Ask any analytical chemist which hyphenated technique has become indispensable over the past decade, and the answer will almost certainly be the same: tandem chromatography–mass spectrometry. Whether it is <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis">LC–MS/MS</a> quantifying a novel biologic’s metabolic fate, or <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-gc-ms/ms-analysis">GC–MS/MS</a> chasing per- and polyfluoroalkyl substances (PFAS) down to sub-part-per-trillion levels in municipal water, the combination of chromatographic separation with the specificity of tandem mass detection has become the analytical workhorse of choice across virtually every regulated sector.Below we examine the key forces propelling this expansion, from biopharma pipeline dynamics and PFAS regulatory mandates to AI-driven automation and reshoring of pharmaceutical manufacturing—and explore what each trend means for laboratories managing sample preparation and analytical workflows.<h3>Biopharma: The Engine Room of LC–MS/MS Demand</h3><h4>GLP-1 Agonists and the Metabolomics Gold Rush</h4>The explosive commercial and scientific interest in GLP-1 receptor agonists—<a target="_blank" rel="noopener noreferrer" href="https://www.sepscience.com/advancing-glp-1-peptide-analysis-chromatography-challenges-and-innovations-12163">semaglutide and related peptide therapeutics </a>for diabetes and obesity—has dramatically expanded the analytical demands placed on tandem MS platforms. Discovery programs require precise quantification of peptide drug candidates and endogenous biomarkers across complex biological matrices. These workflows rely on high-sensitivity LC–MS/MS for pharmacokinetic profiling, receptor occupancy studies, and metabolomics characterization. Metabolomics is, in fact, projected to be the fastest-growing application segment in mass spectrometry, driven in part by its growing role in cancer screening, biomarker discovery, and metabolic disease research.I have been spending more time learning about GLP-1s because this is the hot topic that people want to discuss on the Concentrating on <a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL?si=n9GLz9zjSCOrVfXPxFPhng&amp;nd=1&amp;dlsi=52868e027aad4d22">Chromatography podcast</a>. With that said, I was astounded looking at CNBC.com during breakfast this morning to see that <a target="_blank" rel="noopener noreferrer" href="https://www.cnbc.com/2026/03/21/glp-1-diets-restaurants-protein-fiber-weight-loss-drugs.html">one in eight Americans are currently taking one of these drugs such as Ozempic</a>.<h4>Antibody–Drug Conjugates and Gene Therapy: Complexity at Every Step</h4>The ascent of antibody–drug conjugates (ADCs) and gene therapies has introduced a new level of analytical complexity. ADCs blend the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads—and characterizing the linker chemistry, drug-to-antibody ratio (DAR), and conjugate stability demands high-resolution LC–MS/MS at every stage from discovery through QC release testing. Gene therapy vectors require equally rigorous characterization of impurities, aggregates, and empty/full capsid ratios.This translates into a direct need for low-evaporation, high-recovery concentration methods that preserve labile protein structures and maintain sample integrity prior to LC–MS/MS injection. <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">Nitrogen evaporation workflows</a> that minimize oxidative stress and maintain sample temperature are increasingly critical in these pipelines.<h4>Precision Medicine and Multi-Omics Integration</h4>The shift toward precision medicine has accelerated adoption of high-throughput, multi-analyte MS platforms. Proteomics, metabolomics, and lipidomics workflows are converging on a single analytical platform—tandem MS—and generating datasets of a scale and complexity that were unimaginable ten years ago.Make no mistake: the triple quadrupole serves an irreplaceable role in quantitative targeted analysis. At the same time, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3">Orbitrap </a>and Q–TOF hybrid platforms are growing rapidly as researchers demand full-scan accurate mass for untargeted discovery.<h3>Environmental Mandates: PFAS Testing Drives Adoption</h3>Environmental testing is something that every person, chemist or not, can understand the importance of. Mounting mandates from the U.S. Environmental Protection Agency and European regulators regarding PFAS—the “forever chemicals” whose extraordinary environmental persistence is matched only by the analytical challenge of detecting them at trace levels—have created immediate, compliance-driven investment in LC–MS/MS infrastructure.<h4>The Regulatory Framework Chemists Need to Know</h4>The EPA has codified a suite of LC–MS/MS-based methods as the analytical standard for PFAS in water and solid matrices:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe">EPA Method 533</a>: Weak anion exchange SPE combined with LC–MS/MS; covers 25 PFAS including short-chain compounds in drinking water.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination">EPA Method 537.1</a>: Reversed-phase SPE followed by LC–MS/MS; covers 18 PFAS including the GenX compound, with method detection limits in the low ng/L range.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/en/solutions/environmental/water-testing/pfas-in-water/us-epa-method-8327?srsltid=AfmBOooCY1pcavj7B1PH-75d3HO4BGDglNlhmyTyrpDY3zvUksMO1dlg">EPA Method 8327</a>: LC–MS/MS for selected PFAS in prepared extracts of aqueous and solid matrices.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633">EPA Draft Method 1633</a>: The emerging benchmark for PFAS in non-aqueous matrices—aqueous, solid, biosolids, and tissue—quantifying up to 40 PFAS.</li></ul>All of these methods designate LC–MS/MS, specifically LC coupled to triple quadrupole or tandem-in-time platforms operating in negative electrospray ionization mode with multiple reaction monitoring (MRM), as the required or recommended analytical technique. PFAS analysis is, at its core, an LC–MS/MS problem.<h4>The Sample Preparation Bottleneck</h4>Chemists who have worked with PFAS methods understand the particular demands they place on sample preparation. The ubiquity of<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/tackling-pfas-contamination-practical-insights-from-epa-537.1-method-development"> PFAS in laboratory materials</a>—PTFE tubing, some SPE sorbents, standard bench supplies—means that blank contamination control is as analytically demanding as the detection itself. EPA 537.1 requires that sample volumes of approximately 250 mL be extracted and reconstituted in as little as 1 mL, creating a 250:1 concentration factor that can expose even trace contamination in the sample processing chain. The installation of a delay column between the LC pump and autosampler to prevent instrument background interference is now standard practice.This is precisely where robust, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5385">inert nitrogen evaporation </a>systems earn their keep. PFAS workflows that use nitrogen-assisted evaporation to concentrate extracts prior to reconstitution benefit from materials that avoid PTFE and other fluoropolymers that can leach PFAS background—a consideration Organomation addresses in its concentration system designs.The analytical community is also moving beyond targeted PFAS analysis. High-resolution accurate mass (HRAM) spectrometry via Orbitrap technology, paired with non-targeted screening workflows, is gaining traction for the identification of the more than 5,000 currently catalogued PFAS compounds and the novel structures that continue to emerge. LC–MS/MS remains the quantitative gold standard; HRAM provides the discovery layer.<h3>Technological Trends Reshaping the LC–MS/MS Workflow</h3><h4>Artificial Intelligence and Automated Data Interpretation</h4>The datasets generated by modern tandem MS platforms—particularly in omics applications—are too large and too complex for conventional manual review. AI-driven spectral deconvolution, automated peak integration, and AI-assisted hypothesis generation are now embedded in the software suites accompanying leading instruments. <a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/about/newsroom/presrel/2022/17feb-gp22004.html?srsltid=AfmBOop3warRIaEojXM2YyMML6RXfMIDzE-Wm0h-SiKkkocBeeET2m7u">Agilent’s acquisition of Virtual Control’s ACIES </a>software specifically to automate LC–MS and GC–MS data analysis is emblematic of this direction.For laboratory managers, AI integration means smaller specialized teams can operate high-throughput multi-analyte workflows—but it also means that the front-end sample preparation must be even more reproducible, since algorithmic interpretation amplifies inconsistencies introduced upstream.<h4>Online SPE Coupling and “Chromatography Without Walls”</h4>A significant trend is the integration of solid-phase extraction directly into the HPLC flow path—so-called online SPE–HPLC coupling. Systems that combine extraction and chromatographic separation in a single analytical instrument reduce manual transfer steps, minimize the risk of sample loss or contamination, and dramatically increase throughput. For analytes at very low concentrations, online SPE provides the on-column concentration capability that traditional offline preparation achieves with manual evaporation steps.That said, offline sample preparation—including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">nitrogen-assisted evaporation</a> under controlled conditions, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2407">liquid–liquid extraction</a>, and protein precipitation—retains significant advantages in flexibility, matrix handling, and the ability to process sample volumes that exceed online system capacity. The two approaches are increasingly complementary rather than competitive in well-designed analytical laboratories.<h4>High-Purity Solvents and Reference Materials</h4>As detection limits push further into the femtogram range and regulatory methods demand demonstrable blank performance, the quality of analytical consumables—mobile phase solvents, derivatization reagents, reference standards—has moved from background consideration to front-of-mind. Method validation in regulated environments now routinely requires vendor certification of solvent purity at a level that directly interfaces with instrument performance.<h3>The Ever-Present Need for Sample Evaporation</h3>As LC–MS/MS methods push detection limits lower, the analytical burden shifts increasingly upstream. The quality of the concentration, cleanup, and reconstitution steps preceding injection determines whether the instrument’s theoretical sensitivity is achievable in practice.Several specific developments are particularly relevant:<ul><li>ADC and gene therapy characterization workflows require gentle, low-temperature evaporation that preserves protein structure and prevents aggregation prior to LC–MS/MS. Nitrogen evaporation under controlled conditions is the preferred approach.</li><li>PFAS trace analysis demands evaporation systems constructed from PFAS-inert materials, with rigorous attention to avoiding fluoropolymer surfaces throughout the sample path.</li><li>High-throughput pharmaceutical QC driven by reshoring demands parallel processing capability—multi-position evaporators that maintain consistent flow and temperature across all positions simultaneously.</li><li>Multi-omics and metabolomics workflows generate large sample batches that benefit from automated, walk-away evaporation with programmable endpoints to ensure reproducible final volumes across a cohort.</li></ul>Tandem chromatography–mass spectrometry is not merely growing; it is becoming structurally embedded in the analytical workflows of every major regulated industry. The convergence of biopharma complexity, PFAS regulatory mandates, AI-enabled data analysis, and pharmaceutical reshoring is creating a multi-year demand cycle that will require laboratories to invest not only in instruments, but in the entire sample preparation ecosystem that makes those instruments perform.For analytical chemists, the practical takeaway is this: as mass spectrometry sensitivity continues to advance, the sample preparation step becomes the binding constraint on method performance. Whether you are developing a new PFAS method to meet EPA 1633, characterizing an ADC’s drug-to-antibody ratio, or running a 500-sample metabolomics cohort overnight, the reliability and cleanliness of your concentration and cleanup workflow determines the quality of every data point that follows.&nbsp;

The Continued Rise of Tandem Chromatography–Mass Spectrometry

News from LabRulezLCMS Library - Week 27, 2026

🎤Dr. Christopher Reid (Professor of Chemistry and Biochemistry at Bryant University in Rhode Island)In this episode of Concentrating on Chromatography, host Dave Oliva sits down with Chris Reid to explore how chemical biology and LC-MS are being used to tackle one of the most urgent global challenges: antimicrobial resistance.As antibiotic resistance continues to rise—and new drug development struggles to keep pace—researchers are looking beyond traditional approaches. Instead of targeting how bacteria build their cell walls, Chris’s work focuses on how they break them down, opening the door to entirely new antimicrobial strategies.<h4>What You’ll Learn in This Episode:</h4><ul><li>Why antimicrobial resistance is accelerating globally</li><li>What peptidoglycan is and why it’s essential to bacterial survival</li><li>How targeting cell wall degradation differs from traditional antibiotics</li><li>The strategy behind designing small molecule probes and inhibitors</li><li>How LC-MS is used to analyze peptidoglycan fragments and enzyme activity</li><li>Key analytical challenges: complex mixtures, low-abundance species, and structural similarity</li><li>The importance of sample preparation and reproducibility in LC-MS workflows</li><li>How this research could lead to new antibiotic targets</li></ul><h3>Video Transcription</h3><h4>The Growing Challenge of Antibiotic Resistance</h4>According to Reid, antibiotic resistance is increasing across a broad spectrum of bacterial pathogens that were once readily treated with existing therapies. In some cases, clinicians must now rely on only a handful of last-line antibiotics, while resistance is also rising in diseases such as tuberculosis.One of the major obstacles is the limited commercial incentive to develop entirely new antibiotics. Because bacterial resistance can emerge relatively quickly after a drug reaches the market, pharmaceutical companies often favor modifying existing antibiotics or combining them with resistance-modifying agents rather than investing in completely new drug classes. As a result, genuinely novel antibacterial targets remain urgently needed.<h4>Why the Bacterial Cell Wall Remains an Attractive Target</h4>The bacterial cell wall consists primarily of peptidoglycan, a highly cross-linked polymer that provides structural integrity, maintains cell shape, and enables bacterial growth and division.Many widely used antibiotics—including the β-lactam antibiotics such as penicillins—target enzymes responsible for synthesizing or cross-linking peptidoglycan. These pathways have proven highly successful therapeutic targets because peptidoglycan is unique to bacteria and absent from human cells, minimizing unwanted effects on the host.However, most existing antibiotics target only specific stages of peptidoglycan biosynthesis. Reid's research explores another part of this complex pathway: enzymes responsible for degrading the carbohydrate backbone of peptidoglycan during normal bacterial growth and remodeling. These enzymes may represent an underexplored class of antimicrobial targets capable of overcoming existing resistance mechanisms.<h4>Targeting the Glycan Backbone</h4>A key advantage of focusing on the carbohydrate backbone is its remarkable conservation across both Gram-positive and Gram-negative bacteria.Whereas the peptide components of peptidoglycan vary considerably between bacterial species—and frequently acquire mutations associated with antibiotic resistance—the glycan backbone remains highly conserved and tolerates relatively few structural modifications.This biological constraint makes enzymes acting on the glycan backbone particularly attractive targets. Reid's group developed a series of small-molecule probes and inhibitors designed to recognize enzymes known as N-acetylglucosaminidases, which cleave glycosidic bonds within peptidoglycan and generate soluble degradation products.Rather than beginning with purified enzymes, the researchers adopted a top-down phenotypic screening strategy. Candidate compounds were first evaluated for their ability to inhibit bacterial growth before progressively narrowing the list of potential molecular targets through genetic studies, microscopy, enzyme assays, and biochemical characterization. This iterative workflow ultimately identified compounds capable of inhibiting the desired enzyme class while simultaneously providing valuable chemical probes for studying bacterial cell wall biology.<h4>LC-MS as a Central Analytical Tool</h4>Liquid chromatography coupled with mass spectrometry plays a central role throughout the project by enabling detailed characterization of structural changes occurring within peptidoglycan after bacterial cells are treated with candidate inhibitors.Because intact peptidoglycan is an insoluble polymer, sample preparation begins with isolation of the bacterial cell wall through detergent extraction and differential centrifugation. Additional purification steps remove proteins, nucleic acids, and teichoic acids before enzymatic digestion converts the insoluble material into soluble fragments suitable for chromatographic analysis.The resulting digest is analyzed by LC-MS to examine changes in the distribution of peptidoglycan fragments. Chromatographic retention times provide an immediate indication of changes in cross-linking, with larger oligomers such as trimers and tetramers generally eluting later than monomeric fragments. Mass spectrometry then confirms the identity of these fragments by measuring their intact molecular masses, while tandem MS experiments can provide further structural information when required.<h4>Sample Preparation Determines Data Quality</h4>Reid emphasized that sample preparation represents one of the most critical—and challenging—stages of the entire workflow.Because peptidoglycan analysis involves multiple purification, digestion, and reduction steps, even minor procedural differences between samples can introduce analytical artifacts that complicate biological interpretation.Maintaining strict consistency throughout sample preparation is therefore essential. Appropriate controls must accompany every experiment, ensuring that observed chromatographic and mass spectrometric differences truly reflect biological responses rather than experimental variability. The complexity of bacterial cell wall composition further increases the analytical challenge, as subtle differences in amino acid substitutions and low-abundance cross-linked species can complicate LC-MS data interpretation.<h4>Chemical Biology for Future Antibiotic Discovery</h4>Although the identified compounds may eventually serve as starting points for antibiotic development, Reid views them primarily as chemical biology tools.By selectively inhibiting individual enzymes, these probes allow researchers to investigate previously unexplored aspects of bacterial cell wall remodeling that cannot easily be studied using classical genetic approaches alone.The research team is now expanding this strategy by combining their probes with proximity-labeling proteomics and mass spectrometry, aiming to map protein interaction networks associated with bacterial cell wall degradation. Such studies may reveal entirely new antibacterial targets and provide deeper insight into the biological processes governing bacterial growth and division.Ultimately, the work illustrates how integrating synthetic chemistry, microbiology, molecular biology, and advanced LC-MS can accelerate the search for innovative therapeutic strategies against antimicrobial resistance. As existing antibiotics become progressively less effective, multidisciplinary approaches such as these may play an increasingly important role in identifying the next generation of antibacterial targets.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

 Fighting Antibiotic Resistance with LC-MS: Targeting Bacterial Cell Walls

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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ECOM ECS23PC Quaternary Preparative Gradient System with Fraction Collector

A highly effective preparative system containing a UV-VIS DAD detector, a preparative pump, a gradient box with PC, and a fraction collector. The detector allows measuring at four wavelengths at the same time or an informative scan.

<div style="display:block;" aria-labelledby="tab_item-0">A highly effective preparative system containing a UV-VIS DAD detector, a preparative pump, a gradient box with PC, and a fraction collector. The detector allows measuring at four wavelengths at the same time or an informative scan.Communication is through RS232 or Ethernet (LAN). An additional PC A/D converter card is not required for this system. The system contains a manual injector and ECOMAC software which include drivers for all ECOM units.It is necessary to purchase an OS for the system - in most cases, we recommend OEM Windows OS (P/N: ABB90000) or Linux (on request). It is also possible to purchase a wireless mouse and keyboard set (P/N: EPC-0028) and a computer monitor (P/N: EPC-0027).<h3>Main parts</h3><h4>TOY18DAD H 600 DETECTOR</h4>A UV-VIS diode array detector, which allows measuring the absorbance of four wavelengths in the range of 200 – 600 nm simultaneously in one cell just as visualization of whole spectra. It is possible to use the detector in flash and preparative applications. Standardly is assembled preparative cell PLCC 15 but other cells are available.<h4>ECP2300 PREPARATIVE PUMP</h4>This isocratic pump works with Gradient Box ECB2007PC as a quaternary gradient pump. The flow rate range is 0.1-300 ml/min and the pressure limit at 15 MPa. Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.<h4>ECB2005PC GRADIENT BOX WITH PC, WITHOUT DEGASSER</h4>The box is suited for handling liquids in ECOM gradient systems. It accommodates a container for solvent bottles and a four-way gradient valve. A four-way gradient valve is controlled from the pump ECP2300. In this box is assembled an industrial PC board. This solution allows the installation of OS (Windows or Linux) and chromatography SW ECOMAC or Clarity.&nbsp;<h4>ECF2096 FRACTION COLLECTOR</h4>Fractions are collected according to a chosen method which can be created manually by keyboard, just as using ECOMAC software. Analog input allows collecting based on detector signal. Racks for 9, 21, and 40 ml tubes.<h4>ECOMAC CHROMATOGRAPHY SOFTWARE</h4>This system is fully controlled by ECOMAC software, which is also a part of delivery. It allows all units control, gradient creation, and fraction collecting.<h3>SYSTEM CONTAINS&nbsp;</h3>Pcs / Description (P/N)<ul><li>1x / TOY18DAD H 600 Four Channel Detector (ANW0000X)</li><li>1x / ECB2005PC Gradient Box with PC, without Degasser (ABBPC00X)</li><li>1x / ECP2300 Preparative Pump (ACE0000X)</li><li>1x / ECOMAC software (SA100000)</li><li>1x / ECF2096 Fraction collector (AFA0000X)</li><li>1x / Preparative injection valve 1/8”; 2ml loop (SY2032022)</li><li>1x / Accessory for prep. system series 2000 (ASP00180)</li></ul>Note: The system can be equipped with detectors with different wavelengths ranges and pumps with different flow rates from ECOM production.</div>

ECOM ECP201LG Gradient Preparative Pump 1000 mL/min

An innovative, powerful, and cost-effective unit for preparative LC separations with high pressure. 4 low pressure gradient valves, flow up to 1000 mL/min. 

<div style="display:block;" aria-labelledby="tab_item-0">The ECP201L Preparative Pump is an innovative, powerful, and cost-effective unit for preparative liquid chromatography where high pressure is needed. The pump with 4 low-pressure valves delivers a flow rate of up to 1000 mL/min at a very high output pressure of up to 15 MPa (2176 psi).<h3>Main features and benefits</h3><h4>Durability</h4>The pump is constructed for high pressure and flow rates. This makes it suitable for day-to-day long-term use in production<h4>Wide application possibilities</h4>The unit is used for pharmaceutical separations and plant extract purification, such as cannabinoids, peptides, and oligonucleotides. Also, it has much wider use in other chemical production, such as dosing into chemical reactors, and in various laboratory uses. Another advantage is the usability of the same device for separation method development.<h4>Smart controls and diagnostics</h4>It is easy to operate, especially with ECOMAC and Clarity software. This makes unit management powerful and convenient. The basic version of the ECOMAC software is available free of charge. It is also used for service and diagnostics.<h4>Other useful features</h4><ul><li>A new learning algorithm for pulsation suppression</li><li>A leakage sensor</li><li>A seal wash kit for longer piston seal life</li><li>Also available in configurations made of certified bio-inert materials</li></ul><h3>Parameters</h3><ul><li>Flow rate: 1 – 1000 ml/min</li><li>Maximum operating pressure in the pump: 15 MPa up to 1000 ml/min</li><li>Flow rate setting: 1 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 1 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials in the pump: stainless steel, PEEK, TefzelTM, Kalrez®, ceramic, seals GFP (PTFE) by default or UHMW-PE on request</li><li>Control: RS232, Ethernet(LAN), USB</li><li>Output capillary outer diameter: 1/8 "</li><li>Input tubing outer diameter: 3/8 ”</li><li>Number of gradient valves*: 4 (A,B,C,D)</li><li>Orifice: 5 mm</li><li>Fluid temperature: 5 - 90°C</li><li>Connecting thread: 5/8" - 18 UNF</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 500 VA</li><li>Weight of the complete set: 30 kg (66.14 lb)</li><li>Dimensions (w x h x d) of the complete set: 340 x 170 x 640 mm (13.4 x 6.7 x 25.2 in)</li></ul></div>

ECP2050 Preparative Pump

Preparative HPLC pump with flow-rate ranges of 0.001 to 50 ml/min. 

<div style="display:block;" aria-labelledby="tab_item-0">This pump works as an isocratic pump and together with a gradient box also as a gradient pump.These powerful and durable pumps are suitable for preparative applications in low- and high-pressure liquid chromatography across the chemical industry. They are designed with 2 pump heads connected in parallel with a piston diameter of 3/8”.Many improvements make these pumps more reliable, including a new learning algorithm for pulsation suppression and a leakage sensor. The pumps can operate in two modes, i.e. using constant pressure or the newly added option of constant flow rate. New material versions have been added-in beyond to stainless steel A316L, also Hastelloy, titanium and PEEK for biocompatible applications.<h4>Gradient function</h4>These pumps work as isocratic pumps, and, together with ECOM gradient boxes, they also work as gradient pumps. Gradient boxes ECB2007, ECB2007PC are equipped with a four-way gradient mixing valve and must be ordered together with the pump. These sophisticated units allow for achieving a precise low-pressure gradient, i.e. gradual changes of solvent composition by mixing up to four liquids at the pump‘s entry. The gradient profile can be defined via a computer or manually using a display and a keypad. Without the use of a gradient box, the pump works as isocratic, with the option of one solvent and the composition of the mobile phase being chosen by the user.Customers can use the pistons‘ back-washing function, after working, for example, with a buffered mobile phase.<h4>Seals</h4>All pumps are delivered with GFP (PTFE) seals by default. You can order the pumps with UHMW-PE seals, which are considered the optimal recommended choice.<h4>Software support</h4>The pumps are supported by ECOMAC and Clarity software.<h3>Main features and benefits</h3><ul><li>All models include a display and keyboard for manual control</li><li>&nbsp;Precise low-pressure gradient mixing (when connected with a gradient module)</li><li>Very good durability and reliability with proper maintenance</li><li>Extended number of wetted material versions – not only stainless steel but also Hastelloy, titanium and PEEK for biocompatible applications</li><li>Piston back-washing function for work with buffered or aggressive mobile phases</li><li>New learning algorithm for pulsation suppression</li><li>Integrated leakage sensor</li><li>Heating unit for pump heads available</li><li>Custom pump modifications of request</li></ul>This pump is equipped with the Pressure Compensation Learning algorithm. Thanks to this smart adaptive process, the pump regulates the rotation speed of the camshaft and measures its impact on pressure pulsation to minimize the output pulsation as much as possible. The algorithm, due to its adaptive capacity, is applicable for many combinations of pump working conditions (solvents, columns, etc.).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_ECP_2200_Preparative_Pump_5_b84832f1e8.jpg" alt="ECOM: ECP2050 - Preparative Pump - Pressure Compensation Learning algorithm " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_ECP_2200_Preparative_Pump_5_b84832f1e8.jpg 188w," sizes="100vw" width="700" height="580"><h3>Optional configurations/variants</h3>Pump head heating unit, see the accessories shown below. In case you would like this function for your pump, add also the heating unit to&nbsp;your cart. (Also can be found in the Accessories product category).<h5>PN / Wetted parts of pumping block</h5><ul><li>ACCH000X / Hastelloy</li><li>ACCP000X /<span style="-webkit-text-stroke-width:0px;display:inline !important;float:none;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"> PEEK</li><li>ACC0000X / Stainless steel</li><li>ACCT000X / Titanium</li></ul><h4>Parameters:</h4><ul><li>Flow rate: 0.001 – 50 ml/min</li><li>Maximum operating pressure: 30 MPa (4351 psi)</li><li>Flow rate setting: 0.1 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 0,5 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials: Stainless steel or Hastelloy or Titanium or PEEK + PEEK, TefzelTM, PE, ceramics, seals&nbsp;</li><li>Communication: RS232, Ethernet (LAN), USB, Remote digital I/O</li><li>Power supply: 100 240V 50/60Hz 250VA</li><li>Dimensions W x H x D: 280 x 135 x 498 mm (11.02 x 5.12 x 18.23 in)</li><li>Weight: 12 kg (26,5 lb)</li><li>Output capillary outer diameter: 1/16”</li><li>Upper pressure limit (MPa): 0,1 – 30 (4351PSI)</li><li>Precision of pressure measurement: ± 2%</li><li>Supported Gradient Box: ECB2005, ECB2005PC</li><li>Pressure Compensation Learning: yes&nbsp;</li></ul></div>

ECOM ECP2100 Preparative Pump

 Preparative HPLC pump with a flow-rate range up to 100 ml/min. 

<div style="display:block;" aria-labelledby="tab_item-0">Innovated pumps ECP2100 work as isocratic pumps and together with a gradient box also as a gradient pump. These powerful and durable pumps are suitable for preparative applications in low- and high-pressure liquid chromatography across the chemical industry. They are designed with 2 pump heads connected in parallel with a piston diameter of 3/8”.Many improvements make these pumps more reliable, including a new learning algorithm for pulsation suppression and a leakage sensor. New material versions have been added-in, beyond to stainless steel A316L, also Hastelloy, titanium and PEEK for biocompatible applications.The pumps can operate in two modes, i.e. using constant pressure or using the newly added option of constant flow rate. The ECP2100 pump now has an innovated spring-loaded outlet check-valve.<h4>Gradient function</h4>These pumps work as isocratic pumps, and, together with ECOM gradient boxes, they also work as gradient pumps. Gradient boxes ECB2007, ECB2007PC are equipped with a four-way gradient mixing valve and must be ordered together with the pump. These sophisticated units allow for achieving a precise low-pressure gradient, i.e. gradual changes of solvent composition by mixing up to four liquids at the pump‘s entry. The gradient profile can be defined via a computer or manually using a display and a keypad. Without the use of a gradient box, the pump works as isocratic, with the option of one solvent and the composition of the mobile phase being chosen by the user.Customers can use the pistons‘ back-washing function, after working, for example, with a buffered mobile phase.<h4>Seals</h4>All pumps are delivered with GFP (PTFE) seals by default. You can order the pumps with UHMW-PE seals, which are considered the optimal recommended choice.<h4>Software support</h4>The pumps are supported by ECOMAC and Clarity software.<h3>Main features and benefits</h3><ul><li>All models include a display and keyboard for manual control</li><li>Precise low-pressure gradient mixing (when connected with a gradient module)</li><li>Very good durability and reliability with proper maintenance</li><li>Extended number of wetted material versions – not only stainless steel but also Hastelloy, titanium and PEEK for biocompatible applications</li><li>Piston back-washing function for work with buffered or aggressive mobile phases</li><li>New learning algorithm for pulsation suppression</li><li>Integrated leakage sensor</li><li>Heating unit for pump heads available</li><li>Custom pump modifications of request</li></ul>This pump is equipped with the Pressure Compensation Learning algorithm. Thanks to this smart adaptive process, the pump regulates the rotation speed of the camshaft and measures its impact on pressure pulsation to minimize the output pulsation as much as possible. The algorithm, due to its adaptive capacity, is applicable for many combinations of pump working conditions (solvents, columns, etc.).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_ECP_2200_Preparative_Pump_5_b84832f1e8.jpg" alt="ECOM: ECP2100 - Preparative Pump - Pressure Compensation Learning algorithm " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_ECP_2200_Preparative_Pump_5_b84832f1e8.jpg 188w," sizes="100vw" width="700" height="580"><h3>Optional configurations/variants</h3>Pump head heating unit, see the accessories shown below. If you would like this function for your pump, add the heating unit to&nbsp;your cart. (Also can be found in the Accessories product category).PN / Wetted parts of pumping block<ul><li>ACCH000X / Hastelloy</li><li>ACCP000X /<span style="-webkit-text-stroke-width:0px;display:inline !important;float:none;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"> PEEK</li><li>ACC0000X / Stainless steel</li><li>ACCT000X / Titanium</li></ul><h4>Parameters:</h4><ul><li>Flow rate: 0.1 – 100 ml/min</li><li>Maximum operating pressure: 30 MPa (4351 psi)</li><li>Flow rate setting: 0.001 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 0,5 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Communication: RS232, Ethernet (LAN), USB, Remote digital I/O</li><li>Power supply: 100 240V 50/60Hz 250VA</li><li>Dimensions W x H x D: 280 x 135 x 498 mm (11.02 x 5.12 x 18.23 in)</li><li>Weight: 12 (26,5 lb)</li><li>Output capillary outer diameter: 1/16”</li><li>Upper pressure limit (MPa): 1– 30 (4351PSI)</li><li>Precision of pressure measurement: ± 2%</li><li>Supported Gradient Box: ECB2005, ECB2005PC</li><li>Display, keypad: yes&nbsp;</li><li>Pressure Compensation Learning: yes</li></ul></div>

ECOM ECP2300 Preparative Pump

Powerful and durable pumps for preparative applications in low- and high-pressure liquid chromatography, designed with 2 pump heads connected in parallel

<div style="display:block;" aria-labelledby="tab_item-0">Powerful and durable pumps suitable for preparative applications in low- and high-pressure liquid chromatography across the chemical industry. An extended&nbsp;number of wetted material versions – not only stainless steel but also Hastelloy, titanium, and PEEK.&nbsp;ECP2300 are designed with 2 pump heads connected in parallel with a piston diameter of 3/8”.Many improvements make these pumps more reliable, including a new learning algorithm for pulsation suppression and a leakage sensor. The pumps can operate in two modes, i.e. using constant pressure or using the newly added option of constant flow rate.<h4>Gradient function:&nbsp;</h4>These pumps work as isocratic pumps, and, together with ECOM gradient boxes, they also work as gradient pumps. Gradient boxes ECB2005, and ECB2005PC are equipped with a four-way gradient mixing valve and must be ordered together with the pump. These sophisticated units allow for achieving a precise low-pressure gradient, i.e. gradual changes of solvent composition by mixing up to four liquids at the pump‘s entry. The gradient profile can be defined via a computer or manually using a display and a keypad. Without the use of a gradient box, the pump works as isocratic, with the option of one solvent and the composition of the mobile phase being chosen by the user.Customers can use the pistons‘ back-washing function, after working, for example, with a buffered mobile phase.<h4>Seals:&nbsp;</h4>All pumps are delivered with GFP (PTFE) seals by default. You can order the pumps with UHMW-PE seals, which are considered the optimal recommended choice.<h4>Software support:&nbsp;</h4>The pumps are supported by ECOMAC and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity software</a>.<h3>Features and Benefits</h3><ul><li>All models include a display and keyboard for manual control</li><li>Precise low-pressure gradient mixing (when connected with a gradient module)</li><li>Very good durability and reliability with proper maintenance</li><li>Extended number of wetted material versions – not only stainless steel but also Hastelloy, titanium and PEEK for biocompatible applications</li><li>Piston back-washing function for work with buffered or aggressive mobile phases</li><li>New learning algorithm for pulsation suppression</li><li>Integrated leakage sensor</li><li>Custom pump modifications of request</li></ul>This pump is equipped with the Pressure Compensation Learning algorithm. Thanks to this smart adaptive process, the pump regulates the rotation speed of the camshaft and measures its impact on pressure pulsation to minimize the output pulsation as much as possible. The algorithm, due to its adaptive capacity, is applicable for many combinations of pump working conditions (solvents, columns, etc.).This pump is equipped with the Pressure Compensation Learning algorithm. Thanks to this smart adaptive process, the pump regulates the rotation speed of the camshaft and measures its impact on pressure pulsation to minimize the output pulsation as much as possible. The algorithm, due to its adaptive capacity, is applicable for many combinations of pump working conditions (solvents, columns, etc.).Service videos -Seals replacement and&nbsp;Valve replacement :&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.ecomsro.com/support/service-videos">https://www.ecomsro.com/support/service-videos</a><h4>Parameters:</h4><ul><li>Flow rate: 0.001 – 300 ml/min</li><li>Maximum operating pressure: 15 MPa (2176 psi)</li><li>Flow rate setting: 0.001 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 0.5 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Communication: RS232,Ethernet (LAN),USB,Remote digital I/O</li><li>Power supply: 100 240V 50/60Hz 200VA</li><li>Dimensions W x H x D: 280 x 135 x 498 mm (11.02 x 5.12 x 18.23 in)</li><li>Weight: 13 kg (28.7 lb)</li><li>Output capillary outer diameter: 1/8”</li><li>Upper pressure limit (MPa): 1– 15 (2176PSI)</li><li>Precision of pressure measurement: ± 2%</li><li>Supported Gradient Box: ECB2005, ECB2005PC</li><li>Pressure Compensation Learning: yes&nbsp;</li></ul></div>

ECOM Separchrom PC01-HPLC Industrial Preparative Columns with Axial Compression

Separchrom PC01 ECOM industrial preparative columns correspond to the highest requirements of preparative liquid chromatography. They are designed to be used in a mode of axial compression with a moving input piston. 

<div style="display:block;" aria-labelledby="tab_item-0">HPLC Columns for prep chromatography. High performance columns with axial compression.Separchrom PC01 ECOM columns correspond to the highest requirements of preparative liquid chromatography. They are designed to be used in a mode of axial compression with a moving input piston. In the original design, they are equipped with identical pistons on input and output (biaxial compression as an option). In the ECOM Separchrom PC FE modification, they have a fixed end plate on the output instead of the piston. Pistons and plates are equipped with frits. A liquid distributing system is installed under each frit. The design guarantees perfect piston flow, high efficiency even for high injection volume, and simple accessibility of frits for cleaning. Columns can be packed by dynamic slurry method or by sedimentation or with sorbent in a dry state.SEPARCHROM PC 01 ECOM columns are made of stainless steel AISI 316L (tube inner surface is polished to reach Ra &lt; 0.3 µm) with stainless steel pistons and UHMWPE (PTFE on the request) sealing rings. The stroke of the main piston is proportional to the used hydraulic cylinder or flange bolt length. Pistons are sectional; the frit (sintered mesh disc 3 µm pore size, 5 mm thickness) with the frit ring can be removed. The output plate in the FE version is made of UHMWPE, frit is fixed with a simple frit ring. Column flanges are not welded, but screwed onto the column tube. No temperature increase during manufacturing means no change in steel properties. The column stand made of stainless steel profiles is included for columns over 100 mm I.D.Hydraulic cylinders fitted on the upper flange are offered with manual oil pumps as well as with fully automated electric motor-driven devices for column packing/unpacking procedures.<h3>Accessories</h3>Columns are offered with a broad scale of accessories such as filling adapters, slurry mixing vessels, slurry transporting pumps, etc.<h3>COLUMN CONFIGURATION EXAMPLES</h3>Columns are custom-made, do not hesitate to ask for any other sizes within the possible ranges<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_Separchrom_PC_01_HPLC_Column_available_configuration_part_1_1795482301.jpg" alt="ECOM: Separchrom PC01-HPLC Column - available configuration - part 1" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_Separchrom_PC_01_HPLC_Column_available_configuration_part_1_1795482301.jpg 236w," sizes="100vw" width="1440" height="952"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_Separchrom_PC_01_HPLC_Column_available_configuration_part_2_6d3198af67.jpg" alt="ECOM: Separchrom PC01-HPLC Column - available configuration - part 2" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_Separchrom_PC_01_HPLC_Column_available_configuration_part_2_6d3198af67.jpg 239w," sizes="100vw" width="1442" height="942"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_Separchrom_PC_01_HPLC_Column_available_configuration_part_3_9fd77a1054.jpg" alt="ECOM: Separchrom PC01-HPLC Column - available configuration - part 3" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_Separchrom_PC_01_HPLC_Column_available_configuration_part_3_9fd77a1054.jpg 245w," sizes="100vw" width="1435" height="315"></div>

ECOM Separchrom PC02-MPLC (Medium-pressure) Columns for Prep Chromatography

Industrial-scale Preparative Columns PC02 - Columns for medium-pressure with axial bed compression for prep chromatography.

<div style="display:block;" aria-labelledby="tab_item-0">ECOM Separchrom PC02 medium-pressure stainless steel columns are intended for separation where high pressure is not necessary, but good efficiency can still be expected. They are made of stainless steel tubes.Part of the column is an input piston made of ultra-high molecular weight polyethylene and it is equipped with stainless steel support and stainless steel mesh frit. Flow distributor with groves is incorporated into the piston to guarantee piston flow with nearly zero pressure drop. The design guarantees simple accessibility of frits for cleaning.Columns can be packed by dynamic slurry method, or by sedimentation, or with sorbent in the dry state, both with silica and polymer sorbents. For soft polymer sorbents, ECOM Separchrom PC02 oil systems can be equipped with a special software application to compensate for the swelling and unswelling of sorbents in different mobile phases (the column piston is moved in very small steps up and down during use).<h3>Materials</h3>Medium pressure prep chromatography column ECOM SEPARCHROM PC 02 is made of AISI 316L stainless steel, UHMWE moving pistons are equipped with integral sealing wings. Frits (stainless steel mesh 5 µm pore size, 5 mm thickness) can be fixed with a stainless steel ring. The stand made of stainless steel profiles is included.<h3>COLUMN CONFIGURATION EXAMPLES</h3>Columns are custom-made, do not hesitate to ask for any other sizes within the possible ranges<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_Separchrom_PC_02_HPLC_Column_available_configuration_part_1_dfb61faf03.jpg" alt="ECOM: Separchrom PC02-HPLC Column - available configurations - part 1" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_Separchrom_PC_02_HPLC_Column_available_configuration_part_1_dfb61faf03.jpg 245w," sizes="100vw" width="1641" height="939"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_Separchrom_PC_02_HPLC_Column_available_configuration_part_2_cb9f807757.jpg" alt="ECOM: Separchrom PC02-HPLC Column - available configurations - part 2" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_Separchrom_PC_02_HPLC_Column_available_configuration_part_2_cb9f807757.jpg 245w," sizes="100vw" width="1645" height="364"></div>

ECOM Separchrom PC04-Non-metal Columns for Prep Chromatography

Industrial-scale preparative non-metal columns for prep chromatography with axial compression correspond to the highest requirements of preparative liquid chromatography. 

<div style="display:block;" aria-labelledby="tab_item-0">Polyethylene cartridge columns are usually intended for flash chromatography. We offer powerful ECOM Separchrom PC04 columns made of high-quality ultra-high molecular weight polyethylene, equipped with moving pistons and with no metal in contact with the mobile phase. Non-metal columns are required in biochromatography and some other special applications.Plastic columns for preparative liquid chromatography ECOM SEPARCHROM PC 04, are unfilled, and made of ultra-high molecular weight polyethylene. They are equipped with the same pistons on the input and the output. The input piston is moved either by flange bolts (type A), or by a central stainless steel threaded rod (type B). The pistons are fitted with plastic polypropylene frits 10 µm and a distribution system.<h3>COLUMN CONFIGURATION EXAMPLES</h3>Columns are custom-made, do not hesitate to ask for any other sizes within the possible ranges<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ECOM_Separchrom_PC_04_HPLC_Column_available_configurations_8767eb40ae.jpg" alt="ECOM: Separchrom PC04-HPLC Column - available configurations" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ECOM_Separchrom_PC_04_HPLC_Column_available_configurations_8767eb40ae.jpg 245w," sizes="100vw" width="1645" height="823"></div>

ECOM TOY18DAD 600 H Four Channel UV/PDA Detector

Four Channel version of our detector measures at four wavelengths simultaneously with possibility to see current scan and with built-in lamp working hours counter.

<div style="display:block;" aria-labelledby="tab_item-0">TOY18DAD 600 H Four Channel UV Detector is a standalone UV-VIS detector suited for preparative and flash chromatography with diode array (DAD) in range 200 – 600 nm.Four&nbsp;Channel&nbsp;version measures at&nbsp;four wavelengths simultaneously&nbsp;with possibility to see&nbsp;current scan.More wavelengths or scan are used in liquid chromatography to verify purity of analyzed samples or in situations when some peaks absorb on different wavelengths.<h4>Most important features of TOY18DAD H detectors:</h4><ul><li>built-in lamp working hours counter</li><li>easy replacement of flow cell</li><li>measuring at more wavelengths simultaneously</li><li>sophisticated diagnostic software</li></ul><h4>Parameters:</h4><ul><li>Number of channels (Signals): 4</li><li>Scan: Informative 200 – 600 nm</li><li>Number of CCD elements: 256</li><li>Communication: RS232, Ethernet (LAN), USB</li><li>Accuracy of adjustment: ± 1 nm</li><li>Typical spectral half-width: 10 nm</li><li>Reproducibility: ± 0.5 nm</li><li>Noise (Test cell, 254nm, TC 2s, 10 Hz): ± 5 x 10-5 AU</li><li>Drift (Test cell, 254nm): 1 x 10-3 AU/hr</li><li>Time constant: Time constant (T63) 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1</li><li>Communication: RS232,Ethernet (LAN),USB</li><li>Power supply: 100-240V 50/60Hz</li><li>Power input: 100 VA (120 VA for upcoming version)</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK, KEL-F</li><li>Optical cables: no</li><li>Dimensions W x H x D: 280 x 135 x 463 mm (11.02 x 5.32 x 18.23 in)</li><li>Weight: 7.5 kg (16.53 lb)</li></ul></div>

ECOM TOY20DAD 800 H Two Channel UV/PDA Detector

Two Channel version of our detector measures at two wavelengths simultaneously with possibility to see current scan and with built-in lamp working hours counter.

<div style="display:block;" aria-labelledby="tab_item-0">TOY20DAD 800 H &nbsp;Channel UV Detector is a standalone UV-VIS detector suited for preparative and flash chromatography with diode array (DAD) in range 190 – 800 nm.Two&nbsp;Channel&nbsp;version measures at&nbsp;two wavelengths simultaneously&nbsp;with possibility to see&nbsp;current scan.More wavelengths or scan are used in liquid chromatography to verify purity of analyzed samples or in situations when some peaks absorb on different wavelengths.<h4>Most important features of TOY20DAD 800H detectors:</h4><ul><li>built-in lamp working hours counter</li><li>easy replacement of flow cell</li><li>measuring at more wavelengths simultaneously</li><li>sophisticated diagnostic software</li></ul><h4>Parameters:</h4><ul><li>Number of channels (Signals): 2</li><li>Scan: Informative 190 – 800 nm</li><li>Number of CCD elements: 256</li><li>Communication: RS232, Ethernet (LAN), USB</li><li>Accuracy of adjustment: ± 1 nm/±0.5 nm</li><li>Typical spectral half-width: 10 nm</li><li>Reproducibility: ± 0.5 nm</li><li>Noise (Test cell, 254nm, TC 2s, 10 Hz): ± 5 x 10-5 AU</li><li>Drift (Test cell, 254nm): 1 x 10-3 AU/hr</li><li>Time constant: 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1 s</li><li>Communication: RS232,Ethernet (LAN),USB</li><li>Power supply: 100-240V; 50 - 60Hz</li><li>Power input: 100 VA (120 VA for upcoming version)</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK, KEL-F</li><li>Optical cables: no</li><li>Dimensions W x H x D: 280 x 135 x 463 mm (11.02 x 5.32 x 18.23 in)</li><li>Weight: 7.5 kg (16.53 lb)&nbsp;</li></ul></div>

Products focused on PrepLC - page 3

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