherently unstable and autodecompose under typical conditions in drinking water systems, <a href="javascript:void(0);">(17−19)</a> Cl–N–NO2– is likely present in all waters where chloramines are used. This includes systems where chloramines are formed intentionally and free chlorine systems containing source water ammonia. <a href="javascript:void(0);">(20)</a> To facilitate Cl–N–NO2– occurrence studies and better understand its formation in tap water, analytical methods are needed for Cl–N–NO2– quantitation that leverage common instrumentation in drinking water laboratories.The discovery of Cl–N–NO2– was supported by its quantitation in chloraminated tap waters by hydrophilic interaction liquid chromatography–ultrahigh-resolution mass spectrometry (HILIC–UHRMS). <a href="javascript:void(0);">(6)</a> This method has a limit of detection (LOD) of 0.17 μg L–1 and a limit of quantitation (LOQ) of 0.58 μg L–1. However, the instrumentation required for HILIC–UHRMS (i.e., orbitrap mass spectrometers) is not widely accessible due to its high capital cost and operation and maintenance requirements, limiting collection of Cl–N–NO2– occurrence data. Cl–N–NO2– reference materials were previously isolated from mixtures containing common anions (e.g., chloride, nitrite, nitrate, sulfate, phosphate) at concentrations up to ∼100 mM using ion chromatography (IC) with electrical conductivity (EC) and ultraviolet absorbance (UV) detectors. <a href="javascript:void(0);">(6)</a> Given Cl–N–NO2– is an anion and has a molar absorptivity (ε) peak maxima at 243 nm of ε243 = 5,310 M–1 cm–1, <a href="javascript:void(0);">(6)</a> Cl–N–NO2– quantitation may be possible by IC-EC and/or IC-UV243, but the applicability of these methods at μg L–1 levels is unknown. IC methods could be a cost-effective alternative to MS-based methods and adopted at drinking water utilities and commercial water analysis laboratories, enabling widescale Cl–N–NO2– occurrence studies. The objective of this study is to assess IC-EC and IC-UV243 for Cl–N–NO2– quantitation in tap waters at μg L–1 levels. Cl–N–NO2– quantitation by IC-EC and IC-UV243 was compared to HILIC–UHRMS across an unprecedented range of Cl–N–NO2– concentrations in tap waters from U.S. residential homes.<h4>2. Materials and Methods</h4><h5>2.1. Ion Chromatography System</h5>A Metrohm 850 Professional IC equipped with an autosampler, suppressor, two electrical conductivity detectors, and an 887 Professional UV/vis detector was used to isolate Cl–N–NO2– standard reference materials and quantify Cl–N–NO2– in tap waters. Two Metrosep A Supp 7 separation columns were used, each 250 mm in length with a 4.0 mm diameter, one for Cl–N–NO2– isolation that had been used extensively (&gt;10,000 injections) and regenerated to maintain adequate anion separation and the second newly acquired for Cl–N–NO2– quantitation in drinking water matrices. Both IC columns consist of a PEEK housing packed with a poly(vinyl alcohol) carrier material with quaternary ammonium groups, 5 μm particle size, 15 MPa maximum pressure, 1.0 mL min–1 maximum flow rate, pH range 3–12, and temperature range of 20–60 °C. Na2CO3 eluent concentrate (Metrohm) was diluted 100× to 3.6 mM for Cl–N–NO2– isolation and 25× to 14.4 mM for Cl–N–NO2– quantitation.<h4>3. Results and Discussion</h4><h5>3.4. Tap Water Comparison of IC and HILIC–UHRMS</h5><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.estlett.5c01218#fig2">Figure 2</a> shows Cl–N–NO2– concentrations in the 12 tap waters measured by IC-EC and IC-UV243 peak area compared to the HILIC–UHRMS method developed in prior work. <a href="javascript:void(0);">(6)</a> <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.estlett.5c01218/suppl_file/ez5c01218_si_001.pdf">Figure s30</a> shows these data for peak height.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Environ_Sci_Technol_Lett_2026_13_2_275_280_Figure_2_Ion_chromatography_electrical_conductivity_IC_EC_Panels_A_and_B_and_ultraviolet_absorbance_at_243_nm_18517febbb.jpg" alt="Environ. Sci. Technol. Lett. 2026, 13, 2, 275–280: Figure 2. Ion chromatography-electrical conductivity (IC-EC, Panels A and B) and -ultraviolet absorbance at 243 nm (IC-UV243, Panels C and D) comparison testing with HILIC–UHRMS for Cl–N–NO2– quantitation in 12 waters which included eight chloraminated tap waters (TX-1, PA, TX-2, SC, CA, TX-3, OK, and MN), three chlorinated tap waters (AR, GA-1, and GA-2), and one synthetic groundwater (GW) with no added disinfectant. (A) IC-EC measured by peak area vs Cl–N–NO2– determined by HILIC–UHRMS, (B) IC-EC residuals by peak area, (C) IC-UV243 measured by peak area vs Cl–N–NO2– determined by HILIC–UHRMS, and (D) IC-UV243 residuals by peak area. The solid black line in Panels A and C is the 1:1 line and shown with the correlation coefficient, R2. The average residual ( 𝑟𝑖⎯⎯⎯ ; n = 12) in μg L–1 is shown in Panels B and D as a measure of the linear regression model bias and accuracy with values closer to zero indicating lesser overall bias." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Environ_Sci_Technol_Lett_2026_13_2_275_280_Figure_2_Ion_chromatography_electrical_conductivity_IC_EC_Panels_A_and_B_and_ultraviolet_absorbance_at_243_nm_18517febbb.jpg 214w," sizes="100vw" width="1750" height="1279">Cl–N–NO2– quantified using the IC methods tracked the 1:1 line across the range of Cl–N–NO2– concentrations in the tap waters from not detected to 315 μg L–1, indicating they were strongly correlated with the HILIC–UHRMS measurements. For IC-EC, the R2 (n = 12) was 0.991 (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.estlett.5c01218#fig2">Figure 2</a>A) and the average residual (𝑟𝑖⎯⎯⎯) was +3.2 μg L–1, indicating an overall positive bias. For IC-UV243, the R2 (n = 12) was 0.997 and the&nbsp;𝑟𝑖⎯⎯⎯ was 0.0 μg L–1, indicating no overall bias. Therefore, the accuracy and precision of Cl–N–NO2– quantitation by IC-UV243 exceeded that of IC-EC for the tap waters tested. This is the first report, to the best of our knowledge, of Cl–N–NO2– presence in chlorinated tap waters. Although the Cl–N–NO2– concentrations are lower compared to chloraminated tap waters, this finding suggests that Cl–N–NO2– exposure is more widespread and additional formation pathways such as breakpoint chlorination could be relevant, as previously speculated. <a href="javascript:void(0);">(6)</a> The Cl–N–NO2– concentration maximum observed in the chloraminated tap waters (315 μg L–1) is greater by a factor of about three compared to that in prior work, <a href="javascript:void(0);">(6)</a> illustrating a pressing need for additional occurrence studies to capture its full range in water systems.We demonstrated that IC-EC and IC-UV243 can be used to accurately quantify Cl–N–NO2– in tap waters with minor modifications to the IC system (i.e., 5 mL injection loop and 14.4 mM Na2CO3 eluent) using standards formulated in 1 mM borate buffer at pH 9. While the lowest LOD (5.8 μg L–1) and LOQ (8.2 μg L–1) are greater than those for HILIC-UHRMS (0.17 and 0.58 μg L–1, respectively), the IC methods are accurate within an environmentally relevant range, with Cl–N–NO2– at levels up to about 315 μg L–1. Spike recovery experiments indicate matrix effects were negligible for Cl–N–NO2– quantitation by IC-EC and IC-UV243 for concentrations &lt;50 μg L–1 (i.e., P&lt;50&nbsp;μg&nbsp;L–1 &gt; 0.05). IC-based quantitation methods were strongly correlated with HILIC–UHRMS (R2 ≥ 0.991) and unbiased for quantitation by IC-UV243 peak area. Cl–N–NO2– may continue to form in tap waters containing a chloramine residual, particularly at pH ≲ 8 where chloramines decompose more readily. <a href="javascript:void(0);">(29)</a> A quenching agent/procedure has not yet been identified for chloramines that does not impact Cl–N–NO2–. Thus, the time between sample collection and analysis should be minimized (&lt;1 day, if possible) to get the most accurate assessment of Cl–N–NO2– occurrence until if/when a suitable sample preservation procedure is developed. Nevertheless, the IC methods developed and validated here can be adopted by water utilities and testing laboratories for widespread Cl–N–NO2– monitoring campaigns.</div>

Chloronitramide Anion Quantitation in Tap Waters by Ion Chromatography with Electrical Conductivity and Ultraviolet Absorbance Detection

Visit the LabRulez booth at <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871">analytica 2026</a> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"><h3>Would you like to learn how the LabRulez portals work?</h3>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/">LabRulezLCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/">LabRulezGCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/">LabRulezICPMS</a><ul><li>A unique online solution for your marketing</li><li>A targeted audience from the analytical chemistry community</li><li>Modern technologies and a unique concept</li><li>Design optimized for most smart devices – PC, mobile, and tablet</li><li>Advanced statistical tools fully available to users</li></ul><h3>Services Offered</h3><h4>News + Company Updates</h4><ul><li>Publish news related to your instrumentation, applications, services, events, job openings, and more</li><li>News is shared both on our portals and across our social media channels</li></ul><h4>Library – All Documents in One Place</h4><ul><li>Applications, posters, presentations, technical articles, brochures, specifications</li><li>Fast and advanced search capabilities</li><li>Over 32,000 documents currently available in our database</li></ul><h4>Webinars</h4><ul><li>Upcoming and on-demand webinars from the field of analytical chemistry</li><li>More than 5,500 webinars covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4>Careers</h4><ul><li>Targeted job listings in analytical chemistry</li><li>Clear filtering by specialization or location</li><li>Increased visibility for job postings</li></ul><h4>Companies</h4><ul><li>Company profile with key information and contacts</li><li>Integration of all your activities on our portal: News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li>Connection to your Products listed on LabRulez portals</li></ul><h4>Products and Services</h4><ul><li>Comprehensive overview of instrumental techniques and services</li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4>Marketplace</h4><ul><li>Buying and selling pre-owned analytical equipment</li><li>We purchase analytical instrumentation of all brands and ages</li><li>Sell your equipment through LabRulez</li><li>Request and purchase complete systems, modules, or spare parts with warranty and service</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"><h3>What Will Be on Display at Our Booth?</h3>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar">LabRulezLCMS Marketplace</a></h4>Spare parts for LC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378">Vacuum turbo pumps for LC/MS</a></li></ul>Spare parts for HPLC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397">Degassers for HPLC/UHPLC</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve">Automatic valves for HPLC</a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377">HPLC lamps</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48">HPLC columns</a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar">LabRulezGCMS Marketplace</a></h4>Spare parts for GC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo">Turbo pumps for GC/MS</a></li></ul>Spare parts for GC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC">EPC modules</a></li></ul>Sample injection<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432">Autosampler 7693A for GC</a></li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7">GC columns </a>and selected accessories</li></ul>

LabRulez at analytica 2026

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Watrex SCS 205 GPC Sample cleanup system

The Watrex Streamline SCS 205 Sample Clean-up System is designed for GPC sample pretreatment.

Sample clean-up is an essential method for many routine chromatography applications. One of the most common cases is analysis of polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and pesticides in complex mixtures.The initial step is an isolation of hydrophobic (lipophilic) components from the rest of the sample mixture by gel-permeation chromatography (GPC).In such configuration, triglycerides (700-900Da) can be isolated from low molecular (200-300Da) PAHs, PCBs or pesticides using GPC steric exclusion. SCS 205 is a dedicated system for GPC sample pretreatment. SCS 205 includes an isocratic pump double piston pump, manual injector with preparative sample loop, PAH/PCB preparative column (200mg sample loading capacity), fraction collector and start-up kit. .The entire system is controlled from a TFT touch display through intuitive screens.After injection and GPC separation, the purified sample (PAHs, PCBs etc.) is captured by an automated fraction collection usinga3-way motorized switching valve. The timing of the collection is predetermined from the elution profile of the pollutants.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_column_7dce4f25e0.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - column"><h3>FEATURES</h3><ul><li>High performance pollutant izolation from complex matrices</li><li>Eluent flexibility</li><li>Easy programmable</li><li>Easy installation &amp; Simple operation</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_schema_ad45276ad0.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - schema"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_graph_10ce455cc3.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - graph"><h3>TECHNICAL SPECIFICATION</h3><ul><li>Sampling System: manual valve</li><li>Sample volume: 2 mL loop</li><li>Fraction collection: 50mL flask</li><li>Collection time programming: alternating valve switching to waste/collect/waste</li><li>Display: 4-character</li></ul><h3>Ordering information:</h3><h5>PN/Component:</h5><ul><li>SCS205-001 SCS 205 Sample Clean-up System (Price 8 627 € ex VAT)</li><li>WI02077 WATREX 250x16 mm PAH Prep column, 10 um</li><li>DGD.3008 WATREX 300x8 mm DeltaGel Mixed-D column, 5 um</li><li>DGB.25020 WATREX 250x20 mm DeltaGel Mixed-B column, 5 um</li></ul>You can also visit this product on the <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/dedicated-instruments/scs-205-sample-clean-up-system/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty">Watrex website</a>.

Identification of the substance – what is in your sample? (Bioanalytic)

We are able to identify metabolites and products of chemical reactions, contaminants of biological and chemical substances and preparations, and perform profiling of a series of samples to study the kinetics of transformations.

<h4>Substance Identification - Looking for answers to what's in your sample? - we can help you.</h4>Substance identification based on LC-MS/MS techniques can involve single compounds or mixtures of substances. In our analyses, we rely primarily on the knowledge and skills we have acquired after many years of work. For analysis, we use full laboratory facilities for sample preparation and high-resolution mass spectrometry (<a target="_blank" rel="noopener noreferrer" href="https://labexperts.com.pl/o-nas/">equipment</a>).We use different work algorithms depending on the material we are dealing with and the analytical task to be solved. We use DDA (IDA) or DIA (SWATH) methods or targeted approaches (e.g. MRMhr) if we know what to expect. Thus, we are able to identify metabolites and products of chemical reactions, contaminants of biological and chemical substances and preparations, and perform profiling of a series of samples to study the kinetics of transformations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_2_0f425a648b.jpg" alt="Bioanalytic: Identification of the substance – what is in your sample" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_2_0f425a648b.jpg 245w," sizes="100vw" width="1881" height="1156"><h4>COST OF SERVICE</h4>We determine the cost of the service individually. The final cost is influenced by many factors related to the nature of the sample itself and the client's expectations. Thus, the price depends, among other things, on the complexity of the sample preparation procedure, the scope and number of analyses, etc.The service includes (depending on individual arrangements):<h5>Development of sample preparation procedure</h5><ul><li>Depending on the matrix and test substances.</li></ul><h5>Development of analytical methods</h5><ul><li>Application of high-resolution LC-MS/MS analyses using DDA (IDA) or DIA (SWATH) experiments and software to support the development of targeted screening methods.</li></ul><h5>Analysis of results includes:</h5><ul><li>finding and identifying the substances of interest, interpreting MS/MS spectra and proposing a structural formula.</li><li>Comparative analysis of sample series, e.g. PCA,</li><li>profiling of analytes in sample series</li></ul><h5>Reporting of results</h5><ul><li>Compile results into easy-to-read reports.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_3_c1b8adc1d0.jpg" alt="Bioanalytic: Identification of the substance – what is in your sample" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_3_c1b8adc1d0.jpg 245w," sizes="100vw" width="1919" height="1208">

Characteristics of monoclonal antibodies (Bioanalytic)

At LabExperts, proteomic analyses are performed on a ZenoTOF 7600 high-resolution LC-MS/MS system (SCIEX). For MS/MS analyses, we use Collision induced dissociation (CID) and Electron-Activated Dissociation (EAD) fragmentation.

Antibodies are molecules made up of 4 polypeptide chains: two heavy (H - high-chain) linked to each other by a specific type of chemical bond - a disulfide bridge, and two light (L - light-chain) linked by an identical bond to the heavy chains. Monoclonal antibodies (mABs) are used in various forms - as free molecules, in the form of a drug-antibody combination, and in the form of an immunoconjugate, a drug-antibody-biopolymer combination.Their main use is in highly specific targeted therapy for cancer, cardiovascular, autoimmune and nervous system diseases. They are also used in the treatment of osteoporosis, Alzheimer's disease or transplantation. The range of applications of monoclonal antibodies is systematically expanded. The introduction of a new antibody to the market requires complex product characterization, which involves numerous proteomic analyses, which are performed by LC-MS/MS techniques, among others.<h4>LC-MS/MS</h4>The characterization of monoclonal antibodies involves many aspects, including, but not limited to, a suite of analyses related to confirmation of the structure, chain sequence and degree of modification of the antibody. Post-translational modifications (PTMs) are chemical changes that occur after the translation process. These changes generally result in an increase in the immunogenicity of the drug. For this reason, it is essential to monitor modifications as critical quality attributes (CQAs) during both the production and storage of the drug. To ensure monitoring of CQA points, the primary structure of the protein is characterized based on peptide mapping (peptide mapping) analysis. The protein under study is subjected to proteolytic digestion using enzymes such as trypsin, chymotrypsin, Lys-C, Glu-C. As a result of various proteolytic enzymes, a wide range of peptides is obtained. Ultimately, coverage of the entire sequence of the protein under study is obtained.<figure class="image"><img style="aspect-ratio:1536/947;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Characteristics_of_monoclonal_antibodies_3_d94fa1623b.jpg" alt="Bioanalytic: Characteristics of monoclonal antibodies." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Characteristics_of_monoclonal_antibodies_3_d94fa1623b.jpg 245w," sizes="100vw" width="1536" height="947"></figure>At LabExperts, proteomic analyses are performed on a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?manufacturerItems=52&amp;search=ZenoTOF+7600">ZenoTOF 7600</a> high-resolution LC-MS/MS system (SCIEX). For MS/MS analyses, we use Collision induced dissociation (CID) and Electron-Activated Dissociation (EAD) fragmentation. This provides us with data for unambiguous identification of protein-building amino acids. We process the results using Sciex OS, Skyline and Spectronaut software.<blockquote>We perform:<ul><li>Whole protein analyses - Intact - to determine the exact mass and confirm the theoretical mass;</li><li>N-glycosylation profile determination (based on MS spectrum reconstruction):<ul><li>Glycosylated form;</li><li>Deglycosylated;</li><li>Glycosylated with reduced disulfide bridges;</li><li>Deglycosylated with reduced disulfide bridges.</li></ul></li><li>Peptide maps:<ul><li>Protein digestion with various proteases so that sequence coverage is close to 100%<ul><li>Analysis of PTMs:</li><li>Location of modifications</li></ul></li><li>[%] of modifications compared to the unmodified sequence</li></ul></li><li>TiPOS testing - (technical proof of similarity) - technical confirmation of the similarity of the protein synthesized by the customer (from several LOTs) with the target protein (provided as a template).</li></ul>In order to maintain the highest possible analytical standards, we perform monoclonal antibody analyses under the regime of an internally developed and implemented laboratory quality system based on GLP principles.See also our other proteomics services: <a target="_blank" rel="noopener noreferrer" href="https://labexperts.com.pl/service/identyfikacja-bialek/">Protein identification</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1294">Protein quantitative analysis</a></blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Characteristics_of_monoclonal_antibodies_2_cb93143fe6.jpg" alt="Bioanalytic: Bioanalytic Characteristics of monoclonal antibodies." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Characteristics_of_monoclonal_antibodies_2_cb93143fe6.jpg 245w," sizes="100vw" width="1536" height="908"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Characteristics_of_monoclonal_antibodies_1_0e8ab7cdfa.jpg" alt="Bioanalytic: Bioanalytic Characteristics of monoclonal antibodies." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Characteristics_of_monoclonal_antibodies_1_0e8ab7cdfa.jpg 245w," sizes="100vw" width="1536" height="858">

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