We are pleased to invite you to our upcoming free online webinar on June 11, 2026 focused on one of the most pressing challenges in environmental monitoring and water quality management — PFAS (Per- and Polyfluoroalkyl Substances).As regulatory frameworks continue to evolve and compliance deadlines approach, laboratories, water utilities, and environmental professionals need robust, reliable, and cutting-edge analytical solutions to stay ahead.<blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://events.teams.microsoft.com/event/91d97003-fe33-4dca-b80b-160d9f8a5655@485ca04e-6f74-4050-9764-cdb4bfa89c25">Registration HERE</a></blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_analyzy_PFAS_a9e4a87fbc.jpg" alt="ALS: Advanced PFAS Analytical Services " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_analyzy_PFAS_a9e4a87fbc.jpg 245w," sizes="100vw" width="600" height="336"><h4>🎤 Our Speaker</h4>The webinar will be hosted by Jana Kováčová, Ph.D., PFAS Regional Lead for Continental Europe Environmental Division, who has dedicated the last several years to the field of PFAS analysis and determination in ALS laboratories. Jana is a recognized expert in PFAS environmental analytics and will share practical insights and the latest developments in analytical strategies to help your organization achieve and maintain compliance.<h4>🎯 What You Will Learn</h4><ul><li>Latest regulatory developments and compliance requirements for PFAS in water, including EU Drinking Water Directive 2020/2184 and its implications for water suppliers and laboratories.</li><li>Regulatory updates for surface water and groundwater — what's new and what to expect next.</li><li>Overview of advanced analytical strategies for PFAS detection and quantification in water matrices and how we analyse PFAS samples.</li><li>Key analytical challenges associated with PFAS testing — from ultra-trace detection to matrix interferences and contamination control.</li><li>The critical importance of using tested sampling containers and sample preservation to ensure reliable results.</li><li>Illustrative examples of results from real-world PFAS water analyses.</li><li>How ALS can support your needs with accredited PFAS testing services.</li></ul><h4>👥 Who Should Attend</h4>This webinar is designed for our clients, professionals, laboratory and technical staff, scientists, as well as anyone with an interest in analytical chemistry who wants to better understand the occurrence of these "forever chemicals" in the environment. &nbsp;<h4>💬 Q&amp;A Session</h4>There will be a live Q&amp;A session at the end of the webinar. You are welcome to submit your questions in advance during registration or ask them live on the day.<h4>📅 Additional Webinar Info:</h4><ul><li>Platform: Microsoft Teams (online)</li><li>Time: 10:00 CEST</li><li>Language: English</li><li>Duration: approx. 45 - 60 minutes (incl. Q&amp;A) Extras: If you are unable to attend on the day, please register and we will provide you with the recording of the webinar.</li></ul><h4>🔬 About ALS Environmental</h4>ALS is a global leader in environmental testing and analytical services, providing accredited PFAS analysis to clients across Europe and beyond. Our dedicated PFAS experts help clients navigate the complex regulatory landscape with confidence.<blockquote>For further information, please contact us on: marketing.cz@alsglobal.com</blockquote>We look forward to welcoming you to this important discussion on PFAS compliance in water.

Invitation to the ALS Webinar PFAS in Water 2026: Achieving Compliance through Advanced Analytical Strategies

Cells in the human body constantly evaluate signals from their surroundings and decide whether to divide, grow, or remain inactive. One of the key systems controlling this communication is the so-called Wnt signalling pathway. If this mechanism becomes disrupted, cells can spiral out of control, leading to uncontrolled growth and the development of tumours. Scientists from CEITEC and the Faculty of Science at Masaryk University have now described a critical decision-making process – the point at which a cell’s future development is decided. Their findings may, in the future, contribute to the search for ways to slow down or stop such processes in diseases like cancer.The Wnt signalling pathway is a mechanism that coordinates billions of cells in the body – it is responsible for the development of an entire organism from a single cell, and it continues to regulate tissue renewal throughout adult life. Until now, it was not fully understood how this mechanism works in detail. However, new research by teams from Masaryk University (MUNI) shows that the cells do not respond to stimuli smoothly, but rather operate in an on-off mode once a certain decision-threshold is crossed. This principle changes our understanding of how cells function together and helps explain situations in which cellular decision-making goes out of control and may lead to cancer development.The process begins at the surface of the cell, where a signal is captured by a receptor embedded in the cell membrane. A protein called Dishevelled (DVL) then binds to this receptor and carries the signal further into the cell. However, for the signal to continue, DVL must first undergo a series of chemical modifications. Small chemical groups begin to accumulate on its surface, progressively increasing its negative charge.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: New mechanism of Wnt signal transduction " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg 245w," sizes="100vw" width="1600" height="604">And this is where the decisive moment occurs.“We found that the DVL protein behaves like a switch – its structure changes abruptly once the negative charge on its surface exceeds a certain threshold. Only then does it rearrange and allow the signal to proceed further,” explains first author <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/miroslav-micka/u92423?page=publication">Miroslav Micka</a>.At this point, DVL detaches from the receptor, allowing the signal to move deeper into the cell. The cell then receives a clear instruction on how to respond – for example, to start dividing or change its function.This crucial “tipping point,” where the fate of the signal is decided, has so far been only partially understood: “Scientists knew the pathway the signal follows, but they mostly viewed it as a gradual regulatory system. However, our teams have shown that it is rather a process based on decision points and abrupt changes once a certain threshold is crossed. This is important not only for understanding how cells function, but also for explaining what happens when these processes become dysregulated,” add corresponding authors <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/konstantinos-tripsianes-ph-d/u17552?page=publication">Konstantinos Tripsianes</a> from CEITEC MUNI and <a target="_blank" rel="noopener noreferrer" href="https://www.muni.cz/en/people/11088-vitezslav-bryja">Vítězslav Bryja</a> from the Faculty of Science.Such decision points in cellular signalling are particularly important from a medical perspective, as their disruption can trigger processes that lead to tumour development. A better understanding of these processes, on the other hand, paves the way for more effective treatments.The study was published in the journal <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">Science Advances</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), enzym modifiyng DVL (red), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), enzym modifiyng DVL (red), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg 156w," sizes="100vw" width="1600" height="1600">&nbsp;<blockquote><h4>Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/β-catenin signaling</a></h4>Miroslav Micka, Jitender Kumar, Petra Paclíková, Zuzana Hayek, Kateřina Hanáková, Cherine Bechara, Hana Plešingerová, Ondrej Šedo, Sara Bologna, Elise Del Nero, Kristína Gömöryová, Vojtěch Bystrý, Tomáš Gybel, Tereza Čihalová, Marek Kravec, David Potěšil, Zbyněk Zdráhal, Konstantinos Tripsianes a Vítězslav Bryja.Sci. Adv., 2026, 12(20), eaed8899<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aed8899">DOI: 10.1126/sciadv.aed8899</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>It is well known that Dishevelled (DVL) phosphorylation by casein kinase 1 (CK1) relays Wnt signals from Frizzled (FZD) receptors to downstream effectors, yet any mechanistic aspects of DVL function related to phosphorylation remain unresolved. Here, we uncovered a Wnt-induced DVL phospho-switch that is mutually exclusive with FZD association. CK1 multiphosphorylation changes dramatically the bulk electrostatics to promote DVL intramolecular interaction between the DEP domain and the adjacent disordered region. A panel of DVL3 mutants demonstrated a switch-like behavior at the molecular level when a charge threshold was reached. Charge accumulation proximal to DEP proved to be a key functional event required, but not sufficient, for Wnt/β-catenin signaling. Proximity interactomics revealed FZD receptors as the prominent effectors of the DVL phospho-switch function consistent with the molecular competition at the DEP interface. By integrating findings at different levels, we propose a universal mechanism, in which Wnt-induced DVL conformational phospho-switch attenuates coresidence with FZDs as a means for downstream signaling events.

 Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin 

<div><div>Deoxyribozymes represent a new frontier in biotechnology. They show that DNA is much more than a storage molecule for genetic information: it can also function as a catalytic machine. Unlike traditional enzymes made of proteins, such DNA-based tools are stable, easy to produce in large quantities, and can be evolved in a lab to perform different chemical tasks we need. Their potential is vast, ranging from low-cost diagnostic kits to high-speed screening tools that can facilitate drug discovery. As our ability to understand and predict their behavior continues to improve, these versatile molecules are becoming a cornerstone for future personalized medicine and environmental monitoring.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Deoxyribozymes_tools_for_precision_sensing_and_machine_learning_guided_discoveries_e771c8c360.jpeg" alt="IOCB Prague: Deoxyribozymes, tools for precision sensing and machine learning-guided discoveries: Researchers described a new assay for DNA-editing enzymes in which the substrate in the reaction is a chemiluminescent deoxyribozyme called Supernova. ACS Chem. Biol. 2026, 21, 5, 941-950" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Deoxyribozymes_tools_for_precision_sensing_and_machine_learning_guided_discoveries_e771c8c360.jpeg 245w," sizes="100vw" width="1049" height="561"></div></div><div>Researchers led by <a target="_blank" rel="noopener noreferrer" href="https://curtis.group.uochb.cz/en">Edward Curtis</a> from IOCB Prague have developed a remarkable DNA molecule called Supernova that acts as a tiny biological flashlight, glowing blue during a specific chemical reaction. By tweaking its sequence, scientists transformed Supernova into a sensor capable of detecting DNA-editing enzymes, which are proteins that alter the sequence of DNA and are often linked to the development of cancer. These new sensors represent a step forward because they are roughly three times faster and over five times cheaper than standard assays. Depending on how they are designed, these sensors can be either "turned off" or "turned on" by a DNA-editing enzyme in a sample. Such sensors will make characterization of DNA-editing enzymes easier, and could also help scientists to find new inhibitors.<div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Deoxyribozymes_tools_for_precision_sensing_and_machine_learning_guided_discoveries_2_8e228a1903.jpeg" alt="IOCB Prague: Deoxyribozymes, tools for precision sensing and machine learning-guided discoveries: Researchers also systematically investigated the specificities of self-phosphorylating deoxyribozymes that convert the coumarin substrate 4-MUP into a fluorescent product using biochemical assays, single-step selections, and machine learning. ACS Chem. Biol. 2026, 21, 5, 951-959" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Deoxyribozymes_tools_for_precision_sensing_and_machine_learning_guided_discoveries_2_8e228a1903.jpeg 245w," sizes="100vw" width="1561" height="505">In another advance, researchers in the Curtis Group used a fluorescent deoxyribozyme named Aurora to explore how these molecular tools can be taught to recognize specific chemical targets. Using a combination of artificial evolution and machine learning, the team successfully identified specific mutations that change Aurora’s preference for one substrate over another. Machine learning is particularly powerful here because it allows researchers to predict how millions of different DNA variants will behave without having to test each one individually in a lab. This approach helps us understand the fundamental rules of how DNA molecules interact with the world, which is essential for designing more precise medicines and diagnostic tools.<h3>These results are described in two recent publications:</h3><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acschembio.5c00927">Chemiluminescent Deoxyribozyme Sensors for DNA-Editing Enzymes</a></h4>Jakubec, M.; Svoboda, M.; Kurfürst, J.; Svehlova, K.; Veverka, V.; Curtis, E. A. &nbsp;ACS Chem. Biol. 2026<a target="_blank" rel="noopener noreferrer" href="http://doi.org/10.1021/acschembio.5c00927">http://doi.org/10.1021/acschembio.5c00927</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>DNA-editing enzymes such as those in the APOBEC family of cytidine deaminases play important roles in both normal and pathogenic function, while engineered enzymes offer exciting new possibilities for genome editing. Despite their importance, widely used assays for DNA-editing enzymes are time-consuming and expensive. Here, we describe a new assay for DNA-editing enzymes in which the substrate in the reaction is a chemiluminescent deoxyribozyme called Supernova. Editing alters the sequence of Supernova, which results in a change in catalytic activity and light production. By analyzing a data set of Supernova variants previously identified by selection and high-throughput sequencing, it was possible to generate sensors with a wide range of specificities. Sensors were also developed for APOBEC3A, a cytidine deaminase which converts C to U in single-stranded DNA and RNA. These include a turn-off sensor that produces light 14-fold slower after incubation with recombinant APOBEC3A than in its absence, and a turn-on sensor that generates light 10-fold faster after incubation with APOBEC3A than in its absence. Assays that use these sensors are faster and less expensive than existing ones, and should be particularly useful for applications such as high-throughput screening.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acschembio.5c00969">Probing the Specificity of Fluorescent Deoxyribozymes Using Single-Step Selections and Machine Learning</a></h4>Král’ová, Z.; Isler, L.; Volek, M.; Jandová, M.; Kurfürst, J.; Curtis, E. A.&nbsp;ACS Chem. Biol. 2026&nbsp;<a target="_blank" rel="noopener noreferrer" href="http://doi.org/10.1021/acschembio.5c00969">http://doi.org/10.1021/acschembio.5c00969</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>The ability of proteins and nucleic acids to form specific binding sites for ligands is critical for biological function, and methods to modulate biochemical specificity are important for fields such as enzyme engineering and drug design. Here, we systematically investigated the specificities of self-phosphorylating deoxyribozymes that convert the coumarin substrate 4-MUP into a fluorescent product using biochemical assays, single-step selections, and machine learning. Activity assays using a panel of 20 catalytic motifs and 10 substrates that generate different types of signals when they are dephosphorylated revealed that these deoxyribozymes are extremely specific for 4-MUP. To identify mutations that change specificity, we constructed a library based on a self-phosphorylating fluorescent deoxyribozyme called Aurora. A series of single-step selections yielded variants that react with 4-MUP and the structurally similar substrate diFMUP, but not with the more distinct substrates pNPP and ELF. Pairwise analysis of sequences in the 4-MUP and diFMUP data sets revealed four mutations that modulate Aurora specificity. The effects of these mutations were confirmed using biochemical assays and could be predicted using models developed by machine learning. Taken together, our results show how single-step selections can be used to identify mutations that change the specificity of a deoxyribozyme. They also highlight how machine learning can be used to model complex data sets from in vitro selection experiments.</div></div>

Deoxyribozymes, tools for precision sensing and machine learning-guided discoveries

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For more than 40 years, ALS has provided testing and technical solutions to clients all over the world in a wide range of industries. We have built our global reputation by embracing the latest technologies and innovative methodologies to deliver high quality testing services to clients. ALS is able to leverage a multifaceted international team while remaining agile enough to provide local expertise and personalized solutions to every one of our clients.

ALS Czech Republic

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Phenomenex Strata X-CW Solid Phase Extraction (SPE)

Strata-X-CW weak cation-exchange SPE retains strong bases (pKa >8) with 100% organic wash for maximum cleanup. Available in tubes, 96-well plates, and giga formats.

Weak Cation Mixed-Mode Solid Phase Extraction (SPE)A weak cation-exchange functionalized polymeric sorbent that allows for complete retention of basic compounds with a pKa greater than 8, making 100% organic wash conditions possible. A 100% organic wash ensures that the maximum amount of interferences are removed from the target compound.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_CW_SPE_b16a0e0baf.jpg" alt="Phenomenex: Strata-X-CW SPE" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_CW_SPE_b16a0e0baf.jpg 245w," sizes="100vw" width="500" height="268"><ul><li>Recommended Use: Extraction of basic compounds, particularly strong bases</li></ul><h4>Starting Method</h4><h5>For Bases with pKa &gt; 8</h5><ul><li>Column: 1 mL Methanol</li><li>Equilibrate: 1 mL Water, pH 6-7</li><li>Load: Diluted Sample, pH 6-7</li><li>Wash 1: 1 mL Water, pH 6-7</li><li>Wash 2: 1 mL Methanol (collect this fraction to analyze Neutrals/Acids)</li><li>Elute Any Bases: 2x 500 µL 5 % Formic Acid in Methanol</li><li>Elute Weak Bases: 2x 500 µL 5 % NH4OH in Methanol</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_single_tube_435d45d0ad.jpg" alt="Phenomenex: Strata X single tube" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_single_tube_435d45d0ad.jpg 156w," sizes="100vw" width="1080" height="1080">Based on 30 mg/1 mL sorbent mass. The above is a convenient starting point for SPE method development, further optimization may be required to tailor the method for your specific extraction needs.<h4>Available Formats</h4><ul><li>96-Well-Plate</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_96_well_plate_9a66005814.jpg" alt="Phenomenex: Strata X 96-well plate" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_96_well_plate_9a66005814.jpg 156w," sizes="100vw" width="1080" height="1080"><ul><li>1, 3, and 6mL Tubes</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_tubes_1_9b04cab6c1.jpg" alt="Phenomenex: Strata X 1, 3, and 6mL Tubes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_tubes_1_9b04cab6c1.jpg 156w," sizes="100vw" width="1080" height="1080"><ul><li>Giga Tubes (12-150mL Tubes)</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_tubes_2_a8cd1706ec.jpg" alt="Phenomenex: Strata X Giga Tubes (12-150mL Tubes)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_tubes_2_a8cd1706ec.jpg 156w," sizes="100vw" width="1080" height="1080">

Phenomenex Strata X Solid Phase Extraction (SPE)

Strata-X reversed phase SPE retains neutrals, acids, and bases via π-π, hydrogen bonding, and hydrophobic interactions. Robust cleanup under high organic wash.

Reversed Phase Solid Phase Extraction (SPE)A reversed phase functionalized polymeric sorbent that gives strong retention of neutral, acidic, or basic compounds under aggressive, high organic wash conditions. This sorbent relies on 3 mechanisms of retention: pi-pi bonding, hydrogen bonding (dipole-dipole interactions), and hydrophobic interaction.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_d8f4451e42.jpg" alt="Phenomenex: Strata-X" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_d8f4451e42.jpg 245w," sizes="100vw" width="433" height="247"><ul><li>Recommended Use: Extraction of neutrals and aromatics</li></ul><h4>Starting Method</h4><h5>For Neutral Compounds</h5><ul><li>Column: 1 mL Methanol</li><li>Equilibrate: 1 mL Water</li><li>Load: Diluted Sample</li><li>Wash: 1 mL 5-60 % Methanol</li><li>Elute: 2x 500 µL 2 % Formic Acid in Methanol/Acetonitrile</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_single_tube_435d45d0ad.jpg" alt="Phenomenex: Strata X single tube" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_single_tube_435d45d0ad.jpg 156w," sizes="100vw" width="1080" height="1080">Based on 30 mg/1 mL sorbent mass. The above is a convenient starting point for SPE method development, further optimization may be required to tailor the method for your specific extraction needs.<h4>Available Formats</h4><ul><li>96-Well-Plate</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_96_well_plate_9a66005814.jpg" alt="Phenomenex: Strata X 96-well plate" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_96_well_plate_9a66005814.jpg 156w," sizes="100vw" width="1080" height="1080"><ul><li>1, 3, and 6mL Tubes</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_tubes_1_9b04cab6c1.jpg" alt="Phenomenex: Strata X 1, 3, and 6mL Tubes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_tubes_1_9b04cab6c1.jpg 156w," sizes="100vw" width="1080" height="1080"><ul><li>Giga Tubes (12-150mL Tubes)</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_tubes_2_a8cd1706ec.jpg" alt="Phenomenex: Strata X Giga Tubes (12-150mL Tubes)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_tubes_2_a8cd1706ec.jpg 156w," sizes="100vw" width="1080" height="1080">

Phenomenex Phree Phospholipid Removal Solutions

Phree Phospholipid Removal Solutions offer a fast effective way to remove proteins AND phospholipids from plasma samples without negatively affecting the recovery of your target analytes.

Phree Phospholipid Removal Solutions offer a fast effective way to remove proteins AND phospholipids from plasma samples without negatively affecting the recovery of your target analytes.<h5>One Quick Method, Three Big Advantages:</h5><ul><li>Remove Proteins</li><li>Eliminate Phosphopholipids,</li><li>No Method Development</li></ul><h5>A Simple 2-step Method</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phree_Phospholipid_Removal_Solutions_A_Simple_2_Step_Method_c5ef7b809c.jpg" alt="Phenomenex: Phree Phospholipid Removal Solutions - A Simple 2-Step Method" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phree_Phospholipid_Removal_Solutions_A_Simple_2_Step_Method_c5ef7b809c.jpg 245w," sizes="100vw" width="1378" height="548"><h5>How Phree Works</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phree_Phospholipid_Removal_Solutions_How_Phree_Works_eb279f0395.jpg" alt="Phenomenex: Phree Phospholipid Removal Solutions - How Phree Works" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phree_Phospholipid_Removal_Solutions_How_Phree_Works_eb279f0395.jpg 232w," sizes="100vw" width="1107" height="745">

Phenomenex Rezex RCM-Monosaccharide Ca+2 (8%) IEX HPLC Columns

Rezex RCM-Monosaccharide Ca²⁺ (8%) HPLC column (300 × 7.8 mm) enables separation of monosaccharides, sugar alcohols, and saccharides with easy regeneration and USP L19 compliance.

<h4>Key Features of the Rezex RCM-Monosaccharide Ca+2 (8%) Ion Exclusion HPLC Column:</h4><ul><li>8% cross-linked calcium</li><li>For use with monosaccharides and sugar alcohols, including sorbitol and mannitol from sweeteners and corn and cane sugars</li><li>Class separation of di-, tri-, and tetra- saccharides</li><li>Easy regeneration with calcium nitrate solutions</li><li>USP: L19</li></ul><h4>Specifications and Operating Recommendations</h4><ul><li>Part No.: 00H-0130-K0</li><li>Ionic Form: Calcium</li><li>Standard Dimensions: 300 x 7.8 mm</li><li>Matrix: Sulfonated Styrene Divinyl Benzene</li><li>Cross Linking: 8 %</li><li>Particle Size (μm): 8</li><li>Min. Efficiency (p/m) based on last peak: 35,000</li><li>Typical Pressure (psi @ Testing Flow Rate): 260</li><li>Max. Pressure (psi @ Max Flow Rate): 1,000</li><li>Max. Flow Rate (mL/min): 1.0</li><li>Max. Temperature (°C): 85</li><li>Typical Mobile Phase: Water</li><li>pH Range: Neutral</li><li>Guard Column Part: 03B-0130-K0</li></ul><h4>Cross Referencing Guide</h4><ul><li>Bio-Rad®Aminex®: HPX-87C (125-0095)</li><li>Supelco®SUPELCOGEL™: SUPELCOGEL (Ca)</li><li>Waters®Sugar-Pak™: Sugar-Pak 1</li><li>Transgenomic®CARBOSep™: CARBOSep (CHO-820)</li><li>Sepax®Carbomix®: Carbomix (Ca)</li></ul>

Phenomenex Rezex RSO-Oligosaccharide Ag+ (4%) IEX HPLC Columns

Rezex RSO-Oligosaccharide Ag⁺ (4%) is an ion-exclusion HPLC column delivering high-resolution separation of oligosaccharides up to DP18, using silver-based selectivity and a water mobile phase.

<h4>Key Features of the Rezex RSO-Oligosaccharide Ag+ (4%) Ion Exclusion HPLC Column:</h4><ul><li>4% cross-linked silver</li><li>High resolution of oligosaccharides up to 18 degrees of polymerization (Dp)</li><li>Particle Size: 12</li></ul><h4>Specifications and Operating Recommendations</h4><ul><li>Part No.: 00P-0133-N0</li><li>Ionic Form: Silver</li><li>Standard Dimensions: 200 x 10 mm</li><li>Matrix: Sulfonated Styrene Divinyl Benzene</li><li>Cross Linking: 4 %</li><li>Particle Size (μm): 12</li><li>Min. Efficiency (p/m) based on last peak: N/A</li><li>Typical Pressure (psi @ Testing Flow Rate): 115</li><li>Max. Pressure (psi @ Max Flow Rate): 300</li><li>Max. Flow Rate (mL/min): 0.3</li><li>Max. Temperature (°C): 85</li><li>Typical Mobile Phase: Water</li><li>pH Range: Neutral</li><li>Guard Column Part: 03R-0133-N0</li></ul><h4>Cleaning, Regeneration and Storage&nbsp;&nbsp;&nbsp;&nbsp; </h4><ul><li>Organic Modifiers (Max): 5 % Methanol, IPA, EtOH</li><li>Inorganic Modifiers: 5 % Silver Nitrate</li><li>Avoid: Acids, Bases, Non-Silver Salts or Metal Ions, &gt; 30 % Acetonitrile</li><li>Cleaning Solvent: 100 % Water</li><li>Flow Rate(mL/min): 0.1</li><li>Temperature (°C): 85</li><li>Duration (hrs): 12</li><li>Regeneration Solvent: 0.1 M AgNO3</li><li>Flow Rate (mL/min): 0.1</li><li>Duration (hrs): 4-16</li><li>Ship/Storage Solvent: Water</li></ul><h4>Cross Reference Guide</h4><ul><li>Bio-Rad® Aminex®: HPX-42A (125-0097)</li><li>Supelco® Supelcogel™: Supelcogel (AG1 &amp; AG2)</li><li>Waters® SugarPak™: N/A</li><li>Transgenomic® CARBOSep™: N/A</li><li>Sepax® Carbomi®: N/A</li></ul>

Phenomenex Rezex RKP-Potassium K+ (8%) IEX HPLC Columns

Rezex RKP-Potassium K⁺ (8%) is an ion-exclusion HPLC column designed for the analysis of glyphosate, using potassium form chemistry and an 8% cross-linked resin for reliable separations.

<h4>Key Features of the Rezex RKP-Potassium K+ (8%) Ion Exclusion HPLC Column:</h4><ul><li>8% cross-linked potassium</li><li>Analysis of glyphosate</li><li>Particle Size: 8</li></ul><h4>Cross Reference Guide</h4><ul><li>Bio-Rad® Aminex®: HPX-87K (125-0142)</li><li>Supelco® Supelcogel™: Supelcogel K</li><li>Waters® SugarPak™: N/A</li><li>Transgenomic® CARBOSep™: CARBOSep (COREGEL-87K)</li><li>Sepax® Carbomi®: Carbomix K</li></ul>

Phenomenex Gemini C18 HPLC Columns

Gemini C18 is a robust reversed-phase HPLC stationary phase offering unique selectivity, high structural integrity, and increased loadability, making it ideal for preparative and purification applications.

Gemini C18 HPLC phase offers unique reversed phase selectivity, high structural integrity, and increased loadability which make it ideal for preparative and purification applications in pre-packed columns and bulk media.<ul><li>Carbon Load: 14, 14 %</li><li>Surface Area (m²/g): 375</li><li>Particle Size: 3, 5, 10</li><li>Recommended Use: Separation of basic compounds under high pH conditions</li></ul><h3>Gemini HPLC Columns</h3><h4>Twin-NX technology HPLC columns. Extend your column lifetime</h4>Gemini columns are rugged reversed-phase HPLC and PREP LC columns that offer extended lifetime at pH 1-12 conditions and excellent stability for reproducible, high-efficiency separations. The Gemini family contains a variety of useful alkyl and phenyl phases bonded to fully porous organo-silica particles.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_936267c483.jpg" alt="Phenomenex: Gemini Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_936267c483.jpg 134w," sizes="100vw" width="349" height="405"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg" alt="Phenomenex: Gemini-NX Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg 134w," sizes="100vw" width="349" height="405">Each Gemini column is supplied with a Certificate of Quality Assurance (CQA) indicating testing conditions, operating parameters, and column details.

Phenomenex Gemini NX-C18 HPLC Columns

Gemini NX-C18 is a rugged, high-efficiency reversed-phase HPLC column delivering controlled selectivity for ionizable compounds and reliable performance across high and low pH LC/MS workflows.

The most rugged and highly efficient Gemini C18 HPLC column phase for reversed phase. Gemini NX-C18 takes LC/MS separations to the next level and offers:<ul><li>Control selectivity of ionizable compounds for optimized methods</li><li>Consistent performance in both volatile and non-volatile buffers</li><li>High and low pH methods</li></ul><h5>Key features:</h5><ul><li>Carbon Load:14 %</li><li>Surface Area (m²/g): 375</li><li>Particle Size: 3, 5, 10</li><li>Recommended Use: High efficiency analytical or preparative separations under extreme pH conditions</li></ul><h3>Gemini HPLC Columns</h3><h4>Twin-NX technology HPLC columns. Extend your column lifetime</h4>Gemini columns are rugged reversed-phase HPLC and PREP LC columns that offer extended lifetime at pH 1-12 conditions and excellent stability for reproducible, high-efficiency separations. The Gemini family contains a variety of useful alkyl and phenyl phases bonded to fully porous organo-silica particles.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_936267c483.jpg" alt="Phenomenex: Gemini Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_936267c483.jpg 134w," sizes="100vw" width="349" height="405"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg" alt="Phenomenex: Gemini-NX Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg 134w," sizes="100vw" width="349" height="405">Each Gemini column is supplied with a Certificate of Quality Assurance (CQA) indicating testing conditions, operating parameters, and column details.

Phenomenex Gemini C8(3) HPLC Columns

Gemini C8(3) purification media is optimized for human insulin and its analogues, offering exceptional mechanical strength, high packing efficiency, and enhanced resistance to caustic regeneration conditions.

<h4>Optimized Purification Media for Human Insulin and It's Analogues</h4><ul><li>Enhanced Robustness Against Caustic Regeneration Conditions</li><li>High Packing Efficiencies</li><li>Incredible Mechanical Strength</li></ul>Typically insulin purification methodologies include vital steps for column efficiency tests, equilibration, loading, and multiple caustic washes. In particular, the high pH caustic washes are very important for the removal aggregate build up, however these wash steps typical diminish column lifetime quite substantially. With the improved chemical robustness and performance of Gemini C8(3) customers can now switch their focus to higher yields and purities and minimize operational down-time due to less frequent need to replace contaminated media.<h4>QC Tested to ensure consistent selectivity for Insulin and Impurity</h4>In conjunction with a media designed specifically for insulin purification, the Quality team at Phenomenex strives to ensure high reproducibility of Gemini 10µm C8(3) through numerous quality control steps throughout the manufacturing process, including a fit for purpose human insulin QC test. This elevated level of focus on quality ultimately results in a model product for large scale insulin purification.<h5>Key features:</h5><ul><li>Carbon Load: -</li><li>Surface Area (m²/g): -</li><li>Particle Size: 10</li><li>Recommended Use: Separation of very hydrophobic compounds</li></ul><h3>Gemini HPLC Columns</h3><h4>Twin-NX technology HPLC columns. Extend your column lifetime</h4>Gemini columns are rugged reversed-phase HPLC and PREP LC columns that offer extended lifetime at pH 1-12 conditions and excellent stability for reproducible, high-efficiency separations. The Gemini family contains a variety of useful alkyl and phenyl phases bonded to fully porous organo-silica particles.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_936267c483.jpg" alt="Phenomenex: Gemini Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_936267c483.jpg 134w," sizes="100vw" width="349" height="405"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg" alt="Phenomenex: Gemini-NX Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg 134w," sizes="100vw" width="349" height="405">Each Gemini column is supplied with a Certificate of Quality Assurance (CQA) indicating testing conditions, operating parameters, and column details.

Phenomenex Gemini C6-Phenyl HPLC Columns

Gemini C6-Phenyl HPLC phase provides aromatic selectivity with low bleed performance, making it ideal for LC/MS analysis of aromatic, polar, and basic compounds under high pH conditions.

Gemini C6-Phenyl HPLC phase has a phenyl group bound to the organo-silica surface using a 6-carbon chain for a low bleed aromatic selective phase. Gemini C6-Phenyl is well suited for LC/MS applications.<h5>Key features:</h5><ul><li>Carbon Load: 12 %</li><li>Surface Area (m²/g): 375</li><li>Particle Size: 3, 5</li><li>Recommended Use: Separation of aromatic, polar, or basic compounds under high pH conditions</li></ul><h3>Gemini HPLC Columns</h3><h4>Twin-NX technology HPLC columns. Extend your column lifetime</h4>Gemini columns are rugged reversed-phase HPLC and PREP LC columns that offer extended lifetime at pH 1-12 conditions and excellent stability for reproducible, high-efficiency separations. The Gemini family contains a variety of useful alkyl and phenyl phases bonded to fully porous organo-silica particles.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_936267c483.jpg" alt="Phenomenex: Gemini Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_936267c483.jpg 134w," sizes="100vw" width="349" height="405"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg" alt="Phenomenex: Gemini-NX Twin Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Gemini_HPLC_Columns_2_e67e00cc54.jpg 134w," sizes="100vw" width="349" height="405">Each Gemini column is supplied with a Certificate of Quality Assurance (CQA) indicating testing conditions, operating parameters, and column details.

Products from Phenomenex - page 2

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