Ask any analytical chemist which hyphenated technique has become indispensable over the past decade, and the answer will almost certainly be the same: tandem chromatography–mass spectrometry. Whether it is <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis">LC–MS/MS</a> quantifying a novel biologic’s metabolic fate, or <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-gc-ms/ms-analysis">GC–MS/MS</a> chasing per- and polyfluoroalkyl substances (PFAS) down to sub-part-per-trillion levels in municipal water, the combination of chromatographic separation with the specificity of tandem mass detection has become the analytical workhorse of choice across virtually every regulated sector.Below we examine the key forces propelling this expansion, from biopharma pipeline dynamics and PFAS regulatory mandates to AI-driven automation and reshoring of pharmaceutical manufacturing—and explore what each trend means for laboratories managing sample preparation and analytical workflows.<h3>Biopharma: The Engine Room of LC–MS/MS Demand</h3><h4>GLP-1 Agonists and the Metabolomics Gold Rush</h4>The explosive commercial and scientific interest in GLP-1 receptor agonists—<a target="_blank" rel="noopener noreferrer" href="https://www.sepscience.com/advancing-glp-1-peptide-analysis-chromatography-challenges-and-innovations-12163">semaglutide and related peptide therapeutics </a>for diabetes and obesity—has dramatically expanded the analytical demands placed on tandem MS platforms. Discovery programs require precise quantification of peptide drug candidates and endogenous biomarkers across complex biological matrices. These workflows rely on high-sensitivity LC–MS/MS for pharmacokinetic profiling, receptor occupancy studies, and metabolomics characterization. Metabolomics is, in fact, projected to be the fastest-growing application segment in mass spectrometry, driven in part by its growing role in cancer screening, biomarker discovery, and metabolic disease research.I have been spending more time learning about GLP-1s because this is the hot topic that people want to discuss on the Concentrating on <a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL?si=n9GLz9zjSCOrVfXPxFPhng&amp;nd=1&amp;dlsi=52868e027aad4d22">Chromatography podcast</a>. With that said, I was astounded looking at CNBC.com during breakfast this morning to see that <a target="_blank" rel="noopener noreferrer" href="https://www.cnbc.com/2026/03/21/glp-1-diets-restaurants-protein-fiber-weight-loss-drugs.html">one in eight Americans are currently taking one of these drugs such as Ozempic</a>.<h4>Antibody–Drug Conjugates and Gene Therapy: Complexity at Every Step</h4>The ascent of antibody–drug conjugates (ADCs) and gene therapies has introduced a new level of analytical complexity. ADCs blend the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads—and characterizing the linker chemistry, drug-to-antibody ratio (DAR), and conjugate stability demands high-resolution LC–MS/MS at every stage from discovery through QC release testing. Gene therapy vectors require equally rigorous characterization of impurities, aggregates, and empty/full capsid ratios.This translates into a direct need for low-evaporation, high-recovery concentration methods that preserve labile protein structures and maintain sample integrity prior to LC–MS/MS injection. <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">Nitrogen evaporation workflows</a> that minimize oxidative stress and maintain sample temperature are increasingly critical in these pipelines.<h4>Precision Medicine and Multi-Omics Integration</h4>The shift toward precision medicine has accelerated adoption of high-throughput, multi-analyte MS platforms. Proteomics, metabolomics, and lipidomics workflows are converging on a single analytical platform—tandem MS—and generating datasets of a scale and complexity that were unimaginable ten years ago.Make no mistake: the triple quadrupole serves an irreplaceable role in quantitative targeted analysis. At the same time, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3">Orbitrap </a>and Q–TOF hybrid platforms are growing rapidly as researchers demand full-scan accurate mass for untargeted discovery.<h3>Environmental Mandates: PFAS Testing Drives Adoption</h3>Environmental testing is something that every person, chemist or not, can understand the importance of. Mounting mandates from the U.S. Environmental Protection Agency and European regulators regarding PFAS—the “forever chemicals” whose extraordinary environmental persistence is matched only by the analytical challenge of detecting them at trace levels—have created immediate, compliance-driven investment in LC–MS/MS infrastructure.<h4>The Regulatory Framework Chemists Need to Know</h4>The EPA has codified a suite of LC–MS/MS-based methods as the analytical standard for PFAS in water and solid matrices:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe">EPA Method 533</a>: Weak anion exchange SPE combined with LC–MS/MS; covers 25 PFAS including short-chain compounds in drinking water.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination">EPA Method 537.1</a>: Reversed-phase SPE followed by LC–MS/MS; covers 18 PFAS including the GenX compound, with method detection limits in the low ng/L range.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/en/solutions/environmental/water-testing/pfas-in-water/us-epa-method-8327?srsltid=AfmBOooCY1pcavj7B1PH-75d3HO4BGDglNlhmyTyrpDY3zvUksMO1dlg">EPA Method 8327</a>: LC–MS/MS for selected PFAS in prepared extracts of aqueous and solid matrices.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633">EPA Draft Method 1633</a>: The emerging benchmark for PFAS in non-aqueous matrices—aqueous, solid, biosolids, and tissue—quantifying up to 40 PFAS.</li></ul>All of these methods designate LC–MS/MS, specifically LC coupled to triple quadrupole or tandem-in-time platforms operating in negative electrospray ionization mode with multiple reaction monitoring (MRM), as the required or recommended analytical technique. PFAS analysis is, at its core, an LC–MS/MS problem.<h4>The Sample Preparation Bottleneck</h4>Chemists who have worked with PFAS methods understand the particular demands they place on sample preparation. The ubiquity of<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/tackling-pfas-contamination-practical-insights-from-epa-537.1-method-development"> PFAS in laboratory materials</a>—PTFE tubing, some SPE sorbents, standard bench supplies—means that blank contamination control is as analytically demanding as the detection itself. EPA 537.1 requires that sample volumes of approximately 250 mL be extracted and reconstituted in as little as 1 mL, creating a 250:1 concentration factor that can expose even trace contamination in the sample processing chain. The installation of a delay column between the LC pump and autosampler to prevent instrument background interference is now standard practice.This is precisely where robust, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5385">inert nitrogen evaporation </a>systems earn their keep. PFAS workflows that use nitrogen-assisted evaporation to concentrate extracts prior to reconstitution benefit from materials that avoid PTFE and other fluoropolymers that can leach PFAS background—a consideration Organomation addresses in its concentration system designs.The analytical community is also moving beyond targeted PFAS analysis. High-resolution accurate mass (HRAM) spectrometry via Orbitrap technology, paired with non-targeted screening workflows, is gaining traction for the identification of the more than 5,000 currently catalogued PFAS compounds and the novel structures that continue to emerge. LC–MS/MS remains the quantitative gold standard; HRAM provides the discovery layer.<h3>Technological Trends Reshaping the LC–MS/MS Workflow</h3><h4>Artificial Intelligence and Automated Data Interpretation</h4>The datasets generated by modern tandem MS platforms—particularly in omics applications—are too large and too complex for conventional manual review. AI-driven spectral deconvolution, automated peak integration, and AI-assisted hypothesis generation are now embedded in the software suites accompanying leading instruments. <a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/about/newsroom/presrel/2022/17feb-gp22004.html?srsltid=AfmBOop3warRIaEojXM2YyMML6RXfMIDzE-Wm0h-SiKkkocBeeET2m7u">Agilent’s acquisition of Virtual Control’s ACIES </a>software specifically to automate LC–MS and GC–MS data analysis is emblematic of this direction.For laboratory managers, AI integration means smaller specialized teams can operate high-throughput multi-analyte workflows—but it also means that the front-end sample preparation must be even more reproducible, since algorithmic interpretation amplifies inconsistencies introduced upstream.<h4>Online SPE Coupling and “Chromatography Without Walls”</h4>A significant trend is the integration of solid-phase extraction directly into the HPLC flow path—so-called online SPE–HPLC coupling. Systems that combine extraction and chromatographic separation in a single analytical instrument reduce manual transfer steps, minimize the risk of sample loss or contamination, and dramatically increase throughput. For analytes at very low concentrations, online SPE provides the on-column concentration capability that traditional offline preparation achieves with manual evaporation steps.That said, offline sample preparation—including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">nitrogen-assisted evaporation</a> under controlled conditions, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2407">liquid–liquid extraction</a>, and protein precipitation—retains significant advantages in flexibility, matrix handling, and the ability to process sample volumes that exceed online system capacity. The two approaches are increasingly complementary rather than competitive in well-designed analytical laboratories.<h4>High-Purity Solvents and Reference Materials</h4>As detection limits push further into the femtogram range and regulatory methods demand demonstrable blank performance, the quality of analytical consumables—mobile phase solvents, derivatization reagents, reference standards—has moved from background consideration to front-of-mind. Method validation in regulated environments now routinely requires vendor certification of solvent purity at a level that directly interfaces with instrument performance.<h3>The Ever-Present Need for Sample Evaporation</h3>As LC–MS/MS methods push detection limits lower, the analytical burden shifts increasingly upstream. The quality of the concentration, cleanup, and reconstitution steps preceding injection determines whether the instrument’s theoretical sensitivity is achievable in practice.Several specific developments are particularly relevant:<ul><li>ADC and gene therapy characterization workflows require gentle, low-temperature evaporation that preserves protein structure and prevents aggregation prior to LC–MS/MS. Nitrogen evaporation under controlled conditions is the preferred approach.</li><li>PFAS trace analysis demands evaporation systems constructed from PFAS-inert materials, with rigorous attention to avoiding fluoropolymer surfaces throughout the sample path.</li><li>High-throughput pharmaceutical QC driven by reshoring demands parallel processing capability—multi-position evaporators that maintain consistent flow and temperature across all positions simultaneously.</li><li>Multi-omics and metabolomics workflows generate large sample batches that benefit from automated, walk-away evaporation with programmable endpoints to ensure reproducible final volumes across a cohort.</li></ul>Tandem chromatography–mass spectrometry is not merely growing; it is becoming structurally embedded in the analytical workflows of every major regulated industry. The convergence of biopharma complexity, PFAS regulatory mandates, AI-enabled data analysis, and pharmaceutical reshoring is creating a multi-year demand cycle that will require laboratories to invest not only in instruments, but in the entire sample preparation ecosystem that makes those instruments perform.For analytical chemists, the practical takeaway is this: as mass spectrometry sensitivity continues to advance, the sample preparation step becomes the binding constraint on method performance. Whether you are developing a new PFAS method to meet EPA 1633, characterizing an ADC’s drug-to-antibody ratio, or running a 500-sample metabolomics cohort overnight, the reliability and cleanliness of your concentration and cleanup workflow determines the quality of every data point that follows.&nbsp;

The Continued Rise of Tandem Chromatography–Mass Spectrometry

<h3>A Practical Guide to Getting the Most from Syringe Filters: Tips, Tricks, and Common Pitfalls</h3>Syringe filters play a crucial role in chromatography and many other laboratory applications by removing particulate matter before analysis. Proper sample filtration helps protect analytical instruments, extends column lifetime, and improves data quality. However, selecting an unsuitable filter—or using one incorrectly—can introduce contamination, reduce filtration efficiency, or even compromise analytical results. The following recommendations will help you avoid common mistakes and ensure reliable filtration every time.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp" alt="KNAUER: Avoiding Common Syringe Filter Mistakes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp 133w," sizes="100vw" width="1276" height="1496"><h4>1. Improper Filter Handling</h4>Using excessive force during filtration or attempting to reuse disposable syringe filters can damage the membrane and increase the risk of sample contamination.<ul><li>Solution: Apply slow, even pressure throughout the filtration process and always dispose of single-use filters after one use. If the flow rate decreases noticeably, replace the filter instead of applying additional force.</li></ul><h4>2. Selecting an Inappropriate Pore Size</h4>Using the wrong pore size may either fail to remove unwanted particles or cause the membrane to clog prematurely, reducing filtration efficiency.<ul><li>Solution: A 0.45 µm membrane is generally suitable for routine particulate removal, while a 0.22 µm membrane is recommended for finer filtration and bacterial removal. Samples with higher viscosity may require a pre-filter to prevent rapid clogging. It is also important to consider the intended analytical technique. For example, 0.22 µm filters are typically preferred for UHPLC and LC-MS applications, whereas 0.45 µm filters are often sufficient for conventional HPLC analyses.</li></ul><h4>3. Choosing the Wrong Membrane Material</h4>Different membrane materials exhibit different chemical resistance. Using an incompatible membrane may lead to degradation of the filter, sample contamination, or complete filtration failure.<ul><li>Solution: Always verify solvent compatibility before filtration. PTFE membranes are an excellent choice for organic solvents, while PES and nylon membranes are better suited to aqueous samples. If compatibility is uncertain, perform a small-scale trial before filtering valuable samples.</li><li>Pro Tip: For additional guidance, see our blog article "How to Choose the Right Membrane for your Syringe Filter", which provides a detailed comparison of membrane materials and their recommended applications.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg" alt="KNAUER Sepapure® Syringe Filters are available with multiple membrane materials, each identified by a dedicated color code for quick and reliable selection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg 245w," sizes="100vw" width="1580" height="902"><h4>4. Ignoring Filter Capacity</h4>Using a filter with insufficient capacity can result in rapid membrane blockage, increasing filtration time and reducing laboratory productivity.<ul><li>Solution: When filtering larger sample volumes, choose high-capacity syringe filters or introduce a pre-filtration step. Never force liquid through a clogged membrane, as doing so may damage the filter and negatively affect sample quality.</li></ul><h4>5. Overlooking Sample Adsorption</h4>Certain membrane materials may adsorb analytes of interest, leading to lower recoveries and potentially affecting quantitative results.<ul><li>Solution: For protein samples or other adsorption-sensitive analytes, select membranes with low binding characteristics, such as nylon or glass fiber, whenever appropriate. Performing a small recovery test before routine analysis can help identify potential analyte losses.</li></ul><h4>6. Failing to Optimize Filtration Performance</h4>Slow filtration is more than just an inconvenience—it often indicates that the filtration conditions are not optimal.<ul><li>Solution: If filtration becomes unusually slow, investigate possible causes such as membrane clogging, excessive sample viscosity, or an unnecessarily small pore size. Depending on the sample, dilution or sequential filtration using progressively finer filters may significantly improve performance.</li></ul><h4>Final Thoughts</h4>Selecting the appropriate syringe filter is a straightforward process, but overlooking small details can have a significant impact on analytical performance. Choosing the correct membrane material, pore size, and filtration strategy helps improve laboratory efficiency, protects chromatography systems and columns, and contributes to accurate, reproducible analytical results.With the right syringe filter and proper filtration technique, you can minimize sample preparation problems and maximize confidence in every analysis.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg" alt="KNAUER: Sepapure® Syringe Filter Selection" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg 245w," sizes="100vw" width="1160" height="627">Happy filtering!

Avoiding Common Syringe Filter Mistakes

News from LabRulezLCMS Library - Week 27, 2026

Article

Product

Application

Academy

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Separation Science

Agilent Technologies

Thermo Fisher Scientific

SelectScience

SciY/Mestrelab Research

Waters Corporation

Accelerating Routine Food &amp; Beverage Testing with Optimized Methods
Explore the latest technology and methodology solutions to help you deliver results more easily and efficiently for routine Food and Beverage QC testing for : Sugars, Sugar Substitutes Additives, Vitamins and Amino Acids.
<h3>EPISODE 2 - Sugar Additives Analysis</h3>
<h3>Agenda</h3>
<h4>Developing Efficient Methodologies for Sugar Substitute Analysis</h4>
<ul>
<li>Presenter: Dr. Jinchuan Tran (Principal Scientist - Waters​)</li>
</ul>
Sugar taxes and consumer demand for sugar-free versions of popular beverage brands have seen a continued increase in the development of diet and zero sugar products. Analyzing sugar substitutes and other ingredients in food and beverages is an important assay to ensure a product is within specification. The concentration and combination of different sweeteners in beverages are key to a product’s characteristic flavor and need to be consistent wherever the product is manufactured. In this talk, we will explore how Waters separation technologies can support the development of efficient methodologies for the routine analysis of sugar
<h4>Increase your laboratory efficiency with Empower</h4>
Speaker: to be announced
Abstract: Increase your laboratory efficiency with Empower. Learn how Empower&#39;s system suitability checks and custom calculation fields can help streamline food and beverage testing. Ensure system readiness, simplify workflows, and eliminate transcription errors.
Three methods of sweeteners: Steviol, Acesulfame, and Sucralose on soda and tea matrices
<ul>
<li>Presenter: to be announced</li>
</ul>
Abstract: Available soon
<h5>Live Q&amp;A session</h5>
<ul>
<li>Moderator: Cecile Pinto (Food &amp; Environmental Market Development Manager, South Europe - Waters)
</li>
<li>Speaker: Dr. Jinchuan Yang (Principal Scientist - Waters)
</li>
</ul>
<blockquote>
Presenter: Dr. Jinchuan Yang (Principal Scientist, Scientific Operations, Waters Corporation)
</blockquote>
<blockquote>
Dr. Jinchuan Yang is a principal scientist in the Scientific Operations at Waters Corporation. Since he joined Waters in 2002, his roles at Waters have mainly focused on application development, marketing development, as well as support for R&amp;D and training. His main technical expertise is in the food and the environmental analysis areas as well as in material characterization. He volunteers in technical groups at AOAC International and USP and serves as a member of expert panels in these organizations.
</blockquote>

Waters Corporation: Analysis of Sugar Substitutes in Food and Beverages​

Analysis of Sugar Substitutes in Food and Beverages​

Topics: Developing Efficient Methodologies for Sugar Substitute Analysi; Increase your laboratory efficiency with Empower.

The scientific experience is critical to the success and efficiency of the entire laboratory ecosystem – from software and instruments to workflows and processes. Scientists need to be able to focus on their critical work, and not be burdened by challenges such as siloed data, manual processes, and old technology. It is critical that organizations keep pace with technological and scientific advancements, as those changes have a direct impact on how a lab operates.
The way that laboratory personnel need to interact with software, instruments, equipment, and systems makes a significant impact on their daily work. Access to mobile applications, barcode-driven workflows, voice control capabilities, and extended reality software provides innovative and easier ways for scientists to achieve their goals. New automation capabilities improve efficiency, eliminating manual intervention and streamlining processes and workflows in the lab. Improved tools, such as enhanced dashboards and new AI/ML capabilities, deliver knowledge from data and empower the scientist to make faster, more informed decisions. Lab software solutions built with pre-configured QA/QC capabilities provide an intuitive, easy process to execute typical scientific workflows with minimal training.
<h5>By attending this presentation you will learn about:</h5>
<ul>
<li>Novel ways to interact with LIMS - Mobile, barcode driven workflows, voice control, and extended reality</li>
<li>Delivering knowledge from data – Dashboards and data analytics, including AI/ML capabilities</li>
<li>Automation solutions - Drive Business Intelligence, eliminate manual intervention, and improve efficiency</li>
<li>Intuitive workflows – Easier, more simplified processes with pre-configured QA/QC capabilities</li>
</ul>
<blockquote>
Presenter: Nicola Gardner (Senior Manager, Product Marketing – Digital Science Solutions, Thermo Fisher Scientific)
</blockquote>
<blockquote>
As Sr. Manager, Product Marketing for the Digital Science Solutions business at Thermo Fisher Scientific, Nicola leads the marketing strategy around our product portfolio, and describes to customers how they can apply laboratory software to move towards a smarter lab and digitally transform their business. A Masters in Analytical Chemistry and a wealth of laboratory experience provides Nicola with a solid understanding of process, data, and connectivity challenges. Nicola helps to drive discussion around technology adoption to inform businesses on their digital transformation journey and to enable scientists to spend more time focusing on science.
</blockquote>

Pixabay/Photo Mix: Enhancing the scientific experience using laboratory software

Enhancing the scientific experience using laboratory software

Novel ways to interact with LIMS. Delivering knowledge from data. Automation solutions. Intuitive workflows.

The scientific experience using laboratory software

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
SureMass, a novel data format for high resolution mass analyzers, offers better analysis speed and mass accuracy - even for high concentration or complex samples. This data format is derived from profile data and adapts to changes in experimental conditions to enhance obscured peaks, extend linear dynamic range, improve batch analysis speeds, and maintain trace detection with repeatability. These SureMass capabilities allow users to view quality peaks, fast and with accuracy. In this webinar SureMass conversion will be shown and examples of its speed and improved mass accuracy will be shared.
<blockquote>
Presenter: Cathyrin Simmermaker (LC/MS Applications Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Cate Simmermaker is an LC/MS Applications Engineer with Agilent Technologies working primarily with high-resolution mass spectrometry in small molecule analysis. Cate has worked in applications including metabolomics, food safety, and forensics on Q-TOF and QQQ platforms. She is currently pursuing her PhD in Chemistry from the University of the Pacific and received a Master’s in Biochemistry from San Francisco State University.
</blockquote>

Agilent Technologies: SureMass: Fast, Accurate, and Reproducible Data Processing

SureMass: Fast, Accurate, and Reproducible Data Processing

In this webinar SureMass conversion will be shown and examples of its speed and improved mass accuracy will be shared.

Accelerating Routine Food &amp; Beverage Testing with Optimized Methods
Explore the latest technology and methodology solutions to help you deliver results more easily and efficiently for routine Food and Beverage QC testing for : Sugars, Sugar Substitutes Additives, Vitamins and Amino Acids.
<h3>EPISODE 2 - Sugar Additives Analysis</h3>
<h5>Developing Efficient Methodologies for Sugar Substitute Analysis</h5>
<ul>
<li>Presenter: Carsten Fischer, Ph.D. (Principal Technical Specialist Informatics Product Marketing EMEA - Waters)</li>
</ul>
Sugar taxes and consumer demand for sugar-free versions of popular beverage brands have seen a continued increase in the development of diet and zero sugar products. The concentration and combination of different sweeteners in beverages are key to a product’s characteristic flavor and need to be consistent wherever the product is manufactured. Analyzing sugar substitutes and other ingredients in food and beverages is an important assay to ensure a product is within specification. In this talk, we will explore how Waters separation technologies can support the routine analysis of sweeteners and other ingredients in beverages to ensure high and consistent quality of products.
<h5>Increase your laboratory efficiency with Empower</h5>
<ul>
<li>Presenter: Carsten Fischer, Ph.D. (Principal Technical Specialist Informatics Product Marketing EMEA - Waters)</li>
</ul>
Increase your laboratory efficiency with Empower. Learn how Empower&#39;s system suitability checks and custom calculation fields can help streamline food and beverage testing. Ensure system readiness, simplify workflows, and eliminate transcription errors.
<h5>Three methods of sweeteners: Steviol, Acesulfame, and Sucralose on soda and tea matrices</h5>
<ul>
<li>Presenter: Marie-Laure Riandiere (Laboratory Manager - Antartic)</li>
</ul>
We are pleased to receive a special guest Marie-Laure Riandière from the company Antartic SAS, Mousquetaires group. A great thanks for their participation and collaboration to share their quality control expertise in our webinar. Marie-Laure Riandière and her team will be pleased to present their QC analysis of different sweeteners in beverages with HPLC systems and give some highlights on their methods , and chromatograms examples on various matrices.
<h5>Live Q&amp;A session</h5>
<ul>
<li>Moderator: Cecile Pinto (Food &amp; Environmental Market Development Manage, South Europe - Waters)
</li>
<li>Presenter: Carsten Fischer, Ph.D. (Principal Technical Specialist Informatics Product Marketing EMEA - Waters)
</li>
<li>Presenter: Carsten Fischer, Ph.D. (Principal Technical Specialist Informatics Product Marketing EMEA - Waters)
</li>
<li>Presenter: Marie-Laure Riandiere (Laboratory Manager - Antartic)
</li>
</ul>
<blockquote>
Presenter: Dr. Jinchuan Yang (Principal Scientist, Scientific Operations, Waters Corporation)
</blockquote>
<blockquote>
Dr. Jinchuan Yang is a principal scientist in the Scientific Operations at Waters Corporation. Since he joined Waters in 2002, his roles at Waters have mainly focused on application development, marketing development, as well as support for R&amp;D and training. His main technical expertise is in the food and the environmental analysis areas as well as in material characterization. He volunteers in technical groups at AOAC International and USP and serves as a member of expert panels in these organizations.
</blockquote>
<blockquote>
Presenter: Carsten Fischer, Ph.D. (Principal Technical Specialist Informatics Product Marketing, EMEA, Waters)
</blockquote>
<blockquote>
Carsten Fischer, Ph.D., joined Waters in 2004. After a number of years in the Empower data support group, in business development and in informatics sales, his current role is principal technical specialist in the informatics product marketing group for the EMEA region. He provides internal support for Empower CDS Software and is focused on enterprise informatics, compliance, and data science.
</blockquote>
<blockquote>
Presenter: Marie-Laure Riandiere (Laboratory Manager, Antartic SAS)
</blockquote>
<blockquote>
Marie-Laure Riandiere joined Antartic SAS in 1990 and is Laboratory Manager since 2015
</blockquote>

Developing Efficient Methodologies for Sugar Substitute Analysis. Laboratory efficiency with Empower. Three methods of sweeteners...

How about a 20 minute coffee break along with a bite of Empower? Here you go!
Increase the resilience of your lab operations with the Empower™ Business Continuity (BC) LAC/E™ &amp; SecureSync™.
Disaster Recovery and Business Continuity are theoretical exercises…until they aren’t.
Prepare a coffee and join!
<blockquote>
Presenter: Carsten Fischer (Informatics Product Marketing Manager·Waters Corporation)
</blockquote>
<blockquote>
Experienced Business Development Manager with a demonstrated history of working in the Research Industry. Skilled in Chemistry, Life Sciences, Strategic Planning, and Laboratory Informatics. 
</blockquote>

Waters Corporation: Empower Business Continuity (BC) LAC/E & SecureSync

Empower Business Continuity (BC) LAC/E & SecureSync

Complement your #Empower CDS with sample management, equipment inventory and data archiving.

Digital transformation is a journey driven by the desire to fundamentally improve laboratory working practices by leveraging the latest advances in technology. Whether it be a need to eliminate errors, operate more efficiently, or reach confident results faster, laboratories are focusing more than ever on software.
Designed as a scalable solution for modern, dynamic (often cloud-based) environments, the Thermo Scientific™ Ardia™ Platform brings together chromatography and mass spectrometry, connecting data and instruments, helping scientists get closer to the truth. In this webinar, discover how you can reap the benefits of a connected platform to maximize instrument utilization, streamline lab and data management, and realize true efficiency gains.
Key learning objectives
<ul>
<li>Discover how you can enable wider collaboration within your business</li>
<li>Learn how you can access, monitor and schedule instruments from a single location</li>
<li>Find out how you simplify data storage and expedite review</li>
</ul>
Who should attend?
<ul>
<li>Lab managers</li>
<li>Principle scientists</li>
<li>Technical specialists</li>
<li>MS users</li>
<li>IT managers</li>
</ul>
<blockquote>
Presenter: Peter Zipfell (Product Marketing Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
For the past 22 years, Peter Zipfell has worked extensively with chromatography hardware and software transitioning from LC-MS method development through HPLC technical support to chromatography data systems. He joined Thermo Fisher Scientific over 13 years ago and more recently became involved as the lead for Ardia platform product marketing. His focus has always been to support Thermo Fisher customers by delivering software solutions across multiple industries to enable them to improve their current workflows and increase productivity.
</blockquote>
<blockquote>
Presenter: Kevin Schauer (Product Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Kevin Schauer is a molecular biologist by training and has been working with chromatography and mass spectrometry instrumentation for over 10 years. He joined Thermo Fisher Scientific five years ago as a field applications scientist where he worked with customers to better leverage the capabilities of the mass spectrometry instrumentation for their life science research. He transitioned to the Ardia platform product management team several years ago where he now works to produce software that allows users to operate more efficiently and get their work done faster.
</blockquote>
<blockquote>
Presenter: Georgina Wynne Hughes (Editorial Team, SelectScience)
</blockquote>
<blockquote>
Georgina studied at Birmingham University where she gained a BSc in Biomedical Science, and an MSc by Research in Cancer and Genomic Sciences, which focused on defective autophagy in rare neurodegenerative diseases. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Take control of your data and instruments: Your journey starts here

Take control of your data and instruments: Your journey starts here

The Thermo Scientific Ardia Platform brings together chromatography and mass spectrometry, connecting data and instruments.

Take control of your data and instruments: Your journey

This webinar will cover the analysis of pesticides in food and highlight the productivity enhancement features available on Thermo Scientific chromatography systems.
We will look at the analysis of pesticides using GC-MS/MS with helium conservation and the use of alternative carrier gas to ensure sustainable productivity. 
Our experts will show how single software platform can optimize your pesticides analysis and drive efficiency in your laboratory for GC-, LC-, IC-, MS/MS analysis.
Dual sequence processing, where data can be merged to provide orthogonal cross confirmation of identity and increased confidence in results will be discussed.
It will also be demonstrated how the software supports SANTE analytical quality control criteria for compliant analysis.
<blockquote>
Presenter: Łukasz Rajski (Product Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Łukasz Rajski works as product application specialist at Thermo Fisher Scientific. He holds a Ph.D. in analytical chemistry. Łukasz has over 10 years of experience in pesticide residue analysis. He is an expert in the development and validation of analytical methods. Dr. Rajski works with advanced mass spectrometry techniques (both high-resolution and triple quadrupole) coupled to ultra-high performance liquid chromatography, high-performance ion chromatography, and gas chromatography. Łukasz Rajski is a co-author of numerous articles published in scientific journals with high impact factor and book chapters dedicated to pesticide residue analysis
</blockquote>
<blockquote>
Presenter: Zoe Julian (Product Marketing Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Zoe Julian is a product marketing manager for chromatography software within the CMD Software team at Thermo Fisher Scientific. With over 12 years&#39; experience of working with chromatography and mass spectrometry techniques with a background in GC and GC-MS(/MS) organic environmental analysis, she has helped many laboratories and industries improve their workflows through a unique understanding of their challenges. Transitioning to a focus on Thermo Scientific™ Chromeleon™ CDS, she has shown customers how software solutions can improve their productivity and support their day-to-day operations.
</blockquote>

Pixabay/DanaTentis: Sustainable productive pesticide analysis

Sustainable productive pesticide analysis

This webinar will cover the analysis of pesticides in food and highlight the productivity enhancement features available on chromatography systems.

Robustness testing is a measure of a method’s ability to remain unaffected by the minor changes of chromatographic parameters. The robustness multivariable design of experiments (DoE) can be used to study the effect of individual parameters and their interaction on the chromatographic resolution between peaks.
The Empower Sample Set Generator (SSG) can be used to automatically create a sample set method, which includes instrument methods, and method sets required to perform the entire study in one run. The Effect Plots generated by the Method Validation Manager clearly show which parameters have the greatest effect on method performance and provides knowledge for establishing a set of controls to assure a method meets the expected criteria during routine use.
Key points of discussion will be:
<ul>
<li>Using the Sample Set Generator with the Method Validation Manager option to easily create Sample Sets needed for the Robustness test
</li>
<li>The Robustness multivariable design of Experiments (DoE) is easily created to study the effect of parameters and their interaction on chromatographic resolution between peaks
</li>
<li>The Effect Plot in the Report Publisher can be used to clearly shows which parameters have the greatest effect on method performance
</li>
</ul>
Join us for a live discussion as we explore Empower 3.8.0. As always, don’t forget to bring your questions for this exclusive opportunity to ask our experts anything about Empower Software
<blockquote>
Presenter: Neil Lander (Principal Product Manager, Waters Corporation)
</blockquote>
<blockquote>
Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.
</blockquote>

Waters Corporation: Smart Method Development using the Empower Method Validation Manager and the Sample Set Generator

Smart Method Development using the Empower Method Validation Manager and the Sample Set Generator

Using the Sample Set Generator with the Method Validation Manager option to easily create Sample Sets needed for the Robustness test.

Smart Method Development using the Empower Method Validation

Agilent&#39;s Cary 3500 Flexible UV-VIS Spectrometer provides the accuracy and reliability needed for meeting compliance standards.
This presentation will discuss an overview of the instrument&#39;s newest functions as well as the software&#39;s ability to maintain data integrity through Agilent&#39;s OpenLab Platform.
<blockquote>
Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
</blockquote>

Agilent Technologies: Meeting 21 CFR 11 Compliance with the Cary 3500 Flexible UV-VIS Spectrometer

Meeting 21 CFR 11 Compliance with the Cary 3500 Flexible UV-VIS Spectrometer

We will discuss an overview of the instrument's newest functions as well as the software's ability.

Meeting 21 CFR 11 Compliance with the Cary 3500 UV-VIS

<h4>Intro</h4>
Mnova MSChrom is a vendor agnostic desktop application for review, processing, analysis, and interrogation of LC/MS data.
<h4>Overview</h4>
Mnova MSChrom brings expert tools to the desktop user, with game changing enhancements in peak picking, spectral display, and spectral subtraction.
<h4>What to expect</h4>
<ul>
<li>Introduction of the new ‘enhanced peak picking’ algorithm</li>
<li>Instantly display the information you want to see, how you want to see it – MS Navigator</li>
<li>Subtract the background or any signal from your LC/MS experiment</li>
<li>Search and compare MS database hits</li>
<li>Automate meta-analysis, databasing, reporting with Mnova Gears</li>
</ul>
<h4>Key points</h4>
<ul>
<li>Updated functionality – Mnova MSChrom is a competitive desktop application for LC/MS</li>
<li>Extensibility – Mestrelab Research provides scripting, API and automation for heterogeneous and high throughput laboratories</li>
<li>Continuous improvement – committed to developing the capabilities that you desire</li>
</ul>
<h4>Who should attend?</h4>
Those using hyphenated MS techniques, especially LC/MS with a need to review, process and analyze data away from the instrument.
<blockquote>
Presenter: Gavin Shear (Business Development Manager, Mestrelab)
</blockquote>
<blockquote>
Gavin brings over 20 years of experience in the software industry, including previous work with SCIEX as a Mass Spectrometry test lead, also as senior applications scientist for a major cheminformatics company.
</blockquote>
<blockquote>
Gavin received his Honours degree in Chemistry at the University of Waterloo in Canada. After graduation, he experienced life as a Chemist in several industries including pharmaceutical analysis, agricultural research and oil additives. Notably, Gavin incepted the Applications Science team at ACD//Labs helping to connect scientists to emerging technologies such as computer aided structure elucidation, and high throughput laboratory automation. After a 4 year stint at mass spectrometry manufacturer SCIEX, he joins Mestrelab Research with a wealth of practical experience and enthusiasm for his work. In his spare time, Gavin is a semi-professional musician, playing several instruments, including guitars, woodwinds, and brass.
</blockquote>

Mestrelab Research: Advances in Processing and Analysis of Hyphenated MS Experiments

Advances in Processing and Analysis of Hyphenated MS Experiments

Description of expert tools with game changing enhancements in peak picking, spectral display, and spectral substraction using Mnova MSChrom.

LCMS webinars focusing on Software - page 34

Meeting 21 CFR 11 Compliance with the Cary 3500 Flexible UV-VIS Spectrometer

Smart Method Development using the Empower Method Validation Manager and the Sample Set Generator

SureMass: Fast, Accurate, and Reproducible Data Processing

Take control of your data and instruments: Your journey starts here

Sustainable productive pesticide analysis

Advances in Processing and Analysis of Hyphenated MS Experiments

Analysis of Sugar Substitutes in Food and Beverages

Analysis of Sugar Substitutes in Food and Beverages

Empower Business Continuity (BC) LAC/E & SecureSync

Enhancing the scientific experience using laboratory software

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LCMS webinars focusing on Software - page 34

Meeting 21 CFR 11 Compliance with the Cary 3500 Flexible UV-VIS Spectrometer

Smart Method Development using the Empower Method Validation Manager and the Sample Set Generator

SureMass: Fast, Accurate, and Reproducible Data Processing

Take control of your data and instruments: Your journey starts here

Sustainable productive pesticide analysis

Advances in Processing and Analysis of Hyphenated MS Experiments

Analysis of Sugar Substitutes in Food and Beverages​

Analysis of Sugar Substitutes in Food and Beverages​

Empower Business Continuity (BC) LAC/E & SecureSync

Enhancing the scientific experience using laboratory software

Related content

The Continued Rise of Tandem Chromatography–Mass Spectrometry

News from LabRulezLCMS Library - Week 27, 2026

Avoiding Common Syringe Filter Mistakes

Analysis of Sugar Substitutes in Food and Beverages

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