<div>Mulching films used in agriculture gradually break down and can become a significant source of microplastics in soils. A new study shows that these particles affect not only soil structure but also microbial life and nitrogen cycling.“We wanted to understand how microplastics from both conventional and biodegradable mulching films influence soil properties, microbial diversity and functions in real conditions,” explains Klára Šmídová, the study’s co-author . “That’s why we added realistic amounts of microplastics to soils in experimental plots in Finland, Germany, and Spain, monitored them over two growing seasons, and compared them with the control plots.”The results revealed that microplastics alter soil characteristics and microbial communities, although not always in the same way. “ However, a consistent finding was the decline in microbial activity associated with key processes, including nitrogen cycling, with negative effects increasing at higher microplastic concentrations and becoming more pronounced in the second year,” Šmídová adds. Because the microplastic levels used in the study reflect amounts already found in European soils, the findings highlight real risks to soil health. “We also found that the effects were stronger in southern than in northern Europe, likely due to differences in climate and soil conditions. This means that protecting soils from plastic pollution will require region-specific risk assessments,” she says.Over 60% of European soils are estimated to be unhealthy, with ongoing degradation driven by unsustainable land use, contamination, climate change, and extreme weather events. In response, the EU Parliament adopted the Soil Monitoring Law in October 2025, aiming to achieve healthy soils across Europe by 2050. “The law highlights the role of soil health in food security, water quality, and climate objectives, and establishes consistent soil monitoring across Member States. It includes measures to support farmers and foresters, while also creating a public list of potentially contaminated sites and an indicative watch list of emerging soil contaminants,” explains Klára Šmídová.The project brought together 19 research groups across Europe. “After each season, hundreds of samples were colle cted and sent to partners for analysis. This paper focuses on soil properties, microbial diversity, and greenhouse gas emissions. Two more manuscripts—on plastic additives and microplastic fate, and on soil invertebrates—are in preparation. Together, they will give us a complete picture of how agricultural microplastics affect soil ecosystems,” concludes Klára Šmídová.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg" alt="RECETOX: New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg 171w," sizes="100vw" width="738" height="674"><blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0269749125015866?via%3Dihub#sec2">Conventional and biodegradable agricultural microplastics: effects on soil properties and microbial functions across a European pedoclimatic gradient</a></h4>Šmídová K., Soinne H., Kim S. W., Tirronniemi J., Meffe R., Redondo-Hasselerharm P. E., Braun M., Rillig M. C., Fritze H., Adamczyk B., Nikama J., Kaseva J., Saartama V., Amelung W., Hurley R., Hofman J., Nizzetto L., Selonen S., Velmala S.Environ. Pollut. 386 (2025) 127212<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.envpol.2025.127212">10.1016/j.envpol.2025.127212</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4><div>Agricultural plastics like mulching films may become a major source of microplastic (MP) soil contamination during their degradation and fragmentation. This study investigates the effects of agricultural MPs from conventional (linear low-density polyethylene, PE) and biodegradable (starch-blended polybutylene adipate co-terephthalate, PBAT-BD) mulching films on soil physicochemical properties, aggregation, microbial diversity and functions, litter decomposition, and greenhouse gases emissions (GHG). For this purpose, MPs were mixed into soils at realistic MP concentrations of 0.005&nbsp;% and 0.05&nbsp;% (w/w) in 2022 on experimental plots in three EU countries representing different pedoclimatic conditions (Finland, Germany and Spain), followed by monitoring of the above-mentioned variables in the subsequent growing seasons 2022 and 2023. We found several significant MP-induced effects for soil properties, aggregation, microbial diversity, litter decomposition, and GHG, but the effect endpoints were less pronounced or varied considerably. Contrarily, microbial activity, contributing to soil functions such as nitrogen cycling, was consistently reduced by both conventional and biodegradable MPs. The reductions were more pronounced after the second season and for the higher MP treatment. As the higher MP concentration (i.e., 0.05&nbsp;% w/w) is environmentally relevant in Europe, our findings emphasize the potential effects of environmentally relevant MP concentrations on soil health. Furthermore, the effects increased from north to south, probably modulated by varying pedoclimatic conditions, inducing reflection of a need for regionally tailored risk</div></div>

New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions

<h3>Charged for Action: The Hidden Secrets of AEX Oligonucleotide Analysis</h3>Oligonucleotides—short, well-defined fragments of DNA or RNA—have become indispensable tools in modern life sciences. They underpin cutting-edge applications in molecular diagnostics, gene therapy, and pharmaceutical development. Before oligonucleotides can be confidently used in research or clinical settings, however, their quality must be rigorously assessed. Purity, sequence integrity, length distribution, and chemical modifications all play a decisive role in their performance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg" alt="KNAUER: Oligos Made Easy - Part 2: AEX" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg 245w," sizes="100vw" width="1534" height="711">Among the analytical techniques available today, anion exchange chromatography (AEX) stands out as a robust and highly informative method for characterizing oligonucleotides. By exploiting their intrinsic negative charge, AEX provides detailed insight into product composition and impurity profiles that are difficult to obtain by other approaches.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6808">Part 1 of the Oligos series: A Practical Guide to Oligonucleotide Production – From Concept to Final Product</a></blockquote><h4>How Scientists Read Oligonucleotides Using Charge</h4>At the core of AEX lies a simple but powerful principle: oligonucleotides carry a negatively charged phosphate backbone. This charge increases in a predictable way with strand length and, to a lesser extent, sequence composition. Anion exchange chromatography uses this property to separate oligonucleotides based on differences in charge strength and interaction with a positively charged stationary phase.As a result, AEX has become one of the most widely used analytical tools for evaluating oligonucleotide quality. It allows scientists to distinguish full-length products from truncated species, degradation products, or closely related variants—often with single-nucleotide resolution.<h4>Why Ion Exchange Works: Binding, Retention, and Release</h4>Ion exchange chromatography (IEX) relies on electrostatic interactions between analytes and a charged stationary phase. In the case of oligonucleotides, anion exchange is used, where negatively charged molecules interact with positively charged functional groups on the resin—most commonly quaternary amines.The system consists of two main components:<ul><li>Stationary phase: A positively charged resin that binds anionic analytes.</li><li>Mobile phase: An aqueous buffer system, typically combined with a salt gradient, that controls both pH and elution strength.</li></ul>Retention in AEX is governed primarily by charge. Molecules with weaker overall charge interact less strongly with the stationary phase and elute earlier, while more highly charged oligonucleotides bind more tightly and require stronger elution conditions.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 1 IEX overview including elution order dependency on analyte charge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg 245w," sizes="100vw" width="1583" height="654"><h4>The Five-Step Workflow of Ion Exchange Chromatography</h4>AEX separations generally follow a well-established sequence of steps:<ol><li>Column equilibration The column is conditioned with the starting buffer until the baseline and pH are stable. This ensures that all charged sites on the resin are ready for interaction.</li><li>Sample loading Samples, prepared in the starting buffer, are introduced under conditions that promote binding of the target oligonucleotides while minimizing retention of unwanted impurities.</li><li>Washing The column is washed with the starting buffer to remove uncharged or weakly interacting components. The baseline stabilizes as these species are flushed away.</li><li>Elution Bound oligonucleotides are released using a salt or pH gradient. Increasing ionic strength introduces competing ions that displace the analytes from the resin. Weakly bound species elute first; strongly charged oligonucleotides elute later.</li><li>Regeneration and re-equilibration A high-salt buffer removes any remaining bound material. The column is then returned to starting conditions in preparation for the next analysis.</li></ol><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 2 Five steps of IEX procedure (in blue), outlined using an example chromatogram (in red)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg 245w," sizes="100vw" width="1583" height="674"><h4>Why AEX Is Especially Effective for Oligonucleotides</h4>The repeating phosphate backbone of oligonucleotides gives rise to a strong and uniform anionic character across a wide pH range (typically pH 7–9). This makes oligonucleotides exceptionally well suited for anion exchange separations.Key factors influencing AEX behavior include:<ul><li>Charge density: Longer oligonucleotides carry more negative charges and therefore exhibit stronger retention.</li><li>Resin chemistry: Strong and weak anion exchangers differ in functional groups and pH stability, influencing selectivity and robustness.</li><li>Buffer composition: The choice of buffering ions and salt gradients directly affects elution strength and resolution.</li></ul>Salt gradients—commonly based on chloride ions—compete with the oligonucleotide backbone for binding sites on the resin. By carefully tuning gradient slope and composition, analysts can achieve highly reproducible and finely resolved separations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 3 Ionic interactions and pH influence on Anion Exchange Chromatography (AEX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg 245w," sizes="100vw" width="1547" height="593"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 4 AEX buffer selection and gradient strategy (chromatogram with red buffer gradient curve)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg 245w," sizes="100vw" width="1600" height="327"><h4>AEX as the Gold Standard for Oligonucleotide Separation</h4>Anion exchange chromatography has become the method of choice for both analytical and preparative oligonucleotide workflows. Its advantages include:<ul><li>High resolving power: Closely related impurities, including n–1 or n–2 species, can often be separated and quantified.</li><li>Predictable retention behavior: In many cases, retention time correlates linearly with oligonucleotide length, simplifying identification.</li><li>Compatibility with modified oligonucleotides: Even chemically modified sequences retain their anionic nature, allowing AEX to resolve both products and related impurities.</li><li>Excellent control via gradient elution: Salt gradients provide precise tuning of selectivity and resolution.</li></ul>Typically, shorter or degraded oligonucleotides elute at lower ionic strength, while full-length products with higher charge density appear later in the chromatogram.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 5 AEX Advantages and Challenges." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg 245w," sizes="100vw" width="1535" height="707"><h4>Final Perspective: Mastering AEX with Confidence</h4>Anion exchange chromatography may appear complex at first, but with thoughtful optimization of pH, buffer composition, and gradient conditions, it becomes a highly precise and reliable tool for oligonucleotide analysis. When properly applied, AEX delivers sharp peaks, excellent resolution, and robust performance—even for challenging sequences and modifications.For laboratories developing or refining oligonucleotide workflows, AEX offers both analytical depth and operational confidence.<blockquote>If you would like to discuss AEX method development or optimization for oligonucleotides, feel free to contact us at sales@knauer.net. More insights into practical oligonucleotide analysis will follow in our “Oligos Made Easy” series.For technical questions or in-depth discussion, the author can be reached at kindler@knauer.net</blockquote>

Oligos Made Easy - Part 2: AEX

News from LabRulezLCMS Library - Week 07, 2026

Article

Application

Plastics

Environment

Science and research

Poster

RECETOX (Research Centre for Toxic Compounds in the Environment) is an independent department of the Faculty of Science of Masaryk University in Brno, which has been established in 1983. RECETOX is focused on the research and education in cross-cutting area of Environment and Health. It addresses interactions among chemicals, environment, and biological systems, including consequences at local, regional, and global levels.

RECETOX - Centrum pro výzkum toxických látek v prostředí

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LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Thermo Scientific Accucore C8 HPLC Columns

Improve separation speed and resolution while maintaining low backpressures using Thermo Scientific™ Accucore™ C8 LC Columns. 

Improve separation speed and resolution while maintaining low backpressures using Thermo Scientific™ Accucore™ C8 LC Columns. Rugged 2.6μm solid-core particles ensure high efficiencies and enable compatibility with both HPLC and UHPLC platforms.&nbsp;The high coverage C8 bonded phase provides optimal retention of analytes with moderate hydrophobicity. Robust bonding technology and automated packing procedures ensure excellent reproducibility and long column lifetimes.<h5>Lower Hydrophobic Retention</h5><ul><li>Recommended for moderately hydrophobic analytes or for when a less hydrophobic phase provides optimum retention</li></ul><h5>Fast Separations</h5><ul><li>2.6μm core-enhanced technology particles enable operation at high flow rates without generating excessive backpressures.</li></ul><h5>Excellent Peak Shapes for Enhanced Resolution and Sensitivity</h5><ul><li>Solid core 2.6μm particles and narrow particle size distribution reduce band broadening and improve separation efficiencies.</li><li>High surface coverage of silica minimizes secondary interactions and peak tailing.</li></ul><h5>Low Backpressures</h5><ul><li>Solid core 2.6μm particles for less backpressure compared to UHPLC sub-2μm particles</li><li>Compatible with conventional HPLC instrumentation and UHPLC platforms</li></ul><h5>Excellent Reproducibility and Robustness</h5><ul><li>Advanced bonding technology</li><li>Automated packing process</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>For Use With: HPLC</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Stationary Phase: C8</li><li>Surface Area: 130 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L7</li><li>Carbon Load: 5%</li><li>Phase: Reversed Phase</li><li>Pore Size: 80 Å</li><li>pH: 2 to 9</li></ul>

Thermo Scientific Accucore aQ C18 Polar Endcapped HPLC Columns

Separate polar compounds with improved speed and resolution using Thermo Scientific™ Accucore™ aQ C18 Polar Endcapped LC columns.

Separate polar compounds with improved speed and resolution using Thermo Scientific™ Accucore™ aQ C18 Polar Endcapped LC columns. Rugged 2.6μm solid-core particles enable fast, high-efficiency separations at low backpressures.The polar endcapped C18 stationary phase provides optimal retention of polar analytes and is fully compatible with 100% aqueous mobile phases. Robust bonding technology and automated packing procedures ensure excellent reproducibility and long column lifetimes.<h5>Alternative Selectivity</h5><ul><li>Polar endcapped C18 stationary phase provides optimum retention of polar analytes</li><li>Accucore aQ Columns are compatible with highly aqueous mobile phases.</li><li>Polar encapping allows use in 100% aqueous mobile phases without loss of performance or stability.</li></ul><h5>Fast Separations</h5><ul><li>2.6μm core-enhanced technology particles enable operation at high flow rates without generating excessive backpressures.</li></ul><h5>Excellent Peak Shapes for Enhanced Resolution and Sensitivity</h5><ul><li>Solid-core 2.6μm particles and narrow particle size distribution reduce band broadening and improve separation efficiencies.</li><li>High surface coverage of silica minimizes secondary interactions and peak tailing.</li></ul><h5>Low Backpressures</h5><ul><li>Solid-core 2.6μm particles for less backpressure compared to UHPLC sub-2μm particles</li><li>Compatible with conventional HPLC instrumentation and UHPLC platforms</li></ul><h5>Excellent Reproducibility and Robustness</h5><ul><li>Advanced bonding technology</li><li>Automated packing process</li></ul><h4>Specifications</h4><ul><li>Endcapped: Polar</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Particle Shape: Spherical Solid Core</li><li>Stationary Phase: C18</li><li>Surface Area: 130 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L1</li><li>Carbon Load: 9%</li><li>Phase: Reversed Phase</li><li>Pore Size: 80 Å</li><li>pH: 2 to 9</li></ul>

Thermo Scientific Accucore Polar Premium HPLC Columns

Achieve fast, high-resolution separations of polar and nonpolar analytes using Thermo Scientific™ Accucore™ Polar Premium LC columns.

Achieve fast, high-resolution separations of polar and nonpolar analytes using Thermo Scientific™ Accucore™ Polar Premium LC columns. Rugged 2.6μm solid-core particles enable fast, high-efficiency separations at low backpressures.&nbsp;The robust amide-embedded C18 stationary phase provides unique selectivity complementary to conventional C18 columns, is stable from pH 1.5–10, and is fully compatible with highly aqueous mobile phases. Robust bonding technology and automated packing procedures ensure excellent reproducibility and long column lifetimes.<h5>Alternative Selectivity</h5><ul><li>Polar embedded reverse phase material offers complementary selectivity to standard C18 columns.</li></ul><h5>Stable over Wide pH Range</h5><ul><li>Specially designed bonded phase is stable from pH 1.5–10.5.</li></ul><h5>Compatible with Highly Aqueous Mobile Phases</h5><ul><li>Rugged amide-embedded C18 phase will not undergo phase collapse in 100% aqueous mobile phase.</li></ul><h5>Fast Separations</h5><ul><li>2.6μm core-enhanced technology particles enable operation at high flow rates without generating excessive backpressures.</li></ul><h5>Excellent Peak Shapes for Enhanced Resolution and Sensitivity</h5><ul><li>Solid-core 2.6μm particles and narrow particle size distribution reduce band broadening and improve separation efficiencies.</li><li>High surface coverage of silica minimizes secondary interactions and peak tailing.</li></ul><h5>Low Backpressures</h5><ul><li>Solid-core 2.6μm particles for less backpressure compared to UHPLC sub-2μm particles</li><li>Compatible with conventional HPLC instrumentation and UHPLC platforms</li></ul><h5>Excellent Reproducibility and Robustness</h5><ul><li>Advanced bonding technology</li><li>Automated packing process</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Particle Shape: Spherical Solid Core</li><li>Stationary Phase: Polar Embedded</li><li>Surface Area: 90 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L60</li><li>Carbon Load: 9%</li><li>Phase: Reversed Phase</li><li>Pore Size: 150 Å</li><li>pH: 1.5 to 10.5</li></ul>

Thermo Scientific Accucore Phenyl-Hexyl HPLC Columns

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Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer confidently and routinely characterize, quantify, and confirm in a single analysis using a single mass spectrometer.

Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.<h5>Superior Quantitation</h5><ul><li>Advanced quadrupole technology (AQT) improves precursor selection and transmission for more-accurate quantitation of low-abundance analytes in complex matrices</li><li>Sophisticated data-independent acquisition (DIA) and parallel reaction monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence</li><li>An advanced active beam guide (AABG) reduces noise and extends maintenance intervals</li></ul><h5>Enhanced Analysis of Intact Proteins</h5><ul><li>Optional intact protein mode provides superior trapping of large molecules for improved analysis of intact proteins and protein complexes</li><li>Optional enhanced resolution ensures maximum ID confidence in top-down proteomics and lipidomics</li></ul><h5>High-Confidence Results</h5><ul><li>HR/AM and full-scan capabilities capture all sample data, all of the time, enabling retrospective data analysis without need to re-run samples</li><li>Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices</li><li>Better than 1-ppm mass accuracy in full- and all-ion fragmentation (AIF) scan modes ensures confident compound identification</li><li>Fast scanning at 12 Hz and spectral multiplexing suited to UHPLC applications</li><li>Rapid polarity switching maximizes information obtained</li><li>AIF and multiple dissociation techniques — in-source CID and HCD — aid in compound identification</li><li>Mass range to 6000 m/z enhances detection of singly charged small molecules and biomolecules</li><li>More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan</li></ul>

Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer

Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS offers ultra-high mass range native MS with top-down capabilities, extreme sensitivity, and resolution up to 80,000 m/z.

<h3>Go beyond what you thought possible with native mass spectrometry</h3>The Thermo Scientific™ Q Exactive™ UHMR is the first hybrid quadrupole-Orbitrap™ mass spectrometer designed specifically for ultra-high mass range (UHMR) native MS and top-down protein analysis. It combines exceptional sensitivity, ultra-high resolution at high m/z, and unique pseudo-MS³ capabilities, enabling detailed characterization of intact protein assemblies and complex biological systems.<h3>🔬 Breakthrough in Native Mass Spectrometry</h3>Native mass spectrometry preserves the non-covalent structure and interactions of proteins and protein complexes, making it an indispensable tool for structural biology and biopharma. The Q Exactive UHMR system enables direct mass analysis of intact macromolecules, including membrane proteins, virus capsids, and ribosomal particles—with unrivaled detail.<ul><li>Ultra-high mass range detection up to 80,000 m/z</li><li>Native top-down analysis of protein complexes and assemblies</li><li>High sensitivity for precious or low-abundance samples</li><li>Resolve mass differences even in heterogeneous megaDalton assemblies</li></ul><h3>⚙️ Technological Innovations</h3>The Q Exactive UHMR system integrates multiple hardware advancements to overcome the historical limitations of native MS:<ul><li>In-source trapping for efficient desolvation and controlled dissociation</li><li>Advanced quadrupole mass filter with selection up to 25,000 m/z</li><li>Reduced RF frequencies across the ion path for better high-mass transmission</li><li>Pseudo-MS³ capability: fragment large complexes into subunits, then sequence them in HCD cell</li></ul><h3>🧬 Applications and Capabilities</h3><h4>Confident characterization of complex biological systems:</h4><ul><li>Virus capsid analysis: Differentiation and sequencing of 3–4 MDa hepatitis B virus capsids</li><li>Ribosome studies: Resolution of substoichiometric proteins in E. coli 70S particles</li><li>Membrane proteins: Gentle liberation from micelles and native top-down sequencing (e.g., AmtB trimer)</li><li>Chaperonin complexes: Native top-down analysis of GroEL tetradecamer</li></ul><h4>Detect and resolve small differences in high-mass species:</h4><ul><li>Post-translational modifications</li><li>Ligand binding</li><li>Protein truncations and isoforms</li></ul><h3>💡 Software for Confident Data Interpretation</h3>Maximize the power of native MS with industry-leading software:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837">BioPharma Finder™ Software </a>– For intact mass confirmation, top-down analysis, and PTM localization</li><li>ProSightPC™ Software – Advanced top-down proteomics with integrated UniProt database search</li></ul><h3>🧪 Who Is It For?</h3>Ideal for research groups and industry labs focused on:<ul><li>Structural biology</li><li>Biotherapeutic development</li><li>Native and top-down proteomics</li><li>Protein-ligand interaction studies</li></ul><h3>🧭 Summary of Key Features</h3><ul><li>Mass range: Up to 80,000 m/z</li><li>Quadrupole isolation: Up to 25,000 m/z</li><li>Sensitivity: Orders of magnitude higher at high m/z</li><li>Fragmentation: HCD, pseudo-MS3 for native top-down</li><li>In-source trapping: Yes, optimized for membrane protein assemblies</li><li>Software: BioPharma Finder, ProSightPC</li><li>Compatible analyses: Native MS, top-down, intact mass, charge detection</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp" alt="Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/thumbnail_Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp 156w," sizes="100vw" width="650" height="650">

Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer

Know your unknown compounds with confidence, using intelligent mass spectrometry that combines ease-of-use with smart acquisition methods to deliver higher data certainty.

Designed to unravel complex chemical structures while delivering the highest versatility and comprehensive workflow support for unknown compound ID and small molecule analysis, the Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ mass spectrometer empowers you to collect more meaningful data.Combining industry-leading mass analyzer technology analysis with intelligent acquisition, intuitive software and remote, hands free calibration, discover a new level of improved confidence in structure elucidation, with on-the-fly identification of small molecules to reveal more chemical structures with ease.The Orbitrap IQ-X Tribrid MS seamlessly integrates with industry-leading solutions to provide a complete workflow solution, including Thermo Scientific™ Vanquish™ Duo UHPLC Systems, Thermo Scientific™ FAIMS Pro Duo interface for differential ion mobility, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759">Thermo Scientific™ Compound Discoverer™ data analysis software</a>, and the most comprehensive spectral libraries available on <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764">Thermo Scientific™ mzCloud™</a>, enabling an intelligent MSⁿ data acquisition strategy to easily conduct small molecule structural elucidation, identification, and characterization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp 238w," sizes="100vw" width="1447" height="949"><h5>Other benefits of this mass spectrometry system include:</h5><ul><li>A combination of the best of quadrupole, linear ion trap and Thermo Scientific™ Orbitrap™ mass analyzer technology for acquisition of the richest MSⁿ data per sample.</li><li>Spend more time on results, less time on instrument set-up with the new Auto-Ready ion source for remote, hands free calibration, combined with the Thermo Scientific™ EASY-IC™ (Internal Calibration) source to deliver superior mass accuracy in every scan, mass calibration can be fully automated, increasing productivity.</li><li>Real-Time Library Search provides higher confidence small molecule analysis using on-the-fly spectral matching for decision-based triggering of MSⁿ scan events that increase certainty.</li><li>Expanded <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1763">Thermo Scientific™ AcquireX workflow</a> capabilities provide easy and intelligent acquisitions to find more compounds by integrating independent experiments into an automated workflow for efficient and comprehensive sample and study characterization.</li><li>Flexible fragmentation choices for structural determination of lipids, metabolites, and other small molecules utilizing Collision induced dissociation (CID), Higher-energy collisional dissociation (HCD) and optional Ultraviolet Photodissociation (UVPD).</li><li>Improved unknown analysis and fine isotope detection with optional 1,000,000 (1M) FWHM resolution at m/z 200.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1880" height="822"><h3>Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer Specifications</h3><ul><li>Dimensions (D x W x H): 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li>Dynamic Range: &gt;5000 within a single scan</li><li>Mass Accuracy:&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li>Polarity Switching: One Full Cycle in 1.1 sec</li><li>Scan Rates:&nbsp;<ul><li>OTMSⁿ: Up to 40 Hz</li><li>ITMSⁿ: Up to 45 Hz</li></ul></li><li>Weight (Metric): 318 kg (700 lb.)</li><li>Mass Range: Full MS Mass Range: 50 to 2000 m/z to MSⁿ Mass Range: 40 to 2000 m/z</li><li>Max. Resolution: Up to 500,000 at m/z 200</li><li>Resolution:&nbsp;<ul><li>7500 to 500,000 (FWHM) at m/z 200</li><li>1M Option: up to 1,000,000 (FWHM) at m/z 200</li></ul></li><li>Type: Orbitrap IQ-X Tribrid MS IC</li><li>Unit Size: Each</li></ul>

Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer

With enhanced performance and usability, the Orbitrap Eclipse Tribrid MS makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.

Introducing the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer, our newest generation instrument designed with your most difficult analytical challenges in mind. With enhanced performance and usability, the Orbitrap Eclipse Tribrid mass spectrometer makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.Obtain high confidence insights for very complex molecules with the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer. It combines industry-leading versatility and usability with the exceptional performance afforded by its built-in intelligence and revolutionary Thermo Scientific™ Tribrid™ architecture to deliver an instrument designed to address the most difficult analytical challenges.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp 245w," sizes="100vw" width="596" height="310"><h5>This newest Tribrid platform includes:</h5><ul><li>Advanced Ion Management Technology (AIM+) with the new QR5 segmented quadrupole mass filter</li><li>Real-Time Search</li><li>Enhanced Vacuum Technology</li><li>Optional Proton Transfer Charge Reduction (PTCR)</li><li>Optional High Mass Range MSⁿ (HMRⁿ) mode</li></ul><h5>Collectively, these features make this instrument uniquely suited for:</h5><ul><li>Accurate and high-throughput full-proteome quantitation</li><li>Characterization of complex mixtures of protein or small molecule-based pharmaceuticals</li><li>Deciphering higher-order protein structures</li></ul>The Orbitrap Eclipse Tribrid MS makes it easy to tackle these difficult analyses and collect the high-quality data required to drive the right decisions, pushing your science beyond today's discovery.With its built-in intelligence and versatility, the Orbitrap Eclipse Tribrid MS makes it easy to produce the high quality data required to drive the right decisions.<ul><li>Exceptional precursor selectivity and sensitivity with the next generation quadrupole mass filter</li><li>Unmatched depth and accuracy of TMT analysis with novel Real-Time Search</li><li>High Mass Range MSⁿ (HMRⁿ) option for comprehensive analysis of native protein complexes</li><li>Unique Proton Transfer Charge Reduction (PTCR) option for simplifying complex top-down spectra</li><li>Full experimental flexibility with revolutionary instrument control</li><li>A wide range of optional functionalities for unprecedented versatility</li><li>Common user interface with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/401">Thermo Scientific™ Orbitrap Exploris™ 480</a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=TSQ">TSQ™ triple quadrupole mass spectrometers</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1452" height="710"><h3>Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer Specifications</h3><ul><li>Dimensions (D x W x H): 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li>Dynamic Range: &gt;5000 with a single OTMS spectrum</li><li>Mass Accuracy:&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li>Model: Tribrid MS</li><li>Polarity Switching: One Full Cycle in &lt; 1.1 sec</li><li>Scan Rates:&nbsp;<ul><li>OTMSⁿ: Up to 40 Hz</li><li>ITMSⁿ: Up to 45 Hz</li></ul></li><li>Weight (Metric): 180 kg (400 lb.)</li><li>Mass Range:&nbsp;<ul><li>Standard mass range: 50 to 2000 m/z</li><li>Mid mass range: 200 to 6000 m/z</li><li>Optomenal HMRⁿ mass range: 500 to 8000 m/z</li></ul></li><li>Max. Resolution: Up to 500,000 at m/z 200</li><li>Type: Orbitrap LC-MS</li><li>Unit Size: Each</li></ul>

Thermo Scientific Chromeleon CDS Enterprise

Chromeleon CDS Enterprise is a scalable, cloud-ready chromatography data system for multi-site labs. Ensures compliance, connectivity, uptime, and productivity.

A Chromatography Data System (CDS), networked or enterprise, is vital for compliant, efficient and reliable operation of any modern chromatography laboratory – it will manage all the analytical processes from instrument control, to raw data storage and processing, right through to generating the final results.Delivering these capabilities across a network brings a unique set of challenges. <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ CDS</a> has been designed and optimized to overcome these challenges. The Chromeleon software architecture can connect multiple sites and locations to a central data center with the same performance as a fully local operation. With its forward-looking architecture Chromeleon CDS is cloud-ready today.Chromeleon software supports your chromatography operation throughout your enterprise – from research to routine quality testing – connecting people, instruments and other laboratory software, while delivering proven productivity gains for faster return on investment (ROI).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/Thermo-Chromeleon-CDS-Enterprise-2.jpg" alt="Thermo Scientific Chromeleon CDS Enterprise" width="null" height="null"><h3>Chromeleon CDS brings…</h3><h4>…compliance</h4><ul><li>Highest degree of data integrity and traceability with comprehensive security tools</li><li>eReports and eSignatures ensure regulatory compliance</li><li>Automated software and instrument qualification routines and qualification monitoring</li><li>Supports GLP, GMP and 21 CFR Part 11 regulatory requirements</li><li>Complete audit trails with versioning and advanced review functions</li></ul><h4>…connectivity</h4><ul><li>Built for scalable network deployment</li><li>Utilize instruments suiting your business’s needs</li><li>Easily interface with relevant laboratory software (including LIMS/ELN)</li><li>Chromeleon SDK available for custom integrations</li><li>Cloud-ready with central management and simplified deployment</li></ul><h4>…confidence</h4><ul><li>Unique network failure protection ensures 24/7 laboratory uptime</li><li>Future proof and scalable software solution</li><li>Access to up-to-date laboratory performance information</li><li>XVault technology enables operation even during network outages</li><li>Automatic instrument and software qualification checks</li></ul><h4>…productivity</h4><ul><li>Increased efficiency via toolset providing ‘right first time’ analysis</li><li>Reduced data processing time using built-in smart tools</li><li>eWorkflow™ procedures, Smart Startup, IRC and SST automation</li><li>SmartLink, Cobra Wizard and batch processing tools for fast, reliable data review</li><li>Fully customizable Report Designer and structured reporting templates</li></ul>

Thermo Scientific Vanquish Duo UHPLC Systems

A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance.

<h3>Optimize your productivity</h3>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;At the same time, advancements and innovations are needed to improve operational efficiency and performance. How do you accomplish this? It’s easy with the Thermo Scientific™ Vanquish™ High-throughput LC systems built for enhanced productivity. Vanquish High-throughput LC systems combine individual Vanquish components and software wizards to deliver increased throughput or detector utilization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"><h3>Two flow paths for maximized productivity</h3>Your laboratory may be facing increased pressure to improve working efficiency and deal with limiting resources, such as budget, space, or manpower. Vanquish High-throughput LC systems are designed to overcome these limitations by providing multiple flow paths for parallelization of specific stages of the LC run.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"><h4>Unique dual technology</h4>The Vanquish platform contains two unique dual modules. Vanquish dual pumps merge two individual, low pressure mixing pumps in one housing enabling separate eluents and gradients for each pump.Vanquish dual split samplers possess two independently controlled injection units including separate injection valves and injection needles. Used in Dual LC and LC-MS workflows only, this enables high throughput and extensive sample characterization workflows.<h3>Two configurations to best serve your needs</h3>Vanquish High-throughput workflows are configured with Thermo Scientific™ Vanquish™ Core system, Thermo Scientific™ Vanquish™ Flex system or Thermo Scientific™ Vanquish™ Horizon system modules. Both workflows make use of two pumps to increase instrument productivity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"><h4>Vanquish Duo UHPLC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li>Sampler: Dual split sampler</li><li>Detector: Two out of the complete detector portfolio</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4>Vanquish Tandem LC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li>Sampler: Split sampler</li><li>Detector: One out of the complete detector portfolio and/or one mass spectrometer</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3>Vanquish Duo UHPLC systems</h3>A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance. The unique Vanquish Duo UHPLC system will:<ul><li>Improve return on investment by reducing cost per sample</li><li>Increase sample throughput without changing validated methods</li><li>Increase capacity without sacrificing bench space</li><li>Accelerate your method development process</li><li>Analyze the same set of samples with multiple methods, reducing sample preparation time and maximizing sample knowledge</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg 245w," sizes="100vw" width="1678" height="512"><h4>What can you do with a Vanquish Duo UHPLC system?</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: What can you do with a Vanquish Duo UHPLC system?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg 245w," sizes="100vw" width="1604" height="658"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two independent assays run simultaneously from a single sample on one LC instrument to deepen your sample knowledge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg 245w," sizes="100vw" width="1372" height="385"><h4>Complete control with just a few clicks</h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a> delivers industry-leading ease-of-use for the Vanquish Duo system. Independently control the two channels of the Vanquish Duo system from a single interface with full traceability of all actions that is 21 CFR Part 11 compliant.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Easy-to-use and intuitive system control of the Dual LC workflow within Chromeleon CDS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg 245w," sizes="100vw" width="1190" height="632"><h3>See the Vanquish Duo UHPLC system</h3>The Vanquish Duo UHPLC system has been built to utilize a wide range of analytical detectors, including mass spectrometry (MS), diode array detection (DAD), charged aerosol detection (CAD), variable wavelength detection (VWD), and fluorescence detection (FLD).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: See the Vanquish Duo UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg 174w," sizes="100vw" width="939" height="841"><h5>1. Vanquish Solvent Monitor</h5>Use the Vanquish Solvent Monitor to increase your regulatory compliance, productivity, and safety of your laboratory. That device guarantees that your HPLC systems will never run dry and the waste will not spill over during your analysis, reducing loss of valuable measurement time and sample material.<h5>2. Vanquish User Interface</h5>With the Vanquish User Interface, you are the master of your LC instrument. The display always shows you the key parameters of your instrument such as flow and pressure and guides you in a visual step-by-step video tutorial through key maintenance tasks.<h5>3. Versatile detection capabilities</h5>Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitate multiple detector methodologies. Vanquish Duo UHPLC systems can be used with any two detectors out of the broad detector portfolio including MS, DAD, VWD, FLD and CAD.<h5>4. Compatible with your software infrastructure</h5>A Vanquish Duo UHPLC system can be operated in various software environments including the latest Chromeleon software feature release, Chromeleon CDS long-term, and extended support version and Waters Empower.<h5>5. Versatile column management</h5>Greater column capacity (two 30 cm columns or a greater number of shorter columns per compartment), plus class-leading temperature range and temperature stability.<h5>6. Delivering powerful separations</h5>Run samples with two similar or different columns to increase throughput or maximize output. Setup with optional second compartment for independent column temperatures.<h5>7. Easier operation</h5>Patented tool-free Thermo Scientific™ Viper™ Fingertight Fittings with near-zero dead volume operation and ergonomic design.<h5>8. Unique Thermo Scientific™ SmartInject technology</h5>Superior retention time precision and enhanced column protection with intelligent SmartInject technology on both flow paths.<h5>9. Two proprietary injection valves</h5>Two separate injection valves with no shared fluidics allowing full application flexibility, including individual eluents, wash liquids and loop sizes.<h5>10. Easier sample handling</h5>Automated barcode reader to eliminate tedious rack configuration.<h5>11. Higher sample capacity</h5>High sample capacity is standard (four plates versus two plates on industry average). Increase capacity further with the optional Thermo Scientific™ Vanquish™ Charger module.<h5>12. Accurate flow for more data confidence</h5>The flow is delivered by a dual pump offering two truly individual devices in a single housing with ternary gradient proportioning.<h5>13. Simple maintenance</h5>Module maintenance is reduced to a minimum and can be worked on without instrument de-stacking, plus smart light bars on the front of the system provide instant system status update.<h5>14. Keep the lab tidy</h5>The built-in drawer stores accessories, related documents, or any other useful material for the system.<h3>Thermo Scientific LC portfolio overview</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660">

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