<div>Mulching films used in agriculture gradually break down and can become a significant source of microplastics in soils. A new study shows that these particles affect not only soil structure but also microbial life and nitrogen cycling.“We wanted to understand how microplastics from both conventional and biodegradable mulching films influence soil properties, microbial diversity and functions in real conditions,” explains Klára Šmídová, the study’s co-author . “That’s why we added realistic amounts of microplastics to soils in experimental plots in Finland, Germany, and Spain, monitored them over two growing seasons, and compared them with the control plots.”The results revealed that microplastics alter soil characteristics and microbial communities, although not always in the same way. “ However, a consistent finding was the decline in microbial activity associated with key processes, including nitrogen cycling, with negative effects increasing at higher microplastic concentrations and becoming more pronounced in the second year,” Šmídová adds. Because the microplastic levels used in the study reflect amounts already found in European soils, the findings highlight real risks to soil health. “We also found that the effects were stronger in southern than in northern Europe, likely due to differences in climate and soil conditions. This means that protecting soils from plastic pollution will require region-specific risk assessments,” she says.Over 60% of European soils are estimated to be unhealthy, with ongoing degradation driven by unsustainable land use, contamination, climate change, and extreme weather events. In response, the EU Parliament adopted the Soil Monitoring Law in October 2025, aiming to achieve healthy soils across Europe by 2050. “The law highlights the role of soil health in food security, water quality, and climate objectives, and establishes consistent soil monitoring across Member States. It includes measures to support farmers and foresters, while also creating a public list of potentially contaminated sites and an indicative watch list of emerging soil contaminants,” explains Klára Šmídová.The project brought together 19 research groups across Europe. “After each season, hundreds of samples were colle cted and sent to partners for analysis. This paper focuses on soil properties, microbial diversity, and greenhouse gas emissions. Two more manuscripts—on plastic additives and microplastic fate, and on soil invertebrates—are in preparation. Together, they will give us a complete picture of how agricultural microplastics affect soil ecosystems,” concludes Klára Šmídová.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg" alt="RECETOX: New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg 171w," sizes="100vw" width="738" height="674"><blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0269749125015866?via%3Dihub#sec2">Conventional and biodegradable agricultural microplastics: effects on soil properties and microbial functions across a European pedoclimatic gradient</a></h4>Šmídová K., Soinne H., Kim S. W., Tirronniemi J., Meffe R., Redondo-Hasselerharm P. E., Braun M., Rillig M. C., Fritze H., Adamczyk B., Nikama J., Kaseva J., Saartama V., Amelung W., Hurley R., Hofman J., Nizzetto L., Selonen S., Velmala S.Environ. Pollut. 386 (2025) 127212<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.envpol.2025.127212">10.1016/j.envpol.2025.127212</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4><div>Agricultural plastics like mulching films may become a major source of microplastic (MP) soil contamination during their degradation and fragmentation. This study investigates the effects of agricultural MPs from conventional (linear low-density polyethylene, PE) and biodegradable (starch-blended polybutylene adipate co-terephthalate, PBAT-BD) mulching films on soil physicochemical properties, aggregation, microbial diversity and functions, litter decomposition, and greenhouse gases emissions (GHG). For this purpose, MPs were mixed into soils at realistic MP concentrations of 0.005&nbsp;% and 0.05&nbsp;% (w/w) in 2022 on experimental plots in three EU countries representing different pedoclimatic conditions (Finland, Germany and Spain), followed by monitoring of the above-mentioned variables in the subsequent growing seasons 2022 and 2023. We found several significant MP-induced effects for soil properties, aggregation, microbial diversity, litter decomposition, and GHG, but the effect endpoints were less pronounced or varied considerably. Contrarily, microbial activity, contributing to soil functions such as nitrogen cycling, was consistently reduced by both conventional and biodegradable MPs. The reductions were more pronounced after the second season and for the higher MP treatment. As the higher MP concentration (i.e., 0.05&nbsp;% w/w) is environmentally relevant in Europe, our findings emphasize the potential effects of environmentally relevant MP concentrations on soil health. Furthermore, the effects increased from north to south, probably modulated by varying pedoclimatic conditions, inducing reflection of a need for regionally tailored risk</div></div>

New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions

<h3>Charged for Action: The Hidden Secrets of AEX Oligonucleotide Analysis</h3>Oligonucleotides—short, well-defined fragments of DNA or RNA—have become indispensable tools in modern life sciences. They underpin cutting-edge applications in molecular diagnostics, gene therapy, and pharmaceutical development. Before oligonucleotides can be confidently used in research or clinical settings, however, their quality must be rigorously assessed. Purity, sequence integrity, length distribution, and chemical modifications all play a decisive role in their performance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg" alt="KNAUER: Oligos Made Easy - Part 2: AEX" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg 245w," sizes="100vw" width="1534" height="711">Among the analytical techniques available today, anion exchange chromatography (AEX) stands out as a robust and highly informative method for characterizing oligonucleotides. By exploiting their intrinsic negative charge, AEX provides detailed insight into product composition and impurity profiles that are difficult to obtain by other approaches.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6808">Part 1 of the Oligos series: A Practical Guide to Oligonucleotide Production – From Concept to Final Product</a></blockquote><h4>How Scientists Read Oligonucleotides Using Charge</h4>At the core of AEX lies a simple but powerful principle: oligonucleotides carry a negatively charged phosphate backbone. This charge increases in a predictable way with strand length and, to a lesser extent, sequence composition. Anion exchange chromatography uses this property to separate oligonucleotides based on differences in charge strength and interaction with a positively charged stationary phase.As a result, AEX has become one of the most widely used analytical tools for evaluating oligonucleotide quality. It allows scientists to distinguish full-length products from truncated species, degradation products, or closely related variants—often with single-nucleotide resolution.<h4>Why Ion Exchange Works: Binding, Retention, and Release</h4>Ion exchange chromatography (IEX) relies on electrostatic interactions between analytes and a charged stationary phase. In the case of oligonucleotides, anion exchange is used, where negatively charged molecules interact with positively charged functional groups on the resin—most commonly quaternary amines.The system consists of two main components:<ul><li>Stationary phase: A positively charged resin that binds anionic analytes.</li><li>Mobile phase: An aqueous buffer system, typically combined with a salt gradient, that controls both pH and elution strength.</li></ul>Retention in AEX is governed primarily by charge. Molecules with weaker overall charge interact less strongly with the stationary phase and elute earlier, while more highly charged oligonucleotides bind more tightly and require stronger elution conditions.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 1 IEX overview including elution order dependency on analyte charge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg 245w," sizes="100vw" width="1583" height="654"><h4>The Five-Step Workflow of Ion Exchange Chromatography</h4>AEX separations generally follow a well-established sequence of steps:<ol><li>Column equilibration The column is conditioned with the starting buffer until the baseline and pH are stable. This ensures that all charged sites on the resin are ready for interaction.</li><li>Sample loading Samples, prepared in the starting buffer, are introduced under conditions that promote binding of the target oligonucleotides while minimizing retention of unwanted impurities.</li><li>Washing The column is washed with the starting buffer to remove uncharged or weakly interacting components. The baseline stabilizes as these species are flushed away.</li><li>Elution Bound oligonucleotides are released using a salt or pH gradient. Increasing ionic strength introduces competing ions that displace the analytes from the resin. Weakly bound species elute first; strongly charged oligonucleotides elute later.</li><li>Regeneration and re-equilibration A high-salt buffer removes any remaining bound material. The column is then returned to starting conditions in preparation for the next analysis.</li></ol><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 2 Five steps of IEX procedure (in blue), outlined using an example chromatogram (in red)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg 245w," sizes="100vw" width="1583" height="674"><h4>Why AEX Is Especially Effective for Oligonucleotides</h4>The repeating phosphate backbone of oligonucleotides gives rise to a strong and uniform anionic character across a wide pH range (typically pH 7–9). This makes oligonucleotides exceptionally well suited for anion exchange separations.Key factors influencing AEX behavior include:<ul><li>Charge density: Longer oligonucleotides carry more negative charges and therefore exhibit stronger retention.</li><li>Resin chemistry: Strong and weak anion exchangers differ in functional groups and pH stability, influencing selectivity and robustness.</li><li>Buffer composition: The choice of buffering ions and salt gradients directly affects elution strength and resolution.</li></ul>Salt gradients—commonly based on chloride ions—compete with the oligonucleotide backbone for binding sites on the resin. By carefully tuning gradient slope and composition, analysts can achieve highly reproducible and finely resolved separations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 3 Ionic interactions and pH influence on Anion Exchange Chromatography (AEX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg 245w," sizes="100vw" width="1547" height="593"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 4 AEX buffer selection and gradient strategy (chromatogram with red buffer gradient curve)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg 245w," sizes="100vw" width="1600" height="327"><h4>AEX as the Gold Standard for Oligonucleotide Separation</h4>Anion exchange chromatography has become the method of choice for both analytical and preparative oligonucleotide workflows. Its advantages include:<ul><li>High resolving power: Closely related impurities, including n–1 or n–2 species, can often be separated and quantified.</li><li>Predictable retention behavior: In many cases, retention time correlates linearly with oligonucleotide length, simplifying identification.</li><li>Compatibility with modified oligonucleotides: Even chemically modified sequences retain their anionic nature, allowing AEX to resolve both products and related impurities.</li><li>Excellent control via gradient elution: Salt gradients provide precise tuning of selectivity and resolution.</li></ul>Typically, shorter or degraded oligonucleotides elute at lower ionic strength, while full-length products with higher charge density appear later in the chromatogram.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 5 AEX Advantages and Challenges." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg 245w," sizes="100vw" width="1535" height="707"><h4>Final Perspective: Mastering AEX with Confidence</h4>Anion exchange chromatography may appear complex at first, but with thoughtful optimization of pH, buffer composition, and gradient conditions, it becomes a highly precise and reliable tool for oligonucleotide analysis. When properly applied, AEX delivers sharp peaks, excellent resolution, and robust performance—even for challenging sequences and modifications.For laboratories developing or refining oligonucleotide workflows, AEX offers both analytical depth and operational confidence.<blockquote>If you would like to discuss AEX method development or optimization for oligonucleotides, feel free to contact us at sales@knauer.net. More insights into practical oligonucleotide analysis will follow in our “Oligos Made Easy” series.For technical questions or in-depth discussion, the author can be reached at kindler@knauer.net</blockquote>

Oligos Made Easy - Part 2: AEX

News from LabRulezLCMS Library - Week 07, 2026

Article

Application

Plastics

Environment

Science and research

Poster

RECETOX (Research Centre for Toxic Compounds in the Environment) is an independent department of the Faculty of Science of Masaryk University in Brno, which has been established in 1983. RECETOX is focused on the research and education in cross-cutting area of Environment and Health. It addresses interactions among chemicals, environment, and biological systems, including consequences at local, regional, and global levels.

RECETOX - Centrum pro výzkum toxických látek v prostředí

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Agilent Technologies

SelectScience

SCIEX

Waters Corporation

The hunt goes on, let's find the needle in the haystack:Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills. Learn how to select the appropriate statistical tools to make sense of your data and identify features of interest by visualizing trends and changes using various clustering and grouping approaches. We will also cover the construction of class prediction models to differentiate between sample cohorts effectively.Finally, gain a deeper understanding of your findings by mapping them onto relevant metabolomic pathways, providing essential context for your research.<blockquote>Presenter: Hannah Florance (Application Specialist LC/MS, Agilent Technologies)Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent. Presenter: Shaun Reeksting (Application Specialist LC/MS, Agilent Technologies)Shaun completed his PhD in Biochemistry, specializing in molecular parasitology a focus in metabolomics. Following his doctoral studies, he worked in accredited industry laboratories and academia core-facilities before joining Agilent Technologies as an LC/MS Application Engineer.In this role, Shaun focuses on environmental small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Agilent Technologies: MassHunter Masterclass Months

Finding the Needle in the Haystack Part II; All Things Chemometric

Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills.

All Things Chemometric

In our last session, we will tackle compliance as we will delve into the critical aspects of compliance and its significance for your laboratory.Discover what compliance entails and why it is essential for maintaining the integrity and reliability of your lab’s operations. We will explore the various configurations available to meet your specific regulatory requirements, ensuring you have the necessary tools and knowledge to stay compliant.Additionally, gain valuable insights into content management, audit trails, and applications that streamline your compliance processes, making your lab more efficient and secure.Don’t miss this opportunity to enhance your understanding of working in a regulated environment and ensure your lab’s success.<blockquote>Presenter: &nbsp;Christian Hegmanns (Application Specialist LC/MS, Agilent Technologies, Waldbronn, Germany.)Christian Hegmanns is a state-certified food chemist and works at Agilent as an LC/MS application specialist.With over 10 years of experience in the field of instrumental analysis, Christian develops customer-oriented solutions for a variety of applications with a focus on food analysis.</blockquote>

MassHunter Compliance – Working in a Regulated Environment

We will tackle compliance as we will delve into the critical aspects of compliance and its significance for your laboratory.

Therapeutic synthetic oligonucleotides face unique analytical challenges in late-stage development. Meeting stringent regulatory requirements demands highly specific and sensitive methods like LC-MS. However, typical QC analysts struggle with the complexity of purity, assay and impurity profiling due to limitations in current chromatography and mass spectrometry data systems.This webinar will explore a paradigm shift in software that streamlines the analytical workflow while maintaining data integrity and compliance. Our expert speakers will also discuss how to apply the Oligo Analysis Accelerator for OpenLabs CDS to your oligonucleotide therapeutic testing, helping you to optimize synthesis and purification.Attend this webinar to:<ul><li>Discover how fit-for-purpose software for LC-MS analysis in QC lot release can save time and enhance quality</li><li>Understand the fundamentals of ion-pair reversed phase LC-MS for oligonucleotides</li><li>Discover how to use single quadrupole detector for impurity profiling of anti-sense oligonucleotides</li></ul><blockquote>Presenter: Charlotte Lekieffre, PhD (Biopharma Application Specialist, Agilent Technologies)Charlotte holds a PhD from the Ecole Polytechnique Fédérale de Lausanne and has 10 years' experience in developing analytical workflows for mass spectrometry. She now brings her expertise to Agilent's customers as an LCMS Application Specialist in the BioPharma sector.Presenter: Kevin Koelliker (Lab Informatics Application Engineer at Agilent Technologies)Kevin is a Lab Informatics Application Engineer for Agilent Technologies. He studied Chemistry and Business informatics, and he worked as a Lab Technician, and as a Field Service Engineer before joining Agilent. Combined he has more than 15 Years of Experience in the analytical laboratory and therefore met already multiple different workflows. He works together with the Lab Informatics Product Specialists to demonstrate the Power of OpenLab, and to customize it to meet the needs of our Customers.</blockquote>

Technology Networks: Mastering QC Oligonucleotide LC-MS in GMP Labs

Mastering QC Oligonucleotide LC-MS in GMP Labs

This webinar will explore a paradigm shift in software that streamlines the analytical workflow while maintaining data integrity and compliance.

In this webinar, Novartis will show how they are digitalizing and fully automating systems across large molecule R&amp;D. By integrating liquid handling systems, mass spectrometers, and the Genedata Biopharma platform, Novartis has implemented a ‘full-circle’ mass spectrometry (MS) workflow automation for standardized analyses. Their automated MS workflow includes analytics requests by laboratory scientists, barcoding, sample preparation, mass spectrometry, data analysis, and reporting. Automating repetitive tasks increases efficiency and allows scientists to focus on more complex projects and advanced sample analytics.Join Felix Stemmer, Senior Scientist II, and Martin Jockel, Senior Expert in Data Science, from Novartis as they illustrate how they are streamlining processes and accelerating operations.Key learning objectives<ul><li>Discover how Novartis is automating complex MS-based workflows in biopharma R&amp;D</li><li>Learn how Novartis has implemented a ‘full-circle’ MS analytics platform, integrating high quality MS data into an enterprise-level biotherapeutics discovery platform</li><li>Hear how Novartis scientists significantly increased research efficiency by using MS analytics workflows</li></ul>Who should attend?<ul><li>Biopharmaceutical analytical scientists, laboratory leaders, and directors who are looking to develop and automate MS-based analytics in biotherapeutic R&amp;D.</li><li>IT professionals, automation architects, and engineers looking to support organizational-level data platforms for digitalization of complex, multidimensional data streams in biologics discovery workflows.</li></ul>Certificate of attendanceAll webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.<blockquote>Presenter: Martin Jockel (Senior Expert I Data Science, Novartis)Martin Jockel, a bioinformatics graduate from the Technical University of Applied Sciences in Bingen, has worked for Novartis for the past 12 years. His proficiency in crafting custom software solutions has enhanced laboratories’ capabilities in data storage and visualization, leading to optimized workflows and increased efficiency.In recent years, Jockel has further broadened his scope to include lab automation, ensuring these processes are integrated into Novartis’ technical ecosystem. For the past three years, he has been contributing to the Genedata project at Novartis as a developer and as the Scrum Master for the Technical Team.Presenter: Felix Stemmer (Senior Scientist II, Novartis)Felix Stemmer has a background in bioengineering from the Karlsruhe Institute of Technology where his passion for lab automation began. Now working at Novartis, Stemmer is currently working on a collaborative project with Genedata, integrating liquid handling systems and analytical instruments into Genedata’s respective software.Before joining Novartis, Stemmer worked on a series of automation projects including miniaturizing downstream processing and CHO and HEK upstream processing, highlighting his extensive experience in automation.</blockquote>

SelectScience: Full-Circle MS Workflow Automation at Novartis

Full-Circle MS Workflow Automation at Novartis

Novartis will show how they are digitalizing and fully automating systems across large molecule R&D.

Innovating for the future with cutting-edge solutionsGiven the speed and scale of progress with Artificial Intelligence (AI) in today’s world, researchers and professionals across various scientific fields from the Danaher group of companies have stepped up in the game of AI and advanced technology to seek breakthrough solutions to age-old problems.<h3>Agenda</h3><h5>Introduction to Danaher</h5><h5>3D biology and the paradigm shift in next generation drug discovery</h5><ul><li>Presented by Molecular Device</li></ul><h5>AIVIA - introduction to AI based image analysis</h5><ul><li>Presented by Leica Microsystems</li></ul><h5>Analytical advances in the characterization of mRNA</h5><ul><li>Presented by Phenomenex</li></ul><h5>Unlocking the power of data with IDBS</h5><ul><li>Presented by IDBS</li></ul><h5>The power of AI: from planning and the lab to success in life sciences</h5><ul><li>Presented by Abcam</li></ul><h5>Practical approaches to EV characterization and purification: leveraging nano Flow Cytometry and ultracentrifugation for clinical and commercial success</h5><ul><li>Presented by Beckman Coulter Life Sciences</li></ul><h5>AI-MS/MS-AI mass spectrometry application with AI</h5><ul><li>Presented by SCIEX</li></ul><h5>Work smarter, not harder: emerging lessons on data in biopharma R&amp;D</h5><ul><li>Presented by Genedata</li></ul><h5>In silico process development with mechanistic chromatography modelling</h5><ul><li>Presented by Cytiva</li></ul><h5>CRISPR meets NGS: the powerful duo for drug discovery</h5><ul><li>Presented by IDT</li></ul><h3>Presenter:</h3><ul><li>Gokhale, Aarti Arun, Ph.D (Sr Manager, Gene Reading, APAC, IDT)</li><li>Teo Chong Kok Ph.D (Scientific Account Manager, Genedata)</li><li>Edward Lim (General Manager, SEA, Beckman Coulter Life Sciences)</li><li>Taryn Guinan, Ph.D (Sr Applications Specialist, ANZ, Leica Microsystem)</li><li>Edward Wong, Ph.D (Sr Manager, Gene Writing &amp; Editing, APAC, IDT)</li><li>Stephan Waldert, Ph.D (Director, Data Science &amp; AI, Abcam)</li><li>Manish Manakchand (Commercial Director, Asia, IDBS)</li><li>Namrata Saxena (Technical Manager, Phenomenex)</li><li>Hans Lin (Field Application &amp; Market Development Specialist, SCIEX)</li><li>Mok Wei Chuan (Go Silico Sales Specialist, APAC, Cytiva)</li><li>Minho Tak, Ph.D (Sr Application Scientist, JAPAC, Molecular Device)</li></ul>

SCIEX: AI and technology advancements from Danaher

AI and technology advancements from Danaher

In this live webinar, let’s explore how Danaher group of companies leverage AI and technologies in providing advanced solutions.

<div>Join us for the first-ever Semicon e-Symposium, a one-day virtual event featuring expert discussions on crucial topics in the semiconductor industry, including yield improvement, sustainability, PFAS analysis, and advanced analytical techniques.Here’s why you don’t want to miss this:<ul><li>Discover how leading-edge analytical solutions are driving innovation, featuring a plenary talk by Dr. Stefanie Fingerhut from Merck KGaA on transforming semiconductor materials for mobile technology.</li><li>Explore key advancements in vacuum technology and regulatory updates.</li><li>Gain actionable insights from experts in GC-ICP-MS, UV-Vis spectroscopy, and a special talk by Inès Tendero from Technic France on the analysis of silicon in high-purity matrices.</li></ul>This is a must-attend event for anyone looking to stay informed on key trends and cutting-edge advancements in semiconductor manufacturing. Don’t miss out—register today!<h4>Agenda</h4>8:30 a.m. How Analytical Techniques Contribute to Yield Improvement and Environmental Sustainability in the Semiconductor Industry<ul><li>Gernot Hudin, Agilent Technologies</li></ul>9:00 a.m. Plenary Talk: The Hidden Connection: Merck's Advanced Analytical Techniques Transforming Semiconductor Materials for Mobile Technology<ul><li>Dr. Stefanie Fingerhut, Merck KGaA</li></ul>9:45 a.m. Agilent ICP-MS Supplies Selection Tips for the Semiconductor Industry&nbsp;<ul><li>Alain Desprez, Agilent Technologies</li></ul>10:00 a.m. PFAS 'Forever Chemicals'—Forever a Problem?<ul><li>Shifen Xu, Agilent Technologies</li></ul>10:30 a.m. Quantitative Workflow for the Analysis of PFAS in Semiconductor Lubricant with LC-MS (Q-TOF)<ul><li>Peter Kornas, Agilent Technologies</li></ul>11:00 a.m. Agilent Vacuum in Semiconductor Market<ul><li>Fabio Ardissone, Agilent Technologies</li></ul>11:30 a.m. GC, GC/MS, and GC-ICP-MS in Semiconductor: What, Why, and How?<ul><li>Stephane Decouflet, Agilent Technologies</li></ul>12:00 p.m. Lunch break1:00 p.m. Semiconductor Application of Single Particle ICP-MS<ul><li>Yoshinori Shimamura, Agilent Technologies</li></ul>1:30 p.m. Is It Possible to Identify Organic Solvents by ICP-MS?<ul><li>Katsuo Mizobuchi, Agilent Technologies</li></ul>2:00 p.m. Special talk: Analysis of Si in High-Purity Matrix for Semiconductor Application&nbsp;<ul><li>Inès Tendero, Technic France</li></ul>2:30 p.m. Measuring the Band Gap Energy Using UV-Vis Spectroscopy<ul><li>Marcus Schulz, Agilent Technologies</li></ul>2:45 p.m. Recap—closing session<ul><li>Gernot Hudin, Agilent Technologies</li></ul></div>

Semicon e-Symposium 2024

Expert discussions on crucial topics in the semiconductor industry.

Join Dr. Katie Horton, medical science liaison specialist – EXENT and Dr. Mark Perkins, senior manager, portfolio lifecycle – EXENT, The Binding Site, as they discuss the development and performance of the EXENT® System, a clinical mass spectrometry solution for monoclonal gammopathy assessment.The EXENT System is an automated solution that enables M-protein identification and measurement in serum with enhanced sensitivity beyond conventional methods.The system combines&nbsp;the EXENT&nbsp;Analyzer&nbsp;with the EXENT GAM Assay to&nbsp;provide a fully automated solution&nbsp;to isotype, quantify and track monoclonal&nbsp;proteins throughout the patient journey.​Key learning objectives<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Understand the role of mass spectrometry (MS) in monoclonal protein testing</li><li style="tab-stops:list 36.0pt;">Explore the analytical performance of the EXENT System using MALDI-ToF MS technology</li><li style="tab-stops:list 36.0pt;">Understand the potential clinical impact of mass spectrometry for patients with monoclonal gammopathies</li></ul>Who should attend?Laboratory professionals, hematologists, and primary care professionals who would like to learn more about the latest innovation for monoclonal gammopathy assessment.Certificate of attendance All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes. The EXENT Analyser and Immunoglobulin Isotypes (GAM) for EXENT Analyser are only commercially available in Australia, New Zealand, United Kingdom, Switzerland and the EEA. The products are not commercially available in the USA or China, future commercial availability cannot be guaranteed.Product availability is subject to country specific regulatory requirements. Contact your local representative for availability in your country.<blockquote>Presenter: Dr. Mark Perkins (Senior Manager, Portfolio Lifecycle - EXENT, The Binding Site, part of Thermo Fisher Scientific)Dr. Mark Perkins has over 20 years of experience in the life science and diagnostic industry. He led the team responsible for the design and development of the EXENT solution and currently manages the team responsible for clinical and education evidence generation for the EXENT System.Presenter: Dr Katie Horton (Medical Science Liaison - EXENT, The Binding Site, part of Thermo Fisher Scientific)Dr. Katie Horton has over five years’ experience working in a UK National Health Service (NHS) diagnostic clinic. She now works as a medical science liaison specialist using her mass spectrometry and clinical diagnostics expertise to help drive forward the clinical evidence generation and educational initiatives for the EXENT System.</blockquote>

SelectScience: Transforming M-protein diagnostics with mass spectrometry using the EXENT® System

Transforming M-protein diagnostics with mass spectrometry using the EXENT® System

Join us as we discuss the development and performance of the EXENT® System, a clinical mass spectrometry solution for monoclonal gammopathy assessment.

M-protein diagnostics with MS using the EXENT®

Session 1:The fundamental unit of a living organism is the single cell. What are the benefits and issues with pushing towards single cell measurements? The overarching goal is to provide an understanding of why discovery based single cell analysis is important and achievable. Several example applications highlight single cell metabolites including amino acids, small bio-active neuropeptides and neurotransmitters. Metabolites in individual cells were characterized using capillary electrophoresis (CE) with MRM MS with the QqQ-MS. The sample preparation steps were performed in vial inserts in the CE system to reduce the solution requirements of the autosampler to ~2 µL. Other changes to the system include a nanointerface and a mechanically tapered capillary tip for optimized detectability. The CE-nanoESI-QqQ MS system demonstrated detection limits at the single attomole level for a range of amino acids and transmitters. We characterize a range of cells including Aplysia californica neurons, rodent neurons, transplant-quality islets, and individual endocrine cells. The combination of nanovial CE-nanoESI-QqQ MS, interface, auto sampler, and fast MRM measurements enables high-throughput, high-sensitivity, and robust metabolite analysis of single cells.Key learning objectives<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Why single cell assays provide key details</li><li style="tab-stops:list 36.0pt;">How to prepare single cells for measurements</li><li style="tab-stops:list 36.0pt;">Why CE/MS works well for single cell metabolomics</li><li style="tab-stops:list 36.0pt;">Benefits of a targeted QQQ approach</li><li style="tab-stops:list 36.0pt;">How to reduce sample volumes</li><li style="tab-stops:list 36.0pt;">On going optimization of CEMS interface</li><li style="tab-stops:list 36.0pt;">Quantify differences in metabolic levels between cells</li><li style="tab-stops:list 36.0pt;">Scientists in the life sciences, with a focus on discovery, or a need for large-scale analyses</li></ul>Who should attend?<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Discovery groups involved with identifying and quantifying biomarkers. Researchers who are sample limited.</li></ul>Session 2:Untargeted metabolomics and lipidomics have traditionally been seen as primarily academic pursuits, often dismissed in clinical research due to perceived challenges in scalability and reproducibility. However, the emergence of precision health, which relies on the concept of digital twins—comprehensive digital representations of the complete molecular content of biological specimens—necessitates the use of untargeted approaches. These methods, in theory, offer the potential to explore an extensive chemical space. But what does it take to implement such analyses on a large scale, aiming both for accuracy in quantification and extensive identification? This presentation will highlight the key lessons learned from the Swiss Personalized Health Initiative.Key learning objectives<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Why is QTOF technology ideally suited for untargeted analyses, both for metabolites and lipidomics</li><li style="tab-stops:list 36.0pt;">What are the critical factors to perform large scale LC-MS (LC, MS, DDA)</li><li style="tab-stops:list 36.0pt;">Harmonization of large-scale data</li></ul>Who should attend?<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Scientists in the life sciences, with a focus on discovery, or a need for large-scale analyses</li></ul>Certificate of attendance All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.<blockquote>Presenter: Dr. Jonathan V. SweedlerJames R. Eiszner Family Endowed Professor of Chemistry and is affiliated with the Institute of Genomic Biology and the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign, University of Illinois Urbana-ChampaignDr. Sweedler’s research interests focus on developing new lipidomics, metabolomics and peptidomics approaches for assaying small volume samples including new sampling approaches, miniaturized separations, and mass spectrometry. He has used these tools to characterize small molecules and peptides in a range of animal models across metazoan life and in samples as small as individual cells and cellular domains. Sweedler has published more than 500 manuscripts and presented more than 600 invited lectures. &nbsp;He has received numerous awards including the Instrumentation Award from the Analytical Division of the ACS, the Pittsburgh Analytical Chemistry Award, and the ACS Award in Analytical Chemistry. He is a fellow of both the American Association for the Advancement of Science and the American Chemical Society. He is currently the Editor-in-Chief for Analytical Chemistry.Presenter: Prof. Dr. Nicola ZamboniProfessor at the Institute of Molecular Systems Biology of ETH Zurich, and head of the PHRT Clinical Metabolomics Analysis Center., ETH ZurichNicola Zamboni’s research pivots on investigating metabolism and its regulation, from cells to humans. The lab relies heavily on mass spectrometry to quantify levels and rates of conversion of metabolites. In parallel, it develops computational approaches to enable large-scale data acquisition and integration. The lab is embedded in the Swiss personalized health initiatives as main provider of metabolomics and lipidomics for clinical research.Moderator: Matilde Marques (Life Sciences Assistant Editor, SelectScience)</blockquote>

SelectScience: Metabolomics Masterclass: Cutting-Edge Techniques for Single Cell Analysis and Precision Health at Scale

Metabolomics Masterclass: Cutting-Edge Techniques for Single Cell Analysis and Precision Health at Scale

In two sessions, single-cell metabolomics and untargeted metabolomics, and lipidomics will be discussed.

Metabolomics Masterclass: Single Cell Analysis

The analysis of biomolecules, with the development of increasingly complex products and the rise in regulatory requirements, is challenging.Our expertise in chromatography, mass spectrometry, and data analysis allows us to combine the most advanced technologies to offer solutions that meet your needs regarding:<ul style="list-style-type:disc;margin-top:0in;" type="disc"><li style="color:rgb(0, 0, 0);">Quality and reliability of your results</li><li style="color:rgb(0, 0, 0);">Productivity</li><li style="color:rgb(0, 0, 0);">Ease of use</li><li style="color:rgb(0, 0, 0);">Compliance with regulatory agency standards</li></ul>In this seminar, we will present some of the&nbsp;most recent and relevant applications in the analysis, quantification, and characterization of biomolecules&nbsp;such as proteins, RNA, peptides, oligonucleotides, nucleic acids, viral vectors, lipid nanoparticles, glycans, or amino acids.Join us to discover how our analytical solutions can help you overcome current and future challenges in the field of biomolecule analysis.<div><div><div dir=""><div><blockquote><div>Presenter: Ben Wilkes (Principal Biologics Market Development Manager, Waters)</div></blockquote></div></div></div><div><blockquote>Since 2022, Ben Wilkes is a Principal Biologics Market Development Manager at Waters where he connects biotech companies with enabling analytical technologies, focusing on liquid chromatography and mass spectrometry. Prior to Waters, Ben worked at Lonza Biologics from 2015 to 2022 as an analytical R&amp;D scientist, supporting all aspects of a products lifecycle with novel analytical methods. He also previously worked at Abzena and Sanofi-Genzyme after graduating from the University of Manchester in 2012Presenter: Alberto Méndez (Chat) (MS Specialist, Spain and Portugal, Waters)Presenter: Pablo de la Iglesia (Chat) (MS Specialist, Spain, Waters)</blockquote></div></div>

Waters Corporation: Advanced Analytical Solutions for Biomolecule Analysis

Advanced Analytical Solutions for Biomolecule Analysis

We will present some of the most recent and relevant applications in the analysis, quantification, and characterization of biomolecules.

Get the most out your LC-MS/MS and how to achieve optimal assay parameters by exploring dwell time functionality its impact on the quality of your results.&nbsp;This webinar is dedicated to new and experienced LC-MS/MS users looking to build on their expertise and increase their mass spectrometry knowledge.&nbsp;Our presenter, Brad Patterson, PhD, will take you through dwell time considerations and explain with examples:<ul><li>The relationship between dwell time and sensitivity</li><li>Which dwell time to choose for your assay</li><li>How to calculate the best cycle time for your assay</li></ul>We do hope can join us. Regsiter now<blockquote>Presenter:&nbsp; Brad Patterson, PhD (ANZ Field Applications Manager, SCIEX)Brad obtained his PhD in Chemistry at James Cook University in 2001 and has been involved with mass spectrometry ever since. Brad is based in Melbourne, Victoria and has worked for SCIEX for 18 years. He has been training people on and performing LC-MS/MS development for more than 20 years and in this time has supported many applications in many industries throughout the world, primarily in Australia and New Zealand</blockquote>

SCIEX: Exploration of mass spectrometry dwell time webinar

Exploration of mass spectrometry dwell time webinar

Get the most out your LC-MS/MS and how to achieve optimal assay parameters by exploring dwell time functionality its impact on the quality of your results.

LCMS webinars focusing on LC/MS - page 36