You may have the best HPLC system on the market, but to maximize your investment, you also need the best software to control the system and manage the data. If the software is complex to use, inflexible or lacking in functionality, it can greatly reduce your lab productivity, creating bottlenecks and inefficiencies. Furthermore, this can lead to unreliable results, increased error rates, cost implications and ultimately, a decrease in overall laboratory performance. By selecting the right Chromatography Data System (CDS) designed to meet current laboratory needs, you can eliminate errors and drive productivity with data that is accurate, trustworthy and secure.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Elevate_Your_HPLC_Performance_with_a_Modern_CDS_cc757246f7.jpg" alt="Thermo Fisher Scientific: Elevate Your HPLC Performance with a Modern CDS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Elevate_Your_HPLC_Performance_with_a_Modern_CDS_cc757246f7.jpg 245w," sizes="100vw" width="1024" height="512"><h3>Be flexible and be in control</h3>So, what if you have multiple HPLC’s from different vendors? <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific Chromeleon CDS</a> offers full control over the widest range of HPLC and other chromatography instruments, including those from third-party manufacturers. This ensures you can maintain flexibility, while connecting and controlling your HPLC systems effortlessly. With features, such as auto-generated instrument panels that provide fast access to commands and live analysis plots, you can simplify navigation and enhance the overall user experience, making it easier to manage and monitor instruments.<h3>Streamline your method development and validation</h3>Support for your method development and validation needs is taken care of with predefined ICH method validation templates and built-in tools for method conversion, alongside integration with specialized software for automated and intelligent HPLC method development. This integration facilitates faster and more efficient method optimization and robustness testing, while the secure centralized data storage builds the perfect platform for compliance and future data review, providing a complete solution from method development to validation.<h3>Robust compliance and secure data management</h3><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/sp_70761_cds_ensure_compliance_sp70761_en_fd2abc669a.pdf">Compliance and security</a> can be a crucial aspect of any HPLC operation, and Chromeleon CDS effectively addresses these needs. Your instrument management starts with fast integrated wizard-driven instrument qualification covering IQ, OQ and PQ with predefined templates and reports to optimize the instrument qualification process. The software employs a privilege-based approach to control access to both the instruments and the system, ensuring that only authorized and qualified personnel can interact with them. Dedicated instrument audit trails track all actions and will provide you with a full history that is searchable ensuring traceability, safeguarding the integrity of your data and operations.<h3>Keep your instruments up and running</h3>Productivity is only maintained if your HPLCs are operational and available for use. Integrated diagnostic tests offer insight into key information such as lamp operating hours or piston seal wear with warning limits for timely replacements. The active monitoring of service and qualification status allows for convenient maintenance scheduling and prevents unnecessary instrument downtime. An overview of diagnostic outcomes can also be produced as part of a routine health check ensuring that your HPLC instruments are always in optimal condition.<h3>Get more right-first-time results</h3>How can you prevent delays, time-consuming investigations, and ensure your analytical sequence runs correctly the first time? Chromeleon CDS offers you solutions to minimize user interaction, such as ready checks that automatically verify instrument configuration, methods, and sequences for issues, and automated system equilibration, which ensures the first injection is always good, eliminating the need for blank injections at the start of a sequence saving time and solvent. Automated shutdown procedures will manage a completed run, ensuring safe shutdown, system flushing, or maintaining a low flow rate to prevent component damage. Built-in system suitability tests with the ability to make in-run decisions, such as pause, stop or continue will maintain the integrity of your data and allow you to perform actions like re-injections and auto-dilutions for when samples are outside acceptable tolerance limits. Streamlining and automating the entire process of sequence creation is achieved through <a target="_blank" rel="noopener noreferrer" href="https://documents.thermofisher.com/TFS-Assets/CMD/brochures/SP-70758-CDS-Chromeleon-Streamline-Workflow-SP70758-EN.pdf">eWorkflow procedures</a>. These pre-defined templates contain all associated methods and reports, so your HPLC sequence can be automatically generated with just a few clicks, reducing errors, minimizing training, and producing reliable results faster.<h3>A software designed to optimize HPLC lab efficiency</h3>Chromeleon CDS is a no-compromise solution for your HPLC systems, designed to provide you with faster and better results through enhanced control, flexibility, diagnostics, right-first-time results, and compliance. Its user-friendly interface, comprehensive method development and validation tools, secure data management, and advanced diagnostics make it an indispensable tool for your HPLC laboratory. Find out more by downloading the case study: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cs_003880_hplc_vanquish_sanofi_optimize_manufacturing_drugs_cs003880_na_en_cf986bf4cc.pdf">Leveraging a Vanquish UHPLC system and Chromeleon CDS to optimize the manufacturing process</a> or visiting <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromatography Data System (CDS)</a>.Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#Chromeleon #ChromatographyDataSystem #HPLC #UHPLC<section><blockquote><h5>Peter Zipfell</h5>For over 25 years, he has worked extensively with analytical hardware and software transitioning from LC-MS method development through HPLC technical support to chromatography data systems. His focus has always been to support our customers by delivering software solutions across multiple industries to enable them to improve their current workflows and increase productivity.</blockquote></section>

Elevate Your HPLC Performance with a Modern CDS

<h3><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/">ISC 2026</a></h3>The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/314">International Symposium on Chromatography (ISC)</a> represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.The major focus of the symposium will be on the impact of chromatography and separation science to meet the needs of the pharmaceutical, environmental, food and health industry, as well as science and medicine. The symposium programme will reflect these themes and highlight new challenges and emerging opportunities for the science and marketing of separation and detection systems and methods.As an integral part of the scientific programme of lectures and poster sessions, an international exhibition and vendor seminars on instrumentation and services for chromatography, separation science and mass spectrometry will be organised. ISC 2026 will provide the perfect forum for attendees from academia, industry and government research institutions for scientific exchange and networking.<h3>ISC 2026 SYMPOSIUM KEY DATES</h3><h4>6-10 SEPTEMBER 2026</h4><ul><li>15 January 2026: Opening of Early-bird Registration &amp; Abstract submission</li><li>11 March 2026: Deadline for abstract submission (orals)</li><li>21 April 2026: Sending acceptance letters (orals)</li><li>15 May 2026: Deadline of early-bird registration and payment &amp; Author registration deadline (orals)</li><li>1 June 2026: Preliminary detailed program on web</li><li>1 June 2026: Deadline for abstract submission (posters)</li><li>16 June 2026: Sending acceptance letters (posters)<ul><li>Authors who submit their abstracts with a poster preference by 5 May 2026 will be notified of the outcome by 12 May 2026 and will have the opportunity to register at the early-bird rate until 15 May 2026.</li></ul></li><li>30 June 2026: Author registration deadline (posters)</li><li>30 July 2026: Deadline for abstract submission (late-breaking posters)<ul><li>without the possibility of competing for the Best Poster Award</li></ul></li><li>11 August 2026: Sending acceptance letters (late-breaking posters)</li><li>18 August 2026: Author registration deadline (late-breaking posters)</li><li>25 August 2026: Deadline for late registration &amp; payment&nbsp;</li><li>6-10 September 2026: Symposium</li></ul><h3>REGISTRATION</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal">Register HERE for the ISC 2026</a></blockquote><h3>ABSTRACT SUBMISSION</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal">Submit your Abstract HERE</a></blockquote><h3>SCIENTIFIC PROGRAM</h3><h4>SHORT COURSES</h4><h5>SC 3 Interpretation of Mass Spectra: Basic Introduction for Chromatographers</h5>🗓️ SUNDAY, 6 SEPTEMBER 2026🕗 8:30 – 11:45Mass spectrometry has become an essential tool in modern liquid chromatography, yet many chromatographers receive limited formal training in mass-spectral interpretation. This introductory short course provides a practical guide to understanding and interpreting mass spectra generated by the atmospheric-pressure ionization techniques coupled with LC: electrospray ionization (ESI), atmospheric-pressure chemical ionization (APCI), and atmospheric-pressure photoionization (APPI). The course begins by outlining the information that mass spectrometry adds beyond a chromatogram and clarifying which analytical questions mass spectrometry can – and cannot – answer. Participants receive a concise refresher on mass-spectrometric fundamentals, along with an introduction to key terminology. The principles and practical consequences of ionization methods are then discussed, with emphasis on how ionization physics, LC conditions, and mobile-phase additives shape spectral appearance. Building on this foundation, the course develops practical skills for interpreting LC-ESI spectra: locating the molecular ion, determining charge state, recognizing common adducts, distinguishing in-source artefacts, and using isotope patterns to support elemental-composition hypotheses. Participants then explore how MS/MS fragmentation provides structural clues, with straightforward rules of thumb for neutral losses and class-specific fragmentation behaviors. The course concludes with an integrative exercise that synthesizes chromatographic, full-scan, and MS/MS information to support spectral interpretation. By the end, participants will be equipped with the essential skills needed to interpret LC-MS spectra effectively and to apply mass-spectrometric reasoning in routine chromatographic analysis.&nbsp;<h4>Lecturers</h4><h5>Jan Cvačka</h5><ul><li>Josef Cvačka is head of the Mass Spectrometry Group at the Institute of <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/62">Organic Chemistry and Biochemistry of the Czech Academy of Sciences</a> and an associate professor at the Faculty of Science, Charles University in Prague. His research focuses on the structural analysis of bioactive organic compounds using advanced mass-spectrometric techniques. He develops methods for pinpointing double-bond and methyl-branching positions in lipids and aims to discover new lipid classes in biological samples. His laboratory also designs new ion sources for MS and HPLC/MS. He teaches and supervises students at Charles University and founded the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/articles?search=Czech+Museum+of+Mass+Spectrometry">Czech Museum of Mass Spectrometry</a>.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Josef_Cvacka_5cc8a0d1d4.jpg" alt="ISC 2026: Josef Cvačka" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Josef_Cvacka_5cc8a0d1d4.jpg 156w," sizes="100vw" width="510" height="510">

ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers

Eurachem and CITAC welcome analysts interested in the evaluation of chemical analysis uncertainty and in how to use this information in results interpretation. The Eurachem Week 2026 will begin with a training course on “Evaluation of the measurement uncertainty from in-house precision and recovery data” scheduled for Sunday, 10 May 2026. A two-days workshop on “Quality in Analytical Measurements: Uncertainty Evaluation and Results Interpretation” open to all interested participants will take place from 11 to 12 May 2026. On 13 May 2026, the Eurachem Working Groups will convene, followed by the Eurachem General Assembly, which will bring together the Executive and national delegates on 14 and 15 May. Both Working Group Meetings and the General Assembly are restricted to their members.The results of qualitative and quantitative chemical analyses should have an acceptable uncertainty, which should ideally be reported and considered in results interpretation.For many analytical applications, simplified uncertainty evaluations can determine uncertainty values that meet the defined requirements for this parameter. The workshop will focus on the key technical challenges involved in practical evaluations of measurement uncertainty based on precision and recovery data gathered during in-house method validation and quality control. There will be a discussion of how to model the variation of the measurement uncertainty within the analytical range and how to handle divergent recovery values from the analysis of various reference materials. A session on the use of measurement uncertainty in conformity assessment will explore how the risk of false conformity decisions can be managed.<blockquote><h5>New Eurachem guidance on using in-house precision and recovery data will be discussed at the workshop.</h5></blockquote>Topics will also include the validation and uncertainty evaluation for qualitative analyses with particular attention to current accreditation requirements for these types of analysis. The last session of the workshop will be dedicated to the evaluation of measurement uncertainty arising from sampling and using it to judge the fitness for purpose, and hence validation, of measurement procedures that include sampling. Four sessions of the workshop will include engaging breakout sessions where participants will have the chance to share their views about challenging aspects of the analytical work. Participants are invited to propose posters and oral communications on session topics or any other relevant topic for analytical chemists or stakeholders of the analytical work.<h3>Registration</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://conferences.chemistry.pt/register/eurachem2026">Register here for the workshop</a></blockquote><h4>Registration Fees</h4><h5>Early bird (EUR) - Until April 15th</h5><ul><li>Workshop: Regular participant (11 &amp; 12 May 2026): 400 EUR</li><li>Workshop: Student (11 &amp; 12 May 2026): 250 EUR</li><li>Eurachem Working Group1 (13 May 2026): 75</li><li>General Assembly2 (14 &amp; 15 May 2026): 250</li><li>Training On Uncertainty Evaluation3 (10 May 2026): 150</li></ul><h5>After April 15th</h5><ul><li>Workshop: Regular participant (11 &amp; 12 May 2026): 450 EUR</li><li>Workshop: Student (11 &amp; 12 May 2026): 300 EUR</li><li>Eurachem Working Group1 (13 May 2026): 100</li><li>General Assembly2 (14 &amp; 15 May 2026): 300</li><li>Training On Uncertainty Evaluation3 (10 May 2026): 200</li></ul><blockquote>§ - 50 EUR reduction for members of Eurachem, CITAC, SPQ, RELACRE, ForMEQ and SPMet at the workshop.10% reduction for organisations that registered more than one participant.1 - Working group members2 - Eurachem members3 - 50% reduction for workshop participants</blockquote><h3>Workshop</h3><h4>Eurachem/CITAC Workshop on Quality in Analytical Measurements:</h4><h5>Uncertainty Evaluation and Results Interpretation</h5>The results of qualitative and quantitative chemical analyses should have an acceptable uncertainty, which should ideally be reported and considered in results interpretation. For many analytical applications, simplified uncertainty evaluations can determine uncertainty values meeting defined requirements for this parameter. The workshop will focus on the key technical challenges involved in practical evaluations of measurement uncertainty based on precision and recovery data gathered during in-house method validation. It will be discussed how to model the variation of the measurement uncertainty within the analytical range and how to handle divergent recovery values from the analysis of various reference materials. A session on the use of measurement uncertainty in conformity assessment will explore how the risk of false conformity decisions can be managed.Topics will also include the validation and uncertainty evaluation of qualitative analyses with particular attention to current accreditation requirements for these types of analysis. The last session of the workshop will be dedicated to the evaluation of measurement uncertainty arising from sampling and using it to judge the fitness for purpose, and hence validation, of measurement procedures that include sampling.Four sessions of the workshop will include engaging breakout sessions where participants will have the chance to share their views about challenging aspects of the analytical work. Participants are invited to propose posters and oral communications on session topics or any other relevant topic for analytical chemists or stakeholders of the analytical work.<h3>Training Course</h3><h4>Evaluation of the measurement uncertainty from in-house precision and recovery data</h4><ul><li>10 May 2026</li></ul>A course on the fundamentals of the evaluation of the measurement uncertainty from in-house precision and recovery data will be held on Sunday, 10 May 2026. This training is targeted for analysts with a basic understanding of the measurement uncertainty concept, how uncertainty components propagate, and how the combined uncertainty is expanded. Following the morning presentation of the theory of uncertainty evaluation, the afternoon will be dedicated to applying the theory to real-world cases. Trainees should have basic skills in using Microsoft Excel spreadsheets and bring a laptop with Microsoft Excel to complete the exercises. The interaction between trainers and trainees will be promoted to guarantee learning efficiency.<h5>Trainers:</h5><ul><li>Ricardo Bettencourt da Silva, Faculdade de Ciências da Universidade de Lisboa, Portugal (rjsilva@ciencias.ulisboa.pt)</li><li>Stephen L. R. Ellison - UK National Measurement Laboratory (NML) hosted at LGC, United Kingdom</li><li>Vicki Barwick - UK National Measurement Laboratory (NML) hosted at LGC, United Kingdom</li></ul><h4>Agenda</h4><h5>8:00 Registration</h5><h5>9:00 Opening</h5><h5>9:05 Identifying, combining, and expanding uncertainty components: Theory and examples</h5><h5>9:45 Precision uncertainty: Theory and examples</h5><h5>10:30 Coffee break</h5><h5>10:50 Trueness-related uncertainty: Theory and examples</h5><h5>12:00 Additional questions and discussion</h5><h5>12:30 Lunch</h5><h5>13:30 Application example 1</h5><h5>15:30 Coffee break</h5><h5>15:50 Application example 2</h5><h5>17:00 Additional questions and discussion</h5><h5>17:30 Closing</h5><h3>Venue</h3>The series of Eurachem events will be held in:<ul><li>Meliã Lisboa Aeroporto ****</li><li>Rua C,2 1749-125 Lisboa, Portugal&nbsp;</li></ul>

Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026

Software

Article

Product

Events

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Mettler-Toledo

Phenomenex

C&EN

Waters Corporation

CHROMATOGRAPHY OF BIOSEPARATIONS 101 WEBINAR SERIES
This webinar series will cover the foundations of chromatography for the separation and analysis of peptides and proteins. Understanding the fundamentals of bioseparations will enable you to develop methods more efficiently. At the end of this series, you will be up to date on cutting edge principles and innovations surrounding bioseparations.
Who should attend? 
<ul>
<li>Those interested in a refresher on foundational principles and tips for bioseparations </li>
<li>Those revisiting which columns and mobile phases are optimal for which workflows </li>
<li>Those looking for an overview of industry advancements and new offerings</li>
</ul>
<blockquote>
Presenter: Bill Warren (Principal Product Manager – Chemistry Technology Center, Waters Corporation)
</blockquote>
<blockquote>
Bill received his Masters in Microbiology and Immunology from University of Louisville School of Medicine. In 1986, he joined Waters Corporation as a senior applications chemist involved with the research and development of HPLC, FPLC, and Capillary Electrophoresis applications for the analysis and purification of proteins, peptides, and nucleic acids. Following four years as a field based technical sales representative for Waters, Bill enjoyed a tenure as Manager, Core Product Evaluation Laboratory within the Waters Worldwide Marketing Organization. Bill currently is a Principal Bioseparation Columns Product Manager whose responsibilities involve assisting in the development and commercialization of innovative reagents and chromatography-based technologies for the separation, purification, and characterization of proteins and peptides.
</blockquote>
<blockquote>
HOST: Zerene Manaloto (Chemistry Products Marketing Manager, Waters Corporation)
</blockquote>
<blockquote>
Zerene is a Chemistry Product Marketing Manager within the Americas Field Marketing team. She holds a Chemical Engineering Bachelor’s degree from Stevens Institute of Technology. Early in her career, Zerene was a research scientist at Bristol-Myers Squibb in Process Research &amp; Development involved in preparative scale purification and glass plant operations to support IND and clinical supplies of drug candidates. Prior to joining Waters, Zerene was in consumable field sales, supporting key accounts and customers within the pharmaceutical and clinical industries.
</blockquote>

Waters Corporation: CHROMATOGRAPHY OF BIOSEPARATIONS 101 WEBINAR SERIES

FOUNDATIONS OF REVERSE PHASE SEPARATIONS FOR PEPTIDES AND PROTEINS

This webinar series will cover the foundations of chromatography for the separation and analysis of peptides and proteins.

REVERSE PHASE SEPARATIONS FOR PEPTIDES AND PROTEINS

CHROMATOGRAPHY OF BIOSEPARATIONS 101 WEBINAR SERIES
This webinar series will cover the foundations of chromatography for the separation and analysis of peptides and proteins. Understanding the fundamentals of bioseparations will enable you to develop methods more efficiently. At the end of this series, you will be up to date on cutting edge principles and innovations surrounding bioseparations.
Who should attend? 
<ul>
<li>Those interested in a refresher on foundational principles and tips for bioseparations </li>
<li>Those revisiting which columns and mobile phases are optimal for which workflows </li>
<li>Those looking for an overview of industry advancements and new offerings</li>
</ul>
<blockquote>
Presenter: Bill Warren (Principal Product Manager – Chemistry Technology Center, Waters Corporation)
</blockquote>
<blockquote>
Bill received his Masters in Microbiology and Immunology from University of Louisville School of Medicine. In 1986, he joined Waters Corporation as a senior applications chemist involved with the research and development of HPLC, FPLC, and Capillary Electrophoresis applications for the analysis and purification of proteins, peptides, and nucleic acids. Following four years as a field based technical sales representative for Waters, Bill enjoyed a tenure as Manager, Core Product Evaluation Laboratory within the Waters Worldwide Marketing Organization. Bill currently is a Principal Bioseparation Columns Product Manager whose responsibilities involve assisting in the development and commercialization of innovative reagents and chromatography-based technologies for the separation, purification, and characterization of proteins and peptides.
</blockquote>
<blockquote>
HOST: Ravali Alagandula (Chemistry Products Marketing Manager, Americas Field Marketing, Waters Corporation)
</blockquote>
<blockquote>
Ravali is a ChemistryProduct Marketing Manager within the Americas Field Marketing team at Waters. She holds a Ph. D. in Analytical Chemistry from Cleveland State University.She started her career as an LC applications scientist at Restek, developing LC-MS/MS and sample preparation methods in clinical, and life science markets. Most recently, Ravali was a Chemistry Account Manager at waters supporting key accounts and customers to promote chemistry consumable business in all market areas.
</blockquote>

ION-EXCHANGE SEPARATIONS AND BEST PRACTICES FOR SALTY SEPARATIONS

ION-EXCHANGE SEPARATIONS AND BEST PRACTICES

HILIC SEPARATIONS FOR GLYCANS AND GLYCOPEPTIDES

Key learning objectives
<ul>
<li>Reversed Phase-Ion Pair LC for Oligos - Challenges and Optimization
</li>
<li>Rapid Isolation of Oligo Therapeutics from Biological Samples
</li>
<li>High-throughput, RPC Purification
</li>
</ul>
<blockquote>
Presenter: Mahesh Thondawada (Business Development Manager Biopharma/Biologic)
</blockquote>

Analytical BioSolutions for Therapeutic Oligonucleotides

Reversed Phase-Ion Pair LC for Oligos - Challenges and Optimization...

In this presentation, we will discuss a systematic approach to LC method development, including an overview on how to ensure your LC system is performing optimally as well as the three main mechanisms that are available to adjust the selectivity of a separation:
<ul>
<li>Column chemistry</li>
<li>Organic solvent</li>
<li>Mobile phase pH</li>
</ul>
We’ll illustrate these mechanisms using a test mix of acids, bases and neutrals. We’ll also discuss the impact column hardware plays in methods development. Utilizing this knowledge, we will demonstrate this approach using a real-world example, the forced degradation of deferoxamine. 
Key Learning Objectives:
<ul>
<li>Learn how column chemistry, organic solvent and mobile phase pH influence the selectivity of chromatographic separations</li>
<li>Learn about a systematic method development approach used to develop a separation</li>
<li>Learn how to choose the “best” scouting separation for each sample and the steps taken to optimize that separation</li>
<li>Learn about the latest 2.5 µm column technologies and how they can enhance your methods and results</li>
</ul>
Who Should Attend:
-Method Development Scientists 
<ul>
<li>QA/QC Scientists </li>
<li>Laboratory Managers &amp; Directors</li>
</ul>
<blockquote>
Presenter: Kenneth Berthelette (Sr Scientist: Consumables and Lab Automation Group, Waters Corporation)
</blockquote>
<blockquote>
Presenter: Catherine Dold (Health &amp; Environment Writer, C&amp;EN Media Group)
</blockquote>

C&EN: Creating Better Chromatographic Methods Using a Systematic Approach

Creating Better Chromatographic Methods Using a Systematic Approach

We will discuss a systematic approach to LC method development, including an overview on how to ensure your LC system is performing optimally.

Creating Chromatographic Methods Using a Systematic Approach

One of the key challenges during process development and production of biologics is the timely determination of essential product attributes. Rapid feedback of product-relevant characteristics simplifies and accelerates process development and scale-up, then helps ensure product yield and quality during full-scale manufacturing.
﻿We present the use of real-time multi-angle light scattering (RT-MALS) as a process analytical technology to optimize process development of viral vectors. RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles. The application of RT-MALS in downstream processing of viral vectors is shown and discussed. 
Key Learning Objectives:
<ul>
<li>Introduction to real-time MALS (RT-MALS)</li>
<li>How RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles</li>
<li>Application of RT-MALS for viral vectors</li>
</ul>
Who Should Attend:
<ul>
<li>Bio/pharmaceutical scientists responsible for process analytical technology (PAT), downstream processing, process development and production of biologics</li>
<li>Process engineers seeking solutions for monitoring viral vectors or nanoparticle production processes</li>
</ul>
<blockquote>
Presenter: Dr. Clara Pérez Peinado (Senior Scientist, Biophysics and Process Analytics Team, Janssen Vaccines &amp; Prevention B.V)
</blockquote>
<blockquote>
Presenter: Dr. Felix Deluweit (Senior Application Scientist, Wyatt Technology Corp.)
</blockquote>
<blockquote>
Presenter: Kelly McSweeney (Contributing Editor, C&amp;EN Media Group)
</blockquote>

C&EN: Real-Time Analysis of Product Attributes in Downstream Processing of Viral Vectors

Real-Time Analysis of Product Attributes in Downstream Processing of Viral Vectors

﻿We present the use of real-time multi-angle light scattering (RT-MALS) as a process analytical technology to optimize process development of viral vectors.

RTAnalysis in Downstream Processing of Viral Vectors

The next evolution in separation science is here as you go beyond the proper engineering of an LC system, the primary concern becomes the interaction of your analytes with elements in the instrument flow path. The Waters ACQUITY Premier UPLC System features MaxPeak High Performance Surfaces (HPS) Technology, which offers improvements in separation and detection of chemically complex analytes, enabling you to minimize the risk of undetected analytes – for increased efficiency and confidence in your results.
The ACQUITY Premier system minimizes the analyte loss, improving recovery, and limits of detection. Pairing with any Waters Mass Spectrometer, the ACQUITY Premier system enables you to confidently identify and quantify unknown compounds in complex samples and confirm trace components at the lowest possible levels.
Takeaways from this webinar will be:
<ul>
<li>HPS Technology: Using Surface Science Innovations to Reduce Bias in Chromatographic separations.</li>
<li>Automate workflows from development to manufacturing.</li>
<li>Observing the Impacts of MaxPeak Premier technology in Bioseperations in Peptide analysis, Glycans, and Oligos.</li>
</ul>
Who Should Attend?
<ul>
<li>Lab managers</li>
<li>General manager</li>
<li>Manager</li>
<li>Team lead</li>
<li>Scientist</li>
<li>Analyst</li>
<li>Chemist</li>
<li>Group Leaders</li>
<li>Research associate/ assistant</li>
</ul>
<blockquote>
Presenter: Mr. Manimaran U (Asst. Product Manager- Biopharma, Waters India Pvt Ltd - Bengaluru)
</blockquote>
<blockquote>
Moderator: Ms. Daya (Executive - Marketing Support, Demand Generation, Waters India Pvt Ltd - Bengaluru)
</blockquote>

Waters Corporation: Improving Chromatographic performance to next level with Waters Premier technology

Improving Chromatographic performance to next level with Waters Premier technology

The ACQUITY Premier system minimizes the analyte loss, improving recovery, and limits of detection.

Waters Premier technology

Reversed phase column chromatography is commonplace in quality assessment of drugs. This usually involves the use of aqueous buffers, acetonitrile and/ or methanol as a mobile phase and commonly used UV detection. But what happens when excipients and drugs don&#39;t contain a chromophore? These samples can&#39;t be identified and quantified by UV detection. Our answer is Charged Aerosol Detection (CAD), which is an excellent alternative and works as a universal detector for almost all non-volatile and many semi-volatile compounds.
Please join this webinar to hear about the work of our guest speaker, Ulrike Holzgrabe, from the department of Pharmaceutical and Medicinal Chemistry at University of Wuerzburg. In her presentation, she will share her experience of using charged aerosol detection as an alternative in the quality assessment of drugs.
CAD has the flexibility and performance for analytical R&amp;D, and the simplicity and reproducibility needed for manufacturing QA/QC and can be used for the analysis of pharmaceuticals in both large and small molecules. It is a reliable and an easy-to-use solution to quantify novel compounds without the need for compound specific calibration and is a key technology in our high throughput library purification platform.
Learn how CAD can be applied in your work with tips, tricks, pointers, and expert advice. 
Join our panel of experts for a roundtable and Q&amp;A discussion 
<ul>
<li>Ulrike Holzgrabe (Institut für Pharmazie und Lebensmittelchemie University of Wuerzburg)</li>
<li>Paul Gamache (Director - Research and Development, Thermo Fisher Scientific)</li>
<li>Frank Steiner (Senior Manager- Product Applications &amp; Scientific Advisor, Thermo Fisher Scientific)</li>
<li>Tibor Muellner (Senior Product Applications Specialist, Thermo Fisher Scientific)</li>
</ul>
We invite you to submit any questions you may wish to be discussed on this registration page.
<h5>Who should attend:</h5>
<ul>
<li>Laboratory managers and directors </li>
<li>Technology leaders </li>
<li>Principal scientists </li>
<li>Laboratory analyst</li>
</ul>

Thermo Scientific: No chromophore – no HPLC analysis?

No chromophore – no HPLC analysis?

Ulrike Holzgrabe will share her experience of using charged aerosol detection as an alternative in the quality assessment of drugs.

An ongoing challenge when dealing with chromatographic separation is the presence of compounds that exhibit non-specific binding. Such compounds can exhibit poor peak shape, carryover, low sensitivity and cause an increase in back pressure and system clogging.
In high-throughput screening of compounds in drug discovery, non-specific binding can result in poor assay sensitivity and reproducibility, prolonged data analysis and complicated method development. 
In this webinar, Fiona Liddicoat and Jack Corrigan from Cyprotex, a leading ADME-Tox service provider, demonstrate how ACQUITY Premier column and system using MaxPeak High Performance Surfaces (HPS) technology can address the challenge of non-specific binding for small molecules and peptides. The benefits of this new technology include increased sensitivity, improved peak shape and reduced carryover.
This webinar focuses on:
<ul>
<li>The application of MaxPeak HPS technology for enhanced chromatographic performance of pharmaceutical compounds in UPLC-MS</li>
<li>The comparison of chromatographic performances of traditional stainless steel UPLC technology and the ACQUITY Premier solution</li>
</ul>
Key learnings:
<ul>
<li>Learn how new chromatographic technology:
<ul>
<li>significantly reduces method development turnaround</li>
<li>allows rapid diagnosis of non-specific binding</li>
<li>eliminates passivation requirement</li>
<li>applies to ADME screening</li>
</ul>
</li>
<li>Discover the benefit of ACQUITY Premier column and system in:
<ul>
<li>eliminating non-specific binding</li>
<li>improving peak shape</li>
<li>increasing sensitivity</li>
<li>reducing carryover</li>
</ul>
</li>
<li>Increase your knowledge in pharmaceutical compounds screening with UPLC-MS
</li>
</ul>
<blockquote>
Presenter: Fiona Liddicoat (Associate Principal Scientist, Cyprotex)
</blockquote>
<blockquote>
Fiona is an Associate Principal Scientist at Cyprotex leading high throughput analytical method development. Fiona graduated from University of Strathclyde with an analytical chemistry master’s degree before gaining experience in the pharmaceutical drug discovery industry. Fiona went on to join Waters as an applications chemist specialising in pharmaceutical analysis before joining Cyprotex in 2021.
</blockquote>
<blockquote>
Presenter: Jack Corrigan (Associate Scientist, Cyprotex)
</blockquote>
<blockquote>
An enthusiastic Analytical Chemist, Jack holds a first class master&#39;s degree in Chemistry. He has gained significant experience in the upkeep and use of a wide range of UPLC-MS techniques in his 2 years as an Associate Scientist at Cyprotex. As someone who understands the value of cooperation, Jack has been involved previous collaborations with Waters producing both posters and presentations showcased at various events including the DMDG early careers conference.
</blockquote>

Waters Corporation: Speeding up method development - How Cyprotex have solved the analytical challenge of non-specific binding

Speeding up method development - How Cyprotex have solved the analytical challenge of non-specific binding

How ACQUITY Premier column and system using HPS technology can address the challenge of non-specific binding for small molecules and peptides.

How Cyprotex have solved the analytical challenge

<ul>
<li>What is HPLC analysis used for, and what are the calibration standards</li>
<li>The importance of efficient data handling for HPLC analysis</li>
<li>Solutions for error-free data transfer from balance to HPLC</li>
<li>An overview of the improved HPLC workflow, including the live solution demonstration</li>
</ul>
HPLC analysis is an important technique used in most quality control or analytical laboratories. Since some critical decisions about product batches are made based on the results of these analyses, they must be correct and reliable.
To ensure accurate results are obtained at the end of the process, it is equally important to ensure that all steps in the process, including the initial weighing of samples and preparing the required concentrations, are carefully executed and that all relevant data is recorded correctly.
Any errors in weighing data or calculations or even incomplete metadata in the initial stages will be propagated downstream, leading to errors in the final result. The implications of bad decisions based on incorrect analytical results could be disastrous. 
Join our webinar with METTLER TOLEDO and Agilent Technologies experts and learn how to ensure seamless, error-free data flow from balance to analytical results.
<blockquote>
Presenter: Andrea Brütsch (Global Product Manager | METTLER TOLEDO)
</blockquote>
<blockquote>
Andrea Brütsch holds a master&#39;s degree in Chemistry and Business Studies from the University of Zurich. After various experiences at METTLER TOLEDO, Andrea wrote a paper on the trends in Laboratory Automation. Currently, he is responsible for the area of lab automation in the Laboratory Weighing department.
</blockquote>
<blockquote>
Presenter: Kevin Kölliker (Lab Informatics Application Engineer | Agilent Technologies)
</blockquote>
<blockquote>
Kevin Kölliker studied Chemistry and Business informatics and worked as a lab technician and field service engineer before joining Agilent. Combined, he has more than 10 years of experience in analytical laboratories.
</blockquote>
<blockquote>
Kevin works closely together with the lab informatics product specialists to demonstrate the power of OpenLab, and to customize the solution to meet the needs of the customers.
</blockquote>

LCMS webinars focusing on HPLC - page 37

Seamless Data Flow from Balance to HPLC