Ask any analytical chemist which hyphenated technique has become indispensable over the past decade, and the answer will almost certainly be the same: tandem chromatography–mass spectrometry. Whether it is <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis">LC–MS/MS</a> quantifying a novel biologic’s metabolic fate, or <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-gc-ms/ms-analysis">GC–MS/MS</a> chasing per- and polyfluoroalkyl substances (PFAS) down to sub-part-per-trillion levels in municipal water, the combination of chromatographic separation with the specificity of tandem mass detection has become the analytical workhorse of choice across virtually every regulated sector.Below we examine the key forces propelling this expansion, from biopharma pipeline dynamics and PFAS regulatory mandates to AI-driven automation and reshoring of pharmaceutical manufacturing—and explore what each trend means for laboratories managing sample preparation and analytical workflows.<h3>Biopharma: The Engine Room of LC–MS/MS Demand</h3><h4>GLP-1 Agonists and the Metabolomics Gold Rush</h4>The explosive commercial and scientific interest in GLP-1 receptor agonists—<a target="_blank" rel="noopener noreferrer" href="https://www.sepscience.com/advancing-glp-1-peptide-analysis-chromatography-challenges-and-innovations-12163">semaglutide and related peptide therapeutics </a>for diabetes and obesity—has dramatically expanded the analytical demands placed on tandem MS platforms. Discovery programs require precise quantification of peptide drug candidates and endogenous biomarkers across complex biological matrices. These workflows rely on high-sensitivity LC–MS/MS for pharmacokinetic profiling, receptor occupancy studies, and metabolomics characterization. Metabolomics is, in fact, projected to be the fastest-growing application segment in mass spectrometry, driven in part by its growing role in cancer screening, biomarker discovery, and metabolic disease research.I have been spending more time learning about GLP-1s because this is the hot topic that people want to discuss on the Concentrating on <a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL?si=n9GLz9zjSCOrVfXPxFPhng&amp;nd=1&amp;dlsi=52868e027aad4d22">Chromatography podcast</a>. With that said, I was astounded looking at CNBC.com during breakfast this morning to see that <a target="_blank" rel="noopener noreferrer" href="https://www.cnbc.com/2026/03/21/glp-1-diets-restaurants-protein-fiber-weight-loss-drugs.html">one in eight Americans are currently taking one of these drugs such as Ozempic</a>.<h4>Antibody–Drug Conjugates and Gene Therapy: Complexity at Every Step</h4>The ascent of antibody–drug conjugates (ADCs) and gene therapies has introduced a new level of analytical complexity. ADCs blend the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads—and characterizing the linker chemistry, drug-to-antibody ratio (DAR), and conjugate stability demands high-resolution LC–MS/MS at every stage from discovery through QC release testing. Gene therapy vectors require equally rigorous characterization of impurities, aggregates, and empty/full capsid ratios.This translates into a direct need for low-evaporation, high-recovery concentration methods that preserve labile protein structures and maintain sample integrity prior to LC–MS/MS injection. <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">Nitrogen evaporation workflows</a> that minimize oxidative stress and maintain sample temperature are increasingly critical in these pipelines.<h4>Precision Medicine and Multi-Omics Integration</h4>The shift toward precision medicine has accelerated adoption of high-throughput, multi-analyte MS platforms. Proteomics, metabolomics, and lipidomics workflows are converging on a single analytical platform—tandem MS—and generating datasets of a scale and complexity that were unimaginable ten years ago.Make no mistake: the triple quadrupole serves an irreplaceable role in quantitative targeted analysis. At the same time, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3">Orbitrap </a>and Q–TOF hybrid platforms are growing rapidly as researchers demand full-scan accurate mass for untargeted discovery.<h3>Environmental Mandates: PFAS Testing Drives Adoption</h3>Environmental testing is something that every person, chemist or not, can understand the importance of. Mounting mandates from the U.S. Environmental Protection Agency and European regulators regarding PFAS—the “forever chemicals” whose extraordinary environmental persistence is matched only by the analytical challenge of detecting them at trace levels—have created immediate, compliance-driven investment in LC–MS/MS infrastructure.<h4>The Regulatory Framework Chemists Need to Know</h4>The EPA has codified a suite of LC–MS/MS-based methods as the analytical standard for PFAS in water and solid matrices:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe">EPA Method 533</a>: Weak anion exchange SPE combined with LC–MS/MS; covers 25 PFAS including short-chain compounds in drinking water.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination">EPA Method 537.1</a>: Reversed-phase SPE followed by LC–MS/MS; covers 18 PFAS including the GenX compound, with method detection limits in the low ng/L range.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/en/solutions/environmental/water-testing/pfas-in-water/us-epa-method-8327?srsltid=AfmBOooCY1pcavj7B1PH-75d3HO4BGDglNlhmyTyrpDY3zvUksMO1dlg">EPA Method 8327</a>: LC–MS/MS for selected PFAS in prepared extracts of aqueous and solid matrices.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633">EPA Draft Method 1633</a>: The emerging benchmark for PFAS in non-aqueous matrices—aqueous, solid, biosolids, and tissue—quantifying up to 40 PFAS.</li></ul>All of these methods designate LC–MS/MS, specifically LC coupled to triple quadrupole or tandem-in-time platforms operating in negative electrospray ionization mode with multiple reaction monitoring (MRM), as the required or recommended analytical technique. PFAS analysis is, at its core, an LC–MS/MS problem.<h4>The Sample Preparation Bottleneck</h4>Chemists who have worked with PFAS methods understand the particular demands they place on sample preparation. The ubiquity of<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/tackling-pfas-contamination-practical-insights-from-epa-537.1-method-development"> PFAS in laboratory materials</a>—PTFE tubing, some SPE sorbents, standard bench supplies—means that blank contamination control is as analytically demanding as the detection itself. EPA 537.1 requires that sample volumes of approximately 250 mL be extracted and reconstituted in as little as 1 mL, creating a 250:1 concentration factor that can expose even trace contamination in the sample processing chain. The installation of a delay column between the LC pump and autosampler to prevent instrument background interference is now standard practice.This is precisely where robust, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5385">inert nitrogen evaporation </a>systems earn their keep. PFAS workflows that use nitrogen-assisted evaporation to concentrate extracts prior to reconstitution benefit from materials that avoid PTFE and other fluoropolymers that can leach PFAS background—a consideration Organomation addresses in its concentration system designs.The analytical community is also moving beyond targeted PFAS analysis. High-resolution accurate mass (HRAM) spectrometry via Orbitrap technology, paired with non-targeted screening workflows, is gaining traction for the identification of the more than 5,000 currently catalogued PFAS compounds and the novel structures that continue to emerge. LC–MS/MS remains the quantitative gold standard; HRAM provides the discovery layer.<h3>Technological Trends Reshaping the LC–MS/MS Workflow</h3><h4>Artificial Intelligence and Automated Data Interpretation</h4>The datasets generated by modern tandem MS platforms—particularly in omics applications—are too large and too complex for conventional manual review. AI-driven spectral deconvolution, automated peak integration, and AI-assisted hypothesis generation are now embedded in the software suites accompanying leading instruments. <a target="_blank" rel="noopener noreferrer" href="https://www.agilent.com/about/newsroom/presrel/2022/17feb-gp22004.html?srsltid=AfmBOop3warRIaEojXM2YyMML6RXfMIDzE-Wm0h-SiKkkocBeeET2m7u">Agilent’s acquisition of Virtual Control’s ACIES </a>software specifically to automate LC–MS and GC–MS data analysis is emblematic of this direction.For laboratory managers, AI integration means smaller specialized teams can operate high-throughput multi-analyte workflows—but it also means that the front-end sample preparation must be even more reproducible, since algorithmic interpretation amplifies inconsistencies introduced upstream.<h4>Online SPE Coupling and “Chromatography Without Walls”</h4>A significant trend is the integration of solid-phase extraction directly into the HPLC flow path—so-called online SPE–HPLC coupling. Systems that combine extraction and chromatographic separation in a single analytical instrument reduce manual transfer steps, minimize the risk of sample loss or contamination, and dramatically increase throughput. For analytes at very low concentrations, online SPE provides the on-column concentration capability that traditional offline preparation achieves with manual evaporation steps.That said, offline sample preparation—including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">nitrogen-assisted evaporation</a> under controlled conditions, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2407">liquid–liquid extraction</a>, and protein precipitation—retains significant advantages in flexibility, matrix handling, and the ability to process sample volumes that exceed online system capacity. The two approaches are increasingly complementary rather than competitive in well-designed analytical laboratories.<h4>High-Purity Solvents and Reference Materials</h4>As detection limits push further into the femtogram range and regulatory methods demand demonstrable blank performance, the quality of analytical consumables—mobile phase solvents, derivatization reagents, reference standards—has moved from background consideration to front-of-mind. Method validation in regulated environments now routinely requires vendor certification of solvent purity at a level that directly interfaces with instrument performance.<h3>The Ever-Present Need for Sample Evaporation</h3>As LC–MS/MS methods push detection limits lower, the analytical burden shifts increasingly upstream. The quality of the concentration, cleanup, and reconstitution steps preceding injection determines whether the instrument’s theoretical sensitivity is achievable in practice.Several specific developments are particularly relevant:<ul><li>ADC and gene therapy characterization workflows require gentle, low-temperature evaporation that preserves protein structure and prevents aggregation prior to LC–MS/MS. Nitrogen evaporation under controlled conditions is the preferred approach.</li><li>PFAS trace analysis demands evaporation systems constructed from PFAS-inert materials, with rigorous attention to avoiding fluoropolymer surfaces throughout the sample path.</li><li>High-throughput pharmaceutical QC driven by reshoring demands parallel processing capability—multi-position evaporators that maintain consistent flow and temperature across all positions simultaneously.</li><li>Multi-omics and metabolomics workflows generate large sample batches that benefit from automated, walk-away evaporation with programmable endpoints to ensure reproducible final volumes across a cohort.</li></ul>Tandem chromatography–mass spectrometry is not merely growing; it is becoming structurally embedded in the analytical workflows of every major regulated industry. The convergence of biopharma complexity, PFAS regulatory mandates, AI-enabled data analysis, and pharmaceutical reshoring is creating a multi-year demand cycle that will require laboratories to invest not only in instruments, but in the entire sample preparation ecosystem that makes those instruments perform.For analytical chemists, the practical takeaway is this: as mass spectrometry sensitivity continues to advance, the sample preparation step becomes the binding constraint on method performance. Whether you are developing a new PFAS method to meet EPA 1633, characterizing an ADC’s drug-to-antibody ratio, or running a 500-sample metabolomics cohort overnight, the reliability and cleanliness of your concentration and cleanup workflow determines the quality of every data point that follows.&nbsp;

The Continued Rise of Tandem Chromatography–Mass Spectrometry

<h3>A Practical Guide to Getting the Most from Syringe Filters: Tips, Tricks, and Common Pitfalls</h3>Syringe filters play a crucial role in chromatography and many other laboratory applications by removing particulate matter before analysis. Proper sample filtration helps protect analytical instruments, extends column lifetime, and improves data quality. However, selecting an unsuitable filter—or using one incorrectly—can introduce contamination, reduce filtration efficiency, or even compromise analytical results. The following recommendations will help you avoid common mistakes and ensure reliable filtration every time.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp" alt="KNAUER: Avoiding Common Syringe Filter Mistakes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp 133w," sizes="100vw" width="1276" height="1496"><h4>1. Improper Filter Handling</h4>Using excessive force during filtration or attempting to reuse disposable syringe filters can damage the membrane and increase the risk of sample contamination.<ul><li>Solution: Apply slow, even pressure throughout the filtration process and always dispose of single-use filters after one use. If the flow rate decreases noticeably, replace the filter instead of applying additional force.</li></ul><h4>2. Selecting an Inappropriate Pore Size</h4>Using the wrong pore size may either fail to remove unwanted particles or cause the membrane to clog prematurely, reducing filtration efficiency.<ul><li>Solution: A 0.45 µm membrane is generally suitable for routine particulate removal, while a 0.22 µm membrane is recommended for finer filtration and bacterial removal. Samples with higher viscosity may require a pre-filter to prevent rapid clogging. It is also important to consider the intended analytical technique. For example, 0.22 µm filters are typically preferred for UHPLC and LC-MS applications, whereas 0.45 µm filters are often sufficient for conventional HPLC analyses.</li></ul><h4>3. Choosing the Wrong Membrane Material</h4>Different membrane materials exhibit different chemical resistance. Using an incompatible membrane may lead to degradation of the filter, sample contamination, or complete filtration failure.<ul><li>Solution: Always verify solvent compatibility before filtration. PTFE membranes are an excellent choice for organic solvents, while PES and nylon membranes are better suited to aqueous samples. If compatibility is uncertain, perform a small-scale trial before filtering valuable samples.</li><li>Pro Tip: For additional guidance, see our blog article "How to Choose the Right Membrane for your Syringe Filter", which provides a detailed comparison of membrane materials and their recommended applications.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg" alt="KNAUER Sepapure® Syringe Filters are available with multiple membrane materials, each identified by a dedicated color code for quick and reliable selection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg 245w," sizes="100vw" width="1580" height="902"><h4>4. Ignoring Filter Capacity</h4>Using a filter with insufficient capacity can result in rapid membrane blockage, increasing filtration time and reducing laboratory productivity.<ul><li>Solution: When filtering larger sample volumes, choose high-capacity syringe filters or introduce a pre-filtration step. Never force liquid through a clogged membrane, as doing so may damage the filter and negatively affect sample quality.</li></ul><h4>5. Overlooking Sample Adsorption</h4>Certain membrane materials may adsorb analytes of interest, leading to lower recoveries and potentially affecting quantitative results.<ul><li>Solution: For protein samples or other adsorption-sensitive analytes, select membranes with low binding characteristics, such as nylon or glass fiber, whenever appropriate. Performing a small recovery test before routine analysis can help identify potential analyte losses.</li></ul><h4>6. Failing to Optimize Filtration Performance</h4>Slow filtration is more than just an inconvenience—it often indicates that the filtration conditions are not optimal.<ul><li>Solution: If filtration becomes unusually slow, investigate possible causes such as membrane clogging, excessive sample viscosity, or an unnecessarily small pore size. Depending on the sample, dilution or sequential filtration using progressively finer filters may significantly improve performance.</li></ul><h4>Final Thoughts</h4>Selecting the appropriate syringe filter is a straightforward process, but overlooking small details can have a significant impact on analytical performance. Choosing the correct membrane material, pore size, and filtration strategy helps improve laboratory efficiency, protects chromatography systems and columns, and contributes to accurate, reproducible analytical results.With the right syringe filter and proper filtration technique, you can minimize sample preparation problems and maximize confidence in every analysis.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg" alt="KNAUER: Sepapure® Syringe Filter Selection" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg 245w," sizes="100vw" width="1160" height="627">Happy filtering!

Avoiding Common Syringe Filter Mistakes

News from LabRulezLCMS Library - Week 27, 2026

Article

Product

Application

Academy

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Agilent Technologies

Thermo Fisher Scientific

Shimadzu Corporation

Waters Corporation

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
In this webinar, there will be a discussion on ways to reduce the instrument background level and how to minimize compound carryover using autosampler’s cleaning parameters options. For the instrument background, step by step instructions will be provided how to clean the entire LC/MS system. For the carryover reduction, suggestions for selecting washing solvents as well as instrument settings for the autosampler settings to minimize compound carrover.
<blockquote>
Presenter: Andre Szczesniewski (Applications Chemist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Andre graduated from University of Illinois in Urbana-Champaign with a master’s degree in Food Science. Working for over 30 years in the instrumentation industry as an applications chemist, Andre has specialized in the development and implementation of LC-MS applications for various industries including clinical research. He has expert knowledge of chromatography (from nano- to preparative-scale) and mass spectrometry with extensive practical knowledge in areas of small and large molecules, quantitation, proteomics, metabolites identification, forensics, clinical, toxicology, food and environmental analysis.
</blockquote>

Agilent Technologies: Reduction of the background level and compound carryover for LC/MS applications

Reduction of the background level and compound carryover for LC/MS applications

Ways to reduce the instrument background level and how to minimize compound carryover using autosampler’s cleaning parameters options.

The background level and carryover for LC/MS applications

Per- and polyfluoroalkyl substances (PFAS) pose an increasing threat to the environment, animals, and human beings due to extreme chemical stability and bioaccumulation potential. PFAS analysis is a complex problem that is best addressed with complementary targeted and non-targeted approaches. A comprehensive workflow was developed for the PFAS analysis in wastewater based on the existing EPA draft Method 1633 with additional PFAS of varying size and functional group. Strategies for sensitivity will also be discussed.
However targeted assays only cover a small fraction of PFAS. Therefore non-targeted methods and software are very important to understand the health risks of PFAS. We introduce our comprehensive software, FluoroMatch suite, which covers peak picking, annotation, homologous series detection, assigning confidence, and PFAS data visualization. We show different workflows which take advantage of Agilent&#39;s iterative exclusion approach, as well as integrate Profinder non-targeted peak picking.
<blockquote>
Presenter: Tarun Anumol, PhD (Director, Global Environment Market, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Tarun Anumol is the Director for Global Environment Market at for Agilent Technologies. Previously, he was an LC-MS applications scientist at Agilent, focused on developing analytical methods for trace contaminants on LC-MS/MS and LC-Q/TOF in food and environmental matrices. Tarun has a strong history of working in the environmental &amp; food testing industry, with a background in technical and applied science, with over 30 peer-reviewed journal publications in this area.
</blockquote>
<blockquote>
Prior to joining Agilent, Tarun graduated with a Ph.D. in Chemical &amp; Environmental Engineering from the University of Arizona with a focus on emerging contaminant attenuation including PPCPs, PFAS and DBPs in water reuse schemes.
</blockquote>
<blockquote>
Presenter: Emily Parry, PhD (LC/MS Applications Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Emily has been with Agilent for four years. Prior to joining Agilent, Emily developed methods for environmental contaminants in a variety of human and environmental matrices using both targeted and untargeted mass spectrometry techniques. She worked as a researcher at the Environmental Protection Agency (EPA) and Public Health Institute. She received her Ph.D. degree in Environmental Chemistry from the University of California, Davis.
</blockquote>
<blockquote>
Presenter: Jeremy Koelmel, PhD (Researcher at Yale University and CEO of Innovative Omics, Innovative Omics and Krystal Pollitt Laboratory, Yale University)
</blockquote>

Unravelling the PFAS puzzle with Comprehensive Targeted & Untargeted Workflows

PFAS analysis is a complex problem that is best addressed with complementary targeted and non-targeted approaches.

PFAS with Comprehensive Targeted & Untargeted Workflows

Join our panel of PFAS experts from across the food and environmental testing arena as we discuss challenges, best practices, solutions, and the future of analyzing these “forever” chemicals. Exploring the global implications of PFAS testing and ever updating regulatory requirements, hear our experts share their experiences and insights. Be sure to engage in the discussion and overcome your analytical challenges by posting your questions to our panel.
Key learning objectives
<ul>
<li>Key considerations in uncovering the right workflow- from sample preparation, detection and quantification- to achieve quality data you can trust now, and into the future.
</li>
<li>Best practices and tips in maintaining reliable and repeatable analysis in the routine laboratory workspace.
</li>
<li>Comprehensive analytical solutions to meet your laboratory’s demands, increase capacity and outperform even the most stringent of PFAS limits currently in place, US EPA Health Advisory Limits.
</li>
</ul>
Who should attend?
Lab Managers, Quality Managers, Technical Managers, Chief Scientific Officers, Lead Scientists who wish to improve their confidence, capabilities and capacity in PFAS testing.
<blockquote>
Presenter: Dr. Kari Organtini (Waters Corporation)
</blockquote>
<blockquote>
Dr. Kari Organtini is part of the food and environmental applications team at Waters, developing applications on LC- and GC- MS/MS for a variety of applications ranging from pesticides to persistent organic pollutants. She is currently the scientific lead for developing PFAS applications. She received her PhD from Penn State University in 2015 where she studied the occurrence of dioxins and furans in fire debris and their implications to first responder health.
</blockquote>
<blockquote>
Presenter: Dr. Stuart Adams (Waters Corporation)
</blockquote>
<blockquote>
Dr. Stuart Adams has been developing methods for the determination of contaminants in food and the environment for over 17 years. Before he moved to Waters in 2018 to focus on application development, he previously worked as a senior analytical chemist at Fera. He now works with customers to understand and help address their analytical challenges with Waters technologies, with a particular interest in PFAS.
</blockquote>
<blockquote>
Presenter: Stuart Oehrle (Waters Corporation)
</blockquote>
<blockquote>
Stuart Oehrle is a field chemist with over 30 years of tenure at Waters and an adjunct instructor for 25+ years at Northern Kentucky University. Stuart obtained his chemistry degree from Northern Kentucky University and did his graduate work at the University of Alabama-Huntsville and University of Cincinnati. Stuart’s primary area of focus is the application of LC and LC-MS/MS. He has worked extensively in the analyses of toxins from cyanobacteria, explosives, and chemical warfare agents. He has published or presented over 70 papers as well as been awarded several patents.
</blockquote>
<blockquote>
Presenter: Dr. Nicole Riddell (Wellington)
</blockquote>
<blockquote>
Nicole is the Quality Manager at Wellington Laboratories Inc. She obtained a PhD in Analytical Chemistry from Orebro University (Sweden) under the supervision of Dr. Bert van Bavel and a Master’s degree in Synthetic Organic Chemistry from the University of Guelph (Canada). Her main responsibilities include Quality Management in support of Wellington’s three ISO accreditations, provision of technical support relating to the use of Wellington’s certified reference standards, and general research project co-ordination. Her multi-disciplinary background allows her to execute these tasks with a unique perspective. Although Nicole provides support for all Wellington product lines she has worked heavily with per- and polyfluoroalkyl substances (PFAS), in both a synthetic and analytical capacity, since she started at Wellington nearly 18 years ago.
</blockquote>
<blockquote>
Presenter: Ken Rosnack (Waters Corporation)
</blockquote>
<blockquote>
Ken Rosnack is a Principal Market Development Manager in the Testing &amp; Lab Services Group for Waters Corporation. His primary focus is within regulated and routine LC-MS/MS environmental market where he is responsible for world-wide strategy implementation and performance. He maintains collaborations within regulatory agencies as well as with global industrial partners. Over his career, Ken has been primary author on numerous publications, been an invited speaker multi-nationally, and has presented at many conferences. He has been involved with MS for the past 40 years.
</blockquote>
<blockquote>
Presenter: Blake Forman (SelectScience)
</blockquote>
<blockquote>
Blake studied chemistry at the University of Surrey, UK, and further went on to study a master’s in chemistry at the University of Southampton, UK. Blake has previously worked in the Medicines and Healthcare Products Regulatory Agency (MHRA) lab at LGC and as a technical sales specialist for Waters. As a member of the Editorial team, he now plays an integral role in shaping the content on SelectScience.
</blockquote>

Waters Corporation: The highs and lows PFAS testing: An expert panel discussion

The highs and lows PFAS testing: An expert panel discussion

Exploring the global implications of PFAS testing and ever updating regulatory requirements, hear our experts share their experiences and insights.

Welcome to Thermo Fisher Scientific’s Powering Productivity in Food and Environmental Testing webinar series!
Productivity and fast turnaround time are crucial capabilities for any contract testing lab analyzing pesticide residues. 
In this webinar, we will discuss the use of UHPLC-MS dual channel chromatography for pesticide residue testing in food- an interesting approach that utilizes two independent pumps and two columns to increase throughput and speed up test turnaround time.
<blockquote>
Preenter: Łukasz Rajski (Product Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Łukasz Rajski works as product application specialist at Thermo Fisher Scientific. He holds a Ph.D. in analytical chemistry. Łukasz has over 10 years of experience in pesticide residue analysis. He is an expert in the development and validation of analytical methods. Dr. Rajski works with advanced mass spectrometry techniques (both high-resolution and triple quadrupole) coupled to ultra-high performance liquid chromatography, high-performance ion chromatography, and gas chromatography. Łukasz Rajski is a co-author of numerous articles published in scientific journals with high impact factor and book chapters dedicated to pesticide residue analysis
</blockquote>

Thermo Scientific: Dual-channel liquid chromatography- an easy way to improve the productivity in contract testing laboratories

Dual-channel liquid chromatography - an easy way to improve the productivity in contract testing laboratories

Use of UHPLC-MS dual channel chromatography for pesticide residue testing in food.

Dual-channel liquid chromatography in testing laboratories

Xylazine is a non-opioid sedative, analgesic and muscle relaxant which is used in veterinary medicine and not approved for human use.
Recently there has been an increase in the number of reports of Xylazine being abused in combination with other drugs of abuse, specifically fentanyl. 
Moreover, criminal drug networks are mass-producing fake pills and falsely marketing them as prescription pills. 
It is important to be able to accurately screen these materials for commonly abused and emerging drugs and confirm the identity of the materials found. 
<ul>
<li>The first part of the webinar will describe two different techniques that can be used for screening and confirmatory analysis of a counterfeit M-30 pill; one using direct ionization MS, and the other using high resolution ToF.
</li>
<li>The second portion of the webinar will describe an alternative comprehensive confirmatory method using triple quadruple mass spectrometry to quantify each compound found in the pill.
</li>
</ul>
<blockquote>
Presenter: Emily Lee (Application Scientist, Forensics, Research &amp; Development, Waters Corporation)
</blockquote>
<blockquote>
Emily Lee is an Application Scientist at Waters Corporation. Emily is part of a global team dedicated to the development of applications and analytical solutions for Forensics and Toxicology. Emily has gained experience in the use of various Waters mass spectrometry technologies for the analysis of forensic and toxicologically relevant analytes. Prior to working at Waters, Emily has experience working in forensic toxicology laboratories, with high sample turnover and fast turnaround times. Emily was involved in many aspects of day-to-day laboratory operations including sample extraction, analysis, method development and validation, analytical troubleshooting, and reporting. Emily also gained a MSc in Forensic Science (Toxicology) at the University of Huddersfield.
</blockquote>
<blockquote>
Presenter: Jane A. Cooper (Principal Application Scientist, Forensics, Research &amp; Development, Waters Corporation)
</blockquote>
<blockquote>
Principal Application Scientist in the Forensic Toxicology section at Waters Corporation, experienced in the generation of technical marketing material to support Waters Field Marketing and Sales activities. Involved in both the preparation and delivery of presentation, illustrating developed applications using Waters technologies at seminars and conferences. Experienced in the use of Waters chromatographic and mass spectrometry technologies, associated data handling, and reporting software.
</blockquote>

Waters Corporation: Xylazine Emergence: Screening and Confirmation of an Extract from a Counterfeit M-30 Pill

Xylazine Emergence: Screening and Confirmation of an Extract from a Counterfeit M-30 Pill

Two different techniques that can be used for screening and confirmatory analysis of a counterfeit M-30 pill.

Xylazine Emergence: Screening and Confirmation of an Extract

Per- and polyfluoroalkyl substances (PFAS) are the subject of significant regulatory action around the world. PFOA and PFOS are both set to be designated as a hazardous substances and needs analytical testing’s for identification and quantitation in food, water and environment. For the purpose of developing and improving the testing of the PFAS for a wide range of monitoring and improved data quality in different matrices.
This Agilent PFAS Seminar brings basics of PFAS, regulatory overview, agilent solutions and support to establish and improve PFAS testing facility for wide scale monitoring and improved data quality in different matrices.
<ul>
<li>Regulatory Overview</li>
<li>Infrastructure requirement for critical and highly sensitive analysis (Instruments)</li>
<li>Consumables needed for reliable results (Columns &amp; Consumables)</li>
<li>Agilent Expertise and LC-TQ based workflow solutions</li>
<li>Developing and accreditation of routine and regulatory PFAS methods</li>
</ul>
<blockquote>
Presenter: Dr. Ramaprasad Ganni (Technical Support Specialist, Agilent Technologies)
</blockquote>
<blockquote>
He has 21 years of experience in the field of Chromatography and Column chemistries. Worked for Elsevier GmbH; Germany, and Millipore India Pvt, Ltd. Presently working with Agilent technologies; India, since 2008 in Chemistries and Supplies division. Responsible for Workflow solutions development, providing technical support, and trainings for various industries of Food, Pharma, Petroleum, Bio-technology. Experienced in developing applications, LC and GC column chemistries and technologies, Sample preparation techniques, method developments and troubleshooting the problems of various chromatography technologies such as LC, GC, Mass Spectrometry, GPC/SEC, and Preparative LC.
</blockquote>
<blockquote>
Presenter: Dr. Prasanth Joseph (Application Engineer - LC/MS, Agilent Technologies)
</blockquote>
<blockquote>
Prasanth joined in Agilent in 2015 as application Engineer for LC-MS/MS and has 19 years of experience in the analytical instrumentation industry, specializes in small molecule applications.Prasanth received his PhD in Environmental Science from Bharathiar University, India. He also has master’s degree in business administration from the University of Buckingham, UK. Prasanth developed many analytical methods in LC-MS/MS to quantify genotoxic impurities in drug substance and products, analysis of extractables and leachables in pharma and food packaging &amp; medical devices and Bioavailability and Bioequivalence (BA/BE) studies in clinical trials. He provided guidance in developing LC-MS workflows for impurity profiling of pharmaceuticals and metabolite identification (MetID) and quantification as a part of ADME/DMPK related studies.
</blockquote>

Agilent Technologies: PFAs Analysis - No more a challenge

PFAs Analysis - No more a challenge

This Agilent PFAS Seminar brings basics of PFAS, regulatory overview, agilent solutions and support to establish and improve PFAS testing facility.

Polar pesticides are the talk of the town.
And we are here to encounter them and provide a breakthrough LC/MS/MS solution to address the challenges associated with them. Attend this The Lab Central premiere to find out more.
<blockquote>
Presenter: Dr. Prasanth Joseph (Application Engineer - LC/MS, Agilent Technologies)
</blockquote>

Agilent Technologies: The Encounter: Polar Pesticides and LC/MS

The Encounter: Polar Pesticides and LC/MS

We are here to encounter them and provide a breakthrough LC/MS/MS solution to address the challenges associated with polar Pesticides.

Polar Pesticides and LC/MS

Per- and polyfluoroalkyl substances (PFAS) are synthetic compounds that have been the focus of research development for targeted quantitation.
PFAS are present in a variety of consumer products as well as firefighting foam that collectively can be introduced into the environment. Due to the chemical structure, these compounds are hard to break down and are therefore labeled as forever chemicals. As such, once PFAS compounds have been introduced into the environment, they can leach from their origin into the environment and have been detected in surface waters, soils, dust, plant tissue, and even in the air. Recently, concerns have escalated not only for understanding the wider environmental impact, but animal and human health have evolved as research has now focused on detecting and quantifying in human plasma and tissue.
The focus of this webinar is to explore the range of sample types examined for routine PFAS detection and quantification. Dr. John Bowden will provide an overview of the challenges non-water matrices presents for extracting and quantifying including finding blanks and validating the workflows. In addition, research will cover new methods to introduce a wide range of PFAS onto UHPLC columns and perform low-level detection and quantification of PFAS in human plasma by LC-MS/MS. The second part of the webinar will focus on targeted PFAS quantitation using the Thermo Scientific™ TSQ Quantis™ Plus mass spectrometers supporting the EPA draft method 1633 which includes sample preparation using solid phase extraction (SPE) prior to LC-MS/MS analysis. The presented workflow will demonstrate key experimental strategies to improve laboratory productivity demonstrating not only effective sample preparation options but the software solutions critical to streamline the data processing to create standard reports.
Key learning objectives: 
<ul>
<li>Evaluation of the PFAS kits on the Thermo Scientific™ Vanquish™ UHPLC systems to minimize background interference to achieve stated LOQs
</li>
<li>Review of new hardware and software components in the Thermo Scientific™ TSQ Plus mass spectrometers to boost PFAS analysis
</li>
<li>Demonstration of Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software designed to manage the entire experiment and provide comprehensive reports to increase laboratory productivity
</li>
</ul>
Who should attend?
<ul>
<li>Laboratories that are contracted for PFAS testing
</li>
<li>Researchers looking for workflows to increase detection and quantitation limits
</li>
<li>Regulatory agencies that are focused on developing new testing methods and requirements for PFAS studies
</li>
<li>Existing Thermo Scientific™ TSQ and Thermo Scientific™ Orbitrap™ mass spectrometer operators who are interested in the next-level performance and productivity with the TSQ Plus mass spectrometer platforms
</li>
</ul>
<blockquote>
Presenter: Dr. John A. Bowden (Assistant Professor, University of Florida, (Gainesville))
</blockquote>
<blockquote>
Dr. Bowden received his B.S. in Chemistry in 2003 and in 2008 received his Ph.D. in Analytical Chemistry both from the University of Florida. John was a Postdoctoral Fellow in the Dept. of Biochemistry and Molecular Biology at St. Louis University from 2009-2011, and then a Postdoctoral Fellow with the National Institute of Standards and Technology in Charleston, S.C. from 2011-2013 and then became a Research Chemist from 2013-2018. In 2018, John joined the University of Florida and has published over 60 journal articles and over 20 focusing on PFAS.
</blockquote>
<blockquote>
Presenter: Kevin J. McHale, Ph.D. (Senior LC-MS Application Scientist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Kevin is a Senior LC-MS Applications Scientist with Thermo Fisher Scientific. Starting his professional career in 1994 with DuPont Merck, Kevin helped implement “walk-up” LC-MS systems supporting synthetic medicinal chemists. In 1997, Kevin left to pursue his Ph.D. in Analytical Chemistry under the direction of Professor Rick Yost at the University of Florida. Kevin’s research focus was studying ion trap fundamentals and developing nano LC-MS/MS techniques. Upon completion in 2002, Kevin joined Thermo Fisher Scientific as an LC-MS Marketing Specialist supporting the Thermo Scientific™ TSQ Quantum™ triple quadrupole mass spectrometer. With over 21 years at Thermo Fisher, Kevin presently specializes in developing methodology for quantitative LC-MS analyses of small organic compounds on the Thermo Scientific™ TSQ and Thermo Scientific™ Orbitrap Exploris™ mass spectrometer product lines.
</blockquote>

Thermo Scientific: Expanding the scope of PFAS screening and quantitation through targeted acquisition – water analysis and beyond

Expanding the scope of PFAS screening and quantitation through targeted acquisition – water analysis and beyond

Explore the range of sample types examined for routine PFAS detection and quantification.

Expanding the scope of PFAS screening and quantitation

Dive into the world of biopharma analysis with us as we cover the essential aspects of oligonucleotides, a group of rapidly advancing drugs that offers promising treatments and holds great potential for personalized medicines.
We will showcase state-of-the-art solutions that support the entire workflow employed by Contract Drug Manufacturing Organizations (CDMOs), from R&amp;D to validation and manufacturing. Get valuable insights into biopharmaceutical drug development and delve into the capabilities of our solutions, including our Nexera XS inert system, LCMS-9050 QTOF, and the latest LabSolutions Insight Biologics software.
Learning Objectives:
<ul>
<li>Introduction to the crucial aspects of oligonucleotides as therapeutics
</li>
<li>Understand the increasingly important role of LCMS in biopharma for manufacturing, QC, and confirmation
</li>
<li>Explore Shimadzu’s latest hardware and software solutions
</li>
</ul>
<blockquote>
Presenter: Neil Loftus (General Manager, Mass Spectrometry Business Unit (Overseas), Shimadzu Corporation)
</blockquote>
<blockquote>
Neil Loftus is an expert in developing new mass spectrometry technologies and innovative data processing workflows to solve complex analytical problems. As the General Manager of the Mass Spectrometry Business Unit (Overseas) at Shimadzu Corporation, he brings a wealth of experience to his current role. Neil&#39;s professional journey began at the London Hospital Medical College, where he focused on academic and pharmaceutical research applications in metabolism and pharmacokinetics. He then continued his work in clinical quantitative bioanalysis and metabolite identification in an industrial setting before transitioning into mass spectrometry. Throughout Neil’s career, he has remained deeply involved in mass spectrometry research and development. His contributions include publishing scientific papers on pharmaceutical metabolite identification and biomarker research, as well as generating new solutions to change the way we think about data and solve problems that matter.
</blockquote>
<blockquote>
Presenter: Max Kosok (Senior Product Specialist (LCMS), Shimadzu (Asia Pacific) Pte Ltd)
</blockquote>
<blockquote>
With more than 14 years of experience, Dr. Kosok is a passionate expert in mass spectrometry. He has received is PhD from National University of Singapore in Biochemistry doing proteomics research on triple negative breast cancer by high resolution LCMS. In 2020, he joined Shimadzu to deliver end-to-end LCMS application solutions for customers. In his current role as a Product Specialist for LCMS and previously as an application chemist, Dr. Kosok has worked with various pharma and biopharma customers. He has supported a multitude of applications from impurity analysis to biomolecule characterization, particularly on Shimadzu’s LCMS QTOF technology.
</blockquote>

Shimadzu: Towards the Future of Biopharma: Insights into Oligonucleotide Therapeutics

Towards the Future of Biopharma: Insights into Oligonucleotide Therapeutics

State-of-the-art solutions that support the entire workflow employed by Contract Drug Manufacturing Organizations (CDMOs).

Insights into Oligonucleotide Therapeutics

The recently unveiled ultra-fast scanning <a href="https://lcms.cz/products/836">Thermo Scientific Orbitrap Astral mass spectrometer</a> is a game-changer for comprehensive proteome coverage and high-throughput biomedical applications.
In this webcast, Dr. Jesper V. Olsen of the University of Copenhagen will describe the capabilities in data-independent acquisition (DIA) mode with narrow quadrupole isolation windows in combination with short LC gradients.
<h5>Register to learn:</h5>
<ul>
<li>Benefits of narrow-window data-independent acquisition (DIA)</li>
<li>How to acquire comprehensive human proteomes within hours</li>
<li>Optimize methods for low input samples, including single cells</li>
</ul>
<blockquote>
Presenter: Jesper V. Olsen Ph.D (Novo Nordisk Foundation, Center for Protein Research, University of Copenhagen)
</blockquote>
<blockquote>
Prof. Jesper Olsen studied analytical chemistry and obtained his Ph.D. in biochemistry and molecular biology at University of Southern Denmark. He was involved in developing high-resolution MS-based proteomics. In 2012, he was promoted to vice director of Novo Nordisk Foundation for Protein Research at University of Copenhagen, and in 2014 full professor.
</blockquote>

Anatech Instruments: Faster Analysis of Human Proteomes Enabled by Narrow-Window Data-Independent Acquisition

Faster Analysis of Human Proteomes Enabled by Narrow-Window Data-Independent Acquisition

The capabilities in data-independent acquisition (DIA) mode with narrow quadrupole isolation windows in combination with short LC gradients.

LCMS webinars focusing on LC/MS/MS - page 65