<p><strong>At MSACL 2025, a Thermo Fisher Scientific–sponsored workshop led by Qin Fu addressed one of the most persistent challenges in proteomics: how to efficiently and reproducibly translate biomarker discoveries into clinically meaningful assays. Drawing on experience spanning academia and industry—including prior work in Jennifer Van Eyk’s lab—Fu shared practical insights into building a scalable, end-to-end biomarker discovery-to-validation pipeline.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg" alt="Thermo Fisher Scientific: Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg 245w," sizes="100vw" width="1024" height="512"></p><p>The session highlighted how emerging mass spectrometry technologies, automation, and informatics are reshaping biomarker research—reducing complexity, improving reproducibility, and accelerating the path to clinical utility.</p><h3><strong>The three tiers of biomarker assays</strong></h3><p>The workshop opened with a review of the widely accepted three-tier framework that guides biomarker development from early discovery through clinical validation:</p><h4><strong>Tier 3 – discovery</strong></h4><p>Exploratory, untargeted workflows such as data-dependent acquisition (DDA) and data-independent acquisition (DIA). These approaches prioritize breadth, enabling the identification of large-magnitude biological changes across hundreds to thousands of analytes, typically with low-to-moderate precision and without internal standards.</p><h4><strong>Tier 2 – verification</strong></h4><p>Research-grade targeted assays, including parallel reaction monitoring (PRM) and multiple reaction monitoring (MRM). These methods focus on tens to hundreds of analytes, delivering improved precision and repeatability to confirm trends observed during discovery.</p><h4><strong>Tier 1 – validation</strong></h4><p>Clinically validated assays designed to meet rigorous quality and regulatory standards. These workflows incorporate internal standards and strict quality controls to ensure quantitative reproducibility suitable for clinical and translational use.</p><p>Each tier represents a critical step toward ensuring that biomarker candidates can ultimately deliver reliable patient benefit.</p><h3><strong>The central challenge: from sample to signal</strong></h3><p>Reliable biomarker development depends on consistency across the entire analytical workflow—from biological sample preparation to mass spectrometry data acquisition and downstream analysis. Every step introduces potential sources of variability, and minimizing this analytical noise while preserving biological signal is essential.</p><p>Automation emerged as a central theme of the workshop. Beyond improving throughput, automation fundamentally enhances reproducibility. Robotic sample preparation reduces variability associated with digestion, pipetting, and handling—enabling consistent performance across hundreds or thousands of samples, a scale that is difficult to achieve manually.</p><h3><strong>Technological innovation powering a paradigm shift</strong></h3><p>Recent advances in mass spectrometry are enabling researchers to bridge the gap between discovery and validation more efficiently than ever before. The workshop highlighted several Thermo Fisher Scientific platforms driving this shift:</p><ul><li><strong>Thermo Scientific Orbitrap Astral mass spectrometer</strong><br>Optimized for discovery workflows, the Astral system delivers rapid acquisition and deep proteome coverage while maintaining high precision across large cohorts.</li><li><strong>Thermo Scientific Stellar platform</strong><br>Designed for high-throughput targeted quantification, the Stellar platform supports scalable PRM workflows. Features such as PRM Conductor enable adaptive retention time tracking, which is essential for robust performance in large studies.</li><li><strong>Thermo Scientific OptaSpray Ion Source (under evaluation)</strong><br>A hands-free ionization source designed to deliver consistent spray performance with simplified maintenance, supporting reproducibility across thousands of injections.</li></ul><p>Together, these technologies create a smoother continuum across assay tiers, shortening timelines and reducing barriers to clinical translation.</p><h3><strong>Case study: Inflammatory bowel disease (IBD) cohort</strong></h3><p>A key highlight of the presentation was a large-scale biomarker study in inflammatory bowel disease (IBD). The team conducted a 500-sample discovery analysis, followed by validation in a 1,000-sample cohort. Discovery was performed using the Orbitrap Astral system, while targeted validation employed the Stellar platform.</p><p>This integrated approach successfully confirmed established biomarkers such as C-reactive protein (CRP) while also identifying novel protein candidates with strong translational potential. Importantly, these markers demonstrated consistency across discovery and validation data sets—underscoring the power of advanced instrumentation combined with robust workflows and informatics.</p><h3><strong>From high quantity to high quality</strong></h3><p>Historically, biomarker discovery has involved a tradeoff between throughput and data quality. The workshop demonstrated that this compromise is no longer necessary. By integrating automated sample preparation, optimized informatics, and next-generation mass spectrometry, researchers can now generate high-quality, high-throughput data that is both scalable and reproducible.</p><p>This shift enables faster discovery while increasing confidence that candidate biomarkers are ready for downstream validation and clinical follow-up.</p><h3><strong>The future of biomarker translation</strong></h3><p>The workshop concluded on an optimistic note. Innovations in proteomics are fundamentally transforming biomarker development—shortening timelines, reducing costs, and accelerating the transition from discovery to clinical application.</p><p>By integrating platforms such as Orbitrap Astral, Stellar, and OptaSpray, Thermo Fisher Scientific is helping advance a new era of translational biomarker science—where precision, scalability, and reliability work together to deliver meaningful clinical impact.</p><p><i>Watch the full workshop recording to </i><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk"><i>explore the data, workflows, and results behind this end-to-end approach to biomarker discovery and validation.</i></a></p><h3><strong>Intended use disclaimer</strong></h3><p>General Laboratory Equipment – Not For Diagnostic Procedures.<br>Thermo Scientific general laboratory equipment, consumables, and software are intended for research, academic, and industrial use only. These products are not designed, validated, or approved for in vitro diagnostic or clinical use. Use of these products for diagnostic purposes may result in inaccurate results and potential health and safety risks.</p><h3><strong>Resources</strong></h3><p><strong>Workshop &amp; educational content</strong></p><ul><li>MSACL 2025 workshop recording: <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk"><i><strong>Accelerating Biomarker Discovery and Validation</strong></i></a></li><li>Other MSACL workshop recordings <i>coming soon</i></li></ul><p><strong>Thermo Fisher Scientific Product Pages</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2207"><strong>Thermo Scientific TSQ Certis Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/836"><strong>Thermo Scientific Orbitrap Astral Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1149"><strong>Thermo Scientific Stellar Mass Spectrometer</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/B51004132">Thermo Scientific OptaSpray Ion Source</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs.html">Mass spectrometer affordability programs</a> (Refurbished MS, trade-in, financing/ leasing)</li></ul><p><strong>Peer-Reviewed Literature</strong></p><ul><li>Baker ES et al. <a target="_blank" rel="noopener noreferrer" href="https://europepmc.org/article/MED/22943415"><i>Mass spectrometry for translational proteomics: progress and clinical implications.</i></a> Genome Medicine (2012).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/clinchem/article/62/1/198/5611803"><i>An Empirical Approach to Signature Peptide Choice for Selected Reaction Monitoring.</i></a> Clinical Chemistry (2016).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/mas.21750"><i>Automated proteomic sample preparation: The key component for high throughput and quantitative mass spectrometry analysis.</i></a> Mass Spectrometry Reviews (2023).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.jproteome.7b00623"><i>Highly Reproducible Automated Proteomics Sample Preparation Workflow for Quantitative Mass Spectrometry.</i></a> Journal of Proteome Research (2018).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202409446"><i>A Proteomics Pipeline for Generating Clinical Grade Biomarker Candidates from DIA-MS Discovery.</i></a> Angewandte Chemie International Edition (2024).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202507610"><i>Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort.</i></a> Angewandte Chemie International Edition (2025).</li></ul><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#Omics #BiomarkerDiscovery #MassSpectrometry #ClinicalResearch</p></blockquote>

Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility

<p><span><strong>Choosing the correct membrane for a syringe filter is an important step in achieving dependable and reproducible analytical results. Whether you work with nylon, PTFE, hydrophilic PTFE, or cellulose acetate filters, the membrane material directly influences filtration efficiency, sample integrity, and overall method performance. In this article, we explore why membrane selection matters, review the characteristics of common membrane materials, and provide practical guidance for choosing the best option for your application.</strong></span></p><h4><span><strong>Why Are Syringe Filters Important?</strong></span></h4><p><span>Syringe filters are routinely used to remove particulate matter from samples prior to analysis. Unfiltered samples can introduce contaminants into chromatographic systems, leading to clogged columns, increased system backpressure, reduced instrument lifetime, and compromised analytical performance.</span></p><p><span>Selecting an appropriate membrane is therefore essential for developing a robust and reliable HPLC workflow. An ideal membrane effectively removes particles while preserving the original composition of the sample. Since the membrane comes into direct contact with both the analyte and the sample solvent, compatibility must always be carefully considered.</span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_syringe_filters_f3eaa1381e.webp" alt="KNAUER: Syringe filters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_syringe_filters_f3eaa1381e.webp 156w," sizes="100vw" width="720" height="720"></p><p><span>Let’s examine the key factors involved in choosing the most suitable membrane.</span></p><h4><span><strong>Step 1: Consider the Nature of Your Sample</strong></span></h4><p><span>The first and most important factor is the chemical composition of the sample and the solvents involved. Different membrane materials offer different chemical resistance and sample interaction characteristics.</span></p><h5><span><strong>Nylon Membranes</strong></span></h5><p><span>Nylon is one of the most commonly used membrane materials in HPLC laboratories because of its broad compatibility with aqueous solutions and many organic solvents.</span></p><p><span><strong>Recommended applications:</strong></span></p><ul><li><span>Routine filtration of HPLC samples containing aqueous solvents, organic solvents, or mixed mobile phases.</span></li><li><span>Removal of suspended particles prior to chromatographic injection.</span></li><li><span>General-purpose laboratory filtration where versatility is required.</span></li></ul><p><span><strong>Avoid using Nylon when:</strong></span></p><ul><li><span>Working with strongly acidic solutions or samples with pH values below 3.</span></li><li><span>Filtering protein-containing samples, since proteins can adsorb to the membrane surface and reduce recovery.</span></li></ul><h5><span><strong>Cellulose Acetate (CA) Membranes</strong></span></h5><p><span>Cellulose acetate membranes exhibit very low protein binding and are widely used for biological and biochemical applications.</span></p><p><span><strong>Recommended applications:</strong></span></p><ul><li><span>Filtration of biological fluids such as serum, plasma, and cell culture media.</span></li><li><span>Applications where protein recovery must be maximized.</span></li><li><span>Aqueous laboratory procedures involving enzymes or other sensitive biomolecules.</span></li></ul><p><span><strong>Avoid using CA when:</strong></span></p><ul><li><span>Filtering samples containing organic solvents that may damage the membrane.</span></li><li><span>Working under highly acidic or highly alkaline conditions that could degrade the material.</span></li></ul><h5><span><strong>Hydrophilic PTFE (hPTFE) Membranes</strong></span></h5><p><span>Hydrophilic PTFE combines the exceptional chemical resistance of PTFE with the ability to process aqueous samples without pre-wetting.</span></p><p><span><strong>Recommended applications:</strong></span></p><ul><li><span>Filtration of both aqueous and organic solutions.</span></li><li><span>HPLC sample preparation involving mixed solvent systems.</span></li><li><span>Applications requiring compatibility across a broad pH range.</span></li></ul><p><span><strong>Avoid using hPTFE when:</strong></span></p><ul><li><span>Processing highly viscous samples that may rapidly clog the membrane.</span></li><li><span>Performing PFAS analysis, where fluorinated materials may introduce unwanted contamination.</span></li></ul><h5><span><strong>PTFE Membranes</strong></span></h5><p><span>PTFE membranes provide excellent resistance to aggressive chemicals and are especially suitable for demanding solvent environments.</span></p><p><span><strong>Recommended applications:</strong></span></p><ul><li><span>Samples containing strong acids, strong bases, or aggressive organic solvents.</span></li><li><span>Environmental, industrial, and chemical analyses involving non-polar solvents such as hexane, toluene, or acetone.</span></li><li><span>Filtration of predominantly organic solvent-based samples.</span></li></ul><p><span><strong>Avoid using PTFE when:</strong></span></p><ul><li><span>Filtering aqueous solutions without first wetting the membrane or using a hydrophilic PTFE alternative.</span></li><li><span>Working with protein-rich or highly hydrophilic samples where adsorption or poor wetting may occur.</span></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_1_4_Nylon_top_left_CA_top_right_h_PTFE_bottom_left_and_PTFE_bottom_right_86a6481d0b.jpg" alt="KNAUER: Fig. 1–4 Nylon (top left), CA (top, right), hPTFE (bottom, left), and PTFE (bottom, right)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_1_4_Nylon_top_left_CA_top_right_h_PTFE_bottom_left_and_PTFE_bottom_right_86a6481d0b.jpg 157w," sizes="100vw" width="1111" height="1107"></p><h4><span><strong>Step 2: Select an Appropriate Pore Size</strong></span></h4><p><span>The membrane pore size determines the level of particulate removal and should be selected according to the requirements of the analytical method.</span></p><p><span>Common pore sizes include:</span></p><ul><li><span><strong>0.2 µm</strong> – Suitable for removing very fine particles and for sterile filtration. Frequently used in UHPLC and LC-MS workflows.</span></li><li><span><strong>0.45 µm</strong> – The standard choice for most routine HPLC applications.</span></li><li><span><strong>1.0 µm and larger</strong> – Often used for coarse filtration or as a pre-filtration step for heavily contaminated samples.</span></li></ul><p><span>Choosing the correct pore size helps protect instrumentation while minimizing unnecessary sample loss.</span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_1_2_0_22_m_left_and_0_45_m_right_Nylon_Syringe_Filter_48ffc3d777.jpg" alt="KNAUER: Fig. 1–2 0.22 µm (left), and 0.45 µm (right) Nylon Syringe Filter" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_1_2_0_22_m_left_and_0_45_m_right_Nylon_Syringe_Filter_48ffc3d777.jpg 245w," sizes="100vw" width="1177" height="573"></p><h4><span><strong>Step 3: Verify Chemical Compatibility</strong></span></h4><p><span>Before selecting a membrane, confirm that it is compatible with both the sample matrix and the solvents present. Incompatible materials may swell, degrade, release extractables, or alter the composition of the sample.</span></p><p><span>Consulting a solvent compatibility chart is highly recommended whenever unfamiliar solvents or mixtures are involved.</span></p><h4><span><strong>Step 4: Match the Membrane to the Application</strong></span></h4><p><span>Different analytical applications often benefit from specific membrane types.</span></p><h5><span><strong>HPLC Analysis</strong></span></h5><ul><li><span>Nylon and PTFE membranes are among the most frequently used options due to their broad chemical compatibility and excellent filtration performance.</span></li></ul><h5><span><strong>Protein and Biomolecule Analysis</strong></span></h5><ul><li><span>CA, PVDF, and PES membranes are generally preferred because they exhibit low protein binding and help preserve sample recovery.</span></li></ul><h5><span><strong>Microbiological Testing</strong></span></h5><ul><li><span>Mixed cellulose ester (MCE) membranes are commonly employed for microbial monitoring and microbiological quality control procedures.</span></li></ul><p><span>Selecting a membrane tailored to the analytical objective can significantly improve data quality and method reliability.</span></p><h4><span><strong>Step 5: Evaluate Product Quality and Certification</strong></span></h4><p><span>Not all syringe filters are manufactured to the same standards. For critical applications, select products that comply with recognized quality systems and certifications such as ISO standards or CE requirements.</span></p><p><span>This becomes particularly important in regulated industries, where traceability, consistency, and documented performance are essential.</span></p><h4><span><strong>Practical Recommendations for Using Syringe Filters</strong></span></h4><p><span>Following good filtration practices can further improve analytical performance.</span></p><ul><li><span><strong>Pre-Wet Hydrophobic Membranes: </strong>Hydrophobic materials such as PTFE often require pre-wetting with a compatible organic solvent before filtering aqueous samples.</span></li><li><span><strong>Avoid Excessive Pressure: </strong>Applying excessive force may rupture the membrane or cause leakage. Luer-lock syringes are recommended to provide secure connections and controlled pressure.</span></li><li><span><strong>Use Filters Only Once: </strong>Syringe filters are intended for single-use operation. Reusing filters increases the risk of carryover and cross-contamination.</span></li><li><span><strong>Dispose of Filters Properly: </strong>Used syringe filters should be discarded according to laboratory safety procedures and local waste disposal regulations.</span></li></ul><h4><span><strong>Final Thoughts</strong></span></h4><p><span>Selecting the right syringe filter membrane is a key factor in obtaining accurate, reproducible, and reliable analytical results. By considering sample composition, solvent compatibility, pore size, and application requirements, laboratories can choose filtration solutions that protect instruments, preserve sample integrity, and improve overall analytical performance.</span></p><p><span>A carefully selected membrane may seem like a small detail, but it can have a substantial impact on the quality and robustness of your entire analytical workflow.</span></p><blockquote><p><span>If you want to optimize your HPLC workflow, check out our brand-new </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2380"><span><strong>SEPAPURE Syringe Filter</strong></span></a><span>.</span></p></blockquote>

How to Choose the Right Membrane for Your Syringe Filter

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Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry

The Xevo® G2-XS QTof combines StepWaveTM ion optics with the XS Collision Cell, providing a significant increase in sensitivity with no reduction in selectivity.

<h4><strong>eXtreme Sensitivity, eXtraordinary Selectivity, eXceptional Solutions</strong></h4><div><p><strong>For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.</strong></p><ul><li>Maximum robustness with no compromise in performance</li><li>Class-leading real-world quantitative sensitivity</li><li>Highest quality, most comprehensive qualitative information</li><li>Flexibility to adapt to changing needs</li><li>Accessible to experts and non-experts alike</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_1_b9f8dd32be/Waters-Xevo-G2-XS-QTof-Quadrupole-Time-of-Flight-Mass-Spectrometry-1.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_1_b9f8dd32be/thumbnail_Waters-Xevo-G2-XS-QTof-Quadrupole-Time-of-Flight-Mass-Spectrometry-1.jpg 173w," sizes="100vw" width="1099" height="991"></p><h3><strong>Overview</strong></h3><div><h4><strong>Maximum robustness with no compromise in performance</strong></h4><p>The trend for increasing complexity of both samples and studies can result in difficulty obtaining high quality data for every component of interest while maintaining optimum performance throughout the analysis.</p><p>The <strong>Xevo® G2-XS QTof</strong> combines <strong>StepWave<sup>TM</sup> ion optics</strong> with the <strong>XS Collision Cell</strong>, providing a significant increase in sensitivity with no reduction in selectivity.&nbsp; During long analyses, critical hardware components stay clean for longer, so results are more reproducible and the laboratory stays productive.</p><p>Meaningful information is obtained for a greater number of components across a larger population of samples than ever before, giving a more complete picture for improved understanding and more confident decision making.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_437f84bacd.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry: Maximum robustness with no compromise in performance." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_437f84bacd.jpg 224w," sizes="100vw" width="900" height="628"></p><div><h4><strong>Class-leading real-world quantitative sensitivity</strong></h4><p>In targeted quantitative analysis, the greatest challenge is to detect and quantify components of interest down to the lowest possible levels, often in the presence of interferences from complex matrix.&nbsp; Large variation in the concentrations of different components further adds to this challenge.</p><p>The <strong>Xevo G2-XS QTof</strong> combines sensitivity and selectivity with the mass accuracy, dynamic range and speed provided by <strong>QuanTofTM technology</strong> and the enhanced quantitative capability of <strong>Tof-MRM data acquisition</strong>.&nbsp; The end result is class-leading quantitative performance in real everyday laboratory conditions, demonstrated by limits of detection and quantification superior to anything achieved before with high resolution MS.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_2_d805c7aa49.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry: Class-leading real-world quantitative sensitivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_2_d805c7aa49.jpg 245w," sizes="100vw" width="900" height="312"></p><div><h4><strong>Highest quality, most comprehensive qualitative information</strong></h4><p>In addition to accurate quantitative profiles, complete understanding of a sample requires detailed and comprehensive qualitative information.</p><p><strong>MS<sup>E</sup></strong> is a simple but powerful approach that delivers accurate mass precursor and fragment ion data for every detectable component, whether chromatographically resolved or not.&nbsp; This represents the ultimate in qualitative information, and because the approach is un-targeted, the data can be interrogated again later as scientific questions evolve.</p><p><strong>FastDDA</strong> is an automated, targeted data acquisition method that provides rapid, intelligent accurate mass MS/MS capability for confirmation of known compounds or characterization of unknowns, for situations where only true MS/MS data will suffice.</p><h4><strong>Flexibility to adapt to changing needs</strong></h4><div><p>The growing emphasis on efficiency and productivity in the laboratory demands analytical systems that are not only robust and reliable, but that also have the flexibility to accomplish a wide variety of tasks today, with future-proofing for the innovations of tomorrow.&nbsp;</p><p><strong>Waters’ Universal Ion Source Architecture</strong> enables the use of a single analytical platform for many different applications and molecule types, as well as providing the option to add new functionality as requirements and priorities change.&nbsp; All source options are designed to be quickly interchangeable and ready to use within minutes, maximizing versatility and minimizing downtime.</p><div><h3><strong>Accessible to experts and non-experts alike</strong></h3><p>Traditionally the ability to achieve and maintain optimum performance from such a powerful analytical system would require a level of knowledge and experience held only by expert users.</p><p>The <strong>Xevo G2-XS QTof</strong> features <strong>IntelliStartTM technology</strong>, an intuitive user interface that automates routine tasks and ensures reproducible data of the highest quality, ensuring the full capability of the system is accessible to all.</p><p><strong>IntelliStart enables essential functions to be carried out automatically:</strong></p><ul><li>MS resolution and calibration checks</li><li>Simple setup of diverse experiments</li><li>Scheduled LC-MS system checks</li><li>Continuous system monitoring</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_3_279cf35277.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry: Accessible to experts and non-experts alike." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_3_279cf35277.jpg 136w," sizes="100vw" width="900" height="1038"></p></div></div></div></div></div></div>

Waters SELECT SERIES Cyclic IMS

The SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art, high performance, time-of-flight mass spectrometry.

<div><div id="title-c6692d35e8" data-locator="title-with-text"><h3><strong>Endless possibilities. Limitless research.</strong></h3></div></div><div><div id="text-ba9d3d94da" data-locator="text"><p><strong>Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art, high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.</strong></p><p>The SELECT SERIES Cyclic IMS enables selection of ions by both mass and mobility, a unique functionality of <strong>Cyclic Ion Mobility (cIM)</strong> that provides unparalleled flexibility and capabilities for research studies in both academia and industry. With ion mobility and mass spectrometry, you can separate by shape as well as&nbsp;<i>m/z</i>&nbsp;for separation of isomers, measure the <strong>Collisional Cross Section (CCS)</strong> of an ion, and achieve significantly cleaner mass spectral data.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_Cyclic_IMS_Novel_Cyclic_Ion_Mobility_c_IM_Technology_13abf6dd9b.jpg" alt="Waters SELECT SERIES Cyclic IMS: Novel Cyclic Ion Mobility (cIM) Technology." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_Cyclic_IMS_Novel_Cyclic_Ion_Mobility_c_IM_Technology_13abf6dd9b.jpg 234w," sizes="100vw" width="1024" height="682"></p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-26eab4b89b" data-locator="text"><ul><li>Combine <strong>cyclic ion mobility (cIM) separation</strong> with <strong>ToF mass spectrometry</strong></li><li>Separate more than ever before with ultimate ion mobility resolution for complete confidence</li><li>Perform <strong>unique IMS<sup>n</sup> experiments</strong> for increased selectivity and advanced characterization</li><li>Enable <strong>pre-mobility mass selection</strong> and <strong>mobility selection of precursor and product ions</strong></li><li>Achieve increased experimental flexibility for solving complex problems with three distinct fragmentation regions</li></ul></div></div><div><div id="text-36ff553b5f" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>For identifying and rapidly monitoring co-eluting, isomeric metabolites in chemical reactions</p><blockquote><p class="cke-user_style-important"><strong>Video: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=nauwVH0L91o"><strong>Waters SELECT SERIES Cyclic IMS</strong></a></p></blockquote><div><div id="text-8469d7776e" data-locator="text"><h3 data-locator="modal-title"><strong>Discover more with ultimate ion mobility resolution</strong></h3><p>The instrument design and control software enable a range of experiments, including acquisition of Tof data, Single pass ion mobility, and the ability to scale mobility resolution to match the complexity of a sample. Ion mobility resolution increases with the length of the mobility device and therefore with the number of passes.</p><figure class="image"><img style="aspect-ratio:1024/682;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_Cyclic_IMS_IMS_resolution_increases_with_the_number_of_passes_around_the_c_IM_device_121719dbe0.jpg" alt="Waters SELECT SERIES Cyclic IMS: IMS resolution increases with the number of passes around the cIM device. Demonstrated here by the separation of reverse sequence peptides SDGRG and GRGDS. The Arrival Time Distributions (ATDs) obtained after 100 passes around the device are inset." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_Cyclic_IMS_IMS_resolution_increases_with_the_number_of_passes_around_the_c_IM_device_121719dbe0.jpg 234w," sizes="100vw" width="1024" height="682"></figure><div><div id="text-bb2fb9f91c" data-locator="text"><h3 data-locator="modal-title"><strong>Unlock the potential in scientific discovery</strong></h3><p>The unique instrument design of the SELECT SERIES Cyclic IMS&nbsp;facilitates advanced ion mobility experiments like IMS<sup>n</sup>&nbsp;isolation. IMS<sup>n</sup>&nbsp;isolation&nbsp;extends the resolution of a specific mobility range,&nbsp;<i>e.g.,</i>&nbsp;ions of a specific species. Eject ions (without acquisition) outside of the desired mobility range, leaving the remaining species in the cIM to continue the separation process. This “trimming” approach can be undertaken numerous times and can be used, for example, to increase specificity of the selected ions or to prevent “wrap-around” in the cIM where high mobility ions catch up with low mobility ions in multi-pass experiments. Multiple cyclic sequences of different numbers of passes can be defined in one, multi-pass LC-MS method, increasing productivity by reducing the need for multiple injections of the same sample.</p></div></div><figure class="image"><img style="aspect-ratio:1024/578;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_Cyclic_IMS_Investigation_into_acyl_glucuronides_via_infusion_f3bf2c67e2.jpg" alt="Waters SELECT SERIES Cyclic IMS: Investigation into acyl glucuronides via infusion. Slicing enables further IMS separation of target metabolite (blue region) of interest and other ions can be ejected. Increasing the IMS resolution reveals an additional 4-O acyl. In collaboration with Imperial College London – Ian D. Wilson." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_Cyclic_IMS_Investigation_into_acyl_glucuronides_via_infusion_f3bf2c67e2.jpg 245w," sizes="100vw" width="1024" height="578"></figure><div><div id="text-78a4dc4d5e" data-locator="text"><h3 data-locator="modal-title"><strong>Undertake advanced structural characterization</strong></h3><p><strong>IMS<sup>n</sup>&nbsp;activation</strong>&nbsp;is ideal for <strong>advanced structural characterization</strong>. During mobility separation, excise a segment of the mobility separated species and send the ions to the pre array storage device. Unwanted ions are ejected, and the stored ions are then re-injected into the array under collision induced activation/dis-sociation conditions, as required, and subsequent mobility separation performed. The product ions can then be sent to the&nbsp;Tof<i>&nbsp;</i>for detection or can undergo further rounds of mobility selection providing the unique IMS<sup>n</sup>&nbsp;capability.</p></div></div><div><div id="text-079d02ceb8" data-locator="text"><h3 data-locator="modal-title"><strong>Imaging mass spectrometry with DESI XS and Cyclic IMS</strong></h3><p>The unique combination of&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=26&amp;mainauthorItems=5&amp;search=DESI+XS"><strong>DESI XS</strong></a><strong>&nbsp;</strong>with SELECT SERIES Cyclic IMS provides ultimate levels of specificity for <strong>MS imaging</strong> approaches. DESI XS produces a visual map of the spatial distribution of a wide range of analytes, for example small molecule drugs, metabolites, and lipids across the surface of a tissue sample, and the unique capabilities and modes of acquisition of Cyclic IMS enable comprehensive in-depth experiments to be performed.</p></div></div><div><div id="text-673d117887" data-locator="text"><h3 data-locator="modal-title"><strong>Increased sensitivity provides confidence in what you find</strong></h3><p>To complement the novel <strong>Cyclic Ion Mobility</strong> capability and for complete confidence in your data, the&nbsp;SELECT SERIES&nbsp;Cyclic IMS is equipped with the latest <strong>ToF technology</strong>. The XS transfer device maintains the fidelity of the ion mobility separation while simultaneously conditioning the ion beam for the absolute best time-of-flight performance. The new offset oa-Tof with dual gain detection system <strong>provides improved sensitivity, resolution &gt;100,000 (FWHM), reliable accurate exact mass measurements</strong> (low ppm), and <strong>improved dynamic range</strong>.</p><figure class="image"><img style="aspect-ratio:1024/682;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mass_spectrum_highlighting_resolution_of_100_000_FWHM_on_the_7_charge_state_of_monomeric_9ff8f53204.jpg" alt="Waters SELECT SERIES Cyclic IMS: Mass spectrum highlighting resolution of >100,000 (FWHM) on the 7+ charge state of monomeric." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mass_spectrum_highlighting_resolution_of_100_000_FWHM_on_the_7_charge_state_of_monomeric_9ff8f53204.jpg 234w," sizes="100vw" width="1024" height="682"></figure></div></div></div></div></div></div></div></div></div></div></div></div>

Waters SYNAPT XS High Resolution Mass Spectrometer

The SYNAPT XS Ion Mobility Time-of-Flight Mass Spectrometer provides ultimate flexibility, offering greater freedom of analytical choice to support scientific creativity and technical success for any application.

<div><div><h4><strong>Ultimate flexibility for deeper discovery</strong></h4></div></div><div><div><p><strong>In the arena of scientific discovery, the slow pace of advancement and escalating costs of research can prove to be a challenge. Unlike competitor systems with restricted inlet options, scan function limitations, or requiring multiple platforms, only Waters offers an all-encompassing high-performing LC-MS solution, the SYNAPT XS mass spectrometer, for ultimate flexibility and greater freedom of analytical choice – supporting scientific creativity and technical success for any application.</strong></p><ul><li><strong>Novel technology building blocks deliver cutting-edge analytical performance</strong></li><li><strong>SONAR</strong> and <strong>HDMSE</strong> provide a unique toolkit for interrogating complex mixtures</li><li><strong>Ion mobility</strong> multiplies peak capacity and selectivity of analysis</li><li><strong>CCS measurements</strong> increase security of compound identification</li><li><strong>Deeper discovery in Mass Spectrometry Imaging</strong> with<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/Full-Spectrum-Molecular-Imaging-/nav.htm?cid=135070661"><strong>Full Spectrum Molecular Imaging</strong></a> enabled by <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/DESI-XS---Desorption-Electrospray-Ionization-/nav.htm?cid=135047466"><strong>DESI XS</strong></a> and MALDI</li></ul><h4><strong>Overview</strong></h4><div><div><div><div><ul><li><strong>Serve the broadest range of applications </strong>with the most extensive range of chromatograph inlets for ultimate flexibility</li><li><strong>Attain fragment ion information for every detectable component</strong> for unambiguous confirmation of compound identity with DIA modes <strong>SONAR</strong>, MSE, and <strong>HDMSE</strong></li><li><strong>Generate rich fragmentation data</strong> from highly complex samples in all acquisition modes including DDA</li><li>Simplify and streamline the mass spectral imaging workflow and deliver multi-layered, information-rich data with multiple imaging techniques and accompanying High Definition Imaging (HDI) Software</li><li><strong>Achieve automated higher order structure determination </strong>thorough confident identification, intact mass analysis, and best-in-class reproducibility</li><li><strong>Enhance MS/MS possibilities</strong> using complementary fragmentation techniques with high resolution and accurate mass measurements</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>For deeper discovery by aligning complimentary workflows on a single <strong>Ion mobility</strong> enabled time-of-flight mass spectrometer with the flexibility of multiple ion sources and acquisition modes.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_4_696d77ce2b.jpg" alt="Waters SYNAPT XS High Resolution Mass Spectrometer: The Waters SYNAPT XS offers flexibility and freedom of analytical choice with an extensive range of chromatographic inlets." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_4_696d77ce2b.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div><h3><strong>Cutting edge performance with novel technology</strong></h3><p>With technology building blocks inherited from the <strong>Waters Advanced Mass Spectrometry</strong> <strong>SELECT SERIES</strong>, advanced innovation is built-in, ensuring scientists using this platform are at the cutting edge of mass spectrometry while retaining the ease of use and established end-to-end workflows for which the <strong>SYNAPT </strong>is well known.</p><ul><li><strong>StepWave&nbsp;XS -&nbsp;</strong>Redesigned segmented quadrupole transfer optics provide enhanced sensitivity for challenging compounds while further improving levels of analytical robustness.</li><li><strong>Extended ToF -&nbsp;</strong>Delivers UPLC-compatible mass resolution, matrix-tolerant dynamic range, and quantitative results for the most complex samples, while offering superior specifications to previous SYNAPT models.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_9f19abb382.jpg" alt="Waters SYNAPT XS High Resolution Mass Spectrometer: SYNAPT XS schematic." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_9f19abb382.jpg 245w," sizes="100vw" width="1024" height="546"></p></div></div><div><div><h3><strong>Interrogate complex mixtures with a unique toolkit</strong></h3><p>A complete analytical strategy requires the combination of appropriate complementary techniques to see the bigger picture. With both <strong>SONAR</strong> and IMS-based <strong>data independent acquisition</strong> (DIA) modes of operation on the SYNAPT XS, the discovery analyst is in a unique position to interrogate complex mixtures by complementary mechanisms. Both types of acquisition increase analytical <strong>peak capacity</strong>, providing ‘clean and clear’ fragmentation data, but based on different molecular properties. This provides a truly unique investigative toolbox for the in-depth interrogation of complex mixtures.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_2_9179e575a4.jpg" alt="Waters SYNAPT XS High Resolution Mass Spectrometer: During each scan the quadrupole separates co-eluting precursor masses by scanning the mass range, and transiting them in sequence. Fragment ions from different precursors can then be recorded separately and assigned with confidence." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_2_9179e575a4.jpg 245w," sizes="100vw" width="1024" height="593"></p></div></div><div><div><h3><strong>Discover more with ion mobility and CSS measurement</strong></h3><p>Conventional mass spectrometers separate components based on m/z. The SYNAPT XS also allows separation of molecules according to<strong> their size, shape, and charge during ion mobility experiments as a function of their collisional cross section</strong> (CCS). As well as ion mobility offering an additional dimension of resolution, multiplying <strong>peak capacity</strong>, and <strong>selectivity of analysis</strong> the measurement of CCS offers additional molecular identifiers. The measured CCS of an ion can be used to help confirm an ion’s identity or investigate its structure. The inclusion of ion mobility significantly increases the extent and confidence with which a scientist can profile complex mixtures and complex molecules – dramatically enhancing sample definition.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_3_2240bff527.jpg" alt="Waters SYNAPT XS High Resolution Mass Spectrometer: Retention and drift time principle ion mobility enabled data-independent LC-HDMSE analysis (LC-DIA-IM-MS)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_3_2240bff527.jpg 204w," sizes="100vw" width="1024" height="784"></p></div></div><div><div><h3><strong>Achieve ultra-confident structural characterization of components</strong></h3><p>Time aligned parallel (TAP) fragmentation is an acquisition mode unique to the T-Wave IMS design. It permits users to take the advantage of the <strong>TriWave configuration</strong>, which allows the pre-IMS T-Wave and post-IMS T-Wave to operate as two separate collision cells. The resultant CID-IMS-CID instrumental operation helps to provide ultra-confident structural characterization of components. <strong>TAP fragmentation</strong> provides a distinct advantage for building a complete structure, through superior fragment ion coverage, sensitivity, and accuracy compared to traditional MSⁿ or MS/MS techniques.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_5_4dd33f1ab5.jpg" alt="Waters SYNAPT XS High Resolution Mass Spectrometer: Schematic showing Time Aligned Parallel Fragmentation. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SYNAPT_XS_High_Resolution_Mass_Spectrometer_5_4dd33f1ab5.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div></div></div></div></div></div></div>

Waters BioAccord LC-MS System

The BioAccord LC-MS System enables routine biotherapeutic monitoring across development, manufacturing, and QC, with a compact design and user-friendly platform for non-MS experts.

<div><div id="title-61fa75209f" data-locator="title-with-text"><h3><strong>Routine biopharmaceutical analysis – accessible and accelerated</strong></h3></div></div><div><div id="text-73a19e9720" data-locator="text"><p><strong>Improving lab efficiency without sacrificing result quality is important but challenging. Now you can achieve high-quality biotherapeutic molecule data while maximizing efficiency with the ability to directly measure product attributes to assess product quality and process robustness.</strong></p><p><strong>The BioAccord LC-MS System</strong> is specifically designed for routine definition and monitoring of biotherapeutic attributes across biopharmaceutical process and product development, manufacturing, and QC, all within a small system footprint on a platform capable of operation by non-MS experts.&nbsp;</p><p>Analyze a broad range of product attributes using the intact molecule, subunits, peptide maps, and released glycans, all with greater sensitivity, selectivity, and dynamic range than traditional chromatographic and electrophoretic techniques.</p><ul><li>Make rapid, confident decisions with accessible, consistent high-quality data​</li><li>Ensure operational simplicity, result consistency, and lab productivity with workflow automation​</li><li>Compliant-ready platform that can be deployed and replicated from discovery through to QC.​</li><li>Achieve fast deployment, reliable operation, and a clear return on investment​</li></ul><h3><strong>Overview</strong></h3><ul><li>Compliant-ready platform ideal to deploy from discovery to quality control (QC)​</li><li>Achieve faster time to value, and consistent performance through automated set-up with SmartMS</li><li>Diagnose, and fix potential system issues before they affect data quality with intelligent health checks in SmartMS</li><li>Focus your team on what matters with a system that doesn't require LC-MS experts for routine operation</li><li>Make more informed, data-driven decisions with trustworthy LC-MS data directly available at the point of decision-making</li><li>Achieve the highest quality data in your lab, comparable to data previously available only from the complicated, and costly LC-MS systems used for product characterization</li></ul><p><strong>Recommended Use: </strong>For the rapid measurement of multiple product quality attributes during routine biopharmaceutical analysis.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_R_Da_Detector_1_c570b28cc2/Waters-ACQUITY-RDa-Detector-1.jpeg" alt="Waters BioAccord LC-MS System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_R_Da_Detector_1_c570b28cc2/thumbnail_Waters-ACQUITY-RDa-Detector-1.jpeg 125w," sizes="100vw" width="1024" height="1274"></p><h3><strong>Accelerate decisions with less effort to collect and process high quality data</strong></h3><p>Minimize the time spent generating data and managing LC-MS performance and maximize time for actions driven by the high quality data generated with automated set-up and guided workflows.&nbsp;</p><h4><strong>Use the streamlined workflows with the BioAccord LC-MS System for:</strong></h4><ul><li>Intact mass analysis (proteins, subunits, oligonucleotides, mRNA fragments)</li><li>Peptide mapping and multi-attribute method (MAM)</li><li>Released N-glycan analysis</li><li>Oligonucleotide sequence confirmation</li><li>Impurity analysis for proteins, peptides, and oligonucleotides</li></ul><p>These workflows streamline method set-up, data acquisition and processing, and report generation to deliver the required information with minimal manual interventions.​ In addition to these core workflows, the BioAccord System also supports a range of other applications required in biotherapeutic process and product development, like cell culture media analysis, mRNA cap, and lipid nanoparticle analysis.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Bio_Accord_LC_MS_System_Visualize_your_data_with_intuitive_and_easy_to_review_layouts_9876dbe5a8.jpg" alt="Waters BioAccord LC-MS System: Visualize your data with intuitive and easy to review layouts. These results from a peptide MAM analysis show product quality attributes that are being monitored, flagging those that are out of specification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Bio_Accord_LC_MS_System_Visualize_your_data_with_intuitive_and_easy_to_review_layouts_9876dbe5a8.jpg 245w," sizes="100vw" width="954" height="541"></p><h3><strong>Increase productivity by increasing data quality and reducing analysis failures</strong></h3><p>Non-specific adsorption of metal sensitive analytes can be unpredictable and challenging, leading to long system passivation times, large relative standard deviations (RSDs), and broad peaks that can be tough to detect and quantify.</p><p>The BioAccord LC-MS System incorporates ACQUITY Premier UPLC and Premier chemistries with MaxPeak High Performance Surfaces (HPS) Technology. These innovations maximize system readiness, decrease time to operation, and enable superior run-run and system-system consistency while improving sensitivity for the metal interacting analytes.&nbsp;</p><h4><strong>Through the application of MaxPeak HPS Technology, you can:</strong></h4><ul><li>Increase recovery and consistent detection of problematic peptides for enhanced peptide map and MAM analysis.</li><li>Achieve superior sensitivity and reproducibility for acidic glycans and lipids by minimizing analyte/surface interactions that lead to sample loss.</li><li>Save time and improve productivity by reducing or eliminating passivation for robust oligonucleotide analyses.</li><li>Minimize the risk of undetected peaks by minimizing metal-sensitive analyte loss, improving recovery and the lowering limits of detection.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Bio_Accord_LC_MS_System_The_figure_A_shows_the_extracted_ion_chromatograms_XIC_for_GFYPSDIAVEWESNGQPENNYK_PENNYK_peptide_unmodified_and_deamidated_peptides_collected_for_a_NIS_Tm_Ab_digest_b14145461f.jpg" alt="Waters BioAccord LC-MS System: The figure (A) shows the extracted ion chromatograms (XIC) for GFYPSDIAVEWESNGQPENNYK (PENNYK) peptide unmodified and deamidated peptides collected for a NISTmAb digest. The chromatographic trace in solid line shows the XIC for PENNY peptides acquired on the BioAccord System. The inset shows all modification of PENNY peptide including succinimide modification. Figure (B) shows the total normalized peak area calculated for PENNY peptides using conventional and ACQUITY Premier UPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Bio_Accord_LC_MS_System_The_figure_A_shows_the_extracted_ion_chromatograms_XIC_for_GFYPSDIAVEWESNGQPENNYK_PENNYK_peptide_unmodified_and_deamidated_peptides_collected_for_a_NIS_Tm_Ab_digest_b14145461f.jpg 245w," sizes="100vw" width="1024" height="512"></p><h3><strong>Obtain quality data, faster than ever before</strong></h3><p>Quickly getting the quality data you need for your laboratory to stay productive is paramount but deploying traditional LC-MS systems is often rather slow. The integrated nature of the BioAccord LC-MS System means the system can be deployed easily and users can be productive faster through the delivery of system and applications training with appropriate biopharmaceutical methods, sample data, and system check standards for the common biopharmaceutical analysis workflows.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Bio_Accord_LC_MS_System_Mass_accuracy_summary_for_48_injections_that_representing_six_antibodies_with_eight_replicate_injections_each_ed012d8ad7.jpg" alt="Waters BioAccord LC-MS System: Mass accuracy summary for 48 injections that representing six antibodies with eight replicate injections each. Mass accuracy summary for 48 injections that representing six antibodies with eight replicate injections each." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Bio_Accord_LC_MS_System_Mass_accuracy_summary_for_48_injections_that_representing_six_antibodies_with_eight_replicate_injections_each_ed012d8ad7.jpg 245w," sizes="100vw" width="855" height="206"></p><h4><strong>With the BioAccord LC-MS System, you can:</strong></h4><ul><li>Ensure optimal system performance with biomolecule-based installation testing.</li><li>Enable users to quickly get up to speed with outcome-based application training.</li><li>Achieve high quality data with existing personnel or respond quickly to staff and project turnover challenges with reduced training burdens.</li></ul><h3><strong>Meeting your regulatory requirements, together</strong></h3><p>Meeting corporate and regulatory expectations for compliance and data integrity is critical to your laboratory operations, and those needs don’t change because LC-MS technology is moving into roles within manufacturing and quality control (QC) organizations.</p><p>Your data quality and compliance are our priority, too. The BioAccord System is built on the compliant-ready waters_connect informatics platform and backed by the long history at Waters of delivering compliant informatics and professional qualification services to streamline deployment.</p><h4><strong>With Waters, you’ll get:</strong></h4><ul><li>A single informatics platform based on a secure relational database architecture</li><li>Full audit trail for acquisition, processing, and reporting of data</li><li>Administrator-configurable roles and permissions</li><li>Network deployment of systems for maximum data safety and controlled accessibility</li><li>Characterization (Q-Tof) and routine analysis (BioAccord) systems on a common network for efficient system, data, and information management</li><li>Professional qualification services</li></ul></div></div>

Waters SELECT SERIES MRT mass spectrometer

Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology. 

<div><div id="title-089dfa8549" data-locator="title-with-text"><h3><strong>Redefine performance with all the benefits of time-of-flight technology</strong></h3></div></div><div><div id="text-77997605f8" data-locator="text"><p><strong>Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology. The SELECT SERIES MRT provides a unique combination of ultra-high resolution and specificity independent of scan speed, resulting in unambiguous compound identification with even the most complex samples.</strong></p><p>Distinguish the fine isotope structure of small molecules, resolve nominally isobaric interferences, and baseline resolve the isotopic envelope of multiply-charged ions with high resolution MRT technology. Unlike other high-resolution mass analyzers, SELECT SERIES MRT requires no compromise to your experiments, since mass resolution is consistent over a broad mass range and scan speeds.</p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-b57ec45d49" data-locator="text"><ul><li>Confidently identify sample components with routine ppb mass accuracy&nbsp;</li><li>Resolve nominally isobaric interferences with high mass resolution, at all scan speeds</li><li>Reveal isotopic fine structure for unambiguous elemental compositions</li><li>Achieve high data quality in both MS and MS/MS</li><li>Simplify data archiving and rapidly process data with reduced data files sizes</li><li>Seamlessly interchange between MALDI, DESI XS and Electrospray sources for superior accuracy for compound identification</li></ul></div></div><div><div id="text-590eba5dee" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>For unambiguous compound identification of even the most complex samples.</p><div><div id="text-d3d9e01296" data-locator="text"><h3 data-locator="modal-title"><strong>High resolution mass spectrometry, without compromise</strong></h3><p>The SELECT SERIES MRT achieves ground-breaking Time-of-Flight (ToF) resolution with the innovative use of multiple reflections of the ion beam between two gridless electrostatic mirrors in the mass analyzer. This extends the ions’ flight&nbsp;path, spatially refocusing the ion packets through a series of periodic lenses after each reflection maintaining sensitivity.&nbsp;Resolution Enhancement Mode (REM) extends the flight path by deflecting ions back for a second pass of the MRT analyzer increasing the resolving power by &gt;50% enabling &gt;300,000 FWHM.</p><figure class="image"><img style="aspect-ratio:1272/897;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Schema_konstrukce_SELECT_SERIES_MRT_Q_Tof_systemu_a07ed0a724/Waters-Schema-konstrukce-SELECT-SERIES-MRT-QTof-systemu.jpg" alt="Waters SELECT SERIES MRT: instrument schematic." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Schema_konstrukce_SELECT_SERIES_MRT_Q_Tof_systemu_a07ed0a724/thumbnail_Waters-Schema-konstrukce-SELECT-SERIES-MRT-QTof-systemu.jpg 221w," sizes="100vw" width="1272" height="897"></figure><p>The superior performance of the SELECT SERIES MRT results in high precision and routine part-per-billion mass accuracy independent of acquisition speed, providing unsurpassed quality of mass spectrometry data and information. The instrument is operated via the SELECT SERIES&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=513164" data-di-id="di-id-e7513c98-b105e917">MassLynx</a>&nbsp;acquisition system with simple and intuitive experimental setup, acquisition, and processing of mass spectrometry data. It records data in the widely deployed Waters .raw file format, which you can easily access via the MassLynx API, export as (i)mzML, and other interchangeable data formats, ready to use in your data analysis strategy.</p><figure class="image"><img style="aspect-ratio:1024/682;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_MRT_REM_mode_fine_isotope_structure_for_caffeine_1443227594.jpg" alt="Waters SELECT SERIES MRT: REM mode fine isotope structure for caffeine." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_MRT_REM_mode_fine_isotope_structure_for_caffeine_1443227594.jpg 234w," sizes="100vw" width="1024" height="682"></figure><div><div id="text-78cca88bb7" data-locator="text"><h3 data-locator="modal-title"><strong>Redefining confidence for LC-MS</strong></h3><p>The SELECT SERIES MRT provides a new level of confidence for LC/MS experiments by routinely obtaining ppb mass accuracy, revealing fine isotope structure, all with the exceptional usability of a state-of-the-art Quadrupole Time-of-Flight (QToF). The spectacular performance enables search tolerances to be minimized, providing higher confidence in elemental composition and molecular formula assignments for known and unknown targets. Moreover, the ability to routinely access such high specificity from accurate mass for both precursor and product ions is truly transformative.</p><figure class="image"><img style="aspect-ratio:1024/570;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_MRT_Resolving_deamidations_for_confident_quantification_356c8f4783.jpg" alt="Waters SELECT SERIES MRT: Resolving deamidations for confident quantification. A) The deamidated forms of peptide HC:T23 elute in the tail of the native peptide peak. Without the ultra-high resolution of the SELECT SERIES MRT as shown in (B) identification and quantification of the deamidations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_MRT_Resolving_deamidations_for_confident_quantification_356c8f4783.jpg 245w," sizes="100vw" width="1024" height="570"></figure><div><div id="text-1092d8da82" data-locator="text"><h3 data-locator="modal-title"><strong>Redefining clarity in mass spectrometry imaging</strong></h3><p>The SELECT SERIES MRT reduces analysis times by providing crystal clear, high-resolution images, acquired at fast imaging speeds without compromising mass spectral resolution or accuracy. This enables accelerated mass spectrometry imaging experiments while still resolving analytes from interferences, revealing fine structural information. The cutting-edge technology and intuitive software combine to revolutionize mass spectrometry imaging for a wide range of applications; where the ability to map compounds that differ by only a few mDa is changing the pace of research. This includes:</p><ul><li>Tissue analysis in biomedical research</li><li>Forensic research, including fingerprint analysis</li><li>Surface analysis, ranging from surface contamination analysis for semiconductor production, to analysis of tape stripped skin samples in the cosmetics industry</li></ul><div><div id="text-7f1b1e82f7" data-locator="text"><h3 data-locator="modal-title"><strong>Maximize MS imaging capabilities with DESI and MALDI</strong></h3><p>Maximize your mass spectrometry imaging capabilities and analytical flexibility with both DESI and MALDI on the SELECT SERIES MRT. Pair the SELECT SERIES MRT with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=135047466" data-di-id="di-id-5d203d9f-b105e917">DESI XS</a>&nbsp;for high quality data and clear visualization of molecular spatial distributions. The speed and versatility of DESI imaging makes it best suited to the analysis of lipids and other small molecules under ambient, direct analysis conditions, without the need for additional matrices.</p><p>Use the high-performance MALDI source to improve imaging performance and ease-of-use, so you can rapidly image large tissue sections at high spatial resolution with improved selectivity and sensitivity. MALDI’s design uses a tightly focused laser beam profile, increasing signal-to-noise at high spatial resolutions and providing lateral resolution of 15 µm without oversampling, with data acquisition rates &gt;10 pixels per second, so scientists can acquire high intensity images quickly and efficiently. With MALDI and SELECT SERIES MRT, you can:</p><ul><li>Enable imaging of large sections with a full-sized Micro Titre Plate (MTP) format MALDI target plate</li><li>Access high spatial resolution through increased signal to noise (S/N), with a focused laser beam profile</li><li>Simplify usability with an automated isolation valve and laser focus control</li><li>Maximize productivity and uptime with easy cleaning and maintenance</li></ul><figure class="image"><img style="aspect-ratio:1349/1093;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_MRT_2_8ead9924a6/Waters-SELECT-SERIES-MRT-2.jpg" alt="Waters SELECT SERIES MRT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_MRT_2_8ead9924a6/thumbnail_Waters-SELECT-SERIES-MRT-2.jpg 193w," sizes="100vw" width="1349" height="1093"></figure></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

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