This podcast explores how chromatography (FPLC/SEC) and mass spectrometry support malaria drug discovery, from protein purification and QC to interaction studies and complex sample preparation.

A practical, end-to-end overview of oligonucleotide manufacturing—from solid-phase synthesis to purification, QC, endotoxin removal, and formulation—highlighting scalable, integrated production workflows.

Dwight Stoll explains why chromatography needs big, high-quality retention datasets for AI—how short columns boost throughput, why ratios matter, and why “drifty” phases threaten prediction models.

Interview with Dr. Eamonn Clark on WRRC water research, fuel-spill impacts, PFAS workflows, and how DIY tools like a homebuilt nitrogen evaporator can expand low-resource labs.

Jim Averso explains why syringe filtration is critical for chromatography, how to choose membranes and pore sizes, avoid common mistakes, cut backpressure, and streamline sample prep with prefiltration.

KnowItAll 2026.1 maintenance release brings LC-MS deconvolution improvements, updated DEA rulebases, and bug fixes to enhance spectral analysis workflows and performance.

How can high-resolution mass spectrometry reveal hidden organometallic intermediates? Learn how HRMS enabled mechanistic insights into palladium catalysis and off-cycle species formation.

Assistant professor Isaiah Spate explains how HPLC and flash chromatography support sustainable synthetic chemistry—from reaction monitoring to purification—plus projects in mechanochemistry and MOFs.

In-depth interview with Andrea, PhD researcher at the University of Pennsylvania, on PFAS, androgen regulation, environmental toxicology, and advanced HPLC radiochromatography workflows.

Interview with PhD researcher Jess on using ambient ionization mass spectrometry to screen and prioritize novel metabolites, reduce solvent use, and streamline natural product discovery before chromatography.