<p><strong>At MSACL 2025, a Thermo Fisher Scientific–sponsored workshop led by Qin Fu addressed one of the most persistent challenges in proteomics: how to efficiently and reproducibly translate biomarker discoveries into clinically meaningful assays. Drawing on experience spanning academia and industry—including prior work in Jennifer Van Eyk’s lab—Fu shared practical insights into building a scalable, end-to-end biomarker discovery-to-validation pipeline.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg" alt="Thermo Fisher Scientific: Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg 245w," sizes="100vw" width="1024" height="512"></p><p>The session highlighted how emerging mass spectrometry technologies, automation, and informatics are reshaping biomarker research—reducing complexity, improving reproducibility, and accelerating the path to clinical utility.</p><h3><strong>The three tiers of biomarker assays</strong></h3><p>The workshop opened with a review of the widely accepted three-tier framework that guides biomarker development from early discovery through clinical validation:</p><h4><strong>Tier 3 – discovery</strong></h4><p>Exploratory, untargeted workflows such as data-dependent acquisition (DDA) and data-independent acquisition (DIA). These approaches prioritize breadth, enabling the identification of large-magnitude biological changes across hundreds to thousands of analytes, typically with low-to-moderate precision and without internal standards.</p><h4><strong>Tier 2 – verification</strong></h4><p>Research-grade targeted assays, including parallel reaction monitoring (PRM) and multiple reaction monitoring (MRM). These methods focus on tens to hundreds of analytes, delivering improved precision and repeatability to confirm trends observed during discovery.</p><h4><strong>Tier 1 – validation</strong></h4><p>Clinically validated assays designed to meet rigorous quality and regulatory standards. These workflows incorporate internal standards and strict quality controls to ensure quantitative reproducibility suitable for clinical and translational use.</p><p>Each tier represents a critical step toward ensuring that biomarker candidates can ultimately deliver reliable patient benefit.</p><h3><strong>The central challenge: from sample to signal</strong></h3><p>Reliable biomarker development depends on consistency across the entire analytical workflow—from biological sample preparation to mass spectrometry data acquisition and downstream analysis. Every step introduces potential sources of variability, and minimizing this analytical noise while preserving biological signal is essential.</p><p>Automation emerged as a central theme of the workshop. Beyond improving throughput, automation fundamentally enhances reproducibility. Robotic sample preparation reduces variability associated with digestion, pipetting, and handling—enabling consistent performance across hundreds or thousands of samples, a scale that is difficult to achieve manually.</p><h3><strong>Technological innovation powering a paradigm shift</strong></h3><p>Recent advances in mass spectrometry are enabling researchers to bridge the gap between discovery and validation more efficiently than ever before. The workshop highlighted several Thermo Fisher Scientific platforms driving this shift:</p><ul><li><strong>Thermo Scientific Orbitrap Astral mass spectrometer</strong><br>Optimized for discovery workflows, the Astral system delivers rapid acquisition and deep proteome coverage while maintaining high precision across large cohorts.</li><li><strong>Thermo Scientific Stellar platform</strong><br>Designed for high-throughput targeted quantification, the Stellar platform supports scalable PRM workflows. Features such as PRM Conductor enable adaptive retention time tracking, which is essential for robust performance in large studies.</li><li><strong>Thermo Scientific OptaSpray Ion Source (under evaluation)</strong><br>A hands-free ionization source designed to deliver consistent spray performance with simplified maintenance, supporting reproducibility across thousands of injections.</li></ul><p>Together, these technologies create a smoother continuum across assay tiers, shortening timelines and reducing barriers to clinical translation.</p><h3><strong>Case study: Inflammatory bowel disease (IBD) cohort</strong></h3><p>A key highlight of the presentation was a large-scale biomarker study in inflammatory bowel disease (IBD). The team conducted a 500-sample discovery analysis, followed by validation in a 1,000-sample cohort. Discovery was performed using the Orbitrap Astral system, while targeted validation employed the Stellar platform.</p><p>This integrated approach successfully confirmed established biomarkers such as C-reactive protein (CRP) while also identifying novel protein candidates with strong translational potential. Importantly, these markers demonstrated consistency across discovery and validation data sets—underscoring the power of advanced instrumentation combined with robust workflows and informatics.</p><h3><strong>From high quantity to high quality</strong></h3><p>Historically, biomarker discovery has involved a tradeoff between throughput and data quality. The workshop demonstrated that this compromise is no longer necessary. By integrating automated sample preparation, optimized informatics, and next-generation mass spectrometry, researchers can now generate high-quality, high-throughput data that is both scalable and reproducible.</p><p>This shift enables faster discovery while increasing confidence that candidate biomarkers are ready for downstream validation and clinical follow-up.</p><h3><strong>The future of biomarker translation</strong></h3><p>The workshop concluded on an optimistic note. Innovations in proteomics are fundamentally transforming biomarker development—shortening timelines, reducing costs, and accelerating the transition from discovery to clinical application.</p><p>By integrating platforms such as Orbitrap Astral, Stellar, and OptaSpray, Thermo Fisher Scientific is helping advance a new era of translational biomarker science—where precision, scalability, and reliability work together to deliver meaningful clinical impact.</p><p><i>Watch the full workshop recording to </i><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk"><i>explore the data, workflows, and results behind this end-to-end approach to biomarker discovery and validation.</i></a></p><h3><strong>Intended use disclaimer</strong></h3><p>General Laboratory Equipment – Not For Diagnostic Procedures.<br>Thermo Scientific general laboratory equipment, consumables, and software are intended for research, academic, and industrial use only. These products are not designed, validated, or approved for in vitro diagnostic or clinical use. Use of these products for diagnostic purposes may result in inaccurate results and potential health and safety risks.</p><h3><strong>Resources</strong></h3><p><strong>Workshop &amp; educational content</strong></p><ul><li>MSACL 2025 workshop recording: <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk"><i><strong>Accelerating Biomarker Discovery and Validation</strong></i></a></li><li>Other MSACL workshop recordings <i>coming soon</i></li></ul><p><strong>Thermo Fisher Scientific Product Pages</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2207"><strong>Thermo Scientific TSQ Certis Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/836"><strong>Thermo Scientific Orbitrap Astral Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1149"><strong>Thermo Scientific Stellar Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/B51004132">Thermo Scientific OptaSpray Ion Source</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs.html">Mass spectrometer affordability programs</a> (Refurbished MS, trade-in, financing/ leasing)</li></ul><p><strong>Peer-Reviewed Literature</strong></p><ul><li>Baker ES et al. <a target="_blank" rel="noopener noreferrer" href="https://europepmc.org/article/MED/22943415"><i>Mass spectrometry for translational proteomics: progress and clinical implications.</i></a> Genome Medicine (2012).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/clinchem/article/62/1/198/5611803"><i>An Empirical Approach to Signature Peptide Choice for Selected Reaction Monitoring.</i></a> Clinical Chemistry (2016).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/mas.21750"><i>Automated proteomic sample preparation: The key component for high throughput and quantitative mass spectrometry analysis.</i></a> Mass Spectrometry Reviews (2023).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.jproteome.7b00623"><i>Highly Reproducible Automated Proteomics Sample Preparation Workflow for Quantitative Mass Spectrometry.</i></a> Journal of Proteome Research (2018).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202409446"><i>A Proteomics Pipeline for Generating Clinical Grade Biomarker Candidates from DIA-MS Discovery.</i></a> Angewandte Chemie International Edition (2024).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202507610"><i>Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort.</i></a> Angewandte Chemie International Edition (2025).</li></ul><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#Omics #BiomarkerDiscovery #MassSpectrometry #ClinicalResearch</p></blockquote>

Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility

<p><strong>Interlaboratory comparisons (ILCs) have been used for more than a century and many important concepts are linked to them. This leaflet addresses the basic terminology of ILCs, why some colloquial terms can be misleading or misunderstood, and the importance of harmonisation.&nbsp;</strong></p><p>An ‘ILC’ is the <i>organisation, performance and evaluation of measurements or tests on the same or similar items by two or more laboratories in accordance with predetermined conditions</i> [1]. ILCs have a variety of overall – and detailed – objectives, the three most common [2] being:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_3_9993b9fb0f.jpg" alt="Eurachem: Let’s call a PT scheme a PT scheme" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_3_9993b9fb0f.jpg 245w," sizes="100vw" width="1516" height="472"></p><h4><strong>Some comparisons have special names&nbsp;</strong></h4><p>The evaluation of participant (laboratory, organisation or individual) performance is typically referred to as ‘<strong>proficiency testing</strong>’ (PT) or ‘<strong>external quality assessment</strong>’ [1]. When the main objective is evaluating the performance of, for example, a candidate standard method, the ILC is often called a ‘<strong>method performance study</strong>’ or a ‘<strong>collaborative study</strong>’ [2, 3]. The former is quite clear whereas wording such as “<strong>collaborative</strong>” and “<strong>cooperative</strong>” just stresses joint effort. A project aimed at producing a new certified reference material may involve several laboratories conducting analyses on agreed properties [4]. Not surprisingly, this work is sometimes labelled as a ‘<strong>material certification study</strong>’. Special ILCs used to demonstrate measurement capabilities of National Metrology Institutes are called ‘<strong>key comparisons</strong>’, ‘<strong>supplementary comparisons</strong>’, and ‘<strong>pilot studies</strong>’ [5].&nbsp;</p><h4><strong>Some terms can be confusing&nbsp;</strong></h4><p>Other terms for ILCs, including ‘ring test’, ‘round robin’ and ‘circle analysis’, are common in the literature. They have, however, been used for different objectives and different designs and may be ambiguous or understood differently by laboratory staff. The use of these terms may, for example, imply a specific way of distributing the ILC sample. ISO/IEC 17043 uses ‘sequential scheme’, for a PT where a unique item is transferred between the participants and ‘simultaneous scheme’, in which similar items from a batch are distributed simultaneously to the participants [1].&nbsp;</p><p>Terms like ‘<strong>measurement audit</strong>’, ‘<strong>interlaboratory testing scheme</strong>’, ‘<strong>measurement comparison scheme</strong>’, ‘<strong>rapid performance evaluation scheme</strong>’ and ‘<strong>intercalibration</strong>’ may not correctly reflect the category of laboratory involved, or the type of work participants do during the ILC.&nbsp;</p><p>When in 1994 the IUPAC defined and described three major types of ‘interlaboratory studies’, the word ‘study’ was preferred to synonyms such as ‘trial’, ‘exercise’, ‘test’, ‘evaluation’ or ‘check’ [2].</p><h4><strong>Let’s try to harmonise&nbsp;</strong></h4><p>Many laboratory staff are unaware of official terms related to ILCs but recognise the acronym PT and words like ‘ring test’. Ideally, we would use a common scientific language, but harmonisation is time consuming. Terms appear and disappear and definitions change. The same term can be defined differently, even in different international standards. Lack of standards and guidelines in local languages can cause confusion and contribute to spreading of less appropriate terms.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_2_820043ce8b.jpg" alt="Eurachem: Let’s call a PT scheme a PT scheme" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_2_820043ce8b.jpg 234w," sizes="100vw" width="1006" height="671"></p><p>Much confusion can be avoided by clear reference to relevant standards and sectoral guides. ISO/ IEC 17043 [1] and ISO 13528 [6] contain many important concepts related to PT schemes and other ILCs. Some of these are also incorporated into ISO/IEC 17025 [7]. Additional useful, and free, tools are the Eurachem PT Guide [8] and the ISO online browsing platform [9].&nbsp;</p><p>In writing guidance and instructions, remember that the term ‘interlaboratory comparison’ has a broad meaning and can be used for all cases described above. Sometimes this is clear enough for the reader. In other cases, use acknowledged terms that reflect the detailed objective of the ILC. Let’s call a PT scheme a PT scheme!</p>

Let’s call a PT scheme a PT scheme!

<p><span><strong>The countdown is on for one of the world’s leading conferences dedicated to food analysis. The 12th International Symposium on Recent Advances in Food Analysis (RAFA 2026), taking place in Prague from 3–6 November 2026, is approaching two important milestones: the Early Bird registration deadline and the deadline for oral abstract submissions, both ending on 30 June 2026. Researchers, analysts, industry professionals, regulators, and students are encouraged to secure their participation at a reduced registration rate and take advantage of the opportunity to present their latest scientific results to the international food analysis community.</strong></span></p><p><span>RAFA 2026 will once again bring together leading experts from academia, industry, and regulatory organizations to discuss the latest developments in food safety, authenticity, contaminants, non-target screening, PFAS, microplastics, food contact materials, artificial intelligence, and advanced analytical technologies. The preliminary program already features an outstanding lineup of internationally recognized speakers addressing some of the most pressing challenges in modern food analysis and food safety.</span></p><h3><strong>Registration</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://rafa.easyevent.eu/tickets/"><strong>Register to attend RAFA 2026!</strong></a></p><p><strong>Early-bird registration until 30 June, 2026</strong></p></blockquote><p>After successful submission of your registration, you will receive by e-mail (i) an automatic confirmation of receipt indicating the total amount of payment due (either for bank transfer or for on-line payment by card), (ii) login to Member section where you can administrate your profile, submit your abstracts, and from <strong>September 2026</strong> register for satellite events, workshops and seminars. If it will not be delivered within a few minutes after submission of your registration please contact us at <strong>RAFA2026@vscht.cz</strong>.</p><p>As soon as payment of registration fee is processed, you will also receive by e-mail (iii) confirmation of payment.</p><h4><strong>Registration Fees</strong></h4><ul><li><strong>Smart rate (Until 30 June, 2026): </strong>€ 655</li><li><strong>Regular registration (Until 30 September, 2026):</strong> € 855</li><li><strong>Late registration (From 1 October, 2026):</strong> € 955</li><li><strong>Student rate*&nbsp;</strong><ul><li><strong>Until 30 June, 2026: </strong>€ 465</li><li><strong>From 1 July, 2026:</strong> € 605</li></ul></li></ul><p><i>* The proof of student status (e.g. copy of a student identify card) is requested as an attachment of the registration form.</i></p><h5><strong>The regular registration fee will include:</strong></h5><ul><li>Attendance at all scientific sessions, workshops, seminars, vendor seminars and other satellite events</li><li>Access to the poster and exhibition area</li><li>Conference kit (name badge, conference bag, conference documents, certificate of participation, certificate of presentation on request)</li><li>Final programme</li><li>E-Book of Abstracts</li><li>Coffee breaks</li><li>Buffet luncheons</li><li>Welcome drink</li></ul><p>In the registration form you can r<strong>egister free of charge for the welcome drink</strong> and you can also order <strong>ticket(s) for the conference dinner (€ 85).</strong></p><p><i>Please note that your registration is firm when your payment has been received.</i></p><h3><strong>Abstract submission</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://rafa.easyevent.eu/tickets/"><strong>Submit your ABSTRACT HERE!</strong></a></p><p>In order to submit an abstract, you must <strong>first register to attend RAFA 2026</strong>. <strong>After registration</strong> you will receive an <strong>access to the Member section </strong>where you can <strong>submit your abstract(s).</strong></p></blockquote><p>&nbsp;After successful submission of your abstract you will receive an automatic confirmation of receipt of submitted abstract via e-mail. If it will not be delivered within a few minutes after submission of your abstract please check at first your spam box-mail and then contact us at <strong>RAFA2026@vscht.cz</strong>.</p><p>Please ensure that your abstract does not contain spelling, grammatical or scientific errors. Even though modifications of your submitted abstract will be allowed in the Abstract section of the Member section until the deadline for the abstract submission, please be confident on the lack of errors in your final version prior to starting the submission process.</p><p>The abstract will be reproduced exactly as submitted. No proofreading will be done, although some corrections may be requested by the reviewers.</p><p>If you need to withdraw your abstract, a written statement reflecting the reasons for this decision must be sent to <strong>RAFA2026@vscht.cz</strong> no later than <strong>September 30, 2026</strong>.</p><h4><strong>Important notice:</strong></h4><blockquote><p><strong>1 registered participant can submit no more than 2 abstracts.</strong></p></blockquote><p>To apply for a young scientist’s oral presentation, as an indication please respect the rule that you should be born in 1991 or later.</p><p>The <strong>text of the abstract </strong>should be<strong> limited to 3000 characters including spaces</strong>. Tables and pictures are not allowed.</p><p><strong>Abstracts of oral presentations and posters</strong> will be included into the "<strong>e-Book of Abstracts</strong>" only after receipt of the conference registration fee. Any payment of the registration fee has to be received until <strong>September 30, 2026</strong>, otherwise contribution(s) will not be included into the e-Book of Abstracts and the Conference programme.</p><h3><strong>Program</strong></h3><h4><strong>Invited Speakers</strong></h4><h5><strong>Food allergen risk assessment: Past, present, future</strong></h5><ul><li>Ben Remington from Remington Consulting Group B.V., Utrecht, the Netherlands &amp; University of Nebraska, USA</li></ul><p>Food allergy and allergen management are global public health issues, and consumer protection depends on transparent and trustworthy labelling. While 30 years of scientific advances show that low level exposures, or reference doses, are unlikely to trigger reactions in most allergic individuals, harmonized and globally aligned regulations are still needed to promote consistent allergen risk assessment and labelling decisions. This presentation will discuss the landscape of allergen risk assessment, global policy developments, current research and future needs in the area.</p><h5><strong>Unmasking hidden adulteration in honey: Strategies for detecting and characterizing honeys produced from sugar-fed colonies</strong></h5><ul><li>Oscar Nuñez Burcio from University of Barcelona, Barcelona, Spain</li></ul><p>From hive to jar, not all honey tells the same story. This presentation addresses hidden adulteration associated with sugar-fed bee colonies, highlighting implications for authenticity, production practices, and the need for a more precise characterization of honey to ensure consumer trust.</p><h5><strong>Analytical and toxicological methods for safety of food contact materials</strong></h5><ul><li>Erich Leitner from Graz University of Technology, Institute of Analytical Chemistry and Food Chemistry, Graz, Austria</li></ul><p>Food packaging plays a critical role in protecting and preserving food throughout the supply chain. All packaging materials intended to come into contact with food must comply with strict EU safety rules. Due to increased complexity of packaging solutions, lowering legal limits and increasing numbers of target compounds, we also have to adapt the strategies used to verify and guarantee the safety of these materials.</p><h5><strong>Data-driven strategies to reduce complexity in non-target HRMS analysis of food samples</strong></h5><ul><li>Anneli Kruve from Stockholm University, Stockholm, Sweden</li></ul><p>LC/HRMS based non-target screening can detect hundreds to thousands of chemical features in complex food and environmental samples. Investigating all of these in detail is practically impossible, so which ones to focus on? Novel computational tools developed in computational mass spectrometry allow predicting the toxicity and concentration of the detected chemical features even if these have not yet been fully structurally elucidated. Combining these predictions enables us to focus on the chemical features possessing high risk.</p><h5><strong>Role of AI in the identification of emerging food systems risks</strong></h5><ul><li>Ákos Bernard Jóźwiak from Syreon Research Institute, Budapest, Hungary</li></ul><p>AI-assisted evidence synthesis – spanning curated scientific evidence, exposome data, and network analysis – is the backbone of next-generation emerging chemical food safety risk identification, enabling earlier signals and more resilient surveillance systems.</p><h5><strong>Challenges of microplastics analysis in the context of food safety</strong></h5><ul><li>Dorte Herzke from Norwegian Institute of Public Health, Oslo, Norway</li></ul><p>Food and food packaging are major sources of micro- and nanoplastic exposure. Plastics used in processing, storage, and packaging can release particles through heat, abrasion, and degradation. Small particles below 2 µm may cross gut barriers and carry chemicals, highlighting the need for robust and sensitive measurement methods.</p><h5><strong>Never-ending analytical challenges in PFAS analysis of food</strong></h5><ul><li>Darina Dvořáková from University of Chemistry and Technology Prague, Prague, Czechia</li></ul><p>Exploring and monitoring PFAS in food requires advanced strategies. Combining targeted, suspect, and non-target HRMS analysis, determination of total fluorine and sum parameters, and novel sensors provides new insights into PFAS occurrence and supports food safety monitoring.</p><h5><strong>An overview of the latest scientific knowledge on process contaminants in food for appropriate risk management measures</strong></h5><ul><li>Thierry Delatour from Nestlé Research, Lausanne, Switzerland.</li></ul><p>Recent scientific findings related to acrylamide and furans formation, occurrence and analytical methods in food provide important insights for risk management.</p>

Deadline for RAFA 2026 Early Registration and Oral Abstract Submission is approaching

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RAFA provides an overview of contemporary trends in ANALYTICAL & BIOANALYTICAL STRATEGIES IN FOOD QUALITY AND SAFETY CONTROL and discusses CHALLENGES / NOVEL APPROACHES IN FOOD AND NATURAL PRODUCTS ANALYSIS.

Recent Advances in Food Analysis (RAFA)

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Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

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The result is more gaussian peaks, reduced chromatographic coelution, and superior spectral quality.</span></p><figure class="image"><img style="aspect-ratio:1291/1172;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg" alt="Waters ACQUITY PREMIER Solution: Improve spectral quality and analyte identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg 171w," sizes="100vw" width="1291" height="1172"></figure><h3><span><strong>Global Services: Committed to your success</strong></span></h3><p data-pm-slice="1 1 []"><span>As part of the ACQUITY Premier experience, one of our applications specialists will work with you to ensure you are getting everything you need from your system. We have a flexible range of support plans to ensure you get the most out of your system:</span></p><h4><span><strong>FlexChoice™ MySystem Coverage&nbsp;</strong></span></h4><p><span>Choose the support you need – no more, no less. The Waters service team offers personalized and flexible support, maintenance, and service options to meet your unique lab requirements.</span></p><h4><span><strong>Compliance Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Simplify your process of validating, qualifying, and record-keeping with consulting services to help meet your regulatory guidelines.</span></p><h4><span><strong>Professional Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Waters comprehensive suite of consultative services, software applications, and analytical business tools guide you on your path to increased efficiencies and lower costs.</span></p><h4><span><strong>FlexUp™ Technology Renewal Program</strong></span></h4><p data-pm-slice="1 1 []"><span>Benefit from ongoing seamless upgrades to our latest LC and mass spec instrumentation and software and eliminate the issues associated with older instrumentation.</span></p><p><span>*Coming soon to all regions.</span></p><h3><span><strong>Informatics: Get more from your data for more trusted decisions</strong></span></h3><p><span>Capture, manage, integrate, and analyze your LC and MS data with our informatics platforms, improving discovery and manufacturing, quality and integrity, and reducing time to market. Easily and seamlessly conduct scientific searches, integrate networks, manage compliance, and streamline operations.</span></p><h4><span><strong>Empower™ Chromatography Data System</strong></span></h4><p data-pm-slice="1 1 []"><span>Your entire laboratory operates better with Empower Software, which makes it easier than ever to run samples and produce meaningful results, all while ensuring adherence to strict compliance requirements.</span></p><h4><span><strong>MassLynx™ Software</strong></span></h4><p data-pm-slice="1 1 []"><span>Increase laboratory productivity with Waters MassLynx™ Software, which simplifies interaction with and improves your MS system with an intuitive interface, intelligent instrument control, and software features built around the focus of your analysis - the sample.</span></p><h4><span><strong>Unifi™</strong></span></h4><p data-pm-slice="1 1 []"><span>Merges LC and high-performance MS data into a single solution, providing organizations with the flexibility to deploy UNIFI-based systems within regulated and non-regulated laboratory environments.</span><br><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg" alt="Waters ACQUITY PREMIER Solution " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Waters ACQUITY UPLC H-Class PLUS System

Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution.

<div><div><h4><strong>Performance that advances your lab</strong></h4></div></div><div><div><p><strong>Whether your goal is to rapidly develop new methods or to routinely analyze large numbers of incoming samples, the ACQUITY UPLC H-Class PLUS System can help you decrease the time to result, while increasing the depth and quality of information received from your sample analysis.</strong></p><p>With the ACQUITY UPLC H-Class PLUS System, you can improve laboratory productivity by transitioning methods to UPLC/UHPLC technology, improve the characterization of your most complex samples through enhanced resolution and leverage advanced tools to simplify and streamline your method development workflow.</p><div><div><div><div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution. The system provides on-demand solvent blending and support for any analytical LC column, making it an ideal choice for modernizing existing or developing new methods." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div><ul><li><strong>Get the flexibility of multi-solvent blending</strong> - Blend up to nine solvents with integrated solvent-select valve with the Quaternary Solvent Manager&nbsp;</li><li><strong>Deliver precise and accurate binary solvent blending</strong> - Blend up to four solvents with integrated solvent-select valve with the Binary Solvent Manager</li><li><strong>Get high-precision injections with direct inject sampling&nbsp;</strong>- The needle-in-flow path design ensures an accurate needle seal at high pressure</li><li><strong>Get accurate temperature control across the entire column</strong> - Configurable for 1 to 6 columns with active preheating</li><li><strong>Automate the formulation of mobile phases</strong> - Significantly reduce the time you spend in the prep lab with&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"> Auto•Blend Plus </a>Technology</li><li><strong>Transfer methods more easily</strong> - Easily adjust for system volume differences when transferring methods from an alternative LC system without alteration to the method table using Gradient SmartStart </li><li><strong>Wide software support</strong> – ACQUITY UPLC H-Class PLUS System is supported by  <strong>Empower, MassLynx, UNIFI</strong>, and several 3rd party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Improving laboratory productivity by transitioning methods to UPLC technology.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: A highly reliable and robust LC-MS system without any compromise in speed, resolution, or sensitivity, especially in everyday settings. The ACQUITY H-Class PLUS Binary System combines an optimized flow path resistant to clogging, stable high-pressure gradient formation, and support for sub-2-µm to 5-µm particle columns to deliver the ideal choice for reproducible everyday LC-MS analyses with any tandem quad or Q-ToF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div><div><div><h3><strong>Discover the UPLC difference</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS System</strong> is the next evolution of ultra-performance instrumentation, providing the <strong>high resolution</strong> of a <strong>quaternary or binary liquid chromatography (LC) system</strong>.</p><p>Achieving <strong>true UPLC performance</strong> requires that system dispersion (or extra-column band spread) be matched to the peak widths associated with narrow bore columns packed with <strong>sub-2-μm particles</strong>. While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the <strong>sharp peaks of UPLC performance</strong> and the <strong>ACQUITY UPLC H-Class PLUS System</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Comparison of the same method with the same column on a low-dispersion ACQUITY UPLC H-Class PLUS System versus a higher-dispersion UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg 245w," sizes="100vw" width="1024" height="555"></p></div></div><div><div><h3><strong>Take your methods to the next level</strong></h3><p>Leverage the benefits of <strong>UPLC technology</strong> to improve your existing <strong>HPLC methods</strong>. By scaling your methods to UPLC, your laboratory will benefit from the combination of <strong>increased resolution, sensitivity, and speed</strong> that comes with modern small particle chemistries.</p><p>Designed to accommodate all of your LC method needs, the <strong>ACQUITY UPLC H-Class PLUS System</strong> is ideally suited to <strong>future-proof your laboratory</strong>, enabling the support of existing HPLC methods now, and provide <strong>significant productivity and cost benefit</strong> when utilized for UPLC methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: The USP analysis of diclazuril and organic impurities was scaled from HPLC to UHPLC to UPLC. The UPLC method resulted in a 4x reduction in run time and a 10x reduction in solvent consumption resulting in improved sample throughput and reduced cost per analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg 245w," sizes="100vw" width="1024" height="613"></p></div></div><div><div><h3><strong>Discover the best method for the best results</strong></h3><p>Get the <strong>versatility</strong> to discover the best set of chromatographic conditions for your sample, providing a <strong>more robust method</strong>. The flexibility of the <strong>ACQUITY UPLC H-Class PLUS Quaternary System</strong> allows you to <strong>automatically screen important method parameters</strong>, including:</p><ul><li>Up to <strong>six columns</strong> in independently temperature-controlled compartments</li><li>pH and ionic strength with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"><strong>Auto•Blend Plus</strong></a><strong> Technology</strong></li><li><strong>Optional and integrated solvent selection valve</strong> expands access to six additional mobile phase lines&nbsp;</li><li><strong>11 unique gradient profiles</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: (A) Auto·Blend Plus method gradient table for trastuzumab pH optimization. (B) pH optimization on trastuzumab charge variants separation. Gradient: 20 mM MES buffer, 50–155 mM NaCl in 15 min." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg 245w," sizes="100vw" width="1024" height="622"></p></div></div><div><div><h3><strong>Deliver greater speed and precision for routine analyses</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> combines the <strong>proven reliability and performance</strong> of the H-Class PLUS System with the <strong>precision and lowest system volume</strong> offered by our <strong>high-pressure mixing binary solvent manager</strong>, allowing you to:</p><ul><li>Accommodate the <strong>most challenging sample matrices</strong></li><li>Tackle applications with <strong>long shallow gradients</strong></li><li><strong>Improve the throughput</strong> of your methods</li></ul><p><strong>Combine </strong>the capabilities of the <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> with <strong>Waters </strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Tandem-Quadrupole-%28-Triple-Quadrupole-%29-Mass-Spectrometry/nav.htm?cid=134656172"><strong>Tandem quadruple technology</strong></a><strong> </strong>for routine quantitative UPLC-MS/MS applications, so you can confidently quantify and trace components in the most complex of samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Direct transfer without a gradient delay offers the opportunity for method improvement with the analysis time going from 5 minutes to 3 minutes representing a 40% reduction in runtime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg 245w," sizes="100vw" width="1024" height="600"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 15,000 psi</li><li><strong>pH range</strong>: 1–12.5 (<i><span>For specific test conditions, contact your Waters sales representative)</span></i></li><li><strong>Operating flow rate range</strong>: Up to 2.2 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: ≤0.002% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary, Quaternary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 6 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications</strong> <strong>(QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div></div></div></div></div>

Waters ACQUITY UPLC I-Class PLUS System

With the ACQUITY UPLC I-Class PLUS System, your lab can achieve highly efficient, rapid separations from ultra-low dispersion and delay volume.

<div><div><h4><strong>Complex chromatography challenges, solved</strong></h4></div></div><div><div><p><strong>Looking for answers to the most complex scientific challenges is what you do, and the scientific tools you deploy and the information they provide can make all the difference. With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS System provides new possibilities for maximizing the resolution and sensitivity of your methods, enhancing the characterization of your samples, and improving productivity to advance the science of your laboratory.</strong></p><div><div><div><div><p>With the <strong>ACQUITY UPLC I-Class PLUS System</strong>, your lab can achieve <strong>highly efficient, rapid separations</strong> from <strong>ultra-low dispersion and delay volume</strong>. The system enables your lab to get <strong>narrow, ultra-efficient peaks</strong>, enhancing the <strong>sensitivity of any mass spectrometer</strong> and simplifying the characterization of the most complex sample.</p><ul><li><strong>Achieve precise and accurate binary solvent blending</strong> with the Binary Solvent Manager, ideal for up to four solvents with integrated solvent-select valve</li><li><strong>Get sample injection versatility</strong>, depending upon your application with the flow-through needle and fixed loop injector options</li><li><strong>Manage ultra-low carryover</strong> through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers</li><li><strong>Get accurate temperature control</strong> across the entire column, configurable for 1 to 2 columns with active preheating</li><li><strong>Improve the performance of any mass spectrometer</strong> with the highest chromatographic resolution which minimizes interference from co-elutions</li><li><strong>Minimize the time and cost</strong> associated with annual qualification with the Waters Empower-based automated system qualification tool (SQT)</li><li><strong>Supported by Empower, Masslynx, UNIFI</strong>, and several third-party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p><strong>Enhance the characterization of your samples</strong>, while <strong>improving productivity</strong> to advance the science of your laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: ACQUITY UPLC I-Class PLUS System FTN-H PDA angled." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg 245w," sizes="100vw" width="1024" height="637"></p><div><div><div><div><h3><strong>Get a clearer picture of your sample</strong></h3><p>Get improved resolution through <strong>reduced system dispersion</strong> with the <strong>ACQUITY UPLC I-Class PLUS System</strong>, providing separations that can amplify your research.</p><p><strong>Shorten analysis times</strong>, <strong>reduce solvent usage</strong>, and <strong>speed access to the data</strong> you need for critical decisions. Designed to fit into your existing LC workflow, the ACQUITY UPLC I-Class PLUS System provides a <strong>clear view into what lies within the sample</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg 245w," sizes="100vw" width="1024" height="595"></p></div></div></div></div></div></div></div></div><div><div><h3><strong>An inlet that improves the performance of any MS</strong></h3><p>The ACQUITY UPLC I-Class PLUS System is designed specifically for the <strong>rapid pace of laboratories</strong> on the <strong>cutting edge of research</strong> where <strong>LC-MS plays a critical role</strong>.</p><p><strong>With the ACQUITY UPLC I-Class PLUS System, your lab will:</strong></p><ul><li><strong>Improve resolution and ionization efficiency</strong> with narrow peak widths, enhancing <strong>mass spectrometry sensitivity</strong></li><li><strong>Enhance sensitivity</strong> through <strong>industry-leading carryover performance</strong></li><li><strong>Improve sample characterization</strong> through <strong>selective isolation</strong> with multidimensional UPLC configurations</li><li><strong>Achieve exceptionally fast analysis times</strong> with <strong>ultra-low delay volume</strong></li><li><strong>Achieve ultimate peak capacity</strong> with <strong>CORTECS Columns</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg 182w," sizes="100vw" width="1024" height="878"></p></div></div><div><div><h3><strong>Achieve ultimate peak capacity with CORTECS Columns</strong></h3><p>When paired with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/columns/cortecs-columns.html"><strong>CORTECS 1.6 µm solid-core columns</strong></a>, the ACQUITY UPLC I-Class PLUS System enables scientists to achieve new levels of resolution, sensitivity, and chromatographic performance. With <strong>CORTECS Columns</strong> and the ACQUITY UPLC I-Class PLUS System, you can increase resolution for even your toughest samples and get the flexibility and power you need to rapidly separate a wide array of compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg 210w," sizes="100vw" width="1024" height="761"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 18,000 psi</li><li><strong>pH Range</strong>*: 1–12.5</li><li><strong>Operating flow rate range</strong>: Up to 2.0 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: &lt;0.001% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 2 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications (QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div>

Waters ACQUITY Arc LC System

The ACQUITY™ Arc™ System is an all-in-one platform for HPLC and UHPLC, designed for robust method development and seamless transfer between modern LC systems, addressing a wide range of analytical challenges.

<p class="cke-user_style-important"><strong>Built upon a foundation of reliability</strong></p><p data-pm-slice="1 1 []"><strong>The method development process is changing. New regulations, software and analytical technologies are rapidly changing how methods are designed, transferred, and monitored over their lifecycle. An all-in-one platform for HPLC and UHPLC separations, the ACQUITY™ Arc™ System is designed to meet the spectrum of challenges you face from robust method development to seamless transfer between any modern LC systems.</strong></p><p data-pm-slice="1 1 []">With the <strong>ACQUITY Arc System</strong>, you can experience true plug-and-play method compatibility for HPLC and UHPLC separations. Significant productivity gains can be realized by deploying a single LC platform that allows for the efficient transfer, adjustment, and improvement of methods from any LC platform without compromise in method integrity.</p><figure class="image"><img style="aspect-ratio:768/886;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_63246061ea.jpg" alt="Waters ACQUITY Arc System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_63246061ea.jpg 136w," sizes="100vw" width="768" height="886"></figure><p data-pm-slice="1 1 []">Laboratory-driven organizations have relied on Waters for over 60 years to deliver reliable, robust, and reproducible solutions to ensure confidence in their analytical results. With over 100,000 LC systems installed, we understand the significant impact the right technology has on your business, and the implications it has on characterizing the quality and safety of your products.</p><p data-pm-slice="1 1 []">Methods with greater agility, robustness, and capacity for change can help you reduce regulatory burden, risk of failure and costs. Visit <a disabled="true">www.methods.waters.com</a> to learn more about how method life cycle management (MLCM) connects your method today to your method tomorrow.</p><h3><strong>Designed for discovery to routine QC applications</strong></h3><p>The <strong>ACQUITY Arc System</strong> is the only available LC system with regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument. With unrivaled column capacity and Arc Multi-flow path™ technology, the<strong> ACQUITY Arc System</strong> allows you to generate new methods and modernize legacy HPLC methods faster than ever before.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Comprehensive detector portfolio</strong></h4><p>High-performance analytical detectors designed to maximize HPLC and UHPLC performance, delivering exceptional sensitivity and linearity for your assays.</p><p>Photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, and mass detection, including the ACQUITY QDa™ Detector.</p><h4><strong>Gradient SmartStart</strong></h4><p>Automatically manage gradient start time and pre-injection steps to maximize sample throughput. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.</p><h4><strong>Quaternary solvent management</strong></h4><p>Precise and accurate blending of up to four solvents with automated solvent compressibility compensation. Increase solvent flexibility with an optional, integrated solvent select valve, providing access to six additional solvents.</p><h4><strong>Negligible carryover</strong></h4><p>Advanced flow-through needle design minimizes carryover by continuously cleansing the needle during run. User-configurable wash settings provide flexibility to address even the most complex sample matrices.</p><h4><strong>Thermal management options</strong></h4><p>Column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm, with a temperature range of 4 °C to 90 °C. Integrated column selection valve options provide unattended, fast column changeover.</p><h4><strong>Auto•Blend™ Plus Technology</strong></h4><p>Program gradients directly in terms of pH and ionic strength to minimize manual mobile phase preparation, reduce potential for human error, and accelerate method robustness testing for chromatographic methods.</p><h4><strong>Arc Multi-flow path technology</strong></h4><p>Delivers plug-and-play method compatibility with HPLC or UHPLC methods with the flip of a switch.</p><p>Easily replicate or improve established methods by simply selecting between Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention.</p><h4><strong>Column Technology</strong></h4><p>Industry-leading selectivity choices to meet the needs of virtually every LC application.</p><h4><strong>Laboratory Informatics</strong></h4><p>Software control within your existing Empower™ or MassLynx™ infrastructure.</p><h3><strong>Replicate your established methods</strong></h3><p data-pm-slice="1 1 []">The <strong>ACQUITY Arc System</strong>, enabled by unique Arc Multi-flow path technology, easily accepts and replicates methods from any HPLC platform, without compromise.&nbsp;</p><p data-pm-slice="1 1 []">Whether you are trying to replicate an out-of-date HPLC method, transfer methods across the organization, or to contract partners, the <strong>ACQUITY Arc System</strong> gives you ultimate flexibility to reproduce, modernize, and transfer existing methods with ease and greater cost efficiency, while preserving the integrity of your methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg" alt="Waters ACQUITY Arc System: Analysis run on a Vendor X LC system and replicated on the ACQUITY Arc System. Conditions: 15 to 35% B in 3 min, 35 to 95% B in 2 min; Mobile phase A: 0.1% HCOOH in H 2 O, mobile phase B: 0.1% HCOOH in ACN; Flow rate = 2.0 mL/min; Column: XSelect™ CSH C 18 , 4.6 x 150 mm, 5 μm; Temp. = 30 °C; UV@ 260 nm; 10.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg 245w," sizes="100vw" width="1099" height="596"></p><p>Upgrade your laboratory with a versatile, modern LC system that delivers HPLC and UHPLC method compatibility at the flip of a switch.</p><h3><strong>Modernize your methods</strong></h3><p>The United States Pharmacopeia (USP) is championing pharmacopeial harmonization and modernization efforts, and international organizations are following suit. As a result, the USP is encouraging the modernization of older compendial methods to ensure they are fit for purpose.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg" alt="Waters ACQUITY Arc System: Quetiapine fumarate system suitability solution analyzed on the ACQUITY Arc System using HPLC, UHPLC, and UPLC™ column/method conditions for the quetiapine impurity method. Peak identification: (1) quetiapine related compound G, (2) quetiapine related compound B, (3) quetiapine desethoxy, and (4) quetiapine." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg 245w," sizes="100vw" width="1092" height="678"></p><p>Revisions to these guidelines give you more flexibility to modify your existing pharmacopeial methods with modern techniques and technologies, and in some cases avoid revalidation. The <strong>ACQUITY Arc System</strong>, featuring the Waters Columns Calculator, allows you to confidently scale your gradient methods from a 3.5 μm to a 2.5 μm particle, decreasing run times, lowering solvent consumption, and increasing sample throughput.</p><h3><span><strong>Save time. Reduce cost.</strong></span></h3><p data-pm-slice="1 1 []">With the right column, the <strong>ACQUITY Arc System</strong> is the ideal solution to accommodate methods from any LC platform.&nbsp;</p><p data-pm-slice="1 1 []">From concept to production, the transition your product takes through the product development cycle often requires rigorous LC assays to properly characterize and assess its readiness to advance to the next stage. These LC assays are often adapted to accommodate the technology available from one stage to the next, in some cases requiring an adjustment from a smaller particle size (sub-2-μm) to a larger particle size (2.5 μm–5 μm).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System enables the support of HPLC and UHPLC methods on a single platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg 173w," sizes="100vw" width="959" height="860"></p><p>The <strong>ACQUITY Arc System</strong> provides the flexibility to maximize productivity through efficient and rapid 2.5 μm–2.7 μm UHPLC separations, or to accommodate larger 3.0 μm–5 μm HPLC particles.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg" alt="Waters ACQUITY Arc System: Save time. Reduce cost." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg 245w," sizes="100vw" width="1683" height="469"></p><h3><span><strong>Mitigate your risk</strong></span></h3><p data-pm-slice="1 1 []">With an expanded range of column manager options enabling up to 15-column switching from 4 °C to 90 °C, the <strong>ACQUITY Arc System</strong> will help you significantly reduce the time spent generating robust methods. Equipped with the plug-and-play ACQUITY QDa Mass Detector, the <strong>ACQUITY Arc System</strong> tracks peaks in your method and reveals hidden coelutions of similar analytes, ensuring you have complete confidence in the reliability and reproducibility of your method now and far into the future.</p><h4><strong>Thermal management options</strong></h4><p data-pm-slice="1 1 []">Active and passive pre-heating options available, with up to 15-column switching from 4 °C to 90 °C. Automated monitoring and tracking of column usage with eCord™ technology available with active pre-heating options.</p><h4><strong>Quaternary solvent management</strong></h4><p data-pm-slice="1 1 []">Accelerate your method development with precise and accurate blending of up to four solvents. Increase solvent flexibility with an optional solvent select valve, providing access to six additional solvents.</p><h4><strong>Auto•Blend Plus Technology</strong></h4><p data-pm-slice="1 1 []">Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</p><h4><strong>Comprehensive detector portfolio</strong></h4><p>Diverse portfolio of detectors for method development, method transfer, and routine use.</p><h4><strong>ACQUITY QDa Detector</strong></h4><p>Mass detection built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no adjustments, it easily integrates with your<strong> ACQUITY Arc System.</strong></p><h5><strong>Support</strong></h5><p data-start="0" data-end="175">Empower eLearning modules to help train your lab on Empower 3 and Method Validation. Applications support that’s customized based on your method development needs.</p><h5><strong>Consumables</strong></h5><p data-start="177" data-end="410" data-is-last-node="">Industry-leading selectivity choices to meet the needs of virtually every LC application. Quality Control (QC) Reference Material benchmarks your <strong>ACQUITY Arc System </strong>and enables perfect resolution. Certified clean vials.</p><h5><strong>Laboratory Informatics</strong></h5><p>Software control within your existing Empower or MassLynx infrastructure. Empower 3 Method Validation Manager allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</p><h3><span><strong>Develop methods that stand the test of time</strong></span></h3><p>Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.</p><p>The <strong>ACQUITY Arc System</strong> is fully compatible with the ACQUITY Arc, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram, leaving nothing to chance.</p><ul><li>Confirm the identity of peaks in a separation without injecting standards.</li><li>Identify new peaks in a separation with molecular weight information.&nbsp;</li><li>Detect unresolved peaks and determine if a peak is homogeneously pure.</li><li>Easily track peaks as method conditions are changed.</li></ul><p data-start="272" data-end="600">Using Empower 3 Software and its Custom Calculations and Custom Reporting functions enables you to quickly and automatically evaluate chromatographic data. Configurable reports allow you to choose optimal conditions based on metrics rather than judgment, ensuring a comprehensive assessment of data and best method conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_7_e7ef959203.jpg" alt="Waters ACQUITY Arc System: Method transfer of USP Assay for Fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. Conditions: Mobile phase: 20:80 acetonitrile/ water; Flow rate = 0.5 mL/min; Column: XSelect HSS T3, 4.6 x 150 mm, 3.5 μm; UV@ 260 nm; 20.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_7_e7ef959203.jpg 224w," sizes="100vw" width="939" height="654"></p><h3><strong>Streamline your workflow</strong></h3><div><div data-message-author-role="assistant" data-message-id="7b732be9-0a45-45fb-b585-70a90c1a74d6" dir="auto" data-message-model-slug="gpt-4o"><div><div><p data-start="602" data-end="827">How would you benefit from increased assay consistency between analysts and from lab to lab? What would you gain by accelerating your robustness testing prior to transferring methods to QA/QC?</p><p data-start="829" data-end="1392" data-is-last-node="">Auto•Blend Plus Technology is a novel software tool that extends traditional quaternary solvent blending to permit gradient programming directly in units of pH and ionic strength, providing the ability to vary composition in even the smallest increments of pH (even those differing by 0.1 pH units or less).&nbsp;</p><p data-start="829" data-end="1392" data-is-last-node="">With Auto•Blend Plus, the cumbersome and error-prone approach of manually preparing several pre-mixed mobile phases can now be eliminated with on-demand mobile phase creation, providing significant time savings and improved productivity to the laboratory.</p></div></div></div></div>

Waters Alliance HPLC System

 With its proven performance history, the Alliance HPLC is the industry’s analytical HPLC system of choice, ideally suited for methods development and routine analysis.

<div><div><h4><strong>Reliably achieve quality, compliant data. Every time, in every lab.</strong></h4></div></div><div><div><p><strong>Liquid chromatography (LC) systems must deliver unequivocal results that give you confidence in your scientific and business decisions. Waters LC commitment continues to succeed with the latest Alliance HPLC System – trusted by scientists worldwide for the data to drive informed decisions.</strong></p><div><div><div><div><p>Building on <strong>industry-standard performance and reliability</strong>, the <strong>Alliance HPLC System</strong> provides the <strong>capabilities to meet today’s business challenges</strong>. With its <strong>proven performance history</strong>, the Alliance HPLC is the <strong>industry’s analytical HPLC system of choice</strong>, ideally suited for <strong>methods development and routine analysis</strong>.</p><ul><li>Time-tested, dependable, and robust workhorse for your HPLC separations</li><li>Integrated solvent and sample management with consistent system-to-system performance and high reproducibility</li><li>Simplify your daily LC system start-up with advanced software functionality</li></ul><h5><strong>Recommended Use</strong></h5><p>For standard HPLC workflows where <strong>consistency and compliance</strong> are the highest priorities.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_1_6b63ab6d62/Waters-Alliance-HPLC-System-1.jpg" alt="Waters Alliance HPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_1_6b63ab6d62/thumbnail_Waters-Alliance-HPLC-System-1.jpg 147w," sizes="100vw" width="908" height="961"></p><div><div><h3><strong>Excellence through the years</strong></h3><p>The consistency of the Alliance HPLC System gives you <strong>exceptional confidence in your analytical results</strong>, day-to-day and year-to-year. Get <strong>accurate and reproducible results</strong> with <strong>Waters flagship HPLC technology</strong>, which provides <strong>consistent and reliable performance</strong>. Whether your Alliance HPLC System is newly manufactured, or you're working on one that is several years old, the Alliance HPLC System is a <strong>time-tested, dependable,</strong> and <strong>robust </strong>workhorse for your HPLC separations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_dfafc334c1.jpg" alt="Waters Alliance HPLC System: Comparison of the separation of carbamates using two different Alliance HPLC Systems, manufactured 7 years apart. The results are equivalent." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_dfafc334c1.jpg 245w," sizes="100vw" width="1024" height="532"></p></div></div><div><div><h3><strong>Performance that exceeds your method requirements</strong></h3><p>The <strong>Alliance HPLC System</strong> ensures the <strong>reliability of your results</strong> via <strong>high injection precision</strong> and <strong>repeatable and accurate flow rates</strong>, resulting in <strong>easy peak identification</strong>, <strong>precise quantification</strong>, and <strong>exceptional retention time repeatability</strong>.</p><p>The integrated solvent delivery system features <strong>quaternary blending with a fixed delay volume</strong> for <strong>consistent and predictable results</strong>, regardless of system back pressure. The sample managers’ <strong>flexible injection capabilities</strong> cover a wide injection volume range (up to 2 mL) with <strong>excellent carryover performance</strong>, typically <strong>below 0.005%</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_2_6dab43c365.jpg" alt="Waters Alliance HPLC System: USP method for Budesonide on the Alliance HPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_2_6dab43c365.jpg 245w," sizes="100vw" width="1024" height="580"></p></div></div><div><div><h3><strong>Advancements in column chemistry and mass detection</strong></h3><p>The <strong>Alliance HPLC</strong> can leverage <strong>smaller particle size column chemistry</strong> to improve your laboratory's efficiency. With <strong>CORTECS 2.7 µm particle size columns</strong>, your lab will benefit from <strong>improvements in resolution</strong> and <strong>faster run times</strong> when transferring from a 5 µm size particle chemistry.</p><p>Further <strong>increase confidence in your data</strong> by adding <strong>mass confirmation with the ACQUITY QDa Detector</strong>, which is <strong>simple to use</strong> and can easily integrate into your existing workflow. <strong>Analysis in Empower 3 Software</strong> combines data from <strong>UV/Vis and mass spectrometry (MS)</strong> peaks to give <strong>mass information to each peak</strong> in the separation.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_3_3711671b2e.jpg" alt="Waters Alliance HPLC System: Mass detection with the ACQUITY QDa Detector with UV detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_3_3711671b2e.jpg 245w," sizes="100vw" width="1024" height="550"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_4_bf40981882.jpg" alt="Waters Alliance HPLC System: Mass detection with the ACQUITY QDa Detector with UV detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_4_bf40981882.jpg 240w," sizes="100vw" width="1024" height="666"></p></div></div><div><div><h3><strong>Features and benefits</strong></h3><ul><li><strong>Quaternary solvent blending. </strong>Support isocratic and gradient applications with 11 unique gradient profile curves and blend up to 4 solvents in any proportion with Auto-Blend Technology. Compatible with solvent types such as reversed-phase, normal-phase, GPC, SEC, and IEX.</li><li><strong>Advanced solvent delivery capabilities. </strong>Serial flow path with pulse-free solvent delivery without the use of dampeners. Online solvent degassing and automated solvent compressibility compensation for accurate flow. Integrated seal wash for robust operation with all solvent types is standard.</li><li><strong>Optional, temperature-controlled environment.</strong> House up to 120 vials in an optional, temperature-controlled environment. Achieve low carryover with active and user programmable needle wash. Variable injection volumes from 0.1 to 100 μL standard, and up to 2 mL optional. Support STAT samples and auto-addition.</li><li><strong>Detection and column options. </strong>Get optional column heating, heating/cooling, or column switching capabilities. Detection capabilities include photodiode array, UV/Vis, fluorescence (FLR), refractive index (RI), evaporative light scattering (ELS), electrochemical, conductivity, and mass detection.</li><li><strong>Intuitive interface and software. </strong>Get instant access to system settings through the large LCD screen with simplified daily set-up with SystemPREP. Supports Empower, MassLynx, and 3<sup>rd</sup> party software packages.</li><li><strong>Compliance-ready. </strong>Supports Waters Empower-based automated system qualification tool (SQT), minimizing the time and cost of annual qualification with standards like GMP, GLP, ISO 17025, and USP &lt;1058&gt;.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_2_47fe8951d2/Waters-Alliance-HPLC-System-2.jpg" alt="Waters Alliance HPLC System: Alliance HPLC System provides powerful functionality for all your application needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_2_47fe8951d2/thumbnail_Waters-Alliance-HPLC-System-2.jpg 161w," sizes="100vw" width="903" height="874"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 5,000 psi</li><li><strong>Front panel display</strong>: Easy to use control panel</li><li><strong>Mobile phases</strong>: Up to 4 with Auto-Blend Technology</li><li><strong>Flow rate range</strong>: Up to 10 mL/min</li><li><strong>Sample carryover</strong>: ≤0.0025% (Caffeine) under specified conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Quaternary</li><li><strong>Solvent conditioning</strong>: Vacuum Degas</li><li><strong>Column capacity</strong>: Standard up to 3 columns</li><li><strong>Maximum sample capacity</strong>: 120</li><li><strong>Detector options</strong>:&nbsp;<ul><li>Tunable UV</li><li>Photo Diode Array</li><li>Fluorescence</li><li>Refractive Index</li><li>Evaporative Light Scattering</li><li>Electrochemical</li><li>Conductivity</li><li>Mass Spectrometry</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li></ul></li><li><strong>Physical specifications</strong>:<ul><li><strong>Width:</strong> 45.7 cm (18.0 in.) or 58.4 cm (23.0 in.) with column heater</li><li><strong>Height:</strong> 57.1 cm (22.5 in.)</li><li><strong>Depth:</strong> 57.1 cm (22.5 in.) or 64.8 cm (25.5 in.) with sample heater/cooler</li></ul></li></ul></div></div></div></div></div></div></div></div>

Watrex Streamline binary gradient HPLC system

Watrex Streamline™ binary gradient HPLC system consists of two P1 pumps, static mixer, CT1 column thermostat, PDA1 diode-array detector, AS1 auto-sampler, and Clarity PDA datastation.

<p><strong>Streamline™ binary gradient HPLC system consists of two </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=streamline+p1+pump&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>P1 pumps</strong></a><strong>, static mixer, </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/column-thermostats/streamline-ct1-columm-thermostat/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>CT1 column thermostat</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=pda1&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>PDA1 diode-array detector</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/sampling-devices/autosamplers/streamline-as1-autosampler/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>AS1 auto-sampler</strong></a><strong>, and Clarity PDA datastation.</strong></p><h3><strong>FEATURES</strong></h3><ul><li>Optimized pump mechanics with parallel piston design offers <strong>excellent flow rate accuracy</strong> and <strong>gradient composition</strong> at all solvents ratios</li><li><strong>Variable volume injection range 0.1 - 999.9 μl</strong>, high precision and reproducibility, and low carryover AS1 autosapler</li><li>Excellent signal-to-noise ratio of <strong>the PDA2 detector</strong></li><li>Data acquisition, processing and instrument control is by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><i>Clarity Chromatography Station</i>*</a></li></ul><h3><strong>COMPONENT SPECIFICATION</strong></h3><ul><li>Gradient solvent delivery system <strong>consisting of two P1 HPLC pumps</strong></li></ul><h5><strong>COMPONENT P1 HPLC pumps</strong></h5><ul><li><strong>Flow Rates:</strong> 0,01 ml/min – 9,99 ml/min with step 0.01 ml/min (analytical)</li><li><strong>Flow Rates:</strong> 0,10 ml/min – 40,0 ml/min (preparative)</li><li><strong>Pressure:</strong> 42 MPa/6000 psi (analytical, stainless steel)</li><li><strong>Pressure:</strong> 35 Mpa/5000 psi (analytical, PEEK)</li><li><strong>Pressure:</strong> 10 Mpa/1500 psi (preparative)</li><li><strong>Flow precision:</strong> ± 0,2% RSD @ 1mL/min. and 1,000 psi (analytical)</li><li><strong>Flow accuracy:</strong> ± 1% @ 1mL/min. and 1,000 psi (analytical)</li><li><strong>Pressure accuracy:</strong> ± 2% of full-scale, with 80:20 H2O/IPA @ 1000psi</li><li><strong>Pulsation:</strong> better than ± 0.5% @ 1mL/min. and 1,000 psi (analytical)</li><li><strong>Remote control:</strong> USB</li><li><strong>Remote control:</strong> Start, Stop, Status, Error</li></ul><h5><strong>COMPONENT - PDA1 detector</strong></h5><ul><li><strong>Wetted Materials:</strong> Stainless Steel/ PEEK*, teflon, Glass (*depending on configuration)</li><li><strong>Light Source:</strong> Deuterium Lamp, Tungsten Lamp</li><li><strong>Wavelength Range:</strong> 190 – 720 nm</li><li><strong>Number of Diodes:</strong> 256</li><li><strong>Baseline Noise:</strong> ± 1 x 10-5 AU (@240 nm, 2 sec. risetime)</li><li><strong>Baseline Drift:</strong> less than 3 x 10-4 AU/h</li><li><strong>Wavelength Accuracy:</strong> 0.5 nm</li><li><strong>Mean Pixel Pitch:</strong> 2.2 nm</li><li><strong>Resolution:</strong> 7 nm</li><li><strong>Linearity:</strong> higher than 2.0 AU</li><li><strong>Data Rate:</strong> 1 Hz – 100 Hz</li></ul><h5><strong>COMPONENT - CT1 Column thermostat</strong></h5><ul><li><strong>Temperature range:</strong> 10 °C above ambient temperature to 100 °C</li><li><strong>Temperature accuracy:</strong> max. 0,5 % of actual temperature</li><li><strong>Temperature stability:</strong> RSD &lt; 0,4 %</li><li><strong>Settability:</strong> 0,1 °C</li><li><strong>Internal dimensions:</strong> 320 x 50 x 30 mm (L x W x H)</li><li><strong>Compartment material:</strong> PTFE coated metal</li><li><strong>Compartment connection:</strong> USB</li><li><strong>Control:</strong> build-in color touch panel, datasystem</li></ul><h5><strong>COMPONENT - AS1 autosampler:</strong> X-Y-Z-Operation; motor driven syringe, Capacity: 60 vials, Sample Loop: standard, 20μl, Reproducibility: Fix Volume: &lt; 0.5%, Variable Volume: &lt;1.0%, Carry-over: &lt;0.01% , Programmable wash.</h5><h5><strong>COMPONENT - Clarity™ Chromatography Station:</strong> PDA data acquisition and evaluation, gradient, and autosampler control with pre-set methods for experimental settings. PC Win 10 Professional with LCD monitor .</h5><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SSG101-001</strong> Streamline™ binary HPLC system (Includes P1m+P1s pumps, PDA1 detector, CT1 thermostat, AS1 autosampler, solvent rack, Clarity PC station)</li></ul><h5>Optional configurations:</h5><ul><li><strong>SPDA99-201</strong> Remove PDA1 diode-array detector from system</li><li><strong>ST99-001</strong> Remove CT1 column thermostat from system</li><li><strong>SAS99-001</strong> Remove AS1 autosampler from system</li><li><strong>SUV90-001</strong> Add UV1 Variable UV/Vis detector to system</li><li><strong>SFC90-001</strong> Add FC1 Fraction collector to system</li><li><strong>SCT90-002</strong> Add CT1i column thermostat with manual injector from system</li></ul>

Products from category Liquid chromatographs focused on HPLC - page 3

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