<p><strong>Tasty beer starts with knowing what’s in your hops. Explore how online SPE makes bitter acid analysis in hops faster and more reliable.</strong></p><h4><strong>How can you detect bitter acid profiles quickly, reliably, and more sustainably?</strong></h4><p>For craft brewers and beer lovers alike, a refreshing experience is all about flavor.</p><p>So how can you achieve the desired bitterness in your beer? The answer is not just about the recipe. Finding the right flavor profile starts with the bitter acids present in the starting hops material.</p><div><div><p>Hops (the heart of your favorite beer) are the source of the brew’s distinctive flavor tied to bitterness and aroma.</p><p>At the molecular level, bitterness is driven by <a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0308814622016338">α- and β-bitter acids</a>, like humulones and lupulones, whose concentrations determine the final sensory profile of the beer (<strong>Figure 1</strong>).</p><p>Accurately characterizing these compounds in each batch allows brewers to unlock the full potential of every variety of hops.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 1. General chemical structure of hop bitter acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg 222w," sizes="100vw" width="700" height="493"></p><p>While conventional analytical methods rely on long, manual sample preparation steps and hazardous solvents, laboratories now strive for greener and more efficient workflows.</p><p>And moving from manual to online sample preparation is one of the easiest ways your lab can reduce waste and — most importantly — improve reliability with automation.</p><h4><strong>Key takeaways</strong></h4><ul><li>Online SPE reduces hands-on work, shortens turnaround time, and supports more sustainable methods by cutting solvent use and eliminating single-use cartridges.</li><li>Automated UHPLC workflows are easier for new users to execute, offering more reproducible quantifications of α- and β-bitter acids in hops.</li><li>Accurate bitter acid profiles help brewers distinguish hop varieties and control flavor with confidence.</li></ul><h4><strong>Comparing offline vs. online solid phase extraction for bitter acid HPLC analysis</strong></h4><p>If you’ve spent long hours in the lab preparing samples for hops analysis, you’re not alone.</p><p>Manual sample preparation often takes the most time in hops analysis, an area where online <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/chromatography-learning-center/chromatography-consumables/sample-prep.html">solid phase extraction</a> (SPE) can make a real difference. Here’s why.</p><p>Manual SPE has a lot of manual steps. Extraction. Cartridge loading. Washing. Elution. And sometimes solvent exchange or reduction. All before your actual analysis begins. This labor-intensive workflow can take up to an hour and depends strongly on operator skillsets, making reproducibility a challenge for new hires.</p><h4><strong>Online SPE analysis provides key benefits like:</strong></h4><ul><li>Hands-off workflow free of cartridges, manifolds, or vacuum steps.</li><li>Column washing and re-equilibration occur in parallel with separation.</li><li>SPE step is complete in just two minutes.</li><li>Minimizes operator-dependent variability.</li><li>Uses less than 8 mL of solvent.</li></ul><p>Let’s explore what this technique looks like in practice.</p><h4><strong>Online SPE for analyzing α- and β-bitter acids in hops standard solutions.</strong></h4><p>Changing your sample preparation from manual to automated isn’t complicated. With the right tools you can fully integrate online SPE with your UHPLC system (<strong>Figure 2</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 2. Schematic workflow for the determination of bitter acids in hops. The process involves clean up and instrumental analysis using the Thermo Scientific Vanquish Online SPE UHPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg 245w," sizes="100vw" width="700" height="323"></p><h4><strong>The process for analyzing a hops standard solution is straightforward:</strong></h4><ol><li>First, extract hop samples with ethanol (a greener alternative to toluene or diethyl ether in conventional methods).</li><li>Inject the extract directly into your instrument for analysis. Bitter acids retain<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1970"><strong> on the SPE column</strong></a> while matrix interferences that can comprise quantitation are removed.</li><li>Next, backflush the SPE column to transfer the analytes to the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/423"><strong> analytical column </strong></a>for separation. While this separation is taking place, the SPE column is washed and re-equilibrated in parallel, keeping the total run time to 15 minutes, with the separation of all six major bitter acids in a single analysis (<strong>Figure 3</strong>).</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 3. UV chromatogram of hop bitter acids in standard solution (1-cohumulone, 2-humulone, 3-adhumulone, 4-colupulone, 5-lupulone, 6-adlupulone)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg 245w," sizes="100vw" width="700" height="347"></p><h4><strong>Online SPE for analyzing α- and β-bitter acids in real hops samples</strong></h4><p>Analytical labs need methods that are accurate and reliable for brewers to develop distinct and reproducible flavor profiles across batches.</p><p>To assess the applicability of online SPE UHPLC methods for hops analysis, we analyzed bitter acid profiles from four species — Sultana, Barbe Rouge, Azacca, and Sabro.</p><p>The concentration of α-acids dominated all samples, while each hops species exhibited distinct profiles in terms of α-acid and β-acid content, making them suitable for different brewing strategies (<strong>Figure 4</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 4. Bitter acid profiles in four different hop species, error bars display SD (n=6). To check method consistency, we measured each hops extract six times. Variation between measurements was low, with relative standard deviation below 3.5 % across all hops species." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg 245w," sizes="100vw" width="700" height="410"></p><ul><li>For testing labs, this process translates into a workflow that is easy to run, fast, and delivers reliable results without added complexity.</li><li>For craft brewers, reliability means clear, trustworthy insights into hops bitter acid profiles, for better hop selection and more precise control of bitterness and flavor in your beer.</li></ul><h4><strong>From carefully procured samples to tasty sips</strong></h4><p>Efficient UHPLC workflows support faster results, less solvent use, and reliable bitterness data for brewers. And online SPE turns those advantages into practical, day-to-day benefits for brewers and labs alike.</p><ul><li>Less hands-on skills required for lab analysts</li><li>Faster results from labs to brewers</li><li>A more sustainable way to work</li><li>Clear insights into hops flavor</li></ul><p>To learn more about the method and see the full application data, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cn_004238_hplc_vanquish_online_spe_bitter_acids_hops_cn004238_na_en_587a5d300b.pdf"><strong>check out our application note today</strong></a>.</p><h4><strong>FAQs</strong></h4><div><div><h5><strong>What are the key compounds in hops analyzed by HPLC?</strong></h5><p>Bitter acids, namely α-acids and β-acids, especially the six major bitter acids (humulones and lupulones) that define hop bitterness and are required for quality control and brewing decisions.</p></div><div><h5><strong>What column types are recommended for hop acid separations?</strong></h5><p>Classical C18 Silica columns are ideal for bitter acids separation. UHPLC compatible columns with particle size ≤ 2 µm boost analysis with higher flow rate, thus shorter analysis time and solvent consumption.</p></div><div><h5><strong>What’s the best workflow for hops analysis?</strong></h5><p>A typical workflow for hop analysis consists of three main steps: extraction of the target compounds, clean-up of co-extracted matrix components, and instrumental analysis by HPLC or UHPLC. To keep this workflow efficient and reproducible, you should minimize manual handling and add in automation when possible. Integrating online SPE into your LC instrument allows sample clean-up to run automatically, reducing hands-on time, solvent use, and variability while delivering faster, more reliable results.</p></div></div><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#UHPLC #Automation</p></blockquote></div></div>

How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors

<p><strong>In the week of June 29, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Insights from an IC specialist: To be suppressed or not suppressed?</strong></h5><ul><li>Tu, 30.6.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6310">Registration</a></li></ul><p>Join Thermo Fisher’s Ask the Experts session to learn how suppressor technology impacts ion chromatography performance, sensitivity, reliability, maintenance, and troubleshooting.</p><h5><strong>2. SCIEX: Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery</strong></h5><ul><li>Tu, 30.6.2026 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6311">Registration</a></li></ul><p>Discover how ZenoTOF high-resolution mass spectrometry is accelerating single-cell proteomics and plasma biomarker discovery through enhanced sensitivity, throughput, and automation.</p><h5><strong>3. Agilent Technologies: Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres</strong></h5><ul><li>Tu, 30.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6052">Registration</a></li></ul><p>This webinar will discuss diffuse transmission and reflection UV/VIS measurements, including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer.</p><h5><strong>4. Waters Corporation: Informatics series #33 Tips, Tricks and Best Practices</strong></h5><ul><li>Th, 2.7.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6315">Registration</a></li></ul><p>This interactive session revisits essential features, shortcuts, and practical techniques in Empower software that can streamline everyday laboratory work and reduce unnecessary effort.</p><h5><strong>5. Waters Corporation: Unlocking Therapeutic Peptide Characterisation (GLP-1RAs) with Cyclic IMS</strong></h5><ul><li>Th, 2.7.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6313">Registration</a></li></ul><p>Discover how cyclic ion mobility spectrometry (cyclic IMS) improves characterization of GLP-1 analogues and therapeutic peptides, supporting development, quality control, and regulatory submissions.</p><h5><strong>6. Agilent Technologies: Spectral Flow Cytometry Masterclass - Session 1</strong></h5><ul><li>Fr, 3.7.2026 07:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6316">Registration</a></li></ul><p>Learn how full-spectrum flow cytometry enables high-dimensional cell analysis. Explore spectral flow technology, experimental design, and applications in immunology, oncology, and vaccine research.</p>

Webinars LabRulezLCMS Week 27/2026

<p><strong>The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;</strong></p><p>There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607"></p><p>A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;</p><h4><strong>Evaluation of measurement procedure performance&nbsp;</strong></h4><p>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;</p><ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"></p><h4><strong>Characterisation of candidate reference materials&nbsp;</strong></h4><p>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;</p><ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4><strong>Other ILCs&nbsp;</strong></h4><p>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).</p>

Interlaboratory comparisons other than proficiency testing

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<h4><strong>OpenLab CDS can control both LC/MS (SQ) and GC/MS (SQ) instruments in your lab.</strong></h4><p>Learn the Data Analysis workflow tips on how to most effectively and efficiently analyze MS-specific data.</p><blockquote><p><strong>Presenter:</strong> Richard Mutkoski (Laboratory Informatics Application Engineer, Agilent Technologies, Inc.)</p><p>Richard Mutkoski has been a field representative for over 27 years for both hardware and software. In his current role as an informatics application engineer, Rich presents technical solutions of the OpenLab suite of products to customers worldwide. Prior to his tenure at Agilent Rich spent 15 years in a variety of pharma QA/QC and R&amp;D positions, providing him a unique understanding of those workflows, bottlenecks, and challenges.</p></blockquote>

Agilent Technologies: Session 4 – OpenLab CDS for MS Data

Session 4 – OpenLab CDS for MS Data

Learn the Data Analysis workflow tips on how to most effectively and efficiently analyze MS-specific data.

<div><div><p><strong>Let's go back to the Basics of Chromatography, Mass Spectrometry, Data Analysis and Trouble-shooting: understanding the importance of the basics will enable you to be more effective in your daily laboratory life.</strong></p><p>This journey started in 2024 and we are now pleased to invite you to join us to go deeper in fundamentals, troubleshooting and application specific topics.</p><h3><strong>EPISODE 8: Proteins &amp; Peptides Analysis</strong></h3><p><strong>What will you learn?</strong></p><ul><li>Learn about the Newest Innovations in Columns and Detection Technologies for Proteins and Peptides</li><li>Discover the waters_connect world of Dedicated Automated Workflows</li></ul><p><strong>What's next?</strong></p><ul><li>Check out the full Webinar Series Episodes List <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/eventRegistration/EventLobbyServlet?target=reg20.jsp&amp;eventid=4817889&amp;sessionid=1&amp;key=B9182AE813B3F8A30217606156F96B75&amp;groupId=5901784&amp;sourcepage=register"><strong>here</strong></a></li></ul><p><strong>Not sure to be able to attend live sessions?&nbsp;</strong></p><ul><li>Register today and watch the webinars on-demand</li></ul><blockquote><p><strong>Presenter: </strong>Antonia Wierzbicki (Principal MS Market Dev Manager, EMEA, Waters Corporation)&nbsp;</p><p>Antonia Wierzbicki is a MS market development manager at Waters working in EMEA. Antonia has BSc in Pharmaceutical Science and a MSc in Cancer Pharmacology. Following several years working as an analytical chemist in drug development roles within both academic labs and contract research organizations, Antonia has more recently spent time working with analytical chemists to provide solutions using cutting edge technologies to meet their needs and requirements, with a specific interest in ultra-sensitive quantitation of small molecules. Antonia is based in Cambridge UK and keen to connectwith like-minded scientists in the field.</p><p><strong>Presenter:&nbsp;</strong>Andrea Gheduzzi (Principal LC Market Dev. Manager, EMEA, Waters Corporation)</p><p>Andrea Gheduzzi, is a principal LC market development manager for EMEA at Waters Corporation. Andrea Gheduzzi has spent more than 30 years in the chromatography field. Across his career he had various roles, service engineer, chromatography lab manager position, and technical manager for chromatography columns. He has mainly been dealing with pharma accounts, also supporting LC method development activities using DoE/QbD approaches. In his previous role as Pharma Business Development Manager at Waters he has further expanded his expertise in AQbD and related applications. Since 2023 he became principal LC market development manager for EMEA and member of the AQbD working party at the EDQM.</p><p><strong>Presenter:&nbsp;</strong>Ben Wilkes (Principal Biologics Market Development Manager, Waters Corporation)</p><p>Since 2022, Ben Wilkes is a Principal Biologics Market Development Manager at Waters where he connects biotech companies with enabling analytical technologies, focusing on liquid chromatography and mass spectrometry. Prior to Waters, Ben worked at Lonza Biologics from 2015 to 2022 as an analytical R&amp;D scientist, supporting all aspects of a products lifecycle with novel analytical methods. He also previously worked at Abzena and Sanofi-Genzyme after graduating from the University of Manchester in 2012</p></blockquote></div></div>

Waters Corporation: Back to Basics Advanced Webinar Series 2025

Back to Basics Advanced - Biologics: Proteins & Peptides

Learn about the Newest Innovations in Columns and Detection Technologies for Proteins and Peptides. Waters_connect world of Dedicated Automated Workflows.

<p><strong>Are you looking to take your SCIEX OS software skills to the next level? Join our comprehensive 4-part "Tips and tricks" webinar series designed to transform your software expertise.</strong></p><h4><strong>What you'll gain:</strong></h4><ul><li>Insider techniques to maximize SCIEX OS software capabilities</li><li>Practical tips from industry experts</li><li>Interactive learning with live Q&amp;A sessions</li><li>No-cost professional development</li></ul><h4><strong>Part 4: Reporting and data export strategies</strong></h4><p>Learn pro-level techniques for creating impactful reports and optimizing data export in SCIEX OS software.</p>

Reporting and data export strategies

Learn pro-level techniques for creating impactful reports and optimizing data export in SCIEX OS software.

<div><h4><strong>Start Your Journey to ASTRA Expertise</strong></h4><p>Join us for the last <strong>5 series</strong> on building the perfect method for light scattering analysis.</p><p>Learn advanced tools and techniques to master ASTRA software, from normalization to DLS with flowing systems.</p><h4><strong>Session Overview:</strong></h4><ul><li><strong>Part 6 of 10</strong> Baselines &amp; Peaks - Best Practices &amp; Navigating Unexpected Chromatograms<ul><li>Thursday, September 11</li></ul></li><li><strong>Part 7 of 10 </strong>Light Scattering Formalisms - Zimm, Mie, Berry, Debye, oh my! When and Why to Use Them<ul><li>Thursday, September 25</li></ul></li><li><strong>Part 8 of 10:</strong> Calculation Uncertainty and Error Analysis: Establishing Meaningful MALS Results<ul><li>Thursday, October 2</li></ul></li><li><strong>Part 9 of 10: </strong>Distribution Analysis &amp; Results Fitting: Advanced Peak Analysis Tools<ul><li>Thursday, October 9</li></ul></li><li><h5><strong>Part 10 of 10: Mass Recovery &amp; Data Exporting: Effective Reporting of Results and Findings</strong></h5><ul><li>Thursday, October 23</li></ul></li></ul><h4><strong>Why Attend:</strong></h4><ul><li>Deepen your understanding of light scattering and ASTRA.</li><li>Gain actionable insights for your lab.</li><li>Interact with our expert, Dr. Christian Ackerschott.<br>&nbsp;</li></ul><blockquote><p><strong>Hosted by:</strong> Dr. Christian Ackerschott</p><p>Dr. Christian Ackerschott studied Chemistry at the University of Cologne and finished with his diploma thesis in Biochemistry. He completed his studies with the PhD thesis “Characterization of Recombinant Flagelliform Spider Silk Proteins” at the Technische Universität München, where AF4-MALS was used as an essential characterization method.</p><p>Since 2007, Christian works at Wyatt Technology as Application Scientist and is now Head of Customer Service. His tasks also include customer trainings in Dernbach and onsite as well as education and training of the local Field Application Scientists.</p></blockquote></div>

Waters Corporation: Interactive Web Series EU – Becoming a SEC-MALS & ASTRA Expert

Becoming a SEC-MALS & ASTRA Expert: Part 10

Wrap up the series with a focus on mass recovery, result reporting, and best practices for exporting data in ASTRA.

Becoming SEC-MALS & ASTRA Expert Part 10

<div><p><strong>Join us for the last 5 series on building the perfect method for light scattering analysis.</strong></p><p><strong>Learn advanced tools and techniques to master ASTRA software, from normalization to DLS with flowing systems.</strong></p><h4><strong>Session Overview:</strong></h4><ul><li><strong>Part 6 of 10: </strong>Building the Perfect Method - Normalization, Alignment, &amp; Inter-Detector Band Broadening Corrections<ul><li>Friday, September 26</li></ul></li><li><strong>Part 7 of 10: </strong>Navigating Sample Parameters – A Close Look at dn/dc and Extinction Coefficients<ul><li>Friday, October 3</li></ul></li><li><strong>Part 8 of 10:</strong> Advanced Characterization Tools for Multi-Component Analytes - Protein Conjugates, AAV, LNP and ADC<ul><li>Friday, October 10</li></ul></li><li><strong>Part 9 of 10: </strong>ASTRA for Particles: When and How to Deploy<ul><li>Friday, October 17</li></ul></li><li><h5><strong>Part 10 of 10: DLS with Flowing Systems – Leveraging Rh and the Burchard-Stockmayer Plot in ASTRA</strong></h5><ul><li>Friday, October 24</li></ul></li></ul><h4><strong>Why Attend:</strong></h4><ul><li>Deepen your understanding of light scattering and ASTRA.</li><li>Gain actionable insights for your lab.</li><li>Interact with our expert, Dr. Andy Meyer.</li></ul><p>The live interactive web series are 100% live sessions, with anonymous Q&amp;A welcome during and after the discussion. Free for all Wyatt customers.</p><blockquote><p><strong>Hosted by:</strong> Dr. Andy Meyer</p><p>Dr. Andy Meyer joined Wyatt Technology in 2001, serving for several years as an Applications Scientist, then as Dean of Wyatt's "Light Scattering University" and as Director of Customer Service &amp; Support. After managing multiple regions in North America, Dr. Meyer is now a Principal Trainer for Waters | Wyatt Technology. As a Wyatt customer, he completed his Ph.D. in Applied Science – Polymer Chemistry from the College of William and Mary in Virginia.</p></blockquote></div>

Waters Corporation: Becoming an ASTRA Expert

Becoming an ASTRA Expert: Part 10

Finish the series by mastering DLS in flow mode. Use Rh and Burchard-Stockmayer plots to unlock insights from SEC-DLS experiments.

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join us for an exciting webinar where we introduce the new mass spectrometry (MS) functionalities in Chromeleon 7.4 software. This session will provide an overview of the latest features and enhancements, along with practical tips and tricks to optimize your MS workflows. Whether you are a seasoned user or new to Chromeleon CDS, this webinar will equip you with the knowledge to leverage the new MS capabilities, streamline your processes, and achieve more accurate results.</strong></p><h5><strong>Key takeaways:</strong></h5><ul><li>Discover the new MS functionalities and enhancements in Chromeleon 7.4 software</li><li>Learn practical tips and tricks for optimizing MS workflows</li><li>Understand how to integrate and configure MS settings for improved performance</li><li>Get answers to your specific questions during the live Q&amp;A session</li></ul><h5><strong>Who should attend:</strong></h5><ul><li>Chromeleon CDS users looking to upgrade their MS capabilities</li><li>Laboratory analysts and technicians working with mass spectrometry</li><li>Quality control and assurance professionals seeking to enhance MS workflows</li><li>Anyone interested in learning more about the new MS features in Chromeleon 7.4 software</li></ul><p><i>Don't miss this opportunity to stay ahead with the latest MS functionalities and optimize your workflows in Chromeleon 7.4. Register now to secure your spot!</i></p><blockquote><p><strong>Presenter: </strong>Kimy Young (Senior Manager, Software Product Specialists, Thermo Fisher Scientific)</p><p>Kimy Young is the Senior Manager of software product specialists at Thermo Fisher Scientific. She has been with Thermo Fisher since November 2015. Her background includes administration of Chromeleon CDS, laboratory information management systems (LIMS), Quality Assurance (QA), and IT projects.</p><p><strong>Presenter: </strong>Juan Carmona (Chromeleon CDS Specialist, Thermo Fisher Scientific)</p><p>Juan Carmona is a Chromeleon Specialist at Thermo Fisher Scientific based out of Pflugerville, TX. He has been with Thermo Fisher Scientific for over 15 years. At Thermo Fisher Scientific, he is currently focusing on expanding the customer base using Chromeleon CDS for small networks and enterprise deployments. Prior to joining this group, he was part of the GC/GCMS Center of Excellence team providing support for the product line.</p><p><strong>Presenter: </strong>Monica Driscoll (Regional Marketing Specialist, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Chromeleon CDS webinar series

Mastering mass spectrometry with Chromeleon CDS: Expert tips and tricks

Discover new MS capabilities in Chromeleon 7.4 and learn how to streamline workflows for better performance. Join the live Q&A with Thermo Fisher experts.

Mastering MS with Chromeleon CDS: Expert tips and tricks

<p><strong>Unlock the full potential of your LC-MS system with Thermo Scientific™ Chromeleon™ software features. This webinar will demonstrate the system suitability test with intelligent run control (SST/IRC) capabilities, which provides a robust framework for maintaining the integrity and reliability of LC-MS datasets. We will showcase this functionality in relation to clinical research and forensic toxicology laboratories, saving precious sample and time for data review.&nbsp;</strong></p><p>By automating the evaluation of critical operational conditions and data processing results, the software enables real-time decision-making to address potential issues, such as carryover and quantification inaccuracies. This not only safeguards the quality of the data but also enhances laboratory efficiency and productivity. The ability to define and execute automated responses to test case outcomes ensures that the LC-MS system operates consistently and within expected parameters, ultimately leading to more accurate and reliable analytical results.</p><p>Don't miss this opportunity to elevate your LC-MS operations and achieve greater precision in your research.</p><h5><strong>Learning Objectives:</strong></h5><ul><li>Discover how Chromeleon software automates the evaluation of critical operation and data processing metrics</li><li>Interpret how automated responses to failed test criteria—such as carryover or inconsistent chromatography—can reduce downtime and improved confidence in the analytical results</li><li>Review practical guidance on configuring and implementing SST/IRC functionality within Chromeleon software</li></ul><blockquote><p><strong>Presenter:</strong> Kimy Young (Senior Manager, Software Product Specialists; Thermo Fisher Scientific)</p><p>Kimy Young is a highly experienced Chromeleon software specialist with over 17 years of expertise. She spent over seven years as a customer and software administrator for the first environmental company to adopt an enterprise Chromeleon solution, followed by eight years as a software sales specialist. Currently, she serves as the Senior Manager of Software Product Specialists. Kimy excels in designing Chromeleon solutions, architectures, and reports, supporting a wide range of industries, including pharma/biopharma, environmental, food and beverage, oil and gas, and manufacturing.</p><p><strong>Presenter: </strong>Dr. Jingshu Guo (Senior Product Applications Specialist; Thermo Fisher Scientific)</p><p>Dr. Jingshu Guo is a trained mass spectrometrist with over 10 years of experience in LC-MS-based qualitative and quantitative analyses of small molecules, nucleosides, peptides, and intact protein. After joining Thermo Fisher Scientific, she worked on the method development, implementation, and optimization in clinical and toxicology-related fields. One of her current focuses is to develop fast quantification methods in small molecules, such as biomarkers, therapeutic drugs, and drugs of abuse in biofluids using LC coupled to triple quadrupole MS or high-resolution MS, and LC-free MS platforms.&nbsp;</p></blockquote>

Thermo Fisher Scientific: Safeguard dataset quality in LC-MS analysis with system suitability testing and intelligent run control (SST/IRC)

Safeguard dataset quality in LC-MS analysis with system suitability testing and intelligent run control (SST/IRC)

Unlock the full potential of your LC-MS system with Thermo Scientific™ Chromeleon™ software features. 

Safeguard dataset quality in LC-MS analysis with SST/IRC

<div><p><strong>Join us for an introduction to KnowItAll's Trendfinder, a new tool that applies Principal Component Analysis (PCA) to reveal hidden patterns in large analytical datasets that traditional analysis misses—all through an intuitive interface that any researcher can use.</strong></p><p>This webinar will quickly familiarize you with basic pattern recognition so that basic chemometric analysis can become part of your routine analytical process.</p><h4><strong>What you’ll learn</strong></h4><h5><strong>Pattern discovery made simple</strong></h5><ul><li>How Trendfinder applies PCA to uncover meaningful patterns in complex datasets</li><li>Working with diverse data types: NMR, IR, MS, Raman, UV-Vis, &amp; chromatography</li></ul><h5><strong>Advanced analysis without the complexity</strong></h5><ul><li>Unknown sample projection for classification and marker compound discovery</li><li>Interactive data mining with clear, actionable visualizations</li><li>Live step-by-step workflow demonstrations</li></ul><h4><strong>Who should attend:</strong></h4><ul><li>Current KnowItAll users ready for advanced pattern analysis</li><li>Researchers with large analytical datasets seeking hidden insights</li><li>Anyone interested in accessible, user-friendly PCA approaches</li></ul><h4><strong>About KnowItAll Software</strong></h4><p>KnowItAll offers a unified, vendor neutral solution for data processing, analysis, searching, and databasing. KnowItAll 2026 has tools for workflows across techniques (IR, Raman, GC-MS, LC-MS, NMR and UV-Vis), as well as tools for structure drawing, report publishing, and more. Combined with Wiley’s high-quality spectral reference library databases, it provides an unparalleled solution for fast, reliable spectral analysis.</p><blockquote><p><strong>Presenter:</strong> Michelle D’Souza, PhD (Product Manager, Software Products, Wiley Science Solutions, Wiley)</p><p>Dr. D’Souza brings years of insight and knowledge in the area of spectral informatics with leadership roles at both Wiley and Bio-Rad Laboratories. In addition to her multiple years as a scientific researcher at Abbott (now AbbVie) and DuPont, she has a Ph.D. in Chemistry from Northern Illinois University and a Masters in Analytical Chemistry from the Chinese Academy of Preventative Medicine. She earned a BS degree from Chemistry Department of Beijing University. &nbsp;</p></blockquote></div>

Wiley: Discover hidden trends in spectral & chromatographic datasets

Discover hidden trends in spectral & chromatographic datasets

Introduction to KnowItAll's Trendfinder, a new tool that applies Principal Component Analysis (PCA) to reveal hidden patterns in large analytical datasets

Hidden trends in spectral & chromatographic datasets

<div><p><strong>As synthetic chemistry evolves, digital tools are becoming essential for accelerating innovation, improving efficiency, and supporting sustainability. This webinar explores how computer-assisted retrosynthesis is reshaping the way chemists design and execute synthetic routes—unlocking new possibilities in both academic and industrial settings.</strong></p><p>Olaf Wiest, Professor of Chemistry at the University of Notre Dame, presents his latest research on strategic retrosynthesis, illustrating how complex natural product synthesis can serve as a foundation for new approaches to challenging molecular architectures.</p><p>Dr. Ewa Gajewska, Head of Product Management, SYNTHIA Retrosynthesis Software, Merck® Retrosynthesis Software, Merck KGaA, Darmstadt, Germany, will provide a hands-on demonstration of SYNTHIA Software, showing how expert-coded rules and AI-driven algorithms can streamline planning, optimize routes, and support green chemistry initiatives.</p><h4><strong>Key learning for attendees:</strong></h4><ul><li>Understand the <strong>strategic value of computer-assisted retrosynthesis</strong> in modern synthetic chemistry.</li><li><strong>Learn how SYNTHIA combines expert knowledge and AI</strong> to accelerate route design and reduce costs.</li><li>Explore <strong>practical applications of SYNTHIA</strong> in academic research, medicinal chemistry, and process development.</li><li>Discover how digital tools can support sustainability goals and inspire new synthetic strategies.</li></ul><p>Don’t miss this opportunity to gain actionable insights and future-ready skills—register now and join the live Q&amp;A with leading experts in computational chemistry.</p><blockquote><p><strong>Presenter:</strong> Prof. Olaf Wiest (Grace-Rupley Professor of Chemistry and Biochemistry, University of Notre Dame)<br>Olaf Wiest received his Dr. rer. nat at the University of Bonn, and did postdoctoral work in computational organic chemistry with Ken Houk at UCLA. He has been a faculty member at the University of Notre Dame since 1996, most recently as the Grace-Rupley Professor.</p><p>He is the director of the NSF Center for Computer Assisted Synthesis which is dedicated to applications of machine learning in organic synthesis.</p><p><strong>Presenter:</strong> Ewa Gajewska (Head of Product Management, SYNTHIA Retrosynthesis Software)</p><p>Dr. Ewa Gajewska is the Head of Product Management at Merck KGaA, Darmstadt, Germany, where she leads the development of SYNTHIA Retrosynthesis Software – a groundbreaking software for computer-assisted synthetic planning. She graduated in biotechnology and chemistry from the Gdansk University of Technology and was a recipient of the Outstanding Achievements Award from Poland’s Minister of Science and Higher Education. In 2020 she received her PhD from the Institute of Organic Chemistry at the Polish Academy of Sciences.</p><p>Her passion for tackling complex scientific challenges within commercial settings and the unique blend of her interdisciplinary skills drive the realization of innovative features of SYNTHIA Retrosynthesis Software.</p></blockquote></div>

Wiley: From Molecular Complexity to Synthetic Simplicity

From Molecular Complexity to Synthetic Simplicity

This webinar explores how computer-assisted retrosynthesis is reshaping the way chemists design and execute synthetic routes

<p><strong>Join us for an insightful webinar on the characterization of RNA-based therapeutics using LC-MS and Thermo Scientific Chromeleon CDS. Learn about our automated intact deconvolution and reporting workflow in Chromeleon that enhances the efficiency and accuracy of RNA therapeutic analysis.</strong></p><p>Oligonucleotides are an emerging powerful class of therapeutic modalities, for which robust and sensitive analytical methods are required. The primary structure of therapeutic RNA-based drugs is seen by regulatory agencies as a critical attribute and must be confirmed and quantified together with the 5′ and 3′ termini fragments and any site-specific modifications, to ensure sufficient quality, safety, and efficacy.</p><h4><strong>What You Will Learn</strong></h4><p><strong>In this webinar, we will showcase</strong>:</p><ul><li>Amine-based ion pair reversed-phase (IPRP) LC coupled to a high-resolution MS and MS/MS method (HRMS) for sensitive characterization of several different single-stranded antisense oligonucleotides (ASOs).</li><li>Evaluation of the applicability of an alternative ion pairing reagent, with moderate hydrophobicity, and the use of a mild ESI source, aiming to reduce the formation of ion pair-adducts and in-source induced impurities.</li><li>Detailed impurity characterization of different therapeutic ASO RNA as well as sequencing of the primary structure of the full-length product (FLP) and impurities and degradation products by MS/MS.</li><li>A new workflow and report setup in Chromeleon that enables an automated and high throughput intact LC-MS workflow for analysis of small oligonucleotides, including ASO RNA.</li></ul><h4><strong>Learning Objectives</strong></h4><ul><li>Learn how to analyze ASO RNA by LC-MS with a fast and sensitive method to confirm identification, purity assessment, as well as to quantify and sequence impurities.</li><li>Understand why high-resolution mass spectrometry is a powerful technique for oligonucleotide characterization, and how MS/MS sequencing of oligonucleotides in BioPharma Finder software can help confirm the identity and sequence of oligonucleotides.</li><li>Discover best practices and tips &amp; tricks for oligonucleotide analysis by LC-MS, including software solutions.</li><li>Learn how to process intact oligonucleotide LC-MS in a compliant and automated high throughput fashion in Chromeleon CDS.</li></ul><p><i>Can't join on the webinar broadcast? Please register anyway to automatically receive the link to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Dr. Silvia Millán Martín (Senior Research Scientist, National Institute for Bioprocessing Research and Training (NIBRT))</p><p>Silvia Millán Martín is a distinguished Senior mass spectrometry specialist at the National Institute for Bioprocessing Research and Training (NIBRT) in Dublin, Ireland. She collaborates with Thermo Fisher Scientific to develop innovative applications for the characterization of biopharmaceuticals. Her work encompasses a broad range of chromatographic techniques, ensuring comprehensive analytical solutions for the scientific and biopharmaceutical industries. Silvia's extensive background in analytical chemistry and her dedication to advancing biopharmaceutical characterization make her a leading expert in her field. Her recent work continues to push the boundaries of mass spectrometry applications, driving forward the capabilities of biopharmaceutical analysis and production.</p><p><strong>Presenter: </strong>Dr. Ulrik H. Mistarz (Application Scientist, Thermo Fisher Scientific)</p><p>Dr. Ulrik Mistarz is a Senior Application Scientist at Thermo Fisher Scientific in Copenhagen, Denmark. He supports a broad range of LC-MS applications with a focus on developing novel workflows for characterization of oligonucleotides, therapeutic proteins, as well as different antibody formats.</p><p>He has a strong interest in improving the throughput and automation of analytical workflows through developing new LC-MS as well as software workflows.Ulrik Mistarz has a PhD from The Department of Pharmacy at the University of Copenhagen and has more than 10 years of experience with pharma/biopharma characterization and analytics. This includes positions in both pharmaceutical and biotech companies working on LC-MS and HPLC application development.</p></blockquote>

Thermo Fisher Scientific: RNA therapeutics characterization with automated LC-MS workflow

RNA therapeutics characterization with automated LC-MS workflow

Join us for a webinar on characterization of RNA-based therapeutics using LC-MS and Thermo Scientific Chromeleon CDS.

LCMS webinars focusing on Software - page 9