<p><strong>🎤Brad Haubrich </strong>(Touro University Nevada )</p><p><strong>Neglected and opportunistic infectious diseases affect some of the world’s most vulnerable populations—but often receive the least attention from traditional drug discovery pipelines.</strong></p><p>In this episode of Concentrating on Chromatography, host David Oliva sits down with Brad Haubrich to explore how early-stage drug discovery is being applied to fungal and parasitic pathogens, including those responsible for neglected tropical diseases and infections that disproportionately affect immunocompromised patients.</p><p>Brad shares how his lab approaches drug discovery when the pathogen is eukaryotic—and therefore biologically similar to humans—making selectivity one of the biggest challenges. The conversation covers:</p><ul><li>What defines neglected and opportunistic diseases—and why commercial incentives often fall short</li><li>Target-based vs. phenotypic drug discovery and when each approach makes sense</li><li>Using binding kinetics and residence time to improve selectivity and reduce off-target effects</li><li>Where chromatography, metabolomics, and mass spectrometry still play a critical role—even when not front-and-center</li><li>The growing (and realistic) role of AI in drug discovery, especially for underfunded disease areas</li><li>Why World Neglected Tropical Diseases Day (January 30) matters for raising awareness and accelerating progress</li></ul><p>This episode highlights how analytical chemistry, separation science, and biological insight intersect in the earliest stages of drug discovery—and why progress in this space depends as much on collaboration and curiosity as it does on technology.</p><h3><strong>Video Transcription</strong></h3><p>In this interview, Dr. Brad Haubrich discusses his research focus on neglected tropical diseases (NTDs) and opportunistic infections. His interest in this field originated during graduate and postdoctoral studies, particularly through work on African sleeping sickness. Neglected diseases are defined as conditions that predominantly affect populations in low- and middle-income countries, where both healthcare infrastructure and commercial incentives for drug development are limited. Similarly, opportunistic infections disproportionately impact immunocompromised individuals, including patients with cancer, transplant recipients, and those undergoing immunosuppressive therapy.</p><p>A key challenge in this area is the limited commercial interest in drug discovery, resulting in fewer therapeutic options despite significant unmet medical needs. The research emphasizes fungal and parasitic pathogens, which present distinct challenges compared to bacterial targets, particularly due to shared biological pathways between pathogens and human hosts.</p><h4><span><strong>Drug Discovery Strategies and Challenges</strong></span></h4><p>The discussion highlights two complementary approaches used in the lab: target-based and phenotypic drug discovery. Target-based strategies involve identifying and biochemically characterizing specific pathogen proteins, while phenotypic approaches assess compound activity directly in living cells. Each approach has advantages and limitations, particularly in identifying molecular targets and ensuring biological relevance.</p><p>A major scientific challenge is achieving selectivity. Because eukaryotic pathogens share many proteins with human cells, identifying compounds that selectively inhibit pathogen targets without affecting host systems is difficult. To address this, the lab incorporates <strong>binding kinetics</strong> as an early screening parameter. Instead of relying solely on traditional potency metrics, this approach evaluates how long a compound interacts with its target, enabling the identification of molecules with prolonged, selective binding (pseudo-irreversible inhibition), which may improve therapeutic specificity.</p><h4><span><strong>Role of Analytical Techniques and Chromatography</strong></span></h4><p>Although chromatography is not central to all workflows in the lab, it remains critical in several areas. It is widely used by collaborators for compound purification and plays an important role in emerging projects focused on <strong>pharmacognosy</strong>, where bioactive compounds are isolated from natural sources such as desert flora.</p><p>Chromatography, coupled with mass spectrometry, is also essential for <strong>metabolomics-based target identification</strong>. In phenotypic screening, where the molecular target is initially unknown, changes in metabolite profiles can provide insight into biochemical pathways affected by candidate compounds, supporting target deconvolution.</p><h4><span><strong>Impact, Training, and Future Directions</strong></span></h4><p>The success of research in neglected diseases is not solely measured by commercial outcomes but also by contributions to scientific knowledge and global health. Even incremental findings can support future therapeutic breakthroughs.</p><p>The interview also emphasizes the role of students, particularly in academic medical settings, where participation in early-stage drug discovery provides valuable insight into the full pipeline from molecular discovery to clinical application.</p><p>Looking ahead, <strong>artificial intelligence (AI)</strong> is identified as a key driver of innovation in drug discovery. AI tools can accelerate compound screening, predict bioactivity, and even suggest synthetic pathways. However, their effectiveness in neglected disease research is currently limited by the availability of large, high-quality datasets.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Drug Discovery Where the Market Doesn’t Go: Targeting Neglected & Opportunistic Pathogens

<p><strong>This study investigates the optimization and functional properties of kombucha enriched with </strong><i><strong>Prunus spinosa</strong></i><strong> juice and bee products (propolis, pollen, and bee bread). Advanced analytical techniques (HPLC–DAD, LC–MS/MS) revealed enhanced phenolic, amino acid, and antioxidant profiles, with bee bread enrichment showing the highest overall bioactive content and sensory acceptance.</strong></p><p>Propolis-enriched kombucha exhibited the strongest in vitro antidiabetic activity, while pollen enrichment provided the highest amino acid levels. Despite partial losses during digestion, significant retention of bioactives suggests potential postdigestive benefits. These findings highlight the potential of enriched kombucha as a functional beverage with nutraceutical value.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.6c00008"><strong>From Chemistry to Functionality: HPLC–DAD/LC–MS/MS Characterization of Bee Product-Enriched Prunus spinosa L. Kombucha with In Vitro Antidiabetic Activity and Bioaccessibility</strong></a></h4><p>Melikenur Türkol, Çiğdem Yıldırım Maviş, and Seydi Yıkmış*</p><p>ACS Omega 2026, 11, 8, 14048–14063</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acsomega.6c00008">https://doi.org/10.1021/acsomega.6c00008</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><div><p>Kombucha tea, a traditionally fermented beverage, is believed to have originated as early as 200–300 BC. In recent decades, it has attracted growing global interest due to its recognized health-promoting properties and its deep cultural roots. <a href="javascript:void(0);">(1,2)</a> Sweetened tea derived from <i>Camellia sinensis</i> is transformed into kombucha through fermentation carried out by a SCOBY (Symbiotic Culture of Bacteria and Yeast), a mixed culture of yeasts and bacteria that forms a cellulose-rich biofilm throughout the process. <a href="javascript:void(0);">(3)</a> SCOBY represents a symbiotic consortium of microorganisms that comprises various yeast genera, including <i>Saccharomyces</i>, <i>Schizosaccharomyces</i>, <i>Zygosaccharomyces</i>, <i>Brettanomyces/Dekkera</i>, and <i>Pichia</i>, as well as both acetic and lactic acid bacteria. <a href="javascript:void(0);">(2)</a> During fermentation, the sugars formed contribute a mild sweetness to the tea, whereas the organic acids synthesized by acetic acid bacteria are responsible for its distinctive sour flavor. <a href="javascript:void(0);">(4)</a> Kombucha tea is traditionally brewed using black tea; however, alternative versions can also be produced with other types of tea. <a href="javascript:void(0);">(5)</a> It has been reported that herbal infusions and fruit juices can also be used for fermentation with the kombucha culture, and due to their chemical composition, these substrates have been shown to serve as promising alternatives. <a href="javascript:void(0);">(6)</a> The antioxidant potential of kombucha tea is primarily linked to its abundant phenolics, with flavonoids playing a significant contributory role. <a href="javascript:void(0);">(7)</a> A high anthocyanin content tends to enhance the antioxidant capacity. <a href="javascript:void(0);">(8)</a> The antioxidant activity of kombucha tea can be improved by incorporating anthocyanin-rich fruits. Accordingly, the use of wild fruits with high anthocyanin content─such as <i>Prunus spinosa</i> L. (blackthorn), <i>Prunus laurocerasus</i> (cherry laurel), and <i>Rubus idaeus</i> (red raspberry)─has been considered a practical way to improve the beverage’s nutritional, functional and sensorial properties. <a href="javascript:void(0);">(9)</a></p><p>Propolis is a naturally occurring material that honeybees gather from the resins of different trees and the buds of various plants. <a href="javascript:void(0);">(28,29)</a> Propolis is a chemically complex matrix comprising more than 300 identified components, including flavonoids, phenolic acids, and their ester derivatives, and is associated with a wide range of biological activities such as antiviral, antioxidant, antimicrobial, anti-inflammatory, antitumor, hepatoprotective, and immunomodulatory effects. <a href="javascript:void(0);">(30−34)</a> Minerals and vitamins are also present in high concentrations in propolis. <a href="javascript:void(0);">(28)</a> Bee pollen is formed when bees agglutinate pollen grains using their saliva, nectar, or honey and store them in granular form in their honeycomb cells. The key role of bee pollen is to ensure the colony’s survival by providing the necessary nutrients, thereby supporting development and maintenance processes. <a href="javascript:void(0);">(35)</a> Bee pollen is a natural product rich in bioactive compounds. More than 250 bioactive compounds have been identified in bee pollen derived from different plant species. These basic chemical components include lipids, amino acids, proteins, carbohydrates, fatty acids, phenolic compounds, carotenoids, flavonoids, vitamins, and bioelements. <a href="javascript:void(0);">(36)</a> Exhibits antihyperglycemic, anti-inflammatory, hepatoprotective, nephroprotective, and anticancer properties thanks to its rich and versatile component mixture. <a href="javascript:void(0);">(37,38)</a> Many of these have demonstrated antioxidant, antimicrobial, antidiabetic. They have shown promising results in the treatment of diabetes and obesity, and their potential as natural therapeutic agents has been evaluated. They have been found to increase insulin sensitivity, reduce oxidative stress, regulate appetite, adjust obesity-related hormone levels, and strengthen antioxidant defense systems. <a href="javascript:void(0);">(39,40)</a> The antimicrobial effect of bee bread has been extensively studied. Bakour et al. found that different bacterial species and fungi are sensitive to the hydromethanolic bee bread extract. <a href="javascript:void(0);">(41)</a> A vital bee byproduct, bee bread is formed after the pollen gathered by bees is enriched with nectar and bee saliva, leading to an ensuing lactic acid fermentation process inside the hives. <a href="javascript:void(0);">(42)</a> Bee bread is high in nutrition, with significant carbohydrates, proteins and lipids. It is a rich source of vitamins, phenolic compounds, minerals and essential amino acids, and exhibits multiple chemical activities. <a href="javascript:void(0);">(43,44)</a></p><p>The Response Surface Method (RSM) is one of the statistical optimization approaches. This method uses empirical modeling techniques to identify relationships between independent variables and the system response using experimental data. It also allows for determining optimal conditions for achieving the desired outcome by evaluating the effects of process variables on the system response. <a href="javascript:void(0);">(45−47)</a></p><p>Previous studies have not extensively investigated the sensory parameters (color, taste, smell, and general acceptance) of kombucha tea enriched with <i>P. spinosa</i> L. and bee products using RSM. The primary aim of this study was to optimize the sensory properties of kombucha formulations enriched with <i>P. spinosa</i> L. and bee-derived ingredients (bee bread, propolis, and pollen) using RSM to determine the most acceptable formulation. While many studies have examined kombucha enriched with various fruit and plant infusions, none have specifically investigated the impact of <i>P. spinosa</i> L. and bee products on kombucha’s sensory and bioactive properties. The study also evaluated the total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity (DPPH•), total anthocyanin content (TAC), phenolic profile (HPLC), microbiological quality, and levels of organic acids amino acids and in vitro bioaccessibility in the developed samples, as well as their antidiabetic activity. RSM-based optimization offers a new methodological approach. It is expected to yield valuable data. This data will improve the functional and disease-fighting properties of kombucha.</p><h4><strong>2. Materials and Methods</strong></h4><h5><strong>2.9. Analysis of Phenolic Compounds (HPLC)</strong></h5><p>Chromatographic separation was carried out on an ACE Genix C18 column (250 × 4.6 mm, 5 μm; Agilent), following the procedure reported by Portu et al. (2017). <a href="javascript:void(0);">(56)</a> Phenolics were characterized using an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1260+LC"><strong>Agilent 1260 HPLC</strong></a>–DAD system operated under gradient conditions at 30 °C with a flow rate of 0.80 mL/min. The mobile phase comprised solvent A (water supplemented with 0.1% phosphoric acid) and solvent B, applied according to a predefined gradient program. Samples were injected at a volume of 10 μL, and chromatograms were recorded at 280, 320, and 360 nm. Quantitative results were reported as μg/mL.</p><h5><strong>2.10. Analysis of Organic Acids (HPLC)</strong></h5><p>HPLC was used to determine organic acid profiles, following a method adapted with minor modifications from Coelho et al. <a href="javascript:void(0);">(57)</a> Organic acids were analyzed using an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1260+LC"><strong>Agilent 1260 Infinity LC HPLC system</strong></a> fitted with refractive index (RID) and diode array (DAD) detectors. Samples were filtered through a 0.45 μm syringe filter, and a 20 μL aliquot was injected into an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1260+LC"><strong>Agilent Hi-Plex H ion-exchange column</strong></a> (300 × 7.7 mm). Chromatographic separation was carried out using 10.0 mM H<sub>2</sub>SO<sub>4</sub> as the mobile phase at a flow rate of 0.6 mL/min, with the column temperature set to 65 °C and the RID cell maintained at 35 °C. The total run time was 20 min. DAD additionally monitored tartaric, pyruvic, and acetic acids at 210 nm. Quantitative determination was carried out using external calibration standards, and the results were reported in g/L.</p><h5><strong>2.11. Determination of Free Amino Acids (LC–MS)</strong></h5><p>Amino acid composition was determined using a method adapted with minor modifications from the procedure described by Bilgin et al. (2019). <a href="javascript:void(0);">(58)</a> A gradient elution scheme involving mobile phases A and B was applied to obtain chromatographic separation at a flow rate of 0.7 mL/min, yielding a total run duration of 7.5 min. Tandem mass spectrometric analyses were performed on an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10"><strong>Agilent 6460 triple quadrupole LC–MS instrument</strong></a> (Agilent Technologies, Waldbronn, Germany) fitted with an electrospray ionization (ESI) interface. The mass spectrometer was operated with a gas temperature of 150 °C, a gas flow rate of 10 L/min, a nebulizer pressure of 40 psi, and a capillary voltage of +2000 V. All analyses were carried out in triplicate, and the results were reported as mg/100 mL.</p><h4><strong>3. Results and Discussion</strong></h4><h5><strong>3.4. Phenolic Compounds (HPLC)</strong></h5><p>As presented in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.6c00008#tbl1">Table 1</a>, the total quantified phenolic content differed significantly among the treatments (<i>p</i> &lt; 0.05). The control sample (BKT) exhibited the lowest phenolic concentration (106.35 ± 2.25 μg/mL), whereas pollen supplementation (PL-BKT) resulted in a substantial increase, reaching 159.23 ± 4.82 μg/mL. Further enhancement of the phenolic pool was achieved through propolis (PB-BKT: 178.66 ± 5.04 μg/mL) and bee bread (BB-BKT: 186.15 ± 0.97 μg/mL) supplementation. No statistically significant difference was observed between PB-BKT and BB-BKT in total quantified phenolics; however, both treatments exhibited significantly higher values than PL-BKT and the control, indicating a more pronounced phenolic enrichment.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2026_11_8_14048_14063_Table_1_Changes_in_Total_Phenolic_Compounds_of_Kombucha_Samples_Subjected_to_BKT_PB_BKT_PL_BKT_and_BB_BKT_5a50c7851f.jpg" alt="ACS Omega 2026, 11, 8, 14048–14063: Table 1. Changes in Total Phenolic Compounds of Kombucha Samples Subjected to BKT, PB-BKT, PL-BKT and BB-BKT. Data are presented as mean ± standard deviation (n = 3). Values denoted by different letters within the same row indicate statistically significant differences (p &lt; 0.05). BKT: Blackthorn kombucha tea; PB-BKT: Propolis blackthorn kombucha tea; PL-BKT: Pollen blackthorn kombucha tea; BB-BKT: Bee bread blackthorn kombucha tea. n.d.: could not be detected." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2026_11_8_14048_14063_Table_1_Changes_in_Total_Phenolic_Compounds_of_Kombucha_Samples_Subjected_to_BKT_PB_BKT_PL_BKT_and_BB_BKT_5a50c7851f.jpg 159w," sizes="100vw" width="1054" height="1034"></p><p>The compound-level distribution suggests that the observed elevation in total phenolics is driven by selective, matrix-dependent enrichment. Bee bread is a functional food thanks to its bioactive compounds and chemical diversity. <a href="javascript:void(0);">(72)</a> The marked increase in chlorogenic acid concentration in BB-BKT, to 79.04 ± 4.66 μg/mL, was a key contributor to the elevated total phenolic content in this group. In contrast, chlorogenic acid remained undetectable or present at negligible levels in the other treatments. Likewise, the enrichment of thermosonicated kiwi juice with bee bread resulted in a statistically significant elevation in chlorogenic acid levels. <a href="javascript:void(0);">(68)</a> The highest catechin hydrate concentration was observed in PL-BKT (121.2 ± 3.36 μg/mL), indicating that pollen supplementation preferentially enhances the flavan-3-ol fraction. In contrast, the markedly elevated levels of quercetin (47.32 ± 2.07 μg/mL) and naringenin (17.59 ± 0.38 μg/mL) detected in PB-BKT support the flavonoid-enriching effect of propolis (<i>p</i> &lt; 0.05). In another study, propolis supplementation of thermosonicated yellow cherry juice was found to increase quercetin content significantly. Additionally, the exclusive emergence of chrysin in the enriched samples, particularly its pronounced accumulation in BB-BKT (66.42 ± 1.84 μg/mL), suggests that bee bread supplementation can substantially reshape the specific phenolic signature of the matrix. This interpretation is further supported by the highest rosmarinic acid level observed in BB-BKT (3.05 ± 0.24 μg/mL). Conversely, the absence of caffeic acid and the flavones fraction across all treatments (n.d.) indicates that the applied interventions exerted limited effects on specific phenolic subclasses.</p><h5><strong>3.5. Free Amino Acids (LC–MS)</strong></h5><p>The PL-BKT sample, which was supplemented with pollen, exhibited the highest free amino acid content (see <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.6c00008#tbl2">Table 2</a>). This outcome differed significantly from all other groups (<i>p</i> &lt; 0.05). Significant increases were observed in proline (47.37 mg/100 mL), leucine (4.10 mg/100 mL), and lysine (4.54 mg/100 mL), indicating that pollen, due to its high protein content, increases amino acid release during fermentation. In contrast, amino acid levels were lower in the sample supplemented with propolis alone (PB-BKT), and some amino acids (e.g., glutamic acid, histidine, threonine) were not statistically different from the BKT sample (<i>p</i> &gt; 0.05).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2026_11_8_14048_14063_Table_2_Effects_of_BKT_PB_BKT_PL_BKT_and_BB_BKT_on_Free_Amino_Acids_mg_100_m_L_f377c7c7e0.jpg" alt="ACS Omega 2026, 11, 8, 14048–14063: Table 2. Effects of BKT, PB-BKT, PL-BKT and BB-BKT on Free Amino Acids (mg/100 mL). The mean value, along with the standard deviation, is given for the data (n = 3). Values indicated by different letters within the same row differ significantly (p &lt; 0.05). BKT: Blackthorn kombucha tea; PB-BKT: Propolis blackthorn kombucha tea; PL-BKT: Pollen blackthorn kombucha tea; BB-BKT: Bee bread blackthorn kombucha tea." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2026_11_8_14048_14063_Table_2_Effects_of_BKT_PB_BKT_PL_BKT_and_BB_BKT_on_Free_Amino_Acids_mg_100_m_L_f377c7c7e0.jpg 159w," sizes="100vw" width="1055" height="1033"></p><h4><strong>4. Conclusions</strong></h4><p>This study demonstrated that kombucha enriched with <i>P. spinosa</i> L. juice and bee products (propolis, pollen, and bee bread) provides a robust model for functional beverage design through RSM-based optimization and advanced analytical characterization (HPLC–DAD, LC–MS/MS). From a sensory perspective, the highest overall acceptability was observed in the bee bread-enriched sample (8.32), which also exhibited the strongest antioxidant response (TPC 257.10 mg GAE/100 mL; TFC 36.16 mg CE/100 mL; DPPH• 57.05 μmol TE/mL). HPLC–DAD data revealed that total phenolics increased to 159.23–186.15 μg/mL following enrichment, and that marker compounds, such as chlorogenic acid and catechin derivatives, varied depending on the formulation. LC–MS/MS supported an increase in free amino acids (particularly proline) with pollen supplementation. Propolis addition highlighted the antidiabetic potential, yielding the highest enzyme inhibition (α-glucosidase: 40.7%; α-amylase: 42.02%). Although a partial reduction in bioactives was observed during in vitro digestion, the preservation of phenolic/flavonoid recovery within approximately the 21–30% range indicates that postdigestive activity may be sustained. Future studies are recommended to expand biomarkers using targeted/untargeted LC–HRMS-based metabolomic approaches, to correlate SCOBY microbiota (16S/ITS) with chemical profiles, and to evaluate shelf life and packaging stability (phenolic degradation kinetics, volatile profile), as well as in vivo/preclinical validation (glycemic response, bioaccessibility). A limitation of this work is that batch-specific botanical origin (palynological) identification of the commercial bee products was not performed; therefore, compositional variability due to botanical source cannot be fully excluded.</p></div>

From Chemistry to Functionality: HPLC–DAD/LC–MS/MS Characterization of Bee Product-Enriched Prunus spinosa L. Kombucha with In Vitro Antidiabetic Activity and Bioaccessibility

<p><strong>In the week of April 27, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Separation Science: Analytical Excellence Week 2026: Part 1- Understanding Pharmacopoeia and ACS Compliance</strong></h5><ul><li>Tu, 28.4.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6130">Registration</a></li></ul><p>Discover the critical role of compliant reagents in your lab and learn how to ensure that your analyses meet regulatory standards.</p><h5><strong>2. Agilent Technologies: PFAS &amp; Our Planet: Environmental Monitoring</strong></h5><ul><li>Tu, 28.4.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6140">Registration</a></li></ul><p>Explore evolving PFAS regulations and practical LC-MS/MS workflows for monitoring PFAS in water, soil, and air, including contamination control, sample prep, and reporting strategies.</p><h5><strong>3. Restek Corporation: Air Sampling Media Selection and Analysis</strong></h5><ul><li>Tu, 28.4.2026 14:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6160">Registration</a></li></ul><p>This presentation will give an overview of the selection of air sampling media, covering both whole air and sorbent sampling techniques.</p><h5><strong>4. Tosoh Bioscience: Tosoh Tuesday - What is MALS &amp; When is it Useful?</strong></h5><ul><li>Tu, 28.4.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6145">Registration</a></li></ul><p>Join Tosoh Tuesday to explore MALS fundamentals, practical implementation, and real-world SEC-MALS applications for polymer and biologics characterization.</p><h5><strong>5. Technology Networks: Mass Spectrometry in Drug Discovery: Covalent and Non-Covalent Screening Applications</strong></h5><ul><li>Tu, 28.4.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6114">Registration</a></li></ul><p>Identifying small-molecule binders for complex biological targets remains a major challenge in early drug discovery.</p><h5><strong>6. Thermo Fisher Scientific: From Sample to Structure: Crosslinking MS Made Practical - Part 1</strong></h5><ul><li>Tu, 28.4.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6115">Registration</a></li></ul><p>Crosslinking mass spectrometry (XL-MS) is transforming how researchers map protein–protein and protein–nucleic acid interactions.</p><h5><strong>7. SelectScience: Why researchers turn to reversed phase chromatography when purifying GLP-1</strong></h5><ul><li>Tu, 28.4.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6117">Registration</a></li></ul><p>Purifying synthetic peptides is a critical step in developing advanced biotherapeutics like GLP-1 receptor agonists.</p><h5><strong>8. Phenomenex: Fundamentals First Bio Series – SEC for Biologics</strong></h5><ul><li>We, 29.4.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6149">Registration</a></li></ul><p>Master SEC fundamentals for biopharma—covering principles, column selection, and troubleshooting with real-world applications in mAbs, AAVs, and nucleic acids.</p><h5><strong>9. SCIEX: Extending the power of LC-MS/MS: advanced workflows with QTRAP®</strong></h5><ul><li>We, 29.4.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6147">Registration</a></li></ul><p>Discover how QTRAP® workflows enhance LC-MS/MS performance with MS³ selectivity, improving sensitivity, reducing interference, and enabling confident analysis in complex matrices.</p><h5><strong>10. Metrohm: The Basics of Titration explained</strong></h5><ul><li>We, 29.4.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6129">Registration</a></li></ul><p>In this webinar, Robert Tobler, Senior Application Specialist Titration at Metrohm International Headquarters, will give you an introduction to the basics of titration.</p><h5><strong>11. Separation Science: Analytical Excellence Week 2026: Part 2 - Benefits of PFAS-Tested Consumables</strong></h5><ul><li>Th, 30.4.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6131">Registration</a></li></ul><p>Gain insights into the importance of PFAS-tested additives and solvents for reliable analysis and their impact on the quality of your results.</p><h5><strong>12. Evosep Biosystems: Next-Gen HCP Analysis in Biopharma</strong></h5><ul><li>Th, 30.4.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6151">Registration</a></li></ul><p>Discover how LC-MS is advancing biopharma workflows through scalable, high-throughput proteomics.</p><h5><strong>13. Bruker: Bridging Molecules and Genes: Integrating MALDI Imaging and Spatial Transcriptomics on a Single Tissue Section</strong></h5><ul><li>Th, 30.4.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6132">Registration</a></li></ul><p>Explore how integrating MALDI Imaging with spatial transcriptomics reveals tissue heterogeneity, molecular gradients, and disease-relevant patterns through advanced multimodal workflows.</p><h5><strong>14. Thermo Fisher Scientific: From Sample to Structure: Crosslinking MS Made Practical - Part 2</strong></h5><ul><li>Th, 30.4.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6116">Registration</a></li></ul><p>Crosslinking mass spectrometry (XL-MS) is transforming how researchers map protein–protein and protein–nucleic acid interactions.</p>

Webinars LabRulezLCMS Week 18/2026

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Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer

Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows.

<h4><strong>Superior performance in your routine quantitative analyses</strong></h4><p><strong>Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows. &nbsp;With solutions for today’s needs and technologies to overcome tomorrow’s challenges, explore what the adaptable, flexible, and proven Xevo TQ-XS Tandem Quadrupole Mass Spectrometer coupled with ACQUITY UPLC can afford your laboratory’s productivity and capabilities. &nbsp;</strong></p><div><div><div><div><ul><li><strong>Expanding your efficiencies</strong>: Maximize your laboratory’s potential in high sensitivity quantitative analysis by extending your capabilities, confidently and productively</li><li><strong>Performance that’s proven</strong>: Trust the proven Xevo TQ-XS to meet the analytical demands of your challenging applications , injection after injection</li><li><strong>Digesting your data</strong>: Reduce the burden in data handling with flexible and adaptable software solutions to meet your application and quality system needs</li><li><strong>Supporting your success</strong>: Have confidence that you will exceed your analytical requirements using Waters end to end solutions with flexible service and application focused training and support</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Quantitative analysis where <strong>high sensitivity instrument performance</strong> is required (e.g.,&nbsp;to reach <strong>low level concentrations (ppt)</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: The Xevo TQ-XS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg 245w," sizes="100vw" width="1024" height="545"></p><div><div><h3><strong>Expand your analytical capabilities with enhanced sensitivity</strong></h3><p>Delivering the next step in reliable sensitivity, the <strong>Xevo TQ-XS</strong> enables your laboratory to expand your analytical capacity and productivity. Whether seeking more sensitivity to detect your analytes routinely, looking to extend your scope of analytes with increased confidence or revise your workflow to reduce time and costs, explore what <strong>Xevo TQ-XS</strong>, coupled with <strong>ACQUITY UPLC</strong> and <strong>ACQUITY Premier Systems</strong> can offer your lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Vancomycin: Xevo TQ-XS versus Xevo TQ-S. On average, the analyte area counts on Xevo TQ-XS were >10x higher than area counts on Xevo TQ-S for Vancomycin." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg 245w," sizes="100vw" width="1024" height="295"></p></div></div><div><div><h3><strong>Proven performance you can trust for your challenging analyses</strong></h3><p>Whether looking to streamline your methods or advance your laboratory’s performance, explore how <strong>Xevo TQ-XS</strong>, coupled with <strong>LC (UPLC), GC (APGC) or SFC (UPC2)</strong> can benefit your challenging applications. Trust the proven <strong>Xevo TQ-XS</strong> to meet your <strong>analytical demands</strong>, injection after injection.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Representative liraglutide LLOQ (0.5 ng/mL) chromatogram, extracted from plasma, demonstrating sensitivity and selectivity with Xevo TQ-XS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg 245w," sizes="100vw" width="1024" height="536"></p></div></div><div><div><h3><strong>Software solutions to overcome a common bottleneck</strong></h3><p>While quantitation of targeted analytes can be a routine experiment, the volume of data acquired and generated for processing, review and management can be significant. <strong>Waters</strong>’ informatics platforms offer extensive toolsets to support efficient and compliant <strong>data handling</strong> to support your <strong>21 CFR 11 and ISO 17025</strong> environments.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: With the Xevo TQ-XS System, you’ll get robust results you can trust with the most demanding sample matrices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg 234w," sizes="100vw" width="1024" height="683"></p></div></div><div><div><h3><strong>Accelerating your success with award winning service</strong></h3><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with Waters comprehensive analytical solutions with expert training (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services.html"><strong>APS</strong></a>) and flexible and cost-effective solutions to advance your business with system service <strong>(</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services/flexchoice-instrument-service-coverage.html"><strong>FlexCHOICE</strong></a>), trade-ins and technological upgrades (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/FlexUP-Technology-Renewal-Program-%7C-Upgrade-Lab-Instruments/nav.htm?cid=135071972"><strong>FlexUP</strong></a>).</p></div></div></div></div></div></div>

Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry

From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.

<h3><strong>Defining Compact Performance</strong></h3><ul><li><strong>Robust Sensitivity Beyond Expectations</strong></li></ul><p><strong>From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.</strong></p><h4><strong>Reliable performance</strong></h4><p>Achieve your objectives in full with operational performance you can rely on. A Xevo TQ-S micro study analyzing mycotoxins in wheat flour (a complex matrix that can contaminate LC/MS instrumentation) showed consistent performance over 5 days of continuous use with 1000 injections and only 5-9% relative standard deviation (RSD) for peak areas.</p><h4><strong>Maximizing uptime</strong></h4><p>Get the most from your instrument and avoid time-consuming repair visits. Customers using the Xevo TQ-S micro will on average not need an unplanned service visit during the warranty period and for 3 years after.<strong>*</strong>&nbsp;</p><p><strong>*</strong>Source Waters internal service data on unplanned service visits for Xevo TQ-S micro issues that occur globally. Note that warranty period used is 1 year and planned visits for regular scheduled Performance Maintenance are recommended to ensure trouble-free operation</p><h4><strong>Achieve more with less</strong></h4><ul data-spread="false"><li>The Xevo TQ-S micro is 2-3X narrower than other instruments in its class, reducing laboratory space overhead costs.</li><li>Use of the Xevo TQ-S micro provides up to 34% lower electricity power consumption and associated heat production than other instruments in its class.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: With benchspace at a premium, choose an instrument designed to maximize performance per square inch." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg 245w," sizes="100vw" width="1024" height="300"></p><h4><strong>Flexibility to meet your analytical needs&nbsp;</strong></h4><p>With the most commonly used atmospheric pressure ionization source of ESI as standard, simply change chromatographic inlet or ionization source to extend your analytical capacity and meet changing demands.</p><h3><strong>Reliable Performance</strong></h3><h4><strong>Keeping Variability to a Minimum</strong></h4><p>Be confident that you will have reliable data over multi-day studies. Two experiments using the Xevo TQ-S micro provide evidence for the longer-term stability of this instrument. By monitoring peak areas whilst running continuous injections, you can see that the Xevo TQ-S micro won’t let you down.</p><p><strong>Experiment 1</strong> – 4 mycotoxins in wheat flour showed consistent performance over 5 days of continuous use with 1,000 injections and only 5-9% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 1 showing data for mycotoxins in wheat flour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg 245w," sizes="100vw" width="1221" height="647"></p><p><strong>Experiment 2</strong> – Acetaminophen in protein precipitated plasma also showed consistent performance over 6 ½ days of continuous use with 2,400 injections and only 4% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 2 - Acetominophen in protein precipitated plasma." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg 245w," sizes="100vw" width="1220" height="649"></p><p><strong>Less than 1%</strong> of Waters tandem quadrupole mass spectrometers require a detector replacement on an annual basis.<strong>*</strong></p><p><strong>*</strong>Source: Waters internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022.</p><h3><strong>Improving Efficiency</strong></h3><h4><strong>Lower Operational Costs and Improved Sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it. Many of our customers are actively working to address environmental sustainability while balancing the need to continually reduce operational costs. The Xevo TQ-S micro consumes less electricity than other instruments in its class and therefore produces less heat – lessening the need for air conditioning and lowering costs.</p><p><strong>Table 1:</strong> Instrument / Power Consumption / Heat Output</p><ul><li><strong>Waters Xevo TQ-S micro</strong> / 1250 W / 4,263 Btu/h</li><li><strong>Competitor B</strong> / 1452 W / 4,950 Btu/h</li><li><strong>Competitor A</strong> / 1600 W / 5,456 Btu/h</li><li><strong>Competitor C</strong> / 1960 W / 6,500 Btu/h</li></ul><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/account/sign-in.html"><strong>Xevo TQ-S micro Site Preparation Guide</strong></a><br>Note that power stated for scroll pump configuration. Option for rotary pump configuration is available</p><p>Power and heat outputs for mid tier TQ products, conversion factor 1W = 3.41 Btu/h</p></blockquote><h3><strong>Ultimate Productivity</strong></h3><h4><strong>Achieve More with Flexible Software Solutions</strong></h4><p>The Xevo TQ-S micro is available on both the waters_connect™ and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements.</p><ul data-spread="false"><li><strong>waters_connect™:</strong> Our modern, app-based software platform delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time.</li><li><strong>MassLynx™: </strong>A well-established software package delivering market-leading versatility and flexibility for all application areas.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Flexibility</strong></h3><h4><strong>Choose the Optimal Separation and Ionization Technique for Your Application</strong></h4><p>Waters' market-leading separation technologies include the ACQUITY™ UPLC™ family of LC systems and APGC™. Application flexibility is further enhanced by the range of quickly interchangeable ion source options made possible by universal ion source architecture.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: UPLC/MRM data on Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg 245w," sizes="100vw" width="1024" height="384"></p><h3><strong>Optimal Support</strong></h3><h4><strong>Ensure Your Success with World-Renowned Services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ-S micro, you can:</strong></p><h4><strong>Get up and running quickly&nbsp;</strong></h4><p>Get onsite training and consultation to integrate the Xevo TQ-S micro into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet your lab’s unique requirements</strong></h4><p>Protect your high-performance instrument investment with comprehensive &nbsp;portfolio of service plans such as Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitate compliance</strong></h4><p>Simplify the process of qualification, validation, and recordkeeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce total cost of ownership</strong></h4><p>FlexCAPITAL™<strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage your existing technology</strong></h4><p>With the FlexUP™ technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ-S micro – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>**</strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

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