Tasty beer starts with knowing what’s in your hops. Explore how online SPE makes bitter acid analysis in hops faster and more reliable.<h4>How can you detect bitter acid profiles quickly, reliably, and more sustainably?</h4>For craft brewers and beer lovers alike, a refreshing experience is all about flavor.So how can you achieve the desired bitterness in your beer? The answer is not just about the recipe. Finding the right flavor profile starts with the bitter acids present in the starting hops material.<div><div>Hops (the heart of your favorite beer) are the source of the brew’s distinctive flavor tied to bitterness and aroma.At the molecular level, bitterness is driven by <a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0308814622016338">α- and β-bitter acids</a>, like humulones and lupulones, whose concentrations determine the final sensory profile of the beer (Figure 1).Accurately characterizing these compounds in each batch allows brewers to unlock the full potential of every variety of hops.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 1. General chemical structure of hop bitter acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg 222w," sizes="100vw" width="700" height="493">While conventional analytical methods rely on long, manual sample preparation steps and hazardous solvents, laboratories now strive for greener and more efficient workflows.And moving from manual to online sample preparation is one of the easiest ways your lab can reduce waste and — most importantly — improve reliability with automation.<h4>Key takeaways</h4><ul><li>Online SPE reduces hands-on work, shortens turnaround time, and supports more sustainable methods by cutting solvent use and eliminating single-use cartridges.</li><li>Automated UHPLC workflows are easier for new users to execute, offering more reproducible quantifications of α- and β-bitter acids in hops.</li><li>Accurate bitter acid profiles help brewers distinguish hop varieties and control flavor with confidence.</li></ul><h4>Comparing offline vs. online solid phase extraction for bitter acid HPLC analysis</h4>If you’ve spent long hours in the lab preparing samples for hops analysis, you’re not alone.Manual sample preparation often takes the most time in hops analysis, an area where online <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/chromatography-learning-center/chromatography-consumables/sample-prep.html">solid phase extraction</a> (SPE) can make a real difference. Here’s why.Manual SPE has a lot of manual steps. Extraction. Cartridge loading. Washing. Elution. And sometimes solvent exchange or reduction. All before your actual analysis begins. This labor-intensive workflow can take up to an hour and depends strongly on operator skillsets, making reproducibility a challenge for new hires.<h4>Online SPE analysis provides key benefits like:</h4><ul><li>Hands-off workflow free of cartridges, manifolds, or vacuum steps.</li><li>Column washing and re-equilibration occur in parallel with separation.</li><li>SPE step is complete in just two minutes.</li><li>Minimizes operator-dependent variability.</li><li>Uses less than 8 mL of solvent.</li></ul>Let’s explore what this technique looks like in practice.<h4>Online SPE for analyzing α- and β-bitter acids in hops standard solutions.</h4>Changing your sample preparation from manual to automated isn’t complicated. With the right tools you can fully integrate online SPE with your UHPLC system (Figure 2).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 2. Schematic workflow for the determination of bitter acids in hops. The process involves clean up and instrumental analysis using the Thermo Scientific Vanquish Online SPE UHPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg 245w," sizes="100vw" width="700" height="323"><h4>The process for analyzing a hops standard solution is straightforward:</h4><ol><li>First, extract hop samples with ethanol (a greener alternative to toluene or diethyl ether in conventional methods).</li><li>Inject the extract directly into your instrument for analysis. Bitter acids retain<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1970"> on the SPE column</a> while matrix interferences that can comprise quantitation are removed.</li><li>Next, backflush the SPE column to transfer the analytes to the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/423"> analytical column </a>for separation. While this separation is taking place, the SPE column is washed and re-equilibrated in parallel, keeping the total run time to 15 minutes, with the separation of all six major bitter acids in a single analysis (Figure 3).</li></ol><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 3. UV chromatogram of hop bitter acids in standard solution (1-cohumulone, 2-humulone, 3-adhumulone, 4-colupulone, 5-lupulone, 6-adlupulone)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg 245w," sizes="100vw" width="700" height="347"><h4>Online SPE for analyzing α- and β-bitter acids in real hops samples</h4>Analytical labs need methods that are accurate and reliable for brewers to develop distinct and reproducible flavor profiles across batches.To assess the applicability of online SPE UHPLC methods for hops analysis, we analyzed bitter acid profiles from four species — Sultana, Barbe Rouge, Azacca, and Sabro.The concentration of α-acids dominated all samples, while each hops species exhibited distinct profiles in terms of α-acid and β-acid content, making them suitable for different brewing strategies (Figure 4).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 4. Bitter acid profiles in four different hop species, error bars display SD (n=6). To check method consistency, we measured each hops extract six times. Variation between measurements was low, with relative standard deviation below 3.5 % across all hops species." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg 245w," sizes="100vw" width="700" height="410"><ul><li>For testing labs, this process translates into a workflow that is easy to run, fast, and delivers reliable results without added complexity.</li><li>For craft brewers, reliability means clear, trustworthy insights into hops bitter acid profiles, for better hop selection and more precise control of bitterness and flavor in your beer.</li></ul><h4>From carefully procured samples to tasty sips</h4>Efficient UHPLC workflows support faster results, less solvent use, and reliable bitterness data for brewers. And online SPE turns those advantages into practical, day-to-day benefits for brewers and labs alike.<ul><li>Less hands-on skills required for lab analysts</li><li>Faster results from labs to brewers</li><li>A more sustainable way to work</li><li>Clear insights into hops flavor</li></ul>To learn more about the method and see the full application data, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cn_004238_hplc_vanquish_online_spe_bitter_acids_hops_cn004238_na_en_587a5d300b.pdf">check out our application note today</a>.<h4>FAQs</h4><div><div><h5>What are the key compounds in hops analyzed by HPLC?</h5>Bitter acids, namely α-acids and β-acids, especially the six major bitter acids (humulones and lupulones) that define hop bitterness and are required for quality control and brewing decisions.</div><div><h5>What column types are recommended for hop acid separations?</h5>Classical C18 Silica columns are ideal for bitter acids separation. UHPLC compatible columns with particle size ≤ 2 µm boost analysis with higher flow rate, thus shorter analysis time and solvent consumption.</div><div><h5>What’s the best workflow for hops analysis?</h5>A typical workflow for hop analysis consists of three main steps: extraction of the target compounds, clean-up of co-extracted matrix components, and instrumental analysis by HPLC or UHPLC. To keep this workflow efficient and reproducible, you should minimize manual handling and add in automation when possible. Integrating online SPE into your LC instrument allows sample clean-up to run automatically, reducing hands-on time, solvent use, and variability while delivering faster, more reliable results.</div></div><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#UHPLC #Automation</blockquote></div></div>

How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors

In the week of June 29, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Insights from an IC specialist: To be suppressed or not suppressed?</h5><ul><li>Tu, 30.6.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6310">Registration</a></li></ul>Join Thermo Fisher’s Ask the Experts session to learn how suppressor technology impacts ion chromatography performance, sensitivity, reliability, maintenance, and troubleshooting.<h5>2. SCIEX: Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery</h5><ul><li>Tu, 30.6.2026 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6311">Registration</a></li></ul>Discover how ZenoTOF high-resolution mass spectrometry is accelerating single-cell proteomics and plasma biomarker discovery through enhanced sensitivity, throughput, and automation.<h5>3. Agilent Technologies: Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres</h5><ul><li>Tu, 30.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6052">Registration</a></li></ul>This webinar will discuss diffuse transmission and reflection UV/VIS measurements, including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer.<h5>4. Waters Corporation: Informatics series #33 Tips, Tricks and Best Practices</h5><ul><li>Th, 2.7.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6315">Registration</a></li></ul>This interactive session revisits essential features, shortcuts, and practical techniques in Empower software that can streamline everyday laboratory work and reduce unnecessary effort.<h5>5. Waters Corporation: Unlocking Therapeutic Peptide Characterisation (GLP-1RAs) with Cyclic IMS</h5><ul><li>Th, 2.7.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6313">Registration</a></li></ul>Discover how cyclic ion mobility spectrometry (cyclic IMS) improves characterization of GLP-1 analogues and therapeutic peptides, supporting development, quality control, and regulatory submissions.<h5>6. Agilent Technologies: Spectral Flow Cytometry Masterclass - Session 1</h5><ul><li>Fr, 3.7.2026 07:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6316">Registration</a></li></ul>Learn how full-spectrum flow cytometry enables high-dimensional cell analysis. Explore spectral flow technology, experimental design, and applications in immunology, oncology, and vaccine research.

Webinars LabRulezLCMS Week 27/2026

The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607">A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;<h4>Evaluation of measurement procedure performance&nbsp;</h4>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;<ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"><h4>Characterisation of candidate reference materials&nbsp;</h4>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;<ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4>Other ILCs&nbsp;</h4>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).

Interlaboratory comparisons other than proficiency testing

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SCIEX

<h4>LC-MS/MS fundamentals webinar series 2.0</h4>
Advanced techniques for data acquisition and processing
Elevate your analytical expertise with advanced techniques and workflows
Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series. Based on our LC-MS/MS 1.0 webinar series, these sessions will go beyond the fundamentals of LC-MS/MS and introduce ways to advance your analytical methods and data processing workflows.
Every other week, we will explore how to optimize SCIEX OS software with short, 30-minute expert-led presentations.
<h4>This webinar:</h4>
June 18, 2024 11:00 a.m. - 11:30 a.m. CET - It&#39;s a TRAP! Getting the most out of your QTRAP system
Learn when to utilize QTRAP functionality to create more selective and sensitive methods.
<h4>Other webinars from the series:</h4>
May 7, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.cz/webinar/3820">Beyond the fundamentals</a>
May 21, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3852">Advanced MS/MS method building</a>
Gain insight into advanced features for maximizing sensitivity in your mass spectrometry analyses.
June 4, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3853">Mastering chromatography</a>
Discover how to optimize your chromatography for even the most challenging compounds while creating and building LC methods.
July 2, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3855">Troubleshooting at the source</a>
Acquire the knowledge needed to optimize source parameters and identify and resolve ionization-related problems.
July 16, 2024 11:00 a.m. - 11:30 a.m. CET <a href="https://lcms.labrulez.com/webinar/3856">Automating data processing</a>
Learn how to automate your data processing with custom flagging and rules for efficient data review in SCIEX OS software.
July 30, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3857">Excel strategies for mass spectrometry data analysis</a>
Take an in-depth look at when and how to use Excel to increase your productivity.

SCIEX: LC-MS/MS fundamentals webinar series 2.0

It's a TRAP! Getting the most out of your QTRAP system

Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series.

<h4>LC-MS/MS fundamentals webinar series 2.0</h4>
Advanced techniques for data acquisition and processing
Elevate your analytical expertise with advanced techniques and workflows
Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series. Based on our LC-MS/MS 1.0 webinar series, these sessions will go beyond the fundamentals of LC-MS/MS and introduce ways to advance your analytical methods and data processing workflows.
Every other week, we will explore how to optimize SCIEX OS software with short, 30-minute expert-led presentations.
<h4>This webinar:</h4>
July 2, 2024 11:00 a.m. - 11:30 a.m. CET - Troubleshooting at the source
Acquire the knowledge needed to optimize source parameters and identify and resolve ionization-related problems.
<h4>Other webinars from the series:</h4>
May 7, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.cz/webinar/3820">Beyond the fundamentals</a>
May 21, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3852">Advanced MS/MS method building</a>
Gain insight into advanced features for maximizing sensitivity in your mass spectrometry analyses.
June 4, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3853">Mastering chromatography</a>
Discover how to optimize your chromatography for even the most challenging compounds while creating and building LC methods.
June 18, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3854">It&#39;s a TRAP! Getting the most out of your QTRAP system</a>
Learn when to utilize QTRAP functionality to create more selective and sensitive methods.
July 16, 2024 11:00 a.m. - 11:30 a.m. CET <a href="https://lcms.labrulez.com/webinar/3856">Automating data processing</a>
Learn how to automate your data processing with custom flagging and rules for efficient data review in SCIEX OS software.
July 30, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3857">Excel strategies for mass spectrometry data analysis</a>
Take an in-depth look at when and how to use Excel to increase your productivity.

Troubleshooting at the source

Elevate your analytical expertise with advanced techniques and workflows.

Troubleshooting at the source in LC-MS/MS

<h4>LC-MS/MS fundamentals webinar series 2.0</h4>
Advanced techniques for data acquisition and processing
Elevate your analytical expertise with advanced techniques and workflows
Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series. Based on our LC-MS/MS 1.0 webinar series, these sessions will go beyond the fundamentals of LC-MS/MS and introduce ways to advance your analytical methods and data processing workflows.
Every other week, we will explore how to optimize SCIEX OS software with short, 30-minute expert-led presentations.
<h4>This webinar:</h4>
July 16, 2024 11:00 a.m. - 11:30 a.m. CET Automating data processing
Learn how to automate your data processing with custom flagging and rules for efficient data review in SCIEX OS software.
<h4>Other webinars from the series:</h4>
May 7, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.cz/webinar/3820">Beyond the fundamentals</a>
May 21, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3852">Advanced MS/MS method building</a>
Gain insight into advanced features for maximizing sensitivity in your mass spectrometry analyses.
June 4, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3853">Mastering chromatography</a>
Discover how to optimize your chromatography for even the most challenging compounds while creating and building LC methods.
June 18, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3854">It&#39;s a TRAP! Getting the most out of your QTRAP system</a>
Learn when to utilize QTRAP functionality to create more selective and sensitive methods.
July 2, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3855">Troubleshooting at the source</a>
Acquire the knowledge needed to optimize source parameters and identify and resolve ionization-related problems.
July 30, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3857">Excel strategies for mass spectrometry data analysis</a>
Take an in-depth look at when and how to use Excel to increase your productivity.

Automating data processing

Automating data processing in LC-MS/MS

Join us for a glimpse into the groundbreaking world of tomorrow’s research labs.
This immersive webinar offers an exclusive glimpse into the groundbreaking technologies shaping the laboratories of tomorrow. Delve into the dynamic fusion of cutting-edge technology and scientific exploration as our visionary experts unveil revolutionary laboratory setups.
Attend this webinar to:
<ul>
<li>Uncover strategies for enhancing the predictability and efficacy of synthetic biology</li>
<li>Navigate the transformative landscape of machine learning and automation in scientific research</li>
<li>Recognize the latest trends and updates in regulatory guidance documents related to data integrity </li>
<li>Attain more comprehensive results with new cutting-edge workflows for peptide and protein characterization</li>
</ul>
<blockquote>
Presenter: Joseph Meeuwsen, PhD (Product Manager ExD, Agilent Technologies)
</blockquote>
<blockquote>
**Presenter:**Sandra Soderholm, PhD (Application Development Scientist, Lab Essentials, Sartorius)
</blockquote>
<blockquote>
**Presenter:**Héctor García Martín, PhD (Staff Scientist, Lawrence Berkley National Lab)
</blockquote>
<blockquote>
**Presenter:**Viktor Kravchuk (Application Specialist Lab Weighing and Digital Solutions, Sartorius)
</blockquote>
<blockquote>
**Presenter:**Christian Klein, PhD (Product Manager LC/Q-TOF, Agilent Technologies)
</blockquote>

Technology Networks: Laboratory of the Future: A Tech Spotlight on the Future of Research

Laboratory of the Future: A Tech Spotlight on the Future of Research

An exclusive glimpse into the groundbreaking technologies shaping the laboratories of tomorrow.

A Tech Spotlight on the Future of Research

Analyzing low-level analytes in complex biological matrices while maintaining superior sensitivity over the length of the study is a challenge for many researchers. Thus, triple quadrupole mass spectrometers are widely used in quantitative bioanalysis for their accuracy and precise measurement of pharmaceutical drugs in these complex matrices.
In this presentation, our speaker will introduce technology advancements that help ensure the highest levels of performance are maintained. He will share data that demonstrates how triple quadrupole mass spectrometers provide not only exceptional sensitivity but additional stability to support challenging bioanalytical workflows.
Attend this webinar to discover:
<ul>
<li>Technology innovations to support robust long-term bioanalysis</li>
<li>Best practices to achieve accurate and precise measurements by LC-MS in bioanalysis</li>
<li>How to preserve long-term method sensitivity in complex matrices</li>
</ul>
<blockquote>
Presenter: Rahul Baghla (Manager, Global Scientific Marketing, SCIEX)
</blockquote>

Technology Networks: Ensure Accuracy and Precision in Pharmaceutical Bioanalysis

Ensure Accuracy and Precision in Pharmaceutical Bioanalysis

Triple quadrupole mass spectrometers provide exceptional sensitivity and additional stability to support challenging bioanalytical workflows.

Accuracy and Precision in Pharmaceutical Bioanalysis

The PFAS global research and testing community are now being asked to fully characterize PFAS in samples. Targeted analysis relies on a limited number of available reference standards, however it is well known that thousands of PFAS compounds and transformation products exist in the environment. To support laboratories, Thermo Fisher Scientific has worked with collaborators to develop a novel workflow to provide a better understanding of the diversity of PFAS contamination in samples, and at the same time provide meaningful targeted quantitative results in a variety of matrices.
In this webinar, our experts will show a simultaneous targeted quantitative and non-targeted analysis method, with quantitative results down to part-per-trillion levels, for a 250 mL water sample prepared by EPA 1633 protocols. Additionally, non-targeted data is presented for food contact materials and diluted AFFF sample matrices to demonstrate the applicability of the method to solid samples.
Attendees will learn:
<ul>
<li>Why high resolution and accurate mass (HRAM) with LC-Orbitrap instrumentation is a key advantage when trying to precisely describe PFAS components in a sample.</li>
<li>How Thermo Scientific™ Compound Discoverer™ software with a built-in pre-configured PFAS workflow makes it easy to filter for PFAS candidates, and then make identifications based upon extensive compound libraries, fragment databases, and other tools providing a multifaceted approach to exploring unknown PFAS.</li>
<li>How the same HRAM platform provides a solution to both quantify known PFAS and explore unknown PFAS with confidence and convenience, greatly expanding our understanding of this global health and safety concern.</li>
</ul>
<blockquote>
Presenter: Cynthia Grim, M.S. (Product Applications Specialist III, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Cynthia Grim, M.S. is a Product Applications Specialist III in the Environmental and Food Safety Vertical Marketing team. Her previous experience includes secondary metabolite structure elucidation, pharmaceutical drug safety, and environmental testing. Now, her work revolves around developing novel sample preparation and instrument methods for PFAS analysis to prepare for new frontiers in environmental testing across matrix types.
</blockquote>
<blockquote>
Presenter: Richard Cochran, PhD (Senior Application Scientist for LSMS, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Richard Cochran is a Senior Application Scientist for LSMS at Thermo Fisher Scientific, with over 15 years of experience in mass spectrometry, with strong expertise in high resolution mass spectrometry and untargeted analysis. Richard received is PhD in Analytical Chemistry from the University of North Dakota. Prior to joining Thermo Fisher Scientific, Richard was a senior principal investigator within the Center for Aerosol Impacts on Chemistry of the Environment (CAICE, a National Science Foundation Center of Innovation) and served as the director of the Environmental and Complex Analysis Laboratory at the University of California San Diego. Throughout his career he has published more than 20 scientific publications in the area of mass spectrometry, altogether having more than 1,000 citations.
</blockquote>
<blockquote>
Presenter: Ed George (Vertical Marketing Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Ed George has a BS in Chemistry from the University of Notre Dame with concentration in Environmental Science. He worked for 15 years in the environmental laboratory industry, holding positions of Lab Technician, Lab Manager, and R&amp;D Manager, responsible for developing novel sample preparation and analytical methods in soil and water on GC/MS/MS and LC/MS/MS platforms. He participated in several collaborative method development projects with the USEPA. In 2014, he joined Thermo Fisher Scientific and is currently a Senior Applications Scientist. He has worked closely with key collaborators on food safety and environmental projects in universities and industry and has recently developed workflow applications for pesticide and veterinary drug residues in food on both LC/MS/MS and high-resolution MS platforms.
</blockquote>

Thermo Fisher Scientific: LC-Orbitrap MS Workflow for Targeted and Non-Targeted Analysis of over 40,000 PFAS Compounds in Environmental and Food Contact Material Samples

LC-Orbitrap MS Workflow for Targeted and Non-Targeted Analysis of over 40,000 PFAS Compounds in Environmental and Food Contact Material Samples

Simultaneous targeted quantitative and non-targeted PFAS analysis, in 250 mL water sample prepared by EPA 1633 protocols.

LC-Orbitrap for Targeted and Non-Targeted Analysis of PFAS

Regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have established guidelines and requirements regarding extractables and leachables to ensure the safety and quality of pharmaceuticals products. Compliance with these regulations is essential for obtaining regulatory approval and maintaining market access.
Register now and attend this Webinar to learn:
<ol>
<li>Latest trends &amp; applications in E&amp;L analysis
</li>
<li>Advanced LC/HR-MS based workflows and solutions offered by Agilent
</li>
<li>Role of statistical analysis in extractable profiling
</li>
<li>Regulatory landscape in E&amp;L analysis
</li>
<li>Understanding the quantitation approach
</li>
</ol>
<h4>Other webcasts from the series</h4>
<h5><a href="https://gcms.labrulez.com/webinar/3965">USP 467 Residual Solvent: Application Updates Tips &amp; Tricks</a></h5>
<ul>
<li>Thursday, 06 June 2024, 15:00 IST</li>
</ul>
<h5>Advanced GC/MS | GC/HR-MS Based Workflow for Extractable and Leachable Analysis</h5>
<ul>
<li>Thursday, 08 August 2024, 15:00 IST</li>
</ul>
<h5>Demystifying USP &amp; ICHQ3D Guidelines for Elemental Impurities</h5>
<ul>
<li>Thursday, 05 September 2024, 15:00 IST</li>
</ul>
*Register for all the webinars and get complementary access to The experts guide to Pharmaceutical Impurity Analysis e-book.
<blockquote>
Presenter: Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)
</blockquote>
<blockquote>
Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.
</blockquote>
<blockquote>
Presenter: Mr. Praveen Arya (Application Engineer - GC/MS, Agilent Technologies)
</blockquote>
<blockquote>
Praveen Arya, Application Engineer at Agilent technologies, has a commitment and appreciation for Gas-phase residue applications. In 2005, Mr. Praveen Arya completed his M.Sc. in Food Technology . After post-graduation, he served as a Senior Analyst at SGS, Gurgaon- a commercial testing laboratory for 6 years and developed expertise in Residue analysis using sophisticated chromatographic instruments such as LCMS and GCMS. After that, in 2011, He joined Agilent Technologies as an Application Engineer where he supported country-wide GCMS customers for resolving application issues and method development. He has more than 18 years of experience in residue analysis in food and environmental samples using various high end chromatographic and spectrometric techniques (GC, GCMS, GCMS/MS, TDS, Headspace, Purge &amp; trap etc.). His area of specialization includes new analytical method development and validation as per national and international guidelines.
</blockquote>
<blockquote>
Presenter: Mr. Ankush Sharma (Regional Marketing Program Manager- APAC (Pharma &amp; Biopharma), Agilent Technologies)
</blockquote>
<blockquote>
Ankush Sharma is a seasoned professional with over 12 years of extensive experience in sales and marketing across the pharmaceutical and biopharmaceutical sectors. His professional journey commenced with a strong educational foundation, earning a Master&#39;s degree in Biotechnology. Building upon this knowledge, he furthered his academic pursuits by obtaining a Master&#39;s in Business Administration with a specialization in Sales and Marketing, demonstrating his commitment to blending scientific understanding with strategic business acumen. For the past five years, he has been an integral part of Agilent, serving as the Regional Marketing Program Manager for the India and now Asia-Pacific (APAC) region for Pharma and Biopharma Markets.
</blockquote>

Agilent: Advanced LC/HR-MS Based Workflow for Extractable and Leachable Analysis

Advanced LC/HR-MS Based Workflow for Extractable and Leachable Analysis

Latest trends & applications in E&L analysis, advanced LC/HR-MS based workflows and solutions offered by Agilent, and regulatory landscape in E&L analysis

LC/HR-MS Workflow for Extractable and Leachable Analysis

See how RapidFire is accelerating mass spec analyses for High Throughput Screening (HTS), ADME, biopharma, synthetic biology, food, and life sciences laboratories by replacing chromatography with a simple sample cleanup step and producing quality MS results in seconds.
We will discuss the latest developments in the RapidFire technology and how it enables a more productive, efficient, and cost-effective laboratory. Blazing-fast runtimes mean that your lab can eliminate backlog, improve turn-around times, and meet the demands of an ever-increasing number of samples. Improved sample consumption with the ability to use up to 7-fold less material translates to even more cost savings per sample. An increased plate storage capacity, support for 1536-wellplates, and temperature-controlled sample storage increase walk-away time, giving users more time to perform other lab duties. We will explore how labs are leveraging these advances, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.
Key Learnings:
<ul>
<li>See how to generate high quality mass spec data in seconds per sample</li>
<li>Learn strategies for improving lab efficency and productivity</li>
<li>Understand the advantages and limitations of Solid Phase Extraction Mass Spec</li>
</ul>
Who Should Attend:
<ul>
<li>Lab Managers</li>
<li>Lab Analysts</li>
<li>Chemist</li>
<li>Analytical Scientists </li>
<li>Lab Directors</li>
</ul>
<blockquote>
Presenter: Jennifer Hitchcock (Application Scientist, Agilent Technologies)
</blockquote>
<blockquote>
Jennifer is an Application Scientist with Agilent Technologies, developing methods utilizing LC and RapidFire front ends with mass spec detection for clinical and cannabis labs. Prior to joining Agilent in 2015, Jennifer worked as an R&amp;D scientist in a clinical testing lab in North Carolina. In her spare time, Jennifer enjoys spending time with her family in Richmond, Virginia.
</blockquote>
<blockquote>
Presenter: Kevin McCann (Product Manager, Agilent Technologies)
</blockquote>
<blockquote>
Kevin McCann focuses on high-throughput LC/MS solutions at Agilent Technologies in product marketing for RapidFire and StreamSelect. He has also worked as an application scientist, developing and supporting a variety of LC/MS applications.
</blockquote>
<blockquote>
Presenter: Christina Poggel (Product Manager, Wiley)
</blockquote>
<blockquote>
Christina Poggel has been leading the Science and Industry Content Strategy team at Wiley since 2024. Previously, she was Editor-in-Chief for Wiley Analytical Science from 2019, after joining Wiley as an Editor in 2017. Christina Poggel holds an M.Sc. in Chemistry and a Ph.D. in Organometallic Synthesis and Homogeneous Catalysis from Philipps University in Marburg, Germany. In the course of her research, she applied various spectroscopic, chromatographic, and mass spectrometric methods.
</blockquote>

Wiley: Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Preparation

Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Preparation

The latest developments in the RapidFire technology and how it enables a more productive, efficient, and cost-effective laboratory.

Advances in RapidFire-MS Analyses

Rice fortification in India combats nutritional deficiencies, making accurate testing essential. Advanced LC/MS/MS and spectroscopic methods ensure proper vitamin and iron levels, and compliance with food safety standards. With the FSSAI emphasizing fortified foods, rigorous testing aligns with India&#39;s nutritional goals and meets regulatory requirements.
In this live webinar, experts will talk about the essentials of food fortification analysis and help you:
<ul>
<li>Understand India&#39;s regulatory approach and how FSSAI strategies impact rice fortification standards</li>
<li>Discover sample handling and method optimization for high sensitivity and reproducibility</li>
<li>Explore solutions in applying LC/MS/MS and Spectroscopy for rice fortification analysis</li>
</ul>
This webinar is designed for:
<ul>
<li>Food Safety Chemists</li>
<li>Regulatory Affairs Specialists</li>
<li>QA/QC Personnel</li>
<li>Laboratory Managers and Analysts</li>
<li>Academicians and Researchers in Food Safety</li>
</ul>
<blockquote>
Presenter: Dr. Dinesh Kumar, Ph.D. (Assistant Director (Tech), Quality Assurance Division, Food Safety and Standards Authority of India (FSSAI))
</blockquote>
<blockquote>
Dr. Dinesh Kumar is an Assistant Director (Technical/Scientific) in Quality Assurance Division at Food Safety and Standards Authority of India (FSSAI), FDA HQ., New Delhi, India.
</blockquote>
<blockquote>
He has received the his doctorate degree from Indian Institute of Technology Delhi (IIT-D) &amp; All India Institute of Medical Sciences Delhi (AIIMS-D) in “Bio-Medical” and also working in collaboration with the Dana-Farber Cancer Institute, Harvard Medical School, USA on cancer therapeutics and early diagnostics.
</blockquote>
<blockquote>
He received a President award for the best for thesis and also honored by the award of “YOUNG SCIENTIST” by Ministry of Science and Technology (Govt of India).
</blockquote>
<blockquote>
He has good teaching and research experience of more than 10 years. He has published and presented several papers (40+) in peer reviewed National and International Journals and conferences.
</blockquote>
<blockquote>
He has 12 Patents filed so far out of which 10 technologies transferred licensing to industry for commercialization. He has worked on various projects sponsored by DST, SERB, ICMR and ICAR Govt. of India.
</blockquote>
<blockquote>
In Current scenario, He is the Panel Secretariat of Scientific Panel on Methods of Sampling &amp; Analysis along with Rapid Analytical Food Testing (RAFT) Kit/ Equipment/ Method at Food Safety and Standard Authority of India (FSSAI).
</blockquote>
<blockquote>
Presenter: Dr. Komal Chauhan (Dean Research &amp; Outreach | Head - CFRA, CEFF, National Institute of Food Technology Entrepreneurship and Management and Management (NIFTEM-K))
</blockquote>
<blockquote>
Dr. Komal Chauhan had the rare opportunity of being nurtured in varied regions and cultures of India bringing out the best in her. She did her doctorate in Food Science and Nutrition from Banasthali University Rajasthan. A meritorious student throughout her academic career she has been a scholarship holder and Gold Medalist at Masters Level. She embarked on her teaching career from SD College Ambala Cantt and later to Banasthali University. Currently she is working as Professor in Nutrition in the Dept. of Food Science and Technology at National Institute of Food Technology Entrepreneurship and Management, Kundli, Sonipat, Haryana, India. and also holding the charge of Dean Research and Outreach and Head, CEFF, and HEAD CFRA. She has a teaching and research experience of more than two decades.She has published and presented several papers in National and International Journals and conferences. She has been working in the area of Nutraceuticals and Functional Foods and Nutritional Biochemistry. She has been working in the areas of malnutrition, and non-communicable diseases namely diabetes, cardiovascular diseases and obesity. She has worked on various projects sponsored by UNICEF, UGC, DST/SERB/MoFPI and Ministry of Tribal Affairs, MP Govt, WCD Govt. of Kerala.
</blockquote>
<blockquote>
Presenter: Dr. Ramaprasad Ganni (Technical Support Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Dr. Ramprasad has 21 years of experience in the field of Chromatography and Column chemistries. Worked for Elsevier GmbH; Germany, and Millipore India Pvt, Ltd. Presently working with Agilent technologies; India, since 2008 in Chemistries and Supplies division. Responsible for Workflow solutions development, providing technical support, and trainings for various industries of Food, Pharma, Petroleum, Bio-technology. Experienced in developing applications, LC and GC column chemistries and technologies, Sample preparation techniques, method developments and troubleshooting the problems of various chromatography technologies such as LC, GC, Mass Spectrometry, GPC/SEC, and Preparative LC.
</blockquote>
<blockquote>
Presenter: Mr. Vikrant Goel (Application Scientist, Agilent Technologies)
</blockquote>
<blockquote>
Vikrant comes with an extensive 19 years of experience working in QA/QC, R&amp;D and Analytical roles and an expert in various LCMS technologies. His solution-based approach has been well accepted among LCMS fraternity from Pharma and Applied market segments, since 2004. He holds an M.tech in Biotechnology, PG Dip in Bioinformatics &amp; B. Pharm. He joined Agilent in 2010, as a Product specialist for LC/MS, after having worked with ILS Bioservices &amp; LabIndia Instruments. His passion towards solution, brought him back to the Application role, 6 years ago.
</blockquote>

Agilent: Fortification of Rice - An analytical perspective: in association with FSSAI and NIFTEM-K

Fortification of Rice - An analytical perspective: in association with FSSAI and NIFTEM-K

 Advanced LC/MS/MS and spectroscopic methods ensure proper vitamin and iron levels, and compliance with food safety standards.

Fortification of Rice - An analytical perspective

Recent instrumental breakthroughs in mass spectrometry are a real game-changer and have opened new possibilities for proteomic analysis implying extreme sensitivity at high throughput.
On the one hand single cell proteome analysis has become feasible: we have pushed a timsTOF Ultra instrument to its limits to reach a proteome coverage of around 5.000 proteins identified in a single cell. On the other hand, chromatography and MS acquisition parameters optimizations combined with innovative AI-based data interpretation have enabled us to reach unprecedented coverage in immunopeptidomics with close to 20.000 immunopeptides identified from limited numbers of cells. We will show how fine application-specific optimizations of every step of the proteomics workflow are strongly beneficial to the output results.
<blockquote>
Presenter: Christine Carapito (CNRS Research Director, Co-head of the BioOrganic Mass Spectrometry Laboratory, CNRS and University of Strasbourg, France)
</blockquote>
<blockquote>
Presenter: Jeewan Babu Rijal (Post-doctoral fellow at the BioOrganic Mass Spectrometry Laboratory, CNRS and University of Strasbourg, France)
</blockquote>

Bruker: timsTOF Ultra: Immunopeptidomics and single cell proteomics explorations

timsTOF Ultra: Immunopeptidomics and single cell proteomics explorations

Fine application-specific optimizations of every step of the proteomics workflow are strongly beneficial to the output results.

LCMS webinars focusing on LC/MS/MS - page 47