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Thermo Fisher Scientific
Thermo Fisher Scientific
A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.
Distributor
Thermo Fisher Scientific (EMEA)
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer.
Thermo Scientific Orbitrap Ascend Tribrid Mass SpectrometerBe ready for tomorrow’s most challenging demands. Exceed experimental expectation with the MultiOmics, Structural Biology, and BioPharma Editions of the Thermo Scientific Orbitrap Ascend Editions Tribrid Mass Spectrometer.
Features

Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer

Exceed experimental expectation with the MultiOmics, Structural Biology, and BioPharma Editions of the Thermo Scientific Orbitrap Ascend Editions Tribrid Mass Spectrometer.

With new capabilities for multiplexed quantitative proteomics, native protein characterization, and deep biopharmaceutical analyses, the three new Editions deliver ultimate experimental throughput, versatility, and ease-of-use for your specific needs.

Detect and characterize the most difficult protein complexes and native samples without losing low m/z instrument performance and flexibility with the new Native MS option, including world class Orbitrap detection up to m/z 16,000 and ion isolation in the ion trap and quadrupole up to m/z 8,000, with isolation widths down to m/z 100 and m/z 5, respectively.

Thermo Fisher Scientific: Key innovations for Thermo Scientific Orbitrap Ascend Tribrid Mass SpectrometerThermo Fisher Scientific: Key innovations for Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer

Orbitrap Ascend Editions Tribrid MS

  • Orbitrap Ascend MultiOmics Tribrid MS: Discover more from comprehensive metabolomics to proteomics.
  • Orbitrap Ascend Structural Biology Tribrid MS: Take advantage of ultimate versatility for native protein characterization.
  • Orbitrap Ascend BioPharma Tribrid MS: Successfully characterize your most complex biotherapeutics.

Introducing the Orbitrap Ascend Editions Tribrid MS

Eliminate the guesswork from your purchase decision with the MultiOmics, BioPharma, and Structural Biology Editions of the Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer. Simplify your decisions and streamline your research with a tailored configuration for your unique application space.

Employ cutting edge native structural and biopharmaceutical analyses with multiple fragmentation and ion manipulation techniques. With the new Native MS option, detect protein complexes up to m/z 16,000 in the Orbitrap mass analyzer and isolate proteoforms up to m/z 8,000 with an isolation width as low as m/z 5 in the quadrupole.

Quantify more peptides, identify more proteins, confidently assign more labile-PTMs, and discover more previously undetectable protein complexes. Characterize proteoforms and modified compounds with more precision than ever before. 

System highlights

Spend less time on instrument set-up and focus on your science

With the integrated Auto-Ready ion source, trigger on-demand or scheduled system calibrations remotely and without disruption to your LC-MS system.

Gain increased characterization from lipids to intact proteins to oligonucleotides with orthogonal fragmentation  

The Orbitrap Ascend Editions mass spectrometers have multiple fragmentation techniques that provide complementary information.

  • Standard collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD) can be used for multiple analytes.
  • Optional electron transfer dissociation (ETD) increases coverage for proteins and glycopeptide experiments, and ultraviolet photodissociation (UVPD) benefits protein, oligonucleotide, and lipid analysis.
Study the largest protein complexes using native MS techniques, all on the same system as bottom-up proteomics techniques

The Native MS option comprises the extension of the Orbitrap mass range to m/z 16,000, ion trap ion isolation up to 8,000 with MSn capabilities, and more sensitive and selective extended quadrupole isolation up to m/z 8,000. With the Native MS option, you can detect large protein complexes and characterize the subunits by multiple fragmentation techniques.

Environmentally friendly dry pumps decrease energy usage and maintenance

By changing the fore pumps from oil-based to a dry pump, we reduce the heat output by 22%. They also eliminate the production of oil vapors and the need for oil checks and changes, lowering maintenance.

The Orbitrap Ascend Editions mass spectrometers have also received the ACT label, the standard for determining the environmental impact of laboratory products to help labs make informed, sustainable purchasing decisions.

Software solutions for your application

Streamlined instrument control software across all next-generation Thermo Scientific platforms for ease-of-use through different systems. Edition-specific application templates are ready to use and built into the method editor so you can get meaningful results faster.

Thermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - The most versatile platform for deep untargeted and accurate targeted metabolomicsThermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - The most versatile platform for deep untargeted and accurate targeted metabolomics

Orbitrap Ascend MultiOmics Tribrid MS

Benefit from experimental throughput, versatility, and ease-of-use. With industry leading capabilities, the Thermo Scientific Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer delivers ultimate data quality. Quantify more samples at lower concentrations using intelligent acquisition and faster Real-Time Search.

Applications
  • The most versatile platform for deep untargeted and accurate targeted metabolomics
  • The most versatile platform for deep untargeted and accurate targeted metabolomics
  • The most versatile platform for deep untargeted and accurate targeted metabolomics
  • The most versatile platform for deep untargeted and accurate targeted metabolomics
  • The most versatile platform for deep untargeted and accurate targeted metabolomics
  • Lipidomics experiments benefit from AqcuireX software and alternative fragmentation capabilities

Orbitrap Ascend Structural Biology Tribrid MS

Be prepared for tomorrow's challenges in structural analysis with this powerful solution. Achieve greater coverage and explore different ion manipulation options with an expanded m/z range and multiple fragmentation options.

  • Characterize complex molecules (Native MS option) with a recommended mass range up to m/z 16,000 and an extended quadrupole isolation range of up to m/z 8,000.
  • Take advantage of multiple fragmentation options (ETD, EThcD, UVPD) and Proton-Transfer Charge Reduction to achieve comprehensive sequence coverage of your protein target.
Applications
  • Native MS option facilitates the identification of membrane proteins by top-down MS 
  • Utilizing PTCR for complex mixture analysis enables more identification across the m/z range  
  • Crosslinking experimentation is aided by Real-Time Library Search available on the Orbitrap Ascend Structural Biology MS  
  • Comprehensive disulfide bond mapping analysis using FAIMS and EThcD
  • Characterize larger proteoforms by top-down proteomics
  • Characterize larger proteoforms by top-down proteomics
  • Native MS option extends ion detection of large protein complexes

Thermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - Lipidomics experiments benefit from AqcuireX software and alternative fragmentation capabilitiesThermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - Lipidomics experiments benefit from AqcuireX software and alternative fragmentation capabilities

Orbitrap Ascend BioPharma Tribrid MS

Elevate your analytical capabilities and successfully characterize your most complex products from peptides to native protein characterization with the Thermo Scientific Orbitrap Ascend BioPharma Tribrid Mass Spectrometer.  Achieve greater coverage for oligonucleotide sequences and analyze even the largest and most complex molecules.

  • Recommended alternate fragmentation techniques enable detailed structural elucidation.
  • Automated Auto-Ready ion source and application-specific pre-built method templates streamline instrument setup.
Applications
  • Comprehensive native analysis of complex therapeutic proteins using Native MS option and PTCR
  • Comprehensively characterize antibody-drug conjugates combining orthogonal fragmentation techniques
  • Enhanced speed and sensitivity for high sequence coverage and low abundant PTM identifications in peptide mapping experiments
  • Improved sensitivity allows highly confident identification of ppb Host Cell Proteins at analytical flow rates
  • Characterize intact sgRNA up to 100 base pairs using low-q CID fragmentation
  • Unparalleled characterization of low-abundant modifications in oligonucleotides

 

Manufacturer
Thermo Fisher Scientific
Thermo Fisher Scientific
A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.
Distributor
Thermo Fisher Scientific (EMEA)
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer.
 

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