<div><div><div><p><strong>Scientists at IOCB Prague have developed a breakthrough technology that streamlines aptamer development. The new method integrates several biochemical and bioinformatics steps and paves the way for new diagnostic and therapeutic applications. Ongoing applications include wearable sensors that monitor selected biomarkers in real time and provide early warnings of impending health complications. The findings were published in </strong><i><strong>Nature Communications</strong></i><strong>.</strong></p></div></div><div><p>Aptamers are short DNA or RNA strands that can recognize and bind to a specific target molecule with high precision. Similar to antibodies, they can be used to detect these molecules or modulate their activity. Unlike antibodies, they are much more stable, can be produced synthetically, and can be chemically modified to achieve the desired properties. As a result, they can offer capabilities that cannot be achieved with antibodies.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg" alt="IOCHB Prague: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Chemically modified DNA aptamer bound to the target protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg 228w," sizes="100vw" width="1343" height="916"></p><p>As demand grows for accurate and rapid diagnostic tools, aptamers are often better suited to these applications than antibodies. However, developing aptamers is both experimentally demanding and time-consuming. A team of scientists from IOCB Prague, led by Dr. Marek Ondruš and <a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en"><strong>Prof. Michal Hocek</strong></a>, has now developed a technology that significantly shortens the development process.</p><p><i>“Developing an aptamer is often like looking for a needle in a haystack. Among trillions of different DNA sequences, we search for the one that binds strongly and specifically to a target molecule. Our new approach first screen for ‘aptamer families’ – hundreds of related sequences – and then identify the best-performing member of the family. This approach can reduce development time from several months to only a few days,” </i>says Marek Ondruš.</p><blockquote><p><strong>Video:</strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=_3zXUeVMugU"> New technology streamlines the development of aptamers, synthetic alternatives to antibodies&nbsp;</a></p></blockquote><p>The team has also expanded the potential applications of aptamers by chemically modifying their building blocks. For example, introducing functional groups similar to those found naturally in amino acids allows the resulting molecules to combine the advantages of both DNA and antibodies: Their sequence is encoded by the order of nucleotides in DNA, while the attached chemical modifications greatly expand their ability to recognize biologically relevant targets and mimic interactions between proteins that are underlying many biological processes.</p><p>The researchers demonstrated the potential of this new method using the human insulin receptor, a key protein that regulates blood sugar levels. They developed an aptamer that specifically binds to the receptor and elucidated the molecular basis of this interaction using cryo-electron microscopy. <i>“We have shown that chemically introduced functional groups play a crucial role not only in target recognition and formation of the aptamer–protein complex, but also in stabilizing the DNA aptamer’s structure. Our findings provide new insights into how chemically modified nucleic acids can mimic key properties of proteins,”</i> says Marek Ondruš.</p><p>In the future, the technology could complement – or, in some applications, even replace – antibody-based diagnostic tools. Researchers are collaborating with <a target="_blank" rel="noopener noreferrer" href="http://iocbtech.cz/">IOCB Tech</a> on its further development, as the company helps to bring discoveries from IOCB Prague into practical applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg" alt="IOCHB Prague/Tomáš Belloň: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Dr. Marek Ondruš, first author of the study, and Prof. Michal Hocek, head of the Bioorganic and Medicinal Chemistry of Nucleic Acids research group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg 234w," sizes="100vw" width="2000" height="1335"></p><blockquote><h4><strong>Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-73676-y#citeas"><strong>Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries</strong></a></h4><p>ablo Alberto Franco-Urquijo, Marek Ondruš, Jaroslav Kurfürst, Jana Škerlová, Irena Selicharová, Lucie Mužíková Čechová, Hana Šváchová, Alena Semerádtová, Anatolij Filimoněnko, Adéla Fejfarová, Jiří Homola, Tomáš Kouba &amp; Michal Hocek</p><p><i><strong>Nat. Commun., 2026, DOI: 10.1038/s41467-026-73676-y&nbsp;</strong></i></p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41467-026-73676-y"><span>https://doi.org/10.1038/s41467-026-73676-y</span></a><span>&nbsp;</span></p><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable of identifying high-affinity modified aptamers. Double partition followed by amplification of eluted sequences, NGS analysis and clustering provides fast identification of aptamer candidates. Screening of modified DNA libraries containing modified adenine and uracil nucleotides bearing hydrophobic aromatic phenyl and indole moieties results in development of an aptamer binding human insulin receptor with sub-nanomolar affinity and exquisite specificity. Cryo-EM structure reveals the importance of each aromatic modification, either in stabilizing the secondary structure or facilitating interactions with the protein surface. This approach addresses the main drawbacks of aptamer selection and has potential for high-throughput screening and accelerating the development of next-generation aptamers for diagnostics or therapeutics.</p></div>

New technology streamlines the development of aptamers, synthetic alternatives to antibodies

<p><strong>Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity</strong></a><strong> 10.2 highlights</strong></h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4><strong>Instrument control modules</strong></h4><p>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"></p><h4><strong>MS data import/export improvements</strong></h4><p>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"></p><h4><strong>Obsolete hardware support terminated</strong></h4><p>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"></p><blockquote><p><strong>Explore the complete list of all changes, fixes, and additions in version 10.2.</strong></p><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1"><strong>See the complete changelog&nbsp;</strong></a></p></blockquote>

Clarity Chromatography Software 10.2 released!

<p><strong>🎤Dr. Leigh Terry (University of Alabama)</strong></p><p><strong>In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.</strong></p><p>While most regulatory methods focus on a small number of compounds like PFOA and PFOS, there may be thousands of PFAS compounds in the environment—and much of that burden goes undetected.</p><h4><strong>In this episode, we cover:</strong></h4><ul><li>Why PFAS are called “forever chemicals” (and why that label is evolving)</li><li>The limitations of targeted<strong> LC-MS/MS methods</strong></li><li>What the fluorine mass balance problem reveals about PFAS destruction</li><li>How combustion ion chromatography (<strong>CIC</strong>) helps measure total organofluorine</li><li>Why “99.99% removal” doesn’t always mean what you think</li><li>Where PFAS actually end up in wastewater treatment systems</li><li>The most effective technologies for PFAS removal today</li><li>Why drinking water may only account for ~20% of total PFAS exposure</li></ul><h4><strong>Key Insight:</strong></h4><p>Even when analyzing dozens of PFAS compounds, researchers may only be capturing a small fraction of total organic fluorine—raising major questions about how we monitor and regulate these contaminants.</p><h3><strong>Video Transcription</strong></h3><p>In this episode of <i>Concentrating on Chromatography</i>, Dr. Leigh Terry discusses PFAS contamination in drinking water, the analytical challenges associated with measuring these compounds, current treatment technologies, and future directions for monitoring and regulation. The conversation highlights how analytical chemistry, environmental engineering, and public health intersect in addressing one of today's most discussed classes of emerging contaminants.</p><h4><strong>Understanding PFAS and Their Significance</strong></h4><h5><strong>The University of Alabama Water Quality Research Center</strong></h5><p>Dr. Leigh Terry is part of the University of Alabama's Center for Water Quality Research. The center operates an analytical laboratory focused on drinking water quality and the detection of contaminants at extremely low concentrations.</p><p>The laboratory specializes in:</p><ul><li>Drinking water analysis</li><li>Organic contaminants</li><li>Emerging contaminants</li><li>PFAS monitoring</li><li>Water quality research</li></ul><p>Their work supports both research initiatives and practical solutions for water utilities and environmental agencies.</p><h4><strong>Why Focus on PFAS?</strong></h4><p>Although PFAS compounds have existed since the 1940s, public awareness has increased dramatically only in recent years.</p><p>According to Dr. Terry, several factors contributed to the rapid growth of PFAS research:</p><ul><li>Increased media attention</li><li>New regulatory initiatives</li><li>Growing evidence of human exposure</li><li>Expanding research opportunities</li><li>Greater understanding of potential health risks</li></ul><p>PFAS are not new contaminants. Rather, society is only beginning to understand their prevalence in the environment and their potential impacts on human health.</p><h4><strong>The Development of Standardized PFAS Methods</strong></h4><p>One major advancement in PFAS analysis has been the development of standardized EPA methods.</p><p>These methods allow:</p><ul><li>Consistent testing procedures</li><li>Comparable results between laboratories</li><li>Regulatory monitoring</li><li>Reliable data interpretation</li></ul><p>Dr. Terry notes that many of these standardized approaches began appearing around 2018–2019, providing a common framework for analytical laboratories and researchers.</p><h4><strong>How Large Is the PFAS Universe?</strong></h4><p>Many people are familiar with PFOA and PFOS, two of the most heavily studied PFAS compounds. However, these represent only a small fraction of the broader PFAS family.</p><p>PFOA and PFOS are often referred to as:</p><ul><li>Legacy PFAS compounds</li><li>Original PFAS contaminants</li><li>Early commercial PFAS chemicals</li></ul><p>The challenge is that even minor modifications to molecular structure create entirely new PFAS compounds.</p><p>Researchers estimate:</p><ul><li>Thousands of PFAS compounds exist</li><li>Some estimates exceed 10,000 compounds</li><li>Exact numbers depend on how PFAS are defined</li></ul><p>Scientific debate continues regarding classification and definition, making precise counting difficult.</p><h4><strong>Why PFAS Are Called "Forever Chemicals"</strong></h4><p>Dr. Terry notes that the phrase "forever chemicals" has become widely used, although she suggests the terminology could benefit from rebranding.</p><p>PFAS persistence results from two key chemical properties.</p><h5><strong>1. Amphiphilic Structure</strong></h5><p>PFAS molecules contain:</p><ul><li>A water-loving (hydrophilic) head group</li><li>A water-repelling (hydrophobic) fluorinated tail</li></ul><p>This unusual combination allows PFAS to partition between:</p><ul><li>Water</li><li>Solids</li><li>Air-water interfaces</li><li>Foam</li></ul><p>Unlike many organic compounds, PFAS can interact effectively with multiple environmental phases.</p><h5><strong>2. Extremely Strong Carbon–Fluorine Bonds</strong></h5><p>The carbon–fluorine bond is among the strongest bonds in organic chemistry.</p><p>As Dr. Terry explains:</p><ul><li>Large amounts of energy are required to break these bonds</li><li>Natural degradation processes are often ineffective</li><li>Destruction can require highly aggressive treatment conditions</li></ul><p>These properties make PFAS extremely persistent in both environmental systems and biological organisms.</p><h4><strong>Toxicity, Regulations, and Environmental Behavior</strong></h4><h5><strong>Understanding PFAS Toxicity</strong></h5><p>One of the biggest challenges in PFAS regulation is the incomplete understanding of toxicity.</p><p>Dr. Terry explains that EPA regulations generally consider three factors:</p><ul><li>Presence in drinking water sources</li><li>Toxicity to humans</li><li>Availability of practical treatment options</li></ul><p>While some PFAS compounds are known to be harmful, many others remain insufficiently studied. Furthermore, PFAS often occur as mixtures rather than individual compounds.</p><p>This creates important scientific questions:</p><ul><li>What is the toxicity of individual PFAS?</li><li>What is the toxicity of PFAS mixtures?</li><li>How should cumulative exposure be evaluated?</li></ul><p>These uncertainties continue to drive active research.</p><h4><strong>What Happens to PFAS in Wastewater Treatment Plants?</strong></h4><p>PFAS do not behave like many conventional contaminants.</p><p>Rather than remaining fully dissolved in water, they often accumulate at interfaces such as:</p><ul><li>Water-solid interfaces</li><li>Water-air interfaces</li><li>Foam layers</li><li>Biological solids</li></ul><p>As a result:</p><ul><li>Some PFAS accumulate in biosolids</li><li>Some partition into foam</li><li>Some remain in treated effluent</li></ul><p>Their distribution depends on wastewater composition and treatment processes.</p><h4><strong>Regulatory Monitoring and Targeted LC-MS Analysis</strong></h4><p>Current EPA regulations focus on targeted analysis of specific PFAS compounds.</p><p>Examples include:</p><ul><li>PFOA</li><li>PFOS</li></ul><p>Drinking water regulations currently establish maximum contaminant levels (MCLs) for these compounds at extremely low concentrations.</p><p>Advantages of targeted LC-MS analysis include:</p><ul><li>Clearly defined analytes</li><li>Established regulatory limits</li><li>High analytical sensitivity</li><li>Reliable quantitation</li></ul><p>However, limitations remain:</p><ul><li>Only a small subset of PFAS is measured</li><li>Many PFAS compounds remain undetected</li><li>Total PFAS burden may be underestimated</li></ul><p>As Dr. Terry notes, targeted analysis provides only part of the overall picture.</p><h4><strong>The Fluorine Mass Balance Problem</strong></h4><p>One of the most important concepts discussed in the interview is fluorine mass balance.</p><p>When PFAS degrade, fluorinated fragments may remain in the environment.</p><p>This creates a critical question:</p><p>Are treatment technologies truly destroying PFAS, or merely transforming them into shorter-chain PFAS compounds?</p><p>To answer this, researchers perform fluorine mass balance calculations using:</p><ul><li>Targeted PFAS analysis</li><li>Fluoride measurements</li><li>Total organic fluorine measurements</li></ul><p>A successful destruction process should ultimately convert PFAS into fluoride ions rather than simply producing smaller PFAS molecules.</p><h4><strong>Advanced Analysis, Treatment Technologies, and Future Directions</strong></h4><h5><strong>Combining Targeted and Bulk Fluorine Measurements</strong></h5><p>Dr. Terry's group complements targeted LC-MS analysis with measurements of total organic fluorine.</p><p>Approaches include:</p><ul><li>Absorbable Organic Fluorine (AOF)</li><li>Extractable Organic Fluorine (EOF)</li><li>Combustion Ion Chromatography (CIC)</li></ul><p>In these methods:</p><ul><li>Organic fluorine is captured</li><li>Samples are combusted</li><li>Released fluoride is quantified</li></ul><p>This provides insight into total fluorinated content, although contributions may originate from sources beyond PFAS, including pharmaceuticals and consumer products.</p><h4><strong>Surprising Findings from Combined Analysis</strong></h4><p>One important finding from wastewater studies was that targeted PFAS measurements accounted for only a small fraction of total organic fluorine.</p><p>Dr. Terry reports that:</p><ul><li>Approximately 4% of measured AOF could be explained by targeted PFAS compounds</li><li>The majority of organic fluorine remained unidentified</li></ul><p>This suggests that environmental fluorine chemistry is considerably more complex than currently represented by routine monitoring programs.</p><h4><strong>Preventing PFAS Contamination in the Laboratory</strong></h4><p>PFAS analysis requires exceptionally strict quality control.</p><p>Dr. Terry's laboratory routinely:</p><ul><li>Tests every new batch of SPE cartridges</li><li>Tests carbon tubes before use</li><li>Uses DI water blanks</li><li>Verifies consumables labeled as PFAS-free</li><li>Collects field blanks</li><li>Monitors analytical blanks throughout workflows</li></ul><p>These practices help prevent contamination from laboratory materials and consumables, a common challenge in ultra-trace PFAS analysis.</p><h4><strong>Current PFAS Treatment Technologies</strong></h4><p>Three technologies currently dominate PFAS removal in drinking water treatment:</p><ul><li>Granular Activated Carbon (GAC)</li><li>Ion Exchange Resins</li><li>Reverse Osmosis (RO)</li></ul><p>Selection depends on:</p><ul><li>PFAS concentration</li><li>Water quality</li><li>Local operating conditions</li><li>Utility infrastructure</li></ul><p>Although many emerging technologies are being investigated, these remain the most widely implemented solutions.</p><h4><strong>Membrane Filtration and Pretreatment</strong></h4><p>Dr. Terry collaborates with colleagues studying membrane-based PFAS treatment.</p><p>Her own work focuses on pretreatment through biological filtration.</p><p>The strategy involves:</p><ul><li>Removing natural organic matter</li><li>Reducing membrane fouling</li><li>Improving membrane performance</li><li>Extending operational efficiency</li></ul><p>This integrated approach demonstrates how multiple treatment technologies can work together to improve PFAS removal.</p><h4><strong>Regional Monitoring Projects</strong></h4><p>The University of Alabama team participates in EPA-supported monitoring efforts along the Gulf Coast.</p><p>Their observations indicate:</p><ul><li>PFAS rarely occur alone</li><li>Multiple PFAS compounds frequently co-occur</li><li>Contamination often originates from identifiable point sources</li></ul><p>Examples include:</p><ul><li>Industrial facilities</li><li>Manufacturing operations</li><li>Military installations</li><li>Carpet manufacturing facilities</li></ul><p>Source identification remains a critical component of environmental monitoring programs.</p><h4><strong>Future Directions for PFAS Monitoring</strong></h4><p>Looking ahead, Dr. Terry sees several opportunities for improvement.</p><p>Desired advances include:</p><ul><li>In situ monitoring technologies</li><li>Portable detection systems</li><li>Reduced analytical complexity</li><li>Lower instrument costs</li><li>Less expensive consumables</li><li>Faster analysis workflows</li></ul><p>Current PFAS testing requires substantial expertise, specialized instrumentation, and rigorous quality control, making widespread implementation challenging.</p><h4><strong>Dr. Terry's Perspective on Long-Term Solutions</strong></h4><p>When asked what major PFAS challenge she would most like to solve, Dr. Terry offered a broader perspective.</p><p>Rather than focusing solely on remediation, she emphasized prevention.</p><p>Her view is that society should:</p><ul><li>Better evaluate chemical toxicity before commercialization</li><li>Assess risks before large-scale deployment</li><li>Reduce introduction of harmful compounds into the environment</li><li>Support utilities tasked with contaminant removal</li></ul><p>She notes that water utilities often bear the responsibility of removing contaminants they did not create, highlighting the need for broader societal and regulatory support.</p><h4><strong>Final Thoughts</strong></h4><p>Dr. Terry encourages consumers to:</p><ul><li>Learn where their drinking water originates</li><li>Read annual water quality reports</li><li>Stay informed about local water quality</li><li>Consider appropriate home filtration where needed</li></ul><p>At the same time, she emphasizes confidence in municipal water systems and the importance of continued investment in water quality research, monitoring, and treatment technologies.</p><h4><strong>Conclusion</strong></h4><p>PFAS remain one of the most complex challenges in environmental chemistry and water treatment. Through advanced analytical methods such as LC-MS/MS, combustion ion chromatography, fluorine mass balance approaches, and large-scale monitoring programs, researchers like Dr. Leigh Terry are helping improve our understanding of these persistent contaminants.</p><p>The interview highlights that solving the PFAS challenge will require a combination of better analytical tools, improved treatment technologies, stronger regulatory frameworks, and a greater emphasis on prevention before contaminants enter the environment.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

PFAS in Water: Why We’re Missing 96% of the Problem

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Shimadzu UV-1900i Plus UV-VIS spectrophotometer

UV-1900i Plus delivers 1 nm resolution, ultra-fast scanning, and intuitive operation for precise UV-Vis analysis compliant with JP, USP, and EP.

Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer

Shimadzu UV-2600i Plus and UV-2700i Plus spectrophotometers deliver high performance with flexible wavelength ranges, advanced optics, and efficient software control.

<h4><strong>Versatile, Expandable Mid-Range UV Spectrophotometers for Diverse Applications</strong></h4><section><section><section><ul><li><strong>The UV-2600i Plus </strong>is a<strong> single monochromator system </strong>with an <strong>expandable wavelength range up to 1400 nm </strong>using an optional integrating sphere, making it adaptable for various needs.</li><li><strong>The UV-2700i Plus </strong>is a <strong>double monochromator system capable of 8-Abs measurements</strong>, ideal for low transmittance samples.</li></ul><p>Both models come equipped with the intuitive <strong>Shimadzu LabSolutions UV-Vis software</strong>, ensuring data integrity and ease of use. Additionally, these spectrophotometers can be <strong>scheduled to shut down or enter sleep mode </strong>to save power and lamp life, and can <strong>automatically wake up at a specified time</strong>, enhancing efficiency. Elevate your analysis with these versatile and efficient spectrophotometers.</p><h3><strong>Features</strong></h3><h3><strong>Perfect for a Wide Variety of Applications</strong></h3><p>The functionality of the <strong>UV-2600i Plus /2700i Plus</strong> can be freely expanded to suit the measurement objective. By accommodating a wealth of accessories, the system can address any user’s applications and a variety of situations. Thanks to intuitive operations, anyone can easily obtain the data required.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_e5efa72f19.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_e5efa72f19.jpg 245w," sizes="100vw" width="1040" height="561"></p><h5><strong>Single monochromator UV-2600i Plus</strong></h5><p><strong>A key feature</strong> of the UV-2600i Plus equipped with a single monochromator is its<strong> measurement wavelength range</strong>. By using the optional ISR-2600Plus Integrating Sphere attachment, the measurement wavelength range can be extended from<strong> 220 nm to 1400 nm</strong>, significantly expanding its applications.</p><p><strong>Integrating Sphere Enables Measurements to 1400 nm</strong></p><p>The<strong> UV-2600i Plus</strong> is equipped with <strong>Shimadzu's proprietary LO-RAY-LIGH™ grade diffraction grating</strong>, which achieves high efficiency and low stray light levels. By installing the ISR-2600Plus two-detector integrating sphere, the <strong>300 nm to 1100 nm</strong> wavelength range of conventional models can be extended to <strong>1400 nm</strong>. In addition, the UV-2600i achieves a significant noise reduction, and can accommodate measurements of solar cell anti-reflective films and polycrystalline silicon wafers.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_11_40f2d1e598.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_11_40f2d1e598.jpg 245w," sizes="100vw" width="365" height="228"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_12_b71fa50d8f.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_12_b71fa50d8f.jpg 245w," sizes="100vw" width="1052" height="433"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_13_6adf0a1565.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_13_6adf0a1565.jpg 245w," sizes="100vw" width="1052" height="466"></p><h4><strong>Measures Slight Differences in Absorbance</strong></h4><p>Equipped with a double monochromator that achieves ultra-low stray light levels, the <strong>UV-2700i Plus</strong> is optimal for measuring low transmittance samples, such as polarization films used for LCD panels. The UV-2700i Plus is capable of <strong>8 Abs measurements</strong>, and can make accurate transmittance measurements to 1 part in 100 million, accommodating a variety of sample measurements.</p><p><strong>Achieves Ultra-Low Stray Light, Enabling 8-Abs Measurements</strong></p><p>In the case of a device equipped with a general double monochromator, the absorbance that can be covered is about<strong> </strong>5 to 6, but the UV-2700i Plus offers a range to 8 Abs, with a transmittance value of <strong>0.000001 %</strong> (1 part in 100 million). This system achieves high-level absorbance measurements with incomparable precision. In addition to measuring even high-concentration samples as is, eliminating the need to dilute samples, the system can be applied to evaluating the transmission characteristics of polarization films. Wavelengths in the<strong> 400 nm to 650 nm range</strong> can be measured to 8 Abs.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_16_a08f314ee7.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_16_a08f314ee7.jpg 164w," sizes="100vw" width="511" height="485"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_14_0d004ee208.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_14_0d004ee208.jpg 245w," sizes="100vw" width="1052" height="466"></p><p><strong>Sample Polarization Film Measurement</strong></p><p>With the rotating film holder (image below), two film samples can be set on the same optical axis. In this example, the polarization film is rotated in the plane, and the transmittance is measured when the film transmits and blocks light.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_1_5ff393836a.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_1_5ff393836a.jpg 163w," sizes="100vw" width="397" height="381"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_2_f293cd4e0e.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_2_f293cd4e0e.jpg 184w," sizes="100vw" width="450" height="381"></p><h4><strong>Enables Compliance with ER/ES Regulations and Stronger Data Management</strong></h4><div><div><p><strong>Compatible with Validation from PC Software</strong></p><p>Validation can be implemented with PC software using UV validation software. In addition to simplifying daily inspections, this makes instrument performance checks and records management easier, enabling more secure regulatory compliance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_1900i_Plus_UV_VIS_spectrophotometer_18_1aa29e9a5d.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_1900i_Plus_UV_VIS_spectrophotometer_18_1aa29e9a5d.jpg 232w," sizes="100vw" width="450" height="302"></p><ul><li>Inspection results can not only be printed but also saved to a file, so the results can be called up later for confirmation.</li><li>The inspection parameters can also be saved to separate files for periodic and routine inspections and then called up for use.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_1900i_Plus_UV_VIS_spectrophotometer_19_7395087cba.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_1900i_Plus_UV_VIS_spectrophotometer_19_7395087cba.jpg 232w," sizes="100vw" width="450" height="302"></p><ul><li>The user can select confirmation of instrument performance indicators as per JIS K 0115 General rules for molecular absorptiometric analysis, as well as the general test methods in the Japanese Pharmacopeia. (Order inspection jigs and reagents separately.)</li></ul><p><i>Note: Optional validation software is required to support the US Pharmacopeia and European Pharmacopeia.</i></p><p><strong>Support for FDA 21 CFR Part 11, PIC/S GMP Guidelines and Other Regulations and Guidelines</strong></p><p>Ensuring the integrity of data (database management), including the user management, user authority management, and data audit trails required for compliance with <strong>FDA 21 CFR Part 11, PIC/S GMP guidelines</strong>, and <strong>other ER/ES regulations</strong> is possible.</p><p><strong>Option Software Assists with Regulation-Compliant Validation</strong></p><p>UV validation software assists with performing the measurements and calculations required for validation. The software is included standard with UV-2600i/2700i models. In addition to routine inspections, it can also be used to perform instrument validation that is compliant with Japanese, US, and European pharmacopoeias.</p><p><strong>Assist Function</strong></p><p>The instrument assists the user to ensure that measurements are performed using the correct procedure.*1</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_1900i_Plus_UV_VIS_spectrophotometer_10_a30e63a8a4.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_1900i_Plus_UV_VIS_spectrophotometer_10_a30e63a8a4.jpg 245w," sizes="100vw" width="1201" height="212"></p><p>*1 This function can be enabled/disabled.</p><p><strong>Shutdown/Wakeup Functions</strong></p><section><div><p>The instrument can be shut down, and put into sleep mode. Putting the instrument into sleep mode limits power consumption and helps preserve the lamp. After a long period of measurements, the instrument and software can automatically be shut down. After shutdown, the instrument can also be set to wake up automatically at a specified time. With this function, analysis can start the instant the user arrives at the laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_15_45b844fcc9.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_15_45b844fcc9.jpg 245w," sizes="100vw" width="781" height="258"></p></div></section><h3><strong>Applications</strong></h3><h4><strong>Electricity, Electronics, and Optics</strong></h4><p><strong>Band Gap Measurements for Compound Semiconductors</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_3_03d8793fe0.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: The diffuse reflection spectra for two types of compound semiconductors (red line: Culn0.5Ga0.5Se2, blue line: CulnSe2) used as solar cell materials were measured using the ISR-2600Plus integrating sphere. It is evident that the absorption edge (position where the reflectance drops) differs depending on the sample. This difference signifies a difference in the band gap* for these samples. (The samples were provided by Wada Laboratory, Faculty of Science and Technology, Ryukoku University.) The band gaps for the samples were calculated utilizing the Tauc method. The results obtained were 1.27 eV for Culn0.5Ga0.5Se2 (red line) and 0.99 eV for CulnSe2 (blue line).  *The term band gap refers to the energy difference between the top of the valence band, which is full of electrons, and the bottom of the conduction band, which does not contain electrons." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_3_03d8793fe0.jpg 222w," sizes="100vw" width="519" height="364"></p><h4><strong>Chemicals</strong></h4><p><strong>Thickness Measurements of Cling Films</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_4_a5e83ed3ad.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: Undulating interference waveforms sometimes occur if light is passed through a film. The film thickness of a sample can be determined by using these interference waveforms. The figure shows transmittance data for a cling film. A clear interference waveform is produced. Utilizing optional film thickness measurement software, the film thickness is calculated as 10.4 μm. (Caution) The sample's refractive index must be entered for the film thickness calculation." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_4_a5e83ed3ad.jpg 222w," sizes="100vw" width="1038" height="728"></p><h4><strong>Medicines</strong></h4><p><strong>Evaluating Thermal Stability (T<sub>m</sub>) Analysis of Oligonucleotide Therapeutics</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_5_c80d107f38.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: Oligonucleotide therapeutics samples (9 to 60 M) were analyzed using TMSPC™-8i and 1 mm optical path length cells. Since UV-2600i Plus /2700i Plus can measure over a wide dynamic range, it is possible to perform a thermal stability analysis of nucleic acid drugs by obtaining the Tm value from the melting curve." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_5_c80d107f38.jpg 222w," sizes="100vw" width="1038" height="728"></p><h4><strong>Construction</strong></h4><p><strong>Window Glass Transmission Measurements</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_6_41420fd6ba.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: Two types of window glass were measured utilizing the ISR-2600Plus integrating sphere. The sample shown by the red line is highly transparent to near-infrared light at 800 nm or more. The sample shown by the blue line, however, is apparently not very transparent to near-infrared light." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_6_41420fd6ba.jpg 222w," sizes="100vw" width="519" height="364"></p><h4><strong>Cosmetics</strong></h4><p><strong>Measurement of the Ultra Violet Protection Factor Assigned to Ultraviolet Protection Clothes</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_7_528f748880.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: The UV protection provided by clothes and an umbrella were analyzed by an ISR-2600Plus integrating sphere accessory. The transmittance spectrum of the umbrella (green) shows that very little UV radiation transmits through the umbrella. In regards to the clothing, the black areas block more UV radiation than do the white areas." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_7_528f748880.jpg 159w," sizes="100vw" width="474" height="465"></p><h4><strong>Textiles</strong></h4><p><strong>Total Transmittance Spectrum of CNF</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_8_adb8c09844.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: An ISR-2600Plus integrating sphere was used to measure the total transmittance spectrum of cellulose nanofiber (CNF). Depending on the raw materials used, spectra can vary, transparency can vary, and spectral tendencies in the ultraviolet region can vary." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_8_adb8c09844.jpg 222w," sizes="100vw" width="519" height="364"></p><h4><strong>Life Sciences</strong></h4><p><strong>DNA and Protein Measurements</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_9_40a6f16a7b.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: The red and blue lines are the absorption spectra for dsDNA and BSA (bovine serum albumin), respectively. The concentration values are 45 ng/μL for dsDNA and 2.2 mg/mL for BSA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_9_40a6f16a7b.jpg 222w," sizes="100vw" width="519" height="364"></p><h4><strong>Foods</strong></h4><p><strong>Vitamin Measurements</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_10_c7f5e10b1e.jpg" alt="Shimadzu UV-2600i Plus, UV-2700i Plus UV-VIS-NIR Spectrophotometer: This shows the absorption spectra for riboflavin (vitamin B2). The sample concentrations are, in order from the highest absorbance, 0.08, 0.04, 0.02, and 0.01 mg/mL." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_UV_2600i_Plus_UV_2700i_Plus_UV_VIS_NIR_Spectrophotometer_10_c7f5e10b1e.jpg 222w," sizes="100vw" width="1038" height="728"></p></div></div></section></section></section>

Products focused on UV–VIS spectrophotometry - page 1

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