2D-LC-MS improves peptide impurity profiling by enabling salt-based eluents, detecting co-eluting isomers, and solving challenges with shifting retention times.

This course shows how to identify unknowns in LCMS analysis employing the NIST MSMS search software. Part 3 discusses basic settings for Thermo Freestyle software and the NIST 2023 Search.

MD-LC-MS advances structural and functional analysis of mAbs, showing how post-translational changes impact FcRn/FcγR binding and antibody therapeutic performance.

This course shows how to identify unknowns in LCMS analysis employing the NIST MSMS search software. Part 2 discusses the alternate methods for processing the data.

This article presents a wealth of resource related to the capabilities and adoption of MAM workflows within the biopharmaceutical industry.

We explore open-source LC×LC-HRMS workflows for non-target screening, highlighting variable selection and curve-resolution to improve trace-level compound detection.

Over four years ago, the nitrosamine crisis shook the pharmaceutical world, and it still remains a hot topic. Since then, more stringent regulations have been put in place.

Part 1A discusses the using the "Nearby Precursor" to easily display a MSMS spectrum associated with an ion in MS.

Ondřej Mikeš works at the RECETOX center as an environmental epidemiologist in the Human Exposure and Risk Assessment group, focusing on external exposures in epidemiological research.

The RECETOX center successfully completed a project funded by GAČR - Alternative Approaches in the Assessment of Male Reproductive Toxicity of Chemical Mixtures Without Animal Testing.