<p><strong>Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that have been widely used since the 1940s in industries and consumer goods. They are found in products like water-repellent clothing, stain-resistant fabrics, cosmetics, firefighting foams, and grease-, water-, and oil-resistant items. For instance, PFAS are commonly present in non-stick cookware used in everyday life. Their persistence and long biological half-lives have resulted in measurable levels in nearly all people in developed countries, with associated PFAS human health effects reported worldwide.</strong></p><p>Evaluating PFAS health risks requires understanding their adverse health effects at real-world exposures, particularly during sensitive life stages, along with their modes of action, toxicokinetics, and dose-response relationships. This knowledge supports risk estimates that guide public health limits, exposure reduction, and environmental cleanup efforts.</p><h3><strong>Why are PFAS a Health Concern?</strong></h3><p>PFAS have a chemical structure with a perfluorinated carbon tail that repels both water and oil and an anionic head group that attracts water, making them highly resistant and persistent. As a result, they do not break down and instead accumulate in the bodies of people and animals worldwide through food and repeated exposures. They even bio-magnify through the food web. Growing evidence has raised concerns about the harmful effects of PFAS on human health.</p><p>In the human body, PFAS bind strongly to proteins due to their polar, hydrophobic nature and have been detected in serum, cord blood, and breast milk. Unlike many other bio-accumulative contaminants, they do not tend to accumulate in fat tissue.</p><h3><strong>PFAS Testing Techniques</strong></h3><p>PFAS have a chemical structure with a perfluorinated carbon tail that repels both water and oil and an anionic head group that attracts water, making them highly resistant and persistent. As a result, they do not break down and instead accumulate in the bodies of people and animals worldwide through food and repeated exposures. They even bio-magnify through the food web. Growing evidence has raised concerns about the harmful effects of PFAS on human health.</p><p>In the human body, PFAS bind strongly to proteins due to their polar, hydrophobic nature and have been detected in serum, cord blood, and breast milk. Unlike many other bio-accumulative contaminants, they do not tend to accumulate in fat tissue.</p><p>While animal studies show that most PFAS are primarily excreted through urine, renal clearance in humans is much slower, raising significant concerns for PFAS human health. The slow elimination contributes to the long-term effects of PFAS on humans.</p><p>PFAS have extended half-lives, with perfluorooctanoic acid (PFOA) persisting for approximately 3.5 years and perfluorooctane sulfonic acid (PFOS) for roughly 4.8 years. Some studies also report a range of 2.3 to 3.3 years. These findings highlight serious PFAS health risks, demanding the need for continued monitoring and risk assessment.</p><h3><strong>Known and Suspected Health Effects of PFAs in Humans</strong></h3><h4><strong>Immunological effects</strong></h4><p>Epidemiological studies have shown that PFAS exposure is linked to weakened immune responses, including reduced antibody levels after vaccinations such as diphtheria, tetanus, rubella, and mumps, with these effects persisting into adolescence and adulthood.</p><p>Prenatal and early-life exposure to PFAS has been linked to higher risks of infections such as airway, throat, and gastrointestinal illnesses, as well as conditions like atopic dermatitis. Overall, the evidence on PFAS and human health suggests that exposure to PFAS during infancy and childhood can suppress the immune system, though some effects may differ by sex.</p><h4><strong>Liver disease and cancer</strong></h4><p>The liver is a major site for long-chain PFAS accumulation, with experimental studies showing toxic effects such as fat infiltration in liver cells, apoptosis, disrupted fatty acid metabolism, and even tumor development. Animal toxicology and histology studies indicate that PFAS can alter liver metabolism, causing increased bile acid reuptake and lipid buildup. These findings demonstrate the effects of PFAS on liver function and long-term disease risk.</p><h4><strong>Kidney diseases</strong></h4><p>PFAS exposure has been consistently linked to higher uric acid levels, a biomarker of increased risk for kidney disease, in both adults and children. The prolonged half-lives of long-chain PFAS are largely due to strong kidney reabsorption. Human studies link legacy PFAS such as PFOA and PFOS exposure to reduced kidney function and chronic kidney disease. PFOA and PFOS health effects can also be seen in the body where these substances tend to accumulate in kidney tissues causing nephrotoxicity.</p><h4><strong>Reproductive outcomes</strong></h4><p>Exposure to PFOA has been linked to reduced sperm motility, lower sperm concentration and count, and hormonal changes in young men. PFAS can also cross the placenta and accumulate in breast milk, allowing transfer from mother to child. As a result, young children often have higher serum PFAS levels than their mothers.</p><h3><strong>How do PFAS enter the Environment and Food Chain?</strong></h3><p>Human exposure to PFAS occurs through multiple pathways. These may vary from exposure to indoor air and dust to ingestion of contaminated water and food, particularly in areas near industrial sites. Thus, PFAS human health concerns may arise from:</p><ul><li><strong>Water:</strong> PFAS contaminate public and private drinking water sources, rivers, and groundwater near industrial areas, landfills, and waste sites. Firefighting foams (AFFFs) used at airports, military bases, and training facilities are a major contributor, raising concerns about PFAS chemicals health effects on the communities dependent on these resources.</li><li><strong>Soil and Air: </strong>They spread through soil and air around hazardous waste sites, manufacturing facilities such as chrome plating, electronics, textiles, paper, and through biosolids used as fertilizers.</li><li><strong>Food:</strong> PFAS enter the food chain through contaminated fish, seafood, dairy, meat, crops, and animal products. Food packaging such as grease-resistant paper, fast-food wrappers, and microwave popcorn bags also contribute PFAS to the environment.</li><li><strong>Household and Consumer Products:</strong> Everyday items like stain- and water-resistant fabrics, non-stick cookware, cleaning agents, paints, sealants, and certain personal care products (shampoo, dental floss, cosmetics) release PFAS into homes.</li><li><strong>Exposure Pathways: </strong>This is an area of growing research, it is currently understood that people are being exposed to PFAS through various means, including drinking contaminated water, eating contaminated food, inhaling polluted air or dust, swallowing soil, using PFAS-containing products, or working in high-risk occupations such as firefighting and chemical manufacturing.</li></ul><h3><strong>Importance of Accurate PFAS Testing</strong></h3><p>Accurate<a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/industries/pfas"><strong> PFAS testing solutions</strong></a> are essential to measure the presence of environmental chemicals and metabolites in human tissues and fluids. Testing can provide a clearer picture of total internal exposure from all sources and pathways. The wide diversity of PFAS, with varying chemical and physical properties, requires the development of tailored analytical procedures that depend on the sample type and medium.</p><p>The choice of biological sample depends on the specific PFAS of concern, with serum most often used to measure those with long half-lives, while urine or whole blood may be better for short-lived compounds. PFAS can also be detected in plasma, breast milk, and hair, each providing unique insights into exposure at different life stages. For example, hair can reflect historical exposures, and breast milk testing helps estimate infants intake, which is a significant concern for many communities that have been exposed to these substances.</p><p>Because PFAS detection limits are 1,000 times lower (ppt) than routine analyses (ppb), strict precautions such as verifying PFAS-free supplies are essential to prevent sample contamination, which can still occur from vendor or manufacturing changes. Extremely low detection limits and regulatory criteria is in the parts per trillion (ppt) range. Hence, field QC sample collection and analysis are crucial in investigating the effects of PFAS on humans.</p>

Health Risks Associated with PFAS Exposure

<div><div><p><strong>Scientists from UCT Prague contributed to a large-scale study showing that a small change in the so-called anticodon stem of transfer RNAs can expand their decoding capabilities – not only in eukaryotes but also in bacteria.</strong></p></div><div><p>Scientists from UCT Prague contributed to a large-scale study showing that even a small change in transfer RNA (tRNA) can fundamentally affect how a cell reads its genetic information. Computer simulations explained why certain tRNAs are able to ignore a signal that under normal circumstances marks the end of protein synthesis. Such tRNAs were previously known in higher organisms. The study, however, mapped how common these unusual tRNAs are in bacteria.</p><p>The genetic code is a&nbsp;set of rules by which cells translate genetic information during protein synthesis. Transfer RNAs (tRNAs) play a&nbsp;key role in this process, recognising short stretches of mRNA known as codons through their anticodon. In addition to amino acid codons, there is one start codon and several termination (stop) codons. Stop codons are not recognised by transfer RNAs but by specialised enzymes that terminate protein synthesis. Standard tRNAs have five nucleobase pairs in their so-called anticodon stem. Recently, however, it has emerged that some organisms carry functional tRNAs with only four pairs. These "shortened" variants can recognise even codons that, according to the classical rules, should not correspond to them.</p><p>An international team led by the <strong>Biology Centre of the Czech Academy of Sciences in České Budějovice</strong> analysed over <strong>42,000&nbsp;</strong>bacterial genomes and found that tRNAs with a&nbsp;four-pair stem occur in bacteria surprisingly often. In some cases, these variants likely enable the reading of the stop codon UGA as the amino acid tryptophan, a&nbsp;phenomenon previously associated mainly with unicellular eukaryotes.</p><p>The<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://kolar.vscht.cz/"><strong>Kolář group</strong></a><strong> </strong>at the <strong>Department of Physical Chemistry, UCT Prague</strong>, focused on the question of why a&nbsp;four-pair stem alters the decoding properties of tRNA. To address this, they employed atomistic molecular dynamics simulations, which make it possible to track the movement of every atom in a&nbsp;tRNA molecule over time.</p><p><strong>Jakub Žváček</strong>, a&nbsp;student on the Master's&nbsp;programme in Data Engineering in Chemistry, prepared a&nbsp;total of nine variants derived from the tryptophan tRNA of the bacterium Escherichia coli: the wild type with a&nbsp;five-pair stem, six mutants with a&nbsp;disrupted top base pair, and two previously described variants that promote reading of the stop codon UGA (the G24A&nbsp;and A9C&nbsp;mutations). The simulation results showed that disrupting the top base pair does not cause the overall three-dimensional structure of the tRNA to collapse. It remains stabilised by stacking interactions of neighbouring bases and non-canonical hydrogen bonds. The key finding, however, concerns a&nbsp;region at the interface of the D-arm and the stem – kind of hinge within the tRNA. In some mutants, the simulations revealed destabilisation of this region and increased flexibility of the anticodon stem, reminiscent of the behaviour of known mutations that promote stop codon readthrough. The simulations thus provided a&nbsp;structural explanation for the experimental observations and helped formulate predictions about which nucleotide combinations in the disrupted pair are functionally relevant.</p><p>The study proposed an extension of the so-called superwobble hypothesis to include non-canonical C:A&nbsp;pairing at the third codon position. If this hypothesis is confirmed for other types of tRNA as well, it will have profound implications for our understanding of how the genetic code — shared by all known organisms — has been shaped by evolution.</p><p>The results were published in the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/7/gkag327/8659125"><strong>Nucleic Acids Research</strong></a> (2026, 54, gkag327).</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_Pocitacove_simulace_osvetlily_jak_neobvykle_t_RNA_meni_pravidla_cteni_genetickeho_kodu_f6de6700a0.jpg" alt="VŠCHT Prague: Computer simulations shed light on how unusual tRNAs change the rules of reading the genetic code: Molecular architecture of the transfer RNA with the 5th anticodon-stem base pair labelled. This base pair affects the decoding ability of the tRNA anticodon." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_Pocitacove_simulace_osvetlily_jak_neobvykle_t_RNA_meni_pravidla_cteni_genetickeho_kodu_f6de6700a0.jpg 245w," sizes="100vw" width="759" height="268"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_Pocitacove_simulace_osvetlily_jak_neobvykle_t_RNA_meni_pravidla_cteni_genetickeho_kodu_2_c4296b9015.jpg" alt="VŠCHT Prague: Computer simulations shed light on how unusual tRNAs change the rules of reading the genetic code: Analysis of anticodon stem flexibility showed that the mutation of the 5th nucleobase pair (C27A), which enables stop-codon readthrough, loosens the anticodon stem in a manner similar to the previously known Hirsh mutation G24A. Conversely, the C27U mutation does not loosen the stem, which correlates with the absence of this mutation in the genomes of bacteria containing tRNAs with 4bp stems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_Pocitacove_simulace_osvetlily_jak_neobvykle_t_RNA_meni_pravidla_cteni_genetickeho_kodu_2_c4296b9015.jpg 245w," sizes="100vw" width="759" height="196"></p><blockquote><h4><strong>Original article&nbsp;</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/7/gkag327/8659125?login=false"><strong>Frequent occurrence and predicted functions of tRNAs with 4-base-pair anticodon stems in bacteria: extended superwobble hypothesis</strong></a></h4><p>Fadel Fakih, Satish Nandipati, Ambar Kachale, Jiří Heller, Jakub Žváček, Filip Brázdovič, Nawal Al-Chamy, Pragya Tripathi, Zdeněk Paris, Leoš Shivaya Valášek, Michal H Kolář, Vyacheslav Yurchenko, Marek Eliáš, Eugene V Koonin, Julius Lukeš, Anzhelika Butenko</p><p><i>Nucleic Acids Research</i>, Volume 54, Issue 7, 24 April 2026, gkag327</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1093/nar/gkag327">https://doi.org/10.1093/nar/gkag327</a></p><h6>licenced by <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Recently, a tRNA<sup>Trp</sup><sub>CCA</sub> with a 4-base-pair (bp) anticodon stem (AS) was shown to efficiently recognize a near-cognate UGA codon in unicellular eukaryotes, such as some trypanosomatids and ciliates, thereby representing a novel codon reassignment mechanism. To determine whether this mechanism also evolved in bacteria, we analysed a dataset of 42 109 genomes, including previously reported cases of stop-to-tryptophan UGA reassignment and a newly identified instance in the phylum Patescibacteriota. We show that the 4-bp AS tRNA<sup>Trp</sup> species are present across diverse bacteria and in some cases likely function in decoding in-frame UGA codons. Most notable is the endosymbiotic bacterium <i>Candidatus</i> Zinderia insecticola, which contains only the near-cognate 4-bp AS tRNA<sup>Trp</sup><sub>CCA</sub>, while lacking both canonical 5-bp AS tRNA<sup>Trp</sup><sub>CCA</sub> and a tRNA<sup>Trp</sup><sub>UCA</sub>. The secondary structure of this 4-bp AS tRNA<sup>Trp</sup> resembles that of its eukaryotic counterpart, suggesting convergent evolution. We experimentally confirmed the UGA readthrough capacity of 4-bp AS tRNA<sup>Trp</sup><sub>CCA</sub> in <i>Escherichia coli</i>, and applied molecular dynamics simulations to suggest the underlying mechanism. Furthermore, we tested several predictions based on accepting the previously excluded possibility of C:A base pairing at the 3rd codon position. These findings provide new insights into the structural diversity of transfer RNAs (tRNAs) and expand our understanding of genetic code evolution.</p></div>

Computer simulations shed light on how unusual tRNAs change the rules of reading the genetic code

<p><strong>Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity</strong></a><strong> 10.2 highlights</strong></h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4><strong>Instrument control modules</strong></h4><p>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"></p><h4><strong>MS data import/export improvements</strong></h4><p>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"></p><h4><strong>Obsolete hardware support terminated</strong></h4><p>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"></p><blockquote><p><strong>Explore the complete list of all changes, fixes, and additions in version 10.2.</strong></p><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1"><strong>See the complete changelog&nbsp;</strong></a></p></blockquote>

Clarity Chromatography Software 10.2 released!

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

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The University of Chemistry and Technology, Prague is a natural centre of first-rate study and research in the area of chemistry in Czechia and is one of the country's largest educational and research institutions focused on technical chemistry, chemical and biochemical technologies, material and chemical engineering, food chemistry, and environmental studies.

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Waters ACQUITY PREMIER UPLC System

Get the highest limits of detection, more consistent results, and better recovery, so you can see what you couldn’t before.

<p class="cke-user_style-important"><strong>Redefining separation science. Again.</strong></p><p data-pm-slice="1 3 []"><strong>The most significant innovation in separation science since we introduced UPLC™ in 2004, the ACQUITY™ Premier Solution reduces variability associated with metal-sensitive analytes - without time-consuming tasks like system and column passivation. By giving you greater confidence in your results, minimizing your risk, and increasing efficiency, you will have more time to generate meaningful data and focus on your next scientific breakthrough.</strong></p><h5><strong>With the ACQUITY Premier Solution you can:</strong></h5><ul data-spread="false"><li>Increase confidence in every result</li><li>Minimize risk of undetected analytes</li><li>Get to the right answer – faster</li></ul><h3><span><strong>Stop looking and start seeing</strong></span></h3><p data-pm-slice="1 3 []"><span>The ACQUITY Premier Solution enables your lab to make informed decisions and reduce risk with stronger analytical capabilities to detect more of your sample components from the very beginning. 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The process of obtaining these spectra is often confounded by spectral overlap from closely eluting analytes or poor-quality MS signal due to low peak concentration. MaxPeak HPS Technology eliminates secondary interactions from metals, reducing chromatographic peak tailing. The result is more gaussian peaks, reduced chromatographic coelution, and superior spectral quality.</span></p><figure class="image"><img style="aspect-ratio:1291/1172;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg" alt="Waters ACQUITY PREMIER Solution: Improve spectral quality and analyte identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg 171w," sizes="100vw" width="1291" height="1172"></figure><h3><span><strong>Global Services: Committed to your success</strong></span></h3><p data-pm-slice="1 1 []"><span>As part of the ACQUITY Premier experience, one of our applications specialists will work with you to ensure you are getting everything you need from your system. 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Waters ACQUITY UPLC H-Class PLUS System

Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution.

<div><div><h4><strong>Performance that advances your lab</strong></h4></div></div><div><div><p><strong>Whether your goal is to rapidly develop new methods or to routinely analyze large numbers of incoming samples, the ACQUITY UPLC H-Class PLUS System can help you decrease the time to result, while increasing the depth and quality of information received from your sample analysis.</strong></p><p>With the ACQUITY UPLC H-Class PLUS System, you can improve laboratory productivity by transitioning methods to UPLC/UHPLC technology, improve the characterization of your most complex samples through enhanced resolution and leverage advanced tools to simplify and streamline your method development workflow.</p><div><div><div><div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution. The system provides on-demand solvent blending and support for any analytical LC column, making it an ideal choice for modernizing existing or developing new methods." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div><ul><li><strong>Get the flexibility of multi-solvent blending</strong> - Blend up to nine solvents with integrated solvent-select valve with the Quaternary Solvent Manager&nbsp;</li><li><strong>Deliver precise and accurate binary solvent blending</strong> - Blend up to four solvents with integrated solvent-select valve with the Binary Solvent Manager</li><li><strong>Get high-precision injections with direct inject sampling&nbsp;</strong>- The needle-in-flow path design ensures an accurate needle seal at high pressure</li><li><strong>Get accurate temperature control across the entire column</strong> - Configurable for 1 to 6 columns with active preheating</li><li><strong>Automate the formulation of mobile phases</strong> - Significantly reduce the time you spend in the prep lab with&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"> Auto•Blend Plus </a>Technology</li><li><strong>Transfer methods more easily</strong> - Easily adjust for system volume differences when transferring methods from an alternative LC system without alteration to the method table using Gradient SmartStart </li><li><strong>Wide software support</strong> – ACQUITY UPLC H-Class PLUS System is supported by  <strong>Empower, MassLynx, UNIFI</strong>, and several 3rd party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Improving laboratory productivity by transitioning methods to UPLC technology.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: A highly reliable and robust LC-MS system without any compromise in speed, resolution, or sensitivity, especially in everyday settings. The ACQUITY H-Class PLUS Binary System combines an optimized flow path resistant to clogging, stable high-pressure gradient formation, and support for sub-2-µm to 5-µm particle columns to deliver the ideal choice for reproducible everyday LC-MS analyses with any tandem quad or Q-ToF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div><div><div><h3><strong>Discover the UPLC difference</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS System</strong> is the next evolution of ultra-performance instrumentation, providing the <strong>high resolution</strong> of a <strong>quaternary or binary liquid chromatography (LC) system</strong>.</p><p>Achieving <strong>true UPLC performance</strong> requires that system dispersion (or extra-column band spread) be matched to the peak widths associated with narrow bore columns packed with <strong>sub-2-μm particles</strong>. While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the <strong>sharp peaks of UPLC performance</strong> and the <strong>ACQUITY UPLC H-Class PLUS System</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Comparison of the same method with the same column on a low-dispersion ACQUITY UPLC H-Class PLUS System versus a higher-dispersion UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg 245w," sizes="100vw" width="1024" height="555"></p></div></div><div><div><h3><strong>Take your methods to the next level</strong></h3><p>Leverage the benefits of <strong>UPLC technology</strong> to improve your existing <strong>HPLC methods</strong>. By scaling your methods to UPLC, your laboratory will benefit from the combination of <strong>increased resolution, sensitivity, and speed</strong> that comes with modern small particle chemistries.</p><p>Designed to accommodate all of your LC method needs, the <strong>ACQUITY UPLC H-Class PLUS System</strong> is ideally suited to <strong>future-proof your laboratory</strong>, enabling the support of existing HPLC methods now, and provide <strong>significant productivity and cost benefit</strong> when utilized for UPLC methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: The USP analysis of diclazuril and organic impurities was scaled from HPLC to UHPLC to UPLC. The UPLC method resulted in a 4x reduction in run time and a 10x reduction in solvent consumption resulting in improved sample throughput and reduced cost per analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg 245w," sizes="100vw" width="1024" height="613"></p></div></div><div><div><h3><strong>Discover the best method for the best results</strong></h3><p>Get the <strong>versatility</strong> to discover the best set of chromatographic conditions for your sample, providing a <strong>more robust method</strong>. The flexibility of the <strong>ACQUITY UPLC H-Class PLUS Quaternary System</strong> allows you to <strong>automatically screen important method parameters</strong>, including:</p><ul><li>Up to <strong>six columns</strong> in independently temperature-controlled compartments</li><li>pH and ionic strength with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"><strong>Auto•Blend Plus</strong></a><strong> Technology</strong></li><li><strong>Optional and integrated solvent selection valve</strong> expands access to six additional mobile phase lines&nbsp;</li><li><strong>11 unique gradient profiles</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: (A) Auto·Blend Plus method gradient table for trastuzumab pH optimization. (B) pH optimization on trastuzumab charge variants separation. Gradient: 20 mM MES buffer, 50–155 mM NaCl in 15 min." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg 245w," sizes="100vw" width="1024" height="622"></p></div></div><div><div><h3><strong>Deliver greater speed and precision for routine analyses</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> combines the <strong>proven reliability and performance</strong> of the H-Class PLUS System with the <strong>precision and lowest system volume</strong> offered by our <strong>high-pressure mixing binary solvent manager</strong>, allowing you to:</p><ul><li>Accommodate the <strong>most challenging sample matrices</strong></li><li>Tackle applications with <strong>long shallow gradients</strong></li><li><strong>Improve the throughput</strong> of your methods</li></ul><p><strong>Combine </strong>the capabilities of the <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> with <strong>Waters </strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Tandem-Quadrupole-%28-Triple-Quadrupole-%29-Mass-Spectrometry/nav.htm?cid=134656172"><strong>Tandem quadruple technology</strong></a><strong> </strong>for routine quantitative UPLC-MS/MS applications, so you can confidently quantify and trace components in the most complex of samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Direct transfer without a gradient delay offers the opportunity for method improvement with the analysis time going from 5 minutes to 3 minutes representing a 40% reduction in runtime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg 245w," sizes="100vw" width="1024" height="600"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 15,000 psi</li><li><strong>pH range</strong>: 1–12.5 (<i><span>For specific test conditions, contact your Waters sales representative)</span></i></li><li><strong>Operating flow rate range</strong>: Up to 2.2 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: ≤0.002% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary, Quaternary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 6 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications</strong> <strong>(QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div></div></div></div></div>

Waters ACQUITY UPLC I-Class PLUS System

With the ACQUITY UPLC I-Class PLUS System, your lab can achieve highly efficient, rapid separations from ultra-low dispersion and delay volume.

<div><div><h4><strong>Complex chromatography challenges, solved</strong></h4></div></div><div><div><p><strong>Looking for answers to the most complex scientific challenges is what you do, and the scientific tools you deploy and the information they provide can make all the difference. With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS System provides new possibilities for maximizing the resolution and sensitivity of your methods, enhancing the characterization of your samples, and improving productivity to advance the science of your laboratory.</strong></p><div><div><div><div><p>With the <strong>ACQUITY UPLC I-Class PLUS System</strong>, your lab can achieve <strong>highly efficient, rapid separations</strong> from <strong>ultra-low dispersion and delay volume</strong>. The system enables your lab to get <strong>narrow, ultra-efficient peaks</strong>, enhancing the <strong>sensitivity of any mass spectrometer</strong> and simplifying the characterization of the most complex sample.</p><ul><li><strong>Achieve precise and accurate binary solvent blending</strong> with the Binary Solvent Manager, ideal for up to four solvents with integrated solvent-select valve</li><li><strong>Get sample injection versatility</strong>, depending upon your application with the flow-through needle and fixed loop injector options</li><li><strong>Manage ultra-low carryover</strong> through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers</li><li><strong>Get accurate temperature control</strong> across the entire column, configurable for 1 to 2 columns with active preheating</li><li><strong>Improve the performance of any mass spectrometer</strong> with the highest chromatographic resolution which minimizes interference from co-elutions</li><li><strong>Minimize the time and cost</strong> associated with annual qualification with the Waters Empower-based automated system qualification tool (SQT)</li><li><strong>Supported by Empower, Masslynx, UNIFI</strong>, and several third-party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p><strong>Enhance the characterization of your samples</strong>, while <strong>improving productivity</strong> to advance the science of your laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: ACQUITY UPLC I-Class PLUS System FTN-H PDA angled." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg 245w," sizes="100vw" width="1024" height="637"></p><div><div><div><div><h3><strong>Get a clearer picture of your sample</strong></h3><p>Get improved resolution through <strong>reduced system dispersion</strong> with the <strong>ACQUITY UPLC I-Class PLUS System</strong>, providing separations that can amplify your research.</p><p><strong>Shorten analysis times</strong>, <strong>reduce solvent usage</strong>, and <strong>speed access to the data</strong> you need for critical decisions. Designed to fit into your existing LC workflow, the ACQUITY UPLC I-Class PLUS System provides a <strong>clear view into what lies within the sample</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg 245w," sizes="100vw" width="1024" height="595"></p></div></div></div></div></div></div></div></div><div><div><h3><strong>An inlet that improves the performance of any MS</strong></h3><p>The ACQUITY UPLC I-Class PLUS System is designed specifically for the <strong>rapid pace of laboratories</strong> on the <strong>cutting edge of research</strong> where <strong>LC-MS plays a critical role</strong>.</p><p><strong>With the ACQUITY UPLC I-Class PLUS System, your lab will:</strong></p><ul><li><strong>Improve resolution and ionization efficiency</strong> with narrow peak widths, enhancing <strong>mass spectrometry sensitivity</strong></li><li><strong>Enhance sensitivity</strong> through <strong>industry-leading carryover performance</strong></li><li><strong>Improve sample characterization</strong> through <strong>selective isolation</strong> with multidimensional UPLC configurations</li><li><strong>Achieve exceptionally fast analysis times</strong> with <strong>ultra-low delay volume</strong></li><li><strong>Achieve ultimate peak capacity</strong> with <strong>CORTECS Columns</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg 182w," sizes="100vw" width="1024" height="878"></p></div></div><div><div><h3><strong>Achieve ultimate peak capacity with CORTECS Columns</strong></h3><p>When paired with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/columns/cortecs-columns.html"><strong>CORTECS 1.6 µm solid-core columns</strong></a>, the ACQUITY UPLC I-Class PLUS System enables scientists to achieve new levels of resolution, sensitivity, and chromatographic performance. With <strong>CORTECS Columns</strong> and the ACQUITY UPLC I-Class PLUS System, you can increase resolution for even your toughest samples and get the flexibility and power you need to rapidly separate a wide array of compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg 210w," sizes="100vw" width="1024" height="761"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 18,000 psi</li><li><strong>pH Range</strong>*: 1–12.5</li><li><strong>Operating flow rate range</strong>: Up to 2.0 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: &lt;0.001% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 2 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications (QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div>

Waters ACQUITY Arc LC System

The ACQUITY™ Arc™ System is an all-in-one platform for HPLC and UHPLC, designed for robust method development and seamless transfer between modern LC systems, addressing a wide range of analytical challenges.

<p class="cke-user_style-important"><strong>Built upon a foundation of reliability</strong></p><p data-pm-slice="1 1 []"><strong>The method development process is changing. New regulations, software and analytical technologies are rapidly changing how methods are designed, transferred, and monitored over their lifecycle. An all-in-one platform for HPLC and UHPLC separations, the ACQUITY™ Arc™ System is designed to meet the spectrum of challenges you face from robust method development to seamless transfer between any modern LC systems.</strong></p><p data-pm-slice="1 1 []">With the <strong>ACQUITY Arc System</strong>, you can experience true plug-and-play method compatibility for HPLC and UHPLC separations. Significant productivity gains can be realized by deploying a single LC platform that allows for the efficient transfer, adjustment, and improvement of methods from any LC platform without compromise in method integrity.</p><figure class="image"><img style="aspect-ratio:768/886;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_63246061ea.jpg" alt="Waters ACQUITY Arc System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_63246061ea.jpg 136w," sizes="100vw" width="768" height="886"></figure><p data-pm-slice="1 1 []">Laboratory-driven organizations have relied on Waters for over 60 years to deliver reliable, robust, and reproducible solutions to ensure confidence in their analytical results. With over 100,000 LC systems installed, we understand the significant impact the right technology has on your business, and the implications it has on characterizing the quality and safety of your products.</p><p data-pm-slice="1 1 []">Methods with greater agility, robustness, and capacity for change can help you reduce regulatory burden, risk of failure and costs. Visit <a disabled="true">www.methods.waters.com</a> to learn more about how method life cycle management (MLCM) connects your method today to your method tomorrow.</p><h3><strong>Designed for discovery to routine QC applications</strong></h3><p>The <strong>ACQUITY Arc System</strong> is the only available LC system with regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument. With unrivaled column capacity and Arc Multi-flow path™ technology, the<strong> ACQUITY Arc System</strong> allows you to generate new methods and modernize legacy HPLC methods faster than ever before.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Comprehensive detector portfolio</strong></h4><p>High-performance analytical detectors designed to maximize HPLC and UHPLC performance, delivering exceptional sensitivity and linearity for your assays.</p><p>Photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, and mass detection, including the ACQUITY QDa™ Detector.</p><h4><strong>Gradient SmartStart</strong></h4><p>Automatically manage gradient start time and pre-injection steps to maximize sample throughput. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.</p><h4><strong>Quaternary solvent management</strong></h4><p>Precise and accurate blending of up to four solvents with automated solvent compressibility compensation. Increase solvent flexibility with an optional, integrated solvent select valve, providing access to six additional solvents.</p><h4><strong>Negligible carryover</strong></h4><p>Advanced flow-through needle design minimizes carryover by continuously cleansing the needle during run. User-configurable wash settings provide flexibility to address even the most complex sample matrices.</p><h4><strong>Thermal management options</strong></h4><p>Column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm, with a temperature range of 4 °C to 90 °C. Integrated column selection valve options provide unattended, fast column changeover.</p><h4><strong>Auto•Blend™ Plus Technology</strong></h4><p>Program gradients directly in terms of pH and ionic strength to minimize manual mobile phase preparation, reduce potential for human error, and accelerate method robustness testing for chromatographic methods.</p><h4><strong>Arc Multi-flow path technology</strong></h4><p>Delivers plug-and-play method compatibility with HPLC or UHPLC methods with the flip of a switch.</p><p>Easily replicate or improve established methods by simply selecting between Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention.</p><h4><strong>Column Technology</strong></h4><p>Industry-leading selectivity choices to meet the needs of virtually every LC application.</p><h4><strong>Laboratory Informatics</strong></h4><p>Software control within your existing Empower™ or MassLynx™ infrastructure.</p><h3><strong>Replicate your established methods</strong></h3><p data-pm-slice="1 1 []">The <strong>ACQUITY Arc System</strong>, enabled by unique Arc Multi-flow path technology, easily accepts and replicates methods from any HPLC platform, without compromise.&nbsp;</p><p data-pm-slice="1 1 []">Whether you are trying to replicate an out-of-date HPLC method, transfer methods across the organization, or to contract partners, the <strong>ACQUITY Arc System</strong> gives you ultimate flexibility to reproduce, modernize, and transfer existing methods with ease and greater cost efficiency, while preserving the integrity of your methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg" alt="Waters ACQUITY Arc System: Analysis run on a Vendor X LC system and replicated on the ACQUITY Arc System. Conditions: 15 to 35% B in 3 min, 35 to 95% B in 2 min; Mobile phase A: 0.1% HCOOH in H 2 O, mobile phase B: 0.1% HCOOH in ACN; Flow rate = 2.0 mL/min; Column: XSelect™ CSH C 18 , 4.6 x 150 mm, 5 μm; Temp. = 30 °C; UV@ 260 nm; 10.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg 245w," sizes="100vw" width="1099" height="596"></p><p>Upgrade your laboratory with a versatile, modern LC system that delivers HPLC and UHPLC method compatibility at the flip of a switch.</p><h3><strong>Modernize your methods</strong></h3><p>The United States Pharmacopeia (USP) is championing pharmacopeial harmonization and modernization efforts, and international organizations are following suit. As a result, the USP is encouraging the modernization of older compendial methods to ensure they are fit for purpose.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg" alt="Waters ACQUITY Arc System: Quetiapine fumarate system suitability solution analyzed on the ACQUITY Arc System using HPLC, UHPLC, and UPLC™ column/method conditions for the quetiapine impurity method. Peak identification: (1) quetiapine related compound G, (2) quetiapine related compound B, (3) quetiapine desethoxy, and (4) quetiapine." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg 245w," sizes="100vw" width="1092" height="678"></p><p>Revisions to these guidelines give you more flexibility to modify your existing pharmacopeial methods with modern techniques and technologies, and in some cases avoid revalidation. The <strong>ACQUITY Arc System</strong>, featuring the Waters Columns Calculator, allows you to confidently scale your gradient methods from a 3.5 μm to a 2.5 μm particle, decreasing run times, lowering solvent consumption, and increasing sample throughput.</p><h3><span><strong>Save time. Reduce cost.</strong></span></h3><p data-pm-slice="1 1 []">With the right column, the <strong>ACQUITY Arc System</strong> is the ideal solution to accommodate methods from any LC platform.&nbsp;</p><p data-pm-slice="1 1 []">From concept to production, the transition your product takes through the product development cycle often requires rigorous LC assays to properly characterize and assess its readiness to advance to the next stage. These LC assays are often adapted to accommodate the technology available from one stage to the next, in some cases requiring an adjustment from a smaller particle size (sub-2-μm) to a larger particle size (2.5 μm–5 μm).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System enables the support of HPLC and UHPLC methods on a single platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg 173w," sizes="100vw" width="959" height="860"></p><p>The <strong>ACQUITY Arc System</strong> provides the flexibility to maximize productivity through efficient and rapid 2.5 μm–2.7 μm UHPLC separations, or to accommodate larger 3.0 μm–5 μm HPLC particles.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg" alt="Waters ACQUITY Arc System: Save time. Reduce cost." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg 245w," sizes="100vw" width="1683" height="469"></p><h3><span><strong>Mitigate your risk</strong></span></h3><p data-pm-slice="1 1 []">With an expanded range of column manager options enabling up to 15-column switching from 4 °C to 90 °C, the <strong>ACQUITY Arc System</strong> will help you significantly reduce the time spent generating robust methods. Equipped with the plug-and-play ACQUITY QDa Mass Detector, the <strong>ACQUITY Arc System</strong> tracks peaks in your method and reveals hidden coelutions of similar analytes, ensuring you have complete confidence in the reliability and reproducibility of your method now and far into the future.</p><h4><strong>Thermal management options</strong></h4><p data-pm-slice="1 1 []">Active and passive pre-heating options available, with up to 15-column switching from 4 °C to 90 °C. Automated monitoring and tracking of column usage with eCord™ technology available with active pre-heating options.</p><h4><strong>Quaternary solvent management</strong></h4><p data-pm-slice="1 1 []">Accelerate your method development with precise and accurate blending of up to four solvents. Increase solvent flexibility with an optional solvent select valve, providing access to six additional solvents.</p><h4><strong>Auto•Blend Plus Technology</strong></h4><p data-pm-slice="1 1 []">Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</p><h4><strong>Comprehensive detector portfolio</strong></h4><p>Diverse portfolio of detectors for method development, method transfer, and routine use.</p><h4><strong>ACQUITY QDa Detector</strong></h4><p>Mass detection built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no adjustments, it easily integrates with your<strong> ACQUITY Arc System.</strong></p><h5><strong>Support</strong></h5><p data-start="0" data-end="175">Empower eLearning modules to help train your lab on Empower 3 and Method Validation. Applications support that’s customized based on your method development needs.</p><h5><strong>Consumables</strong></h5><p data-start="177" data-end="410" data-is-last-node="">Industry-leading selectivity choices to meet the needs of virtually every LC application. Quality Control (QC) Reference Material benchmarks your <strong>ACQUITY Arc System </strong>and enables perfect resolution. Certified clean vials.</p><h5><strong>Laboratory Informatics</strong></h5><p>Software control within your existing Empower or MassLynx infrastructure. Empower 3 Method Validation Manager allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</p><h3><span><strong>Develop methods that stand the test of time</strong></span></h3><p>Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.</p><p>The <strong>ACQUITY Arc System</strong> is fully compatible with the ACQUITY Arc, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram, leaving nothing to chance.</p><ul><li>Confirm the identity of peaks in a separation without injecting standards.</li><li>Identify new peaks in a separation with molecular weight information.&nbsp;</li><li>Detect unresolved peaks and determine if a peak is homogeneously pure.</li><li>Easily track peaks as method conditions are changed.</li></ul><p data-start="272" data-end="600">Using Empower 3 Software and its Custom Calculations and Custom Reporting functions enables you to quickly and automatically evaluate chromatographic data. Configurable reports allow you to choose optimal conditions based on metrics rather than judgment, ensuring a comprehensive assessment of data and best method conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_7_e7ef959203.jpg" alt="Waters ACQUITY Arc System: Method transfer of USP Assay for Fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. Conditions: Mobile phase: 20:80 acetonitrile/ water; Flow rate = 0.5 mL/min; Column: XSelect HSS T3, 4.6 x 150 mm, 3.5 μm; UV@ 260 nm; 20.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_7_e7ef959203.jpg 224w," sizes="100vw" width="939" height="654"></p><h3><strong>Streamline your workflow</strong></h3><div><div data-message-author-role="assistant" data-message-id="7b732be9-0a45-45fb-b585-70a90c1a74d6" dir="auto" data-message-model-slug="gpt-4o"><div><div><p data-start="602" data-end="827">How would you benefit from increased assay consistency between analysts and from lab to lab? What would you gain by accelerating your robustness testing prior to transferring methods to QA/QC?</p><p data-start="829" data-end="1392" data-is-last-node="">Auto•Blend Plus Technology is a novel software tool that extends traditional quaternary solvent blending to permit gradient programming directly in units of pH and ionic strength, providing the ability to vary composition in even the smallest increments of pH (even those differing by 0.1 pH units or less).&nbsp;</p><p data-start="829" data-end="1392" data-is-last-node="">With Auto•Blend Plus, the cumbersome and error-prone approach of manually preparing several pre-mixed mobile phases can now be eliminated with on-demand mobile phase creation, providing significant time savings and improved productivity to the laboratory.</p></div></div></div></div>

Products focused on HPLC - page 9

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