We are pleased to invite you to our upcoming free online webinar on June 11, 2026 focused on one of the most pressing challenges in environmental monitoring and water quality management — PFAS (Per- and Polyfluoroalkyl Substances).As regulatory frameworks continue to evolve and compliance deadlines approach, laboratories, water utilities, and environmental professionals need robust, reliable, and cutting-edge analytical solutions to stay ahead.<blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://events.teams.microsoft.com/event/91d97003-fe33-4dca-b80b-160d9f8a5655@485ca04e-6f74-4050-9764-cdb4bfa89c25">Registration HERE</a></blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_analyzy_PFAS_a9e4a87fbc.jpg" alt="ALS: Advanced PFAS Analytical Services " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_analyzy_PFAS_a9e4a87fbc.jpg 245w," sizes="100vw" width="600" height="336"><h4>🎤 Our Speaker</h4>The webinar will be hosted by Jana Kováčová, Ph.D., PFAS Regional Lead for Continental Europe Environmental Division, who has dedicated the last several years to the field of PFAS analysis and determination in ALS laboratories. Jana is a recognized expert in PFAS environmental analytics and will share practical insights and the latest developments in analytical strategies to help your organization achieve and maintain compliance.<h4>🎯 What You Will Learn</h4><ul><li>Latest regulatory developments and compliance requirements for PFAS in water, including EU Drinking Water Directive 2020/2184 and its implications for water suppliers and laboratories.</li><li>Regulatory updates for surface water and groundwater — what's new and what to expect next.</li><li>Overview of advanced analytical strategies for PFAS detection and quantification in water matrices and how we analyse PFAS samples.</li><li>Key analytical challenges associated with PFAS testing — from ultra-trace detection to matrix interferences and contamination control.</li><li>The critical importance of using tested sampling containers and sample preservation to ensure reliable results.</li><li>Illustrative examples of results from real-world PFAS water analyses.</li><li>How ALS can support your needs with accredited PFAS testing services.</li></ul><h4>👥 Who Should Attend</h4>This webinar is designed for our clients, professionals, laboratory and technical staff, scientists, as well as anyone with an interest in analytical chemistry who wants to better understand the occurrence of these "forever chemicals" in the environment. &nbsp;<h4>💬 Q&amp;A Session</h4>There will be a live Q&amp;A session at the end of the webinar. You are welcome to submit your questions in advance during registration or ask them live on the day.<h4>📅 Additional Webinar Info:</h4><ul><li>Platform: Microsoft Teams (online)</li><li>Time: 10:00 CEST</li><li>Language: English</li><li>Duration: approx. 45 - 60 minutes (incl. Q&amp;A) Extras: If you are unable to attend on the day, please register and we will provide you with the recording of the webinar.</li></ul><h4>🔬 About ALS Environmental</h4>ALS is a global leader in environmental testing and analytical services, providing accredited PFAS analysis to clients across Europe and beyond. Our dedicated PFAS experts help clients navigate the complex regulatory landscape with confidence.<blockquote>For further information, please contact us on: marketing.cz@alsglobal.com</blockquote>We look forward to welcoming you to this important discussion on PFAS compliance in water.

Invitation to the ALS Webinar PFAS in Water 2026: Achieving Compliance through Advanced Analytical Strategies

This study employs CE-ICP-MS to investigate the complexation of plutonium in oxidation states III–VI with gluconate at acidic pH, alongside analogous actinides including americium, thorium, neptunium, and uranium. Electrophoretic mobility measurements enabled characterization of complex formation and comparison of plutonium behavior with its redox analogues.The results showed similar complexation behavior for Pu(III), Pu(V), and Pu(VI) relative to corresponding actinides, while Pu(IV) exhibited distinct interactions involving mixed hydroxide–gluconate species. The findings provide new insight into actinide speciation and bonding mechanisms, demonstrating differences between tetravalent and actinyl ions and highlighting the value of CE-ICP-MS for studying radionuclide chemistry.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.5c04403">Complexation of Plutonium and Other Actinides in Different Oxidation States with Gluconate at Low pH Values─A CE-ICP-MS Study</a></h4>Janik Lohmann, Felix Sprunk, Diana Velikotrav, Alexander Wiebe, Julia Zemke, and Tobias Reich*Inorg. Chem. 2026, 65, 7, 3806–3814<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.inorgchem.5c04403">https://doi.org/10.1021/acs.inorgchem.5c04403</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.<div>Gluconic acid is considered to be one of the most important organic ligands that could influence the mobility of radionuclides in the near field of a potential low or intermediate level nuclear waste repository. <a href="javascript:void(0);">(1)</a>Through its use as a potential cement additive, gluconate can be released during cement degradation. Several studies have already demonstrated the influence of gluconate on the retention of tri- and tetravalent actinides under conditions relevant to the nuclear waste repository. <a href="javascript:void(0);">(2−6)</a> Furthermore, large quantities of sodium gluconate were introduced at the Hanford site as part of the Manhattan project. <a href="javascript:void(0);">(7)</a>Plutonium is responsible for a large part of the radiotoxicity in spent fuels. <a href="javascript:void(0);">(8)</a> Due to the complicated redox chemistry, studies with plutonium require a high degree of redox control. <a href="javascript:void(0);">(9)</a> This is probably one of the reasons that there are only a few studies with Pu, especially at low pH values. In the literature, mainly redox-stable actinides have been investigated as analogues of Pu in different oxidation states.Most studies regarding the influence of gluconate under repository-relevant conditions were conducted at alkaline or hyperalkaline pH values, which are expected during cement aging. Under the reductive conditions in the repository, actinides predominantly occur in the oxidation states +III and +IV. In literature, gluconate complexation has therefore mainly been investigated with Th(IV) <a href="javascript:void(0);">(3,5,10)</a> or U(IV) <a href="javascript:void(0);">(11)</a> as a representative of An(IV) and with Am(III), <a href="javascript:void(0);">(10)</a> Cm(III), <a href="javascript:void(0);">(6)</a> or Eu(III) <a href="javascript:void(0);">(10)</a> as representatives of An(III). For An(VI), the complexation of U(VI) <a href="javascript:void(0);">(12,13)</a> with gluconate was investigated. To our knowledge, no studies on the complexation of An(V) with GLU in an alkaline solution exist. The complexation of plutonium with GLU was only ever investigated for Pu(IV). <a href="javascript:void(0);">(5)</a> At high pH values, hydrolysis of An and the formation of mixed An–OH–GLU complexes occur. <a href="javascript:void(0);">(5,6,14)</a> Although the second pKa of gluconic acid is approximately 13 ± 1, <a href="javascript:void(0);">(15)</a> metal-induced ligand deprotonation can occur in the metal complex, resulting in the abstraction of one or more of the alcohol protons at significantly lower pH values. <a href="javascript:void(0);">(14,16,17)</a> All of these effects complicate the determination of thermodynamic data.In order to investigate mainly the binary An–GLU complexation, experiments in this work were performed at pH ≤ 4. The investigations were carried out using a combination of capillary electrophoresis (CE) and ICP-MS. In our previous work, good agreement between CE-ICP-MS and TRLFS was achieved for the Eu(III)–GLU complexation. <a href="javascript:void(0);">(14)</a>Zhang et al. systematically investigated the complexation of Nd(III), <a href="javascript:void(0);">(18)</a> Th(IV), <a href="javascript:void(0);">(7)</a> Np(V), <a href="javascript:void(0);">(19)</a> and U(VI) <a href="javascript:void(0);">(17)</a> with gluconate under similar conditions to this work using a combination of potentiometry, spectrophotometry, nuclear magnetic resonance (NMR) spectroscopy, and extended X-ray absorption fine structure (EXAFS) studies. They described the formation of binary complexes with up to three gluconate ligands for Nd(III), <a href="javascript:void(0);">(18)</a> two for Np(V), <a href="javascript:void(0);">(19)</a> and one for U(VI). <a href="javascript:void(0);">(17)</a> For Th(IV) <a href="javascript:void(0);">(7)</a> and U(VI), <a href="javascript:void(0);">(17)</a> Zhang et al. proposed the formation of hydroxyl-deprotonated gluconate complexes even at low pH values.In this work, the ability of CE-ICP-MS to measure multiple analytes simultaneously was used to confirm the desired Pu oxidation state by comparing the electrophoretic mobility with that of a redox-stable actinide. Thus, gluconate complexation was investigated for the pairs Am(III)/Pu(III) and Np(V)/Pu(V) at pH 4, U(VI)/Pu(VI) at pH 3, and Th(IV)/Pu(IV) between pH 1.3 and 2.7.<h4>2. Experimental Section</h4><h5>2.3. CE-ICP-MS</h5>All CE measurements were performed using an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=7100+CE">Agilent 7100 CE system</a> (Agilent, Santa Clara, California, USA) hyphenated to an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=7900">Agilent 7900 ICP-MS system</a> (Agilent, Santa Clara, California, USA). The coupling was realized via a MiraMist CE Nebulizer (Burgener Research, Mississauga, Canada) and a Scott-type spray chamber (AHS Analysentechnik, Tübingen, Germany). A fused silica capillary (TSP0503753, Polymicro Technologies, Phoenix, Arizona, USA) with a 50 μm inner diameter and a 50 cm length was used. A voltage of +10 kV and a pressure of 90 mbar were applied to aid the electro-osmotic flow (EOF). The temperature was kept at 25.0 ± 0.1 °C using internal air cooling of the CE device as well as a custom-built enclosure for the hyphenation.<h4>3. Results and Discussion</h4><h5>3.1. Determination of Complexation Constants</h5><h5>3.1.1. Am(III)/Pu(III) Gluconate</h5>The measured electrophoretic mobilities of Am(III) and Pu(III) at pH 4 as a function of the free gluconate concentration [GLU–] are shown in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.5c04403#fig3">Figure 3</a>. Both actinides exhibit a reduction in electrophoretic mobility with increasing gluconate concentration caused by the formation of An(III)–GLU complexes and, thus, a reduction in mean ionic charge. Under the experimental conditions, the electropherograms measured at low GLU concentrations were dominated by peaks of Pu(III) with a similar electrophoretic mobility as of Am(III) (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.inorgchem.5c04403/suppl_file/ic5c04403_si_001.pdf">Figure S7</a>, Supporting Information). With an increase in GLU concentration, peaks with neutral or negative mobilities dominated, potentially corresponding to Pu(IV)–OH–GLU species. Despite that, nearly all samples showed a peak of Pu(III) with a mobility similar to that of Am(III).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Inorg_Chem_2026_65_7_3806_3814_Figure_3_Plot_of_the_measured_electrophoretic_mobilities_15c44ffdad.jpeg" alt="Inorg. Chem. 2026, 65, 7, 3806–3814: Figure 3. Plot of the measured electrophoretic mobilities μeff of 241Am(III) and 239Pu(III) against the free gluconate concentration [GLU–] at pH 4 and I = 0.1 M (NaClO4). Fits include the 1:1 through 1:3 An(III)–GLU complexes using eq 5; R2Am(III) = 0.995 and R2Pu(III) = 0.996." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Inorg_Chem_2026_65_7_3806_3814_Figure_3_Plot_of_the_measured_electrophoretic_mobilities_15c44ffdad.jpeg 234w," sizes="100vw" width="975" height="651"><h5>3.2. Comparison of Complexation Constants</h5>The complexation of f-elements is of an electrostatic nature. <a href="javascript:void(0);">(28)</a> Ligands with the same bonding motif often follow a linear trend in complexation strength based on the effective charge zeff of the f-element. This is the case for the 1:1 acetate complexes of Pu(III), <a href="javascript:void(0);">(29)</a> Am(III), Th(IV), <a href="javascript:void(0);">(26)</a> Np(V), U(VI), <a href="javascript:void(0);">(30)</a> and Pu(VI). <a href="javascript:void(0);">(31)</a> Ca(II) <a href="javascript:void(0);">(32)</a> was added for comparison. In <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.5c04403#fig7">Figure 7</a>, log β0 is plotted against the effective charge of each metal cation, <a href="javascript:void(0);">(28)</a> exhibiting a linear trend. In general, EXAFS studies show a bidentate coordination of the acetate ligand to the actinide. <a href="javascript:void(0);">(33−36)</a><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Inorg_Chem_2026_65_7_3806_3814_Figure_7_log_v0_values_of_the_1_1_acetate_and_gluconate_complexes_plotted_against_the_effective_cationic_charge_a352d3af0d.jpeg" alt="Inorg. Chem. 2026, 65, 7, 3806–3814: Figure 7. log β0 values of the 1:1 acetate and gluconate complexes plotted against the effective cationic charge. (28) For better readability, overlapping points were shifted by zeff = ±0.02. Values determined in this work are marked by circles, values determined using CE-ICP-MS by Willberger et al. (30) and Lohmann et al. (26) are marked by diamonds and triangles, respectively, and values taken from the ThermoChimie V13a database are marked by squares (references in Table S9, Supporting Information). Gluconate complexes are red and acetate complexes are blue." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Inorg_Chem_2026_65_7_3806_3814_Figure_7_log_v0_values_of_the_1_1_acetate_and_gluconate_complexes_plotted_against_the_effective_cationic_charge_a352d3af0d.jpeg 229w," sizes="100vw" width="975" height="664">For the gluconate complexation, an interesting effect is observed. Ca(II), An(III), and Th(IV) show a linear trend with an increased complexation strength compared to acetate, while An(V) and An(IV) fall on the trend of acetate complexation. This was also noticed by Zhang et al. for U(VI). <a href="javascript:void(0);">(17)</a>An(V) and An(VI) are both present as actinyl moieties [AnO2]z+. Two covalently bonded oxygens are linearly arranged with the metal cation, which allows ligands to bind only in the equatorial plane. For An(III) and An(IV), gluconate is expected to form a stronger tridentate bond, <a href="javascript:void(0);">(7,14)</a> which seems to be sterically hindered for An(V) and An(VI). The similar complexation constants for the acetate and gluconate complexes of An(V) and An(VI) suggest a similar bidentate bonding motif through the carboxylic function of both acid anions. This is supported by the EXFAS measurements of U(VI)–GLU. <a href="javascript:void(0);">(17)</a> It has to be noted that Willberger et al. <a href="javascript:void(0);">(30)</a> determined a higher log β0 for [Am(AcO)]2+ compared to previous literature, which in turn is similar to the log β0 for [Am(GLU)]2+ determined in the present work.<h4>4. Conclusions</h4>Using the coupling between capillary electrophoresis and ICP-MS, it was possible to investigate the gluconate complexation of the major Pu oxidation states from (III) to (VI) as well as the redox stable actinides Am(III), Th(IV), Np(V), and U(VI). By addition of a redox stable actinide to the Pu sample, the oxidation state of Pu could be verified by comparing the electrophoretic mobilities. This way, the complex formation constants of three successive binary [An(GLU)x]3–x (x = 1–3) complexes could be determined for Am(III) and Pu(III). For Np(V) and Pu(V), the complex formation constants of the first binary [AnO2(GLU)](aq) complex were determined and those of the second [AnO2(GLU)2]− complex were estimated. For U(VI) and Pu(VI), the constants of the [AnO2(GLU)]+, [AnO2(GLU–H)](aq), and [AnO2(GLU–H)(GLU)]− complexes were determined. Using CE-ICP-MS, it was possible to validate/confirm previous log β0 values for the complexation of the redox analogues Np(V) and U(VI), but at much lower actinide concentrations than before, i.e., at 2 × 10–7 M. The corresponding complexation constants for Pu were determined for the first time.Plutonium in the oxidation states (III), (V), and (VI) behaved very similar to the corresponding redox analogous actinides. This was not the case for Th(IV)/Pu(IV). Here, the first five binary [Th(GLU)x]4–x (x = 1–5) complexes were determined for Th(IV), whereas mixed Pu–OH–GLU complexes were proposed for Pu. The comparison of the first complex formation constants of the An–GLU complexes suggests a different bonding motif between An3+/4+ and AnO2+/2+, with AnO2+/2+ forming the weaker complexes.</div>

Complexation of Plutonium and Other Actinides in Different Oxidation States with Gluconate at Low pH Values─A CE-ICP-MS Study

In the week of June 8, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. SCIEX: Biopharma fundamentals: Fragment analysis by CE</h5><ul><li>Tu, 9.6.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5961">Registration</a></li></ul>Join the Biopharma Fundamentals masterclass on CE-based fragment analysis and learn how CE-SDS supports reliable protein characterization and QC in regulated biopharma workflows.<h5>2. Thermo Fisher Scientific: Proteome Discoverer 3.3 SP1: Processing DIA data with DIA-NN node</h5><ul><li>Tu, 9.6.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6248">Registration</a></li></ul>Learn how to analyze DIA proteomics data using Proteome Discoverer 3.3 SP1 and the new DIA-NN node. Discover InfinDIA workflows for fast processing and large-scale proteomics studies.<h5>3. Technology Networks: Improving RNA Purity and Measurement for Reliable Bioprocessing</h5><ul><li>Tu, 9.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6229">Registration</a></li></ul>Master RNA manufacturing and analysis. Learn practical purification strategies to reduce dsRNA impurities, improve quality, and validate analytical methods for accurate RNA quantitation.<h5>4. Phenomenex: Tips for Getting the Best Out of Your LC Phenomenex Column</h5><ul><li>We, 10.6.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6237">Registration</a></li></ul>Learn how to inspect, condition, store, and maintain HPLC/UHPLC columns for maximum performance and lifetime. Discover practical troubleshooting tips and key signs that indicate column replacement.<h5>5. Waters Corporation: De-Risking LC Method Migration: Transitioning Legacy Methods to Alliance™ iS System in Regulated QC Labs</h5><ul><li>We, 10.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6244">Registration</a></li></ul>De-risk LC method migration to the Alliance iS System. Learn how automated Empower workflows preserve method intent, maintain compliance, and ensure data integrity in regulated pharmaceutical QC labs.<h5>6. C&amp;EN: New Approaches to Established Environmental IC Methods</h5><ul><li>We, 10.6.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6231">Registration</a></li></ul>Modernize environmental ion chromatography. Discover new workflows for EPA 300 A/B and perchlorate, optimize column strategies, and learn how to boost sample throughput and data quality.<h5>7. GERSTEL: An Automated Sample Preparation Platform for Integrated Proteomics, Lipidomics, and Metabolomics</h5><ul><li>We, 10.6.2026 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6232">Registration</a></li></ul>Discover an automated multi-omics sample preparation workflow using the GERSTEL MPS platform. Learn to optimize the extraction of proteins, lipids, and metabolites from a single sample for LC-MS/MS.<h5>8. ALS Czech Republic: PFAS in Water 2026: Achieving Compliance through Advanced Analytical Strategies</h5><ul><li>Th, 11.6.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6247">Registration</a></li></ul>Learn about the latest PFAS regulations, analytical challenges, and testing strategies for water analysis. Discover practical insights into compliance, sampling, and accredited PFAS workflows.<h5>9. Waters Corporation: Transform Your Daily Lab Operations with Automation - Food and Enviromental Workflows</h5><ul><li>Th, 11.6.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6233">Registration</a></li></ul>Automate routine food and environmental testing. Learn how liquid handling and SPE automation standardize sample prep in complex matrices, reduce manual workload, and secure full regulatory traceability.<h5>10. SCIEX: Pharma fundamentals: To Be or Not to Be? QQQ vs HRMS Quant</h5><ul><li>Th, 11.6.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5962">Registration</a></li></ul>Join this Pharma Fundamentals masterclass to compare sensitivity, selectivity, and workflow efficiency using SCIEX 7500+ and ZenoTOF 7600 systems.<h5>11. Bruker: MALDI Imaging at the Frontier: Spatial Metabolomics, Single-Cell Analysis, and 3D Exploration in Mixed Reality</h5><ul><li>Th, 11.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6236">Registration</a></li></ul>Discover the frontier of MALDI Imaging. Learn how spatial mass spectrometry advances single-cell analysis and 3D organoid models, transforming pharmaceutical research through mixed reality.<h5>12. SelectScience: Mass spec data digital transformation at Lilly Biologics Discovery</h5><ul><li>Th, 11.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6235">Registration</a></li></ul>Discover how digital transformation in mass spectrometry automates complex workflows, integrates labs with AI-driven models, and boosts biotech research productivity.<h5>13. Waters Corporation: How Transformative New Software Solutions Are Elevating Quality and Compliance</h5><ul><li>Th, 11.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6234">Registration</a></li></ul>Discover how cloud-based data software elevates laboratory quality and compliance. Streamline workflows, reduce operational risks, and see a live demo of innovative informatics tools.<h5>14. Thermo Fisher Scientific: Find What You’re Missing: Smarter PFAS Screening with Combustion IC + HRMS</h5><ul><li>Th, 11.6.2026 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6245">Registration</a></li></ul>Streamline PFAS screening with Combustion IC and HRMS. Combine Thermo Scientific Cindion and EFOX to detect total organic fluorine and future-proof your lab for complex environmental testing.<h5>15. Agilent Technologies: Resolving GLP-1 Impurities Using Orthogonal RPLC and HILIC Approaches</h5><ul><li>Fr, 12.6.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5946">Registration</a></li></ul>Episode 5 of Peptide 360 explores orthogonal RPLC and HILIC strategies to improve GLP-1 impurity separation, strengthen profiling confidence, and support QC and regulatory readiness.<h5>16. SelectScience: TechTalk: Clear the noise for better chromatographic separation of GLP-1 receptor agonists and insulin impurities</h5><ul><li>Fr, 12.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6246">Registration</a></li></ul>Advance GLP-1 RA and insulin impurity profiling. Discover innovative analytical tools for high-resolution, reproducible chromatographic separations without relying on suppressive mobile-phase additives.

Webinars LabRulezLCMS Week 24/2026

Article

Webinars

Video

Water

Scientific article

Science and research

For more than 40 years, ALS has provided testing and technical solutions to clients all over the world in a wide range of industries. We have built our global reputation by embracing the latest technologies and innovative methodologies to deliver high quality testing services to clients. ALS is able to leverage a multifaceted international team while remaining agile enough to provide local expertise and personalized solutions to every one of our clients.

ALS Czech Republic

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

New Food magazine

Separation Science

Agilent Technologies

Bruker

Shimadzu Corporation

The increasing popularity of extra virgin olive oil (EVOO) and the increasing problem of food fraud have provided the need for quality and authenticity control. Typical problems are the mislabeling of protected designation of origin (PDO) or edible oil adulteration. In this presentation we give an overview about the capabilities of different mass spectrometric methods to accurately determine the PDO of EVOO.
<ul>
<li>Multi-class LC-MS and GC-MS methodologies together with statistical methods enable the discrimination between different PDOs, identifying potential origin markers.</li>
<li>The combined use of non-targeted and targeted approaches enhances the outcome of the study. GC-APCI-QTOF preserves the pseudo-molecular ion information, which is a great advantage and facilitates the identification.</li>
<li>Co-eluting isomers maybe PDO markers and these can be identified and characterized by timsTOF technology.</li>
<li>Rapid LC-free, magnetic resonance mass spectrometry (MRMS) analysis was used for mapping and quality control assessment of EVOO using statistical methods which allows for clustering according to geographical origin, harvesting year, cultivation practice and the oil production procedure.</li>
</ul>
<h5>Key Topics</h5>
<ul>
<li>Introduction to food authenticity using the example of EVOO and the application of new software tools, in combination with UHPLC-QTOF and GC-APCI-QTOF, to identify origin markers.</li>
<li>Introduction into timsTOF technology and the separation of isomeric markers by timsTOF.</li>
<li>Application of LC-free, magnetic resonance mass spectrometry (MRMS) for rapid quality control assessment of extra virgin olive oil.</li>
</ul>
<h5>Who should attend?</h5>
<ul>
<li>Scientist working in the field of food research and foodomics interested in determining authenticity and/or adulteration of edible oils.</li>
<li>Scientists wishing to learn about powerful new techniques to separate isobaric isomers by mass spectroscopic techniques.</li>
</ul>
<blockquote>
Presenter: Dr. Carsten Baessmann
</blockquote>
<blockquote>
Dr. Carsten Baessmann is responsible for the development of new mass spectrometry-based solutions in the applied markets. His responsibilities include managing collaborations with leading researchers in food, environmental, forensics and clinical analysis. He is also responsible for driving the necessary hardware and software development. Dr. Baessmann holds a PhD in physical chemistry from the Technical University of Munich in the development of new mass spectrometric and laser spectroscopic methods. He has held various management positions in research and development and application development at Bruker for 22 years.
</blockquote>

Pixabay/engin akyurt: Application of new mass spectrometric methods and workflows to determine authenticity of food

Application of new mass spectrometric methods and workflows to determine authenticity of food

With the addition of MS detection to HPLC analyses, certain considerations must be made in selecting columns and conditions.
In this seminar we will:
<ul>
<li>Discuss the fundamentals and applications of various LC/MS techniques.
</li>
<li>Look at column choices and mobile phase selection for LC separations as well as for MS sensitivity
</li>
<li>Address specific challenges to LC/MS analyses, such as interferences and ion suppression, will be addressed.
</li>
<li>The importance of sample preparation in minimizing problems with interferences will also be covered.
</li>
</ul>
<blockquote>
Presenter: Mark Powell (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark Powell is an Applications Engineer located at Agilent’s Little Falls site in Wilmington, DE. Before joining Agilent in 2011, Mark worked in the pharmaceutical industry synthesizing, purifying and analyzing drug candidates. He provides applications assistance and technical support for Agilent’s HPLC columns and consumables.
</blockquote>

Agilent Technologies: Making LC Methods MS Friendly

Making LC Methods MS Friendly

With the addition of MS detection to HPLC analyses, certain considerations must be made in selecting columns and conditions.

If you’re doing food testing and want to find ways to do more with less while getting consistent accurate results this seminar is for you.
We will walk through a sample application – multi-residue pesticides in fish using LC/MS – from sample prep to data analysis, and point out tips for saving both time and money and improving results. Key topics covered will be column selection, tips for extending column life and “just enough” sample prep solutions that reduce time spent on sample prep.
<blockquote>
Presenter: Mark Powell (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark Powell is an Applications Engineer located at Agilent’s Little Falls site in Wilmington, DE. Before joining Agilent in 2011, Mark worked in the pharmaceutical industry synthesizing, purifying and analyzing drug candidates. He provides applications assistance and technical support for Agilent’s HPLC columns and consumables.
</blockquote>

Agilent Technologies: New:Troublefree Food Testing - Technologies to Improve Uptime and Productivity

Troublefree Food Testing - Technologies to Improve Uptime and Productivity

Sample application – multi-residue pesticides in fish using LC/MS.

Technologies to Improve Uptime and Productivity

High-resolution, accurate-mass (HRAM) mass spectrometers (MS) are a class of MS instrumentation with capability to resolve complex sample matrix and to allow identification of compounds by measuring their accurate masses.
In particular, those coupled to liquid chromatograph (HRAM LC/MS) have been used extensively for structural elucidation of unknown compounds primarily in chemical industry (impurity analysis) and biological researches (proteomics, metabolomics, lipidomics), but also increasingly in forensic science, food safety and environmental testing. Given the recent reduction of instrumentational cost, it will not take many more years until HRAM analysis becomes a versatile tool for all industries and researches. 
The key performance attribute underlying all application fields is mass measurement accuracy (MMA) as it affords molecular specificity and reduction of false positive results. MMA is given in the specification of HRAM instruments in parts-per-million (ppm), frequently stating a result of a set of representative measurements e.g. “&lt;1 ppm RMS”. However, this by itself does not convey how repeatably and reproducibly this MMA can be achieved. 
The webinar describes various metrics that are relevant to statistical interpretation of MMA, which explain why mass resolution of 30,000 is more than sufficient for mass measurement at sub-ppm accuracy. Using the Shimadzu LCMS-9030 quadrupole time-of-flight MS, the rationale and strength of instrument stability for consistently achieving sub-ppm MMA has been demonstrated in small molecules.
Learning objectives:
Discuss how various parameters affect the accuracy of mass measurement Demonstration of mass drift caused by temperature change Learn how to assess whether a HRAM MS is practically capable of measuring at sub-ppm mass accuracy
<blockquote>
Presenter: Atsuhiko (Ash) Toyama, PhD (MS Application Specialist, Analytical &amp; Measuring Instruments Division, Shimadzu Corporation)
</blockquote>
<blockquote>
Ash Toyama has 10 years of proteomics research experience. His areas of expertise include not only proteomics but also quantitative mass spectrometry with particular focus on bioanalysis, metabolomics and endocrinology. At Shimadzu Corporation he played roles in academic research collaborations, application development and specification development of mass spectrometers. Ash holds a Master of Science degree in Biochemistry from University of Cambridge, UK, and was granted a Ph.D. degree in Biological Sciences from University of Tokyo for his research on clinical proteomics.
</blockquote>

Shimadzu: Understand the rationale behind the Q-TOF LC/MS that stably sustains sub-ppm mass accuracy.

Understand the rationale behind the Q-TOF LC/MS that stably sustains sub-ppm mass accuracy.

Various metrics that are relevant to statistical interpretation of MMA, which explain why mass resolution of 30,000 is more than sufficient.

Understand the rationale behind the Q-TOF LC/MS

The widespread use of pesticides and the societal pressure to manufacture the purest, safest natural products mandates development of methods for precise determination of pesticide residues in botanical ingredients. Pesticide residue analysis of plant based dry ingredients used in dietary supplements is among the most difficult to perform due to complexity of the matrices.
Furthermore, implementation of a multi-residue pesticide screening program in a quality control environment can be quite difficult and time consuming. Therefore, many companies turn to specialized contract laboratories to perform such comprehensive testing. Although third party testing is commonly utilized, the in-house pesticide residue screen provides an additional layer of quality control and further ensures the safety of manufactured products.
Optimization of the critical parts of the process such as sample preparation procedure, analysis of the samples and data processing and reporting guarantees a robust and a productive workflow. At NOW Foods, two analytical platforms, GC-MS/MS and LC-MS/MS were utilized in the development of a high throughput workflow to screen a total of 500 pesticide residues in botanical matrices. Sample preparation was optimized for groups of botanical matrices and targeted towards matrix mitigation. The robustness of both platforms was evaluated over time when analyzing matrix heavy samples.
The GC-MS/MS analysis was performed on a TSQ9000 and the compound separation was optimized on a TG-5SILMS column. The LC-MS/MS analysis was performed on a TSQ Altis paired with a Vanquish LC. The chromatographic separation of the 254 compounds was achieved in 20 min. Data processing and reporting was streamlined by utilizing the Chromeleon software across both platforms.
The optimized workflow allows for a high throughput analysis of samples in a regulated quality control environment.
<h5>By attending this webinar you will learn about:</h5>
<ul>
<li>optimization of LC-MS and GC-MS workflows for pesticide analysis in food</li>
<li>techniques for extracting difficult food matrices</li>
<li>the use of Chromeleon software to streamline sample reporting</li>
</ul>
<blockquote>
Presenter: Katie Banaszewski (NOW Foods)
</blockquote>
<blockquote>
Katie Banaszewski is a Method Development Supervisor at NOW Foods, where she leads the development and validation of analytical methods. Prior to joining NOW Foods she worked at the Institute for Food Safety and Health and Mars Snackfood US. Katie specializes in mass spectrometry applications and residue analysis, and leads the development and implementation of a routine pesticide residue monitoring program at NOW Foods.
</blockquote>

Pixabay/Bruno Glätsch: Solving the Challenges and Workflow Dilemma of High-throughput Multi-residue Pesticide Screening Program in a Quality Control Environment

Solving the Challenges and Workflow Dilemma of High-throughput Multi-residue Pesticide Screening Program in a Quality Control Environment

Routine testing laboratories continue to strive for efficient and reliable sample throughput. Multiresidue pesticides is an example of this, where the generic extraction offered by QuEChERS has streamlined sample preparation. However, for comprehensive pesticide testing, both liquid and gas chromatography are typically required.
<h3>Join us to learn about:</h3>
<ul>
<li>Fit-for-purpose, comprehensive analysis of pesticides in a selection of foodstuffs, by LC- and GC-MS/MS</li>
<li>Key considerations and easy-to-use tools to maximise your method performance</li>
<li>Testing in compliance with the relevant guidelines of SANTE 11813/2017</li>
</ul>
<blockquote>
Presenter: Kari Organtini, Ph.D. (Senior Scientist, Waters Corporation)
</blockquote>
<blockquote>
Kari received her Ph.D. from Penn State studying the occurrence of dioxins and furans in fire debris. Since 2015 she has been a Senior Scientist at Waters focusing on food and environmental sample analysis.
</blockquote>

Pixabay/Jerzy Górecki: Maximizing Mass Spectrometry Capabilities in Food Analyses for Multiresidues

LCMS webinars focusing on LC/MS - page 168